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The Change of after lifting the State of Emergency by COVID-19 on the Physical Activity of the Elderly Japanese People 新冠肺炎紧急状态解除后对日本老年人身体活动的影响
Pub Date : 2022-04-27 DOI: 10.18535/ijmsci/v9i04.02
Soshi Miyahara, Hideo Hirai, Hideki Ishikura, Seiji Togashi
In April 2020, the spread of COVID-19 infectious disease in Japan issued a state of emergency, making it impossible for people to go out except for unnecessary and urgent matters. It has been reported that the declaration of self-restraint will significantly reduce the volume of physical activity (PA). However, since the volume of change in the volume of PA after 6 months or more after the declaration of self-control was lifted is unknown, the volume of PA was compared. The participants were 13 elderly people living in Hiroshima City. In October 2020, an activity meter with a 3-axis accelerometer was attached to the participant's waist, and PA and physical function were measured for one week and compared with the PA measured in October 2019. Six months after the declaration was issued, there was changes volume of moderate intensity walking PA, were no changes in the number of steps, activity time, volume of light intensity PA, and volume of total PA (p ≥ 0.07%). Six months have passed since the self-restraint of activities due to the state of emergency, and now that the number of infected people has decreased, it is possible that the volume of PA in the elderly has improved due to the improvement in the sense of security and happiness. This suggests that it is important to continue daily activities, hobbies, and exercises as much as possible while taking measures against infection in order to reduce the risk of cardiovascular events.
2020年4月,新型冠状病毒感染症(COVID-19)在日本蔓延,日本进入紧急状态,除了不必要的紧急事项外,人们无法外出。据报道,宣布自我克制会显著减少身体活动量(PA)。然而,由于在宣布自我控制解除后6个月或更长时间内PA体积的变化量是未知的,因此比较了PA体积。参与者是住在广岛市的13位老人。2020年10月,在参与者腰部安装一个带有3轴加速度计的活动计,测量一周的PA和身体功能,并与2019年10月测量的PA进行比较。6个月后,中强度步行PA量有变化,步数、活动时间、轻强度PA量、总PA量无变化(p≥0.07%)。由于紧急状态导致的自我约束活动已经过去了6个月,现在感染人数有所减少,老年人的PA量可能由于安全感和幸福感的提高而有所改善。这表明,在采取预防感染措施的同时,尽可能多地保持日常活动、爱好和锻炼,以降低心血管事件的风险是很重要的。
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引用次数: 0
Lacunar Infarction In Old Stroke: A Case Report 陈旧性脑卒中腔隙性梗死1例
Pub Date : 2022-04-12 DOI: 10.18535/ijmsci/v9i04.01
Mohammad Ridho Devantoro, W. Wijaya, Muhammad Iqbal Arigi Putra, R. Yogaswara
Introduction: Lacunar stroke accounts for nearly a quarter of all ischemic strokes and is an important cause of vascular cognitive impairment and dementia.Case Presentation: A 52-year-old man with lacunar infarct presented with weakness in his left thumb and forefinger since one day ago when he was sitting down.  The patient’s fingers appear bent as if holding a pencil and could not be straightened. Physical examination showed an high blood pressure, and paresis of the right facial and hypoglossal nerve. A non-contrast CT scan of head using the parenchymal window showed a hypodense lesion on the left pons, interpreted as a lacunar infarct.Discussion: Lacunar strokes represent approximately 25% of ischemic strokes and most are associated with good outcomes. However, in 20% to 30% of patients with lacunar stroke, early neurologic damage occurs within the first days after stroke onset. Lacunar stroke was defined as acute lacunar syndrome with infarction <15 mm in diameter in the basal ganglia, deep white matter, thalamus or pons that is not associated with large vessel atherosclerosis or a cardioembolic source.Conclusion: Lacunar infarction is a potentially reversible. These conditions can potentially be well managed with adequate treatment. 
