Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.002
Y. Ge, Jie Chen, Xiuzhe Wang, Liyong Yuan
Objective To investigate the effects of salidroside (SAL) on the cognitive function and expression of nuclear factor-κB(NF-κB), hypoxia-inducible factor-1α (HIF-1α) and apoptosis-related proteins in the hippocampus of aged mice after partial hepatectomy, and to discusse the role of NF-κB, HIF-1α and apoptosis-related proteins [B-cell lymphoma-2 (Bcl-2), Bcl-2 related X protein (Bax) and caspase-3] in the pathogenesis of post-operative cognitive dysfunction (POCD). Methods Forty eight healthy male C57B/6 mice, aged 18 months, weight 25-35 g, were used in the study. These mice were randomly divided into three groups (n=16), using a random number table: a sham operation group (a sham group), an operation+normal saline group (an operation group) and a SAL group. Each group was subdivided into two groups (n=8) according to the test time points after operation: a 1 d after operation group and a 3 d after operation group. An operation model was established by partial hepatectomy in the operation and SAL groups. Mice in the SAL group were intraperitoneally injected with SAL. Mice in the sham group were incised and sutured at the same surgical site with partial hepatectomy. The Morris water maze was used to determine learning and memory ability. The hippocampi of these mice were isolated for detection of the expression of NF-κB, HIF-1α, Bcl-2, Bax and caspase-3 by Western blot. Results Compared with those in the sham group, the escape latency for mice in the operation group 1 and 3 days after operation obviously prolonged and the times to cross the platform decreased. Further-more, the expression of hippocampal NF-κB, HIF-1α, Bax and caspase-3 significantly increased, with a decreased level of Bcl-2 (P< 0.01). Compared with those in the operation group, the escape latency of the SAL group obviously decreased and the times to cross the platform increased. The expression of hippocampal NF-κB, HIF-1α, Bax and caspase-3 significantly decreased, with an increased level of Bcl-2 (P<0.05). Conclusions The pathogensis of POCD is associated with the expression of hippocampal NF-κB, HIF-1α and apoptosis-related proteins. SAL can improve the cognitive function of mice after partial hepatectomy through inhibiting the expression of NF-κB, HIF-1α and apoptosis-related proteins. Key words: Salidroside; Nuclear factor-κB; Hypoxia inducible factor-1α; Apoptosis, neurons; Post-operative cognitive dysfunction
{"title":"Effects of salidroside on the cognitive function and expression of nuclear factor-κB, hypoxia-inducible factor-1α, apopto- sis-related proteins after operation","authors":"Y. Ge, Jie Chen, Xiuzhe Wang, Liyong Yuan","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.002","url":null,"abstract":"Objective \u0000To investigate the effects of salidroside (SAL) on the cognitive function and expression of nuclear factor-κB(NF-κB), hypoxia-inducible factor-1α (HIF-1α) and apoptosis-related proteins in the hippocampus of aged mice after partial hepatectomy, and to discusse the role of NF-κB, HIF-1α and apoptosis-related proteins [B-cell lymphoma-2 (Bcl-2), Bcl-2 related X protein (Bax) and caspase-3] in the pathogenesis of post-operative cognitive dysfunction (POCD). \u0000 \u0000 \u0000Methods \u0000Forty eight healthy male C57B/6 mice, aged 18 months, weight 25-35 g, were used in the study. These mice were randomly divided into three groups (n=16), using a random number table: a sham operation group (a sham group), an operation+normal saline group (an operation group) and a SAL group. Each group was subdivided into two groups (n=8) according to the test time points after operation: a 1 d after operation group and a 3 d after operation group. An operation model was established by partial hepatectomy in the operation and SAL groups. Mice in the SAL group were intraperitoneally injected with SAL. Mice in the sham group were incised and sutured at the same surgical site with partial hepatectomy. The Morris water maze was used to determine learning and memory ability. The hippocampi of these mice were isolated for detection of the expression of NF-κB, HIF-1α, Bcl-2, Bax and caspase-3 by Western blot. \u0000 \u0000 \u0000Results \u0000Compared with those in the sham group, the escape latency for mice in the operation group 1 and 3 days after operation obviously prolonged and the times to cross the platform decreased. Further-more, the expression of hippocampal NF-κB, HIF-1α, Bax and caspase-3 significantly increased, with a decreased level of Bcl-2 (P< 0.01). Compared with those in the operation group, the escape latency of the SAL group obviously decreased and the times to cross the platform increased. The expression of hippocampal NF-κB, HIF-1α, Bax and caspase-3 significantly decreased, with an increased level of Bcl-2 (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The pathogensis of POCD is associated with the expression of hippocampal NF-κB, HIF-1α and apoptosis-related proteins. SAL can improve the cognitive function of mice after partial hepatectomy through inhibiting the expression of NF-κB, HIF-1α and apoptosis-related proteins. \u0000 \u0000 \u0000Key words: \u0000Salidroside; Nuclear factor-κB; Hypoxia inducible factor-1α; Apoptosis, neurons; Post-operative