Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.005
Yi Peng, Yang Zhang, Ju Gao, Xiaoying Wang, Xiangzhi Fang
Objective To evaluate the application of variation of internal jugular vein respiration (VIJVR) for predicting fluid responsiveness in patients undergoing laparoscopic surgery. Methods A total of 44 patients, aged 40- 65, with body mass index (BMI) of 18-25 kg/m2, American Society of Anesthesiologists (ASA) Ⅰ or Ⅱ , were selected who received laparoscopic radical resection for rectal cancer from November 2016 to March 2017 in Northern Jiangsu People's Hospital. After patients entered into the room, their electrocardiogram (ECG), heart rate, pulse oxygen saturation (SpO2) and noninvasive blood pressure (NIBP), central vein pressure (CVP), cardiac output (CO), cardiac index (CI), stroke volume variation (SVV), and stroke volume index (SVI) were monitored. The max-imum and minimum diameters of the internal jugular vein (DIJVmax and DIJVmin) were measured by ultrasound within three respiratory cycles and VIJVR was calculated as the following formula: VIJVR=[(DIJVmax-DIJVmin)/DIJVmin] ×100%. Then, 10 min after the beginning of laparoscopy, 6% hydroxyethyl starch 130/0.4 (HES130/0.4, 500 ml) in sodium chloride injection water was infused at a dose of 7 ml/kg within 15 min. Meanwhile, heart rate, blood pressure, CO, CI, SVV, SVI and VIJVR were recorded 10 min after tracheal intubation (T1), 10 min after the beginning of pneumoperitoneum (T2) and 10 min after the end of infusion of 6% HES130/0.4 (T3). According to the increase of stroke volume index (△SVI) after volume challenge, the patients were divided into responders (group R, △SVI≥15%, n=29) and non-responders (group N, △SVI<15%, n=15). The relationship between VIJVR and fluid responsiveness was analyzed by receiver operating characteristic (ROC) curve. Results The VIJVR before volume challenge was negatively related with △SVI in the presence of pneumoperitoneum (r=-0.451, P<0.05). The area under the ROC curve (AUC) of VIJVR to predict volume responsiveness was 0.83 (95%CI 0.705-0.950, P<0.05), with a sensitivity of 65.5% and a specificity of 93.3% when the cut-off value of VIJVR was 21% for predicting volume responsiveness. Conclusions VIJVR can well predict fluid responsiveness in patients undergoing laparoscopic surgery. Key words: Variation of internal jugular vein respiration; Therapeutic laparoscopy; Fluid responsiveness
目的探讨颈内静脉呼吸变化(VIJVR)在腹腔镜手术患者液体反应性预测中的应用价值。方法选取2016年11月至2017年3月在苏北人民医院行腹腔镜直肠癌根治术的44例患者，年龄40 ~ 65岁，体重指数(BMI)为18 ~ 25 kg/m2，美国麻醉医师学会(ASA)Ⅰ或Ⅱ。患者入院后，监测心电图(ECG)、心率、脉搏血氧饱和度(SpO2)、无创血压(NIBP)、中心静脉压(CVP)、心输出量(CO)、心脏指数(CI)、脑卒中容积变化(SVV)、脑卒中容积指数(SVI)。超声测量3个呼吸周期内颈内静脉最大、最小直径(DIJVmax、DIJVmin)，计算VIJVR为:VIJVR=[(DIJVmax-DIJVmin)/DIJVmin] ×100%。然后，在腹腔镜开始后10 min，在15 min内以7 ml/kg的剂量注射氯化钠注射液中的6%羟乙基淀粉130/0.4 (HES130/0.4, 500 ml)，同时记录气管插管后10 min (T1)、气腹开始后10 min (T2)和6% HES130/0.4输注结束后10 min (T3)的心率、血压、CO、CI、SVV、SVI和VIJVR。根据脑容量刺激后脑卒中容积指数(△SVI)的增加情况将患者分为反应组(R组，△SVI≥15%，n=29)和无反应组(n组，△SVI<15%， n=15)。采用受试者工作特征(ROC)曲线分析VIJVR与流体反应性的关系。结果气腹存在时，容积冲击前VIJVR与△SVI呈负相关(r=-0.451, P<0.05)。VIJVR预测体积反应性的ROC曲线下面积(AUC)为0.83 (95%CI 0.705 ~ 0.950, P<0.05)，当VIJVR预测体积反应性的临界值为21%时，灵敏度为65.5%，特异性为93.3%。结论VIJVR能较好地预测腹腔镜手术患者的液体反应性。关键词:颈内静脉呼吸变化;腹腔镜治疗;流体的响应能力
{"title":"Application of variation of internal jugular vein respiration for predicting fluid responsiveness in patients undergoing laparo- scopic surgery","authors":"Yi Peng, Yang Zhang, Ju Gao, Xiaoying Wang, Xiangzhi Fang","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.005","url":null,"abstract":"Objective \u0000To evaluate the application of variation of internal jugular vein respiration (VIJVR) for predicting fluid responsiveness in patients undergoing laparoscopic surgery. \u0000 \u0000 \u0000Methods \u0000A total of 44 patients, aged 40- 65, with body mass index (BMI) of 18-25 kg/m2, American Society of Anesthesiologists (ASA) Ⅰ or Ⅱ , were selected who received laparoscopic radical resection for rectal cancer from November 2016 to March 2017 in Northern Jiangsu People's Hospital. After patients entered into the room, their electrocardiogram (ECG), heart rate, pulse oxygen saturation (SpO2) and noninvasive blood pressure (NIBP), central vein pressure (CVP), cardiac output (CO), cardiac index (CI), stroke volume variation (SVV), and stroke volume index (SVI) were monitored. The max-imum and minimum diameters of the internal jugular vein (DIJVmax and DIJVmin) were measured by ultrasound within three respiratory cycles and VIJVR was calculated as the following formula: VIJVR=[(DIJVmax-DIJVmin)/DIJVmin] ×100%. Then, 10 min after the beginning of