Pub Date : 2023-04-29DOI: 10.32553/ijmbs.v7i4.2704
Dr. Md. Izhar Alam, Dr. Abdul Nasir Ansari Ansari
Fenugreek is a wonderful herb with impressive therapeutic and nutritional benefits and has been in use for thousands of years in Ayurveda, Unani, and Chinese medicine both as medicine and spice. It is a rich source of iron, magnesium, alkaloids, saponins, flavonoids and steroids. Recent researches have highly explored its antidiabetic, anticarcinogenic, hypocholesteremic, anti-oxidant, and immunological actions. Seeing the volume and trend of research on the said herb, least work has been done with reference to this valuable plant in Unani medicine. It is a sincere effort of authors to accurately present the invaluable benefits mentioned in Unani classical literature.
{"title":"Therapeutic and Nutritional Properties of Fenugreek in Unani Medicine: A Short Review","authors":"Dr. Md. Izhar Alam, Dr. Abdul Nasir Ansari Ansari","doi":"10.32553/ijmbs.v7i4.2704","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2704","url":null,"abstract":"Fenugreek is a wonderful herb with impressive therapeutic and nutritional benefits and has been in use for thousands of years in Ayurveda, Unani, and Chinese medicine both as medicine and spice. It is a rich source of iron, magnesium, alkaloids, saponins, flavonoids and steroids. Recent researches have highly explored its antidiabetic, anticarcinogenic, hypocholesteremic, anti-oxidant, and immunological actions. Seeing the volume and trend of research on the said herb, least work has been done with reference to this valuable plant in Unani medicine. It is a sincere effort of authors to accurately present the invaluable benefits mentioned in Unani classical literature.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83138010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.32553/ijmbs.v7i4.2692
Dr. Jaspreet Kaur, Dr. Viniti Goel, D. Grover, Dr. Shikha Parihar, Dr. Tanvi Ohri, Deepak Bala, Dr. Sukriti Dhanda
Rehabilitation of atrophied/resorbed edentulous jaws by placing implants is a challenging procedure. Although various bone augmentation procedure like ridge augmentation, sinus lift is in practice but it may lead to the morbidity of donor’s site. Sometimes patient is not willing for such extensive surgical procedures. In such cases Cortical/basal implants is a viable treatment option. Basal implants gives support from the basal bone area which usually remains free from the infection and less prone to resorption. This study was undertaken to assess clinically and radiographically the bone levels in rehabilitation of immediate loading and delayed loading in opposite arch in an occlusion for a period of 1 year. After placing the implants, immediate loading was done within 72 hours for basal implants and conventional implants were placed in the lower partially edentulous sites.
{"title":"Segmental Rehabilitation of Partially Edentulous Sites with Basal Cortical and Conventional Implants – A 1 Year Clinical Trial","authors":"Dr. Jaspreet Kaur, Dr. Viniti Goel, D. Grover, Dr. Shikha Parihar, Dr. Tanvi Ohri, Deepak Bala, Dr. Sukriti Dhanda","doi":"10.32553/ijmbs.v7i4.2692","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2692","url":null,"abstract":"Rehabilitation of atrophied/resorbed edentulous jaws by placing implants is a challenging procedure. Although various bone augmentation procedure like ridge augmentation, sinus lift is in practice but it may lead to the morbidity of donor’s site. Sometimes patient is not willing for such extensive surgical procedures. In such cases Cortical/basal implants is a viable treatment option. Basal implants gives support from the basal bone area which usually remains free from the infection and less prone to resorption. This study was undertaken to assess clinically and radiographically the bone levels in rehabilitation of immediate loading and delayed loading in opposite arch in an occlusion for a period of 1 year. After placing the implants, immediate loading was done within 72 hours for basal implants and conventional implants were placed in the lower partially edentulous sites.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80504255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.32553/ijmbs.v7i4.2691
Shikha Parihar, Dr. Benni Budhwar, Dr. Viniti Goel, D. Grover, Dr. Jaspreet Kaur, Dr. Parul Sharma
