Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120401
Agussalim salim, Nazar Moesbar, Andriandi
Objective-Giant Cell Tumors (GCT) in bone is a rare musculoskeletal tumor. The purpose of this study was to study the characteristics of patients with Giant Cell Tumors in RSUP. Haji Adam Malik for 2013- 2018. Materials and Methods-The type of research conducted is a retrospective descriptive research method. This research was conducted in RSUP. Adam Malik Haji Medan based on medical records of patients with Giant Cell Tumors during the period of January 2013 - December 2018. The collected medical and demographic data is tabulated and presented in the form of a frequency distribution chart or table and analyzed in full. Data analysis used in this study uses total sampling which is presented in the form of tables or diagrams.Results-During the period of the study taken from the medical record data of Medan Haji Adam Malik Hospital, 37 patients with Giant Cell Tumors were treated. Distribution of the number of sample subjects with diagnoses of giant cell tumors of male sex as many as 19 patients (51.3%) while female sex numbered 18 patients (48.6%). Based on the location of giant cell tumors obtained by distal radius of 3 patients (8.1%), femur as many as 9 patients (24.3%), fibula as many as 2 patients (5.4%), proximal tibia as many as 14 patients (37 , 9)%), then in categories other than long bones (digiti) as many as 5 patients (13.5%), patella as many as 2 patients (5.4%), and pedis as many as 2 patients (5.4%). Based on the actions taken, as many as 21 people (56.7%) carried out extensive excision, curettage + bone cement as many as 11 people (29.7%), amputation in 3 patients (8.1%), ORIF + bone grafts by 2 people (5.5%). In this study, of 37 patients with giant cell tumors with stage 1 no patients, stage 2 as many as 12 people (32.4%), stage 3 as many as 25 people (67.5%).Conclusion- Patients with tumor giant cells were found at productive age, there was not much difference in sex, the most campanacci stage was in stage 3, the most common sites were proximal to the tibia, the most extensive measures were also available, and metastases were not available to other organs.
目的:骨巨细胞瘤(GCT)是一种罕见的肌肉骨骼肿瘤。本研究的目的是研究RSUP中巨细胞肿瘤患者的特征。哈吉亚当马利克2013-2018。材料和方法-所进行的研究类型是回顾性描述性研究方法。这项研究在RSUP进行。Adam Malik Haji Medan基于2013年1月至2018年12月期间巨细胞肿瘤患者的医疗记录。收集到的医疗和人口统计数据以频率分布图或表格的形式制成表格，并进行全面分析。本研究中使用的数据分析采用总抽样，以表格或图表的形式呈现。结果:研究期间，棉兰Haji AdamMalik医院的病历资料显示37例巨细胞瘤患者接受治疗。诊断为巨细胞瘤的样本受试者中，男性19例(51.3%)，女性18例(48.6%)。根据巨细胞肿瘤的位置，桡骨远端3例(8.1%)，股骨9例(24.3%)，腓骨2例(5.4%)，胫骨近端14例(37.9%)，非长骨(指)5例(13.5%)，髌骨2例(5.4%)，足部2例(5.4%)。根据所采取的措施，广泛切除21例(56.7%)，刮除+骨水泥11例(29.7%)，截肢3例(8.1%)，ORIF +骨移植2例(5.5%)。本研究中37例巨细胞瘤患者中，1期无患者，2期多达12人(32.4%)，3期多达25人(67.5%)。结论:肿瘤巨细胞多发于生育年龄，性别差异不大，坎帕那契期以3期多见，部位以胫骨近端最常见，治疗措施也最广泛，未发生其他脏器转移。