laparoscopy, 6% hydroxyethyl starch 130/0.4 (HES130/0.4, 500 ml) in sodium chloride injection water was infused at a dose of 7 ml/kg within 15 min. Meanwhile, heart rate, blood pressure, CO, CI, SVV, SVI and VIJVR were recorded 10 min after tracheal intubation (T1), 10 min after the beginning of pneumoperitoneum (T2) and 10 min after the end of infusion of 6% HES130/0.4 (T3). According to the increase of stroke volume index (△SVI) after volume challenge, the patients were divided into responders (group R, △SVI≥15%, n=29) and non-responders (group N, △SVI<15%, n=15). The relationship between VIJVR and fluid responsiveness was analyzed by receiver operating characteristic (ROC) curve. \u0000 \u0000 \u0000Results \u0000The VIJVR before volume challenge was negatively related with △SVI in the presence of pneumoperitoneum (r=-0.451, P<0.05). The area under the ROC curve (AUC) of VIJVR to predict volume responsiveness was 0.83 (95%CI 0.705-0.950, P<0.05), with a sensitivity of 65.5% and a specificity of 93.3% when the cut-off value of VIJVR was 21% for predicting volume responsiveness. \u0000 \u0000 \u0000Conclusions \u0000VIJVR can well predict fluid responsiveness in patients undergoing laparoscopic surgery. \u0000 \u0000 \u0000Key words: \u0000Variation of internal jugular vein respiration; Therapeutic laparoscopy; Fluid responsiveness","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42885807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TREK-1, a member of two-pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK-1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK-1, this review concisely outlines the structure, function, distribution and modulation of TREK-1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK-1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs. Key words: TREK-1; Tow-pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression
{"title":"The involvement of two-pore domain K+ channel TREK-1 in anesthesia","authors":"Shuai Zhao, Yeling Ouyang, Zhiqiang Hu, Xiangdong Chen","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.023","url":null,"abstract":"TREK-1, a member of two-pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK-1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK-1, this review concisely outlines the structure, function, distribution and modulation of TREK-1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK-1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs. \u0000 \u0000 \u0000Key words: \u0000TREK-1; Tow-pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"105-110"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43858442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.014
Pengpeng Guo, Jun Wang
Nalbuphine hydrochloride is an agonist-antagonist opioid that has analgesic and sedative effects, which can be used in perioperative period of pediatric patient. Nalbuphine hydrochloride reverses the adverse effects of μ receptor agonist (e.g. nausea, vomiting, itching) without influencing its analgesic effects. Due to the ceiling effect, nalbuphine does not cause respiratory depression. Nalbuphine has a higher safety factor, which makes it one of the most commonly used analgesic in paediatric patients. The application of nalbuphine is more popular in the country, thus, the indications of using nalbuphine in pediatric anesthesia should be clearly defined. The pharmacological properties of nalbuphine, clinical application of pediatric anesthesia were summarized in this review. Key words: Nalbuphine; Pediatric anesthesia; Analgesia; Sedation; Application
{"title":"Characteristics of nalbuphine and its application in pediatric anesthesia","authors":"Pengpeng Guo, Jun Wang","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.014","url":null,"abstract":"Nalbuphine hydrochloride is an agonist-antagonist opioid that has analgesic and sedative effects, which can be used in perioperative period of pediatric patient. Nalbuphine hydrochloride reverses the adverse effects of μ receptor agonist (e.g. nausea, vomiting, itching) without influencing its analgesic effects. Due to the ceiling effect, nalbuphine does not cause respiratory depression. Nalbuphine has a higher safety factor, which makes it one of the most commonly used analgesic in paediatric patients. The application of nalbuphine is more popular in the country, thus, the indications of using nalbuphine in pediatric anesthesia should be clearly defined. The pharmacological properties of nalbuphine, clinical application of pediatric anesthesia were summarized in this review. \u0000 \u0000 \u0000Key words: \u0000Nalbuphine; Pediatric anesthesia; Analgesia; Sedation; Application","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49231835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.020