The interdisciplinary relationship between periodontics and orthodontics is a highly demanding, complex clinical need of the time which requires meticulous diagnosis, treatment planning for successful long-term prognosis. The periodontal status of even young patients has been altered so it is of utmost importance that orthodontic patients has to be ruled out suffering from plaque induced gingivitis and compromised periodontal status. It is the role of the orthodontist to screen the disease, make provisional diagnosis and refer to a periodontist for immediate treatment as without periodontal therapy the severity and extent of the disease may progress. So, the orthodontist has a great role in bringing up awareness not only before starting the appliance therapy, but also during and after the active mechanotherapy. This paper has emphasized the potential of orthodontic therapy in improving or degrading periodontal health and so the relevance of periodontal planning prior and during orthodontic treatment. Key Words: Interdisciplinary, Periodontics, Orthodontics, Plaque related gingivitis
{"title":"Is it Safe to Undergo Orthodontic Therapy in Periodontitis Patient? A Review and a Case-Report","authors":"Shikha Parihar, Dr. Benni Budhwar, Dr. Viniti Goel, D. Grover, Dr. Jaspreet Kaur, Dr. Parul Sharma","doi":"10.32553/ijmbs.v7i4.2691","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2691","url":null,"abstract":"The interdisciplinary relationship between periodontics and orthodontics is a highly demanding, complex clinical need of the time which requires meticulous diagnosis, treatment planning for successful long-term prognosis. The periodontal status of even young patients has been altered so it is of utmost importance that orthodontic patients has to be ruled out suffering from plaque induced gingivitis and compromised periodontal status. It is the role of the orthodontist to screen the disease, make provisional diagnosis and refer to a periodontist for immediate treatment as without periodontal therapy the severity and extent of the disease may progress. So, the orthodontist has a great role in bringing up awareness not only before starting the appliance therapy, but also during and after the active mechanotherapy. This paper has emphasized the potential of orthodontic therapy in improving or degrading periodontal health and so the relevance of periodontal planning prior and during orthodontic treatment.\u0000Key Words: Interdisciplinary, Periodontics, Orthodontics, Plaque related gingivitis","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83358085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-24DOI: 10.32553/ijmbs.v7i4.2693
Mustaqueem Farooque, K. Saxena, Venkatrao Koti, Swosti Mohanty
Background: Androgenetic alopecia (AGA) is a hereditary androgen-dependent disorder, characterized by a progressive decline in hair fibre production by scalp hair follicles and their eventual miniaturization. Metabolic syndrome is a cluster of inter-related risk factors that increase the risk of coronary artery disease. Despite the high burden of Androgenetic Alopecia and Metabolic Syndrome in India, specific data on the participants are relatively sparse. Methods: A total of 126 patients of androgenetic alopecia (age range 18-55 years; mean age 30.83±10.37 years; 83.3% males) falling in sampling frame were enrolled in the study and were assessed clinically, anthropometrically and biochemically. Metabolic syndrome was diagnosed using Joint interim statement of International Diabetes Federation, National Heart, Lung and Blood Institute, American Heart Association, World Health Federation, International Atherosclerosis Society, and International Association of the Study of Obesity criteria. Results: Prevalence of Metabolic Syndrome (MetS) was 29.4% in 126 cases of Androgenetic Alopecia. The P Value was <0.001 for obesity (52.4%), hypertension (35.7%), low HDL cholesterol (21.4%), hypertriglyceridemia (13.5%) and high fasting glucose (12.7%) respectively. Patients with higher severity grade of AGA had significantly higher prevalence of MetS and its components. Conclusions: Metabolic Syndrome showed a positive relation with Androgenetic Alopecia. Early screening for Metabolic Syndrome is beneficial in patients with androgenic alopecia to prevent them from developing coronary artery disease.