{"title":"The Characteristics of Patients With Giant Cell Tumors in\u0000General Hospital of Haji Adam Malik Medan In 2013-2018","authors":"Agussalim salim, Nazar Moesbar, Andriandi","doi":"10.20902/ijptr.2019.120401","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120401","url":null,"abstract":"Objective-Giant Cell Tumors (GCT) in bone is a rare musculoskeletal tumor. The purpose of this study was to study the characteristics of patients with Giant Cell Tumors in RSUP. Haji Adam Malik for 2013- 2018. Materials and Methods-The type of research conducted is a retrospective descriptive research method. This research was conducted in RSUP. Adam Malik Haji Medan based on medical records of patients with Giant Cell Tumors during the period of January 2013 - December 2018. The collected medical and demographic data is tabulated and presented in the form of a frequency distribution chart or table and analyzed in full. Data analysis used in this study uses total sampling which is presented in the form of tables or diagrams.Results-During the period of the study taken from the medical record data of Medan Haji Adam Malik Hospital, 37 patients with Giant Cell Tumors were treated. Distribution of the number of sample subjects with diagnoses of giant cell tumors of male sex as many as 19 patients (51.3%) while female sex numbered 18 patients (48.6%). Based on the location of giant cell tumors obtained by distal radius of 3 patients (8.1%), femur as many as 9 patients (24.3%), fibula as many as 2 patients (5.4%), proximal tibia as many as 14 patients (37 , 9)%), then in categories other than long bones (digiti) as many as 5 patients (13.5%), patella as many as 2 patients (5.4%), and pedis as many as 2 patients (5.4%). Based on the actions taken, as many as 21 people (56.7%) carried out extensive excision, curettage + bone cement as many as 11 people (29.7%), amputation in 3 patients (8.1%), ORIF + bone grafts by 2 people (5.5%). In this study, of 37 patients with giant cell tumors with stage 1 no patients, stage 2 as many as 12 people (32.4%), stage 3 as many as 25 people (67.5%).Conclusion- Patients with tumor giant cells were found at productive age, there was not much difference in sex, the most campanacci stage was in stage 3, the most common sites were proximal to the tibia, the most extensive measures were also available, and metastases were not available to other organs.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81375782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120403
S. Sujithra
Plant based extracts are attractive sources of nutraceutical which have been shown to produce promising results in the treatment of curing many diseases and disorders. Sesbania grandiflora Linn is one such plant commonly known as Agathi belongs to the family, Fabaceae native to tropical region that has been used medicinally for centuries. The present study deals with bioactive components extraction from the flowers of Sesbania grandiflora using different solvents namely ethanol, methanol, petroleum ether, acetone, and n-hexane using soxhlet apparatus. Response surface methodology is applied to optimize the extraction process of bioactive components from Sesbania grandiflora flower. The effect of process parameters such as temperature (40 0C to 600C), time (8hr to 10hr) and the quantity of sample (10gm to 20gm) on extraction yield was studied. Among the five solvents used in the study, a maximum yield 9.95% was found when ethanol is used. Phytochemical constituents of the extract were analyzed using phytochemical screening methods. The extraction yield is optimized for different process variables using design of experiments.