Zhenkai Xu
Chronic pain is a complicated disease and its pathological mechanism remains unclear, with poor clinical efficacy. An increasing number of evidence indicates that epigenetic regulation is involved in the development of chronic pain. Histone methylation, an important form of epigenetic modification, also plays a pivotal role in chronic pain. This review is designed to summarize the relationship between histone methylation and chronic pain. The biological effects of histone methylation are also discussed. The effects of histone methylation in chronic pain are further discussed, so as to lay foundation for the development of more effective chronic pain-targeted drugs. Key words: Histone methylation; Epigenetic; Chronic pain
{"title":"Recent progress in the relationship between histone methylation and chronic pain","authors":"Zhenkai Xu","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.020","url":null,"abstract":"Chronic pain is a complicated disease and its pathological mechanism remains unclear, with poor clinical efficacy. An increasing number of evidence indicates that epigenetic regulation is involved in the development of chronic pain. Histone methylation, an important form of epigenetic modification, also plays a pivotal role in chronic pain. This review is designed to summarize the relationship between histone methylation and chronic pain. The biological effects of histone methylation are also discussed. The effects of histone methylation in chronic pain are further discussed, so as to lay foundation for the development of more effective chronic pain-targeted drugs. \u0000 \u0000 \u0000Key words: \u0000Histone methylation; Epigenetic; Chronic pain","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47105864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.001
Bai-song Zhao, Yongying Pan
Objective To investigate the effect of kindlin-1 on astrocyte activation in the spinal cord of rats with neuropathic pain. Methods A total of 18 male 10-12-week-old SD rats, weight 250-280 g, were divided into three groups according to the random number table method (n=6): a sham operation group (group S), a neuropathic pain group (group NP) and a kindlin-1 inhibition group (group K). A neuropathic pain model was established by chronic constriction of the sciatic nerve. The sciatic nerve of group S was only being exposed without ligation. Rats in group K were intrathecally injected with short hairpin RNA (shRNA) 21 d before surgery to inhibit the expression of kindlin-1. Those in groups S and NP were intrathecally injected with viral vector 21 d before surgery for control. The paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured 1 d before surgery and 1, 4, 7, 10 d and 13 d after surgery, respectively. When pain threshold measurement finished 13 d after surgery, the rats were sacrificed to collect the spinal cord tissue. The expression of kindlin-1 and astrocytes were detected by immunofluorescent double staining. Also, the expression of kindlin-1 in the spinal cord was measured by Western blot. Results Compared with group S, rats in group NP had reduced PWMT and shortened PWTL as well as up-regulated expression of kindlin-1 protein in the spinal cord 4, 7, 10 d and 13 d after surgery. Meanwhile, increases in optical density (D) value of kindlin-1 and astrocyte activation rate were also seen in group NP (P<0.05). Compared with group NP, group K had increased PWMT and extended PWTL as well as down-regulated expression of kindlin-1 in the spinal cord 4, 7, 10 d and 13 d after surgery. Meanwhile, decreases in D value of kindlin-1 and astrocyte activation rate were seen in group K (P<0.05). Conclusions Kindlin-1 is involved in the activation of astrocytes in the spinal cord of rats with neuropathic pain. Key words: Kindlin-1; Neuropathic pain; Astrocyte; Spinal cord