{"title":"METABOLIC SYNDROME IN PATIENTS WITH ANDROGENETIC ALOPECIA IN A TERTIARY CARE HOSPITAL","authors":"Mustaqueem Farooque, K. Saxena, Venkatrao Koti, Swosti Mohanty","doi":"10.32553/ijmbs.v7i4.2693","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2693","url":null,"abstract":"Background: Androgenetic alopecia (AGA) is a hereditary androgen-dependent disorder, characterized by a progressive decline in hair fibre production by scalp hair follicles and their eventual miniaturization. Metabolic syndrome is a cluster of inter-related risk factors that increase the risk of coronary artery disease. Despite the high burden of Androgenetic Alopecia and Metabolic Syndrome in India, specific data on the participants are relatively sparse. \u0000 \u0000Methods: A total of 126 patients of androgenetic alopecia (age range 18-55 years; mean age 30.83±10.37 years; 83.3% males) falling in sampling frame were enrolled in the study and were assessed clinically, anthropometrically and biochemically. Metabolic syndrome was diagnosed using Joint interim statement of International Diabetes Federation, National Heart, Lung and Blood Institute, American Heart Association, World Health Federation, International Atherosclerosis Society, and International Association of the Study of Obesity criteria. \u0000 \u0000Results: Prevalence of Metabolic Syndrome (MetS) was 29.4% in 126 cases of Androgenetic Alopecia. The P Value was <0.001 for obesity (52.4%), hypertension (35.7%), low HDL cholesterol (21.4%), hypertriglyceridemia (13.5%) and high fasting glucose (12.7%) respectively. Patients with higher severity grade of AGA had significantly higher prevalence of MetS and its components. \u0000 \u0000Conclusions: Metabolic Syndrome showed a positive relation with Androgenetic Alopecia. Early screening for Metabolic Syndrome is beneficial in patients with androgenic alopecia to prevent them from developing coronary artery disease.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73787543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-16DOI: 10.32553/ijmbs.v7i4.2696
Akhil Chandran, B. Paul, Vijay K Ashok
Introduction: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality Worldwide. The understanding of metabolic and hormonal abnormalities in milder forms of renal dysfunction is expanding, but the knowledge of thyroid dysfunction in people with CKD is still limited. The growth, differentiation, and regulation of physiological mechanisms in all tissues, including the kidney, depend on thyroid hormones. They are essential for maintaining the balance of electrolytes and water. Prevalence of hypothyroidism in end stage renal disease (ESRD) has been estimated to be in the range of 0 to 9%. Patients with ESRD also have a higher prevalence of goitre. Although there are several indicators that can predict both overall mortality and the severity of renal impairment, thyroid dysfunction is one of the major ones. In order to improve the outcome, it is wise for the internist and treating physician to be aware of thyroid dysfunction. The importance of knowing the prevalence of thyroid dysfunction in CKD patients also lies in the fact that it adds to the already high cardiovascular mortality risk in this patient group. Objectives To find the proportion of thyroid dysfunction in patients with chronic kidney disease. To study the correlation between thyroid dysfunction and severity of renal diseases. Methodology A single center cross sectional study conducted in Departments of General Medicine and Nephrology in a tertiary care hospital in Calicut, Kerala. In the study period of 12 months, among patients admitted in Medical Ward after applying inclusion and exclusion criteria, 100 patients were included in the study. Patients who fulfilled the criteria for CKD and who are on conservative management and haemodialysis were taken up for the study. Thyroid profile was done in all patients who fulfilled the criteria. The prevalence of thyroid dysfunction in