Julia R. Bacci, Marc D. Rudolph, Suzanne Craft, James R. Bateman, Samuel N. Lockhart, Michelle M. Mielke
Objectives
In a sample of community-dwelling older adults, we examined the association of Alzheimer's Disease and Related Dementias (AD/ADRD) blood-based biomarkers (BBMs) and neuropsychiatric symptoms (NPS) and whether informant type (i.e., spouse vs. child vs. other) modified that association.
Methods
This study included 430 participants with a cognitively unimpaired or mild cognitive impairment consensus diagnosis from the Wake Forest Alzheimer's Disease Research Center Clinical Core cohort. Informants reported NPS using the Neuropsychiatric Inventory Questionnaire. AD/ADRD BBMs included the Aβ42/40 ratio, p-tau181, p-tau217, NfL, and GFAP. Generalized linear models were used to examine the associations between AD/ADRD BBMs and NPS. Secondary models adjusted for age, sex, education, race, and cognitive status. Tertiary models adjusted for covariates in secondary models, as well as informant type. Interactions between informant type and AD/ADRD BBMs were examined.
Results
Higher p-tau217 was associated with higher NPS in both unadjusted models and models adjusted for demographics and cognitive status. This association was attenuated and no longer statistically significant after additionally adjusting for informant type. Significant interactions of informant type and p-tau181 or p-tau217 on NPS were demonstrated, where p-tau181 or p-tau217 were more strongly associated with NPS reported by children compared to spouses.
Conclusions
Informant type modified the association between AD/ADRD BBMs and NPS, with stronger associations observed when symptoms were reported by child informants compared to spouse informants. These findings have important implications for earlier detection of individuals with AD/ADRD pathologies.
{"title":"The Relationship of Alzheimer's Disease and Related Dementias Blood-Based Biomarkers and Informant-Reported Neuropsychiatric Symptoms Differs by Informant Type in Older Adults Without Dementia","authors":"Julia R. Bacci, Marc D. Rudolph, Suzanne Craft, James R. Bateman, Samuel N. Lockhart, Michelle M. Mielke","doi":"10.1002/gps.70140","DOIUrl":"https://doi.org/10.1002/gps.70140","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In a sample of community-dwelling older adults, we examined the association of Alzheimer's Disease and Related Dementias (AD/ADRD) blood-based biomarkers (BBMs) and neuropsychiatric symptoms (NPS) and whether informant type (i.e., spouse vs. child vs. other) modified that association.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 430 participants with a cognitively unimpaired or mild cognitive impairment consensus diagnosis from the Wake Forest Alzheimer's Disease Research Center Clinical Core cohort. Informants reported NPS using the Neuropsychiatric Inventory Questionnaire. AD/ADRD BBMs included the Aβ42/40 ratio, p-tau181, p-tau217, NfL, and GFAP. Generalized linear models were used to examine the associations between AD/ADRD BBMs and NPS. Secondary models adjusted for age, sex, education, race, and cognitive status. Tertiary models adjusted for covariates in secondary models, as well as informant type. Interactions between informant type and AD/ADRD BBMs were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher p-tau217 was associated with higher NPS in both unadjusted models and models adjusted for demographics and cognitive status. This association was attenuated and no longer statistically significant after additionally adjusting for informant type. Significant interactions of informant type and p-tau181 or p-tau217 on NPS were demonstrated, where p-tau181 or p-tau217 were more strongly associated with NPS reported by children compared to spouses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Informant type modified the association between AD/ADRD BBMs and NPS, with stronger associations observed when symptoms were reported by child informants compared to spouse informants. These findings have important implications for earlier detection of individuals with AD/ADRD pathologies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurodegenerative Disorders: Advances in Neurobiology and New Treatment Perspectives","authors":"Yaohua Chen","doi":"10.1002/gps.70145","DOIUrl":"https://doi.org/10.1002/gps.70145","url":null,"abstract":"","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite the recognized heterogeneity of cognitive function in older adults and its propensity for transition, this phenomenon remains inadequately understood among older adults with cardiovascular metabolic diseases (CMD). We aimed to explore the latent profiles of cognitive function among older adults with CMD, along with the transition probabilities between profiles and associated predictors.