cognitive dysfunction","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48137680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the effect of dexmedetomidine (Dex) or epidural blockade combined with general anesthesia on perioperative inflammatory cytokines in lung cancer patients undergoing video-assisted thoracoscopic surgery. Methods Ninety lung cancer patients [American Society of Anesthesiologists (ASA) Ⅰ-Ⅲ , age<70 years] undergoing video-assisted thoracoscopic surgery were divided into three groups according to a random number table: a general anesthesia group (group G), an epidural blockade combined with general anesthesia group (group GE) and a Dex combined with general anesthesia group (group GD), with 30 patients in each group. Patients in group GE underwent epidural catheterization at T7-T8 before anesthesia induction, while groups G and GD was given normal saline or 1 μg/kg Dex via an intravenous infusion pump over 10 min after anesthesia induction. Before induction (T0), at the end of surgery (T1), and 24 h after surgery postoperatively (T3), blood samples from the right internal jugular vein were taken to measure the levels of interleukins (IL-1β, IL-6, and IL-10) and tumor necrosis factor-α (TNF-α) by a double antibody sandwich ABC-ELISA method. The scores of Prince-Henry Pain Scale were evaluated 2 h after surgery (T2) and T3. The incidences of intraoperative hypotension, bradycardia and postoperative nausea and vomiting were recorded. Results Compared with those at T0, there were significant increases in the levels of IL-1 β , IL-6, and TNF-α and sharp decreases in the levels of IL-10 at T1 and T3 in all groups (P 0.05). The scores of Prince-Henry Pain Scale in group GE were lower than those in other two groups (P< 0.05). The incidence of nausea in groups GD and GE was significant lower than that in group G (P<0.05). Conclusions For lung cancer patients undergoing video-assisted thoracoscopic surgery under general anesthesia, a combined use of 1 μg/kg Dex can significantly relieve inflammatory response, to an extent comparable to epidural blockade combined with general anesthesia. Key words: Dexmedetomidine; Anesthesia, epidural; Anesthesia, general; Inflammation; Thoracoscopes; Lung cancer
目的探讨右美托咪定或硬膜外阻滞联合全身麻醉对肺癌胸腔镜手术患者围术期炎症因子的影响。方法90例经电视胸腔镜手术治疗的肺癌患者[美国麻醉医师学会(ASA)Ⅰ-Ⅲ，年龄<70岁]，按随机数字表分为全麻组(G组)、硬膜外阻滞联合全麻组(GE组)和右炔醇双胍联合全麻组(GD组)，每组30例。GE组患者于麻醉诱导前T7-T8行硬膜外置管，G组和GD组患者在麻醉诱导后10 min以上给予生理盐水或1 μg/kg右美托咪唑静脉泵输注。诱导前(T0)、手术结束时(T1)、术后24 h (T3)取右颈内静脉血样，采用双抗体夹心法(ab - elisa)检测白细胞介素(IL-1β、IL-6、IL-10)和肿瘤坏死因子-α (TNF-α)水平。分别于术后2 h (T2)和T3进行Prince-Henry疼痛量表评分。记录术中低血压、心动过缓及术后恶心呕吐的发生率。结果与T0时比较，T1、T3时各组大鼠血清IL-1 β、IL-6、TNF-α水平均显著升高，IL-10水平均显著降低(P < 0.05)。GE组疼痛量表评分低于其他两组(P< 0.05)。GD组和GE组恶心发生率显著低于G组(P<0.05)。结论全麻下肺癌胸腔镜手术患者联合应用1 μg/kg右美托咪定可显著缓解炎症反应，其程度可与硬膜外阻滞联合全麻相当。关键词:右美托咪定;硬膜外麻醉;麻醉,一般;炎症;胸腔镜;肺癌
{"title":"Effect of dexmedetomidine or epidural blockade combined with general anesthesia on perioperative inflammatory cytokines in lung cancer patients undergoing video-assisted thoracoscopic surgery","authors":"Yuwei Qiu, Zheng-lan Zhao, Jingxiang Wu, Yungang Lu, Meiying Xu","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.010","url":null,"abstract":"Objective \u0000To investigate the effect of dexmedetomidine (Dex) or epidural blockade combined with general anesthesia on perioperative inflammatory cytokines in lung cancer patients undergoing video-assisted thoracoscopic surgery. \u0000 \u0000 \u0000Methods \u0000Ninety lung cancer patients [American Society of Anesthesiologists (ASA) Ⅰ-Ⅲ , age<70 years] undergoing video-assisted thoracoscopic surgery were divided into three groups according to a random number table: a general anesthesia group (group G), an epidural blockade combined with general anesthesia group (group GE) and a Dex combined with general anesthesia group (group GD), with 30 patients in each group. Patients in group GE underwent epidural catheterization at T7-T8 before anesthesia induction, while groups G and GD was given normal saline or 1 μg/kg Dex via an intravenous infusion pump over 10 min after anesthesia induction. Before induction (T0), at the end of surgery (T1), and 24 h after surgery postoperatively (T3), blood samples from the right internal jugular vein were taken to measure the levels of interleukins (IL-1β, IL-6, and IL-10) and tumor necrosis factor-α (TNF-α) by a double antibody sandwich ABC-ELISA method. The scores of Prince-Henry Pain Scale were evaluated 2 h after surgery (T2) and T3. The incidences of intraoperative hypotension, bradycardia and postoperative nausea and vomiting were recorded. \u0000 \u0000 \u0000Results \u0000Compared with those at T0, there were significant increases in the levels of IL-1 β , IL-6, and TNF-α and sharp decreases in the levels of IL-10 at T1 and T3 in all groups (P 0.05). The scores of Prince-Henry Pain Scale in group GE were lower than those in other two groups (P< 0.05). The incidence of nausea in groups GD and GE was significant lower than that in group G (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000For lung cancer patients undergoing video-assisted thoracoscopic surgery under general anesthesia, a combined use of 1 μg/kg Dex can significantly relieve inflammatory response, to an extent comparable to epidural blockade combined with general anesthesia. \u0000 \u0000 \u0000Key words: \u0000Dexmedetomidine; Anesthesia, epidural; Anesthesia, general; Inflammation; Thoracoscopes; Lung cancer","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44529863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.011
