International Journal of Geriatric Psychiatry最新文献

{"title":"Latent Transition and Predictors of Cognitive Function Among Community-Dwelling Chinese Older Adults With Cardiovascular Metabolic Diseases","authors":"Yaqi Wang,&nbsp;Bowen Wan,&nbsp;Xueying Xu,&nbsp;Qingyun Lv,&nbsp;Yuan He,&nbsp;Jingwen Liu,&nbsp;Hairong Chang,&nbsp;Yue Zhao,&nbsp;Li Fu,&nbsp;Xiaoying Zang,&nbsp;Xiaonan Zhang","doi":"10.1002/gps.70144","DOIUrl":"https://doi.org/10.1002/gps.70144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Despite the recognized heterogeneity of cognitive function in older adults and its propensity for transition, this phenomenon remains inadequately understood among older adults with cardiovascular metabolic diseases (CMD). We aimed to explore the latent profiles of cognitive function among older adults with CMD, along with the transition probabilities between profiles and associated predictors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cohort study including 2304 older adults with CMD was drawn from the Chinese Longitudinal Healthy Longevity Survey. Cognitive function assessments and covariate data were gathered in 2011, with cognitive function reassessed in 2014. Latent profile analysis was employed to explore the latent profiles of cognitive function at two time points, latent transition analysis to examine transition probabilities between profiles, and multinomial logistic regression to investigate predictive factors of profile transitions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Latent profile analysis supported 3-profile model: normal cognitive function, mild cognitive impairment, and severe cognitive impairment. Over the 3-year period, the normal cognitive function profile exhibited greater stability, with probabilities of 0.834, while the mild cognitive impairment profile demonstrated a higher likelihood of transitioning to the normal cognitive function profile, with a probability of 0.630. Age, sleep duration, and social participation emerged as predictive factors of profile transitions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Significant heterogeneity exists in cognitive function among older adults with CMD, characterized by three distinct profiles. Varied transition patterns and probabilities underscore the importance of identifying and intervening with individuals at elevated risk of negative transitions, potentially improving their cognitive function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Sensory Impairment and Cognitive Impairment Among Older Adults: Insights From a National Cohort Study in China","authors":"Bingxin Ma,&nbsp;Yan Sun,&nbsp;Qingxian Shen,&nbsp;Yuyang Zhang,&nbsp;Dongrui Wang,&nbsp;Junwei Ma,&nbsp;Xinyi Dong,&nbsp;Yue Zhao,&nbsp;Qi Lu","doi":"10.1002/gps.70139","DOIUrl":"https://doi.org/10.1002/gps.70139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Cognitive impairment and sensory impairment are highly prevalent in older adults, but the relationship between the two remains inconclusive. This study aimed to investigate the relationship between visual impairment (VI), hearing impairment (HI), dual sensory impairment (DSI), and the onset of cognitive impairment among Chinese older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were obtained from the 2011–2018 China Longitudinal Healthy Longevity Survey (CLHLS) cohort. Cognitive impairment was defined using the Chinese version of the Mini-Mental State Examination (CMMSE), with a score below 18 indicating its onset. VI and HI were identified through self-reported questionnaires. Cox proportional hazard regression models were applied to estimate crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the associations between single and dual SI with cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 3239 adults aged 65 and older were analyzed, with 329 participants (10.2%) developing cognitive impairment over 21,039 person-years of follow-up. Participants with single VI (HR 1.42, 95% CI 1.08–1.87), single HI (HR 2.24, 95% CI 1.58–3.15), and DSI (HR 2.08, 95% CI 1.44–3.01) exhibited significantly higher risks of cognitive impairment compared to those without SI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this nationally representative sample of Chinese older adults, VI, HI, and DSI, were significantly associated with an increased risk of cognitive impairment. Future studies are encouraged to employ standardized tools to assess sensory and cognitive impairments, further explore the mechanisms linking the two, and consider the potential benefits of incorporating sensory impairment assessment and management into primary healthcare to reduce the risk of cognitive impairment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and Sex Differences in Adverse Events Associated With Antipsychotics: An Analysis of the FDA Adverse Events Database","authors":"Tabea Ramin,&nbsp;Jens-Uwe Peter,&nbsp;Michael Schneider,&nbsp;Volker Dahling,&nbsp;Oliver Zolk","doi":"10.1002/gps.70142","DOIUrl":"https://doi.org/10.1002/gps.70142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>While the risks of antipsychotics in older adults are well