Suicide among older adults living in care homes is a major public health challenge. This study analyses the perceptions and attitudes of professionals working in care homes towards suicidal ideation and suicide attempts in this population.
Method
A total of 338 nursing home professionals from Spain participated in the study. A vignette-based methodology was used, in which cases of suicidal ideation or suicide attempts were described, varying the gender of the actor. Responses to a questionnaire assessed perceived frequency, attention-seeking behaviour, ageism, experienced anxiety, perceived risk and likelihood of future suicide.
Results
Professionals perceived suicidal ideation to be more common and normative in older adults, particularly women. However, they attributed a higher risk and likelihood of suicide to cases involving suicide attempts, which also elicited more anxiety. No significant differences were found in the perception of these situations as ‘attention-seeking behaviour'.
Discussion
Acceptance of suicidal ideation as normal behaviour of suicidal ideation in older adults may reduce the perceived urgency to intervene, highlighting the need for specialised training to help identify risk signals and act promptly. This study highlights the importance of addressing age and gender bias in suicide prevention in care homes and advocates the development of evidence-based strategies.
{"title":"Analysis of Professionals' Perceptions of Suicide in Older Adults Living in Care Homes","authors":"Rita Redondo, Carolina Pinazo-Clapés, Irene Checa, Sacramento Pinazo-Hernandis, Alicia Sales","doi":"10.1002/gps.70152","DOIUrl":"https://doi.org/10.1002/gps.70152","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Suicide among older adults living in care homes is a major public health challenge. This study analyses the perceptions and attitudes of professionals working in care homes towards suicidal ideation and suicide attempts in this population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 338 nursing home professionals from Spain participated in the study. A vignette-based methodology was used, in which cases of suicidal ideation or suicide attempts were described, varying the gender of the actor. Responses to a questionnaire assessed perceived frequency, attention-seeking behaviour, ageism, experienced anxiety, perceived risk and likelihood of future suicide.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Professionals perceived suicidal ideation to be more common and normative in older adults, particularly women. However, they attributed a higher risk and likelihood of suicide to cases involving suicide attempts, which also elicited more anxiety. No significant differences were found in the perception of these situations as ‘attention-seeking behaviour'.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Acceptance of suicidal ideation as normal behaviour of suicidal ideation in older adults may reduce the perceived urgency to intervene, highlighting the need for specialised training to help identify risk signals and act promptly. This study highlights the importance of addressing age and gender bias in suicide prevention in care homes and advocates the development of evidence-based strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pareidolic illusions involve perceiving meaningful objects in ambiguous or visually complex stimuli. Although seen in dementia, their presence and associated neuroanatomical basis in older adults without dementia remain unclear. Investigating these illusions in this population may reveal early neurodegenerative changes preceding overt dementia. Such insights could support the use of pareidolic illusions as potential early markers for diagnosis and intervention. This study therefore aimed to examine the prevalence and associated neuroanatomical characteristics of pareidolic illusions in community-dwelling older adults without dementia, as assessed by the Noise Pareidolia Test (NPT).
Methods
We investigated the prevalence of pareidolic illusions in older adults aged 65–84 residing in Tokyo, Japan with suspected cognitive decline but without dementia. Participants were classified as cognitively normal or having mild cognitive impairment (MCI) based on standard criteria. Participants underwent NPT, and those who exhibited one or more pareidolic illusions were classified as pareidolia-positive. Additionally, a whole-brain voxel-based morphometry (VBM) of structural magnetic resonance imaging data was performed to assess gray matter volume differences associated with pareidolic illusions.
Results
Pareidolic illusions were present in 35.1% (155/441) of participants. These individuals were significantly older, had shorter years of education, and more likely to be diagnosed with MCI. VBM revealed significantly lower gray matter volume in bilateral temporal clusters—areas associated with face-related visuoperceptual processing—among pareidolia-positive individuals.
Conclusions
Pareidolic illusions were relatively common in community-dwelling older adults without dementia. These illusions may be an early marker of neurodegenerative changes affecting visuoperceptual pathways, and may be detectable using NPT.
