Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120109
Dan Ginting, A. Rachman, L. Adenin, R. L. Kusumawati, Mirzan Hasibuan, Harry A. Asroel, Y. Herwanto
Backgrounds: Tonsillitis is the most common disease in otorhinolaryngology both acute and chronic, especially in children. Recurrent tonsillitis is a chronic inflammatory process in the palatine tonsils. Several studies have shown differences in pathogenic flora on surface and tonsillar core. This also causes an increase failure of eradicating germs in acute tonsillitis. Therefore, it falls into chronic stage. Identifying the bacterial organism in acute tonsillitis will guide appropriate antibiotic therapy that can revolutionize the management of chronic tonsillitis.Objectives: To determine the bacteria pattern from surface and tonsillar core in patients with recurrent tonsillitis. Methods: The research is a descriptive with cross sectional study. The sample of the study was patients with recurrent tonsillitis who underwent tonsillectomy surgery at Adam Malik General Hospital Medan and several satellite hospitals in Medan that met the inclusion criterias. Results:This study was attended by 33 recurrent tonsillitis subjects with more male(66,7%) and most of them below 20 years (66.7%).The most type of aerobic bacteria from surface and tonsillar core swabs was Staphylococcus aureus. Antibiotics that are still sensitive to Staphylococcus aureus in tonsillar core swabs are Gentamycin, Tigecycline, Clindamycin, and Inezolid. Antibiotics that are still sensitive to Staphylococcus aureus on surface smears are Tigecycline, Vancomycin, and Erythromycin. The bacteria form surface did not present bacteria from tonsillar core. The most anaerobic bacteria found on both ofthe surface and tonsillar core were Bacteroides fragilis.Conclusions:The swab cultures taken from the tonsillar surface may not always reveal the real pathogen of the tonsils. In addition, the estimated probability of tonsillar bacteriology by surface swabs varies with the type of the pathogen.
{"title":"Bacteria Pattern Aerobic and Anaerobic From Surface Swab and Tonsillar Core Culture in Patients With Recurrent Tonsillitis","authors":"Dan Ginting, A. Rachman, L. Adenin, R. L. Kusumawati, Mirzan Hasibuan, Harry A. Asroel, Y. Herwanto","doi":"10.20902/ijptr.2019.120109","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120109","url":null,"abstract":"Backgrounds: Tonsillitis is the most common disease in otorhinolaryngology both acute and chronic, especially in children. Recurrent tonsillitis is a chronic inflammatory process in the palatine tonsils. Several studies have shown differences in pathogenic flora on surface and tonsillar core. This also causes an increase failure of eradicating germs in acute tonsillitis. Therefore, it falls into chronic stage. Identifying the bacterial organism in acute tonsillitis will guide appropriate antibiotic therapy that can revolutionize the management of chronic tonsillitis.Objectives: To determine the bacteria pattern from surface and tonsillar core in patients with recurrent tonsillitis. Methods: The research is a descriptive with cross sectional study. The sample of the study was patients with recurrent tonsillitis who underwent tonsillectomy surgery at Adam Malik General Hospital Medan and several satellite hospitals in Medan that met the inclusion criterias. Results:This study was attended by 33 recurrent tonsillitis subjects with more male(66,7%) and most of them below 20 years (66.7%).The most type of aerobic bacteria from surface and tonsillar core swabs was Staphylococcus aureus. Antibiotics that are still sensitive to Staphylococcus aureus in tonsillar core swabs are Gentamycin, Tigecycline, Clindamycin, and Inezolid. Antibiotics that are still sensitive to Staphylococcus aureus on surface smears are Tigecycline, Vancomycin, and Erythromycin. The bacteria form surface did not present bacteria from tonsillar core. The most anaerobic bacteria found on both ofthe surface and tonsillar core were Bacteroides fragilis.Conclusions:The swab cultures taken from the tonsillar surface may not always reveal the real pathogen of the tonsils. In addition, the estimated probability of tonsillar bacteriology by surface swabs varies with the type of the pathogen.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75705883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120205
