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Factors Predicting Fetal Growth Restriction and Fetal Cardiac Remodeling. 预测胎儿生长受限和胎儿心脏重塑的因素
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S483150
XiaoLe Chen, Lili Xiao, Daozhu Wu, Saida Pan

Objective: This study aimed to investigate factors influencing fetal growth restriction (FGR) occurrence and assess the clinical significance of fetal cardiac parameters in FGR prediction.

Methods: Pregnant women with clinically suspected FGR (n=179) and uncomplicated pregnancies (n=53) were included. All had undergone routine obstetric ultrasonography and fetal echocardiography. Umbilical artery flow (UAF) and fetal cardiac parameters (left atrial transverse diameter (LAd), right atrial transverse diameter (RAd), left ventricular transverse diameter (LVd), right ventricular transverse diameter (RVd), foramen ovale width, atrial septum diameter, interventricular septal thickness, left ventricular posterior wall thickness, right ventricular free wall thickness, aortic diameter, pulmonary artery diameter, mitral E velocity, mitral A velocity, tricuspid E velocity, tricuspid A velocity, aortic valve peak flow velocity, and pulmonary valve peak flow velocity) were detected. Follow up was conducted until birth, various fetal clinical parameters were collected: maternal body mass index (BMI), hypertensive disorders complicating pregnancy (HDCP), abnormal umbilical artery flow, placental or umbilical cord anomalies, low amniotic fluid volume, preterm birth, emergency cesarean delivery, maternal height, maternal age, gestational diabetes mellitus (GDM), hypothyroidism, assisted reproductive technology (ART), parity, and neonatal gender. Participants were categorized into confirmed FGR (n=119) and control (n=113) groups based on neonatal birth weight.

Results: Significant differences were observed between groups in maternal BMI, HDCP, abnormal UAF, placental or umbilical cord anomalies, low amniotic fluid volume, preterm birth, and emergency cesarean delivery. FGR was positively related to abnormal UAF, placental or umbilical cord anomalies, preterm birth and emergency cesarean delivery and negatively to maternal BMI (r=-0.276). Compared to the control group, the FGR group exhibited significantly larger RAd, RVd, RA/LA, and RV/LV.

Conclusion: Fetal growth-restricted fetuses have enlarged right heart structures. Fetal cardiac examinations are valuable for early FGR diagnosis, potentially improving neonatal body weight and reducing adverse pregnancy outcomes.

目的本研究旨在探讨影响胎儿生长受限(FGR)发生的因素,并评估胎儿心脏参数在预测FGR中的临床意义:方法:纳入临床疑似FGR孕妇(179人)和无并发症孕妇(53人)。所有孕妇均接受了常规产科超声检查和胎儿超声心动图检查。还检测了左心室后壁厚度、右心室游离壁厚度、主动脉直径、肺动脉直径、二尖瓣 E 峰流速、二尖瓣 A 峰流速、三尖瓣 E 峰流速、三尖瓣 A 峰流速、主动脉瓣峰流速和肺动脉瓣峰流速。随访至胎儿出生,收集各种胎儿临床参数:产妇体重指数(BMI)、妊娠并发高血压疾病(HDCP)、脐动脉血流异常、胎盘或脐带异常、羊水量过少、早产、紧急剖宫产、产妇身高、产妇年龄、妊娠糖尿病(GDM)、甲状腺功能减退症、辅助生殖技术(ART)、胎次和新生儿性别。根据新生儿出生体重将参与者分为确诊 FGR 组(119 人)和对照组(113 人):结果:在产妇体重指数、HDCP、UAF异常、胎盘或脐带异常、羊水量过少、早产和紧急剖宫产方面,观察到组间存在显著差异。FGR与UAF异常、胎盘或脐带异常、早产和紧急剖宫产呈正相关,与产妇体重指数呈负相关(r=-0.276)。与对照组相比,FGR组的RAd、RVd、RA/LA和RV/LV明显增大:结论:胎儿生长受限会导致右心结构增大。结论:胎儿生长受限会导致右心结构增大,胎儿心脏检查对早期诊断 FGR 很有价值,有可能改善新生儿体重并减少不良妊娠结局。
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引用次数: 0
Machine Learning Research Trends in Traditional Chinese Medicine: A Bibliometric Review. 中医药中的机器学习研究趋势:文献计量学综述。
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S495663
Jiekee Lim, Jieyun Li, Mi Zhou, Xinang Xiao, Zhaoxia Xu

Background: Integrating Traditional Chinese Medicine (TCM) knowledge with modern technology, especially machine learning (ML), has shown immense potential in enhancing TCM diagnostics and treatment. This study aims to systematically review and analyze the trends and developments in ML applications in TCM through a bibliometric analysis.

Methods: Data for this study were sourced from the Web of Science Core Collection. Data were analyzed and visualized using Microsoft Office Excel, Bibliometrix, and VOSviewer.