{"title":"Influence of kindlin-1 on astrocyte activation in the spinal cord of rats with neuropathic pain","authors":"Bai-song Zhao, Yongying Pan","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.001","url":null,"abstract":"Objective \u0000To investigate the effect of kindlin-1 on astrocyte activation in the spinal cord of rats with neuropathic pain. \u0000 \u0000 \u0000Methods \u0000A total of 18 male 10-12-week-old SD rats, weight 250-280 g, were divided into three groups according to the random number table method (n=6): a sham operation group (group S), a neuropathic pain group (group NP) and a kindlin-1 inhibition group (group K). A neuropathic pain model was established by chronic constriction of the sciatic nerve. The sciatic nerve of group S was only being exposed without ligation. Rats in group K were intrathecally injected with short hairpin RNA (shRNA) 21 d before surgery to inhibit the expression of kindlin-1. Those in groups S and NP were intrathecally injected with viral vector 21 d before surgery for control. The paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured 1 d before surgery and 1, 4, 7, 10 d and 13 d after surgery, respectively. When pain threshold measurement finished 13 d after surgery, the rats were sacrificed to collect the spinal cord tissue. The expression of kindlin-1 and astrocytes were detected by immunofluorescent double staining. Also, the expression of kindlin-1 in the spinal cord was measured by Western blot. \u0000 \u0000 \u0000Results \u0000Compared with group S, rats in group NP had reduced PWMT and shortened PWTL as well as up-regulated expression of kindlin-1 protein in the spinal cord 4, 7, 10 d and 13 d after surgery. Meanwhile, increases in optical density (D) value of kindlin-1 and astrocyte activation rate were also seen in group NP (P<0.05). Compared with group NP, group K had increased PWMT and extended PWTL as well as down-regulated expression of kindlin-1 in the spinal cord 4, 7, 10 d and 13 d after surgery. Meanwhile, decreases in D value of kindlin-1 and astrocyte activation rate were seen in group K (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Kindlin-1 is involved in the activation of astrocytes in the spinal cord of rats with neuropathic pain. \u0000 \u0000 \u0000Key words: \u0000Kindlin-1; Neuropathic pain; Astrocyte; Spinal cord","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42464446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.012
X. Hu, Haiyan Huo, S. Meng, Lin-zhong Zhang
Objective To investigate the changes of dynorphin A (DYN-A) in plasma and derived from peripheral white blood cells (WBCs) of diabetic patients during the perioperative period. Methods Patients scheduled for posterior lumbar interbody fusion (PLIF) under general anesthesia were selected and divided into two groups: a non-diabetes group (an NDM group, n=49) and a diabetes group (a DM group, n=23). The total number of peripheral WBCs and their classification such as lymphocytes, monocytes, and granulocytes were counted before and after operation. Before anesthesia (T1), and after awakening from anesthesia (T2), blood samples from the non-infusion sided elbow vein were collected. The plasma levels of DYN-A were measured by enzyme-linked immunosorbent assay(ELISA). Flow cytometry (FCM) was used to determine the percentage of DYN-A fluorescence positive cells and mean fluorescence intensity (MFI) of WBCs. Results In the NDM group, the total number of peripheral WBCs at T2 [(12.9±4.1)×109/L] was remarkably higher than the count at T1 [(6.3±1.6)×109/L](P 0.05). Conclusions The total number of peripheral WBCs significantly increases in the diabetic patients during the perioperative period, with the most obvious increase in granulocyte count. The percentage of DYN-A positive cells in leukocyte classification significantly decreases, while the level of DYN-A in plasma and derived from granulocytes also decreases. These changes are related to the perioperative stress and immune status of the diabetic patients. Key words: Diabetes; Perioperative period; White blood cell; Dynorphin
{"title":"The changes of dynorphin in the peripheral white blood cells and plasma of diabetic patients during the perioperative period","authors":"X. Hu, Haiyan Huo, S. Meng, Lin-zhong Zhang","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.012","url":null,"abstract":"Objective \u0000To investigate the changes of dynorphin A (DYN-A) in plasma and derived from peripheral white blood cells (WBCs) of diabetic patients during the perioperative period. \u0000 \u0000 \u0000Methods \u0000Patients scheduled for posterior lumbar interbody fusion (PLIF) under general anesthesia were selected and divided into two groups: a non-diabetes group (an NDM group, n=49) and a diabetes group (a DM group, n=23). The total number of peripheral WBCs and their classification such as lymphocytes, monocytes, and granulocytes were counted before and after operation. Before anesthesia (T1), and after awakening from anesthesia (T2), blood samples from the non-infusion sided elbow vein were collected. The plasma levels of DYN-A were measured by enzyme-linked immunosorbent assay(ELISA). Flow cytometry (FCM) was