N. Mathew, A. Siddiq
{"title":"A Study on Magnitude and Pattern of Blood Pressure and Prevalence of Obesity among Diabetes Patients","authors":"N. Mathew, A. Siddiq","doi":"10.20902/IJPTR.2019.120205","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120205","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83125884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surgical suture is a medical device used to hold body tissues together after an injury or surgery. Application generally involves using a needle with an attached length of thread as evaluated for the potential to cause delayed skin contact sensitization in a Closed-patch test. This study was conducted base on the requirements of ISO 10993-10: Biological Evaluation of Medical Devices-Part 10: Tests for Irritation and Skin Sensitization. The guinea pig maximization test (GPMT) is made of the potential of the material under test to produce skin sensitization. The polar and nonpolar extracts were prepared by using saline solution and olive oil, respectively, after sinking the materials tested (2.0 g) in 10 ml of the corresponding liquid. Incubation was carried out at the temperature of 37 °C for 72 h. The saline solution and pure olive oil were used as negative control samples and were incubated under the same conditions as above. The guinea pig maximization test (GPMT) consist of intradermal induction phase, topical induction patches and challenge phase. Following a intradermal induction phase, The test item extract with polar and non polar solvent were injected in clipping area of each animal in test group and control group, respectively. Following a challenge phase, the test group and control group were challenged with the test item. No evidence of sensitization was observed. Individual results of skin scoring for the induction phase and the challenge phase is 0.0. Keyword : Surgical suture,Intravenous reactivity test. Introduction Polymeric materials have dramatically influenced our day to day life. They find potential in various fields like food packaging, automobiles, water purification etc. [1-3] Application of polymeric biomaterials in medicine has been a thrust area of research owing to the exceptional and superior properties they exhibit. [4] The increased use of polymeric biomaterials in the form of surgical implants, sutures and scaffolds for biomedical applications. [5] Tangthong Jiraporn et al /International Journal of PharmTech Research, 2019,12(1): 90-95. DOI: http://dx.doi.org/10.20902/IJPTR.2019.120112 International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455-9563 Vol.12, No.01, pp 90-95, 2019 Tangthong Jiraporn et al /International Journal of PharmTech Research, 2019,12(1): 90-95. 91 Surgical suture is a medical device used to hold body tissues together after an injury or surgery. Application generally involves using a needle with an attached length of thread. A number of different shapes, sizes, and thread materials have been developed over its millennia of history. Surgeons, physicians, dentists, podiatrists, eye doctors, registered nurses and other trained nursing personnel, medics, and clinical pharmacists typically engage in suturing. Surgical knots are used to secure the sutures. [6] The primary purpose of suture is to hold apposing tissues together to facilitate and hasten healing p