Methods
A cohort study including 2304 older adults with CMD was drawn from the Chinese Longitudinal Healthy Longevity Survey. Cognitive function assessments and covariate data were gathered in 2011, with cognitive function reassessed in 2014. Latent profile analysis was employed to explore the latent profiles of cognitive function at two time points, latent transition analysis to examine transition probabilities between profiles, and multinomial logistic regression to investigate predictive factors of profile transitions.
Results
Latent profile analysis supported 3-profile model: normal cognitive function, mild cognitive impairment, and severe cognitive impairment. Over the 3-year period, the normal cognitive function profile exhibited greater stability, with probabilities of 0.834, while the mild cognitive impairment profile demonstrated a higher likelihood of transitioning to the normal cognitive function profile, with a probability of 0.630. Age, sleep duration, and social participation emerged as predictive factors of profile transitions.
Conclusions
Significant heterogeneity exists in cognitive function among older adults with CMD, characterized by three distinct profiles. Varied transition patterns and probabilities underscore the importance of identifying and intervening with individuals at elevated risk of negative transitions, potentially improving their cognitive function.
{"title":"Latent Transition and Predictors of Cognitive Function Among Community-Dwelling Chinese Older Adults With Cardiovascular Metabolic Diseases","authors":"Yaqi Wang, Bowen Wan, Xueying Xu, Qingyun Lv, Yuan He, Jingwen Liu, Hairong Chang, Yue Zhao, Li Fu, Xiaoying Zang, Xiaonan Zhang","doi":"10.1002/gps.70144","DOIUrl":"https://doi.org/10.1002/gps.70144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Despite the recognized heterogeneity of cognitive function in older adults and its propensity for transition, this phenomenon remains inadequately understood among older adults with cardiovascular metabolic diseases (CMD). We aimed to explore the latent profiles of cognitive function among older adults with CMD, along with the transition probabilities between profiles and associated predictors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cohort study including 2304 older adults with CMD was drawn from the Chinese Longitudinal Healthy Longevity Survey. Cognitive function assessments and covariate data were gathered in 2011, with cognitive function reassessed in 2014. Latent profile analysis was employed to explore the latent profiles of cognitive function at two time points, latent transition analysis to examine transition probabilities between profiles, and multinomial logistic regression to investigate predictive factors of profile transitions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Latent profile analysis supported 3-profile model: normal cognitive function, mild cognitive impairment, and severe cognitive impairment. Over the 3-year period, the normal cognitive function profile exhibited greater stability, with probabilities of 0.834, while the mild cognitive impairment profile demonstrated a higher likelihood of transitioning to the normal cognitive function profile, with a probability of 0.630. Age, sleep duration, and social participation emerged as predictive factors of profile transitions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Significant heterogeneity exists in cognitive function among older adults with CMD, characterized by three distinct profiles. Varied transition patterns and probabilities underscore the importance of identifying and intervening with individuals at elevated risk of negative transitions, potentially improving their cognitive function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bingxin Ma, Yan Sun, Qingxian Shen, Yuyang Zhang, Dongrui Wang, Junwei Ma, Xinyi Dong, Yue Zhao, Qi Lu
Objectives
Cognitive impairment and sensory impairment are highly prevalent in older adults, but the relationship between the two remains inconclusive. This study aimed to investigate the relationship between visual impairment (VI), hearing impairment (HI), dual sensory impairment (DSI), and the onset of cognitive impairment among Chinese older adults.
Methods
Data were obtained from the 2011–2018 China Longitudinal Healthy Longevity Survey (CLHLS) cohort. Cognitive impairment was defined using the Chinese version of the Mini-Mental State Examination (CMMSE), with a score below 18 indicating its onset. VI and HI were identified through self-reported questionnaires. Cox proportional hazard regression models were applied to estimate crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the associations between single and dual SI with cognitive impairment.
Results
A total of 3239 adults aged 65 and older were analyzed, with 329 participants (10.2%) developing cognitive impairment over 21,039 person-years of follow-up. Participants with single VI (HR 1.42, 95% CI 1.08–1.87), single HI (HR 2.24, 95% CI 1.58–3.15), and DSI (HR 2.08, 95% CI 1.44–3.01) exhibited significantly higher risks of cognitive impairment compared to those without SI.