{"title":"Bioactive Components from Flowers of Sesbania grandiflora\u0000L.: Extraction and Optimization Studies","authors":"S. Sujithra","doi":"10.20902/ijptr.2019.120403","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120403","url":null,"abstract":"Plant based extracts are attractive sources of nutraceutical which have been shown to produce promising results in the treatment of curing many diseases and disorders. Sesbania grandiflora Linn is one such plant commonly known as Agathi belongs to the family, Fabaceae native to tropical region that has been used medicinally for centuries. The present study deals with bioactive components extraction from the flowers of Sesbania grandiflora using different solvents namely ethanol, methanol, petroleum ether, acetone, and n-hexane using soxhlet apparatus. Response surface methodology is applied to optimize the extraction process of bioactive components from Sesbania grandiflora flower. The effect of process parameters such as temperature (40 0C to 600C), time (8hr to 10hr) and the quantity of sample (10gm to 20gm) on extraction yield was studied. Among the five solvents used in the study, a maximum yield 9.95% was found when ethanol is used. Phytochemical constituents of the extract were analyzed using phytochemical screening methods. The extraction yield is optimized for different process variables using design of experiments.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89972416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120410
Hari Irawan, E. Fikri, E. R. Daulay
Background & Objectives: Unspecified lower abdominal pain might confuse clinicians in diagnosing pediatric appendicitis. Ultrasonography, as an initial affordable tool, has been learned its role in reducing unnecessary appendectomy. This study aimed to determine the accuracy of ultrasonography in pediatric acute appendicitis and its correlation to intraoperative findings, confirmed by histopathology results. The result would verify other study experience. Methods : The study was a diagnostic study which retrospectively review the children who underwent an ultrasound study for suspected appendicitis in pediatric surgery division of Haji Adam Malik Hospital and Universitas Sumatera Utara Hospital, Medan, North Sumatera between January 2014 until March 2019. We determined the accuracy along with sensitivity and specificity results of Ultrasonography (USG) using calculated formula. The comparation between ultrasonography results and intraoperative findings was analyzed using Chi Square test or its alternative. Results : Among the 32 patients, male and female were almost equal in 1:1 ratio, with mean age of 14.06 (±3.98) years old. Twenty-six patients were positively diagnosed as appendicitis using ultrasonography. Only two patients have no appendicitis based on intraoperative findings, confirmed by histopathology results. There is a statistically significant difference between ultrasonography findings and histopathology results (p=0,03). We obtained the accuracy of ultrasonography in predicting appendicitis was 87.5%, with 86.7% sensitivity and 100% specificity. Conclusion : Our results compare favorably with alternative studies, however indicate the potential for improvement in accuracy of image, with a future study incorporating new ways of categorizing ultrasound findings presently being undertaken.
{"title":"Accuracy of Findings of Ultrasound (USG) Examination in\u0000Pediatric Patients with suspected Appendicitis with\u0000Intraoperative Findings","authors":"Hari Irawan, E. Fikri, E. R. Daulay","doi":"10.20902/ijptr.2019.120410","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120410","url":null,"abstract":"Background & Objectives: Unspecified lower abdominal pain might confuse clinicians in diagnosing pediatric appendicitis. Ultrasonography, as an initial affordable tool, has been learned its role in reducing unnecessary appendectomy. This study aimed to determine the accuracy of ultrasonography in pediatric acute appendicitis and its correlation to intraoperative findings, confirmed by histopathology results. The result would verify other study experience. Methods : The study was a diagnostic study which retrospectively review the children who underwent an ultrasound study for suspected appendicitis in pediatric surgery division of Haji Adam Malik Hospital and Universitas Sumatera Utara Hospital, Medan, North Sumatera between January 2014 until March 2019. We determined the accuracy along with sensitivity and specificity results of Ultrasonography (USG) using calculated formula. The