Pub Date : 2023-06-17DOI: 10.32553/ijmbs.v7i6.2711
Karthik K, Arathi Pillai, Anurodh Gupta, Palaniswamy Ramaswamy, Leena Rawat, Sibin M K
Background: Insulin resistance was associated with type-2 diabetes mellitus regardless of HIV status. However, an association of insulin resistance in prediabetes with HIV-infected subjects undergoing anti-retroviral therapy (ART) has been reported in very few studies. Methods: Serum insulin and insulin resistance (HOMA-IR) were measured in ART patients with impaired fasting glycemia (IFG) and those with normal glucose tolerance (NGT) along with other biochemical parameters. Results: There was increased insulin resistance in the ART IFG group when compared to their ART NGT counterparts. There was a positive correlation of HOMA-IR with serum creatinine, triglycerides, and ALT levels. However, serum HDL showed a negative correlation with HOMA-IR. Conclusion: Present study showed that there is association of insulin resistance in IFG associated with HIV-infected subjects on ART. Hence, monitoring the insulin resistance in ART patients may help in early prevention of type 2 diabetes mellitus. Keywords: Human Immunodeficiency Virus, anti-retroviral therapy, impaired fasting glycemia, serum Insulin, HOMA-IR
{"title":"Insulin Resistance Associated with Impaired Fasting Glycaemia in Anti-Retroviral Therapy Patients","authors":"Karthik K, Arathi Pillai, Anurodh Gupta, Palaniswamy Ramaswamy, Leena Rawat, Sibin M K","doi":"10.32553/ijmbs.v7i6.2711","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i6.2711","url":null,"abstract":"Background: Insulin resistance was associated with type-2 diabetes mellitus regardless of HIV status. However, an association of insulin resistance in prediabetes with HIV-infected subjects undergoing anti-retroviral therapy (ART) has been reported in very few studies. Methods: Serum insulin and insulin resistance (HOMA-IR) were measured in ART patients with impaired fasting glycemia (IFG) and those with normal glucose tolerance (NGT) along with other biochemical parameters. Results: There was increased insulin resistance in the ART IFG group when compared to their ART NGT counterparts. There was a positive correlation of HOMA-IR with serum creatinine, triglycerides, and ALT levels. However, serum HDL showed a negative correlation with HOMA-IR. Conclusion: Present study showed that there is association of insulin resistance in IFG associated with HIV-infected subjects on ART. Hence, monitoring the insulin resistance in ART patients may help in early prevention of type 2 diabetes mellitus. Keywords: Human Immunodeficiency Virus, anti-retroviral therapy, impaired fasting glycemia, serum Insulin, HOMA-IR","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135525255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-12DOI: 10.32553/ijmbs.v7i6.2713
Ritika Bhatia, Rakesh Goyal, Dilip Agarwal
Process validation is an integral part of pharmaceutical manufacturing, ensuring that tablets are consistently produced with quality and efficacy in line with regulatory requirements. The International Council for Harmonization ICH) provides guidelines for the systematic validation of manufacturing processes. This research article presents a comprehensive study on process validation for Paracetamol tablets following the ICH guidelines. The article focuses on various aspects of the validation process, including process design, qualification, and continued process verification, with specific emphasis on Paracetamol tablet manufacturing. Experimental studies were conducted to characterize the critical process parameters and assess their impact on the tablet's quality attributes. The article also discusses the use of statistical analysis techniques for data evaluation and demonstrates the establishment of a robust validation protocol for Paracetamol tablet manufacturing. Through the application of the ICH guidelines, this research contributes to ensuring the consistency and reliability of Paracetamol tablets, enhancing patient safety and meeting regulatory expectations.
Keywords: Process validation, ICH guidelines, Critical process parameters, Critical Process Attribution, Statistical analysis, and validation protocol;
{"title":"Process Validation of Paracetamol tablet as per ICH guidelines","authors":"Ritika Bhatia, Rakesh Goyal, Dilip Agarwal","doi":"10.32553/ijmbs.v7i6.2713","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i6.2713","url":null,"abstract":"Process validation is an integral part of pharmaceutical manufacturing, ensuring that tablets are consistently produced with quality and efficacy in line with regulatory requirements. The International Council for Harmonization ICH) provides guidelines for the systematic validation of manufacturing processes. This research article presents a comprehensive study on process validation for Paracetamol tablets following the ICH guidelines. The article focuses on various aspects of the validation process, including process design, qualification, and continued process verification, with specific emphasis on Paracetamol tablet manufacturing. Experimental studies were conducted to characterize the critical process parameters and assess their impact on the tablet's quality attributes. The article also discusses the use of statistical analysis techniques for data evaluation and demonstrates the establishment of a robust validation protocol for Paracetamol tablet manufacturing. Through the application of the ICH guidelines, this research contributes to ensuring the consistency and reliability of Paracetamol tablets, enhancing patient safety and meeting regulatory expectations.