chronic kidney disease was described and analyzed in terms of percentages and averages. One way ANOVA test was used to analyze various parameters like T3, T4, Blood urea and Serum creatinine in relation to various grades of renal failure. Results Low T3 levels were seen in 65% and subclinical hypothyroidism was seen in 17% of the study subjects. Low T4 was seen in only 6% of the study subjects. There was no significant association observed between CKD stages and T3, T4, TSH values categorized as low, high and normal. Conclusion Low T3 syndrome was the commonest abnormality detected. This may be viewed as protective mechanism to conserve protein in chronic kidney disease patients. Subclinical hypothyroidism was the second most common abnormality detected and the number of patients with subclinical hypothyroidism progressively increased with the severity of chronic kidney disease. As subclinical hypothyroidism is associated with increased cardiovascular mortality in CKD patients, adult patients with CKD should be routinely screened for subclinical hypothyroidism and further studies ar
慢性肾脏疾病(CKD)是世界范围内发病率和死亡率的主要原因。对轻度肾功能障碍的代谢和激素异常的了解正在扩大，但对CKD患者甲状腺功能障碍的了解仍然有限。包括肾脏在内的所有组织的生长、分化和生理机制的调节都依赖于甲状腺激素。它们对维持电解质和水的平衡至关重要。终末期肾病(ESRD)中甲状腺功能减退的患病率估计在0 - 9%之间。ESRD患者也有较高的甲状腺肿患病率。虽然有几个指标可以预测总体死亡率和肾功能损害的严重程度，但甲状腺功能障碍是主要指标之一。为了提高治疗效果，内科医生和主治医师对甲状腺功能障碍的认识是明智的。了解CKD患者中甲状腺功能障碍的患病率的重要性还在于，它增加了该患者群体中已经很高的心血管死亡风险。目的了解慢性肾病患者中甲状腺功能障碍的比例。目的:探讨甲状腺功能障碍与肾脏疾病严重程度的相关性。方法:在喀拉拉邦卡利科特一家三级保健医院的普通内科和肾脏病科进行的单中心横断面研究。在12个月的研究期间，在应用纳入和排除标准后入住内科病房的患者中，有100例患者被纳入研究。符合CKD标准并接受保守治疗和血液透析的患者被纳入研究。对所有符合标准的患者进行甲状腺检查。慢性肾脏疾病中甲状腺功能障碍的患病率用百分比和平均值来描述和分析。采用单因素方差分析(One - way ANOVA)分析T3、T4、尿素、血清肌酐等参数与不同程度肾功能衰竭的关系。结果65%的患者T3水平过低，17%的患者有亚临床甲状腺功能减退。只有6%的研究对象出现低T4水平。CKD分期与T3、T4、TSH低、高、正常无显著相关性。结论低T3综合征是最常见的异常。这可能被视为慢性肾病患者保存蛋白质的保护机制。亚临床甲状腺功能减退是第二常见的异常检测，亚临床甲状腺功能减退患者的数量随着慢性肾脏疾病的严重程度逐渐增加。由于亚临床甲状腺功能减退与CKD患者心血管死亡率增加相关，成人CKD患者应常规筛查亚临床甲状腺功能减退，需要进一步研究集中于改善CKD甲状腺功能减退的临床和生化标准。
{"title":"Thyroid Dysfunction in Chronic Kidney Disease: A Study from North Kerala","authors":"Akhil Chandran, B. Paul, Vijay K Ashok","doi":"10.32553/ijmbs.v7i4.2696","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2696","url":null,"abstract":"Introduction: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality Worldwide. The understanding of metabolic and hormonal abnormalities in milder forms of renal dysfunction is expanding, but the knowledge of thyroid dysfunction in people with CKD is still limited. The growth, differentiation, and regulation of physiological mechanisms in all tissues, including the kidney, depend on thyroid hormones. They are essential for maintaining the balance of electrolytes and water. Prevalence of hypothyroidism in end stage renal disease (ESRD) has been estimated to be in the range of 0 to 9%. Patients with ESRD also have a higher prevalence of goitre. Although there are several indicators that can predict both overall mortality and the severity of renal impairment, thyroid dysfunction is one of the major ones. In order to improve the outcome, it is wise for the internist and treating physician to be aware of thyroid dysfunction. The importance of knowing the prevalence of thyroid dysfunction in CKD patients also lies in the fact that it adds to the already high cardiovascular mortality risk in this patient group. \u0000Objectives \u0000 \u0000To find the proportion of thyroid dysfunction in patients with chronic kidney disease. \u0000To study the correlation between thyroid dysfunction and severity of renal diseases. \u0000 \u0000Methodology \u0000A single center cross sectional study conducted in Departments of General Medicine and Nephrology in a tertiary care hospital in Calicut, Kerala. In the study period of 12 months, among patients admitted in Medical Ward after applying inclusion and exclusion criteria, 100 patients were included in the study. Patients who fulfilled the criteria for CKD and who are on conservative management and haemodialysis were taken up for the