comparation between ultrasonography results and intraoperative findings was analyzed using Chi Square test or its alternative. Results : Among the 32 patients, male and female were almost equal in 1:1 ratio, with mean age of 14.06 (±3.98) years old. Twenty-six patients were positively diagnosed as appendicitis using ultrasonography. Only two patients have no appendicitis based on intraoperative findings, confirmed by histopathology results. There is a statistically significant difference between ultrasonography findings and histopathology results (p=0,03). We obtained the accuracy of ultrasonography in predicting appendicitis was 87.5%, with 86.7% sensitivity and 100% specificity. Conclusion : Our results compare favorably with alternative studies, however indicate the potential for improvement in accuracy of image, with a future study incorporating new ways of categorizing ultrasound findings presently being undertaken.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78288624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120306
S. Minocha, S. Pahwa
{"title":"Approaches for Solubility enhancement of Floroqunilones(Second Generation) during Scale Up Procedures","authors":"S. Minocha, S. Pahwa","doi":"10.20902/IJPTR.2019.120306","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120306","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77101194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120102
Nenny N. Sitohang, A. Siregar, A. N. Nasution, H. Hasan, Abdul Halim, F. Habib
Background : Coronary heart disease (CHD), a gradual chronic inflammatory disease, is influenced by the environmental, lifestyle, and genetic factors that can be seen from traditional risk factors, inflammatory biomarkers, and metabolic status.Inflammatory biomarkers that were currently being studied include high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα), and intercellular adhesion molecule-1 (ICAM-1). Increased hsCRP is an independent risk factor that is important for CHD and determines the prognosis in patients who have CHD. Cardiac rehabilitation has a role in improving risk factors and preventing a variety of advanced cardiovascular events. This study aims to find the relationship of cardiac rehabilitation programs to hsCRP values in patients with CHD who have undergone coronary artery bypass grafting (CABG).Methods :This study was conducted from April 2018 September 2018 with a total sample of 67 patients underwent phase II cardiac rehabilitation programs following CABG that met the inclusion and exclusion criteria. The hsCRP laboratory examination was conducted by the Clinical Pathology Laboratory of Haji Adam Malik General Hospital in two measurement periods, before and after the phase II cardiac rehabilitation program. And then the data was analyzed to see the relationship between cardiac rehabilitation and hsCRP value.Results: The total subjects of this study were 67 people that can be classified into two groups, high risk group (hsCRP >3 mg/dL)15 people (22.38%) and medium risk group (hsCRP 1-3 mg/dL)52 people (77.61%). Statistically significant improvements were found with p <0.05 in various parameters such as: body weight, body mass index (BMI), waist circumference, six minutes walk distance (6MWD), functional capacity, hsCRP value, total cholesterol, LDL, HDL, and TG. Negative correlation was obtained between hsCRP value and functional capacity before the program with r -0.689 and p <0.05. A negative correlation was found between hsCRP value and functional capacity after the program with r -0.819 and p <0.05.Conclusion : There was a relationship between cardiac rehabilitation and hsCRP in patients undergoingCABG. A significant decrease of hsCRP value was found in this study. Cardiac rehabilitation program not only improved laboratory components such as hsCRP and lipid profile, but also improved other metabolic parameters such as weight, BMI, waist circumference, and also improved the 6MWD and exercise capacity of patients after CABG. There was a statistically significant negative correlation between hsCRP values and functional capacity both before and after the rehabilitation program.