Yuqin Zhang, Yuanhai Li, Xiaoqiong Xia, S. Xia, Xianzhong Zha, Qing-mei Zhang, Liang Wang
Objective To investigate the effect of perioperative parecoxib sodium combined with dexmedetomidine (Dex) on the gastrointestinal function of elderly patients after laparoscopic gastric cancer surgery. Methods Ninety gastric cancer patients scheduled for laparoscopic surgery, aged 65-85, American Society of Anesthesiologists (ASA) class Ⅰ or Ⅱ were enrolled. They were divided into three groups by the random number table method (30 patients in each group): a parecoxib sodium group (group P), a Dex group (group D), and a combination group (group PD). Then, 15 min before anesthesia induction, patients in groups P and PD were intravenously infused with parecoxib sodium 40 mg diluted with normal saline into 5 ml. Patients in groups D and PD were injected with Dex at a loading dose of 1 μg/kg for 10 min, which was maintained by 0.3 μg·kg-1·min-1 pump infusion, and the infusion was stopped 30 min before the end of operation. All patients were treated with sufentanil plus flurbiprofen injection for intravenous controlled analgesia. Blood samples were collected from the radial artery 15 min before anesthesia (T0), 1 h after the beginning of surgery (T1) and at the end of surgery (T2) respectively. Inflammatory factors [interleukin (IL)-2, IL-6, and tumor necrosis factor-α (TNF-α)] were detected by enzyme-linked immunosorbent assay (ELISA). The time of the first postoperative ventilation, time to take fluid diet, time of getting out of bed, postoperative length of hospitalization stay, hospitalization expenses, Visual Analogue Scale (VAS) scores at rest and during movement (2, 12 h and 24 h after surgery) and postoperative complications were recorded. Results Compared with those at T0, patients in the three groups produced remarkably increased levels of IL-6 and TNF-α as well as significantly decreased levels of IL-2 at T1 and T2 (P<0.05). At T1 and T2, group PD produced remarkably lower levels of IL-6 and TNF-α and higher levels of IL-2 than groups P and D (P<0.05). In the PD group, the time of the first postoperative ventilation, time to take fluid diet, time of getting out of bed, postoperative length of hospitalization stay and hospitalization expenses were all lower than those in groups P and D (P<0.05). The incidence of postoperative complications in the PD group was lower than those in groups P and D (P<0.05). Conclusions Parecoxib sodium combined with Dex can effectively relieve inflammatory stress response after laparoscopic gastric cancer surgery in elderly patients, facilitate rapid recovery of the gastrointestinal tract, and reduce postoperative length of hospitalization stay, hospitalization expenses and postoperative complications. Key words: Parecoxib sodium; Dexmedetomidine; Aged; Therapeutic laparoscopy; Gastrointestinal surgery
{"title":"Effect of perioperative parecoxib sodium combined with dexmedetomidine on the gastrointestinal function of elderly patients after laparoscopic gastric cancer surgery","authors":"Yuqin Zhang, Yuanhai Li, Xiaoqiong Xia, S. Xia, Xianzhong Zha, Qing-mei Zhang, Liang Wang","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.011","url":null,"abstract":"Objective \u0000To investigate the effect of perioperative parecoxib sodium combined with dexmedetomidine (Dex) on the gastrointestinal function of elderly patients after laparoscopic gastric cancer surgery. \u0000 \u0000 \u0000Methods \u0000Ninety gastric cancer patients scheduled for laparoscopic surgery, aged 65-85, American Society of Anesthesiologists (ASA) class Ⅰ or Ⅱ were enrolled. They were divided into three groups by the random number table method (30 patients in each group): a parecoxib sodium group (group P), a Dex group (group D), and a combination group (group PD). Then, 15 min before anesthesia induction, patients in groups P and PD were intravenously infused with parecoxib sodium 40 mg diluted with normal saline into 5 ml. Patients in groups D and PD were injected with Dex at a loading dose of 1 μg/kg for 10 min, which was maintained by 0.3 μg·kg-1·min-1 pump infusion, and the infusion was stopped 30 min before the end of operation. All patients were treated with sufentanil plus flurbiprofen injection for intravenous controlled analgesia. Blood samples were collected from the radial artery 15 min before anesthesia (T0), 1 h after the beginning of surgery (T1) and at the end of surgery (T2) respectively. Inflammatory factors [interleukin (IL)-2, IL-6, and tumor necrosis factor-α (TNF-α)] were detected by enzyme-linked immunosorbent assay (ELISA). The time of the first postoperative ventilation, time to take fluid diet, time of getting out of bed, postoperative length of hospitalization stay, hospitalization expenses, Visual Analogue Scale (VAS) scores at rest and during movement (2, 12 h and 24 h after surgery) and postoperative complications were recorded. \u0000 \u0000 \u0000Results \u0000Compared with those at T0, patients in the three groups produced remarkably