Pub Date : 2023-06-01DOI: 10.22271/27069567.2023.v5.i3b.510
Heba Elsayed Gadallah, Atef Mohamed Saad, Abdallah Ahmed Elsawy, Ahmed Fawzy Selim
{"title":"Triglyceride glucose index as a novel biomarker to identify severity of acute pancreatitis","authors":"Heba Elsayed Gadallah, Atef Mohamed Saad, Abdallah Ahmed Elsawy, Ahmed Fawzy Selim","doi":"10.22271/27069567.2023.v5.i3b.510","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3b.510","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135195507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.22271/27069567.2023.v5.i3b.509
Salma O Alshamsi, Fatema Abdulkarim, Ali Alzaidy, Hassan Ahmed, Samya Javid, Eman Ibrahim Elzain, Mohamed Awad Mahmoud Ahmed, Irum Zahid Ansari, Laila M AlDabal MD, Pramod Chhabrani
SARS-CoV-2 is a novel coronavirus that was responsible for the global COVID-19 pandemic. Our hospital was one of the largest hospitals in the UAE to admit and manage patients with this novel infection since the beginning of the pandemic in the country. The main objective of this paper was to review clinical characteristics and outcomes in adult patients with COID-19 infection admitted to our hospital.Methods: A single center retrospective observational study of 684 adult patients with confirmed COVID-19 infection admitted to a tertiary care hospital in Dubai in 2020 from 28/1/2020 until 13/05/2020. A select of clinical, radiological, epidemiological and Laboratory data was analyzed in relation to clinical presentation and disease outcome including ICU admission and overall mortality. Only patients with confirmed COVID-19 infection based on positive nasopharyngeal/throat swabs for SARS-CoV-2 virus on Real Time PCR (RT-PCR) were included in final analysis. Results: Of the total 684 adult patients, 90.9% were males (n=622) with a mean age of 44.43 years (range of 66 years, from 15 to 81 years). Significant number of patients had co-morbidities as 177 (25.9%) patients had diabetes, 121 (17.7%) had hypertension, 28 (4.1%) had heart disease and 7 (1.0%) had renal disease. The most common presenting symptoms were fever (87.4%) cough (73.5%), shortness of breath (35.1 %), URTI (18.6%), and Diarrhea (8%). The clinical conditions among these 99 patients included upper respiratory tract infection (47.5%), abnormal chest X-ray, lymphopenia, high inflammatory markers a fifth (21%) of patients had moderate pneumonia, while 7% had severe pneumonia with 22.2% requiring admission to the intensive care unit and 12.1% died. Late presentation with severe disease, an abnormal chest X-ray, lymphopenia, high inflammatory markers (C- reactive protein, ferritin and procalcitonin), and end organ damage (high creatinine or high aspartate aminotransferase) were predictors for admission to critical care unit or died.Conclusion: Older patients (age > 50 years), those with High BMI (>27), high LDH, hypertension, diabetes, SOB, High urea, presence of pneumonia, were associated significantly with a higher risk of ICU admission and higher mortality rates.
{"title":"Clinical characteristics and outcomes in adult patients with COVID-19 infection admitted to a Tertiary Care Hospital in Dubai, United Arab Emirates","authors":"Salma O Alshamsi, Fatema Abdulkarim, Ali Alzaidy, Hassan Ahmed, Samya Javid, Eman Ibrahim Elzain, Mohamed Awad Mahmoud Ahmed, Irum Zahid Ansari, Laila M AlDabal MD, Pramod Chhabrani","doi":"10.22271/27069567.2023.v5.i3b.509","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3b.509","url":null,"abstract":"SARS-CoV-2 is a novel coronavirus that was responsible for the global COVID-19 pandemic. Our hospital was one of the largest hospitals in the UAE to admit and manage patients with this novel infection since the beginning of the pandemic in the country. The main objective of this paper was to review clinical characteristics and outcomes in adult patients with COID-19 infection admitted to our hospital.Methods: A single center retrospective observational study of 684 adult patients with confirmed COVID-19 infection admitted to a tertiary care hospital in Dubai in 2020 from 28/1/2020 until 13/05/2020. A select of clinical, radiological, epidemiological and Laboratory data was analyzed in relation to clinical presentation and disease outcome including ICU admission and overall mortality. Only patients with confirmed COVID-19 infection based on positive nasopharyngeal/throat swabs for SARS-CoV-2 virus on Real Time PCR (RT-PCR) were included in final analysis. Results: Of the total 684 adult patients, 90.9% were males (n=622) with a mean age of 44.43 years (range of 66 years, from 15 to 81 years). Significant number of patients had co-morbidities as 177 (25.9%) patients had diabetes, 121 (17.7%) had hypertension, 28 (4.1%) had heart disease and 7 (1.0%) had renal disease. The most common presenting symptoms were fever (87.4%) cough (73.5%), shortness of breath (35.1 %), URTI (18.6%), and Diarrhea (8%). The clinical conditions among these 99 patients included upper respiratory tract infection (47.5%), abnormal chest X-ray, lymphopenia, high inflammatory markers a fifth (21%) of patients had moderate pneumonia, while 7% had severe pneumonia with 22.2% requiring admission to the intensive care unit and 12.1% died. Late presentation with severe disease, an abnormal chest X-ray, lymphopenia, high inflammatory markers (C- reactive protein, ferritin and procalcitonin), and end organ damage (high creatinine or high aspartate aminotransferase) were predictors for admission to critical care unit or died.Conclusion: Older patients (age > 50 years), those with High BMI (>27), high LDH, hypertension, diabetes, SOB, High urea, presence of pneumonia, were associated significantly with a higher risk of ICU admission and higher mortality rates.