Conclusions
In this nationally representative sample of Chinese older adults, VI, HI, and DSI, were significantly associated with an increased risk of cognitive impairment. Future studies are encouraged to employ standardized tools to assess sensory and cognitive impairments, further explore the mechanisms linking the two, and consider the potential benefits of incorporating sensory impairment assessment and management into primary healthcare to reduce the risk of cognitive impairment.
目的认知障碍和感觉障碍在老年人中非常普遍，但两者之间的关系尚不明确。本研究旨在探讨中国老年人视觉障碍（VI）、听力障碍（HI）、双重感觉障碍（DSI）与认知障碍发病的关系。方法数据来自2011-2018年中国纵向健康寿命调查（CLHLS）队列。认知障碍的定义采用中文版的简易精神状态检查（CMMSE），分数低于18分表明其发病。通过自我报告问卷来确定VI和HI。采用Cox比例风险回归模型估计单双SI与认知障碍之间的粗风险比（hr）和校正风险比（hr）， 95%置信区间（ci）。结果共分析了3239名65岁及以上的成年人，其中329名参与者（10.2%）在21039人-年的随访中出现认知障碍。单一VI （HR 1.42, 95% CI 1.08-1.87）、单一HI （HR 2.24, 95% CI 1.58-3.15）和DSI （HR 2.08, 95% CI 1.44-3.01）的参与者与没有SI的参与者相比，表现出显著更高的认知障碍风险。结论：在这个具有全国代表性的中国老年人样本中，VI、HI和DSI与认知障碍风险增加显著相关。未来的研究鼓励采用标准化的工具来评估感觉和认知障碍，进一步探索两者之间的联系机制，并考虑将感觉障碍评估和管理纳入初级卫生保健以降低认知障碍风险的潜在益处。
{"title":"The Association Between Sensory Impairment and Cognitive Impairment Among Older Adults: Insights From a National Cohort Study in China","authors":"Bingxin Ma, Yan Sun, Qingxian Shen, Yuyang Zhang, Dongrui Wang, Junwei Ma, Xinyi Dong, Yue Zhao, Qi Lu","doi":"10.1002/gps.70139","DOIUrl":"https://doi.org/10.1002/gps.70139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Cognitive impairment and sensory impairment are highly prevalent in older adults, but the relationship between the two remains inconclusive. This study aimed to investigate the relationship between visual impairment (VI), hearing impairment (HI), dual sensory impairment (DSI), and the onset of cognitive impairment among Chinese older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were obtained from the 2011–2018 China Longitudinal Healthy Longevity Survey (CLHLS) cohort. Cognitive impairment was defined using the Chinese version of the Mini-Mental State Examination (CMMSE), with a score below 18 indicating its onset. VI and HI were identified through self-reported questionnaires. Cox proportional hazard regression models were applied to estimate crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the associations between single and dual SI with cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 3239 adults aged 65 and older were analyzed, with 329 participants (10.2%) developing cognitive impairment over 21,039 person-years of follow-up. Participants with single VI (HR 1.42, 95% CI 1.08–1.87), single HI (HR 2.24, 95% CI 1.58–3.15), and DSI (HR 2.08, 95% CI 1.44–3.01) exhibited significantly higher risks of cognitive impairment compared to those without SI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this nationally representative sample of Chinese older adults, VI, HI, and DSI, were significantly associated with an increased risk of cognitive impairment. Future studies are encouraged to employ standardized tools to assess sensory and cognitive impairments, further explore the mechanisms linking the two, and consider the potential benefits of incorporating sensory impairment assessment and management into primary healthcare to reduce the risk of cognitive impairment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tabea Ramin, Jens-Uwe Peter, Michael Schneider, Volker Dahling, Oliver Zolk
Objectives
While the risks of antipsychotics in older adults are well recognized, clinical trials often exclude frail older patients, have short follow-up periods, and provide limited comparative data on specific drugs. This study aimed to explore age-related differences in the adverse effects of six commonly prescribed antipsychotics using a pharmacovigilance database, with additional analysis of sex-based variations.
Methods
We analyzed adverse event (AE) reports associated with aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and haloperidol from the FDA Adverse Event Reporting System (FAERS) database between Q4 2003 and Q2 2024. We utilized Standardized MedDRA Queries (SMQs) and self-defined queries to categorize 18 groups of AEs. Adjusted logistic regression was employed to calculate adjusted reporting odds ratios (aRORs) with 95% confidence intervals (CIs).