increased levels of IL-6 and TNF-α as well as significantly decreased levels of IL-2 at T1 and T2 (P<0.05). At T1 and T2, group PD produced remarkably lower levels of IL-6 and TNF-α and higher levels of IL-2 than groups P and D (P<0.05). In the PD group, the time of the first postoperative ventilation, time to take fluid diet, time of getting out of bed, postoperative length of hospitalization stay and hospitalization expenses were all lower than those in groups P and D (P<0.05). The incidence of postoperative complications in the PD group was lower than those in groups P and D (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Parecoxib sodium combined with Dex can effectively relieve inflammatory stress response after laparoscopic gastric cancer surgery in elderly patients, facilitate rapid recovery of the gastrointestinal tract, and reduce postoperative length of hospitalization stay, hospitalization expenses and postoperative complications. \u0000 \u0000 \u0000Key words: \u0000Parecoxib sodium; Dexmedetomidine; Aged; Therapeutic laparoscopy; Gastrointestinal surgery","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46492248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2020.01.004
Jianqi Wei, Huihui Liu, Cai-neng Wu
Objective To investigate the effect of acupuncture on hemodynamics in chronic myocardial ischemia rats during induction of anesthesia. Methods Forty five Sprague-Dawley rats, weight 200-250 g, were divided into three groups according to a random number table (n=15): a normal control group (group NC), a chronic myocardial ischemia group (group HR) and an acupuncture group (group A-HR). After acupuncture intervention of myocardial ischemia modeled animals for four weeks, the rats received induction of anesthesia with 0.1% propofol at 9 mg/kg via the jugular vein. Subsequently, the mean arterial pressure (MBP), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), the maximal rate of rise/decline of left ventricula pressure (±dp/dt), heart rate, and superoxide dismutase (SOD), malondialdehyde (MDA), creatine kinase isoenzyme (CK-MB) and the morphological changes of myocardial tissues were measured. Results Compared with those in group NC, LVSP, ±dp/dt and MBP remarkably declined in group HR (P<0.05), while LVEDP and heart rate significantly increased in group HR (P<0.05). Compared with group HR, group A-HR presented significantly increased LVSP, +dp/dt and MBP (P<0.05) and significantly decreased heart rate (P<0.05). Compared with group HR, group A-HR produced remarkable decreases in MDA and CK-MB (P<0.05) and marked increases in SOD (P< 0.05). Conclusions Acupuncture pretreatment of rats with myocardial ischemia can regulate and control hemodynamic stabilities during induction of anesthesia, which may be done through inhibiting lipid peroxidation to improves cardiac micro-circulation and reducing the injury of cardiac muscles. Key words: Acupuncture; Myocardial ischemia; Propofol; Anesthesia induction; Hemodynamics
{"title":"Effect of acupuncture on hemodynamics in rats with chronic myocardial ischemia during induction of anesthesia with propofol","authors":"Jianqi Wei, Huihui Liu, Cai-neng Wu","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.004","url":null,"abstract":"Objective \u0000To investigate the effect of acupuncture on hemodynamics in chronic myocardial ischemia rats during induction of anesthesia. \u0000 \u0000 \u0000Methods \u0000Forty five Sprague-Dawley rats, weight 200-250 g, were divided into three groups according to a random number table (n=15): a normal control group (group NC), a chronic myocardial ischemia group (group HR) and an acupuncture group (group A-HR). After acupuncture intervention of myocardial ischemia modeled animals for four weeks, the rats received induction of anesthesia with 0.1% propofol at 9 mg/kg via the jugular vein. Subsequently, the mean arterial pressure (MBP), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), the maximal rate of rise/decline of left ventricula pressure (±dp/dt), heart rate, and superoxide dismutase (SOD), malondialdehyde (MDA), creatine kinase isoenzyme (CK-MB) and the morphological changes of myocardial tissues were measured. \u0000 \u0000 \u0000Results \u0000Compared with those in group NC, LVSP, ±dp/dt and MBP remarkably declined in group HR (P<0.05), while LVEDP and heart rate significantly increased in group HR (P<0.05). Compared with group HR, group A-HR presented significantly increased LVSP, +dp/dt and MBP (P<0.05) and significantly decreased heart rate (P<0.05). Compared with group HR, group A-HR produced remarkable decreases in MDA and CK-MB (P<0.05) and marked increases in SOD (P< 0.05). \u0000 \u0000 \u0000Conclusions \u0000Acupuncture pretreatment of rats with myocardial ischemia can regulate and control hemodynamic stabilities during induction of anesthesia, which may be done through inhibiting lipid peroxidation to improves cardiac micro-circulation and reducing the injury of cardiac muscles. \u0000 \u0000 \u0000Key words: \u0000Acupuncture; Myocardial ischemia; Propofol; Anesthesia induction; Hemodynamics","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"23 1","pages":"18-21"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69886442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2019.12.003