外科缝合是一种医疗设备，用于在受伤或手术后将身体组织固定在一起。在封闭贴片试验中，应用通常涉及使用一根附有线长度的针，以评估引起延迟皮肤接触致敏的可能性。本研究是根据ISO 10993-10的要求进行的:医疗器械的生物评价-第10部分:刺激和皮肤致敏试验。豚鼠最大化试验(GPMT)是由被试材料产生皮肤致敏的潜力组成的。极性提取物和非极性提取物分别用生理盐水和橄榄油制备，将被测材料(2.0 g)沉在10ml相应的液体中。37℃孵育72h，以生理盐水和纯橄榄油为阴性对照，同上条件孵育。豚鼠最大化试验(GPMT)包括皮内诱导期、局部诱导贴片和激发期。经皮内诱导后，试验组和对照组分别在每只动物的剪断区注射极性溶剂和非极性溶剂提取物。在挑战阶段之后，实验组和对照组分别接受测试项目的挑战。没有观察到致敏的证据。诱导阶段和刺激阶段的个体皮肤评分为0.0。关键词:外科缝合;静脉反应性试验;高分子材料极大地影响了我们的日常生活。它们在食品包装、汽车、水净化等各个领域都有潜力[1-3]，高分子生物材料在医学上的应用一直是研究的重点领域，因为它们表现出卓越的性能。[4]高分子生物材料在外科植入物、缝合线和生物医学支架中的应用越来越多。[5]张晓明，等。中药复方制剂的研究进展[j] .中国药理学杂志，2015,31(1):90-95。DOI: http://dx.doi.org/10.20902/IJPTR.2019.120112 International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455-9563 Vol.12, No.01, pp 90-95, 2019唐彤等/International Journal of PharmTech Research, 2019,12(1): 90-95。外科缝合是一种医疗器械，用于在受伤或手术后将身体组织固定在一起。应用通常涉及到使用一根附有一段线的针。在几千年的历史中，许多不同的形状，大小和螺纹材料已经发展起来。外科医生、内科医生、牙医、足科医生、眼科医生、注册护士和其他训练有素的护理人员、医务人员和临床药剂师通常从事缝合工作。手术结用于固定缝合线。[6]缝合的主要目的是在受伤或外科手术后将相邻组织固定在一起，以促进和加速愈合过程，尽量减少或不形成疤痕。[7]过去，各种各样的材料，如金、银、铁、钢丝、干动物内脏、动物毛(如马毛)、丝绸、树皮和植物纤维(如亚麻、棉花)被用作缝合材料，其中一些仍在使用。近年来，人们使用各种合成生物材料，如聚二氧环酮、聚乳酸-羟基乙酸等作为缝合材料。[8]为了尽量减少对患者的任何潜在危害，必须对医疗器械中使用的聚乙醇酸- co - l -丙交酯制成的手术缝合线进行生物相容性评估。常用测试用于测量生物相容性:ISO10993-10，医疗器械生物学评价(2010)。[9]动物和畜牧业白化邓金哈特利豚鼠已被用于致敏研究。将测试项目重复贴片到被剪断的完整皮肤上。局部应用与人体暴露途径有关，并允许评估皮肤接触和/或潜在敏化的吸收。可以直接观察局部应用部位下的反应。根据国际标准化组织10993-2《医疗器械生物学评价第2部分》的试验指南进行动物和畜牧业试验:动物福利要求，2006[10]，国际标准化组织10993-10，医疗器械生物学评价第10部分刺激性和延迟型超敏反应试验，2010[9]和《实验动物护理和使用指南》(实验动物资源研究所，国家学术出版社2011;NIH出版号#85-23,2011年修订)。健康幼年豚鼠，体重300 ~ 500 g，购自泰国玛希隆大学NLAC实验动物生产办公室。 动物在标准条件下12:12(明暗循环)，温度22±30℃，相对湿度30-70%。这些动物被单独关在笼子里。这些动物被随意喂食饲料和氯化水。所有动物在试验前均进行了5 d的环境适应。本研究由玛希隆大学国家实验动物中心动物护理和使用委员会(NLAC-ACUC)批准;泰国。手术缝合线(聚乙二醇酯- co - l -丙交酯)和对照品制备依据国际标准化组织10993-12《医疗器械生物学评价-第12部分:样品制备和参考物质》2007年的试验指南进行。[11]对照品为极性溶剂(生理盐水)和非极性溶剂(橄榄油)。在极性溶剂和非极性溶剂中提取2克手术缝合线(聚乙二醇- co - l -丙交酯)。37℃水浴72小时。以极性溶剂和与手术缝线无接触的非极性溶剂为阴性对照，在同上条件下孵育。提取液在4小时内使用，进行测试程序。[11]皮内诱导期在暴露前16 - 24小时用电夹子剪断每只动物背部的皮毛。暴露当天，将每只动物的夹片区分成2个部位。试验部位和对照部位分别采用皮内(皮内)手术缝合线(聚乙二醇酯- co - l -丙交酯)提取和对照项目。唐彤等/国际医药技术研究杂志，2019,12(1):90-95。92试验组和对照组动物在剪断部位皮内注射0.1 ml。注射部位(A、B、C)为A点:将体积比为50:50的弗氏完全佐剂与溶剂混合，并以0.9%氯化钠为水溶性物质的稳定乳液。B点:实验动物注射实验项目提取物，对照动物单独注射溶剂。站点C:实验动物注射以体积比为50:50的弗氏完全佐剂稳定乳剂与溶剂稀释的试验项目萃取物。对照动物注射加佐剂的空白液乳状液。局部诱导期皮内诱导期结束后第7天，用电钳剪断试验组和对照组的毛发。所有实验动物和对照动物通过局部应用于每只动物的囊内区域，使用一个贴片施用试验项目。局部诱导前24+2小时，将10%十二烷基硫酸钠按摩于皮肤。选择B位点的浓度应用于囊内区域。48+1小时后取出贴片。
{"title":"Biocompatibility Assessments of Surgical sutures: The Guinea Pig Maximization Test","authors":"Tangthong Jiraporn, Jatavattana Masupa, Amted Nanthana, Sirimontaporn Aunchalee, Srimangkornkaew Passaraporn","doi":"10.20902/IJPTR.2019.120112","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120112","url":null,"abstract":"Surgical suture is a medical device used to hold body tissues together after an injury or surgery. Application generally involves using a needle with an attached length of thread as evaluated for the potential to cause delayed skin contact sensitization in a Closed-patch test. This study was conducted base on the requirements of ISO 10993-10: Biological Evaluation of Medical Devices-Part 10: Tests for Irritation and Skin Sensitization. The guinea pig maximization test (GPMT) is made of the potential of the material under test to produce skin sensitization. The polar and nonpolar extracts were prepared by using saline solution and olive oil, respectively, after sinking the materials tested (2.0 g) in 10 ml of the corresponding liquid. Incubation was carried out at the temperature of 37 °C for 72 h. The saline solution and pure olive oil were used as negative control samples and were incubated under the same conditions as above. The guinea pig maximization test (GPMT) consist of intradermal induction phase, topical induction patches and challenge phase. Following a intradermal induction phase, The test item extract with polar and non polar solvent were injected in clipping area of each animal in test group and control group, respectively. Following a challenge phase, the