 Keywords: Process validation, ICH guidelines, Critical process parameters, Critical Process Attribution, Statistical analysis, and validation protocol;","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136370206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This research paper aims to provide a comprehensive understanding of the process validation of Paracetamol tablets according to the guidelines outlined by the International Council for Harmonisation of Technical Requirements forPharmaceuticals for Human Use (ICH). Paracetamol is a widely used analgesic and antipyretic drug, and ensuring the quality, safety, and efficacy of its dosage form is of utmost importance. This study encompasses the three stages of process validation, namely process design, process qualification, and continued process verification, with a focus oncritical parameters and attributes. The article also explores the role of regulatory guidelines, such as the ICH Q8 (R2), Q9,and Q10, in facilitating effective process validation. (1)
Key words: Process Validation, ICH, CPP, CQA, SPC, Change Control, VMP;
{"title":"Process Validation of Paracetamol Tablets: A Comprehensive Study Based on ICH Guidelines","authors":"Ritika Bhatia, Mo. Firoj Tanwar, Rakesh Goyal, Dilip Agarwal","doi":"10.32553/ijmbs.v7i6.2712","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i6.2712","url":null,"abstract":"This research paper aims to provide a comprehensive understanding of the process validation of Paracetamol tablets according to the guidelines outlined by the International Council for Harmonisation of Technical Requirements forPharmaceuticals for Human Use (ICH). Paracetamol is a widely used analgesic and antipyretic drug, and ensuring the quality, safety, and efficacy of its dosage form is of utmost importance. This study encompasses the three stages of process validation, namely process design, process qualification, and continued process verification, with a focus oncritical parameters and attributes. The article also explores the role of regulatory guidelines, such as the ICH Q8 (R2), Q9,and Q10, in facilitating effective process validation. (1)
 Key words: Process Validation, ICH, CPP, CQA, SPC, Change Control, VMP;","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136370207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-19DOI: 10.32553/ijmbs.v7i5.2708
Dr. Kamlesh Yadav, Dr. Ritu Choudhary, Dr. Preeti Kumari, Dr. Rakesh Kumar Serawat, Dr. Panki Kumari
Introduction: Oligohydramnios is described as a condition with decreased amniotic fluid volume relative to gestational age. Oligohydramnios is most commonly defined as an amniotic fluid index (AFI) ? 5 cm or the largest vertical pocket measuring ? 2 cm. Isolated oligohydramnios (IO) refers to the presence of oligohydramnios without fetal structural and chromosomal abnormalities, without fetal growth restriction, without intrauterine infection and in the absence of known maternal disease. Aim: To study was to analyse the maternal and fetal outcome in isolated oligohydramnios in third trimester of pregnancy. Method: This is prospective hospital based observational study which was carried out in department of obstetrics and gynaecology, S.P. Medical College, Bikaner for a period from June 2021 to May 2022. This study included 100 pregnant women, who fulfill inclusion and exclusion criteria, out of which 50 pregnant women with 28 completed weeks of gestation who had singleton pregnancy with cephalic presentation and Amniotic Fluid Index (AFI) < 5 cm enrolled as study cases while 50 pregnant women with AFI > 5 cm were in control group. Results: Majority of the patients were in 21-30 years of age in both groups. Majority of patients in both groups were illiterate, unbooked, belonged to rural area and were from lower middle socioeconomic status; hence both groups were comparable in this regards. In our study in group A out of 50 patients, 33 (66%) had LSCS and 17 (34%) patients delivered by vaginal route and group B out of 50 patients, 43 (86%) patients delivered by vaginal route and only 7 (14%) patients had for LSCS. NICU admission in group A was 14 (28%) and in group B 3(6%) respectively. Conclusion: C-Section rates were more common in group A compared to group B. NICU admission rate were more in group A (40%) compare to group B (14%). In Isolated oligohydramnios more babies had APGAR<7 at 1& 5min.