Results: 474 documents were identified. The analysis revealed a significant increase in research output from 2000 to 2023, with China leading in both the number of publications and research impact. Key research institutions include the Shanghai University of Traditional Chinese Medicine and the China Academy of Chinese Medical Sciences. Major research hotspots identified include ML applications in TCM diagnosis, network pharmacology, and tongue diagnosis. Additionally, chemometrics with ML are highlighted for their roles in quality control and authentication of TCM products.

Conclusion: This study provides a comprehensive overview of ML applications' development trends and research landscape in TCM. The integration of ML has led to significant advancements in TCM diagnostics, personalized medicine, and quality control, paving the way for the modernization and internationalization of TCM practices. Future research should focus on improving model interpretability, fostering international collaborations, and standardized reporting protocols.

背景:将传统中医(TCM)知识与现代技术,特别是机器学习(ML)相结合,在提高中医诊断和治疗方面显示出巨大的潜力。本研究旨在通过文献计量学分析,系统回顾和分析 ML 在中医药领域应用的趋势和发展:本研究的数据来源于 Web of Science Core Collection。数据使用 Microsoft Office Excel、Bibliometrix 和 VOSviewer 进行分析和可视化:确定了 474 篇文献。分析表明,从 2000 年到 2023 年,中国的研究成果大幅增加,在论文数量和研究影响力方面均处于领先地位。主要研究机构包括上海中医药大学和中国中医科学院。主要研究热点包括中医诊断、网络药理学和舌诊中的 ML 应用。此外,研究还强调了化学计量学与 ML 在中药产品质量控制和鉴定中的作用:本研究全面概述了 ML 在中医药领域的应用发展趋势和研究现状。ML 的集成在中医诊断、个性化医疗和质量控制方面取得了重大进展,为中医药实践的现代化和国际化铺平了道路。未来的研究应侧重于提高模型的可解释性、促进国际合作和标准化报告协议。
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引用次数: 0
A Study on the Current Situation and Related Factors of Personal Mastery in Patients with Chronic Heart Failure: A Cross-Sectional Study [Letter]. 慢性心力衰竭患者的个人掌握现状及相关因素研究:一项横断面研究[信]。
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S503136
Jiong Zhang, Yan Pan
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引用次数: 0
Adapting Artificial Intelligence Concepts to Enhance Clinical Decision-Making: A Hybrid Intelligence Framework. 调整人工智能概念以加强临床决策:混合智能框架。
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S497753
Takanobu Hirosawa, Tomoharu Suzuki, Tastuya Shiraishi, Arisa Hayashi, Yoichi Fujii, Taku Harada, Taro Shimizu

Purpose: Artificial intelligence (AI) holds great potential for revolutionizing health care by providing clinicians with data-driven insights that support more accurate and efficient clinical decisions. However, applying AI in clinical settings is often challenging due to the complexity and vastness of medical information. This perspective article explores how AI development methodologies can be adapted to support clinicians in their decision-making processes, emphasizing the importance of a hybrid approach that combines AI capabilities with clinicians' expertise.

Patients and methods: We developed a conceptual framework designed to integrate AI-driven hybrid intelligence into clinical practice to enhance decision-making. This framework focuses on adapting key AI concepts, such as backpropagation, quantization, and avoiding overfitting, to help clinicians better interpret complex medical data and improve diagnosis and treatment planning.

Results: Several AI methodologies were adapted to enhance clinical decision-making. First, backpropagation allows clinicians to refine initial assessments by revisiting them as new data emerges, improving diagnostic accuracy over time. Second, quantization helps break down complex medical problems into manageable components, enabling clinicians to prioritize critical elements of care. Finally, avoiding overfitting encourages clinicians to balance rare diagnoses with more common explanations, reducing the risk of diagnostic errors and unnecessary complexity.

Conclusion: The integration of AI-driven hybrid intelligence has the potential to enhance clinical decision-making. By adapting AI methodologies, clinicians can enhance their ability to analyze data, prioritize treatments, and make more accurate diagnoses while preserving the essential human aspect of health care. This framework highlights the importance of combining AI's strengths with clinicians' expertise for more effective and balanced decision-making in clinical practice. This perspective highlights the value of hybrid intelligence in achieving more balanced, effective, and patient-centered decision-making in health care.

