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The Relationship between Sickle Cell Disease and Pulmonary Hypertension in Adults 成人镰状细胞病与肺动脉高压的关系
Pub Date : 2022-02-25 DOI: 10.14445/23939117/ijms-v9i2p101
Mariam Alabdo, Firas Hussein, Basem Marouf
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引用次数: 0
Analytical Study of Thrombocytopenia in Pregnant Women in Tishreen University Hospital (Causes, Complications, Management) 天津大学附属医院孕妇血小板减少症分析研究(原因、并发症、处理)
Pub Date : 2022-02-25 DOI: 10.14445/23939117/ijms-v9i1p102
A. Marouf, F. Hussein, Louai Hasan
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引用次数: 1
Flow Cytometry based 'Acute Myeloid Leukemia Maturity Score' is a Novel Marker for Predicting Relapse in Acute Myeloid Leukemia: A Prospective Observational Study 基于流式细胞术的“急性髓性白血病成熟度评分”是预测急性髓性白血病复发的新标志物:一项前瞻性观察研究
Pub Date : 2022-02-24 DOI: 10.32553/ijmsdr.v6i2.910
P. Mishra, Seema Tyagi, Preeti Tripathi, Rahul Sharma, H P Pati, Manoranjan Mahapatra
Objectives:  A novel flow cytometric ‘AML Maturity Score (AMS)’ classifying patients into AML-immature (AML-im) and AML-mature (AML-ma) based on CD34, CD117 and Tdt expression on blasts correlated with induction remission, relapse free survival and overall survival in previous studies. We aimed to study the correlation between AMS and ELN risk group and outcomes- induction remission (IR), time to remission (TTR) and relapse. Material and Methods:  This was a combined prospective and retrospective study of 104 AML patients over 30 months. Flow cytometry based quantitative expression of CD34, TdT and CD117 on blasts was used for calculating AMS and additional tube for CD34+CD38-CD123+ cells was put at diagnosis in 47 patients prospectively studied. The patients received 1-2 cycles of standard induction (3+7) comprising Daunorubicin (60mg/m2/day for 3 days) and Cytarabine (continuous infusion 100mg/m2/day for 7 days). Data was collected on the clinical and laboratory parameters, cytogenetics and molecular profile of these patients who were followed up for IR, TTR and relapse. Results: Of 104 patients, AML-im were 86.6% (90/104) and AML-ma were 13.4% (14/104). Patients were classified as – favorable risk (28.8%), intermediate risk (50%) and adverse risk (21.1%) on the basis of ELN 2017. Of 104 patients, 74 attained IR and of 65 patients followed up over mean period of 18 months, 27 relapsed. The mean AMS was significantly more in patients who attained IR (p=0.003). On classifying patients as AML-im and AML-ma, TTR (p=0.000) and relapses (p=0.043) were significantly higher in AML-im group. Conclusion:  AMS is a novel flow cytometry based potential marker for predicting relapses in AML patients.
目的:建立一种新的流式细胞技术“AML成熟度评分(AMS)”,根据细胞中CD34、CD117和Tdt的表达与诱导缓解、无复发生存期和总生存期的相关性,将患者分为AML-未成熟(AML-im)和AML-成熟(AML-ma)。我们的目的是研究AMS和ELN风险组与诱导缓解(IR)、缓解时间(TTR)和复发的相关性。材料和方法:这是一项为期30个月的104例AML患者的前瞻性和回顾性联合研究。采用流式细胞术定量表达CD34、TdT和CD117,计算AMS,并将CD34+CD38-CD123+细胞附加试管用于诊断47例患者的前瞻性研究。患者接受1-2个周期的标准诱导(3+7),包括柔红霉素(60mg/m2/天,连续3天)和阿糖胞苷(100mg/m2/天,连续7天)。收集这些患者的临床和实验室参数、细胞遗传学和分子特征,并随访IR、TTR和复发情况。结果:104例患者中AML-im占86.6% (90/104),AML-ma占13.4%(14/104)。根据ELN 2017将患者分为-有利风险(28.8%)、中度风险(50%)和不良风险(21.1%)。104例患者中,74例达到IR, 65例患者平均随访18个月,27例复发。达到IR的患者的AMS平均值显著增加(p=0.003)。AML-im组和AML-ma组TTR (p=0.000)和复发(p=0.043)明显高于AML-im组。结论:AMS是一种新的基于流式细胞术的预测AML复发的潜在标志物。