{"title":"Pareidolic Illusions and Associated Lower Regional Gray Matter Volumes in Community-Dwelling Older Adults Without Dementia: The Arakawa 65+ Study","authors":"Hana Nishida, Shogyoku Bun, Ryo Shikimoto, Hisashi Kida, Kouta Suzuki, Akihiro Takamiya, Jinichi Hirano, Hidehito Niimura, Hiroyuki Uchida, Masaru Mimura","doi":"10.1002/gps.70151","DOIUrl":"https://doi.org/10.1002/gps.70151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Pareidolic illusions involve perceiving meaningful objects in ambiguous or visually complex stimuli. Although seen in dementia, their presence and associated neuroanatomical basis in older adults without dementia remain unclear. Investigating these illusions in this population may reveal early neurodegenerative changes preceding overt dementia. Such insights could support the use of pareidolic illusions as potential early markers for diagnosis and intervention. This study therefore aimed to examine the prevalence and associated neuroanatomical characteristics of pareidolic illusions in community-dwelling older adults without dementia, as assessed by the Noise Pareidolia Test (NPT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We investigated the prevalence of pareidolic illusions in older adults aged 65–84 residing in Tokyo, Japan with suspected cognitive decline but without dementia. Participants were classified as cognitively normal or having mild cognitive impairment (MCI) based on standard criteria. Participants underwent NPT, and those who exhibited one or more pareidolic illusions were classified as pareidolia-positive. Additionally, a whole-brain voxel-based morphometry (VBM) of structural magnetic resonance imaging data was performed to assess gray matter volume differences associated with pareidolic illusions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pareidolic illusions were present in 35.1% (155/441) of participants. These individuals were significantly older, had shorter years of education, and more likely to be diagnosed with MCI. VBM revealed significantly lower gray matter volume in bilateral temporal clusters—areas associated with face-related visuoperceptual processing—among pareidolia-positive individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Pareidolic illusions were relatively common in community-dwelling older adults without dementia. These illusions may be an early marker of neurodegenerative changes affecting visuoperceptual pathways, and may be detectable using NPT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The association between core clinical features and anxiety and the neural basis of anxiety in patients with dementia with Lewy bodies (DLB) are unknown. Therefore, this study examined the core clinical features associated with anxiety in DLB and identified the brain regions associated with anxiety using statistical imaging analysis.
Methods
This study was conducted using a part of the data from “The Japan multicenter study: Behavioral and psychological symptoms Integrated Research in Dementia-Retrospective Neuroimaging part”. Overall, 40 patients with probable DLB whose clinical dementia rating score was either 0.5 or 1 were included in this study. Anxiety was evaluated using the Neuropsychiatric Inventory (NPI). The incidence of each of the 4 core features was compared between patients with and without anxiety, and the brain regions associated with anxiety were examined using single-photon emission computed tomography data.
Results
Patients with DLB with anxiety had a significantly higher percentage of fluctuating cognition than those without anxiety. The NPI anxiety score was significantly negatively correlated with regional cerebral blood flow in the right supramarginal gyrus in patients with DLB.
Conclusion
Anxiety in DLB is associated with fluctuating cognition. It is also likely that the brain regions associated with anxiety in DLB are potentially influenced by the neurofunctional characteristics of DLB, in which the parietal lobes are more likely to be impaired.