目的:人工智能(AI)为临床医生提供数据驱动的洞察力,支持更准确、更高效的临床决策,从而为医疗保健带来巨大的变革潜力。然而,由于医疗信息的复杂性和庞大性,在临床环境中应用人工智能往往具有挑战性。本视角文章探讨了如何调整人工智能开发方法以支持临床医生的决策过程,强调了将人工智能能力与临床医生的专业知识相结合的混合方法的重要性:我们开发了一个概念框架,旨在将人工智能驱动的混合智能整合到临床实践中,以提高决策水平。该框架侧重于调整关键的人工智能概念,如反向传播、量化和避免过度拟合,以帮助临床医生更好地解释复杂的医疗数据,改进诊断和治疗计划:结果:我们对几种人工智能方法进行了调整,以提高临床决策能力。首先,反向传播允许临床医生在新数据出现时重新审视初步评估,从而改进诊断准确性。其次,量化有助于将复杂的医疗问题分解为易于管理的组成部分,使临床医生能够优先考虑关键的护理要素。最后,避免过度拟合可鼓励临床医生平衡罕见诊断与更常见的解释,从而降低诊断错误和不必要复杂性的风险:结论:人工智能驱动的混合智能的整合具有增强临床决策的潜力。通过调整人工智能方法,临床医生可以提高他们分析数据、确定治疗优先顺序和做出更准确诊断的能力,同时保留医疗保健中人的基本方面。这一框架强调了将人工智能的优势与临床医生的专业知识相结合,从而在临床实践中做出更有效、更平衡决策的重要性。这一观点强调了混合智能在实现更平衡、更有效和以患者为中心的医疗决策方面的价值。
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引用次数: 0
Diaphragmatic Dynamics Assessed by Bedside Ultrasound Predict Extubation in the Intensive Care Unit: A Prospective Observational Study. 床旁超声波评估的横膈膜动态可预测重症监护病房的拔管情况:一项前瞻性观察研究
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-18 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S487999
Tianjie Zhang, Yan Liu, Dongwei Xu, Rui Dong, Ye Song

Background: This study aims to evaluate the predictive value of bedside ultrasound evaluation of diaphragmatic dynamics in determining successful extubation outcomes for patients eligible for weaning.

Methods: This prospective observational study was conducted on patients who were mechanically ventilated and ready for weaning during the spontaneous breathing trial (SBT). The diaphragm contraction and motion-related parameters of patients such as end inspiratory diaphragm thickness (DT-insp), end respiratory diaphragm thickness (DT-exp), diaphragm thickening fraction (DTF), diaphragmatic thickening fraction rapid shallow breathing index (DTF-RSBI), diaphragmatic excursion (DE), diaphragmatic excursion rapid shallow breathing index (DE-RSBI) were recorded and the association with failure in ventilatory extubation was analyzed. A receiver operating characteristic (ROC) curve was conducted to analyze the prediction of successful weaning.

Results: Out of 95 patients, 14 (14.74%) died, and 68 (71.58%) were successfully extubated. There were significant differences between the two groups in all parameters except DT-exp. The results indicated that duration of mechanical ventilation (OR = 0.850, 95% CI: 0.770-0.938, P = 0.001), DTF (OR = 1.214, 95% CI: 1.108-1.330, P = 0.000), DTF-RSBI (OR = 0.917, 95% CI: 0.880-0.954, P = 0.000), DE (OR = 127.02, 95% CI: 15.004-1075.291, P = 0.000), DE-RSBI (OR = 0.752, 95% CI: 0.657-0.861, P = 0.000) had predictive value for weaning. DTF and DE had a high sensitivity of 91.18%, 100%, respectively. Whereas, duration of mechanical ventilation, DTF-RSBI, DE-RSBI showed a high specificity of 81.48,85.19%, 81.48%. Considering all the above factors, the sensitivity was 88.24% and the specificity was 88.89%.

Conclusion: Bedside ultrasound assessment of diaphragmatic parameters enables the detection of diaphragmatic dysfunction, thus proving valuable in predicting extubation success and facilitating a favorable weaning outcome.