test group and control group were challenged with the test item. No evidence of sensitization was observed. Individual results of skin scoring for the induction phase and the challenge phase is 0.0. Keyword : Surgical suture,Intravenous reactivity test. Introduction Polymeric materials have dramatically influenced our day to day life. They find potential in various fields like food packaging, automobiles, water purification etc. [1-3] Application of polymeric biomaterials in medicine has been a thrust area of research owing to the exceptional and superior properties they exhibit. [4] The increased use of polymeric biomaterials in the form of surgical implants, sutures and scaffolds for biomedical applications. [5] Tangthong Jiraporn et al /International Journal of PharmTech Research, 2019,12(1): 90-95. DOI: http://dx.doi.org/10.20902/IJPTR.2019.120112 International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455-9563 Vol.12, No.01, pp 90-95, 2019 Tangthong Jiraporn et al /International Journal of PharmTech Research, 2019,12(1): 90-95. 91 Surgical suture is a medical device used to hold body tissues together after an injury or surgery. Application generally involves using a needle with an attached length of thread. A number of different shapes, sizes, and thread materials have been developed over its millennia of history. Surgeons, physicians, dentists, podiatrists, eye doctors, registered nurses and other trained nursing personnel, medics, and clinical pharmacists typically engage in suturing. Surgical knots are used to secure the sutures. [6] The primary purpose of suture is to hold apposing tissues together to facilitate and hasten healing p","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88976469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120210
P. Mohite, D. Pawar
{"title":"In silico Prioritization of some Tetrazole Chalcones for Anticonvulsant Activity","authors":"P. Mohite, D. Pawar","doi":"10.20902/ijptr.2019.120210","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120210","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88822805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120301
W. Permadi, H. Syam, H. Bayuaji, T. Madjid, B. Irsyad
{"title":"Securinega leucopyrus The Effect of Mobile Phone Radiation on Sperm DNA Fragmentation","authors":"W. Permadi, H. Syam, H. Bayuaji, T. Madjid, B. Irsyad","doi":"10.20902/ijptr.2019.120301","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120301","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88105072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120407
V. Patel, N. Acharya
Macrotyloma uniflorum Linn. (Fabaceae) seeds are widely used for their diuretic and urolithiatic effects in India. The present study investigated the effect of aqueous extract of Macrotyloma uniflorum seeds (AEMU) on ethylene glycol induced urolithiasis in rats. To induce urolithiasis, 0.75% v/v ethylene glycol was administered orally for 14 days. The curative doses of 400 and 800 mg/kg were administered from 15th to 28th day. On 28th day, 24 hr urine, serum was collected and various biochemical parameters were estimated in urine, serum and kidney homogenate along with histology of kidney. Co-administration of AEMU with ethylene glycol has significantly (p<0.001) increased the urine volume and the level of calculus inhibitors like magnesium, citrate and decreased the level of calculus promoters like calcium, oxalate, uric acid and urea also decreased in crystallria in urine. AEMU supplement also prevented the pathological changes in kidney and increased the glomerulus activity of the kidney. These results indicate that AEMU showed significant activity in urolithiasis which might be due to its diuretic, calcium oxalate crystal formation inhibitory effects and its ability to increase the levels of inhibitors and decrease the level of promoters of urolithiasis.