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135144621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.22271/27069567.2023.v5.i3b.504
Dr. Saranya RK, Dr. Rashmi Nagdeve
Background: Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for >3 months. With progressive loss of kidney function, derangements in electrolytes and acid-base inevitably occur and contribute to poor patient outcomes. The present study was undertaken to study the serum levels of calcium and electrolytes in various stages of CKD.Method: This study was conducted in 150 newly diagnosed cases of CKD admitted in Medicine ward and those visiting OPD of Tertiary Care Hospital, Shri Vasantarao Naik Government Medical College, Yavatmal during a period from 1 February 2018 to 31 October 2019. These patients fulfilled the criteria set by National Kidney Foundations’ Kidney Disease Outcome Quality Initiative for diagnosing CKD. They were studied and evaluated clinically, and laboratory investigated.Results: Most of the patients were presented in stage III (34.7%) followed by in stage V (32.7%) and stage IV (30%). As CKD deteriorates, there was worsening in renal echogenicity in ultrasonography. The serum albumin was found to be decreased and urine albumin increased as CKD progresses. In different stages of CKD, the variation in level of serum sodium was insignificant (p>0.05), while that of increase in potassium and decrease in calcium as CKD deteriorates was significant (p<0.05). Conclusion: Because of negligence and lack of awareness, most of the patients are detected in advanced stages of CKD and is associated with wide electrolyte and calcium abnormalities. Therefore, it is necessary to identify these patients in their early stages of CKD along with prompt and early recognition of derangements in electrolytes and calcium.
{"title":"A study of serum electrolytes and calcium in chronic kidney disease in rural Maharashtra","authors":"Dr. Saranya RK, Dr. Rashmi Nagdeve","doi":"10.22271/27069567.2023.v5.i3b.504","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3b.504","url":null,"abstract":"Background: Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for >3 months. With progressive loss of kidney function, derangements in electrolytes and acid-base inevitably occur and contribute to poor patient outcomes. The present study was undertaken to study the serum levels of calcium and electrolytes in various stages of CKD.Method: This study was conducted in 150 newly diagnosed cases of CKD admitted in Medicine ward and those visiting OPD of Tertiary Care Hospital, Shri Vasantarao Naik Government Medical College, Yavatmal during a period from 1 February 2018 to 31 October 2019. These patients fulfilled the criteria set by National Kidney Foundations’ Kidney Disease Outcome Quality Initiative for diagnosing CKD. They were studied and evaluated clinically, and laboratory investigated.Results: Most of the patients were presented in stage III (34.7%) followed by in stage V (32.7%) and stage IV (30%). As CKD deteriorates, there was worsening in renal echogenicity in ultrasonography. The serum albumin was found to be decreased and urine albumin increased as CKD progresses. In different stages of CKD, the variation in level of serum sodium was insignificant (p>0.05), while that of increase in potassium and decrease in calcium as CKD deteriorates was significant (p<0.05). Conclusion: Because of negligence and lack of awareness, most of the patients are detected in advanced stages of CKD and is associated with wide electrolyte and calcium abnormalities. Therefore, it is necessary to identify these patients in their early stages of CKD along with prompt and early recognition of derangements in electrolytes and calcium.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.22271/27069567.2023.v5.i3b.502
Mohamed Ali Abdelaziz Mohamed, Sherif E. Ezzat, Hala Mohammed Nagy, Nesreen Ahmed Kotb