study. Thyroid profile was done in all patients who fulfilled the criteria. The prevalence of thyroid dysfunction in chronic kidney disease was described and analyzed in terms of percentages and averages. One way ANOVA test was used to analyze various parameters like T3, T4, Blood urea and Serum creatinine in relation to various grades of renal failure. \u0000Results \u0000Low T3 levels were seen in 65% and subclinical hypothyroidism was seen in 17% of the study subjects. Low T4 was seen in only 6% of the study subjects. There was no significant association observed between CKD stages and T3, T4, TSH values categorized as low, high and normal. \u0000Conclusion \u0000Low T3 syndrome was the commonest abnormality detected. This may be viewed as protective mechanism to conserve protein in chronic kidney disease patients. Subclinical hypothyroidism was the second most common abnormality detected and the number of patients with subclinical hypothyroidism progressively increased with the severity of chronic kidney disease. As subclinical hypothyroidism is associated with increased cardiovascular mortality in CKD patients, adult patients with CKD should be routinely screened for subclinical hypothyroidism and further studies ar","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85869449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-13DOI: 10.32553/ijmbs.v7i4.2695
Rijas K.M, Reeta James, M. Shafi
Introduction: Vitamin D plays an important role in glucose metabolism. Several pleiotropic effects of Vitamin D have been studied like regulation of cell proliferation, suppression of cell mediated immunity, Glial cell line-derived neurotrophic factor, stimulation of nerve growth factor, suppression of Renin-angiotensin-aldosterone system (RAAS), reduction of albuminuria, immunomodulatory effects, and anti-inflammatory effects.(1)Thus, vitamin D is implicated in the pathogenesis of retinopathy, neuropathy and nephropathy. Materials and Methods: A Cross-sectional case-control study of 206 patients (>30 years), who met the American Diabetes Association, 2011 criteria (2) for type 2 DM, was conducted. Subjects were evaluated for the presence of microvascular complications by clinical evaluation, urine examination, fundus examination, clinical neuropathy scoring, and various biochemical tests. 25-OH cholecalciferol levels were done and cut off level for vitamin D deficiency was 30 ng/ml. 72 Vitamin D sufficient and 134 Vitamin D deficient cases were studied. Results: A total of 134 T2DM cases with Vitamin D deficiency were studied. 72 age matched T2DM patients with sufficient Vitamin D levels served as controls. The mean age of cases under study was 47.58 ± 9.63 years compared to 51.24 ± 8.75 years of controls. 61.2% were females, whereas 38.8% were males in the case group while in the control group, 69.4% were males, and 30.5% were females. The mean duration of diabetes in the cases studied was 57.08 ± 18.13 months. It was 52.69 ± 17.98 months in the Vitamin D sufficient controls. Significant statistical associations were established using Chi square test between Vitamin D status and development of microvascular complications like Diabetic nephropathy, retinopathy and neuropathy in Type 2 Diabetes Mellitus at p < 0.05. Conclusion and Implication: Vitamin D is an important factor in modifying the risk of Type 2 DM and its microvascular complications, especially Diabetic retinopathy, neuropathy and nephropathy. Administration of vitamin D supplements may prove to be a beneficial adjuvant therapy in mitigating microvascular complications. Frequent Monitoring of Vitamin D status can decrease the burden of co-morbidities in T2DM and thus can decrease the mortality rate associated with T2DM. However; the exact role of vitamin D in these processes requires further investigations. Keywords: Diabetes, Nephropathy, Neuropathy, Retinopathy, Vitamin D