B. Qi, Song Zhang, Peiying Li, Lingke Chen, Liqun Yang
Objective To evaluate the effects of remote ischemic preconditioning (RIPC) on the ischemia/reperfusion injury (I/RI) and early outcome of biliary atresia (BA) child patients receiving living donor liver transplantation. Methods Ninety BA child patients receiving living donor liver transplantation were randomly divided into two groups (n=45): a control group and an RIPC group. Before surgery, patients in the RIPC group were tied with tourniquets at the right lower extremity before inflation to 150 mmHg (1 mmHg=0.133 kPa) for 5 min, followed by deflation over 5 min for re-infusion of the leg. The cycle was repeated three times. Then, their levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) before surgery and 2 h, 1 day and 3 days after surgery were examined. Moreover, their intensive care unit(ICU) stay, total hospitalization stay, the percentage of re-transplantation, and the mortality within one year were recorded. Results No differences were found between the two groups in ALT and AST levels before surgery and 2 h, 1 day and 3 days after surgery. There was also no statistical difference between the two groups in the incidence of main complication after surgery. Compared with the control group, the RIPC group presented decreases in ICU stay and total hospitalization stay without statistical differences (P>0.05). No statistical differences were found in the mortality of one year after surgery between the two groups. Conclusions The current study does not demonstrate the protective effects of RIPC on BA child patients receiving liver transplantation. Extended follow-up visits, an increased number of evaluation indicators and alternation of RIPC parameters will be useful to determine the clinical efficacy of RIPC in BA child patients during liver transplantation. Key words: Biliary atresia; Liver transplantation; Remote ischemic preconditioning; Ischemia/reperfusion injury
{"title":"Effects of remote ischemic preconditioning on the prognosis of biliary atresia child patients receiving living donor liver transplantation","authors":"B. Qi, Song Zhang, Peiying Li, Lingke Chen, Liqun Yang","doi":"10.3760/CMA.J.ISSN.1673-4378.2019.12.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2019.12.003","url":null,"abstract":"Objective \u0000To evaluate the effects of remote ischemic preconditioning (RIPC) on the ischemia/reperfusion injury (I/RI) and early outcome of biliary atresia (BA) child patients receiving living donor liver transplantation. \u0000 \u0000 \u0000Methods \u0000Ninety BA child patients receiving living donor liver transplantation were randomly divided into two groups (n=45): a control group and an RIPC group. Before surgery, patients in the RIPC group were tied with tourniquets at the right lower extremity before inflation to 150 mmHg (1 mmHg=0.133 kPa) for 5 min, followed by deflation over 5 min for re-infusion of the leg. The cycle was repeated three times. Then, their levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) before surgery and 2 h, 1 day and 3 days after surgery were examined. Moreover, their intensive care unit(ICU) stay, total hospitalization stay, the percentage of re-transplantation, and the mortality within one year were recorded. \u0000 \u0000 \u0000Results \u0000No differences were found between the two groups in ALT and AST levels before surgery and 2 h, 1 day and 3 days after surgery. There was also no statistical difference between the two groups in the incidence of main complication after surgery. Compared with the control group, the RIPC group presented decreases in ICU stay and total hospitalization stay without statistical differences (P>0.05). No statistical differences were found in the mortality of one year after surgery between the two groups. \u0000 \u0000 \u0000Conclusions \u0000The current study does not demonstrate the protective effects of RIPC on BA child patients receiving liver transplantation. Extended follow-up visits, an increased number of evaluation indicators and alternation of RIPC parameters will be useful to determine the clinical efficacy of RIPC in BA child patients during liver transplantation. \u0000 \u0000 \u0000Key words: \u0000Biliary atresia; Liver transplantation; Remote ischemic preconditioning; Ischemia/reperfusion injury","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"40 1","pages":"1105-1109"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42551905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2019.12.012
Li Zenghui, Jie Song, Lei Yao
In recent years, a variety of surgically-induced nociceptive monitoring systems have been proposed to maintain optimal analgesic balance. Surgical pleth index(SPI) is a monitoring tool obtained from finger photo plethysmography signals used to detect the balance between nociceptive and analgesic administration during general anesthesia. In this review, we summarized the application of SPI monitoring in clinical anesthesia in recent years. SPI monitoring improved the judgment of nociceptive sensation in anesthesia and provided reference for the analgesic level of anesthesia. Key words: Anesthesia; Monitoring; Surgical pleth index; Analgesia
