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Review on Gastroprotective Effect of Herbal Medicines 草药的胃保护作用综述
Pub Date : 2023-12-02 DOI: 10.32553/ijmbs.v6i11.2747
Sakshi Soni, Vishal Verma, Udichi Kataria
Herbal medicines are very important to cure the various ailments of human. Demands of the herbal medicines are increasing in both developed and under developed countries due to growing recognition of natural plants being lesser of side effect, easily available in surrounding place with low coast. Despite extensive research, the etiology ofpeptic ulcer disease remains unclear. Given the multiple processes that control acid and pepsin secretion and defense and repair of the gastroduodenal mucosa, it is likely that the cause of ulceration differs between individuals. Acid and pepsin appear to be necessary but not sufficient ingredients in the ulcerative process.. NSAIDs cause a significant number of gastric and duodenal ulcers; this is probably due to inhibition of prostaglandin production with loss of its protectiveeffects. In the absence of NSAIDs and gastrinoma, it appears that most gastric ulcers and all duodenal ulcers occur in the setting of H. pylori infection. Gastric ulcer often occurs with decreased acid-peptic activity, suggesting that mucosaldefensive impairments are more important. The combination of inflammation, protective deficiencies, and moderate amounts of acid and pepsin may be enough to induce ulceration. Many questions remain in understanding the pathophysiology of peptic ulcer disease. The physiology and pathophysiology of mucosal regeneration and the mechanisms by which H. pylori and inflammation disrupt normal gastroduodenal function will be fruitful areas of future investigation. In this review attempts have been made to know the antiulcer drug of natural origin with their suggestedmedicinal part. Key Words: Peptic ulcer , H.pylori , Herbal Medicines ,NSAID’s
草药对治疗人类的各种疾病非常重要。由于越来越多的人认识到天然植物的副作用更小,在周围低海岸的地方很容易获得,因此发达国家和欠发达国家对草药的需求都在增加。尽管广泛的研究,消化性溃疡的病因仍不清楚。考虑到胃十二指肠黏膜的酸和胃蛋白酶分泌以及防御和修复的多个过程,溃疡的原因可能因人而异。酸和胃蛋白酶似乎是必要的,但不是充分的成分在溃疡的过程。非甾体抗炎药引起大量胃溃疡和十二指肠溃疡;这可能是由于前列腺素的产生受到抑制而失去了保护作用。在没有非甾体抗炎药和胃原质瘤的情况下,大多数胃溃疡和所有十二指肠溃疡似乎都发生在幽门螺杆菌感染的情况下。胃溃疡的发生常伴有胃酸消化酶活性降低,提示粘膜防御功能受损更为重要。炎症、保护性缺陷、适量酸和胃蛋白酶的结合可能足以诱发溃疡。在了解消化性溃疡的病理生理方面仍有许多问题。粘膜再生的生理和病理生理以及幽门螺杆菌和炎症破坏正常胃十二指肠功能的机制将是未来研究的重要领域。本文试图了解天然来源的抗溃疡药物及其建议的药用成分。关键词:消化性溃疡,幽门螺杆菌,草药,非甾体抗炎药
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引用次数: 0
Management of Exposed plate of mandibular fracture: A Case Report 下颌骨骨折钢板外露的处理:病例报告
Pub Date : 2023-12-01 DOI: 10.32553/ijmbs.v7i11.2742
George Abraham Saragih, A. Yuza, Winarno Priyanto
Mandibular reconstruction is a trauma management to achieve good occlusal. Mandibular reconstruction plates are one of the post-ORIF reconstruction procedures that are often used at Hasan Sadikin Hospital. This article aims to determine how the management of plate exposure in mandibular fracture cases must be appropriate and according to indications for the administration. Cases of oblique area fractures that extend to the body of the mandible should be reduced and repositioned through an extra oral opening. Apart from that, modifications are needed in reconstructing cases where the mandibular bone is left thin by installing a mini plate at the champs line and mandibular margin. By modifying the attachment of the miniplate, it is hoped that the mandible will be more stable and function normally. It is hoped that the risk of plate exposure in patients can be minimized through appropriate management.