Results
Our analysis revealed substance-specific differences in AE profiles. Risperidone had the highest aROR for hyperprolactinemia (aROR 212, 95% CI 203–221), haloperidol for dystonia (aROR 46, 95% CI 41–51), and aripiprazole for akathisia (aROR 45, 95% CI 42–49). Patients aged 65 and older generally demonstrated a higher likelihood of experiencing cardiac, extrapyramidal motor, and sedative AEs compared to those under 65, with few exceptions across the drugs investigated. In contrast, younger patients showed higher odds for metabolic AEs, including dyslipidemia and hyperglycemia (associated with olanzapine and quetiapine), as well as weight gain (with olanzapine, quetiapine, risperidone, and haloperidol). With few exceptions, women generally showed higher reporting odds of adverse events. Sex-related differences were especially pronounced for hyperprolactinemia, with 4.7–8.0 times higher reporting odds in women for aripiprazole, olanzapine, quetiapine, and haloperidol—except for risperidone, where a post-2014 rise in male reports led to higher odds in men. Risperidone was also associated with increased reporting odds of weight gain in men. Additionally, aripiprazole and olanzapine showed 3 to 6 times higher reporting odds for anticholinergic syndrome in men compared to women.
Conclusions
It is essential to consider both age and sex in treatment decisions to optimize the efficacy and tolerability of antipsychotic therapy.
虽然抗精神病药物对老年人的风险已得到充分认识，但临床试验往往排除体弱的老年患者，随访时间短，并且提供的特定药物的比较数据有限。本研究旨在利用药物警戒数据库探索六种常用抗精神病药物不良反应的年龄相关差异，并对基于性别的差异进行额外分析。方法分析2003年第四季度至2024年第二季度FDA不良事件报告系统（FAERS）数据库中与阿立哌唑、氯氮平、奥氮平、喹硫平、利培酮和氟哌啶醇相关的不良事件（AE）报告。我们使用标准化MedDRA查询（SMQs）和自定义查询对18组ae进行了分类。采用校正逻辑回归计算具有95%置信区间（ci）的校正报告优势比（aRORs）。结果我们的分析揭示了声发射谱的物质特异性差异。利培酮治疗高泌乳素血症的aROR最高（aROR 212, 95% CI 203-221），氟哌啶醇治疗肌张力障碍的aROR最高（aROR 46, 95% CI 41-51），阿立哌唑治疗静坐症的aROR最高（aROR 45, 95% CI 42-49）。与65岁以下的患者相比，65岁及以上的患者普遍表现出发生心脏、锥体外系运动和镇静剂ae的可能性更高，在所调查的药物中几乎没有例外。相反，年轻患者出现代谢性不良反应的几率更高，包括血脂异常和高血糖（与奥氮平和喹硫平相关），以及体重增加（与奥氮平、喹硫平、利培酮和氟哌啶醇相关）。除了少数例外，女性通常表现出较高的不良事件报告几率。高泌乳素血症的性别相关差异尤其明显，女性服用阿立哌唑、奥氮平、喹硫平和氟哌啶醇的报告几率是男性的4.7-8.0倍，但利培酮除外，2014年后男性报告的比例上升导致男性的风险更高。利培酮还与男性体重增加的报告几率增加有关。此外，阿立哌唑和奥氮平在男性患抗胆碱能综合征的几率比女性高3 - 6倍。结论在决定治疗方案时应同时考虑年龄和性别因素，以优化抗精神病药物的疗效和耐受性。
{"title":"Age and Sex Differences in Adverse Events Associated With Antipsychotics: An Analysis of the FDA Adverse Events Database","authors":"Tabea Ramin, Jens-Uwe Peter, Michael Schneider, Volker Dahling, Oliver Zolk","doi":"10.1002/gps.70142","DOIUrl":"https://doi.org/10.1002/gps.70142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>While the risks of antipsychotics in older adults are well recognized, clinical trials often exclude frail older patients, have short follow-up periods, and provide limited comparative data on specific drugs. This study aimed to explore age-related differences in the adverse effects of six commonly prescribed antipsychotics using a pharmacovigilance database, with additional analysis of sex-based variations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed adverse event (AE) reports associated with aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and haloperidol from the FDA Adverse Event Reporting System (FAERS) database between Q4 2003 and Q2 2024. We utilized Standardized MedDRA Queries (SMQs) and self-defined queries to categorize 18 groups of AEs. Adjusted logistic regression was employed to calculate adjusted reporting odds ratios (aRORs) with 95% confidence intervals (CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our analysis revealed substance-specific differences in AE profiles. Risperidone had the highest aROR for hyperprolactinemia (aROR 212, 95% CI 203–221), haloperidol for dystonia (aROR 46, 95% CI 41–51), and aripiprazole for akathisia (aROR 45, 95% CI 42–49). Patients aged 65 and older generally demonstrated a higher likelihood of experiencing cardiac, extrapyramidal motor, and sedative AEs compared to those under 65, with few exceptions across the drugs investigated. In contrast, younger patients showed higher odds for metabolic AEs, including dyslipidemia and hyperglycemia (associated with olanzapine and quetiapine), as well as weight gain (with olanzapine, quetiapine, risperidone, and haloperidol). With few exceptions, women generally showed higher reporting odds of adverse events. Sex-related differences were especially pronounced for hyperprolactinemia, with 4.7–8.0 times higher reporting odds in women for aripiprazole, olanzapine, quetiapine, and haloperidol—except for risperidone, where a post-2014 rise in male reports led to higher odds in men. Risperidone was also associated with increased reporting odds of weight gain in men. Additionally, aripiprazole and olanzapine showed 3 to 6 times higher reporting odds for anticholinergic syndrome in men compared to women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>It is essential to consider both age and sex in treatment decisions to optimize the efficacy and tolerability of antipsychotic therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
People's stigma toward dementia may hinder support and care in early dementia. We explored the association of stigma beliefs and attitudes toward dementia with help-seeking intentions among middle-aged and older adults in hypothetical early signs of dementia.
Methods
This cross-sectional study involved individuals aged 40 years and above without dementia, recruited from public facility visitors in Aichi, Japan, between July and August 2024. Dementia stigma was assessed using a short form of the Phillipson Dementia Stigma Assessment, comprising four domains: personal avoidance (avoiding contact and interaction with people with dementia), fear of labeling (fear and anxiety regarding dementia diagnosis), person-centeredness (respect and positive attitudes toward people with dementia), and fear of discrimination (fear of ostracism because of dementia). The participants were asked about their help-seeking intentions from family members, other relatives, healthcare professionals, public facilities, and the phone helpline during the hypothetical early signs of dementia.
Results
Data from 380 individuals were analyzed (mean age 75.0 years; 76.1% women), of whom 90.4% had help-seeking intentions from a partner, 85.9% from children, and 85.8% from healthcare professionals. Multivariable regression analysis revealed that higher dementia stigma was associated with a lower likelihood of help-seeking intentions from a partner, children, and healthcare professionals. Of the subdomains, fear of discrimination was negatively related to help-seeking intentions.
Conclusions
This study indicated that people's stigma beliefs and attitudes may pose barriers to help-seeking in the early stage of dementia. Our findings highlight the need to strengthen support for individuals with early dementia, while reducing people's fear of discrimination and prejudice against dementia in the long term.
