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Silk Dye Effluent Induced Change in Ultra-Structure of Testis on Swiss Albino Male Mice Mus Musculus and Recovery by Moringa Oleifera Leaves Powder 丝染液对瑞士白化雄性小鼠睾丸超微结构的影响及辣木叶粉的恢复作用
Pub Date : 2023-09-06 DOI: 10.32553/ijmsdr.v7i5.989
Dr. Serina Khatun
The silk dye effluent is one of the most potential harmful chemicals liberated in the environment in an unexpected manner. Silk dye waste is widely used as a potent dyeing of yarn and fabrics in many countries and has been shown to produce some adverse health effects. This work focuses primarily on the effects of Moringa oleifera leaf extract on testis of silk dye effluent induced surface ultrastructure in Swiss albino mice Mus musculus. The testis has been taken an account for surface ultrastructural study. The mice were divided into 5 Groups i.e. Group I (Control), Group II (fed with 50% silk dye), Group III (fed with 100% silk dye), Group IV (mice fed with 50% dye treated with M. oleifera leaves powder), Group V (mice fed with 100% dye treated with M. oleifera leaves powder) have been taken for experiment. The dose of silk dye was 2ml/day to both groups II and III and M. oleifera leaf is given as per the standard dose (300mg/kg b.w) to both animals of group IV and V. Administration of silk dye waste result were demonstrated disrupted spermatids, cessation of seminiferous tubule cell, irregular cavity, lump of seminiferous tubules, disrupted interstitial cell and occupied spermatogonial cells but used of Moringa oleifera leafs powder it was significantly recovered the damage tissues has been observed. This study suggested that the extract may have beneficial effect on surface ultrastructural constituents such as Testis. Key words: Silk dye Effluent, Moringa oleifera leaf powder, Testis, Mus musculus, SEM for Ultra-Structure, Toxicity assessment.
丝绸染料废水是以一种意想不到的方式释放到环境中的最潜在的有害化学物质之一。在许多国家,丝绸染料废料被广泛用作纱线和织物的强力染色剂,并已被证明会产生一些不利的健康影响。本研究主要研究辣木叶提取物对丝素染料流出液诱导的瑞士白化小鼠睾丸表面超微结构的影响。对睾丸进行了表面超微结构研究。将小鼠分为5组,即ⅰ组(对照组)、ⅱ组(50%蚕丝染料)、ⅲ组(100%蚕丝染料)、ⅳ组(50%蚕丝染料加油棕叶粉)、ⅴ组(100%蚕丝染料加油棕叶粉)进行实验。II组和III组分别给丝染料2ml/d, IV组和v组均按标准剂量(300mg/kg b.w)给药。丝染料废物给药后,精子细胞破坏,精小管细胞停止,腔不规则,精小管肿块。间质细胞被破坏,精原细胞被占用,但辣木叶粉能明显恢复损伤组织。本研究提示其提取物可能对睾丸等表面超微结构成分有有益作用。关键词:丝绸染料废水,辣木叶粉,睾丸,小家鼠,超结构扫描电镜,毒性评价
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引用次数: 0
Asymptomatic Apical Hypertrophic Cardiomyopathy: Case Report and Review of Literature 无症状心尖肥厚性心肌病1例报告及文献复习
Pub Date : 2023-09-06 DOI: 10.32553/ijmsdr.v7i5.990
Akhil Mehrotra, Anurag Mehrotra, Mohammed Shaban, Shubham Kacker, Dr. Akhil Mehrotra
Apical hypertrophic cardiomyopathy (AHCM) is a known entity since its first introduction by Sakamoto and Yamaguchi. However, unlike classical hypertrophic cardiomyopathy (HCM), it is less explored in terms of its associated diagnosis and long-term outcomes. Given the increased availability and utilization of ultra-sophisticated cardiac imaging modalities, AHCM will be increasingly recognized as a distinct, clinically significant variant of classical HCM. It is associated with a wide spectrum of presentation ranging from asymptomatic course with incidental findings on imaging to rarely being associated with ventricular arrhythmias, syncope and sudden cardiac death (SCD). Contrast echocardiography is the most effective and diagnostic study when performed in the right setting with high suspicion on clinical and typical electrocardiogram (ECG) findings. Cardiac magnetic resonance imaging (CMR) has an equal diagnostic yield as a contrast echocardiogram. We are presenting a unique case report of a 57-year old gentleman with asymptomatic AHCM which was distinctly delineated after utilizing contrast tuned imaging (CnTI) echocardiography sans administration of intravenous contrast agents. This is a first case report of AHCM portrayed by this ingenious technology. Keywords: Apical Hypertrophic Cardiomyopathy, LV Contrast Echocardiography, Contrast Tuned Imaging, 4Dimensional XStrain Echocardiography.