下颌骨重建是一种创伤处理方法,可达到良好的咬合效果。下颌重建钢板是哈桑·萨迪金医院常用的orif术后重建手术之一。本文旨在确定如何处理下颌骨骨折病例的钢板暴露必须是适当的,并根据给药指征。斜区骨折延伸至下颌骨的病例应复位并通过口外开口重新定位。除此之外,在重建下颌骨较薄的情况下,需要在下颌弓线和下颌骨边缘安装一个微型钢板。通过修改微型钢板的附着体,希望下颌骨更加稳定,功能正常。希望通过适当的管理可以将患者钢板暴露的风险降至最低。
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引用次数: 0
Relationship between total free Sugars Consumption and Incidence of Laryngopharyngeal Reflux in Adolescents 青少年游离糖总摄入量与喉咽反流发病率之间的关系
Pub Date : 2023-11-30 DOI: 10.32553/ijmbs.v7i11.2745
Audy Apriliani, Yenny
Background: Up to date there are still few studies showing the relationship between laryngopharyngeal reflux (LPR) and free sugars consumption in adolescents. We consequently aimed to discover any association of free sugars consumption with LPR in Indonesian adolescents. Methods: This cross-sectional study was conducted on 210 middle school students in Jakarta, Indonesia.  Data on age and gender were collected using a questionnaire, while body mass index was determined by anthropometric measurement. Free sugars consumption and LPR were evaluated by means of Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) and Reflux Symptom Index (RSI), respectively. Data were analyzed using Mann-Whitney test at level of significance p <0.05. Results: Median age (min - max) was 16 (15 – 18) years, body mass index 19.8 (15.4 – 27.0) kg/m2, and free sugars consumption 6.7 (1.5 – 70.6) g/day. The prevalence of LPR was 14.3%. There was a statistically significant difference in free sugars consumption of the LPR negative versus the LPR positive groups (p< 0.049). Conclusion: Free sugars consumption was strongly related to laryngopharyngeal reflux incidence. There is a need for a policy on and monitoring of free sugars consumption to decrease its harmful impact on adolescent health. Keywords: free sugars, laryngopharyngeal reflux, adolescents, Indonesia
背景:迄今为止,显示青少年喉咽反流(LPR)与食用游离糖之间关系的研究仍然很少。因此,我们旨在发现印度尼西亚青少年食用游离糖与 LPR 之间的关系。研究方法这项横断面研究的对象是印度尼西亚雅加达的 210 名中学生。 通过问卷调查收集了有关年龄和性别的数据,并通过人体测量测定了体重指数。通过半定量食物频率问卷(SQ-FFQ)和反流症状指数(RSI)分别对游离糖摄入量和 LPR 进行了评估。数据采用 Mann-Whitney 检验进行分析,显著性水平为 P <0.05。结果中位年龄(最小 - 最大)为 16(15 - 18)岁,体重指数为 19.8(15.4 - 27.0)千克/平方米,游离糖摄入量为 6.7(1.5 - 70.6)克/天。LPR 患病率为 14.3%。LPR 阴性组与 LPR 阳性组的游离糖摄入量在统计学上有显著差异(p< 0.049)。结论:游离糖的摄入量与喉咽反流的发生率密切相关。有必要制定有关食用游离糖的政策并对其进行监测,以减少游离糖对青少年健康的有害影响。关键词:游离糖、喉咽反流、青少年、印度尼西亚
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引用次数: 0
Clinicopathological Study of Lesions of Upper Gastrointestinal Tract 上消化道病变的临床病理学研究
Pub Date : 2023-11-17 DOI: 10.32553/ijmbs.v7i10.2743
Neha Sharma
62 sections of the GIT tract were used in this study. It was possible to get biopsies from the esophagus, mouth, stomach, duodenum, liver, small intestine, colon, rectum, and anal canal. Most of the specimens came from people aged 21 to 30 (24), then from people aged 11 to 20 (16), 31 to 40 (10), 41 to 50 (8), and older than 50 (4). There were 50 tumors that were not cancerous and 12 that were. Most of the non-cancerous tumors were found in the gall bladder, then the stomach, and finally the small intestine. The gall bladder was the organ most often affected by cancerous tumors (5), followed by the stomach. Chronic inflammatory lesions of the esophagus were seen in 10, appendicular lesions were seen in 3, gall bladder lesions were seen in 26, intestinal perforation was seen in 4, Crohn's disease of the small intestine was seen in 5, and peptic ulcers were seen in 2. Three of the cases had SCC of the esophagus, one had adenocarcinoma of the small intestine, one had adenocarcinoma of the large intestine, two had SCC of the stomach, and five had adenoma of the gall bladder. The authors found that most of the non-cancerous tumors were in the gall bladder and were found in people aged 21 to 30. Keywords: Gastrointestinal tract, neoplastic lesions, Gall bladder.