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引用次数: 0
EFFECT OF MATERNAL BODY MASS INDEX ON THE MODE OF DELIVERY AND NEONATAL OUTCOME: A TERTIARY CARE HOSPITAL BASED STUDY IN SOLAN, HIMACHAL PRADESH. 产妇体重指数对分娩方式和新生儿结局的影响:喜马偕尔邦索兰三级保健医院的研究。
Pub Date : 2022-02-19 DOI: 10.32553/ijmsdr.v6i2.912
S. Aggarwal, M. Behal, N. Singal, S. Minhas, Sheetal Dagar
INTRODUCTION: Obesity is a global health problem characterised as a pandemic issue by the World Health Organization (WHO), with a higher prevalence in females than males. During pregnancy, it is considered a high-risk state because it is associated with maternal complications like preeclampsia, gestational diabetes, obstetric interventions like caesarean delivery, postpartum haemorrhage; and fetal complications like macrosomia, poor apgar scores. BMI is a commonly used indicator which can be used to classify subjects on the basis of weight.AIM: This study aims to find the prevalence of normal weight, overweight and obese pregnant women defined by body mass index (BMI) according to the WHO classification and to study the associations between maternal BMI, the mode of delivery and neonatal outcome.MATERIAL AND METHODS: 200 pregnant women admitted for delivery in the department of Obstetrics & Gynaecology were studied, height and weight were recorded from reliable antenatal records (recorded within two months of gestation). The Body Mass Index was calculated and patients were divided into four categories: Category I: underweight; Category II: normal BMI; Category III: Overweight; Category IV: Obese. The feto-maternal outcomes were studied.RESULTS: On evaluation of 200 nulliparous antenatal women with singleton term gestation, 1.5% were underweight, 33% had normal BMI, 56% were overweight and 9.5% were obese. The prolongation of labour was seen in subjects with BMI more than 25 kg/m2. Overweight patients had more instrumental deliveries and obese patients had a higher tendency for prolonged labour and caesarean deliveries. Neonatal outcomes were poor for obese and overweight patients as compared to normal BMI because more neonates required resuscitation at birth, had low Apgar scores and were small for gestational age. Maternal complications like Hypothyroidism, preeclampsia and gestational diabetes occurred more commonly in the obese category.CONCLUSION: In our institution, majority of patients were found to be overweight. Adverse perinatal outcomes were seen more often in the obese patients. Hence, obesity must be identified as a risk factor for adverse pregnancy outcomes.
导言:肥胖是一个全球性的健康问题,被世界卫生组织(世卫组织)定性为一个大流行病,女性的患病率高于男性。在怀孕期间,它被认为是一种高风险状态,因为它与先兆子痫、妊娠糖尿病、剖腹产等产科干预措施、产后出血等孕产妇并发症有关;还有胎儿并发症,比如巨大儿,阿普加评分低。BMI是一种常用的指标,可以根据体重对受试者进行分类。目的:本研究旨在根据WHO的体重指数(BMI)分类,了解正常体重、超重和肥胖孕妇的患病率,并研究产妇体重指数、分娩方式和新生儿结局之间的关系。材料和方法:对200名在妇产科住院分娩的孕妇进行研究,从可靠的产前记录(妊娠2个月内记录)中记录身高和体重。计算体重指数,将患者分为四类:第一类:体重过轻;第二类:BMI正常;第三类:超重;第四类:肥胖。研究胎母结局。结果:对200例单胎足月无产孕妇进行评价,体重不足1.5%,BMI正常33%,超重56%,肥胖9.5%。体重指数大于25kg /m2的分娩时间延长。超重患者有更多的器械分娩,肥胖患者有更大的延长分娩和剖腹产的倾向。与正常体重指数相比,肥胖和超重患者的新生儿结局较差,因为更多的新生儿在出生时需要复苏,阿普加评分较低,胎龄较小。产妇并发症如甲状腺功能减退、先兆子痫和妊娠期糖尿病在肥胖人群中更为常见。结论:本院绝大多数患者体重超标。不良围产期结局在肥胖患者中更为常见。因此,肥胖必须被确定为不良妊娠结局的一个危险因素。
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引用次数: 0