{"title":"Vitamin D Levels and Microvascular Complications in Type 2 Diabetes Mellitus Patients: A Study from North Keral","authors":"Rijas K.M, Reeta James, M. Shafi","doi":"10.32553/ijmbs.v7i4.2695","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2695","url":null,"abstract":"Introduction: Vitamin D plays an important role in glucose metabolism. Several pleiotropic effects of Vitamin D have been studied like regulation of cell proliferation, suppression of cell mediated immunity, Glial cell line-derived neurotrophic factor, stimulation of nerve growth factor, suppression of Renin-angiotensin-aldosterone system (RAAS), reduction of albuminuria, immunomodulatory effects, and anti-inflammatory effects.(1)Thus, vitamin D is implicated in the pathogenesis of retinopathy, neuropathy and nephropathy. \u0000Materials and Methods: A Cross-sectional case-control study of 206 patients (>30 years), who met the American Diabetes Association, 2011 criteria (2) for type 2 DM, was conducted. Subjects were evaluated for the presence of microvascular complications by clinical evaluation, urine examination, fundus examination, clinical neuropathy scoring, and various biochemical tests. 25-OH cholecalciferol levels were done and cut off level for vitamin D deficiency was 30 ng/ml. 72 Vitamin D sufficient and 134 Vitamin D deficient cases were studied. \u0000Results: A total of 134 T2DM cases with Vitamin D deficiency were studied. 72 age matched T2DM patients with sufficient Vitamin D levels served as controls. The mean age of cases under study was 47.58 ± 9.63 years compared to 51.24 ± 8.75 years of controls. 61.2% were females, whereas 38.8% were males in the case group while in the control group, 69.4% were males, and 30.5% were females. The mean duration of diabetes in the cases studied was 57.08 ± 18.13 months. It was 52.69 ± 17.98 months in the Vitamin D sufficient controls. Significant statistical associations were established using Chi square test between Vitamin D status and development of microvascular complications like Diabetic nephropathy, retinopathy and neuropathy in Type 2 Diabetes Mellitus at p < 0.05. \u0000Conclusion and Implication: Vitamin D is an important factor in modifying the risk of Type 2 DM and its microvascular complications, especially Diabetic retinopathy, neuropathy and nephropathy. Administration of vitamin D supplements may prove to be a beneficial adjuvant therapy in mitigating microvascular complications. Frequent Monitoring of Vitamin D status can decrease the burden of co-morbidities in T2DM and thus can decrease the mortality rate associated with T2DM. However; the exact role of vitamin D in these processes requires further investigations. \u0000Keywords: \u0000Diabetes, Nephropathy, Neuropathy, Retinopathy, Vitamin D","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88150125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-03DOI: 10.32553/ijmbs.v7i4.2690
Rakesh Kumar Soni, Shailesh M Kewatkar, Vidhi Jain, M. Saluja
Plants offer a large range of natural compounds belonging to different molecular families which have various properties to humans. These molecules possess interesting biological activities which attracted several researchers to their elucidation to provide knowledge that will lead to advancement medicine. The present paper deals with the screening of various phytochemical present in various extract viz., Aqueous, Ethanolic, Ethyl Acetate, chloroform and petroleum ether of Sida Spinosa