这项研究使用了 62 个消化道切片。可以从食道、口腔、胃、十二指肠、肝脏、小肠、结肠、直肠和肛管获取活组织切片。大部分标本来自 21 至 30 岁的人群(24 例),然后是 11 至 20 岁(16 例)、31 至 40 岁(10 例)、41 至 50 岁(8 例)和 50 岁以上(4 例)的人群。有 50 个肿瘤不是癌症,12 个是癌症。大多数非癌症肿瘤位于胆囊,然后是胃,最后是小肠。胆囊是最常受癌症肿瘤影响的器官(5 例),其次是胃。食道慢性炎症病变 10 例,阑尾病变 3 例,胆囊病变 26 例,肠穿孔 4 例,小肠克罗恩病 5 例,消化性溃疡 2 例。其中 3 例为食管 SCC,1 例为小肠腺癌,1 例为大肠腺癌,2 例为胃 SCC,5 例为胆囊腺瘤。作者发现,大多数非癌症肿瘤位于胆囊,发现者年龄在 21 岁至 30 岁之间。 关键词:胃肠道胃肠道 肿瘤性病变 胆囊
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引用次数: 0
Management of Maxillofacial Soft Tissue Trauma with Parotid Gland Exposure: Case Report 颌面部软组织创伤伴腮腺外露1例
Pub Date : 2023-10-24 DOI: 10.32553/ijmbs.v7i10.2739
George Abraham Saragih, Seto Adiantoro Sadputranto, Indra Hadikrishna
Introduction: Soft tissue trauma in Oral and Maxillofacial cases occurs quite often in the Emergency Room at Hasan Sadikin Hospital, Bandung. Trauma that occurs to the facial area is very susceptible to causing problems, both aesthetic sensory and motor function problems in that area. The existence of important structures in the facial area, such as the parotid gland and the location of the Facial Nerve (N.VII) in the facial area, requires special attention in treating soft tissue trauma to the face. Emergency management aims to ensure appropriate action in treating wounds, preventing infection, and ensuring the presence or absence of gland damage, as well as involvement of N.VII damage. Management of soft tissue wounds in the facial area is carried out by suturing, pain management and administering antibiotics. Emergency management of soft tissue trauma must be carried out quickly and precisely to obtain maximum results and consider function and aesthetics. Case report: A 16 year old female came with complaints of bleeding from the face and ears due to a motorbike accident approximately 2 hours before entering the hospital. Physical examination revealed an asymmetrical face, a torn wound on the left cheek with the parotid gland exposed and otorrhea. The patient's intraoral examination was normal. Conclusion: In this paper we will report a case of trauma to the maxillofacial soft tissue with exposure of the parotid gland. It is hoped that this article will expand insight into how to examine damage to the parotid gland and examine the function of N.VII in soft tissue trauma to the facial area. Keywords: Facial Soft Tissue Trauma; Parotid Gland; Management, N.VII
简介:口腔颌面软组织创伤在万隆哈桑萨迪金医院的急诊室经常发生。发生在面部区域的创伤很容易引起问题,包括该区域的美感和运动功能问题。面部区域重要结构的存在,如腮腺和面神经(N.VII)在面部区域的位置,在治疗面部软组织创伤时需要特别注意。应急管理的目的是确保采取适当的行动治疗伤口,防止感染,并确保是否存在腺体损伤,以及是否涉及N.VII损伤。面部软组织伤口的处理是通过缝合、疼痛管理和使用抗生素来进行的。软组织创伤的急诊处理必须快速准确地进行,以获得最大的效果,并考虑功能和美观。病例报告:一名16岁女性,在入院前约2小时发生摩托车事故,主诉面部和耳朵出血。体格检查显示面部不对称,左脸颊撕裂伤口,腮腺外露,耳漏。患者口腔内检查正常。结论:本文报告一例颌面部软组织外伤伴腮腺外露的病例。希望本文能对如何检查腮腺损伤和检查N.VII在面部软组织损伤中的作用有更深入的了解。关键词:面部软组织损伤;腮腺;管理、N.VII
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引用次数: 0
Prevalence of Squamous Cell Carcinoma of Oral Cavity at Oral and Maxillofacial Surgery Department Dr. Hasan Sadikin Hospital Period of 2019-2020 哈桑·萨迪金医院口腔颌面外科2019-2020年口腔鳞状细胞癌患病率分析
Pub Date : 2023-10-16 DOI: 10.32553/ijmbs.v7i10.2736
Timotius Andi Kadrianto, Andri Hardianto, Melita Sylvyana