{"title":"To Assess the Maternal and Perinatal Outcome with Isolated Oligohydramnios in Third Trimester of Pregnancy","authors":"Dr. Kamlesh Yadav, Dr. Ritu Choudhary, Dr. Preeti Kumari, Dr. Rakesh Kumar Serawat, Dr. Panki Kumari","doi":"10.32553/ijmbs.v7i5.2708","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i5.2708","url":null,"abstract":"Introduction: Oligohydramnios is described as a condition with decreased amniotic fluid volume relative to gestational age. Oligohydramnios is most commonly defined as an amniotic fluid index (AFI) ? 5 cm or the largest vertical pocket measuring ? 2 cm. Isolated oligohydramnios (IO) refers to the presence of oligohydramnios without fetal structural and chromosomal abnormalities, without fetal growth restriction, without intrauterine infection and in the absence of known maternal disease.\u0000Aim: To study was to analyse the maternal and fetal outcome in isolated oligohydramnios in third trimester of pregnancy.\u0000Method: This is prospective hospital based observational study which was carried out in department of obstetrics and gynaecology, S.P. Medical College, Bikaner for a period from June 2021 to May 2022. This study included 100 pregnant women, who fulfill inclusion and exclusion criteria, out of which 50 pregnant women with 28 completed weeks of gestation who had singleton pregnancy with cephalic presentation and Amniotic Fluid Index (AFI) < 5 cm enrolled as study cases while 50 pregnant women with AFI > 5 cm were in control group.\u0000Results: Majority of the patients were in 21-30 years of age in both groups. Majority of patients in both groups were illiterate, unbooked, belonged to rural area and were from lower middle socioeconomic status; hence both groups were comparable in this regards. In our study in group A out of 50 patients, 33 (66%) had LSCS and 17 (34%) patients delivered by vaginal route and group B out of 50 patients, 43 (86%) patients delivered by vaginal route and only 7 (14%) patients had for LSCS. NICU admission in group A was 14 (28%) and in group B 3(6%) respectively.\u0000Conclusion: C-Section rates were more common in group A compared to group B. NICU admission rate were more in group A (40%) compare to group B (14%). In Isolated oligohydramnios more babies had APGAR<7 at 1& 5min.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84923257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-19DOI: 10.32553/ijmbs.v7i5.2709
Dr. Kamlesh Yadav, Dr. Panki Kumari, Dr. Ritu Choudhary, Dr Priti Kumari
Background To evaluated various gynaecological problems among adolescent girls attending gynaecology out patient department at tertiary care hospital in Western Rajasthan Methods Hospital Based cross sectional study conducted on 138 adolescent girls. Study population will consist of all unmarried Adolescent girl’s age 10-19 yrs. attending outpatient department of obstetrics and Gynaecology Sardar Patel medical college Bikaner. Inclusion criteria All the unmarried adolescent female with age 10-19 yrs. Who come to Gynae OPD with any gynaecological complaint and willing to participants? Exclusion criteria Those not willing to participate and not given consent. Age less than <10 years and more than >19 years.
{"title":"Evaluation of Gynaecological Problems among Adolescent Girls attending Gynaecology out Patient Department at Tertiary Care Hospital in Western Rajasthan","authors":"Dr. Kamlesh Yadav, Dr. Panki Kumari, Dr. Ritu Choudhary, Dr Priti Kumari","doi":"10.32553/ijmbs.v7i5.2709","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i5.2709","url":null,"abstract":"Background\u0000To evaluated various gynaecological problems among adolescent girls attending gynaecology out patient department at tertiary care hospital in Western Rajasthan\u0000Methods\u0000Hospital Based cross sectional study conducted on 138 adolescent girls. Study population will consist of all unmarried Adolescent girl’s age 10-19 yrs. attending outpatient department of obstetrics and Gynaecology Sardar Patel medical college Bikaner.\u0000Inclusion criteria\u0000All the unmarried adolescent female with age 10-19 yrs. Who come to Gynae OPD with any gynaecological complaint and willing to participants?\u0000Exclusion criteria\u0000Those not willing to participate and not given consent.\u0000Age less than <10 years and more than >19 years.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80033271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-11DOI: 10.32553/ijmbs.v7i5.2705
Puspita Rahardjo Putri, E. Lodra
Introduction: Canine fossa abscess is an odontogenic infection originating from the upper jaw teeth, specifically from the premolar or canine. This abscess needs to be treated properly because it can be life-threatening. Canine fossa abscess that induces the formation of bullae is rare. Case Report: A 55-year-old male complained of a lump under his eye that contain clear fluid after previously undergoing abscess drainage through intraoral access and teeth extraction that caused the canine fossa abscess. The lump was in the form of a ruptured bullae lesion and reappeared. The treatment performed was incision through extraoral access, postoperative bandage, and antibiotic medication. The result showed that the bullae disappeared. The prognosis, in this case, is ad bonam. Conclusion: Canine fossa abscess cases can be life-threatening. Complications that arise, such as bullae, are rare but it is important to know the causes, treatment, and management. It is crucial for dentists to be aware so that they can determine the treatment when such cases occur. Keywords: Fossa Canine Abscess, Drainage, Bullae