{"title":"Neural Basis of Anxiety in Dementia With Lewy Bodies","authors":"Naohiro Kimura, Yoshihiro Chadani, Ryo Kawai, Ryoko Fujito, Hideki Kanemoto, Ryuichi Takahashi, Tetsuo Kashibayashi, Shunichiro Shinagawa, Kenji Tagai, Kazunari Ishii, Manabu Ikeda, Hiroaki Kazui","doi":"10.1002/gps.70150","DOIUrl":"https://doi.org/10.1002/gps.70150","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The association between core clinical features and anxiety and the neural basis of anxiety in patients with dementia with Lewy bodies (DLB) are unknown. Therefore, this study examined the core clinical features associated with anxiety in DLB and identified the brain regions associated with anxiety using statistical imaging analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was conducted using a part of the data from “The Japan multicenter study: Behavioral and psychological symptoms Integrated Research in Dementia-Retrospective Neuroimaging part”. Overall, 40 patients with probable DLB whose clinical dementia rating score was either 0.5 or 1 were included in this study. Anxiety was evaluated using the Neuropsychiatric Inventory (NPI). The incidence of each of the 4 core features was compared between patients with and without anxiety, and the brain regions associated with anxiety were examined using single-photon emission computed tomography data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with DLB with anxiety had a significantly higher percentage of fluctuating cognition than those without anxiety. The NPI anxiety score was significantly negatively correlated with regional cerebral blood flow in the right supramarginal gyrus in patients with DLB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Anxiety in DLB is associated with fluctuating cognition. It is also likely that the brain regions associated with anxiety in DLB are potentially influenced by the neurofunctional characteristics of DLB, in which the parietal lobes are more likely to be impaired.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brendan Flanagan, Jayne Lynch, Sahil Kakar, Bernadette McGuinness, Katherine Patterson, A. Peter Passmore, Emma Louise Cunningham
{"title":"Most Patients Attending a Geriatrician-Led Memory Clinic are Not Eligible for Alzheimer's Disease-Modifying Drugs","authors":"Brendan Flanagan, Jayne Lynch, Sahil Kakar, Bernadette McGuinness, Katherine Patterson, A. Peter Passmore, Emma Louise Cunningham","doi":"10.1002/gps.70149","DOIUrl":"https://doi.org/10.1002/gps.70149","url":null,"abstract":"","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The relationship between sleep duration and depressive symptoms remains controversial in middle-aged and older adults. The aim of this study is to investigate the relationship of sleep duration trajectories with depressive symptoms and conduct further exploration through network analysis.
Methods
Based on the five waves of data on 8681 middle-aged and older adults from 2011 to 2020 in the China Health and Retirement Longitudinal Study database, group-based trajectory modeling was employed to depict their sleep trajectories. Binary logistic regression and network analysis were conducted to assess the relationship between sleep trajectories and depressive symptoms. Subgroup analysis was performed based on age (< 60, ≥ 60 years).
Results
The study identified three nighttime sleep duration trajectories, three daytime nap duration trajectories, and nine combined trajectories. People with initially low or moderate then decreasing nighttime sleep duration trajectory were more likely to have depressive symptoms compared with those with persistently recommended trajectory. And people with the combination of initially low then decreasing nighttime sleep and initially moderate or low then increasing daytime nap duration trajectories and the combination of initially moderate then decreasing nighttime sleep and initially high then increasing daytime nap duration trajectories were prone to have depressive symptoms compared with the combination of persistently recommended nighttime sleep and initially moderate then increasing daytime nap duration trajectories. The association between sleep trajectories and depressive symptoms may be modified by age groups (< 60 vs. ≥ 60 years). In network analyses, “felt depressed” was the most central item, and there were structural differences across different sleep duration trajectory networks.
Conclusions
Taking naps could offset the risk of depressive symptoms for people who lacked sleep at night. Developing different intervention strategies based on different sleep trajectories might help alleviate the onset of depressive symptoms.