{"title":"Stigma Beliefs and Attitudes Against Dementia and Help-Seeking Intentions in Hypothetical Early Signs of Dementia: An Observational Cross-Sectional Study of Middle-Aged and Older Adults in Japan","authors":"Taiji Noguchi, Erhua Shang, Takahiro Hayashi","doi":"10.1002/gps.70141","DOIUrl":"https://doi.org/10.1002/gps.70141","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>People's stigma toward dementia may hinder support and care in early dementia. We explored the association of stigma beliefs and attitudes toward dementia with help-seeking intentions among middle-aged and older adults in hypothetical early signs of dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study involved individuals aged 40 years and above without dementia, recruited from public facility visitors in Aichi, Japan, between July and August 2024. Dementia stigma was assessed using a short form of the Phillipson Dementia Stigma Assessment, comprising four domains: personal avoidance (avoiding contact and interaction with people with dementia), fear of labeling (fear and anxiety regarding dementia diagnosis), person-centeredness (respect and positive attitudes toward people with dementia), and fear of discrimination (fear of ostracism because of dementia). The participants were asked about their help-seeking intentions from family members, other relatives, healthcare professionals, public facilities, and the phone helpline during the hypothetical early signs of dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data from 380 individuals were analyzed (mean age 75.0 years; 76.1% women), of whom 90.4% had help-seeking intentions from a partner, 85.9% from children, and 85.8% from healthcare professionals. Multivariable regression analysis revealed that higher dementia stigma was associated with a lower likelihood of help-seeking intentions from a partner, children, and healthcare professionals. Of the subdomains, fear of discrimination was negatively related to help-seeking intentions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study indicated that people's stigma beliefs and attitudes may pose barriers to help-seeking in the early stage of dementia. Our findings highlight the need to strengthen support for individuals with early dementia, while reducing people's fear of discrimination and prejudice against dementia in the long term.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144814656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study considers how people affected by dementia living in their own homes understand and interpret everyday aesthetics and what relevance this holds in their everyday lives.
Methods
Nine households, comprising ten family carers and seven people living with dementia, shared their self-identified meaningful moments of connection reflective of their personal understanding and interpretation of everyday aesthetics. Data collection involved a range of creative and self-initiated approaches, including scrapbooking, photography, and elicitation interviews. Data were analysed using reflective thematic analysis.
Results
Six discrete but interlinked themes were identified, namely: (1) Connection with others; (2) Connection with materiality; (3) Connection with self-image; (4) Connection with pride and societal value; (5) Connection with enjoyable activities; and (6) Connection with the lived environment, that revealed how people affected by dementia self-identify everyday aesthetic experiences in their daily lives.
Discussion
Our findings show these self-identified experiences span multiple physical and psychological domains of everyday life, each of which acts to support the personhood and identity of the person living with dementia. We suggest that development of a new model of care based on everyday aesthetic needs and informed by people affected by dementia, might bridge the gap between theory and practice in person-centred care. Going forward, developing care practices and support systems which focus on identifying and fulfilling the aesthetic needs of people living with dementia may offer a novel way to enhancing independence and personal well-being.
{"title":"Meaningful Moments of Connection: How People Affected by Dementia and Their Carers Living at Home Understand, Interpret and Experience Everyday Aesthetics","authors":"Sarah Fox, James Thompson, John Keady","doi":"10.1002/gps.70136","DOIUrl":"https://doi.org/10.1002/gps.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study considers how people affected by dementia living in their own homes understand and interpret everyday aesthetics and what relevance this holds in their everyday lives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nine households, comprising ten family carers and seven people living with dementia, shared their self-identified meaningful moments of connection reflective of their personal understanding and interpretation of everyday aesthetics. Data collection involved a range of creative and self-initiated approaches, including scrapbooking, photography, and elicitation interviews. Data were analysed using reflective thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Six discrete but interlinked themes were identified, namely: (1) Connection with others; (2) Connection with materiality; (3) Connection with self-image; (4) Connection with pride and societal value; (5) Connection with enjoyable activities; and (6) Connection with the lived environment, that revealed how people affected by dementia self-identify everyday aesthetic experiences in their daily lives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Our findings show these self-identified experiences span multiple physical and psychological domains of everyday life, each of which acts to support the personhood and identity of the person living with dementia. We suggest that development of a new model of care based on everyday aesthetic needs and informed by people affected by dementia, might bridge the gap between theory and practice in person-centred care. Going forward, developing care practices and support systems which focus on identifying and fulfilling the aesthetic needs of people living with dementia may offer a novel way to enhancing independence and personal well-being.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inequalities in Dementia Care and Research.","authors":"Pinar Soysal, Andrea Slachevski, Yaohua Chen","doi":"10.1002/gps.70143","DOIUrl":"https://doi.org/10.1002/gps.70143","url":null,"abstract":"","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":"e70143"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Table 3 should have the following labels for the columns and rows:
We apologize for this error.
