International Journal of Pharmacy and Chemistry最新文献

{"title":"A Comparative Study on the Antioxidant and Insecticidal Activities of <i>Eucalyptus camaldulensis </i>Essential Oil and Hydrosol","authors":"Affo Dermane, K. Eloh, Oudjaniyobi Simalou, Balabapaté Assiki","doi":"10.11648/j.ijpc.20241001.12","DOIUrl":"https://doi.org/10.11648/j.ijpc.20241001.12","url":null,"abstract":"The study investigates the hydrosol of <i>Eucalyptus camaldulensis</i> to assess its value and potential applications within the essential oil (EO) industry. Following steam distillation of <i>E. camaldulensis</i> leaves to extract essential oil, the resulting hydrosol underwent liquid-liquid extraction to yield a secondary essential oil (SEO). Comparative chemical analysis was performed using GC/MS. Comparative chemical analysis of the SEO and EO revealed distinct compositions, with 24 compounds identified in the SEO compared to 41 in the EO. Oxygenated compounds predominated in the SEO while non-oxygenated compounds were the most abundant in the EO (63.61%). Eucalyptol emerged as the primary constituent in both, with higher concentrations observed in the SEO (60.41%) than in the EO (28.53%). Additionally, antioxidant activity assessed using the DPPH assay demonstrated significant radical reduction in the SEO compared to the EO. In insecticidal tests targeting Callosobruchus maculatus, the SEO exhibited pronounced toxicity, with an IC₅₀ value lower than that of the EO. This study showed the abundance of oxygenated compounds in <i>E. camaldulensis</i> hydrosol compared to pure essential oil, suggesting its potential as an antioxidant agent and for integrated pest management in agriculture. The research highlights the value of hydrosols in the EO industry and their potential applications in natural product formulations and pest control strategies.\u0000","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":" 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140992702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytotherapeutic Effects of Ashanti Pepper and Horn of Plenty in Sleep Disorder Management Resulting from Stress-Induced Neurobehavioral Alterations","authors":"Akingbesote Oluwaseun, Sule Salawu, Bashorun Justina","doi":"10.11648/j.ijpc.20241001.11","DOIUrl":"https://doi.org/10.11648/j.ijpc.20241001.11","url":null,"abstract":"This investigation explores the potential antidepressant effects arising from the inherent bioactive compounds found in <i>Cnestis ferruguinea</i> and <i>Piper guineense</i>. Both botanical entities contain flavonoids, phenolics, saponins, and tannins, which are known for their anxiolytic, antidepressant, and antioxidant properties. It is worth noting that <i>Cnestis ferruguinea</i> also contains terpenoids, which are recognized for their anxiolytic effects. Given the growing interest in nutritional interventions for neuropsychiatric conditions, our study meticulously examines the antioxidant capacities and anxiolytic properties of these phytochemicals, positioning them as potential regulators of brain health, particularly in the realm of sleep disorders. In response to the increasing demand for therapeutic alternatives with reduced side effects, our inquiry thoroughly examines the antioxidant and anxiolytic profiles of these botanical extracts. Of particular importance, <i>Cnestis ferruguinea</i> exhibits superior antioxidant potential compared to <i>Piper guineense</i>, thus warranting further investigation into its pharmacological utility. Subsequent analysis of the effects of <i>Cnestis ferruguinea</i> on sleep architecture, especially in the context of chronic stress, reveals promising results. The botanical extract significantly prolongs sleep duration in rats exposed to stress, suggesting a potential dual role in mitigating stress-induced neurobehavioral changes and depressive symptoms. Additionally, a noticeable decrease in immobility duration in the forced swim test, along with improvements in acetylcholinesterase levels following <i>Cnestis ferruguinea</i> treatment, provides mechanistic insights into its antidepressant effects. Our findings provide substantial evidence to support the pharmacotherapeutic potential of <i>Cnestis ferruguinea</i>, highlighted by its antioxidant abilities and anxiolytic effects. Further investigations should delve into the intricate molecular pathways underlying these effects, potentially paving the way for innovative botanical-based interventions in neuropsychiatric disorders, particularly those associated with stress-induced neurobehavioral changes and sleep disorders.