{"title":"Associations Between Sleep Duration Trajectories and Depressive Symptoms Among Middle-Aged and Older Adults: Findings From a Nationally Representative Survey","authors":"Tingyi Jia, Changgui Kou, Yanchi Zhang, Zhouyang Sun, Qianlu Ding, Yuan Feng, Xinru Guo, Songyu Wu, Qianyi Wang, Qianlong Huang, Xiaopeng Sun, Wei Han, Wei Bai","doi":"10.1002/gps.70154","DOIUrl":"https://doi.org/10.1002/gps.70154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The relationship between sleep duration and depressive symptoms remains controversial in middle-aged and older adults. The aim of this study is to investigate the relationship of sleep duration trajectories with depressive symptoms and conduct further exploration through network analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on the five waves of data on 8681 middle-aged and older adults from 2011 to 2020 in the China Health and Retirement Longitudinal Study database, group-based trajectory modeling was employed to depict their sleep trajectories. Binary logistic regression and network analysis were conducted to assess the relationship between sleep trajectories and depressive symptoms. Subgroup analysis was performed based on age (< 60, ≥ 60 years).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study identified three nighttime sleep duration trajectories, three daytime nap duration trajectories, and nine combined trajectories. People with initially low or moderate then decreasing nighttime sleep duration trajectory were more likely to have depressive symptoms compared with those with persistently recommended trajectory. And people with the combination of initially low then decreasing nighttime sleep and initially moderate or low then increasing daytime nap duration trajectories and the combination of initially moderate then decreasing nighttime sleep and initially high then increasing daytime nap duration trajectories were prone to have depressive symptoms compared with the combination of persistently recommended nighttime sleep and initially moderate then increasing daytime nap duration trajectories. The association between sleep trajectories and depressive symptoms may be modified by age groups (< 60 vs. ≥ 60 years). In network analyses, “felt depressed” was the most central item, and there were structural differences across different sleep duration trajectory networks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Taking naps could offset the risk of depressive symptoms for people who lacked sleep at night. Developing different intervention strategies based on different sleep trajectories might help alleviate the onset of depressive symptoms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lack of formal schooling remains prevalent among older adults in China, particularly in rural areas. This study investigates the cognitive function trajectory and influencing factors in older adults without formal schooling from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).
Methods
The study included 2159 individuals without formal schooling (NFS) and 2234 individuals with formal schooling (FS), all cognitively healthy and aged over 60 at the first observation from the 2008 - 2018 CLHLS cohort. Cognitive function was measured using the Chinese version of the Mini-Mental State Examination (MMSE). Group-based trajectory modeling was used to identify potential heterogeneity of longitudinal changes over the 10 years. Logistic regression was used to investigate associations between baseline characteristics (age, sex, marital status, functional abilities, leisure activity, and health status and behaviors) and trajectory classes.
Results
NFS individuals were generally older (80 vs. 75.3 years), more likely to be female (72.2% vs. 29.9%), unmarried (43.1% vs. 68.2%), and underweight (27.3% vs. 17.8%). They also had higher prevalence of hearing impairment (40.1% vs. 30.5%), functional limitations (39.6% vs. 19.2%), and extreme sleep length, while lower baseline cognitive function (MMSE score: 26.5 vs. 28.2). Additionally, they were less likely to engage in exercise, leisure activities, or alcohol consumption. Three trajectories (labeled stable, slow decline, and rapid decline) were identified according to the changes in MMSE scores for both groups. For the NFS group, both the slow and rapid decline groups accounted for a larger proportion (15.0% and 12.3%, respectively) than the FS decline groups (6.5% and 5.3%, respectively), and the NFS individuals had a lower baseline MMSE score with a faster decline. In the multivariable logistic regression analyses, older age, hearing impairment, poorer functional abilities, and lower baseline MMSE scores were significantly associated with cognitive decline in both groups compared to the stable group. For the NFS individuals, female sex was a risk factor for slow decline, while marital status was associated with rapid decline.