腔隙性卒中占所有缺血性卒中的近四分之一,是血管性认知障碍和痴呆的重要原因。病例介绍:52岁男性,腔隙性脑梗死,自一天前坐下以来,表现为左拇指和食指无力。患者的手指弯曲,好像拿着铅笔,无法伸直。体格检查显示血压高,右侧面神经和舌下神经麻痹。脑实质窗非对比CT扫描显示左侧脑桥低密度病变,解释为腔隙性梗死。讨论:腔隙性卒中约占缺血性卒中的25%,大多数伴有良好的预后。然而,在20%至30%的腔隙性卒中患者中,早期神经损伤发生在卒中发作后的第一天。腔隙性卒中被定义为急性腔隙综合征,梗死直径小于15mm,发生在基底节区、深部白质、丘脑或脑桥,与大血管动脉粥样硬化或心脏栓塞源无关。结论:腔隙性梗死具有潜在的可逆性。这些情况可以通过适当的治疗得到很好的控制。
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引用次数: 0
Effectiveness of Public Health Volunteer Engagement Program in Home Care for Stroke Patients in Bo Thong District Chonburi Province, Thailand 泰国春武里省博通区公共卫生志愿者参与项目对中风患者家庭护理的效果
Pub Date : 2022-03-31 DOI: 10.18535/ijmsci/v9i03.010
Uten Sutin, Srimuang Paluangrit, S. Dangkrajang, W. Sutthinarakorn, V. Prasert
This research aimed to study the effectiveness of the Public Health Volunteer Participation Program in the home care of stroke patients.Methods: This was quasi-experimental research; the samples consisted of 30 public health volunteers in each comparison and experimental group by simple sampling. The experimental group participated the Public Health Volunteer Engagement Program that consisted of 1) improving the environment at home and supporting the physiotherapy by increasing movement to improve the body balance, 2) Stress management and social support of stroke patients at home, 3) Taking care the nutritional status among stroke patients at home, 4) Following on a daily within 12 weeks by nurse and public health volunteer. Data were collected by using the knowledge interview form on stroke and care of stroke patients. Data were analyzed by using frequency, percentage, mean, standard deviation, pair-sample t-test, and independent-sample t-test.Results: The results found that the knowledge average score and the home care practice score of the health volunteers were significantly higher than the comparison group (p < 0.001). When comparing the results before and after program implementation, the cerebrovascular disease care in public health volunteers were significantly higher than before program implementation. (P < 0.001).Conclusion: The Public Health Volunteer Engagement Program in Home Care for Stroke Patients was effective. This program was suitable for promoting the public health team to care stroke patients at the community level.
本研究旨在探讨公共卫生义工参与计划对脑卒中患者家庭照护的效果。方法:准实验研究;样本采用简单抽样法,分为对照组和实验组各30名公共卫生志愿者。实验组参与公共卫生志愿者参与计划,包括1)改善居家环境,通过增加运动来支持物理治疗,以改善身体平衡;2)居家卒中患者的压力管理和社会支持;3)居家卒中患者的营养状况;4)护士和公共卫生志愿者在12周内每天跟进一次。采用卒中及卒中患者护理知识访谈表收集数据。数据分析采用频率、百分比、均值、标准差、对样本t检验和独立样本t检验。结果:健康志愿者的知识平均分和居家护理实践分均显著高于对照组(p < 0.001)。对比项目实施前后的结果,公共卫生志愿者的脑血管疾病护理水平明显高于项目实施前。(p < 0.001)。结论:公共卫生志愿者参与项目对脑卒中患者的家庭护理是有效的。该项目适合推动公共卫生团队在社区层面护理脑卒中患者。
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引用次数: 0
Revitalization of Posyandu for the Elderly in Nagari Tapakis, Padang Pariaman Regency 巴东Pariaman摄政区Nagari Tapakis的老人院振兴计划
Pub Date : 2022-03-28 DOI: 10.18535/ijmsci/v9i03.09
S. Huvaid, Hilda Hidayat, Yulianita
The common knowledge of elderly posyandu cadres in Nagari Tapakis hurts their performance in the field. The initial survey results showed that the elderly posyandu cadres had just been formed; so far, the assigned cadres were toddler’s posyandu cadres. This makes the cadres have a double burden so that the activities of the elderly posyandu are less active even though they already exist. Since establishing the elderly posyandu cadres, no training has been held for cadres related to their primary duties and functions. The service method used is lecture, discussion, practice, and pre-test and post-test work. The training material focuses on techniques for managing the elderly posyandu and health services for the elderly that must be carried out during the Covid-19 pandemic era. Participants in the activity included 18 elderly posyandu cadres in Nagari Tapakis. On August 27, 2021, the action took place at the Tapakis Mayor's Office. The results obtained in training involving 18 elderly posyandu health cadres generally showed encouraging things. The participants responded positively and were very enthusiastic about participating in the training activities during the material presentation and discussion sessions. The pre-test and post-test values also showed a change in the form of an increase in respondents' knowledge; this was evidenced by the difference in the average understanding of respondents before counseling (13.2) and after counseling ( 16.8) with p = 0.000.