背景:本研究旨在评估床旁超声评估膈肌动态对确定符合断奶条件的患者成功拔管的预测价值:本研究旨在评估床旁膈肌动态超声评估在确定符合断奶条件的患者成功拔管结果方面的预测价值:这项前瞻性观察研究的对象是在自主呼吸试验(SBT)期间接受机械通气并准备断气的患者。记录患者的膈肌收缩和运动相关参数,如吸气末膈肌厚度(DT-insp)、呼吸末膈肌厚度(DT-exp)、膈肌增厚分数(DTF)、膈肌增厚分数快速浅呼吸指数(DTF-RSBI)、膈肌偏移(DE)、膈肌偏移快速浅呼吸指数(DE-RSBI),并分析其与通气拔管失败的关系。采用接收者操作特征曲线(ROC)分析成功断奶的预测结果:在 95 名患者中,14 人(14.74%)死亡,68 人(71.58%)成功拔管。除 DT-exp 外,两组患者在所有参数上均存在明显差异。结果显示,机械通气持续时间(OR = 0.850,95% CI:0.770-0.938,P = 0.001)、DTF(OR = 1.214,95% CI:1.108-1.330,P = 0.000)、DTF-RSBI(OR = 0.917,95% CI:0.880-0.954,P = 0.000)、DE(OR = 127.02,95% CI:15.004-1075.291,P = 0.000)、DE-RSBI(OR = 0.752,95% CI:0.657-0.861,P = 0.000)对断奶有预测价值。DTF和DE的灵敏度分别为91.18%和100%。而机械通气持续时间、DTF-RSBI、DE-RSBI 的特异性分别为 81.48%、85.19% 和 81.48%。综合以上因素,敏感性为 88.24%,特异性为 88.89%:床旁超声评估膈肌参数可发现膈肌功能障碍,因此在预测拔管成功率和促进良好的断奶结果方面具有重要价值。
{"title":"Diaphragmatic Dynamics Assessed by Bedside Ultrasound Predict Extubation in the Intensive Care Unit: A Prospective Observational Study.","authors":"Tianjie Zhang, Yan Liu, Dongwei Xu, Rui Dong, Ye Song","doi":"10.2147/IJGM.S487999","DOIUrl":"10.2147/IJGM.S487999","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the predictive value of bedside ultrasound evaluation of diaphragmatic dynamics in determining successful extubation outcomes for patients eligible for weaning.</p><p><strong>Methods: </strong>This prospective observational study was conducted on patients who were mechanically ventilated and ready for weaning during the spontaneous breathing trial (SBT). The diaphragm contraction and motion-related parameters of patients such as end inspiratory diaphragm thickness (DT-insp), end respiratory diaphragm thickness (DT-exp), diaphragm thickening fraction (DTF), diaphragmatic thickening fraction rapid shallow breathing index (DTF-RSBI), diaphragmatic excursion (DE), diaphragmatic excursion rapid shallow breathing index (DE-RSBI) were recorded and the association with failure in ventilatory extubation was analyzed. A receiver operating characteristic (ROC) curve was conducted to analyze the prediction of successful weaning.</p><p><strong>Results: </strong>Out of 95 patients, 14 (14.74%) died, and 68 (71.58%) were successfully extubated. There were significant differences between the two groups in all parameters except DT-exp. The results indicated that duration of mechanical ventilation (OR = 0.850, 95% CI: 0.770-0.938, P = 0.001), DTF (OR = 1.214, 95% CI: 1.108-1.330, P = 0.000), DTF-RSBI (OR = 0.917, 95% CI: 0.880-0.954, P = 0.000), DE (OR = 127.02, 95% CI: 15.004-1075.291, P = 0.000), DE-RSBI (OR = 0.752, 95% CI: 0.657-0.861, P = 0.000) had predictive value for weaning. DTF and DE had a high sensitivity of 91.18%, 100%, respectively. Whereas, duration of mechanical ventilation, DTF-RSBI, DE-RSBI showed a high specificity of 81.48,85.19%, 81.48%. Considering all the above factors, the sensitivity was 88.24% and the specificity was 88.89%.</p><p><strong>Conclusion: </strong>Bedside ultrasound assessment of diaphragmatic parameters enables the detection of diaphragmatic dysfunction, thus proving valuable in predicting extubation success and facilitating a favorable weaning outcome.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5373-5380"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of Congenital Heart Defects in Perinatal Infants in Guangxi, China. 中国广西围产期婴儿先天性心脏缺陷的流行病学。
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-18 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S466195
Zhenren Peng, Jie Wei, Xiuning Huang, Biyan Chen, Lifang Liang, Baoying Feng, Pengshu Song, Jiajia He, Ting Que, Jingjue Lan, Jie Qin, Sheng He, Qiufen Wei

Purpose: To explore the changing trends in the prevalence and epidemiological characteristics of congenital heart defects (CHDs) in perinatal infants (PIs) in Guangxi, China.

Patients and methods: During 2016 and 2020, the Guangxi Birth Defects Monitoring Network (GXBDMN) monitored a total of 3627108 PIs in this study. The CHDs data for PIs can be obtained from the GXBDMN. The study analyzed the changing trends of total CHDs prevalence and each subtype of CHDs prevalence per year using prevalence-rate ratios (PRR). The correlation between characteristics (such as year, infant gender, maternal age, and quarter) and the prevalence of CHDs was also examined by the PRR.

Results: Between 2016 and 2020, 10817 PIs were diagnosed with CHDs, resulting in an overall CHDs prevalence of 29.82 [95% confidence intervals (CI): 29.26-30.38] per 10000 PIs. CHDs accounted for 24.50% of all types of BDs, making them the most common type of BDs. Atrial septal defect / patent foramen ovale (ASD/PFO), patent ductus arteriosus (PDA), ventricular septal defect (VSD), atrioventricular septal defect (AVSD), persistent left superior vena cava (PLSVC), and tetralogy of Fallot (TOF) were the 6 most common subtypes of CHDs. Together they accounted for 86.24% of all CHDs cases, with a total prevalence of 25.72 (95% CI: 25.20-26.24) per 10000 PIs. The study period saw a significant increase in the prevalence of CHDs (PRR = 1.300, 95% CI: 1.283-1.318), and the maternal age also played a significant role in this increase (PRR = 2.738, 95% CI: 2.428-3.087).