Conclusions
These findings underscore the importance of considering formal schooling status in cognitive aging research. They also emphasize the need to address educational disparities and promote social and economic well-being, particularly for vulnerable populations, to mitigate the risk of cognitive decline and
在中国，特别是在农村地区，老年人缺乏正规教育的现象仍然普遍存在。本研究通过中国健康寿命纵向调查（CLHLS）对未接受正规教育的老年人的认知功能轨迹及其影响因素进行了研究。方法纳入2008 - 2018年CLHLS队列中首次观察时认知健康且年龄在60岁以上的2159名未受过正规教育的个体（NFS）和2234名受过正规教育的个体（FS）。认知功能采用中文版的简易精神状态测验（MMSE）进行测量。使用基于组的轨迹模型来识别10年来纵向变化的潜在异质性。采用Logistic回归调查基线特征（年龄、性别、婚姻状况、功能能力、休闲活动、健康状况和行为）与轨迹类别之间的关系。结果NFS患者普遍年龄较大（80岁vs. 75.3岁），女性居多（72.2% vs. 29.9%），未婚（43.1% vs. 68.2%），体重过轻（27.3% vs. 17.8%）。他们也有更高的听力障碍患病率（40.1%对30.5%），功能限制（39.6%对19.2%）和极端睡眠时间，而较低的基线认知功能（MMSE评分：26.5对28.2）。此外，他们不太可能从事运动、休闲活动或饮酒。根据两组MMSE评分的变化，确定了三种轨迹（标记为稳定、缓慢下降和快速下降）。对于NFS组，缓慢和快速下降组所占的比例（分别为15.0%和12.3%）都大于FS下降组（分别为6.5%和5.3%），并且NFS个体的基线MMSE评分较低，下降速度较快。在多变量logistic回归分析中，与稳定组相比，年龄较大、听力障碍、较差的功能能力和较低的基线MMSE评分与两组的认知能力下降显著相关。对于NFS个体，女性性别是缓慢下降的危险因素，而婚姻状况与快速下降有关。结论这些发现强调了在认知衰老研究中考虑正规教育的重要性。他们还强调需要解决教育差距问题，促进社会和经济福祉，特别是弱势群体的福祉，以减轻认知能力下降和痴呆症的风险。
{"title":"Ten-Year Cognitive Trajectories and Determinants in Chinese Older Adults Without Formal Schooling: Chinese Longitudinal Healthy Longevity Survey 2008–2018","authors":"Lihui Tu, Xiaozhen Lv, Qinge Zhang","doi":"10.1002/gps.70135","DOIUrl":"https://doi.org/10.1002/gps.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Lack of formal schooling remains prevalent among older adults in China, particularly in rural areas. This study investigates the cognitive function trajectory and influencing factors in older adults without formal schooling from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 2159 individuals without formal schooling (NFS) and 2234 individuals with formal schooling (FS), all cognitively healthy and aged over 60 at the first observation from the 2008 - 2018 CLHLS cohort. Cognitive function was measured using the Chinese version of the Mini-Mental State Examination (MMSE). Group-based trajectory modeling was used to identify potential heterogeneity of longitudinal changes over the 10 years. Logistic regression was used to investigate associations between baseline characteristics (age, sex, marital status, functional abilities, leisure activity, and health status and behaviors) and trajectory classes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NFS individuals were generally older (80 vs. 75.3 years), more likely to be female (72.2% vs. 29.9%), unmarried (43.1% vs. 68.2%), and underweight (27.3% vs. 17.8%). They also had higher prevalence of hearing impairment (40.1% vs. 30.5%), functional limitations (39.6% vs. 19.2%), and extreme sleep length, while lower baseline cognitive function (MMSE score: 26.5 vs. 28.2). Additionally, they were less likely to engage in exercise, leisure activities, or alcohol consumption. Three trajectories (labeled stable, slow decline, and rapid decline) were identified according to the changes in MMSE scores for both groups. For the NFS group, both the slow and rapid decline groups accounted for a larger proportion (15.0% and 12.3%, respectively) than the FS decline groups (6.5% and 5.3%, respectively), and the NFS individuals had a lower baseline MMSE score with a faster decline. In the multivariable logistic regression analyses, older age, hearing impairment, poorer functional abilities, and lower baseline MMSE scores were significantly associated with cognitive decline in both groups compared to the stable group. For the NFS individuals, female sex was a risk factor for slow decline, while marital status was associated with rapid decline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings underscore the importance of considering formal schooling status in cognitive aging research. They also emphasize the need to address educational disparities and promote social and economic well-being, particularly for vulnerable populations, to mitigate the risk of cognitive decline and ","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the Barthel Index (BI) score in predicting the 1-month and 1-year prognosis after discharge.
Methods
This was a retrospective observational single-center study. We retrospectively enrolled consecutive inpatients aged ≥ 75 years from a large public hospital. Information of the basic demographic variables, BI score, disease burden, length of hospital stay, medical cost and outcomes of patients were collected. Then we analyzed the association between BI score and clinical outcomes.