Background: One indicator indicative of the existence of a systemic inflammatory response that may be easily and cheaply established by standard blood testing is the neutrophil-to-lymphocyte ratio (NLR). The goal of this investigation was to evaluate the usefulness of NLR in conjunction with alpha fetoprotein (AFP)or to detect hepatocellular carcinoma (HCC). Methods: This cross-sectional study involved the examination of 100 patients who were categorized into two distinct group. The first group, referred to as group A, consisted of patients who had recently been diagnosed with HCC based on positive dynamic computed tomography (CT) scans. The characteristic property of HCC during CT scans is the existence of arterial enhancement, followed by the tumor's washout in the portal-venous and/or delayed phases. The second group, referred to as group B, comprised 50 control patients who had chronic liver disease, primarily resulting from hepatitis C or hepatitis B virus (HBV) infection, as well as patients with cirrhosis and hepatitis. Results: A notable and statistically significant reduction in the levels of lymphocytes and neutrophils was seen in participants with HCC as compared to the control group. A noteworthy negative association was seen between NLR and neutrophil count, alpha-fetoprotein (AFP), alanine aminotransferase (ALT) and lymphocyte count. On the other hand, a substantial positive correlation was found aspartate aminotransferase (AST) and the NLR. The combined use of AFP and NLR has shown the ability to identify individuals with HCC with enhanced levels of sensitivity and specificity, achieving 92% and 88% respectively. Conclusions: Together, AFP and NLR were more effective than each marker alone in distinguishing between liver disease and HCC.
{"title":"Diagnostic accuracy of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma","authors":"Mohamed Ali Abdelaziz Mohamed, Sherif E. Ezzat, Hala Mohammed Nagy, Nesreen Ahmed Kotb","doi":"10.22271/27069567.2023.v5.i3b.502","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3b.502","url":null,"abstract":"Background: One indicator indicative of the existence of a systemic inflammatory response that may be easily and cheaply established by standard blood testing is the neutrophil-to-lymphocyte ratio (NLR). The goal of this investigation was to evaluate the usefulness of NLR in conjunction with alpha fetoprotein (AFP)or to detect hepatocellular carcinoma (HCC). Methods: This cross-sectional study involved the examination of 100 patients who were categorized into two distinct group. The first group, referred to as group A, consisted of patients who had recently been diagnosed with HCC based on positive dynamic computed tomography (CT) scans. The characteristic property of HCC during CT scans is the existence of arterial enhancement, followed by the tumor's washout in the portal-venous and/or delayed phases. The second group, referred to as group B, comprised 50 control patients who had chronic liver disease, primarily resulting from hepatitis C or hepatitis B virus (HBV) infection, as well as patients with cirrhosis and hepatitis. Results: A notable and statistically significant reduction in the levels of lymphocytes and neutrophils was seen in participants with HCC as compared to the control group. A noteworthy negative association was seen between NLR and neutrophil count, alpha-fetoprotein (AFP), alanine aminotransferase (ALT) and lymphocyte count. On the other hand, a substantial positive correlation was found aspartate aminotransferase (AST) and the NLR. The combined use of AFP and NLR has shown the ability to identify individuals with HCC with enhanced levels of sensitivity and specificity, achieving 92% and 88% respectively. Conclusions: Together, AFP and NLR were more effective than each marker alone in distinguishing between liver disease and HCC.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83005578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of the present study was to assess the prevalence and clinical and epidemiological factors of thyroid dysfunction (TD) in Indian patients diagnosed with metabolic syndrome (MetS). Methods: The study was conducted within the Department of General Medicine for the period of 1 year. In this study, a total of 300 patients diagnosed with Metabolic Syndrome (MetS) were included for enrollment.Results: In this study, a total of 300 patients diagnosed with Metabolic Syndrome (MetS) were included for enrollment. In both groups, there was a prevalence of female dominance over males. The mean height in the first group was 164.0±9.01, while in the second group it was 161.9±8.52. The mean weight in the groups was 79.4±13.13 and 75.8±12.29, respectively. Among the cohort of 300 patients diagnosed with Metabolic Syndrome (MetS), it was observed that 60 individuals (20%) presented with hypothyroidism, while 6 individuals (2%) exhibited overt hyperthyroidism. Conclusion: The observed prevalence of thyroid dysfunction (TD) among patients diagnosed with metabolic syndrome (MetS) was found to be significantly elevated, suggesting a potential correlation between thyroid function and MetS. The data obtained from the current study will assist in establishing a correlation between thyroid dysfunction (TD) and metabolic syndrome (MetS). The early identification of TD in individuals with MetS would be beneficial for implementing timely interventions, such as lifestyle modifications, to potentially alter the progression of the disease.