表3中的列和行应该有以下标签：我们为这个错误道歉。
{"title":"Correction to “The Influence of a Dementia Diagnosis on Clinical Decision-Making in Dysphagia Management”","authors":"","doi":"10.1002/gps.70133","DOIUrl":"https://doi.org/10.1002/gps.70133","url":null,"abstract":"<p>Table 3 should have the following labels for the columns and rows:</p><p>We apologize for this error.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiying Cai, Zijie Zhuang, Weiming Lu, Yifei Wang, Zhiyuan Tian, Jie Ren, Jue Li, Jiaxin Chen, Guangbo Luo, Bin Lin, Xiali Yang
Objectives: There was a lack of in-depth understanding of the relationship between health literacy and depressive symptoms, and it was also unclear whether family health and perceived social support mediated this relationship and were negatively associated with the presence of depressive symptoms in older adults. This study aimed to explore the relationship between health literacy and depressive symptoms among older adults, while assessing the mediating roles of family health and perceived social support.
Methods: A cross-sectional study was conducted in China in 2021, involving 1147 participants aged 60 and older recruited using a nationwide multistage random sampling method. Ordered logistic regression and generalized additive models were employed to examine the association between health literacy and depressive symptoms, and the mediating effects of family health and perceived social support were assessed using mediation analysis with non-parametric bootstrapping. The Karlson-Holm-Breen (KHB) method was used to evaluate combined indirect associations, and subgroup mediation analyses were performed for "young-old" (65-74 years) and "old-old" (≥ 75 years) participants.
Results: Higher health literacy was associated with a lower likelihood of depressive symptoms (OR = 0.98, 95% CI: 0.97-0.99). Mediation analysis showed that the total indirect effect was thus estimated at -0.01, and the total effect of health literacy on depressive symptoms was approximately -0.03. The negative association between health literacy and depressive symptoms, as well as the mediating role of family health, remained significant in both the 65-74 and ≥ 75 age groups. However, the mediating effect of perceived social support was significant only in the 65-74 age group.
Conclusions: Health literacy is negatively associated with depressive symptoms in Chinese older adults and could be considered as a focus for intervention strategies. Enhancing health literacy may improve family health and perceived social support, and potentially lower depressive symptoms.
{"title":"The Association Between Health Literacy and Depressive Symptoms With the Mediation Role of Family Health and Perceived Social Support in Older Adults: A Nationwide Cross-Sectional Study in China.","authors":"Shiying Cai, Zijie Zhuang, Weiming Lu, Yifei Wang, Zhiyuan Tian, Jie Ren, Jue Li, Jiaxin Chen, Guangbo Luo, Bin Lin, Xiali Yang","doi":"10.1002/gps.70134","DOIUrl":"https://doi.org/10.1002/gps.70134","url":null,"abstract":"<p><strong>Objectives: </strong>There was a lack of in-depth understanding of the relationship between health literacy and depressive symptoms, and it was also unclear whether family health and perceived social support mediated this relationship and were negatively associated with the presence of depressive symptoms in older adults. This study aimed to explore the relationship between health literacy and depressive symptoms among older adults, while assessing the mediating roles of family health and perceived social support.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in China in 2021, involving 1147 participants aged 60 and older recruited using a nationwide multistage random sampling method. Ordered logistic regression and generalized additive models were employed to examine the association between health literacy and depressive symptoms, and the mediating effects of family health and perceived social support were assessed using mediation analysis with non-parametric bootstrapping. The Karlson-Holm-Breen (KHB) method was used to evaluate combined indirect associations, and subgroup mediation analyses were performed for \"young-old\" (65-74 years) and \"old-old\" (≥ 75 years) participants.</p><p><strong>Results: </strong>Higher health literacy was associated with a lower likelihood of depressive symptoms (OR = 0.98, 95% CI: 0.97-0.99). Mediation analysis showed that the total indirect effect was thus estimated at -0.01, and the total effect of health literacy on depressive symptoms was approximately -0.03. The negative association between health literacy and depressive symptoms, as well as the mediating role of family health, remained significant in both the 65-74 and ≥ 75 age groups. However, the mediating effect of perceived social support was significant only in the 65-74 age group.</p><p><strong>Conclusions: </strong>Health literacy is negatively associated with depressive symptoms in Chinese older adults and could be considered as a focus for intervention strategies. Enhancing health literacy may improve family health and perceived social support, and potentially lower depressive symptoms.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":"e70134"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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