根尖肥厚性心肌病(AHCM)自Sakamoto和Yamaguchi首次提出以来一直是一个已知的实体。然而,与经典肥厚性心肌病(HCM)不同,它在相关诊断和长期预后方面的探索较少。鉴于超复杂心脏成像方式的可用性和利用率的增加,AHCM将日益被认为是经典HCM的一种独特的、具有临床意义的变体。它与广泛的表现相关,从无症状的过程和偶然的影像学发现到很少与室性心律失常、晕厥和心源性猝死(SCD)相关。对比超声心动图是最有效的诊断研究,当在正确的设置高度怀疑临床和典型的心电图(ECG)的发现。心脏磁共振成像(CMR)与超声心动图具有同等的诊断率。我们报告一位57岁的无症状AHCM的男士,在没有静脉注射造影剂的情况下,利用对比度调整成像(CnTI)超声心动图清晰地描绘了他。这是用这种巧妙的技术描绘AHCM的首例病例报告。关键词:心尖肥厚性心肌病,左室超声造影,对比度调谐成像,4维x线超声心动图。
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引用次数: 0
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated with H1N1 Infection 与H1N1感染相关的抗利尿激素分泌不当综合征
Pub Date : 2023-08-31 DOI: 10.32553/ijmsdr.v7i4.988
None Yosra Cherif, None Samar Derbal, None Fatma Ben Dahmen, None Meya Abdallah
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is related to several conditions. However, there are few reports associated with H1N1 virus infection. We describe a 36 year old patient with SIADH admitted to our department if internal medicine with fever, cough and myalgias. The labooratory analysis showed serum hypo-osmolar hyponatremia and high level of urinary sodium concentration. All other biological analysis were within normal range. Moreover, All bacterial and fungal cultures, blood and urine cultures were all negative for any microbial pathogen. The thoraco-abdominal CT scan was normal. Rapid flu test was positive for influenza type A 15 days after. The patient recovered with intravenous infusion of hypertonic saline and fluid restriction and he did not received any anti-viral drug. Despite a strong relationship betwwen H1N1 virus infection and SIADH needs to be established, physicians should be aware of this potential seroius effect and should monitor the serum sodium closely. Keywords : H1N1 infection, inappropriate secretion of antidiuretic hormone, hyponatremia
抗利尿激素分泌不当综合征(SIADH)与几种情况有关。然而,与H1N1病毒感染有关的报道很少。我们描述了一位36岁的SIADH患者,他因发烧、咳嗽和肌痛而入院。实验室分析显示血清低渗性低钠血症和高水平尿钠浓度。其他生物学分析均在正常范围内。此外,所有细菌和真菌培养,血液和尿液培养均为阴性,任何微生物病原体。胸腹CT扫描正常。15天后,快速流感测试呈A型流感阳性。患者经静脉滴注高渗生理盐水及限液后恢复,未服用任何抗病毒药物。尽管H1N1病毒感染与SIADH之间的密切关系有待确定,但医生应意识到这种潜在的血清效应,并应密切监测血清钠。关键词:H1N1感染,抗利尿激素分泌不当,低钠血症
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引用次数: 0
Immediate Effect of Incentive Spirometer, Breathing Exercise and Active Cycle of Breathing Technique in CABG Patients: A Narrative Review 激励性肺活量计、呼吸运动和主动循环呼吸技术在冠脉搭桥患者中的即时效果:述评
Pub Date : 2023-07-22 DOI: 10.32553/ijmsdr.v7i3.987
Anshu Kumari, Dimple Choudhry, S.S. Lohchab, Gitanjali Sikka, Manshi
Background: Coronary artery bypass surgery is one of the widely used treatment as every year more than 1 million coronary artery bypass surgery procedure are performed around the world. The patients who have CABG are prone to pulmonary complications. Pulmonary complications are highly common after the CABG and the incidence is between 30% and 60%. These complications are the most significant contributor to morbidity, mortality and expenses associated with the hospitalization. Development of pulmonary complication is associated with impaired oxygenation and inconsistencies in gas exchange. Respiratory physiotherapy plays a vital role in postoperative CABG status. The interventions such as postoperative breathing exercises, effective coughing techniques, incentive spirometer and active cycle of breathing technique are used to limit lung volume decreases and atelectasis and to increase oxygenation after surgery. Objective: To find out the immediate effect of incentive spirometer, breathing exercise and active cycle of breathing technique on respiratory parameters and postoperative pulmonary complications in CABG patients. Study selection: This narrative review is conducted on databases from Pub med, Google scholar, ResearchGate and Cochrane library in Nov 2022. This review included 10 studies on the effect of incentive spirometer, breathing exercise and active cycle of breathing technique after CABG. Conclusion: It is concluded that incentive spirometer, breathing exercise and active cycle of breathing technique are effective in reducing postoperative pulmonary complications. But there are less studies which compares the two different type of  spirometer i.e. flow incentive spirometer and volume incentive spirometer in CABG patients and also there is no specific treatment protocol  for CABG patients. Hence, in order to establish a definitive protocol in patients with CABG, there is need to compare the effect of flow incentive spirometer and volume incentive spirometer along with breathing exercise and active cycle of breathing technique.