Background: International Agency Data for Research on Cancer (IARC) in 2018 showed that cancer of the lips and oral cavity was ranked the 17th most common cancer in the world, there were 354,864 new cases of oral cancer in the world and cases of death from oral cancer were 177,384. case. New cases of oral cancer in Indonesia in 2018 were 5,078 cases and cases of death caused by oral cancer were 2,326 cases. Research on the characteristics of squamous cell carcinoma in the oral cavity in Indonesia is still relatively low. Objective: To analyze the prevalence of squamous cell carcinoma patients in the oral cavity at the Department of Oral and Maxillofacial Surgery, Dr. Hasan Sadikin Hospital Bandung from January 2019 to December 2020. Methods: Retrospective observational study by taking medical record data of patients with oral squamous cell carcinoma which had been clarified from histopathological results at the Oral Surgery Clinic, Dr. Hasan Sadikin Bandung. The sampling process was carried out using a purposive sampling method. The variables in this study were age, gender, location of the lesion, histopathological features, duration of the lesion and the complications caused. Data analysis using Microsoft Excel program. Results: The number of respondents aged 25-36 years as many as 4 people or 14%, ages 37-48 years as many as 7 people or 24%, and ages over 48 years as many as 18 people or 62%. There were 12 male patients or 41% and 17 female patients or 59%. Patients with a history of smoking as many as 10 people or 33%, a history of chronic irritation as many as 6 people or 20% and others as many as 14 people or 20%. The results of anatomical pathology showed that patients with poorly differentiated were 0 people or 0%, moderately differentiated were 9 people or 41%, well differentiated were 12 people or 55%, and others were 1 person or 4%. Conclusion: The age criteria of patients with the most squamous cell carcinoma are over 48 years old as many as 18 people or 62%. Based on the gender criteria, the patients with the highest incidence of squamous cell carcinoma tumors were 17 people or 59% female. anatomical pathology well differentiated as many as 12 people or 55%. Keywords: squamous cell carcinoma, oral cancer, patient characteristics
背景:2018年国际癌症研究机构数据(IARC)显示,口腔癌在全球最常见的癌症中排名第17位,全球口腔癌新发病例为354864例,口腔癌死亡病例为177384例。的情况。2018年印尼口腔癌新发病例为5078例,口腔癌致死病例为2326例。对印度尼西亚口腔鳞状细胞癌特征的研究仍然相对较少。目的:分析2019年1月至2020年12月万隆哈桑·萨迪金医生医院口腔颌面外科口腔鳞状细胞癌患者的患病率。方法:利用口腔外科诊所Hasan Sadikin Bandung医生的组织病理学结果明确的口腔鳞状细胞癌患者的病历资料进行回顾性观察研究。抽样过程采用目的性抽样方法进行。本研究的变量包括年龄、性别、病变部位、组织病理学特征、病变持续时间和并发症。使用Microsoft Excel程序进行数据分析。结果:25-36岁的受访者多达4人,占14%;37-48岁的受访者多达7人,占24%;48岁以上的受访者多达18人,占62%。男性12例,占41%;女性17例,占59%。有吸烟史的患者多达10人(33%),有慢性刺激史的患者多达6人(20%),其他患者多达14人(20%)。解剖病理结果显示:低分化0例(0%),中度分化9例(41%),高分化12例(55%),其他1例(4%)。结论:年龄标准以48岁以上的鳞状细胞癌患者最多,达18例(62%)。根据性别标准,鳞状细胞癌发病率最高的患者为17人,女性占59%。解剖病理分化良好者多达12人,占55%。关键词:鳞状细胞癌,口腔癌,患者特征
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引用次数: 0
Emergency Management of Symphysis and Right Angle of Mandible Fracture with Laceration Wound at Buccal and Submental Region: A Case Report 下颌联合及直角骨折伴颊颏下区撕裂伤的急诊处理1例
Pub Date : 2023-10-16 DOI: 10.32553/ijmbs.v7i10.2725