{"title":"Canine Fossa Abscess-Induced Bullae Formation: A Case Report","authors":"Puspita Rahardjo Putri, E. Lodra","doi":"10.32553/ijmbs.v7i5.2705","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i5.2705","url":null,"abstract":"Introduction: Canine fossa abscess is an odontogenic infection originating from the upper jaw teeth, specifically from the premolar or canine. This abscess needs to be treated properly because it can be life-threatening. Canine fossa abscess that induces the formation of bullae is rare.\u0000Case Report: A 55-year-old male complained of a lump under his eye that contain clear fluid after previously undergoing abscess drainage through intraoral access and teeth extraction that caused the canine fossa abscess. The lump was in the form of a ruptured bullae lesion and reappeared. The treatment performed was incision through extraoral access, postoperative bandage, and antibiotic medication. The result showed that the bullae disappeared. The prognosis, in this case, is ad bonam.\u0000Conclusion: Canine fossa abscess cases can be life-threatening. Complications that arise, such as bullae, are rare but it is important to know the causes, treatment, and management. It is crucial for dentists to be aware so that they can determine the treatment when such cases occur.\u0000Keywords: Fossa Canine Abscess, Drainage, Bullae","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82843583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-06DOI: 10.32553/ijmbs.v7i5.2706
Dr. Rupesh Choudhary, Dr. Rahul Sharma, Dr. Ankita Jamwal, Dr. Divya Drishti
Background: Spinal block is the first choice for lower abdominal surgeries. Bupivacaine is the most common local anaesthetic used but has a shorter duration of action. Many adjuvants have been used to improve the quality of analgesia till postoperative period. In this study, we used ?2-agonists. Methods: A prospective randomized single blind study was conducted in the Department of Anaesthesia IGMC SHIMLA at Kamla Nehru state hospital. Results: Injection PCM 1gm was used as rescue analgesic if VAS ?4 was achieved in any patient. In Group C 10 patients received Inj PCM as compared to 8 patients in Group D. One patient in each group received 1 dose, 5 in Group C and 2 in Group D received 2 doses and 4 in Group C and 5 in Group D received 3 doses of Inj PCM in 24 hrs postoperative period. (p=0.693). Conclusion: We concluded that the rescue Analgesia used in post operative period.
{"title":"To Compare the Rescue Analgesia used in Post-Operative Period of Dexmedetomidine and Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Total Abdominal Hysterectomy","authors":"Dr. Rupesh Choudhary, Dr. Rahul Sharma, Dr. Ankita Jamwal, Dr. Divya Drishti","doi":"10.32553/ijmbs.v7i5.2706","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i5.2706","url":null,"abstract":"Background: Spinal block is the first choice for lower abdominal surgeries. Bupivacaine is the most common local anaesthetic used but has a shorter duration of action. Many adjuvants have been used to improve the quality of analgesia till postoperative period. In this study, we used ?2-agonists. \u0000Methods: A prospective randomized single blind study was conducted in the Department of Anaesthesia IGMC SHIMLA at Kamla Nehru state hospital. \u0000Results: Injection PCM 1gm was used as rescue analgesic if VAS ?4 was achieved in any patient. In Group C 10 patients received Inj PCM as compared to 8 patients in Group D. One patient in each group received 1 dose, 5 in Group C and 2 in Group D received 2 doses and 4 in Group C and 5 in Group D received 3 doses of Inj PCM in 24 hrs postoperative period. (p=0.693). \u0000Conclusion: We concluded that the rescue Analgesia used in post operative period.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87304278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-06DOI: 10.32553/ijmbs.v7i5.2707
Dr. Rupesh Choudhary, Dr. Rahul Sharma, Dr. Ankita Jamwal, Dr. Divya Drishti
Background: Addition of adjuvants to routinely used intrathecal drugs is cornerstone in safe and effective prolongation of single shot spinal block for gynecological surgery. In resource deficient countries, where epidural anaesthesia is usually not used because of cost factor, adjuvants are routinely used to prolong the effect of regional anaesthesia. Alpha 2 agonists are considered best drugs as adjuvants, but there is inconclusive data in literature about the block characteristic, dose at which to be used and side effect after use of these drugs. Methods: A prospective randomized single blind study was conducted in the Department of Anaesthesia IGMC SHIMLA at Kamla Nehru state hospital. Results: Hypotension was seen in 5 patients of Group C and 4 patients of Group D. Three patients in both the groups required 2 doses of Inj mephenteramine and 2 patients in Group C and 1 in Group D required single dose of Vasopressor (Inj mephentermine). (p=0.83). Five patients had bradycardia, 3 Nausea and 3 had shivering in Group C, while only 2 patients had side effects in Group D i.e one patient had bradycardia and another nausea, vomiting. (p= 0.657) Conclusion: We observed hypotension, bradycardia, nausea vomiting and post operative shivering in our patients during the study period but there was no statistical significance achieved amongst the groups. (p>0.05).