{"title":"Effect of Macrotyloma uniflorum seeds in ethylene glycol\u0000induced urolithiasis in rats","authors":"V. Patel, N. Acharya","doi":"10.20902/ijptr.2019.120407","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120407","url":null,"abstract":"Macrotyloma uniflorum Linn. (Fabaceae) seeds are widely used for their diuretic and urolithiatic effects in India. The present study investigated the effect of aqueous extract of Macrotyloma uniflorum seeds (AEMU) on ethylene glycol induced urolithiasis in rats. To induce urolithiasis, 0.75% v/v ethylene glycol was administered orally for 14 days. The curative doses of 400 and 800 mg/kg were administered from 15th to 28th day. On 28th day, 24 hr urine, serum was collected and various biochemical parameters were estimated in urine, serum and kidney homogenate along with histology of kidney. Co-administration of AEMU with ethylene glycol has significantly (p<0.001) increased the urine volume and the level of calculus inhibitors like magnesium, citrate and decreased the level of calculus promoters like calcium, oxalate, uric acid and urea also decreased in crystallria in urine. AEMU supplement also prevented the pathological changes in kidney and increased the glomerulus activity of the kidney. These results indicate that AEMU showed significant activity in urolithiasis which might be due to its diuretic, calcium oxalate crystal formation inhibitory effects and its ability to increase the levels of inhibitors and decrease the level of promoters of urolithiasis.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83321562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120107
Sanjay Sharma, Sarvesh Paliwal, V. Singhai
Background: Immediate release formulation of Hydrochlorothiazide is available in market. Cmax achieved at 2 h, duration of action persist for 6-12 h, resulting in multiple dosing to maintain plasma concentration and in vivo activity. Objective: The objective of research work was to design modified release tablets of Hydrochlorothiazide 25 mg with the intention of once a day dosing. Cmax will achieve after 10 to 12 h of administration. This controlled release will constantly induce diuretic activity for whole night and day especially during early morning hours, resulting in decreased blood volume, reduced cardiac output and controlled blood pressure. When patient awakes up in morning, blood pressure will be comparatively low thus reducing the frequency of cardiac arrest.Method: Here an attempt has been made to kinetically calculate required in-vitro dissolution profile by deconvolution method using Wagner–nelson equation. Plasma concentration time profile of immediate release tablet 12.5 mg is available in literature and that of modified release formulation 25 mg is calculated such that Area under curve of modified release tablet matches with that of two immediate release tablets of 12.5 mg along with Cmax and Kel, thus meeting the criteria for bio-equivalency. Tmax will be delayed from 2 h to approximately 10 h. Results: In-vivo dissolution profile is calculated from the equation of “fraction of drug absorbed”. Perfect IVIVC is matched when value of slope is 1, intercept is 0 and correlation coefficient (R 2 ) 0.99. Conclusion: This in-vitro profile will be used further to develop modified release formulation.