Nagari Tapakis的老年posyandu干部的常识损害了他们在该领域的表现。初步调查结果显示,老年干部队伍刚刚形成;到目前为止,分配的干部都是幼儿时期的干部。这使得干部有了双重负担,老年人的活动即使已经存在,也不那么活跃。自建立老年干部队伍以来,没有对干部进行与其主要职责和职能有关的培训。使用的服务方式是讲座、讨论、实践以及测试前和测试后的工作。培训材料侧重于在2019冠状病毒病大流行时期必须开展的老年人护理和老年人保健服务管理技术。参加活动的有Nagari Tapakis的18名老年posyandu干部。2021年8月27日,行动发生在塔帕基斯市长办公室。对18名老年保健干部的培训结果普遍令人鼓舞。在材料展示和讨论环节,学员们反应积极,对参加培训活动非常热情。测试前和测试后的值也表现出被调查者知识增加的变化形式;被调查者在咨询前(13.2)和咨询后(16.8)的平均理解差异(p = 0.000)证明了这一点。
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引用次数: 0
MTHFD2 Expression Profile and Its Prognostic Importance in Invasive Breast Carcinoma 浸润性乳腺癌中MTHFD2表达谱及其预后意义
Pub Date : 2022-03-28 DOI: 10.18535/ijmsci/v9i03.08
R. Arslan, O. Ceylan
Background: Breast cancer is the most common cancer among women. Therefore, it is very important to determine prognostic parameters and biomarkers related to these parameters. Recent studies have shown that folate metabolism is effective on cell division and invasiveness. One of the most important regulators of folate metabolism is the methylene tetrahydrofolate dehydrogenase enzyme (MTHFD2).Method:  This study, immunohistochemical staining with MTHFD2 was performed in 194 cases diagnosed with invasive breast carcinoma. The relationship between the immunohistochemical expression of MTHFD2 in normal ductal areas and invasive tumoral areas of these cases and some clinicopathological parameters was investigated.Results: While no expression was observed in non-tumor areas with MTHFD2, varying degrees of expression were observed in all tumor areas (p<0.0001). Significant correlations were also observed between important clinicopathological and prognostic parameters such as MTHFD2 nuclear grade, hormonal receptor, Ki67 and etc. (all p<0.05).Conclusion: High MTHFD2 expression in breast carcinomas with invasive and poor prognostic values ​​was determined to be very significant. Therefore, it can be predicted that detecting and lowering MTHFD2 levels in these cases may prevent tumor development, invasion and metastasis. We think that more studies on the subject are needed, including the development of chemotherapeutics targeting MTHFD2.