{"title":"Relationship between Cardiac Rehabilitation and High Sensitivity C-Reactive Protein in Patients undergoing Coronary Artery Bypass Graft Surgery","authors":"Nenny N. Sitohang, A. Siregar, A. N. Nasution, H. Hasan, Abdul Halim, F. Habib","doi":"10.20902/IJPTR.2019.120102","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120102","url":null,"abstract":"Background : Coronary heart disease (CHD), a gradual chronic inflammatory disease, is influenced by the environmental, lifestyle, and genetic factors that can be seen from traditional risk factors, inflammatory biomarkers, and metabolic status.Inflammatory biomarkers that were currently being studied include high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα), and intercellular adhesion molecule-1 (ICAM-1). Increased hsCRP is an independent risk factor that is important for CHD and determines the prognosis in patients who have CHD. Cardiac rehabilitation has a role in improving risk factors and preventing a variety of advanced cardiovascular events. This study aims to find the relationship of cardiac rehabilitation programs to hsCRP values in patients with CHD who have undergone coronary artery bypass grafting (CABG).Methods :This study was conducted from April 2018 September 2018 with a total sample of 67 patients underwent phase II cardiac rehabilitation programs following CABG that met the inclusion and exclusion criteria. The hsCRP laboratory examination was conducted by the Clinical Pathology Laboratory of Haji Adam Malik General Hospital in two measurement periods, before and after the phase II cardiac rehabilitation program. And then the data was analyzed to see the relationship between cardiac rehabilitation and hsCRP value.Results: The total subjects of this study were 67 people that can be classified into two groups, high risk group (hsCRP >3 mg/dL)15 people (22.38%) and medium risk group (hsCRP 1-3 mg/dL)52 people (77.61%). Statistically significant improvements were found with p <0.05 in various parameters such as: body weight, body mass index (BMI), waist circumference, six minutes walk distance (6MWD), functional capacity, hsCRP value, total cholesterol, LDL, HDL, and TG. Negative correlation was obtained between hsCRP value and functional capacity before the program with r -0.689 and p <0.05. A negative correlation was found between hsCRP value and functional capacity after the program with r -0.819 and p <0.05.Conclusion : There was a relationship between cardiac rehabilitation and hsCRP in patients undergoingCABG. A significant decrease of hsCRP value was found in this study. Cardiac rehabilitation program not only improved laboratory components such as hsCRP and lipid profile, but also improved other metabolic parameters such as weight, BMI, waist circumference, and also improved the 6MWD and exercise capacity of patients after CABG. There was a statistically significant negative correlation between hsCRP values and functional capacity both before and after the rehabilitation program.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74708254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120408
R. Budiarti
Background: Diabetes mellitus is still a problem in Indonesia, related to the number of organs involved. This disease has relatively high morbidity and mortality rates. Adjuvant therapy is needed considering the long-term therapy that must be consumed by patients. Objective: To explain the effect of hyperbaric oxygen in reducing blood glucose levels, and repairing histopathological damage to the pancreas and liver. Method : this study was an experimental laboratory study using whistar strain rats (Rattus Norvegicus) which were given a normal diet then induced alloxan to create a hyperglycemia condition. After that, 12 rats from the treatment group were given 3 x 30’ hyperbaric oxygen exposure for 6 days. Blood glucose levels, histopathological changes in the pancreas and liver was measured between the treatment group and the control group were not given hyperbaric oxygen exposure. Results: There was a significant difference (α< 0,05) in decreasing blood glucose and repairing histopathological damage in pancreatic and liver tissue between treated group and control group. Conclusion: hyperbaric oxygen treatment as much as 3 x 30'for days at 2.4 ATA O2 100% reduce blood glucose levels and repair histopathological damage to pancreatic tissue and liver of alloxan- induced white rats.