背景:冠状动脉搭桥手术是广泛使用的治疗方法之一,每年在世界范围内进行超过100万例冠状动脉搭桥手术。CABG患者容易出现肺部并发症。冠脉搭桥术后肺部并发症非常常见,发生率在30% ~ 60%之间。这些并发症是导致发病率、死亡率和住院费用的最主要因素。肺部并发症的发生与氧合受损和气体交换不一致有关。呼吸物理治疗在CABG术后状态中起着至关重要的作用。术后呼吸练习、有效咳嗽技术、刺激肺活量计和主动循环呼吸技术等干预措施可限制术后肺容量减少和肺不张,增加肺氧合。目的:探讨激励性肺活量计、呼吸运动及主动循环呼吸技术对冠脉搭桥患者呼吸参数及术后肺部并发症的直接影响。研究选择:本叙述性综述于2022年11月在Pub med、Google scholar、ResearchGate和Cochrane图书馆的数据库中进行。本文综述了10项关于冠脉搭桥术后激励性肺活量计、呼吸运动和主动循环呼吸技术效果的研究。结论:激励性肺活量计、呼吸运动及主动循环呼吸技术可有效减少术后肺部并发症。但是比较两种不同类型的肺活量计即流量刺激肺活量计和容积刺激肺活量计在CABG患者中的应用的研究较少,而且对于CABG患者也没有具体的治疗方案。因此,为了建立CABG患者的明确方案,有必要比较流量刺激肺活量计和容积刺激肺活量计与呼吸运动和主动循环呼吸技术的效果。
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引用次数: 0
William Syndrome Associated with Hypertrophic Cardiomyopathy and Severe Left Ventricular Outflow Obstruction: A Rare Case Report 威廉症候群合并肥厚性心肌病及严重左心室流出梗阻:一罕见病例报告
Pub Date : 2023-07-07 DOI: 10.32553/ijmsdr.v7i4.985
Akhil Mehrotra, Ujala Shakya, Mohammed Shaban, Shubham Kacker
Williams syndrome (WS), also referred to as Williams-Beuren syndrome, is a rare complex congenital developmental multisystem disorder, occurring in 1 per 20,000 live births, It is characterized by congenital heart defects (CHD), skeletal, renal anomalies, cognitive disorder, social personality disorder and notably dysmorphic Elfin-like facies. Supravalvular aortic stenosis is the most frequent cardiovascular abnormality in WS children. WS occurs as the result of a deletion of approximately 1.5-1.8 Mb on chromosome 7q11.23. The deletion is almost always denovo, however familial cases have been reported. Genetic study is usually required for a definitive diagnosis, but genetic testing is often unavailable in the developing countries and the combination of a typical clinical phenotype and echocardiographic profile helps to confirm the diagnosis. The prevalence of hypertrophic cardiomyopathy (HCM) is about 0.05 to 0.2% of general population and is extremely scarce in association with WS. The occurrence of HCM is a significant cause of sudden cardiac death (SCD) in any age group and a cause of heart failure. We are reporting an extraordinary case report of Williams’s syndrome with HCM complicated by severe left ventricular outflow obstruction (LVOT) in a 5 year old male child. Keywords:  Williams Syndrome, Hypertrophic Cardiomyopathy, Elfin Facies, LVOT obstruction, SAM, SCD.