recognized, clinical trials often exclude frail older patients, have short follow-up periods, and provide limited comparative data on specific drugs. This study aimed to explore age-related differences in the adverse effects of six commonly prescribed antipsychotics using a pharmacovigilance database, with additional analysis of sex-based variations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed adverse event (AE) reports associated with aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and haloperidol from the FDA Adverse Event Reporting System (FAERS) database between Q4 2003 and Q2 2024. We utilized Standardized MedDRA Queries (SMQs) and self-defined queries to categorize 18 groups of AEs. Adjusted logistic regression was employed to calculate adjusted reporting odds ratios (aRORs) with 95% confidence intervals (CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our analysis revealed substance-specific differences in AE profiles. Risperidone had the highest aROR for hyperprolactinemia (aROR 212, 95% CI 203–221), haloperidol for dystonia (aROR 46, 95% CI 41–51), and aripiprazole for akathisia (aROR 45, 95% CI 42–49). Patients aged 65 and older generally demonstrated a higher likelihood of experiencing cardiac, extrapyramidal motor, and sedative AEs compared to those under 65, with few exceptions across the drugs investigated. In contrast, younger patients showed higher odds for metabolic AEs, including dyslipidemia and hyperglycemia (associated with olanzapine and quetiapine), as well as weight gain (with olanzapine, quetiapine, risperidone, and haloperidol). With few exceptions, women generally showed higher reporting odds of adverse events. Sex-related differences were especially pronounced for hyperprolactinemia, with 4.7–8.0 times higher reporting odds in women for aripiprazole, olanzapine, quetiapine, and haloperidol—except for risperidone, where a post-2014 rise in male reports led to higher odds in men. Risperidone was also associated with increased reporting odds of weight gain in men. Additionally, aripiprazole and olanzapine showed 3 to 6 times higher reporting odds for anticholinergic syndrome in men compared to women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>It is essential to consider both age and sex in treatment decisions to optimize the efficacy and tolerability of antipsychotic therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma Beliefs and Attitudes Against Dementia and Help-Seeking Intentions in Hypothetical Early Signs of Dementia: An Observational Cross-Sectional Study of Middle-Aged and Older Adults in Japan","authors":"Taiji Noguchi,&nbsp;Erhua Shang,&nbsp;Takahiro Hayashi","doi":"10.1002/gps.70141","DOIUrl":"https://doi.org/10.1002/gps.70141","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>People's stigma toward dementia may hinder support and care in early dementia. We explored the association of stigma beliefs and attitudes toward dementia with help-seeking intentions among middle-aged and older adults in hypothetical early signs of dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study involved individuals aged 40 years and above without dementia, recruited from public facility visitors in Aichi, Japan, between July and August 2024. Dementia stigma was assessed using a short form of the Phillipson Dementia Stigma Assessment, comprising four domains: personal avoidance (avoiding contact and interaction with people with dementia), fear of labeling (fear and anxiety regarding dementia diagnosis), person-centeredness (respect and positive attitudes toward people with dementia), and fear of discrimination (fear of ostracism because of dementia). The participants were asked about their help-seeking intentions from family members, other relatives, healthcare professionals, public facilities, and the phone helpline during the hypothetical early signs of dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data from 380 individuals were analyzed (mean age 75.0 years; 76.1% women), of whom 90.4% had help-seeking intentions from a partner, 85.9% from children, and 85.8% from healthcare professionals. Multivariable regression analysis revealed that higher dementia stigma was associated with a lower likelihood of help-seeking intentions from a partner, children, and healthcare professionals. Of the subdomains, fear of discrimination was negatively related to help-seeking intentions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study indicated that people's stigma beliefs and attitudes may pose barriers to help-seeking in the early stage of dementia. Our findings highlight the need to strengthen support for individuals with early dementia, while reducing people's fear of discrimination and prejudice against dementia in the long term.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144814656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaningful Moments of Connection: How People Affected by Dementia and Their Carers Living at Home Understand, Interpret and Experience Everyday Aesthetics","authors":"Sarah Fox,&nbsp;James Thompson,&nbsp;John Keady","doi":"10.1002/gps.70136","DOIUrl":"https://doi.org/10.1002/gps.