{"title":"To Compare the Side Effect of Dexmedetomidine and Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Total Abdominal Hysterectomy","authors":"Dr. Rupesh Choudhary, Dr. Rahul Sharma, Dr. Ankita Jamwal, Dr. Divya Drishti","doi":"10.32553/ijmbs.v7i5.2707","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i5.2707","url":null,"abstract":"Background: Addition of adjuvants to routinely used intrathecal drugs is cornerstone in safe and effective prolongation of single shot spinal block for gynecological surgery. In resource deficient countries, where epidural anaesthesia is usually not used because of cost factor, adjuvants are routinely used to prolong the effect of regional anaesthesia. Alpha 2 agonists are considered best drugs as adjuvants, but there is inconclusive data in literature about the block characteristic, dose at which to be used and side effect after use of these drugs. \u0000Methods: A prospective randomized single blind study was conducted in the Department of Anaesthesia IGMC SHIMLA at Kamla Nehru state hospital. \u0000Results: Hypotension was seen in 5 patients of Group C and 4 patients of Group D. Three patients in both the groups required 2 doses of Inj mephenteramine and 2 patients in Group C and 1 in Group D required single dose of Vasopressor (Inj mephentermine). (p=0.83). Five patients had bradycardia, 3 Nausea and 3 had shivering in Group C, while only 2 patients had side effects in Group D i.e one patient had bradycardia and another nausea, vomiting. (p= 0.657) \u0000Conclusion: We observed hypotension, bradycardia, nausea vomiting and post operative shivering in our patients during the study period but there was no statistical significance achieved amongst the groups. (p>0.05). ","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91493046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-05DOI: 10.32553/ijmbs.v7i4.2699
Dhruvi Joshi, Dhruvi Joshi, Dr. Moolchand Khichad, Dr.Abhishek Mittal, D. Joshi
Abstract Objective: To Compare the safety and efficacy between intravenous iron sucrose and ferric carboxy maltose in the treatment of iron deficiency anemia in pregnancy. Methodology: A Prospective study was conducted on 100 antenatal women with iron deficiency anemia in department of Obstetrics and Gynecology of a tertiary care center in northern India from June 2021 to May 2022. Results: The mean age in group A (Iron Sucrose group) was 25+ 2.83 years and in group B (FCM group) was 24.08+4.45 years. In group A (IS group) the average increase in Hb level was about 1.24 ± 0.29 gm/dl at 3 weeks and 2.62 ± 0.2 gm/dl at 6 weeks. In group B (FCM group) the average increase was about 1.74 ± 0.42 gm/dl at 3 weeks and 4.15 ± 1.94 gm/dl at 6 weeks. In IS group the average increase in ferritin was about 18.83 ± 18.18 ng/dl at 3 weeks and 43.54 ± 31.71 ng/dl at 6 weeks. In FCM group the average increase was about 34 ± 19.83 ng/dl at 3 weeks and 96.62 ± 50.7 ng/dl at 6 weeks. P value at both time periods was 0.0001, which is highly significant. 43 patients (86%) in Group B as compared to 19 patients (38%) in group A showed improvement in anaemia in PBS findings over 3 week and 6 week period, which was statistically significant with a P value of 0.024. In Group A (IS group ) only two patients complained of diarrhoea, two complained of headache, 1 patient complained of nausea ,vomiting, one complained of nausea only, In Group B (FCM group) total 3 patients (6%) complained of minor reactions like nausea, vomiting and itching. There were mild side effects only in both the groups. Conclusion: Intravenous FCM is more efficient and better alternative than iron sucrose in the treatment of iron deficiency anaemia in pregnancy. Key Words: IDA, FCM, IS, Ferritin, Haemoglobin.