used to determine the percentage of DYN-A fluorescence positive cells and mean fluorescence intensity (MFI) of WBCs. \u0000 \u0000 \u0000Results \u0000In the NDM group, the total number of peripheral WBCs at T2 [(12.9±4.1)×109/L] was remarkably higher than the count at T1 [(6.3±1.6)×109/L](P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The total number of peripheral WBCs significantly increases in the diabetic patients during the perioperative period, with the most obvious increase in granulocyte count. The percentage of DYN-A positive cells in leukocyte classification significantly decreases, while the level of DYN-A in plasma and derived from granulocytes also decreases. These changes are related to the perioperative stress and immune status of the diabetic patients. \u0000 \u0000 \u0000Key words: \u0000Diabetes; Perioperative period; White blood cell; Dynorphin","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45614545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.026
Qingqing Han
With the development of technology of surgery and human life span increasing, more and more elderly patients have the opportunities to underwent surgery. Therefore, the complications of such kinds of patients get more attention. Postoperative Delirium (POD) is a common postoperative complication especially in elderly patients. This review summarized genetic risk factors,physiological and immunological changes associated with POD, with a focus on the biomarkers of POD in recent studies. This review introduces the delirium biomarkers of the cholinergic neurons in nerve system, inflammatory response, neurotransmitters, brain injury markers, neurotrophic factors and so on. We try to establish the predictive model of delirium so that providing theoretical basis for promoting diagnosis and treatment of POD. Key words: Postoperative delirium; Biomarkers; Mechanism
{"title":"Review advances of postoperative delirium biomarkers","authors":"Qingqing Han","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.026","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.026","url":null,"abstract":"With the development of technology of surgery and human life span increasing, more and more elderly patients have the opportunities to underwent surgery. Therefore, the complications of such kinds of patients get more attention. Postoperative Delirium (POD) is a common postoperative complication especially in elderly patients. This review summarized genetic risk factors,physiological and immunological changes associated with POD, with a focus on the biomarkers of POD in recent studies. This review introduces the delirium biomarkers of the cholinergic neurons in nerve system, inflammatory response, neurotransmitters, brain injury markers, neurotrophic factors and so on. We try to establish the predictive model of delirium so that providing theoretical basis for promoting diagnosis and treatment of POD. \u0000 \u0000 \u0000Key words: \u0000Postoperative delirium; Biomarkers; Mechanism","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"121-124"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47059415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.008
Chun Xu, Chengmi Zhang
Objective To explore the effects of different internal diameters of endotracheal tubes on the pulmonary ventilation function of children with snoring disease during surgery. Methods One hundred children with snoring disease scheduled for adenoidectomy and tonsillectomy under general anesthesia with tracheal intubation were selected and divided into three groups,according to a random number table: a small diameter group [internal diameter (ID)=(ages/4+3.5) mm, group S, n=33], an appropriate group [ID= (ages/4+4.0) mm, group A, n=28], and a large diameter group [ID=(ages/4+4.5) mm, group L, n=29]. After mechanical ventilation under general anesthesia, the following respiratory parameters in the three groups were monitored during surgery: peak airway pressure (Ppeak), plateau airway pressure (Pplat), pulmonary compliance (C), forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) ratio (FEV1%). Results Ppeak, and Pplat in group S were (16.8±2.8) cmH2O (1 cmH2O=0.098 kPa) and (13.6±3.1) cmH2O, respectively, which were significantly higher than those in groups A and L (P<0.05). Ppeak, and Pplat were not significantly changed between groups A and L. FEV1% in group S was (77±5) % which was significantly lower than that in groups A [(80±3)%] and L [(82±5)%] (P<0.05). FEV1% was not significantly changed between groups A and L. Compliance was not significantly different among these groups. Conclusions Small endotracheal tubes can increase Ppeak and Pplat, and reduce FEV1%, with negative effects on pulmonary ventilation function for children with snoring disease during surgery. Key words: Tonsillectomy and adenoidectomy; Endotracheal intubation; Endotracheal tube; Respiratory function; Children