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study considers how people affected by dementia living in their own homes understand and interpret everyday aesthetics and what relevance this holds in their everyday lives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nine households, comprising ten family carers and seven people living with dementia, shared their self-identified meaningful moments of connection reflective of their personal understanding and interpretation of everyday aesthetics. Data collection involved a range of creative and self-initiated approaches, including scrapbooking, photography, and elicitation interviews. Data were analysed using reflective thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Six discrete but interlinked themes were identified, namely: (1) Connection with others; (2) Connection with materiality; (3) Connection with self-image; (4) Connection with pride and societal value; (5) Connection with enjoyable activities; and (6) Connection with the lived environment, that revealed how people affected by dementia self-identify everyday aesthetic experiences in their daily lives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Our findings show these self-identified experiences span multiple physical and psychological domains of everyday life, each of which acts to support the personhood and identity of the person living with dementia. We suggest that development of a new model of care based on everyday aesthetic needs and informed by people affected by dementia, might bridge the gap between theory and practice in person-centred care. Going forward, developing care practices and support systems which focus on identifying and fulfilling the aesthetic needs of people living with dementia may offer a novel way to enhancing independence and personal well-being.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inequalities in Dementia Care and Research.","authors":"Pinar Soysal, Andrea Slachevski, Yaohua Chen","doi":"10.1002/gps.70143","DOIUrl":"https://doi.org/10.1002/gps.70143","url":null,"abstract":"","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":"e70143"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “The Influence of a Dementia Diagnosis on Clinical Decision-Making in Dysphagia Management”","authors":"","doi":"10.1002/gps.70133","DOIUrl":"https://doi.org/10.1002/gps.70133","url":null,"abstract":"<p>Table 3 should have the following labels for the columns and rows:</p><p>We apologize for this error.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Health Literacy and Depressive Symptoms With the Mediation Role of Family Health and Perceived Social Support in Older Adults: A Nationwide Cross-Sectional Study in China.","authors":"Shiying Cai, Zijie Zhuang, Weiming Lu, Yifei Wang, Zhiyuan Tian, Jie Ren, Jue Li, Jiaxin Chen, Guangbo Luo, Bin Lin, Xiali Yang","doi":"10.1002/gps.70134","DOIUrl":"https://doi.org/10.1002/gps.70134","url":null,"abstract":"<p><strong>Objectives: </strong>There was a lack of in-depth understanding of the relationship between health literacy and depressive symptoms, and it was also unclear whether family health and perceived social support mediated this relationship and were negatively associated with the presence of depressive symptoms in older adults. This study aimed to explore the relationship between health literacy and depressive symptoms among older adults, while assessing the mediating roles of family health and perceived social support.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in China in 2021, involving 1147 participants aged 60 and older recruited using a nationwide multistage random sampling method. Ordered logistic regression and generalized additive models were employed to examine the association between health literacy and depressive symptoms, and the mediating effects of family health and perceived social support were assessed using mediation analysis with non-parametric bootstrapping. The Karlson-Holm-Breen (KHB) method was used to evaluate combined indirect associations, and subgroup mediation analyses were performed for \"young-old\" (65-74 years) and \"old-old\" (≥ 75 years) participants.</p><p><strong>Results: </strong>Higher health literacy was associated with a lower likelihood of depressive symptoms (OR = 0.98, 95% CI: 0.97-0.99). Mediation analysis showed that the total indirect effect was thus estimated at -0.01, and the total effect of health literacy on depressive symptoms was approximately -0.03. The negative association between health literacy and depressive symptoms, as well as the mediating role of family health, remained significant in both the 65-74 and ≥ 75 age groups. However, the mediating effect of perceived social support was significant only in the 65-74 age group.</p><p><strong>Conclusions: </strong>Health literacy is negatively associated with depressive symptoms in Chinese older adults and could be considered as a focus for intervention strategies. Enhancing health literacy may improve family health and perceived social support, and potentially lower depressive symptoms.