Tendi Fauzi, Winarno Priyanto, Endang Syamsudin
Introduction: Fracture of the mandible is a case that is quite commonly found in the ER of The Oral and Maxillofacial Surgery Department at Dr. Hasan Sadikin General Hospital Bandung, fractures of the mandible rank second to fractures of the facial area because it is a prominent bone that is located at the edge and position in the lower third of the face. Emergency management aims to take any appropriate action, prevent complications, and consult other departments involved. Objective: To explain the emergency management of symphysis and right angle of mandible fracture with laceration wound at buccal and submental region. Case report: A manage 21 year came with bleeding from the mouth due to a motorcycle accident approximately 24 hours before admission to the hospital. Physical examination showed asymmetrical face, edema at right cheek region, laceration wound at right cheek and chin region, and multiple abrasive wound at facial region. There were steps, crepitus on symphysis, and right angle of mandible region. Intraoral examination showed laceration wounds on the gingiva. Case management: The laceration area is then sutured both intraoral and extraoral followed by the application of closed reduction in the mandible with interdental wiring at the lower jaw aiming to prevent infection and malunion. The management of soft tissue and hard tissue injury is by reduction, fixation, and immobilization of fractures, management of pain, and administration of antibiotics. Conclusion: The emergency management of symphysis and right angle of mandible fracture with laceration wound at the buccal and submental region is promptly and rapidly carried out with minimal intervention by using closed reduction method gave good results in stability and function before definitive treatment.
简介:下颌骨骨折是万隆哈桑·萨迪金总医院口腔颌面外科急诊室的常见病,下颌骨是位于面部边缘和下方三分之一的突出骨,其骨折排名仅次于面部骨折。应急管理的目的是采取任何适当的行动,防止并发症,并咨询其他有关部门。目的:探讨下颌联合角骨折伴颊颏下区撕裂伤的急诊处理方法。病例报告:一位21岁的管理人员在入院前大约24小时因摩托车事故而口出血。体格检查:面部不对称,右脸颊水肿,右脸颊及下巴有撕裂伤,面部多处磨蚀伤。下颌区有台阶、联合肌捻肌、直角。口腔内检查显示牙龈有撕裂伤。病例处理:然后在口腔内和口腔外缝合撕裂区,随后在下颌骨进行闭合复位,并在下颌进行齿间钢丝连接,以防止感染和畸形愈合。软组织和硬组织损伤的处理是通过复位、固定和固定骨折、控制疼痛和使用抗生素。结论:下颌骨联合及直角骨折合并颊颏下区撕裂伤急诊处理及时、快速、干预少,采用闭合复位法治疗,在最终治疗前具有良好的稳定性和功能。
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引用次数: 0
Characteristics of Patients with Follicular Ameloblastoma at Oral Surgery Department of Dr. Hasan Sadikin General Hospital 2019 - 2020 2019 - 2020年哈桑·萨迪金综合医院口腔外科滤泡性成釉细胞瘤患者特征分析
Pub Date : 2023-10-16 DOI: 10.32553/ijmbs.v7i10.2738
Yasinnurrasyad Azmabasyar Rausyanfikr, Agus Nurwiadh, Asri Arumsari
Introduction: Ameloblastoma is the most common odontogenic tumor. Ameloblastoma is an intermediate (borderline) tumor since it is benign but locally invasive with a high recurrence rate if the excision is incomplete. Radiologically it can be monocystic or polycystic and histopathologically shows different characteristics with the follicular as the most occurrence type. Method: This research is a descriptive study using medical record data of patients who diagnosed with ameloblastoma. The population for this study were patients with a diagnosis of follicular type