{"title":"Observational investigation of the clinico-epidemiological features of thyroid dysfunction (TD) in people with metabolic syndrome (MetS)","authors":"Harmanpreet Singh, Inderjeet Kaur, Kiratpal Singh, Ravraj Singh Dhaliwal","doi":"10.22271/27069567.2023.v5.i3b.507","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3b.507","url":null,"abstract":"Aim: The aim of the present study was to assess the prevalence and clinical and epidemiological factors of thyroid dysfunction (TD) in Indian patients diagnosed with metabolic syndrome (MetS). Methods: The study was conducted within the Department of General Medicine for the period of 1 year. In this study, a total of 300 patients diagnosed with Metabolic Syndrome (MetS) were included for enrollment.Results: In this study, a total of 300 patients diagnosed with Metabolic Syndrome (MetS) were included for enrollment. In both groups, there was a prevalence of female dominance over males. The mean height in the first group was 164.0±9.01, while in the second group it was 161.9±8.52. The mean weight in the groups was 79.4±13.13 and 75.8±12.29, respectively. Among the cohort of 300 patients diagnosed with Metabolic Syndrome (MetS), it was observed that 60 individuals (20%) presented with hypothyroidism, while 6 individuals (2%) exhibited overt hyperthyroidism. Conclusion: The observed prevalence of thyroid dysfunction (TD) among patients diagnosed with metabolic syndrome (MetS) was found to be significantly elevated, suggesting a potential correlation between thyroid function and MetS. The data obtained from the current study will assist in establishing a correlation between thyroid dysfunction (TD) and metabolic syndrome (MetS). The early identification of TD in individuals with MetS would be beneficial for implementing timely interventions, such as lifestyle modifications, to potentially alter the progression of the disease.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.22271/27069567.2023.v5.i3b.511
Sarah Medhat Abd Elaaty, Khalil Mohamed Abbas, A. M. Gawaly, L. Elahwal
{"title":"Epidemiology of renal insufficiency in inflammatory bowel disease patients in Tanta University Hospitals","authors":"Sarah Medhat Abd Elaaty, Khalil Mohamed Abbas, A. M. Gawaly, L. Elahwal","doi":"10.22271/27069567.2023.v5.i3b.511","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3b.511","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139371664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2a.475
T. P. Patel, P. Nitinkumar, Dr. Zeel Niralbhai Kodia, Madhurima Banoth, Sayantika Ghosh
Background: Type II diabetes mellitus (DM) is characterized by insulin resistance such as glucose intolerance, dyslipidemia, and hypertension, and results in an increased predisposition to atherosclerotic vascular disease. The present study was conducted to evaluate fasting and postprandial lipid profile in diabetic patients. Materials & Methods: We put 80 type II diabetes patients in group I and 80 healthy subjects in group II. Parameters such as HbA1c, FBS, PBS, total cholesterol (TC), triglycerides (TG), high density lipoprotein – cholesterol (HDL-C), very-low-density lipoprotein cholesterol (VLDL) and low-density lipoprotein cholesterol (LDL) were determined. Results: Group I had 35 males and 45 females and group II had 40 males and 40 females. The mean VLDL was 35.3 mg/dl and 29.6 mg/dl, LDL was 174.4 mg/dl and 82.2 mg/dl, TG was 180.2 mg/dl and 154.3 mg/dl, TC was 210.8 mg/dl and 172.4 mg/dl, HDL-C was 46.2 mg/dl and 56.2 mg/dl, PBS was 142.2 mg/dl and 130.4 mg/dl and HbA1c was 9.2% and 4.6% in group I and II respectively. The difference was significant ( p <0.05). Conclusion: Postprandial lipid profile had higher values as compared to fasting lipid profile among type 2 DM patients.