{"title":"Application of surgical pleth index in clinical anesthesia","authors":"Li Zenghui, Jie Song, Lei Yao","doi":"10.3760/CMA.J.ISSN.1673-4378.2019.12.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2019.12.012","url":null,"abstract":"In recent years, a variety of surgically-induced nociceptive monitoring systems have been proposed to maintain optimal analgesic balance. Surgical pleth index(SPI) is a monitoring tool obtained from finger photo plethysmography signals used to detect the balance between nociceptive and analgesic administration during general anesthesia. In this review, we summarized the application of SPI monitoring in clinical anesthesia in recent years. SPI monitoring improved the judgment of nociceptive sensation in anesthesia and provided reference for the analgesic level of anesthesia. \u0000 \u0000 \u0000Key words: \u0000Anesthesia; Monitoring; Surgical pleth index; Analgesia","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"40 1","pages":"1141-1145"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47572372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2019.12.001
Yuhua Fan, Zhengnian Ding, Yonghao Yu, Hao Yu, Hong Ma, Yu Ma, J. Cang, Ya-ping Wang, Hai-yan Wang, Jun Wang, Kun Tian, Ya-ni Feng, Ke-xuan Liu, Hao Cheng, M. Yan, Min Li, Cairong Li, Junjun Chen, Li-chang Chen, Junbei Wu, Yanying Xiao, Mengchang Yang, Yuanyuan Zhang, Chongliang Fang, S. Yao, Hongli Yu, Q. Xia, Xiu-juan Qin, Guangmin Xu, Shu-kun Fu, Fuhai Ji, S. Cai, Xin-xue Liao, Xin-chuan Wei, Guohua Wei, Xin Wei, Xiaoming Deng
Objective To compare the efficacy and safety of glycopyrrolate versus atropine against bradycardia induced by neostigmine. Methods Patients scheduled for elective non-cardiac surgery were central randomly assigned to experimental group(n=123) and control group (n=124). Patients in experimental group were administered with glycopyrrolate at a dose of 0.008 mg/kg and neostigmine 0.04 mg/kg in 1 minute, whereas patients in control group received atropine at a dose of 0.016 mg/kg and neostigmine 0.04 mg/kg in 1 min to antagonize the remained neuromuscular block effect at the end of operation, respectively. Heart rate was recorded for 15 min after administration of the antagonized mixture, the area under the time curve(AUC) of the difference between heart rate and baseline heart rate, heart rate per minute and the difference between heart rate and baseline heart rate were compared. The dose of atropine for rescue therapy after administration was also recorded. Also, the adverse events within 24 h after operation were followed and compared. Results The AUC of the difference between heart rate and baseline heart rate was smaller in experimental group than the AUC in control group (P 0.05). Conclusions The effects of glycopyrrolate and atropine on preventing bradycardia when given in a mixture with neostigmine for the reversal of non-depolarizing neuromuscular block were compared. Glycopyrrolate has better effect than atropine for maintaining heart rate stability. Key words: Glycopyrrolate; Atropine; Neostigmine; Bradycardia
{"title":"Prevention of glycopyrrolate against bradycardia induced by neostigmine: a multicenter, randomized, double-blind, doubledummy, parallel-controlled clinical trial","authors":"Yuhua Fan, Zhengnian Ding, Yonghao Yu, Hao Yu, Hong Ma, Yu Ma, J. Cang, Ya-ping Wang, Hai-yan Wang, Jun Wang, Kun Tian, Ya-ni Feng, Ke-xuan Liu, Hao Cheng, M. Yan, Min Li, Cairong Li, Junjun Chen, Li-chang Chen, Junbei Wu, Yanying Xiao, Mengchang Yang, Yuanyuan Zhang, Chongliang Fang, S. Yao, Hongli Yu, Q. Xia, Xiu-juan Qin, Guangmin Xu, Shu-kun Fu, Fuhai Ji, S. Cai, Xin-xue Liao, Xin-chuan Wei, Guohua Wei, Xin Wei, Xiaoming Deng","doi":"10.3760/CMA.J.ISSN.1673-4378.2019.12.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2019.12.001","url":null,"abstract":"Objective \u0000To compare the efficacy and safety of glycopyrrolate versus atropine against bradycardia induced by neostigmine. \u0000 \u0000 \u0000Methods \u0000Patients scheduled for elective non-cardiac surgery were central randomly assigned to experimental group(n=123) and control group (n=124). Patients in experimental group were administered with glycopyrrolate at a dose of 0.008 mg/kg and neostigmine 0.04 mg/kg in 1 minute, whereas patients in control group received atropine at a dose of 0.016 mg/kg and neostigmine 0.04 mg/kg in 1 min to antagonize the remained neuromuscular block effect at the end of operation, respectively. Heart rate was recorded for 15 min after administration of the antagonized mixture, the area under the time curve(AUC) of the difference between heart rate and baseline heart rate, heart rate per minute and the difference between heart rate and baseline heart rate were compared. The dose of atropine for rescue therapy after administration was also recorded. Also, the adverse events within 24 h after operation were followed and compared. \u0000 \u0000 \u0000Results \u0000The AUC of the difference between heart rate and baseline heart rate was smaller in experimental group than the AUC in control group (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The effects of glycopyrrolate and atropine on preventing bradycardia when given in a mixture with neostigmine for the reversal of non-depolarizing neuromuscular block were compared. Glycopyrrolate has better effect than atropine for maintaining heart rate stability. \u0000 \u0000 \u0000Key words: \u0000Glycopyrrolate; Atropine; Neostigmine; Bradycardia","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"40 1","pages":"1094-1098"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42811637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2019.12.004