Role of Gentamicin Loaded Collagen on Compound Fracture Internal Fixation 庆大霉素负载胶原蛋白在复合骨折内固定中的作用
Pub Date : 2022-02-19 DOI: 10.32553/ijmsdr.v6i2.919
Nitin Sanadhya
Introduction:  In the today’s world with faster ways of transportation  high velocity accidents and  the compound fracture are increasing day by day producing a challenge preventing post operative  wound infections after internal fixation of  fracture. Materials and Methods: 50 patients of compound fractures were included in the study and were randomly divided in 2 groups of 25 each . Both the groups undergone internal fixation with stainless  steel implant and one group wound is closed with gentamicin loaded collagen in it and other group without it Method: In both the groups same process of  and lavage  is used and  fractures were  fixed internally fixed . A group has 25 patients in which after internal fixation the gentamicin loaded collagen is placed  inside and in B group after internal fixation  wound is closed without gentamicin loaded collagen. Results: In  group A where Gentamicin loaded collagen was placed wound infection was there in 2 patients . In  Group B were no gentamicin loaded collagen was used  9 patietns has infections. P value  0.0275 Discussion: After surgery wound is assessed for post operative infection on  2 nd post op day  14 day  at 4 weeks    6 weeks   3 months  and 6 months Conclusion: The Author  believe  that  use of gentamicin loaded collagen significantly reducing the chance of infection in  compound fractures surgeries. Keywords: compound fracture, gentamicin loaded collagen, post operative infection
导语:随着交通方式的快速发展,高速事故和复合性骨折日益增多,对骨折内固定术后伤口感染的预防提出了挑战。材料与方法:选择50例复合骨折患者,随机分为两组,每组25例。两组均采用不锈钢假体内固定,一组用胶原蛋白庆大霉素封闭创面,另一组不应用胶原蛋白庆大霉素封闭创面。方法:两组均采用相同的灌洗工艺,骨折内固定。A组25例,内固定后置入庆大霉素负载的胶原蛋白,B组内固定创面闭合后不置入庆大霉素负载的胶原蛋白。结果:A组加载庆大霉素胶原蛋白组2例出现创面感染。B组未使用庆大霉素加载胶原蛋白,9例发生感染。讨论:术后第2天、第14天、第4周、第6周、第3个月、第6个月评估术后伤口感染情况。结论:作者认为在复合骨折手术中使用庆大霉素加载胶原蛋白可显著减少感染的发生。关键词:复合型骨折,庆大霉素胶原蛋白,术后感染
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引用次数: 0
To Study the Prevalence of Vitamin D Deficiency in Third Trimester and Feto-Maternal Outcome. 研究妊娠晚期维生素D缺乏症的患病率和胎母结局。
Pub Date : 2022-02-19 DOI: 10.32553/ijmsdr.v6i2.913
Sheetal Dagar, Monika Gupta, Monika Jindal, S. Minhas, S. Aggarwal
Aim: To estimate the prevalence of vitamin D deficiency in third trimester and itscorrelation with feto-maternal outcome Material and Methods: Present study was conducted 200 pregnant women who were admitted to the labor room in the third trimester in the department of Obstetrics & Gynecology of Maharishi Markandeshwar Medical College and Hospital, Solan (H.P.) for delivery after fulfilling the inclusion & exclusion criteria. Detailed history including complete demographic information, past medical history, dietary history, previous menstrual & obstetric history, any antenatal complications. Delivery details including mode of delivery, birth weight and APGAR scores were recorded on the proforma. Serum vitamin D was estimated fromthe maternal blood sample. Vitamin D deficiency was defined as 25(OH) D levels in blood less than 20 ng/ml, and insufficiency of vitamin D was defined as 25(OH) D levels between 20-30 ng/ml.Results: In this study, there was a high prevalence of vitamin D deficiency (93.5%) in the