背景:乳腺癌是女性中最常见的癌症。因此,确定预后参数和与这些参数相关的生物标志物是非常重要的。最近的研究表明,叶酸代谢对细胞分裂和侵袭是有效的。叶酸代谢最重要的调节因子之一是亚甲基四氢叶酸脱氢酶(MTHFD2)。方法:对194例浸润性乳腺癌患者进行MTHFD2免疫组化染色。探讨MTHFD2在正常导管区及侵袭性肿瘤区免疫组化表达与临床病理参数的关系。结果:MTHFD2在非肿瘤区未见表达,但在所有肿瘤区均有不同程度表达(p<0.0001)。MTHFD2核分级、激素受体、Ki67等重要临床病理及预后指标之间也存在显著相关性(p<0.05)。结论:MTHFD2高表达在侵袭性、预后不良的乳腺癌中具有重要意义。因此,可以预测在这些病例中检测并降低MTHFD2水平可以预防肿瘤的发展、侵袭和转移。我们认为需要对这个问题进行更多的研究,包括开发针对MTHFD2的化疗药物。
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引用次数: 0
The Effect of Cigarette Smoke Exposure on Histology Liver in Male Mice 香烟烟雾暴露对雄性小鼠组织学肝脏的影响
Pub Date : 2022-03-27 DOI: 10.18535/ijmsci/v9i03.07
M. Oktora, Dessy Abdullah, Tazkiya Nur Annisa
When smoking Reactive Oxygen Species (ROS), which is a reactive oxidizing agent, can cause damage to the DNA structure of liver cells and increase the occurrence of liver necrosis. The research aims to determine the histopathological picture of the liver in male mice (Mus musculus) exposed to cigarette smoke. This research is an experimental laboratory with the sample used is male mice (Mus musculus). The sample with the most damage in treatment I obtained 5 (55.6%) samples with a score of 2 who had damage to hepatocytes. , 7 (77.8%) samples with a score of 3 had central venous dilation, 3 (33.3%) samples with a score of 1 had fatty liver, and 3 (33.3%) samples with a score of 1 had liver necrosis. While in treatment II, 5 (55.6%) samples with a score of 2 had hepatocyte cell damage, 8 (88.9%) samples with a score of 3 had central vein dilation, 5 (55.6%) samples with a score of 3 had fatty liver, and 5 (55.6%) samples with a score of 2 had liver necrosis. Based on these results, the histopathological changes in the liver of male mice (Mus musculus) were exposed to cigarette smoke.
活性氧(Reactive Oxygen Species, ROS)是一种活性氧化剂,吸烟时可引起肝细胞DNA结构的损伤,增加肝坏死的发生。该研究旨在确定暴露于香烟烟雾的雄性小鼠(小家鼠)肝脏的组织病理学图像。本研究为实验室实验,所用样本为雄性小鼠(小家鼠)。在治疗1中损伤最大的样本中,有5个(55.6%)的样本得分为2,肝细胞受损。得分为3分的有7例(77.8%)中心静脉扩张,得分为1分的有3例(33.3%)脂肪肝,得分为1分的有3例(33.3%)肝坏死。在治疗II中,5例(55.6%)评分为2分的样本出现肝细胞损伤,8例(88.9%)评分为3分的样本出现中心静脉扩张,5例(55.6%)评分为3分的样本出现脂肪肝,5例(55.6%)评分为2分的样本出现肝坏死。在此基础上,研究了雄性小鼠(小家鼠)暴露于香烟烟雾后肝脏的组织病理学变化。
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引用次数: 0
A Case Report: Acute Symptomatic Seizure Associated Brain Metastasis in Pregnant Woman 孕妇急性症状性癫痫相关脑转移1例报告
Pub Date : 2022-03-16 DOI: 10.18535/ijmsci/v9i03.06
Dian Ayu Hamama Pitra
Pregnant women can present with a wide variety of neurological conditions. Conditions including epilepsy, eclampsia, facial nerve palsy, pituitary tumor, cerebrovascular disorders, myasthenia gravis, multiple sclerosis, and nonpituitary intracranial tumors could be encountered. (Cheung, 1997). We describe a patient who presented with Acute Symptomatic Seizure Associated Brain Metastasis In Pregnant Woman. She came to the hospital because of a fit event and sudden left hemiparalysis and was diagnosed as a stroke, but further examinations revealed unexpected results. Brain imaging suggested brain metastasis was encountered, but histopathological examination did not support this data. More investigations are needed to determine the true etiology of her fit attacks. This patient’s diagnosis and management were even more challenging since she’s now at nine weeks gestation. Keywords— pregnant woman, brain metastasis, acute symptomatic seizure
孕妇可能出现各种各样的神经系统疾病。可能会遇到癫痫、子痫、面神经麻痹、垂体瘤、脑血管疾病、重症肌无力、多发性硬化症和非垂体性颅内肿瘤。(张,1997年)。我们描述了一位孕妇出现急性症状性癫痫相关脑转移的患者。她因为突然发作和左偏瘫来到医院,被诊断为中风,但进一步的检查显示了意想不到的结果。脑成像提示脑转移,但组织病理学检查不支持这一数据。需要更多的调查来确定她发作的真正病因。这位患者的诊断和治疗更具挑战性,因为她现在已经怀孕九周了。关键词:孕妇,脑转移,急性症状性癫痫
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引用次数: 0