Williams综合征(WS),也被称为Williams- beuren综合征,是一种罕见的先天性复杂发育多系统疾病,每20000例活产婴儿中就有1例发生,其特征是先天性心脏缺陷(CHD)、骨骼、肾脏异常、认知障碍、社会人格障碍和明显的畸形小精灵样相。瓣上主动脉瓣狭窄是WS患儿最常见的心血管异常。WS的发生是由于染色体7q11.23上大约1.5-1.8 Mb的缺失。这种缺失几乎总是先天性的,但也有家族性病例的报道。遗传研究通常需要明确的诊断,但基因检测在发展中国家往往是不可用的,典型的临床表型和超声心动图的组合有助于确认诊断。肥厚性心肌病(HCM)的患病率约为普通人群的0.05 ~ 0.2%,与WS相关极为罕见。HCM的发生是任何年龄组心源性猝死(SCD)的一个重要原因,也是心衰的一个原因。我们报告一个罕见的病例报告威廉姆斯综合征与HCM合并严重左心室流出梗阻(LVOT)在一个5岁的男孩。关键词:Williams综合征,肥厚性心肌病,Elfin相,LVOT梗阻,SAM, SCD
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引用次数: 0
Childhood Noonan Syndrome Presenting with Severe Pulmonary Stenosis: A Rare Case Report 儿童努南综合征表现为严重肺狭窄:一个罕见的病例报告
Pub Date : 2023-07-03 DOI: 10.32553/ijmsdr.v7i3.984
Akhil Mehrotra, Ujala Shakya, Shubham Kacker
Noonan syndrome [NS] is an autosomal dominant inherited condition that can be passed down through families. The incidence of NS is estimated to be between 1:1000 and 1:2500 live births. It causes abnormal development in many parts of the body. It is used to be called Turner-like syndrome. Though most of the cases are autosomally inherited some cases may be sporadic. We report a case of 13 year old male child presented to us with features of short stature, dysmorphic facies and severe pulmonary valvular stenosis without any family history of similar illness. Keywords: Noonan Syndrome, Pulmonary valvular stenosis.
努南综合征[NS]是一种常染色体显性遗传病,可通过家庭遗传。据估计,NS的发生率为活产1∶1000至1∶2500。它会导致身体许多部位发育异常。它过去被称为特纳样综合症。虽然大多数病例通常是遗传性的,但有些病例可能是散发性的。我们报告一例13岁男童,以身材矮小,畸形相和严重的肺瓣膜狭窄为特征,无家族病史。关键词:努南综合征;肺动脉瓣狭窄;
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引用次数: 0
A Study of Correlation between Sociodemographic Data and Anaemia Proxies among Women and Children 社会人口学数据与妇女和儿童贫血指标的相关性研究
Pub Date : 2023-06-30 DOI: 10.14445/23939117/ijms-v10i3p103
D. R, Aanandhalakshmi D, M. R
- The aim of this prospective cohort study, which was carried out over a period of six months at the government district headquarters medical college hospital in Nagapattinam, is to examine the relationship between sociodemographic information and proxies for anaemia in women, children, and the elderly. The most prevalent disease, anaemia, affects up to one-third of the world's population. Children under the age of 5, infants, and young children under the age of two, as well as women who are of reproductive age, are the population groups most at risk for anaemia. In the study, 60 people with anaemia and only 53 people from 11 to over 50 years old had their Spearman correlation performed. Severe anaemia is the most prevalent type of anaemia, and in this study, women over 50 were the age group most frequently affected. The relationship between various sociodemographic parameters and laboratory characteristics is demonstrated by the spearman correlation. The frequency distribution of anaemia proxies, sociodemographic factors, and lifestyle traits are found to correlate directly with anaemia in patients.
-这项前瞻性队列研究在Nagapattinam政府区总部医学院医院进行了为期6个月的研究,目的是研究社会人口统计信息与妇女、儿童和老年人贫血指标之间的关系。最普遍的疾病是贫血,影响着世界三分之一的人口。5岁以下儿童、婴儿和两岁以下幼儿以及育龄妇女是最易患贫血的人群。在这项研究中,60名贫血患者和53名11岁至50岁以上的人进行了斯皮尔曼相关性测试。严重贫血是最普遍的贫血类型,在这项研究中,50岁以上的妇女是最常受影响的年龄组。各种社会人口学参数和实验室特征之间的关系由spearman相关证明。发现贫血指标的频率分布、社会人口统计学因素和生活方式特征与患者的贫血直接相关。
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引用次数: 0
The Effect of Antipsychotic Drugs on Salivary Flow Rate and Dental Caries in Schizophrenic Patients 抗精神病药物对精神分裂症患者唾液流率及龋齿的影响
Pub Date : 2023-06-30 DOI: 10.14445/23939117/ijms-v10i3p102
Atiyah Hasin, Mozammal Hossain, Anwar Parvez Bhuiyan, Ali Asgor Moral Md.