{"title":"A Comparative Study to Assess the Safety and Efficacy between Intravenous Iron Sucrose and Ferric Carboxymaltose in the Treatment of Iron Deficiency Anemia in Pregnancy – A Single Center Prospective Observational Study from a Tertiary Care Center.","authors":"Dhruvi Joshi, Dhruvi Joshi, Dr. Moolchand Khichad, Dr.Abhishek Mittal, D. Joshi","doi":"10.32553/ijmbs.v7i4.2699","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2699","url":null,"abstract":"Abstract\u0000Objective: To Compare the safety and efficacy between intravenous iron sucrose and ferric carboxy maltose in the treatment of iron deficiency anemia in pregnancy.\u0000Methodology: A Prospective study was conducted on 100 antenatal women with iron deficiency anemia in department of Obstetrics and Gynecology of a tertiary care center in northern India from June 2021 to May 2022.\u0000Results: The mean age in group A (Iron Sucrose group) was 25+ 2.83 years and in group B (FCM group) was 24.08+4.45 years. In group A (IS group) the average increase in Hb level was about 1.24 ± 0.29 gm/dl at 3 weeks and 2.62 ± 0.2 gm/dl at 6 weeks. In group B (FCM group) the average increase was about 1.74 ± 0.42 gm/dl at 3 weeks and 4.15 ± 1.94 gm/dl at 6 weeks. In IS group the average increase in ferritin was about 18.83 ± 18.18 ng/dl at 3 weeks and 43.54 ± 31.71 ng/dl at 6 weeks. In FCM group the average increase was about 34 ± 19.83 ng/dl at 3 weeks and 96.62 ± 50.7 ng/dl at 6 weeks. P value at both time periods was 0.0001, which is highly significant. 43 patients (86%) in Group B as compared to 19 patients (38%) in group A showed improvement in anaemia in PBS findings over 3 week and 6 week period, which was statistically significant with a P value of 0.024. In Group A (IS group ) only two patients complained of diarrhoea, two complained of headache, 1 patient complained of nausea ,vomiting, one complained of nausea only, In Group B (FCM group) total 3 patients (6%) complained of minor reactions like nausea, vomiting and itching. There were mild side effects only in both the groups.\u0000Conclusion: Intravenous FCM is more efficient and better alternative than iron sucrose in the treatment of iron deficiency anaemia in pregnancy.\u0000Key Words: IDA, FCM, IS, Ferritin, Haemoglobin.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86170628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-02DOI: 10.32553/ijmbs.v7i4.2698
S. P, Alagarsamy V, Subhash Chandra Bose P., S. V, Saritha D
Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Rimantadine is one of the effective anti-viral drugs that is used in treating influenza virus. In present study niosomes of Rimantadine were developed by ether injection method. Total 6 formulations were prepared by altering ratios of span 60 and cholesterol. The prepared formulations were evaluated for different parameters. In vitro drug release studies were carried out for all the formulations and among five formulations F5 was found to have highest drug release. Prepared niosomes were incorporated in gel and evaluation studies like pH, homogenicity, viscosity and spreadability were carried out. All the parameters were found satisfactory. It was compared with marketed gel. The former has shown drug release till 12 h whereas the latter has shown only till 6 h. Thus, sustained release of drug loaded niosomes was proved.
{"title":"Fabrication and Evaluation of Rimantadine Loaded Niosomes","authors":"S. P, Alagarsamy V, Subhash Chandra Bose P., S. V, Saritha D","doi":"10.32553/ijmbs.v7i4.2698","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2698","url":null,"abstract":"Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Rimantadine is one of the effective anti-viral drugs that is used in treating influenza virus. In present study niosomes of Rimantadine were developed by ether injection method. Total 6 formulations were prepared by altering ratios of span 60 and cholesterol. The prepared formulations were evaluated for different parameters. In vitro drug release studies were carried out for all the formulations and among five formulations F5 was found to have highest drug release. Prepared niosomes were incorporated in gel and evaluation studies like pH, homogenicity, viscosity and spreadability were carried out. All the parameters were found satisfactory. It was compared with marketed gel. The former has shown drug release till 12 h whereas the latter has shown only till 6 h. Thus, sustained release of drug loaded niosomes was proved.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74067506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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