The Association of the Use of Electronic Media with Primary Headache in Students of the Faculty of Medicine, BaiturrahMah University Class 2017 拜图拉玛大学2017级医学院学生使用电子媒体与原发性头痛的关系
Pub Date : 2022-03-15 DOI: 10.18535/ijmsci/v9i03.05
Dian Ayu Hamama Pitra, Risqi, Anita Darmayanti
Background: The use of multimedia-based electronics during this Covid pandemic is the right solution fordistance learning. Electronic media that are generally known by the public are cellphones and laptops/computers, and television which are communication media that use electromechanical power.Aims: To find the association between the use of electronic media with primary headaches in students of the Faculty of Medicine, Baiturrahmah University class 2017.Method: This research was an observational analytic study with a cross-sectional design. The sample of this study was the 2017 class of students who met the inclusion criteria and exclusion criteria—sampling using a non-random sampling method, namely consecutive selection. Data collection was done by distributing questionnaires.Results: In this study, the gender of the respondents, who were primarily women, was 50 people (72.5%). Respondents who experienced migraine headaches were 13 people (18.8%), and Tension-Type Headachewas 56 people (81.2%). This study showed no significant association between the use of cellphones and primary headaches in terms of frequency, duration, length of possession, position, and brightness (p>0.05). Likewise, for the use of laptops/computers, there was no significant association with primary headaches in terms of frequency, duration, length of stay, position, and brightness (p>0.05). Furthermore, there was no significant association with primary headaches for television use in terms of frequency, duration, length of stay, and position.Conclusion: There is no significant association between the use of electronic media with primary headache.
背景:在本次Covid大流行期间,使用基于多媒体的电子设备是远程学习的正确解决方案。大众所熟知的电子媒体是手机和笔记本电脑,电视是使用机电动力的传播媒体。目的:探讨拜图拉玛大学医学院2017级学生使用电子媒体与原发性头痛之间的关系。方法:采用横断面设计的观察性分析研究。本研究的样本为符合纳入标准和排除标准的2017级学生,采用非随机抽样方法,即连续选择。数据收集是通过发放问卷来完成的。结果:本次研究中,被调查者的性别为50人(72.5%),以女性为主。偏头痛13人(18.8%),紧张性头痛56人(81.2%)。本研究显示,使用手机与原发性头痛在频率、持续时间、使用时间、位置和亮度方面无显著关联(p>0.05)。同样,对于笔记本电脑/电脑的使用,在频率、持续时间、停留时间、位置和亮度方面与原发性头痛没有显著关联(p>0.05)。此外,看电视的频率、持续时间、停留时间和姿势与原发性头痛没有显著的关联。结论:电子媒体的使用与原发性头痛无显著相关性。
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引用次数: 0
A Case of Rickettsiosis in a Patient with Glucose-6-Phosphate Dehydrogenase (G6pd) Deficiency 葡萄糖-6-磷酸脱氢酶(G6pd)缺乏的立克次体病1例
Pub Date : 2022-03-14 DOI: 10.18535/ijmsci/v9i03.04
Garin-kol Avrahami Reut, Zerbib Olivier, Gafter Gvili Anat, Lev Shaul, G. Sahaf levin, Gottesman Tamar
Rickettsia is a group of Gram-negative intra cellular obligatory bacteria. Rickettsia species are an important cause of infectious disease in people and animals. Fleas, ticks, mite, lice etc., serve as vectors who transfer the rickettsia from animal to humans.Rickettsiosis is one of the oldest known vector-borne diseases(Blanda et al., 2020).Usually it is a nonspecific self-limiting febrile illness without major complications. Fever, headache, mild-rash, myalgia's and anorexia are the most common presenting signs and symptoms. Laboratory findings include elevated transaminase levels, hyponatremia, thrombocytopenia and anemia (Merhej et al., 2014).The disease is usually of benign nature. Severe complications are reported in about 6% of cases. Patients may present with organ involvement, severe vasculitis and multi organ failure (Oteo and Portillo, 2012) and the mortality rate is up to 2.5%(Giammanco et al., 2005; Raoult et al., 1986).