{"title":"In vitro Drug Release Prediction of Hydrochlorothiazide Modified Release Tablet using Wagner Nelson Method and Deconvolution Approach","authors":"Sanjay Sharma, Sarvesh Paliwal, V. Singhai","doi":"10.20902/IJPTR.2019.120107","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120107","url":null,"abstract":"Background: Immediate release formulation of Hydrochlorothiazide is available in market. Cmax achieved at 2 h, duration of action persist for 6-12 h, resulting in multiple dosing to maintain plasma concentration and in vivo activity. Objective: The objective of research work was to design modified release tablets of Hydrochlorothiazide 25 mg with the intention of once a day dosing. Cmax will achieve after 10 to 12 h of administration. This controlled release will constantly induce diuretic activity for whole night and day especially during early morning hours, resulting in decreased blood volume, reduced cardiac output and controlled blood pressure. When patient awakes up in morning, blood pressure will be comparatively low thus reducing the frequency of cardiac arrest.Method: Here an attempt has been made to kinetically calculate required in-vitro dissolution profile by deconvolution method using Wagner–nelson equation. Plasma concentration time profile of immediate release tablet 12.5 mg is available in literature and that of modified release formulation 25 mg is calculated such that Area under curve of modified release tablet matches with that of two immediate release tablets of 12.5 mg along with Cmax and Kel, thus meeting the criteria for bio-equivalency. Tmax will be delayed from 2 h to approximately 10 h. Results: In-vivo dissolution profile is calculated from the equation of “fraction of drug absorbed”. Perfect IVIVC is matched when value of slope is 1, intercept is 0 and correlation coefficient (R 2 ) 0.99. Conclusion: This in-vitro profile will be used further to develop modified release formulation.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88803078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120111
R. Mohamed, A. Sherief, E. Mohamed
Objectives: To compare the effects of whole body vibration with suspension therapy in relation to balance and functional capacity in diplegic cerebral palsied children. Subjects and methods: Thirty diplegic cerebral palsied children of both sexes were enrolled in the study with their ages ranged between 7 and 9 years. They were randomly and equally distributed into two study groups. The first group underwent the whole body vibration training and second group underwent suspension therapy through the spider cage. Also, both groups received the same designed physical therapy program. Stability indices and functional capacity were evaluated by using 6-minute walk test and Biodex stability system respectively before and after six successive months of treatment. Results: significant differences were obtained when comparing the pre and post treatment results of all measuring variables of both groups showed (P <0.05) except non-significant differences in medio-lateral stability index (P >0.05) in group I. Also, the results showed that the group underwent the suspension had more effect in comparison to the group of whole body vibration. Conclusion: Whole body vibration and suspension therapy training are effective additional tools in rehabilitation of diplegic cerebral palsied children with decreased balance and functional capacity in favor of the suspension therapy.
{"title":"Effect of Whole Body Vibration versus Suspension Therapy on Balance and Functional Capacity in Children with Diplegic Cerebral Palsy","authors":"R. Mohamed, A. Sherief, E. Mohamed","doi":"10.20902/ijptr.2019.120111","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120111","url":null,"abstract":"Objectives: To compare the effects of whole body vibration with suspension therapy in relation to balance and functional capacity in diplegic cerebral palsied children. Subjects and methods: Thirty diplegic cerebral palsied children of both sexes were enrolled in the study with their ages ranged between 7 and 9 years. They were randomly and equally distributed into two study groups. The first group underwent the whole body vibration training and second group underwent suspension therapy through the spider cage. Also, both groups received the same designed physical therapy program. Stability indices and functional capacity were evaluated by using 6-minute walk test and Biodex stability system respectively before and after six successive months of treatment. Results: significant differences were obtained when comparing the pre and post treatment results of all measuring variables of both groups showed (P <0.05) except non-significant differences in medio-lateral stability index (P >0.05) in group I. Also, the results showed that the group underwent the suspension had more effect in comparison to the group of whole body vibration. Conclusion: Whole body vibration and suspension therapy training are effective additional tools in rehabilitation of diplegic cerebral palsied children with decreased balance and functional capacity in favor of the suspension therapy.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81262237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120212
M. Sahithi, B. Gurupadayya
{"title":"Determination of Lamivudine by Precolumn Derivatisation using GC-FID in Pure and Pharmaceutical Dosage Form","authors":"M. Sahithi, B. Gurupadayya","doi":"10.20902/IJPTR.2019.120212","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120212","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90115526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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