ameloblastoma from January 2019 to December 2020 at the Oral Surgery Department of Dr. Hassan Sadikin Hospital. Result: The result shows ameloblastoma occurred in 62% of women (26 patients) and 38% of men (16 patients). The type of ameloblastoma was varies, as the follicular type was found in 24 cases (57%), followed by the plexiform type which was found in 16 cases (38%) and the mixed plexiform-follicular type was found in 2 cases (5%). The treatment shows the conservative management of ameloblastoma using the dredging method in 9 patients (21%). Radical management of these data involved marginal resection in 1 patient (2%), segmental resection in 18 patients (43%), hemimaxillectomy in 3 patients (7%), and hemimandibulectomy in 11 patients (26%) Conclusion: ameloblastoma is more common in women than men. The follicular type is more common than plexiform or the mixed type of ameloblastoma. Based on the location of the ameloblastoma, the most common is the mandible. Radical surgery is the most common used for ameloblastoma management. Keywords: Follicular Ameloblastoma, Oral Surgery
成釉细胞瘤是最常见的牙源性肿瘤。成釉细胞瘤是一种中间(交界性)肿瘤,因为它是良性的,但局部侵袭性的,如果切除不完全,复发率很高。放射学表现为单囊性或多囊性,组织病理学表现为不同的特点,以滤泡型为多见。方法:本研究是一项描述性研究,使用诊断为成釉细胞瘤的患者的病历资料。本研究的人群是2019年1月至2020年12月在哈桑·萨迪金医生医院口腔外科诊断为滤泡型成釉细胞瘤的患者。结果:女性成釉细胞瘤发生率为62%(26例),男性为38%(16例)。成釉细胞瘤类型多样,滤泡型24例(57%),丛状型16例(38%),丛状-滤泡混合型2例(5%)。9例(21%)患者采用疏通法保守治疗成釉细胞瘤。这些数据的根治性治疗包括1例(2%)边缘切除,18例(43%)部分切除,3例(7%)半腋下切除术,11例(26%)半下颌切除术。结论:成釉细胞瘤在女性中比男性更常见。滤泡型比丛状型或混合型成釉细胞瘤更常见。根据成釉细胞瘤的位置,最常见的是下颌骨。根治性手术是治疗成釉细胞瘤最常用的方法。关键词:滤泡性成釉细胞瘤;口腔外科
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引用次数: 0
Formulation of Metoprolol Tartarate Containing Lyophilized Oral Disintegrating Tablet 酒石酸美托洛尔冻干口腔崩解片的研制
Pub Date : 2023-09-28 DOI: 10.32553/ijmbs.v7i9.2735
Shashank Gupta, Sachin Kumar Jain, Sudha Vengurlekar
a
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引用次数: 0
Peripheral Ossifying Fibroma in A Pregnant Female – A Case Report 妊娠女性外周骨化纤维瘤1例报告
Pub Date : 2023-09-27 DOI: 10.32553/ijmbs.v7i9.2732
Jaspreet Kaur, Baljeet Singh, Akshita Singh Thakur, Tanvi Ohri
The gingiva is often the site of localized growths that are considered to be reactive rather than neoplastic in nature. Many of these lesions are difficult to be identified clinically and can be identified as specific entity only on the basis of typical and consistent histomorphology. Peripheral ossifying fibroma (POF) is one of the inflammatory reactive hyperplasia of gingiva. It is a non-neoplastic entity, which occurs on the gingiva in response to trauma or irritation. A clinical report of a 26-year-old pregnant female with a large peripheral ossifying fibroma in the anterior maxilla showing significant growth is presented. Keywords: Ossifying fibroma, pyogenic granuloma, trimester, osteogenesis, exostoses.
牙龈通常是局部生长的地方,被认为是反应性的,而不是本质上的肿瘤。其中许多病变在临床上难以识别,只能根据典型和一致的组织形态学来识别为特定的实体。外周骨化性纤维瘤(POF)是牙龈炎症反应性增生的一种。它是一种非肿瘤实体,发生在牙龈上的创伤或刺激的反应。本文报告一位二十六岁孕妇,其上颌骨前部有一巨大的外周骨化纤维瘤,生长明显。关键词:骨化性纤维瘤,化脓性肉芽肿,妊娠期,成骨,外植骨。
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引用次数: 0
期刊
International Journal of Medical and Biomedical Studies
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