立克次体是一组革兰氏阴性细胞内专性细菌。立克次体是人类和动物传染病的重要病原体。跳蚤、蜱虫、螨虫、虱子等是将立克次体从动物传染给人类的媒介。立克次体病是已知最古老的媒介传播疾病之一(Blanda等人,2020年)。通常是一种无主要并发症的非特异性自限性发热性疾病。发烧、头痛、轻度皮疹、肌痛和厌食是最常见的症状和体征。实验室结果包括转氨酶水平升高、低钠血症、血小板减少症和贫血(Merhej et al., 2014)。这种病通常是良性的。约6%的病例报告出现严重并发症。患者可能出现器官受累、严重血管炎和多器官衰竭(Oteo and Portillo, 2012),死亡率高达2.5%(Giammanco et al., 2005;Raoult et al., 1986)。
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引用次数: 0
Isolated Right Heart Failure and Tricuspid Regurgitation in a Patient with Untreated Hyperthyroidism: A Case Report 孤立性右心衰和三尖瓣反流在未经治疗的甲亢患者:1例报告
Pub Date : 2022-03-11 DOI: 10.18535/ijmsci/v9i03.03
K. Jaya, Ni Ketut Hanny Puspita, Arsy Mira Pertiwi, I. Semadi
Introduction: Hyperthyroidism has been known to cause a variety of cardiovascular manifestations. Isolated right heart failure (RHF) occurs occasionally, is usually due to pulmonary hypertension or tricuspid valve abnormalities. In rare cases, hyperthyroidism could be the underlying disease.Case Presentation: A 72-year-old woman with suspected but untreated hyperthyroidism presented with progressive dyspnea and lower extremity swelling in the last ten days. Physical examination showed an irregular and high heart rate, increase in JVP, enlargement of the thyroid gland, systolic murmur, and clear lungs. The laboratory findings showed an elevated level of free T4 (2.51 ng/dL) and a low level of TSH (<0.003 uIU/mL). Electrocardiogram revealed atrial fibrillation with a rapid ventricular response. Echocardiography showed right atrial and right ventricular dilatation with moderate tricuspid regurgitation. Left ventricular size and systolic function were normal. Chest x-ray showed a cardiothoracic ratio of 53% with organized left pleural effusion. Symptoms resolved as her thyroid hormone levels normalized with adequate treatment.Discussion: The most common changes that result from hyperthyroidism to the cardiovascular system are increased cardiac preload, decreased peripheral vascular resistance, direct injury, increased heart rate and contractility, which together produce a hyper dynamic circulatory state that leads to increased blood volume and venous return resulting in the increased risk of RHF.Conclusion: Hyperthyroidism is a potentially reversible cause of heart failure and should be ruled out in every heart failure patient, especially in those with isolated right heart failure, tricuspid regurgitation, and pulmonary hypertension. These conditions can potentially be well managed with adequate treatment.
简介:甲状腺机能亢进已被认为可引起多种心血管症状。孤立性右心衰(RHF)偶尔发生,通常是由于肺动脉高压或三尖瓣异常。在极少数情况下,甲状腺机能亢进可能是潜在的疾病。病例介绍:一名72岁女性,疑似甲亢但未经治疗,在过去10天内出现进行性呼吸困难和下肢肿胀。体格检查显示心率不规则,心率高,JVP增高,甲状腺肿大,收缩期杂音,肺清。实验室检查结果显示游离T4水平升高(2.51 ng/dL), TSH水平低(<0.003 uIU/mL)。心电图显示心房颤动伴快速心室反应。超声心动图显示右心房和右心室扩张伴中度三尖瓣反流。左心室大小和收缩功能正常。胸部x线片显示心胸比值53%伴有组织的左胸腔积液。经适当治疗,甲状腺激素水平恢复正常,症状消失。讨论:甲状腺功能亢进对心血管系统最常见的改变是心脏预负荷增加,周围血管阻力降低,直接损伤,心率和收缩力增加,这些共同产生高动态循环状态,导致血容量增加和静脉回流,从而增加RHF的风险。结论:甲状腺功能亢进是一种潜在的可逆性心力衰竭原因,应排除所有心力衰竭患者,特别是孤立性右心衰、三尖瓣反流和肺动脉高压患者。这些情况可以通过适当的治疗得到很好的控制。
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引用次数: 0
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International Journal Of Medical Science And Clinical Invention
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