pregnant women though there was no significant difference in socio-demographic factors in the deficient and non-deficient group. Present study showed that the proportion of vitamin D deficient pregnant women having maternal complications and NICU admission was statistically significant as compared to the non-deficient group (p=0.0109) and (p=0.0384) respectively. Conclusion: Maternal complications, increased cesarean section rate and NICU admission weremore associated with hypovitaminosis D but any causal relationship between vitaminD deficiency and pregnancy complications was not found in this study design. Wepropose that vitamin D supplementation is simple and economical, and hence weshould incorporate vitamin D testing, increase its awareness and treat its deficiency inadolescence, pre-conceptional period or 1st trimester to avoid maternal complicationsand poor fetal outcome. Keywords: Vitamin D Deficiency, Third trimester, Fetal outcome, Maternal outcomex
目的:评估妊娠晚期维生素D缺乏症的患病率及其与胎母结局的相关性。资料与方法:本研究选取了200例妊娠晚期在索兰Maharishi Markandeshwar医学院及索兰医院(H.P.)妇产科接受产房分娩并符合纳入和排除标准的孕妇。详细的历史包括完整的人口统计信息,过去的病史,饮食史,以前的月经和产科史,任何产前并发症。分娩细节包括分娩方式、出生体重和APGAR评分记录在表格上。血清维生素D由母体血液样本估算。维生素D缺乏被定义为血液中25(OH) D水平低于20 ng/ml,维生素D不足被定义为25(OH) D水平在20-30 ng/ml之间。结果:在本研究中,孕妇维生素D缺乏症的患病率很高(93.5%),但缺乏组和非缺乏组的社会人口统计学因素无显著差异。本研究显示,与非维生素D缺乏组相比,维生素D缺乏孕妇发生孕产妇并发症和入住新生儿重症监护病房的比例分别有统计学意义(p=0.0109)和(p=0.0384)。结论:孕妇并发症、剖宫产率增加和新生儿重症监护病房入院与维生素D缺乏症的相关性更大,但本研究设计未发现维生素D缺乏症与妊娠并发症之间存在因果关系。我们建议补充维生素D是简单而经济的,因此我们应结合维生素D检测,提高对维生素D的认识,并在青春期、孕前期或妊娠早期治疗维生素D缺乏,以避免产妇并发症和不良胎儿结局。关键词:维生素D缺乏,妊娠晚期,胎儿结局,产妇结局
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引用次数: 0
COVID 19 & its Different Colours- An Autobiographical¸Case Report of a Physician Suffering Twice with COVID Atypical Symptoms Despite Vaccinated. COVID - 19及其不同的颜色——一位医生在接种疫苗后两次出现COVID - 19非典型症状的自传式病例报告。
Pub Date : 2022-02-19 DOI: 10.32553/ijmsdr.v6i2.918
Manuj Kumar Sarkar, U. Rakesh, S. Dey, B. Munshi
COVID 19 caused by severe acute respiratory syndrome corona virus 2 (SARS CoV2). Initial infection started from China in December 2019. It became pandemic and till date it has infected 399 million people all over the world. First wave was associated with more panic situation and it has impacted mental health globally. As time passed and with subsequent waves, we have learnt to deal with the stress caused by COVID 19. I am presenting my case of suffering from COVID 19 twice despite vaccinated and its psychological impact on mental status. 
COVID - 19由严重急性呼吸综合征冠状病毒2 (SARS CoV2)引起。首次感染始于2019年12月的中国。它成为流行病,迄今为止,它已经感染了全世界3.99亿人。第一波与更多的恐慌情况有关,并影响了全球的心理健康。随着时间的推移和随后的浪潮,我们已经学会了应对COVID - 19带来的压力。尽管我接种了疫苗,但我还是两次患了COVID - 19,并对精神状态产生了心理影响。
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引用次数: 1
Isolated Miliary Tuberculosis of Brain in an Immuno-Competent Patient, Presenting as Cerebellar Ataxia 免疫正常患者的分离性脑结核,表现为小脑共济失调
Pub Date : 2022-02-18 DOI: 10.32553/ijmsdr.v6i2.916
Adhip Arora
We are reporting an unusual case of a 26-year-old immunocompetent patient of miliary tuberculosis of cerebellum with meningitis and lung involvement, presenting with ataxia without any evidence of systemic inflammation. Since, prognosis depends on correct diagnosis and timely treatment, recognition and prompt diagnosis are important for overall outcome. 