Conclusion: The prevalence of CHDs in Guangxi is rising and has an upward trend with maternal age. ASD/PFO, PDA, VSD, AVSD, PLSVC, and TOF were the top six subtypes of CHDs.

目的:探讨中国广西围产儿先天性心脏缺陷(CHD)患病率的变化趋势和流行病学特征:广西出生缺陷监测网(GXBDMN)在 2016 年至 2020 年期间共监测了 3627108 例 PI。PIs的CHDs数据可从广西出生缺陷监测网获得。研究采用患病率比(PRR)分析了每年总的冠心病患病率和各亚型冠心病患病率的变化趋势。研究还通过患病率比率分析了特征(如年份、婴儿性别、母亲年龄和季度)与先天性心脏病患病率之间的相关性:2016 年至 2020 年间,10817 名婴幼儿被诊断出患有先天性心脏病,每 10000 名婴幼儿的先天性心脏病总患病率为 29.82 [95% 置信区间 (CI):29.26-30.38]。心脏缺损占所有心脏缺损类型的 24.50%,是最常见的心脏缺损类型。房间隔缺损/卵圆孔未闭(ASD/PFO)、动脉导管未闭(PDA)、室间隔缺损(VSD)、房室间隔缺损(AVSD)、左上腔静脉持续存在(PLSVC)和法洛氏四联症(TOF)是 6 种最常见的先天性心脏病亚型。它们共占所有先天性心脏病病例的 86.24%,总发病率为 25.72(95% CI:25.20-26.24)/10000 人。在研究期间,先天性心脏病的患病率明显上升(PRR = 1.300,95% CI:1.283-1.318),产妇年龄也在患病率上升中扮演了重要角色(PRR = 2.738,95% CI:2.428-3.087):结论:广西新生儿先天性心脏病的患病率呈上升趋势,且随着孕产妇年龄的增长而呈上升趋势。ASD/PFO、PDA、VSD、AVSD、PLSVC和TOF是前六种亚型的先天性心脏病。
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引用次数: 0
Bioinformatics Analysis and Experimental Validation of Endoplasmic Reticulum Stress-Related Genes in Osteoporosis. 骨质疏松症中内质网应激相关基因的生物信息学分析和实验验证
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-18 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S486776
Yong Zheng, Yonggui Luo, Kuihan Tang

Background: Endoplasmic reticulum stress (ERS) is closely associated with Osteoporosis (OP). In order to explore the role of ERS related genes in OP and its molecular mechanism.

Methods: OP-related transcriptome data were retrieved from the Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was applied to screen OP-related genes. Differentially expressed ERS-related genes (DE-ERSGs) between OP and controls were identified by overlapping OP-related, differentially expressed genes (DEGs), and ERS-related genes. ERS-related genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to explore their functions. Receiver operating characteristic (ROC) curves assessed the diagnostic value of DE-ERSGs, and comparative toxicogenomics database (CTD) was used to predict targeting agents for key DE-ERSGs. Finally, biomarker expression was verified by real time quantitative polymerase chain reaction (RT-qPCR).

Results: A total of 10 DE-ERSGs were screened in OP patients. GO and KEGG analyses indicated their enrichment in Alcoholic liver disease, Endometrial cancer, and Glycerolipid metabolism. ROC curve analysis revealed that RPN2, FOXO3, ERGIC2, and MYO9A had significant diagnostic value, thus being identified as key DE-ERSGs. Moreover, the key DE-ERSGs-drug interaction network showed that some drugs such as bisphenol A, Cisplatin, Cyclosporine, and Valproic Acid might play roles by targeting key DE-ERSGs in OP. The expression validation analysis of key DE-ERSGs revealed that RPN2, ERGIC2, and MYO9A was significantly expressed in the GSE62402. Ultimately, The blood samples RT-qPCR verification results show that RPN2, ERGIC2, and MYO9A were significantly lower in OP samples compared to normal samples (p < 0.05), whereas there was no difference in the expression levels of FOXO3.

Conclusion: RPN2, FOXO3, ERGIC2 and MYO9A as the biomarkers associated with ERS in OP by bioinformatics analysis, which may provide new biological targets for clinical treatment.