{"title":"Phytochemical Evaluation of different Extracts of Sida Spinosa by various Chemical Test","authors":"Rakesh Kumar Soni, Shailesh M Kewatkar, Vidhi Jain, M. Saluja","doi":"10.32553/ijmbs.v7i4.2690","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2690","url":null,"abstract":"Plants offer a large range of natural compounds belonging to different molecular families which have various properties to humans. These molecules possess interesting biological activities which attracted several researchers to their elucidation to provide knowledge that will lead to advancement medicine. The present paper deals with the screening of various phytochemical present in various extract viz., Aqueous, Ethanolic, Ethyl Acetate, chloroform and petroleum ether of Sida Spinosa","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78223322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical science still faces difficulties in developing side-effect-free medications for diabetes management. This has increased the need for safe and effective natural remedies that may lower blood sugar levels. The purpose of this study is to determine whether or not an ethanolic extract of Nyctanthes arbortristis Linn. leaves reduces blood sugar levels in alloxan-induced diabetic albino rats. Nyctanthes arbortristis Linn. Ethyl Acetate extract activity was compared to that of the glibenclamide (0.5mg/kg p.o.) standard antidiabetic medication. Normal rats were given oral dosages of an Ethyl Acetate extract of Nyctanthes arbortristis Linn. leaf. At a dosage of 200 mg/kg, the Ethyl Acetate extract was significantly (p0.05) hypoglycemic. Leaves extracted with ethyl acetate from the Nyctanthes arbortristis linn plant have anti-diabetic effects on a par with those shown in diabetic control mice. Nyctanthes arbortristis linn leaf extract in ethyl acetate has been shown to have potent and non-toxic anti-diabetic properties.
{"title":"Hypoglycemic Activity Nyctanthes ArborTristis LINN. IN Alloxan Induced Diabetic Rats","authors":"Ashok Kumar Mobiya, Shailesh M Kewatkar, Vidhi Jain, Manmeet Singh Saluja","doi":"10.32553/ijmbs.v7i4.2688","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2688","url":null,"abstract":"Medical science still faces difficulties in developing side-effect-free medications for diabetes management. This has increased the need for safe and effective natural remedies that may lower blood sugar levels. The purpose of this study is to determine whether or not an ethanolic extract of Nyctanthes arbortristis Linn. leaves reduces blood sugar levels in alloxan-induced diabetic albino rats. Nyctanthes arbortristis Linn. Ethyl Acetate extract activity was compared to that of the glibenclamide (0.5mg/kg p.o.) standard antidiabetic medication. Normal rats were given oral dosages of an Ethyl Acetate extract of Nyctanthes arbortristis Linn. leaf. At a dosage of 200 mg/kg, the Ethyl Acetate extract was significantly (p0.05) hypoglycemic. Leaves extracted with ethyl acetate from the Nyctanthes arbortristis linn plant have anti-diabetic effects on a par with those shown in diabetic control mice. Nyctanthes arbortristis linn leaf extract in ethyl acetate has been shown to have potent and non-toxic anti-diabetic properties.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"2 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78285105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-03DOI: 10.32553/ijmbs.v7i4.2689
Pawan Sharma, V. Nakra, Vidhi Jain, Manmeet Singh Saluja
The purpose of this study was to examine the hepatoprotective efficacy of Whole plant extract of Adiantum capillus against Paracetamol induced liver damage in rats. Wistar albino rats were orally fed 500 mg/kg of body weight of Methanolic and Acetonic extract of Adiantum capillus Whole plant, with Silymarin serving as the reference. By restoring functional parameters, physical parameters, biochemical parameters, and decreasing blood enzymes alkaline phosphatase (ALP) and total bilirubin (TBL) in the selected animal, the methanolic and Acetonic extracts exhibited a potent hepatoprotective effect. The plant's chemical composition includes, among others, alkaloids, flavonoids, glycosides, steroids, terpenoids, phenolics, and saponins. The overall experimental data suggest that bioactive phytoconstituents, such as flavonoids and alkaloids, present in the Methanolic and Acetonic extracts of Adiantum capillus plant may be responsible for the plant's significant hepatoprotective effect. The results thus support the use of Adiantum capillus plant as a hepatoprotectant.