- This study sought to ascertain how antipsychotics affected patients with schizophrenia's salivary flow and risk of dental caries. 24 individuals with recently diagnosed schizophrenia who were given antipsychotic medication by a licensed psychiatrist made up the study population. Patients with schizophrenia who are on first-generation antipsychotic medications make up 12 participants, while patients with schizophrenia who are taking second-generation antipsychotic medications make up another 12 participants. Participants' oral health status was assessed using the decay index/missing/filled teeth (DMFT) and salivary flow rate. The results of this study indicate that in the first-generation group, 50.0% of patients were hydrated for 30 to 60 seconds, 66.7% of patients had foamy or bubbly saliva, 50% of patients had a PH of 6.0 to 6.8, and the mean salivation rate was 0.13 ± 0.06 milliliters per minute. In the second-generation group B, the mean salivation rate was 0.24 ± 0.09 (ml/min), 66.7% of patients had frothy or bubbly saliva, 66.7% had saliva with a PH of 6.8–7.8, and 58.3% had hydration 30 seconds. In terms of DMFT, 41.6 and 41.7% of patients in both groups they have had DMFT 0 at day zero. The DMFT score of zero, however, rapidly reduced in the second-generation group while remaining constant in the first-generation group. At 12 months, the variations in DMFT between the two groups were statistically significant (P <0.005). In conclusion, 2nd generation drug recipients with schizophrenia had much better oral health than the 1st generation group.
这项研究试图确定抗精神病药物如何影响精神分裂症患者的唾液流动和龋齿的风险。24名最近被诊断为精神分裂症的患者由有执照的精神科医生给予抗精神病药物,他们组成了研究人群。服用第一代抗精神病药物的精神分裂症患者共12人,服用第二代抗精神病药物的精神分裂症患者共12人。使用蛀牙指数/缺牙/补牙(DMFT)和唾液流率评估参与者的口腔健康状况。本研究结果表明,在第一代组中,50.0%的患者水分持续30 ~ 60秒,66.7%的患者唾液有泡沫或气泡,50%的患者PH值为6.0 ~ 6.8,平均流涎率为0.13±0.06毫升/分钟。第二代B组平均流涎率为0.24±0.09 (ml/min), 66.7%的患者唾液有泡沫或泡状,66.7%的患者唾液PH值为6.8 ~ 7.8,58.3%的患者30秒水化。在DMFT方面,两组中分别有41.6%和41.7%的患者在第0天出现DMFT。然而,DMFT得分为零在第二代组迅速下降,而在第一代组保持不变。12个月时,两组DMFT差异有统计学意义(P <0.005)。综上所述,第二代精神分裂症患者的口腔健康状况明显好于第一代。
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引用次数: 0
Evaluation of Arthrocentesis with and without Platelet Rich Plasma in the Internal Derangement of Temporomandibular Joint 富血小板血浆置换与不富血小板血浆置换对颞下颌关节内部紊乱的影响
Pub Date : 2023-06-30 DOI: 10.14445/23939117/ijms-v10i3p101
Habibullah A K M, Wares Uddin Md., A. Md., Wahiduj Jaman, M. Md., Mozammal Hossain
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引用次数: 0
Comparison of Coronary Diseases by Coronary Angiography between Diabetic and Non-Diabetic Patients 糖尿病与非糖尿病患者冠状动脉造影诊断冠心病的比较
Pub Date : 2023-04-30 DOI: 10.14445/23939117/ijms-v10i2p101
Aymen Shaher, Bassem Marof, Arige Boubou
{"title":"Comparison of Coronary Diseases by Coronary Angiography between Diabetic and Non-Diabetic Patients","authors":"Aymen Shaher, Bassem Marof, Arige Boubou","doi":"10.14445/23939117/ijms-v10i2p101","DOIUrl":"https://doi.org/10.14445/23939117/ijms-v10i2p101","url":null,"abstract":"","PeriodicalId":14075,"journal":{"name":"International Journal of Medical Science And Diagnosis Research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76954956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Medical Science And Diagnosis Research
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