背景:内质网应激(ERS)与骨质疏松症(OP)密切相关:内质网应激(ERS)与骨质疏松症(OP)密切相关。为了探索ERS相关基因在OP中的作用及其分子机制:方法:从基因表达总库(GEO)数据库中检索与 OP 相关的转录组数据。应用加权基因共表达网络分析(WGCNA)筛选 OP 相关基因。通过重叠 OP 相关基因、差异表达基因(DEGs)和 ERS 相关基因,确定 OP 和对照组之间的 ERS 相关差异表达基因(DE-ERSGs)。ERS相关基因。对基因本体(GO)和京都基因组百科全书(KEGG)进行了分析,以探索其功能。受体操作特征曲线(ROC)评估了 DE-ERSGs 的诊断价值,比较毒物基因组学数据库(CTD)用于预测关键 DE-ERSGs 的靶向药物。最后,通过实时定量聚合酶链反应(RT-qPCR)验证了生物标志物的表达:结果:共在 OP 患者中筛选出 10 个 DE-ERSG。GO和KEGG分析表明,它们在酒精性肝病、子宫内膜癌和甘油脂代谢中富集。ROC曲线分析显示,RPN2、FOXO3、ERGIC2和MYO9A具有显著的诊断价值,因此被确定为关键DE-ERSGs。此外,关键DE-ERSGs-药物相互作用网络显示,一些药物如双酚A、顺铂、环孢素和丙戊酸可能通过靶向OP中的关键DE-ERSGs发挥作用。关键 DE-ERSGs 的表达验证分析表明,RPN2、ERGIC2 和 MYO9A 在 GSE62402 中有显著表达。最终,血液样本 RT-qPCR 验证结果显示,与正常样本相比,RPN2、ERGIC2 和 MYO9A 在 OP 样本中的表达量明显降低(P < 0.05),而 FOXO3 的表达量则没有差异:结论:通过生物信息学分析,RPN2、FOXO3、ERGIC2和MYO9A是与OP ERS相关的生物标志物,它们可能为临床治疗提供新的生物学靶点。
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引用次数: 0
Association of Hemoglobin Decrement During Hospitalization with Prognosis of Aneurysmal Subarachnoid Hemorrhage and Mediation Effects of Cerebral Infarction and Pneumonia. 动脉瘤性蛛网膜下腔出血患者住院期间血红蛋白下降与预后的关系以及脑梗塞和肺炎的中介效应
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-18 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S478795
Xudong Che, Baixue Wu, Hongxia Zhang, Dengzhi Jiang, Wenqiao Fu, Zhaohui He

Background: Hemoglobin decrement is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and is associated with poor outcome. However, the mediating variables on the causal pathway between hemoglobin decrement and poor outcome in aSAH are not clear.

Methods: This is a single-center retrospective observational study containing all consecutive patients with aSAH admitted to our hospital between January 1, 2019, and June 30, 2022. Hemoglobin decrement was defined as the hemoglobin at admission minus the minimum hemoglobin during hospitalization. Calculation of cutoff value using ROC curve Youden index. The main exposure of interest was a hemoglobin decrement greater than the cutoff value. The primary outcome was poor outcome at 3 months (mRS 4-6).

Results: A total of 480 patients with aSAH were included in the study, 414 (71.1%) had a favorable and 66 (28.9%) had a poor outcome at 3 months. The cut-off value for calculating the degree of hemoglobin decrease using the ROC curve was 12.5 g/l. Hemoglobin decrement greater than the cutoff value was significantly associated with pneumonia (OR 3.12; 95% CI 1.78-5.57; p < 0.001), cerebral infarction (OR 3.06; 95% CI 1.80-5.30; p < 0.001), and poor prognosis (OR 2.88; 95% CI 1.44-5.92; p = 0.003) at 3 months. The mediation effect was significant for both pneumonia and cerebral infarction, with the average causal mediation effect (ACME) were 0.04 (95% CI 0.02-0.08; p < 0.05) and 0.05 (95% CI 0.02-0.08; p < 0.001), respectively.

Conclusion: Hemoglobin decrement during hospitalization was significantly associated with poor prognosis after aSAH, and the increased risk of cerebral infarction and pneumonia might mediate this effect. Avoiding hemoglobin decrement greater than 12.5g/l may improve the prognosis of patients with aSAH.