{"title":"Effects of different internal diameters of endotracheal tubes on the pulmonary ventilation function of children with snoring disease during surgery","authors":"Chun Xu, Chengmi Zhang","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.008","url":null,"abstract":"Objective \u0000To explore the effects of different internal diameters of endotracheal tubes on the pulmonary ventilation function of children with snoring disease during surgery. \u0000 \u0000 \u0000Methods \u0000One hundred children with snoring disease scheduled for adenoidectomy and tonsillectomy under general anesthesia with tracheal intubation were selected and divided into three groups,according to a random number table: a small diameter group [internal diameter (ID)=(ages/4+3.5) mm, group S, n=33], an appropriate group [ID= (ages/4+4.0) mm, group A, n=28], and a large diameter group [ID=(ages/4+4.5) mm, group L, n=29]. After mechanical ventilation under general anesthesia, the following respiratory parameters in the three groups were monitored during surgery: peak airway pressure (Ppeak), plateau airway pressure (Pplat), pulmonary compliance (C), forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) ratio (FEV1%). \u0000 \u0000 \u0000Results \u0000Ppeak, and Pplat in group S were (16.8±2.8) cmH2O (1 cmH2O=0.098 kPa) and (13.6±3.1) cmH2O, respectively, which were significantly higher than those in groups A and L (P<0.05). Ppeak, and Pplat were not significantly changed between groups A and L. FEV1% in group S was (77±5) % which was significantly lower than that in groups A [(80±3)%] and L [(82±5)%] (P<0.05). FEV1% was not significantly changed between groups A and L. Compliance was not significantly different among these groups. \u0000 \u0000 \u0000Conclusions \u0000Small endotracheal tubes can increase Ppeak and Pplat, and reduce FEV1%, with negative effects on pulmonary ventilation function for children with snoring disease during surgery. \u0000 \u0000 \u0000Key words: \u0000Tonsillectomy and adenoidectomy; Endotracheal intubation; Endotracheal tube; Respiratory function; Children","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"35-38"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44254888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.018
D. Tang, Xiaomei Xue
Hypercapnia respiratory failure is one of the common types of respiratory failure in clinical practice. Traditional oxygen therapy can improve oxygenation, but may inevitable cause some complications. In recent years, high-flow nasal humidified oxygen (HFNC) therapy has been widely used in clinical setting as a new effective method. It uses high speed of oxygen flow to reduce the anatomical dead space of the mouth, nose and pharynx, reduce CO2 re-inspiration, produce positive pressure at the end of exhalation, increase expiratory lung volume and become the ideal choice of patients with high carbonate type of respiratory failure. This paper reviews the application of HFNC therapy in hypercapnic respiratory failure in recent years. Key words: High-flow nasal humidified oxygen therapy; Respiratory failure; Hypercapnia
{"title":"Application of high-flow nasal humidified oxygen therapy in patients with hypercapnic respiratory failure","authors":"D. Tang, Xiaomei Xue","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.018","url":null,"abstract":"Hypercapnia respiratory failure is one of the common types of respiratory failure in clinical practice. Traditional oxygen therapy can improve oxygenation, but may inevitable cause some complications. In recent years, high-flow nasal humidified oxygen (HFNC) therapy has been widely used in clinical setting as a new effective method. It uses high speed of oxygen flow to reduce the anatomical dead space of the mouth, nose and pharynx, reduce CO2 re-inspiration, produce positive pressure at the end of exhalation, increase expiratory lung volume and become the ideal choice of patients with high carbonate type of respiratory failure. This paper reviews the application of HFNC therapy in hypercapnic respiratory failure in recent years. \u0000 \u0000 \u0000Key words: \u0000High-flow nasal humidified oxygen therapy; Respiratory failure; Hypercapnia","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43670303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.006