{"title":"Assessment of fasting and postprandial lipid profile in diabetic patients and healthy individuals","authors":"T. P. Patel, P. Nitinkumar, Dr. Zeel Niralbhai Kodia, Madhurima Banoth, Sayantika Ghosh","doi":"10.22271/27069567.2023.v5.i2a.475","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2a.475","url":null,"abstract":"Background: Type II diabetes mellitus (DM) is characterized by insulin resistance such as glucose intolerance, dyslipidemia, and hypertension, and results in an increased predisposition to atherosclerotic vascular disease. The present study was conducted to evaluate fasting and postprandial lipid profile in diabetic patients. Materials & Methods: We put 80 type II diabetes patients in group I and 80 healthy subjects in group II. Parameters such as HbA1c, FBS, PBS, total cholesterol (TC), triglycerides (TG), high density lipoprotein – cholesterol (HDL-C), very-low-density lipoprotein cholesterol (VLDL) and low-density lipoprotein cholesterol (LDL) were determined. Results: Group I had 35 males and 45 females and group II had 40 males and 40 females. The mean VLDL was 35.3 mg/dl and 29.6 mg/dl, LDL was 174.4 mg/dl and 82.2 mg/dl, TG was 180.2 mg/dl and 154.3 mg/dl, TC was 210.8 mg/dl and 172.4 mg/dl, HDL-C was 46.2 mg/dl and 56.2 mg/dl, PBS was 142.2 mg/dl and 130.4 mg/dl and HbA1c was 9.2% and 4.6% in group I and II respectively. The difference was significant ( p <0.05). Conclusion: Postprandial lipid profile had higher values as compared to fasting lipid profile among type 2 DM patients.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80163900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2a.471
Ammar Abd El Majeed Abd Ali
Background: The ABO blood types are linked to a number of serious chronic medical conditions. An link between the ABO blood group and risk for type 2 diabetes has been discovered in earlier investigations. The purpose of the research is to determine if type 2 diabetes and the ABO blood types are related in any way. Methods: A case control study that was carried out over the course of two years and eight months in the medical ward of Al-Khidhir General Hospital and a private clinic in the province of Al-Muthanna. There were 400 adults that took part, split into two groups as follows: 200 people with type 2 diabetes who were already getting treatment made up the case group, whereas 200 healthy people made up the control group. Each participant gave a blood sample, which was used for a blood group, Rh, and random blood sugar test. Results: Blood group O was shown to be the most likely to be protective against the development of type 2 DM (OR= 0.71) whereas blood group B was revealed to be a significant independent risk factor for increased chance of developing type 2 DM (OR= 2.07). As this research indicated, blood group B is associated with a high prevalence of type 2 diabetes, while blood group O has the least relationship, blood group is thought to be a risk factor and may help in disease assessment. Since people with blood group B are more prone to develop type 2 diabetes, clinicians should exercise more caution and close supervision of these patients.
{"title":"Evaluation of the relationship between ABO and Rh blood groups system with diabetes mellitus type 2 among Patients in Al-Muthanna Governorate","authors":"Ammar Abd El Majeed Abd Ali","doi":"10.22271/27069567.2023.v5.i2a.471","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2a.471","url":null,"abstract":"Background: The ABO blood types are linked to a number of serious chronic medical conditions. An link between the ABO blood group and risk for type 2 diabetes has been discovered in earlier investigations. The purpose of the research is to determine if type 2 diabetes and the ABO blood types are related in any way. Methods: A case control study that was carried out over the course of two years and eight months in the medical ward of Al-Khidhir General Hospital and a private clinic in the province of Al-Muthanna. There were 400 adults that took part, split into two groups as follows: 200 people with type 2 diabetes who were already getting treatment made up the case group, whereas 200 healthy people made up the control group. Each participant gave a blood sample, which was used for a blood group, Rh, and random blood sugar test. Results: Blood group O was shown to be the most likely to be protective against the development of type 2 DM (OR= 0.71) whereas blood group B was revealed to be a significant independent risk factor for increased chance of developing type 2 DM (OR= 2.07). As this research indicated, blood group B is associated with a high prevalence of type 2 diabetes, while blood group O has the least relationship, blood group is thought to be a risk factor and may help in disease assessment. Since people with blood group B are more prone to develop type 2 diabetes, clinicians should exercise more caution and close supervision of these patients.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73627564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2b.482