背景:血红蛋白下降是动脉瘤性蛛网膜下腔出血(aSAH)后常见的并发症,与不良预后有关。然而,血红蛋白下降与动脉瘤性蛛网膜下腔出血不良预后之间因果关系的中介变量尚不清楚:这是一项单中心回顾性观察研究,包含我院在2019年1月1日至2022年6月30日期间收治的所有连续性aSAH患者。血红蛋白下降定义为入院时的血红蛋白减去住院期间的最低血红蛋白。使用 ROC 曲线 Youden 指数计算截断值。血红蛋白下降大于临界值是主要的关注暴露。主要结果是 3 个月后的不良预后(mRS 4-6):研究共纳入了 480 名急性脑梗死患者,其中 414 人(71.1%)在 3 个月后预后良好,66 人(28.9%)预后不良。利用 ROC 曲线计算血红蛋白下降程度的临界值为 12.5 克/升。血红蛋白下降超过临界值与肺炎(OR 3.12;95% CI 1.78-5.57;p < 0.001)、脑梗塞(OR 3.06;95% CI 1.80-5.30;p < 0.001)和3个月时预后不良(OR 2.88;95% CI 1.44-5.92;p = 0.003)显著相关。肺炎和脑梗死的中介效应显著,平均因果中介效应(ACME)分别为0.04(95% CI 0.02-0.08;p < 0.05)和0.05(95% CI 0.02-0.08;p < 0.001):结论:住院期间血红蛋白下降与急性脑梗死后的不良预后显著相关,而脑梗死和肺炎风险的增加可能是这一效应的中介。避免血红蛋白下降超过12.5克/升可能会改善急性脑梗死患者的预后。
{"title":"Association of Hemoglobin Decrement During Hospitalization with Prognosis of Aneurysmal Subarachnoid Hemorrhage and Mediation Effects of Cerebral Infarction and Pneumonia.","authors":"Xudong Che, Baixue Wu, Hongxia Zhang, Dengzhi Jiang, Wenqiao Fu, Zhaohui He","doi":"10.2147/IJGM.S478795","DOIUrl":"10.2147/IJGM.S478795","url":null,"abstract":"<p><strong>Background: </strong>Hemoglobin decrement is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and is associated with poor outcome. However, the mediating variables on the causal pathway between hemoglobin decrement and poor outcome in aSAH are not clear.</p><p><strong>Methods: </strong>This is a single-center retrospective observational study containing all consecutive patients with aSAH admitted to our hospital between January 1, 2019, and June 30, 2022. Hemoglobin decrement was defined as the hemoglobin at admission minus the minimum hemoglobin during hospitalization. Calculation of cutoff value using ROC curve Youden index. The main exposure of interest was a hemoglobin decrement greater than the cutoff value. The primary outcome was poor outcome at 3 months (mRS 4-6).</p><p><strong>Results: </strong>A total of 480 patients with aSAH were included in the study, 414 (71.1%) had a favorable and 66 (28.9%) had a poor outcome at 3 months. The cut-off value for calculating the degree of hemoglobin decrease using the ROC curve was 12.5 g/l. Hemoglobin decrement greater than the cutoff value was significantly associated with pneumonia (OR 3.12; 95% CI 1.78-5.57; p < 0.001), cerebral infarction (OR 3.06; 95% CI 1.80-5.30; p < 0.001), and poor prognosis (OR 2.88; 95% CI 1.44-5.92; p = 0.003) at 3 months. The mediation effect was significant for both pneumonia and cerebral infarction, with the average causal mediation effect (ACME) were 0.04 (95% CI 0.02-0.08; p < 0.05) and 0.05 (95% CI 0.02-0.08; p < 0.001), respectively.</p><p><strong>Conclusion: </strong>Hemoglobin decrement during hospitalization was significantly associated with poor prognosis after aSAH, and the increased risk of cerebral infarction and pneumonia might mediate this effect. Avoiding hemoglobin decrement greater than 12.5g/l may improve the prognosis of patients with aSAH.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5349-5358"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interrelation of Blood Urea Nitrogen-to-Albumin Ratio with Three-Month Clinical Outcomes in Acute Ischemic Stroke Cases: A Secondary Analytical Exploration Derived from a Prospective Cohort Study. 急性缺血性脑卒中病例中血尿素氮与白蛋白比率与三个月临床结果的相互关系:一项前瞻性队列研究的二次分析探索
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-16 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S483505
Hongjuan Liu, Yanli Tang, Quan Zhou, Jing Zhang, Xin Li, Hui Gu, Bohong Hu, Yandeng Li

Objective: This study targeted elucidating the intricate correlation of the blood urea nitrogen (BUN)-to-albumin (BUN/Alb) ratio with adverse outcomes (AOs) at 3-month in acute ischemic stroke (AIS) cases within a Korean cohort.

Methods: The cohort involved a comprehensive dataset of 1850 AIS cases from a South Korean hospital, spanning from January 2010 to December 2016. To discern the linear relationship of the BUN/Alb ratio with AOs in AIS cases, utilization of a binary logistic regression model (BLRM) was implemented. Additionally, it was attempted to utilize sophisticated statistical techniques, such as generalized additive models (GAMs) and smooth curve fitting methods, to unravel the nonlinear association of the BUN/Alb ratio with AOs in such patients.

Results: The incidence of AOs was determined to be 28.49%, with the median BUN/Alb ratio being 3.85. After adjusting for a number of covariates, the BLRM disclosed that the linear association of BUN/Alb ratio with the risk of AOs particularly in AIS cases did not achieve statistical significance. However, a noticeable nonlinear relationship emerged, with an inflection point identified at 2.86. To the left of this inflection point, the relationship is not statistically significant. On the right side of the inflection point, there was a remarkable 9.47% rise in the risk of AOs (odds ratio (OR) = 1.09, 95% confidence interval (CI): 1.00, 1.19, P = 0.04).