Qiaoheng Wang, D. Huai, Weibing Zhao, Xuefang Zhu, Xiaojun Ding, Jun Wang, Chenglan Xie
Objective To investigate the effect of perioperative intravenous lidocaine infusion on postoperative early recovery quality in patients undergoing upper airway surgery. Methods One hundred and twenty patients undergoing upper airway surgery were divided into two groups according to a random number table: a lidocaine group (group L) and a control group (group C), with 60 patients in each group. Group L was administered with 2.0 mg/kg lidocaine over 10 min before induction of anesthesia, followed by intravenous infusion at 2 mg·kg-1· h-1 until the end of surgery. Group C was given the same volume of normal saline. The 40-item Quality of Recovery Score (QoR-40 score) as well as the consumption of sufentanil and remifentanil during surgery and the incidence of postoperative nausea and vomiting (PONV) were recorded before surgery (T0), 24 h after surgery (T1) and 48 h after surgery (T2). Results The global QoR-40 scores and the scores for physical comfort, physical independence, psychological support and pain at T1 and T2 in two groups as well as the score for emotional state at T1 in group C were significantly lower than those at T0 (P<0.05). Compared with those in group C, the global QoR-40 scores and the scores for physical comfort, emotional state, and pain significantly increased in group L at T1 and T2 (P<0.05), where the score for physical independence in group L was superior to that in group C at T1 (P<0.05). Compared with those in group C, the dosage of remifentanil used during surgery and the incidence of PONV within 48 h in group L significantly reduced (P<0.05). Conclusions Perioperative intravenous lidocaine infusion can improve QoR-40 scores in patients two days after upper airway surgery, reduce the dosage of opioids and the incidence of PONV and improve postoperative early recovery quality. Key words: Lidocaine; Upper airway surgery; 40-item Quality of Recovery Score; Postoperative nausea and vomiting
{"title":"Effect of perioperative intravenous lidocaine infusion on postoperative early recovery quality in patients undergoing upper airway surgery","authors":"Qiaoheng Wang, D. Huai, Weibing Zhao, Xuefang Zhu, Xiaojun Ding, Jun Wang, Chenglan Xie","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.006","url":null,"abstract":"Objective \u0000To investigate the effect of perioperative intravenous lidocaine infusion on postoperative early recovery quality in patients undergoing upper airway surgery. \u0000 \u0000 \u0000Methods \u0000One hundred and twenty patients undergoing upper airway surgery were divided into two groups according to a random number table: a lidocaine group (group L) and a control group (group C), with 60 patients in each group. Group L was administered with 2.0 mg/kg lidocaine over 10 min before induction of anesthesia, followed by intravenous infusion at 2 mg·kg-1· h-1 until the end of surgery. Group C was given the same volume of normal saline. The 40-item Quality of Recovery Score (QoR-40 score) as well as the consumption of sufentanil and remifentanil during surgery and the incidence of postoperative nausea and vomiting (PONV) were recorded before surgery (T0), 24 h after surgery (T1) and 48 h after surgery (T2). \u0000 \u0000 \u0000Results \u0000The global QoR-40 scores and the scores for physical comfort, physical independence, psychological support and pain at T1 and T2 in two groups as well as the score for emotional state at T1 in group C were significantly lower than those at T0 (P<0.05). Compared with those in group C, the global QoR-40 scores and the scores for physical comfort, emotional state, and pain significantly increased in group L at T1 and T2 (P<0.05), where the score for physical independence in group L was superior to that in group C at T1 (P<0.05). Compared with those in group C, the dosage of remifentanil used during surgery and the incidence of PONV within 48 h in group L significantly reduced (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Perioperative intravenous lidocaine infusion can improve QoR-40 scores in patients two days after upper airway surgery, reduce the dosage of opioids and the incidence of PONV and improve postoperative early recovery quality. \u0000 \u0000 \u0000Key words: \u0000Lidocaine; Upper airway surgery; 40-item Quality of Recovery Score; Postoperative nausea and vomiting","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43718592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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