Results
A total of 242 subjects were included in this study. The median of BI score was 40 (5, 70). There were 48.76% and 82.23% patients with poor prognosis within 1 month and 1 year after discharge. BI remained an independent predictor of poor outcome within 1 month (P < 0.001) and 1 year (P = 0.027) after adjusting other factors. BI score was negatively correlated with poor outcomes. The calibration of 1-year outcomes was better than that of 1-month outcomes. The ROC analysis showed the AUC of the BI in predicting 1-month and 1-year outcomes were 0.860(P < 0.001) and 0.674(P < 0.001) respectively. The cutoff values for BI to predict 1-month and 1-year outcomes were 42.5 and 52.5.
Conclusions
The BI score at admission was an useful predictor of outcomes within 1 month and 1 year after discharge for very elderly multimorbidity inpatients.
{"title":"Barthel Index Score at Admission to Predict 1-Month and 1-Year Prognosis in Inpatients Aged ≥ 75 Years With Multimorbidity","authors":"Xin Chen, Chen-lu Zhang, Hua Jiang","doi":"10.1002/gps.70147","DOIUrl":"https://doi.org/10.1002/gps.70147","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the Barthel Index (BI) score in predicting the 1-month and 1-year prognosis after discharge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a retrospective observational single-center study. We retrospectively enrolled consecutive inpatients aged ≥ 75 years from a large public hospital. Information of the basic demographic variables, BI score, disease burden, length of hospital stay, medical cost and outcomes of patients were collected. Then we analyzed the association between BI score and clinical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 242 subjects were included in this study. The median of BI score was 40 (5, 70). There were 48.76% and 82.23% patients with poor prognosis within 1 month and 1 year after discharge. BI remained an independent predictor of poor outcome within 1 month (<i>P</i> < 0.001) and 1 year (<i>P</i> = 0.027) after adjusting other factors. BI score was negatively correlated with poor outcomes. The calibration of 1-year outcomes was better than that of 1-month outcomes. The ROC analysis showed the AUC of the BI in predicting 1-month and 1-year outcomes were 0.860(<i>P</i> < 0.001) and 0.674(<i>P</i> < 0.001) respectively. The cutoff values for BI to predict 1-month and 1-year outcomes were 42.5 and 52.5.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The BI score at admission was an useful predictor of outcomes within 1 month and 1 year after discharge for very elderly multimorbidity inpatients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. A. McDicken, E. Elliott, G. Blayney, S. Makin, M. Ali, A. J. Larner, T. J. Quinn, VISTA-Cognition Collaborators. “Accuracy of the Short-Form Montreal Cognitive Assessment: Systematic Review and Validation,” International Journal of Geriatric Psychiatry 34, no. 10 (October 2019): 1515–1525, https://doi.org/10.1002/gps.5162.
There are no changes required to the conclusions. We apologize for this error.
Updated Figure 2
J. A. McDicken， E. Elliott， G. Blayney， S. Makin， M. Ali， A. J. Larner， T. J. Quinn， vista -认知合作者。“短格式蒙特利尔认知评估的准确性：系统回顾和验证”，《国际老年精神病学杂志》34期，第2期。10（2019年10月）：1515-1525,https://doi.org/10.1002/gps.5162.There结论无需更改。我们为这个错误道歉。更新后的图2
{"title":"Correction to “Accuracy of the Short-Form Montreal Cognitive Assessment: Systematic Review and Validation”","authors":"","doi":"10.1002/gps.70146","DOIUrl":"https://doi.org/10.1002/gps.70146","url":null,"abstract":"<p>J. A. McDicken, E. Elliott, G. Blayney, S. Makin, M. Ali, A. J. Larner, T. J. Quinn, VISTA-Cognition Collaborators. “Accuracy of the Short-Form Montreal Cognitive Assessment: Systematic Review and Validation,” <i>International Journal of Geriatric Psychiatry</i> 34, no. 10 (October 2019): 1515–1525, https://doi.org/10.1002/gps.5162.</p><p>There are no changes required to the conclusions. We apologize for this error.</p><p>Updated Figure 2\u0000 </p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia R. Bacci, Marc D. Rudolph, Suzanne Craft, James R. Bateman, Samuel N. Lockhart, Michelle M. Mielke
Objectives
In a sample of community-dwelling older adults, we examined the association of Alzheimer's Disease and Related Dementias (AD/ADRD) blood-based biomarkers (BBMs) and neuropsychiatric symptoms (NPS) and whether informant type (i.e., spouse vs. child vs. other) modified that association.