{"title":"Hepatoprotective Effect of Herbal Medicinal Plant Extract against Paracetamol Induced Liver Injury in Rats","authors":"Pawan Sharma, V. Nakra, Vidhi Jain, Manmeet Singh Saluja","doi":"10.32553/ijmbs.v7i4.2689","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i4.2689","url":null,"abstract":"The purpose of this study was to examine the hepatoprotective efficacy of Whole plant extract of Adiantum capillus against Paracetamol induced liver damage in rats. Wistar albino rats were orally fed 500 mg/kg of body weight of Methanolic and Acetonic extract of Adiantum capillus Whole plant, with Silymarin serving as the reference. By restoring functional parameters, physical parameters, biochemical parameters, and decreasing blood enzymes alkaline phosphatase (ALP) and total bilirubin (TBL) in the selected animal, the methanolic and Acetonic extracts exhibited a potent hepatoprotective effect. The plant's chemical composition includes, among others, alkaloids, flavonoids, glycosides, steroids, terpenoids, phenolics, and saponins. The overall experimental data suggest that bioactive phytoconstituents, such as flavonoids and alkaloids, present in the Methanolic and Acetonic extracts of Adiantum capillus plant may be responsible for the plant's significant hepatoprotective effect. The results thus support the use of Adiantum capillus plant as a hepatoprotectant.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83355443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.32553/ijmbs.v7i3.2683
M. A. Rahaman, Anurup Guha, K. Sagar
Background: Endotracheal intubation is an essential resuscitative procedure in the emergency setting, to maintain a patent airway. In our day-to-day practice at a tertiary care centre calls for intubation remain in quite a demand. As we all know in the emergency setting we first advocate maintaining the so-called A (airway), B(breathing) and C(circulation) and this is where lies the importance of intubation. Objective: The study was done to assess the knowledge, competency, and exposure regarding emergency airway management among healthcare workers in this region of West Bengal which caters to patients from the Mahananda Basin, in particular, Malda. Methodology: A questionnaire-based cross-sectional study was conducted. The study tool was a standard questionnaire containing 14 questions, which was developed to assess the knowledge, exposure, and practice of the study group in a Tertiary Care Centre of West Bengal. Results: the questionnaire based analytical study revealed gross lack of knowledge among caregivers regarding management of airway during emergency situations. Inference: Basic knowledge in terms of theory seems to prevail among almost all the participants but they lack the congruity between knowledge and exposure, hence an interactive curriculum should be designed to train the target groups in order to avoid the catastrophe seen during emergency situations.
{"title":"Knowledge, Exposure and Practice of Health Care Workers Regarding Emergency Airway Management in a Tertiary Care Centre of West Bengal: Questionnaire-Based Analytical Study","authors":"M. A. Rahaman, Anurup Guha, K. Sagar","doi":"10.32553/ijmbs.v7i3.2683","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i3.2683","url":null,"abstract":"Background: Endotracheal intubation is an essential resuscitative procedure in the emergency setting, to maintain a patent airway. In our day-to-day practice at a tertiary care centre calls for intubation remain in quite a demand. As we all know in the emergency setting we first advocate maintaining the so-called A (airway), B(breathing) and C(circulation) and this is where lies the importance of intubation. \u0000Objective: The study was done to assess the knowledge, competency, and exposure regarding emergency airway management among healthcare workers in this region of West Bengal which caters to patients from the Mahananda Basin, in particular, Malda. \u0000Methodology: A questionnaire-based cross-sectional study was conducted. The study tool was a standard questionnaire containing 14 questions, which was developed to assess the knowledge, exposure, and practice of the study group in a Tertiary Care Centre of West Bengal. \u0000Results: the questionnaire based analytical study revealed gross lack of knowledge among caregivers regarding management of airway during emergency situations. \u0000Inference: Basic knowledge in terms of theory seems to prevail among almost all the participants but they lack the congruity between knowledge and exposure, hence an interactive curriculum should be designed to train the target groups in order to avoid the catastrophe seen during emergency situations. \u0000 ","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86941943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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