\u0000","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"218 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Analytical Parameters of Some 2-arylvinyl Benzimidazole Derivatives by Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC/MS/MS)","authors":"Nina Carine Ablé, Deto Ursul Jean-Paul N’guessan, Mariette Désirée Yéhé, Songuigama Coulibaly, Jean-Kisito Kouamé, Claude Bérenger Ngalemo Ngantchouko, Laurent Kipré Séri, Aïsséta Kourouma, Gildas Komenan Gbassi","doi":"10.11648/j.ijpc.20230905.12","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230905.12","url":null,"abstract":"","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"56 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139251479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from &amp;lt;i&amp;gt;C. roseus&amp;lt;/i&amp;gt;, &amp;lt;i&amp;gt;L. multiflora&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;P. amarus,&amp;lt;/i&amp;gt; Beninese Medicinal Plants Used Against Diabetes","authors":"Simplice Koudjina, Alban Gouton Houngbeme, Israël Dossou Paulin Agbogba, Guy Yacolé Sylvain Atohoun, Joachim Djimon Gbenou","doi":"10.11648/j.ijpc.20230905.11","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230905.11","url":null,"abstract":"","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135252322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Black Cumin (&amp;lt;i&amp;gt;Nigella sativa L.L.&amp;lt;/i&amp;gt;L.) Seeds on Some Fluconazole-Resistant and Biofilm-Forming Genes on Strains of &amp;lt;i&amp;gt;Candida albicans strains (C1, C2, CAF2 and CAI4)&amp;lt;/i&amp;gt;","authors":"Hadiza Idi Ali, Zahra’u Umar, Nkechi Eucharia Egbe, Muhammad Sani Abdulsalami","doi":"10.11648/j.ijpc.20230904.12","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230904.12","url":null,"abstract":"The rise in drug resistance has become a serious health issue globally; as such the world health organization has since 1981 encouraged nations on the search for phytomedicines. <i>Nigella sativa</i> L. extracts have been widely studied and proved effective in the treatment of both metabolic and infectious diseases. This study was carried out to determine the effect of black cumin seeds (<i>Nigella sativa</i> L.) at molecular level (fluconazole-resistant genes in <i>Candida albicans</i>’ strains). Aqueous and metabolic extracts of the <i>N sativa</i> were prepared, while the oil extract was obtained from herbal shop and their phytochemical contents were determined. <i>Candida albicans </i>strains <I>C1</I> (wild type), <I>C2</I> a randomly selected clinical isolate and <I>CAI4</I> and <I>CAF2</I> (homogenous and heterogenous <I>URA </I>gene deficient respectively) strains were used for this study. 28 out of 50 (56%) <i>Candida</i> <i>albicans</i> isolated from HVS of suspected PID patients and 3 laboratory strains were resistant to fluconazole. Fluconazole resistance pattern and mode of action of each extract on the different strains were studied. Genes implicated in antifungal resistance and biofilm formation in <i>C. albicans </i>(<I>EGR11, MDS3 </I>and <I>MDR1) </I>were amplified (PCR), and the effects of the three extracts of <i>N. sativa</i> on the genes were studied. The aqueous extract had the highest concentrations of the phytochemicals followed by the methanolic extract and then the oil. The aqueous and methanolic extracts were found to have fungicidal effect at 100mg/ml and 250mg/ml respectively and oil at 100% only. While the oil and some concentration of the methanolic extracts have fungistatic effects. <I>CAI4 </I>and <I>CAF2</I>strains showed resistance to all the concentrations of the aqueous and methanolic extracts. The PCR result showed variation genes implicated in stress and pathogenicity, they were modulated on exposure to the plant extracts. It is recommended that the aqueous and oil of <i>N. sativa</i> be used in the treatment of multidrug resistant <i>Candida</i> infections alongside conventional antimicrobials. More extensive study should be carried out on the effect of the seed extracts of <i>N. sativa</i> on <I>CAF2</I> strains <I>CAI4 </I>strains to study then role of <I>URA3</I> gene on antifungal resistanceand mutagenesis in <i>C. albicans</i>.","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135579741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamic Parameters of Fluoxetine Estimated by Group Contribution Method","authors":"Zhao Mingrui, Peng Peng","doi":"10.11648/j.ijpc.20230904.11","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230904.11","url":null,"abstract":"<i>Background</i>: fluoxetine is a commonly used antidepressant in clinic. There are many synthetic methods, but the total yield is not very high. Physical property data of compounds are often used in scientific research, pharmaceutical process design, chemical and pharmaceutical production, synthesis and resolution of chiral drugs, etc., distinct and accurate estimation of physical property data will greatly save time and effort. In order to provide data support for industrial production of Fluoxetine, the thermodynamic parameters of fluoxetinewere estimated by Joback group contribution method which always used to estimated the thermodynamic parameters of