Q. Gao, Yongtao Gao, Zhi Yin, Zhen-zhen Yuan
Objective To observe the effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation (OLV). Methods Forty-two patients with thoracic esophageal cancer undergoing elective resection were enrolled in the study and divided into two groups (n=21): a test group (group T) and a control group (group C) according to the random number table. When OLV started, group T received atomizing inhalation of alprostadil 0.2 μg/kg via the left lung, while group C received the same amount of normal saline. Radial arterial blood samples were taken 3 min before OLV (T1), 3 min after OLV (T2), and 30 min after T2(T3) for blood gas analysis and oxygenation index (OI) and pulmonary shunt rate (Qs/Qt) were calculated. The hemodynamic indexes of the two groups were recorded at these points. Results Patients in both groups presented remarkable decreases in OI values and marked increases in Qs/Qt at T2 and T3 compared with those at T1(P 0.05). Conclusions Atomizing inhalation of alprostadil during OLV towards ventilated lungs can improve oxygenation function and decrease intrapulmonary shunt in patients after OLV. Key words: One lung ventilation; Alprostadil; Oxygenation function
{"title":"Effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation","authors":"Q. Gao, Yongtao Gao, Zhi Yin, Zhen-zhen Yuan","doi":"10.3760/CMA.J.ISSN.1673-4378.2019.12.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2019.12.004","url":null,"abstract":"Objective \u0000To observe the effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation (OLV). \u0000 \u0000 \u0000Methods \u0000Forty-two patients with thoracic esophageal cancer undergoing elective resection were enrolled in the study and divided into two groups (n=21): a test group (group T) and a control group (group C) according to the random number table. When OLV started, group T received atomizing inhalation of alprostadil 0.2 μg/kg via the left lung, while group C received the same amount of normal saline. Radial arterial blood samples were taken 3 min before OLV (T1), 3 min after OLV (T2), and 30 min after T2(T3) for blood gas analysis and oxygenation index (OI) and pulmonary shunt rate (Qs/Qt) were calculated. The hemodynamic indexes of the two groups were recorded at these points. \u0000 \u0000 \u0000Results \u0000Patients in both groups presented remarkable decreases in OI values and marked increases in Qs/Qt at T2 and T3 compared with those at T1(P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Atomizing inhalation of alprostadil during OLV towards ventilated lungs can improve oxygenation function and decrease intrapulmonary shunt in patients after OLV. \u0000 \u0000 \u0000Key words: \u0000One lung ventilation; Alprostadil; Oxygenation function","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"40 1","pages":"1110-1112"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43685868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2019.12.013
Xue Dong, Keshi Yan, Ju Gao
Lung ultrasound(LUS) has been widely used in the diagnosis of pulmonary diseases. However, the role of LUS in lung-protective ventilation strategy of the diagnosis and treatment in patients with pulmonary complications combined with acute respiratory distress syndrome/acute lung injury(ARDS/ALI) is still not clear. This review presents the research advances of diagnosis and therapy of pulmonary diseases as well as value of the LUS in lung-protective ventilation strategy in recent years. Through further investigation, the significance of clinical application of LUS will be confirmed. Application of LUS in the lung-protection ventilation strategy reduces the incidence of postoperative pulmonary complications and mortality and improves the prognosis of patients. Key words: Lung; Ultrasoud; Disease diagnosis; Lung-protective ventilation strategy; Acute respiratory distress syndrome; Acute lung injury
{"title":"Value in application of lung ultrasound in diagnosis of pulmonary disease and in lung-protective ventilation strategy","authors":"Xue Dong, Keshi Yan, Ju Gao","doi":"10.3760/CMA.J.ISSN.1673-4378.2019.12.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2019.12.013","url":null,"abstract":"Lung ultrasound(LUS) has been widely used in the diagnosis of pulmonary diseases. However, the role of LUS in lung-protective ventilation strategy of the diagnosis and treatment in patients with pulmonary complications combined with acute respiratory distress syndrome/acute lung injury(ARDS/ALI) is still not clear. This review presents the research advances of diagnosis and therapy of pulmonary diseases as well as value of the LUS in lung-protective ventilation strategy in recent years. Through further investigation, the significance of clinical application of LUS will be confirmed. Application of LUS in the lung-protection ventilation strategy reduces the incidence of postoperative pulmonary complications and mortality and improves the prognosis of patients. \u0000 \u0000 \u0000Key words: \u0000Lung; Ultrasoud; Disease diagnosis; Lung-protective ventilation strategy; Acute respiratory distress syndrome; Acute lung injury","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"40 1","pages":"1146-1150"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47371213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1673-4378.2019.12.010