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":"e70134"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-Response Association of Handgrip Strength With Alzheimer's Disease: A Longitudinal Study Involving 85,979 Adults","authors":"Rodrigo Núñez-Cortés,&nbsp;Joaquín Calatayud,&nbsp;Sergio Calonge-Pascual,&nbsp;Lars Louis Andersen,&nbsp;Rúni Bláfoss,&nbsp;José Francisco López-Gil,&nbsp;Rubén López-Bueno","doi":"10.1002/gps.70137","DOIUrl":"https://doi.org/10.1002/gps.70137","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the dose-response relationship between handgrip strength and incidence of Alzheimer's disease (AD) in middle-aged and older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Longitudinal study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>A longitudinal study was conducted in people over 50 years old in 27 European countries and Israel. Data were collected from waves 1, 2, 4, 5, 6, 7 and 8 of the Survey of Health, Ageing and Retirement in Europe (SHARE) between February 2004 and January 2021. Handgrip strength was measured with a hand dynamometer. AD was self-reported based on previous diagnosis. Dose-response associations were assessed by restricted cubic splines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 85,979 (55.8% female) participants were followed for a median of 9.3 years. Over this time, 3324 (3.9%) developed AD. In the adjusted model, for participants &lt; 65 years, those in the middle third of handgrip strength showed a lower risk of AD compared to the lower third (HR = 0.63, 95% CI: 0.47–0.84), as well as participants in the upper third (HR = 0.63, 95% CI: 0.47–0.85). The spline model determined that the minimum and optimal doses of handgrip strength for a significant reduction in the risk of AD for those aged &lt; 65 years were 54 kg (HR = 0.99; 95% CI: 0.08–0.99) and 56 kg (HR = 0.27; 95% CI: 0.08–0.91), respectively. Among those aged ≥ 65 years, the minimum and optimal doses were 31 kg (HR = 0.69; 95% CI: 0.48–0.99) and 49 kg (HR = 0.57; 95% CI: 0.43–0.76), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher levels of handgrip strength showed a lower risk of developing AD, among adults aged 50 years and over. However, the dose-response relationship is limited to specific ranges according to age group. We identified a range between 54 and 56 kg years and a range between 31 and 49 kg as suitable to prevent AD in adults aged 50–64 and ≥ 65 years, respectively. Routine assessment of hand grip strength can help healthcare professionals identify people at increased risk of AD. Strength-based interventions could provide a practical strategy to support cognitive health and reduce the risk of dementia in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Plasma p-tau181 With Age, Adjusted for Kidney Function and Sociodemographic Factors","authors":"Jemma Hazan,&nbsp;Kathy Y. Liu,&nbsp;Henrik Zetterberg,&nbsp;Nick Fox,&nbsp;Robert Howard,&nbsp;with ADNI","doi":"10.1002/gps.70138","DOIUrl":"https://doi.org/10.1002/gps.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Plasma phosphorylated tau (p-tau) levels, such as p-tau181, are elevated in Alzheimer's disease compared to cognitively unimpaired individuals. They represent potential candidate blood biomarkers for use in memory services where CSF examinations are not available. However, the effect of age on plasma p-tau levels remains undetermined. Limited studies have investigated the association between age and plasma p-tau thus far, and fewer still have differentiated levels by brain amyloid pathology. Characterising these associations and determining if this is influenced by sociodemographic factors or medical comorbidities is important for establishing blood biomarker reference ranges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using ADNI data, we analysed 860 observations (581 participants; age range: 55–95 years; 56.0% male; 93.6% White). Linear mixed models (LMMs) estimated fixed effects of age, creatinine, baseline BMI, sex, ethnicity, and group (Control vs. AD) on plasma p-tau181 concentration, with a random intercept for participant ID. Separate LMMs assessed covariate effects and interactions with group status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis of ADNI data revealed a significant positive association between p-tau181 levels, group status, and creatinine in the fully adjusted LLM. Group status may have obscured the total effect of age on p-tau181, as its removal from the model resulted in a significant age effect. Single-variable models showed the positive association between either age, or creatinine and p-tau181 levels did not differ between control and AD groups. There was a significant negative association between BMI and plasma p-tau, which was stronger in AD versus control groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides insights into the factors that may influence plasma p-tau181 levels. These findings underscore the need to account for clinical and demographic factors when interpreting p-tau181. Future research should validate these associations in diverse populations and explore underlying mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}