Methods
This study included 430 participants with a cognitively unimpaired or mild cognitive impairment consensus diagnosis from the Wake Forest Alzheimer's Disease Research Center Clinical Core cohort. Informants reported NPS using the Neuropsychiatric Inventory Questionnaire. AD/ADRD BBMs included the Aβ42/40 ratio, p-tau181, p-tau217, NfL, and GFAP. Generalized linear models were used to examine the associations between AD/ADRD BBMs and NPS. Secondary models adjusted for age, sex, education, race, and cognitive status. Tertiary models adjusted for covariates in secondary models, as well as informant type. Interactions between informant type and AD/ADRD BBMs were examined.
Results
Higher p-tau217 was associated with higher NPS in both unadjusted models and models adjusted for demographics and cognitive status. This association was attenuated and no longer statistically significant after additionally adjusting for informant type. Significant interactions of informant type and p-tau181 or p-tau217 on NPS were demonstrated, where p-tau181 or p-tau217 were more strongly associated with NPS reported by children compared to spouses.
Conclusions
Informant type modified the association between AD/ADRD BBMs and NPS, with stronger associations observed when symptoms were reported by child informants compared to spouse informants. These findings have important implications for earlier detection of individuals with AD/ADRD pathologies.
{"title":"The Relationship of Alzheimer's Disease and Related Dementias Blood-Based Biomarkers and Informant-Reported Neuropsychiatric Symptoms Differs by Informant Type in Older Adults Without Dementia","authors":"Julia R. Bacci, Marc D. Rudolph, Suzanne Craft, James R. Bateman, Samuel N. Lockhart, Michelle M. Mielke","doi":"10.1002/gps.70140","DOIUrl":"https://doi.org/10.1002/gps.70140","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In a sample of community-dwelling older adults, we examined the association of Alzheimer's Disease and Related Dementias (AD/ADRD) blood-based biomarkers (BBMs) and neuropsychiatric symptoms (NPS) and whether informant type (i.e., spouse vs. child vs. other) modified that association.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 430 participants with a cognitively unimpaired or mild cognitive impairment consensus diagnosis from the Wake Forest Alzheimer's Disease Research Center Clinical Core cohort. Informants reported NPS using the Neuropsychiatric Inventory Questionnaire. AD/ADRD BBMs included the Aβ42/40 ratio, p-tau181, p-tau217, NfL, and GFAP. Generalized linear models were used to examine the associations between AD/ADRD BBMs and NPS. Secondary models adjusted for age, sex, education, race, and cognitive status. Tertiary models adjusted for covariates in secondary models, as well as informant type. Interactions between informant type and AD/ADRD BBMs were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher p-tau217 was associated with higher NPS in both unadjusted models and models adjusted for demographics and cognitive status. This association was attenuated and no longer statistically significant after additionally adjusting for informant type. Significant interactions of informant type and p-tau181 or p-tau217 on NPS were demonstrated, where p-tau181 or p-tau217 were more strongly associated with NPS reported by children compared to spouses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Informant type modified the association between AD/ADRD BBMs and NPS, with stronger associations observed when symptoms were reported by child informants compared to spouse informants. These findings have important implications for earlier detection of individuals with AD/ADRD pathologies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurodegenerative Disorders: Advances in Neurobiology and New Treatment Perspectives","authors":"Yaohua Chen","doi":"10.1002/gps.70145","DOIUrl":"https://doi.org/10.1002/gps.70145","url":null,"abstract":"","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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