我们报告一个不寻常的病例,一个26岁的免疫功能正常的小脑军性结核合并脑膜炎和肺部受累的病人,表现为共济失调,没有任何全身炎症的证据。由于预后取决于正确的诊断和及时的治疗,识别和及时诊断对总体结果很重要。
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引用次数: 0
Umbilical Cord Coiling Index Sonographic Evaluation in its Relationship with Perinatal Outcome and Late Second Trimester 脐带盘绕指数超声评价与围产期结局及孕中期晚期的关系
Pub Date : 2022-02-01 DOI: 10.32553/ijmsdr.v6i1.909
Balameenakshi, G. Yuvabalakumaran
Objectives: To assess the relationship between perinatal results along with umbilical cord coiling index derived from sonographer solutions. Study Design: This predictive research was executed in the OBG department of radiology at Vinayaka missions Kirupananda Variyar medical college and hospital of Medical Sciences, Salem, India from April, 2021 to September, 2021. Of the 60 patients included in the study, single pregnancies with direct vaginal / LSCS babies, regardless of equality, with active delivery from the second trimester to final pregnancy. From the results of the ultrasound, the "umbilical cord coiling index" was correlated and calculated with different perinatal criteria such as equivalence, gestational hypertension (PIH), gestational diabetes (GD) and l gestational age (in weeks), Delivery method and Apgar score.  Fisher tests and Chi-squared were assist to determine the importance of the parameter findings. Results: The current results of the ultrasound evaluation show that the UCI provides a significant correlation with hypocrite coils (UCI> 90%), babies PIH (p-value <0.05), and GDM (p-value 0.044) Hypocoiled (UCI<10%) and Hypercoiled cords (p <0.05) were significantly related to the Apgar score (p less than 0.05). Conclusion: hypercoiled Coils or UCI> 90% is associated with IUGR and is part of primary perinatal results such as PIH and GDM. Both hypocoiled and hypercoied cords, and UCI <10%, linked to the Apgar score for the perinatal results, thus showing a greater correlation with the UCI index. Keywords: Hypercoiling umbilical cord, Umbilical cord coiling index, Hypocoiling umbilical cord  
目的:探讨超声检查结果与脐带盘绕指数之间的关系。研究设计:该预测研究于2021年4月至2021年9月在印度塞勒姆的Kirupananda varyar医学院和医学科学医院的Vinayaka特派团的OBG放射科进行。在研究中包括的60例患者中,单次妊娠直接阴道/ LSCS婴儿,无论是否平等,从妊娠中期到妊娠末期积极分娩。根据超声结果,将“脐带绕线指数”与妊娠等值、妊娠高血压(PIH)、妊娠糖尿病(GD)、1胎龄(周)、分娩方式、Apgar评分等不同围产儿标准进行关联计算。Fisher检验和卡方检验有助于确定参数发现的重要性。结果:目前超声评估结果显示,UCI与伪伪性线圈(UCI> 90%)有显著相关性,婴儿PIH (p值90%)与IUGR相关,是PIH和GDM等主要围产期结果的一部分。低卷绕和高卷绕的脐带,以及UCI <10%,都与围产期结果的Apgar评分相关,因此与UCI指数的相关性更大。关键词:高盘绕脐带,脐带盘绕指数,低盘绕脐带
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引用次数: 0
Microflora Responsible for Failure of RCT : A Review 导致随机对照试验失败的微生物群综述
Pub Date : 2022-02-01 DOI: 10.32553/ijmsdr.v6i1.908
Anil K. Tomer, Nivedita Saini, Shivangi Jain, G. Sabharwal, Ayan Guin
Endodontic treatment failure can be caused by a variety of factors, including bacterial persistence, improperly cleaned and obturated root canals, faulty coronal seal (leakage), and untreated canals (missed canals). The presence of bacteria such as Enterococcus (E.) faecalis inside the root canal system is the most common cause of endodontic failure. These bacteria are more resistant to disinfectants, resulting in an infection that persists intra-radicularly or extra-radicularly. Many other microorganism are also responsible for failure of root canal treatment, resulting in endodontic flare-up . This review article will discuss about the causes of failure of root canal treatment ,pathogenesis and strategies by which microbes persist in root canal, method of eradication of such microorganism and management of such cases. Keywords: Enterococcus, Enterococcus
根管治疗失败可由多种因素引起,包括细菌残留、不正确清洁和封闭根管、冠状密封缺陷(渗漏)和未处理的根管(漏根管)。粪肠球菌(肠球菌)等细菌在根管系统内的存在是导致根管失效的最常见原因。这些细菌对消毒剂有更强的抵抗力,导致在根内或根外持续感染。许多其他微生物也是导致根管治疗失败的原因,导致牙髓病发作。本文就根管治疗失败的原因、微生物在根管内存留的机理及对策、根治方法及处理等方面作一综述。关键词:肠球菌;肠球菌
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引用次数: 0
期刊
International Journal of Medical Science And Diagnosis Research
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