industry product. In particular, thermodynamic parameters such as enthalpy, entropy and heat capacity are state functions, so in practical applications, a state of matter can be arbitrarily chosen as a reference state, and then calculated. Since the melting boiling point is generally related to the structure of the substance, it is found that the measured value is basically consistent with the estimated value by group contribution method. Based on the group contribution method, other thermodynamic properties such as molar melting, standard enthalpy of formation and residual entropy are also estimated to provide data support for the calculation in industrial production. <i>Subjects and Methods</i>: The structure of fluoxetine was divided by Joback group contribution method, and the group contribution value was calculated to get the standard enthalpy of formation, Standard molar isobaric heat capacity, and residual entropy of Fluoxetine. <i>Results</i>: the standard formation enthalpy of fluoxetineis202.09 kJ•mol^-1, standard molar isobaric heat capacity of fluoxetineis 54590 J•mol^-1•K^-1, and residual entropy of fluoxetineis 261.5 J•mol^-1•K^-1. The melting temperature of fluoxetinewas also estimated by Joback group contribution method at 825.94 K, which measured by experiment is 158°C, or 456 K, with average relative error ARD = 8.11%. The boiling point temperature of fluoxetine was estimated by Joback method is 733.87 K, which was 569.2°C (867.35K) by measured. The average relative error ARD is 15.38%. <i>Conclusions</i>: The results show that the thermodynamic parameters of fluoxetine can be estimated by Joback group contribution method. Joback method has a high accuracy in estimating the boiling point of Fluoxetine, and it quite fit with the melting point after revised.","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135785837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hurdle Technology – Approaches to Improve Cosmetic Preservation","authors":"S. Athar, Anjali Gholap, R. Rastogi","doi":"10.11648/j.ijpc.20230903.12","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230903.12","url":null,"abstract":": Increasing toxicity reports and new regulations for existing preservatives has driven a need for cosmetic formulations that are self-preserved. Use of preservatives is important to ascertain shelf life stability and minimize contamination after opening. While new classes of materials are being researched, their efficacy has been found to be substantially lower than their predecessors. Due to the variety of formulation types, it is exceedingly challenging to preserve different product formats using a handful of preservatives. Hurdle technology is being adapted by cosmetic scientists for designing formulations by modifying physico-chemical properties and use of multi-functional ingredients with antimicrobial properties to improve shelf life and minimize in-use contamination of products. This technology will also assist formulation scientists to make “preservative-free” claims for products while consumers get the advantage of using “clean cosmetics”. Further, multifunctional materials help in reducing the formulation cost while enhancing product stability due to lesser number of ingredients. In this focussed review, we describe various techniques for improving preservation with their strengths and weaknesses to assist formulation scientists in making informed choices. Implementation of these methods with new preservatives will provide solutions to scientists to manage the diverse range of formulations for various benefits","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86380370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protection of Vine from Winter Stress with the Use of Silicate","authors":"S. Lepeshkina, Uri Yakuba","doi":"10.11648/j.ijpc.20230903.11","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230903.11","url":null,"abstract":"","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85831495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Quality Management (TQM): A Need of Industry for Quality Product","authors":"Amol Sampat Deshmukh, Pravin Rangnath Dighe, Suvarna Jagannath Shelke","doi":"10.11648/j.ijpc.20230902.12","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230902.12","url":null,"abstract":"","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78158659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Media as a Tool for Professional Development, Advancement and Presentation of Pharmacist Expanded Roles","authors":"Muhammad Ahmer Raza, Shireen Aziz, Adili Tuersun, Misbah Noreen, Muhammad Zain Iqbal, Danyal Iftikhar","doi":"10.11648/j.ijpc.20230902.11","DOIUrl":"https://doi.org/10.11648/j.ijpc.20230902.11","url":null,"abstract":"","PeriodicalId":14230,"journal":{"name":"International Journal of Pharmacy and Chemistry","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}