Fatma Allam Abd-Elal, Galal Eldin Moustafa Elkassas, Gamal K. Kasem, Mohamed Yousef Rabea, S. Hamam
Background: Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally. Diagnosis of hepatocellular carcinoma (HCC) should occur in an early stage, so that the patient benefits from earlier diagnosis, through treatment using established algorithms. The research aimed to evaluate the significance of Dickkopf-1 (DKK1) as a tumor biomarker for the diagnosis and prognosis of HCC in cirrhotic cases. Methods: This prospective, randomized, controlled research was carried out on 120 individuals who were classified as follow: Group I: comprised 40 cases with cirrhotic liver and HCC. Group II: comprised 30 cases with cirrhotic liver without HCC. Group III: comprised 30 cases with chronic hepatitis without cirrhosis. Control group: comprised 20 healthy individuals. Serum DKK-1 level were measured to all participants but for HCC patient group it was measured before intervention and one month after intervention (with the first CT after intervention). Results: Six cases of group I underwent microwave ablation, 13 cases underwent RFA, 20 cases underwent trans-arterial chemotherapy (TACE) and one patient underwent liver transplantation. Thirteen cases of group I were well ablated following loco regional therapy and no recurrence or de novo lesions appeared during follow up. Residual activity or de novo lesions or recurrence appeared in 26 cases who required second cession of ablation. alpha-fetoprotein (AFP) in group I was ranging between 3.6 to 2400 ng/ml with mean 698.870 ng/ml. It was higher in group I than groups II, III, and IV. DKK1 level was significantly higher in group I than groups II, III and IV, also, was significantly higher in group II than groups III and IV and it was significantly higher in group III than group IV. Conclusions: Serum DKK1 could serve as a potential diagnostic biobiomarker for HCC. DKK1 might be utilised as a predictor of therapeutic ablation outcome in cases with hepatocellular carcinoma.
{"title":"Evaluation of serum dickkopf-1 as a tumor biomarker for diagnosis and prognosis of hepatocellular carcinoma in patients with cirrhotic liver","authors":"Fatma Allam Abd-Elal, Galal Eldin Moustafa Elkassas, Gamal K. Kasem, Mohamed Yousef Rabea, S. Hamam","doi":"10.22271/27069567.2023.v5.i2b.482","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2b.482","url":null,"abstract":"Background: Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally. Diagnosis of hepatocellular carcinoma (HCC) should occur in an early stage, so that the patient benefits from earlier diagnosis, through treatment using established algorithms. The research aimed to evaluate the significance of Dickkopf-1 (DKK1) as a tumor biomarker for the diagnosis and prognosis of HCC in cirrhotic cases. Methods: This prospective, randomized, controlled research was carried out on 120 individuals who were classified as follow: Group I: comprised 40 cases with cirrhotic liver and HCC. Group II: comprised 30 cases with cirrhotic liver without HCC. Group III: comprised 30 cases with chronic hepatitis without cirrhosis. Control group: comprised 20 healthy individuals. Serum DKK-1 level were measured to all participants but for HCC patient group it was measured before intervention and one month after intervention (with the first CT after intervention). Results: Six cases of group I underwent microwave ablation, 13 cases underwent RFA, 20 cases underwent trans-arterial chemotherapy (TACE) and one patient underwent liver transplantation. Thirteen cases of group I were well ablated following loco regional therapy and no recurrence or de novo lesions appeared during follow up. Residual activity or de novo lesions or recurrence appeared in 26 cases who required second cession of ablation. alpha-fetoprotein (AFP) in group I was ranging between 3.6 to 2400 ng/ml with mean 698.870 ng/ml. It was higher in group I than groups II, III, and IV. DKK1 level was significantly higher in group I than groups II, III and IV, also, was significantly higher in group II than groups III and IV and it was significantly higher in group III than group IV. Conclusions: Serum DKK1 could serve as a potential diagnostic biobiomarker for HCC. DKK1 might be utilised as a predictor of therapeutic ablation outcome in cases with hepatocellular carcinoma.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81308231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2b.486
D. Prasad, Dr. Naresh Vishwanath Iyer Murali, Dr. Shivani Shivaprasad, Dr. Hanumesh S Kopparad
{"title":"Comparative study of serum magnesium levels in patients with type 2 diabetes mellitus with and without retinopathy at tertiary care centre in Bangalore","authors":"D. Prasad, Dr. Naresh Vishwanath Iyer Murali, Dr. Shivani Shivaprasad, Dr. Hanumesh S Kopparad","doi":"10.22271/27069567.2023.v5.i2b.486","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2b.486","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76567436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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