Conclusion: The outcomes illuminate the complex and nonlinear relationship of the BUN/Alb ratio with 3-month AOs in AIS cases. This study established a robust groundwork for the future research, underscoring the potential clinical utility of monitoring the BUN/Alb ratio to enhance the prognostic assessment and management of AIS cases.

研究目的本研究旨在阐明韩国队列中急性缺血性卒中(AIS)病例的血尿素氮(BUN)-白蛋白(BUN/Alb)比值与3个月不良预后(AOs)之间错综复杂的相关性:该队列包含韩国一家医院 2010 年 1 月至 2016 年 12 月期间 1850 例 AIS 病例的综合数据集。为了确定 AIS 病例中 BUN/Alb 比率与 AOs 的线性关系,采用了二元逻辑回归模型 (BLRM)。此外,还尝试利用复杂的统计技术,如广义相加模型(GAMs)和平滑曲线拟合方法,来揭示这类患者的 BUN/Alb 比值与 AOs 的非线性关系:AOs 发生率为 28.49%,BUN/Alb 比率中位数为 3.85。在对一些协变量进行调整后,BLRM 显示,BUN/Alb 比值与 AOs 风险的线性关系,尤其是在 AIS 病例中,并没有达到统计学意义。不过,两者之间出现了明显的非线性关系,在 2.86 处出现了一个拐点。在该拐点的左侧,该关系在统计学上并不显著。在拐点的右侧,AO 风险显著上升了 9.47%(几率比(OR)= 1.09,95% 置信区间(CI):1.00,1.19,P = 0.04):研究结果阐明了 BUN/Alb 比值与 AIS 病例 3 个月 AOs 之间复杂的非线性关系。这项研究为今后的研究奠定了坚实的基础,强调了监测 BUN/Alb 比值对加强 AIS 病例预后评估和管理的潜在临床实用性。
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引用次数: 0
Neutrophil Lymphocyte Ratio Predicts Early Neurological Deterioration in Patients with Anterior Circulation Stroke. 中性粒细胞淋巴细胞比值可预测前循环卒中患者的早期神经功能衰退
IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-16 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S472316
Lingling Zhao, Shuyu Zhou, Qiliang Dai, Junrong Li

Background: Early neurologic deterioration (END) in acute ischemic stroke could result in significant worsening of clinical prognosis. Neutrophil lymphocyte ratio (NLR) is related to stroke severity and might be a predictor of short-term mortality in acute ischemic stroke. This study investigated the relationship between NLR and END in anterior circulation stroke patients.

Methods: Consecutive patients with first-ever acute ischemic stroke admitted to hospital within 24-hour of symptom onset were analyzed. NLR was calculated according to the Laboratory parameters obtained during the first 24 hours after admission. The rate of the END was recorded during the first 72-hours of admission. Multivariate logistic regression was applied to investigate the relationship between NLR and END.

Results: We included 228 consecutive patients within 24-hours of symptom onset for the final analysis. In total, 64 (28.1%) experienced END during the first 72 hours after admission. Patients with END were more likely to have higher NLR (median NLR 3.8 vs 2.4; p<0.001) compared with those without END. Multivariate logistic regression revealed that NLR>2.65 (OR, 4.019; 95% CI, 1.937-8.337; p<0.001) was an independent predictor of END. Also, patients in high NLR subgroup (NLR>2.65) at admission were more likely to have prolonged length of stays (median length of stays 12 vs 4; p<0.001).

Conclusion: This study found NLR was an independent predictor of END in patients with anterior circulation stroke.

背景:急性缺血性卒中的早期神经功能恶化(END)可导致临床预后显著恶化。中性粒细胞淋巴细胞比值(NLR)与卒中严重程度有关,可能是急性缺血性卒中短期死亡率的预测因子。本研究探讨了前循环卒中患者 NLR 与END 之间的关系:方法:对症状出现后 24 小时内入院的首次急性缺血性卒中患者进行分析。根据入院后 24 小时内获得的实验室参数计算 NLR。记录入院后 72 小时内的END发生率。多变量逻辑回归用于研究 NLR 和 END 之间的关系:我们纳入了 228 名症状出现后 24 小时内的连续患者进行最终分析。共有 64 人(28.1%)在入院后 72 小时内出现了END。END患者入院时NLR较高(中位数NLR为3.8 vs 2.4; p2.65 (OR, 4.019; 95% CI, 1.937-8.337; p2.65),住院时间较长(中位数住院时间为12 vs 4; p结论:本研究发现,NLR 是前循环卒中患者END 的独立预测因子。
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引用次数: 0
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International Journal of General Medicine
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