Min Zhao, Pin Zhao, N. Ge, Shan-Feng Zhang, Jianke Kuai
Objective To observe the effects of docosahexenoic acid (DHA) on sevoflurane-induced Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB) pathway activation and the release of inflammatory mediators. Metheds N9 cells were assigned to a CON group, a Sevo group and a DHA+Sevo group. After 24 h treatment, cell survival was assessed by methylthiazolyldiphenyl-tetrazolium bromide(MTT) assay. Western blot was used to detect the levels of microglial TLR4, MyD88 and inhibitor of NF-κB-α(IκB-α), while the contents of inflammatory mediator tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and IL-10 in each group were detected by enzyme-linked immunosorbent assay (ELISA). Results Compared with the CON group, the survival rate of N9 cells in the Sevo group decreased significantly, while the level of TLR4 and MyD88 protein was increased significantly, the level of IκB-α was significantly decreased, the release of TNF-α and IL-1β and IL-6 was increased significantly (P<0.05). The amounts of IL-1β and IL-10 were increased significantly in the DHA+Sevo group (P<0.05). Compared with the Sevo group, the survival rate in the DHA+Sevo group increased significantly, the level of TLR4 and MyD88 protein decreased significantly, the level of IκB-α was increased significantly, TNF-α, IL-1β and IL-6 release was increased significantly, while IL-10 release was increased significantly(P<0.05). Conclusions DHA inhibits sevoflurane-induced cell damage and activation of TLR4/MyD88/NF-κB signaling pathway, and reduces the release of pro-inflammatory mediators TNF-α, IL-1β and IL-6, and increases anti-inflammatory mediator IL-10 release. Key words: Docosahexenoic acid; Sevoflurane; Microglia; Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway; Inflammatory mediator
目的观察二十二碳六烯酸(DHA)对七氟醚诱导的toll样受体4 (TLR4)/髓样分化因子88(MyD88)/核因子κ b (NF-κB)通路激活及炎症介质释放的影响。方法将N9个细胞分为CON组、Sevo组和DHA+Sevo组。处理24 h后，采用甲基噻唑基二苯基溴化四氮唑(MTT)法测定细胞存活率。Western blot检测各组小胶质细胞TLR4、MyD88及NF-κB-α抑制剂(i -κB-α)水平，酶联免疫吸附法(ELISA)检测各组炎症介质肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6、IL-10含量。结果与CON组比较，Sevo组N9细胞存活率显著降低，TLR4、MyD88蛋白水平显著升高，i - κ b -α水平显著降低，TNF-α、IL-1β、IL-6释放量显著升高(P<0.05)。DHA+Sevo组IL-1β、IL-10含量显著升高(P<0.05)。与Sevo组比较，DHA+Sevo组小鼠存活率显著升高，TLR4、MyD88蛋白水平显著降低，i - κ b -α水平显著升高，TNF-α、IL-1β、IL-6释放量显著升高，IL-10释放量显著升高(P<0.05)。结论DHA可抑制七氟醚诱导的细胞损伤和TLR4/MyD88/NF-κB信号通路的激活，减少促炎介质TNF-α、IL-1β和IL-6的释放，增加抗炎介质IL-10的释放。关键词:二十二碳六烯酸;七氟醚;小胶质细胞;toll样受体4/髓样分化因子88/核因子κ b通路;炎性介质
{"title":"Effect of docosahexenoic acid on sevoflurane-induced activation of microglia Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway and the release of inflammatory mediators","authors":"Min Zhao, Pin Zhao, N. Ge, Shan-Feng Zhang, Jianke Kuai","doi":"10.3760/CMA.J.ISSN.1673-4378.2019.12.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2019.12.010","url":null,"abstract":"Objective \u0000To observe the effects of docosahexenoic acid (DHA) on sevoflurane-induced Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB) pathway activation and the release of inflammatory mediators. \u0000 \u0000 \u0000Metheds \u0000N9 cells were assigned to a CON group, a Sevo group and a DHA+Sevo group. After 24 h treatment, cell survival was assessed by methylthiazolyldiphenyl-tetrazolium bromide(MTT) assay. Western blot was used to detect the levels of microglial TLR4, MyD88 and inhibitor of NF-κB-α(IκB-α), while the contents of inflammatory mediator tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and IL-10 in each group were detected by enzyme-linked immunosorbent assay (ELISA). \u0000 \u0000 \u0000Results \u0000Compared with the CON group, the survival rate of N9 cells in the Sevo group decreased significantly, while the level of TLR4 and MyD88 protein was increased significantly, the level of IκB-α was significantly decreased, the release of TNF-α and IL-1β and IL-6 was increased significantly (P<0.05). The amounts of IL-1β and IL-10 were increased significantly in the DHA+Sevo group (P<0.05). Compared with the Sevo group, the survival rate in the DHA+Sevo group increased significantly, the level of TLR4 and MyD88 protein decreased significantly, the level of IκB-α was increased significantly, TNF-α, IL-1β and IL-6 release was increased significantly, while IL-10 release was increased significantly(P<0.05). \u0000 \u0000 \u0000Conclusions \u0000DHA inhibits sevoflurane-induced cell damage and activation of TLR4/MyD88/NF-κB signaling pathway, and reduces the release of pro-inflammatory mediators TNF-α, IL-1β and IL-6, and increases anti-inflammatory mediator IL-10 release. \u0000 \u0000 \u0000Key words: \u0000Docosahexenoic acid; Sevoflurane; Microglia; Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway; Inflammatory mediator","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"40 1","pages":"1134-1138"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47916556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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