{"title":"Decreased Blood Glucose and Histopathology Improvement\u0000in Hyperbaric Hyperoxic Conditions Alloxan-induced\u0000rats(Laboratory Experimental Study)","authors":"R. Budiarti","doi":"10.20902/ijptr.2019.120408","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120408","url":null,"abstract":"Background: Diabetes mellitus is still a problem in Indonesia, related to the number of organs involved. This disease has relatively high morbidity and mortality rates. Adjuvant therapy is needed considering the long-term therapy that must be consumed by patients. Objective: To explain the effect of hyperbaric oxygen in reducing blood glucose levels, and repairing histopathological damage to the pancreas and liver. Method : this study was an experimental laboratory study using whistar strain rats (Rattus Norvegicus) which were given a normal diet then induced alloxan to create a hyperglycemia condition. After that, 12 rats from the treatment group were given 3 x 30’ hyperbaric oxygen exposure for 6 days. Blood glucose levels, histopathological changes in the pancreas and liver was measured between the treatment group and the control group were not given hyperbaric oxygen exposure. Results: There was a significant difference (α< 0,05) in decreasing blood glucose and repairing histopathological damage in pancreatic and liver tissue between treated group and control group. Conclusion: hyperbaric oxygen treatment as much as 3 x 30'for days at 2.4 ATA O2 100% reduce blood glucose levels and repair histopathological damage to pancreatic tissue and liver of alloxan- induced white rats.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90295977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120204
Yasmine F. Siregar, S. Kasiman, Z. Safri, H. Hasan, Abdul H. Reynaldo, F. Habib
Background: Non-ST segment elevation myocardial infarction (NSTEMI) has less frequent complications, but has worse long-term prognosis than ST segment elevation myocardial infarction (STEMI). Mortality rates of NSTEMI were lower than STEMI but after 6 months both mortality were similar. The purpose of this study was to determine the 2-year survival in patients with acute myocardial infarction (AMI). Method: This cohort retrospective study included 264 AMI patients treated from January – December 2015 in H. Adam Malik Medan General Hospital. The study sample was divided based on the diagnosis of STEMI and NSTEMI. Data were obtained from medical records. All patients were contacted by phone to determine their condition 2 years after experiencing AMI. Multivariate analysis was performed to assess the factors that affect the survival. The 2-year survival of STEMI and NSTEMI was compared using the Kaplan Meier plot.Result: From 264 patients, there were 216 (81.8%) men with median age of 56 years. We found 147 STEMI patients and 117 NSTEMI patients. NSTEMI group tended to have history of coronary artery disease, higher blood pressure, less revascularization, longer hospitalization days and less number of post AMI complications. Survival and mortality rates in 2 years were 58% and 28%. Multivariate analysis showed higher blood pressure (OR 1.023, CI 95%, 1.003 – 1.044) dan PCI during hospitalization (OR 8.604, CI 95%, 2.264 – 32.702) showed better 2-year survival. There were no significant 2-year survival differences between the two groups (log rank 0.136). Better 2-year survival was found in patients with single vessel disease (log rank 0.001), patients who received revascularization (log rank 0.001) and patients who did not experience heart failure or cardiogenic shock during hospitalization (log rank 0.001). Conclusion: There was no difference in 2-year survival between STEMI and NSTEMI patients who were admitted to H. Adam Malik Medan General Hospital in 2015. The 2-year survival appeared better in patients with single vessel disease, received revascularization and did not experience heart failure or cardiogenic shock during hospitalization. Keyword: survival, mortality, STEMI, NSTEMI. Yasmine F. Siregar et al /International Journal of PharmTech Research, 2019,12(2): 119127. DOI: http://dx.doi.org/10.20902/IJPTR.2019.120204 International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455-9563 Vol.12, No.02, pp 119-127, 2019 Yasmine F. Siregar et al /International Journal of PharmTech Research, 2019,12(2): 119-127. 120
背景:非ST段抬高型心肌梗死(NSTEMI)并发症发生率较低，但远期预后较ST段抬高型心肌梗死(STEMI)差。NSTEMI的死亡率低于STEMI，但6个月后两者的死亡率相似。本研究的目的是确定急性心肌梗死(AMI)患者的2年生存率。方法:对2015年1 - 12月在棉兰总医院就诊的264例AMI患者进行队列回顾性研究。根据STEMI和NSTEMI的诊断分为研究样本。数据来自医疗记录。通过电话联系所有患者，以确定AMI发生2年后的病情。通过多因素分析评估影响患者生存的因素。使用Kaplan Meier图比较STEMI和NSTEMI的2年生存率。结果:264例患者中，男性216例(81.8%)，中位年龄56岁。STEMI患者147例，NSTEMI患者117例。NSTEMI组有冠状动脉病史，血压较高，血运重建术较少，住院天数较长，AMI后并发症较少。2年生存率为58%，死亡率为28%。多因素分析显示，住院期间血压升高(OR 1.023, CI 95%， 1.003 ~ 1.044)和PCI (OR 8.604, CI 95%， 2.264 ~ 32.702)可提高2年生存率。两组2年生存率无显著差异(log rank 0.136)。单血管疾病患者(log rank 0.001)、接受血运重建术患者(log rank 0.001)和住院期间未发生心力衰竭或心源性休克的患者(log rank 0.001)的2年生存率更高。结论:2015年入住H. Adam Malik Medan总医院的STEMI和NSTEMI患者的2年生存率无差异。单血管疾病、接受血运重建术且住院期间未发生心力衰竭或心源性休克的患者的2年生存率更高。关键词:生存率，死亡率，STEMI, NSTEMI。张建军，张建军，张建军，等。中国生物医学工程学报，2016,32(2):1177 - 1177。DOI: http://dx.doi.org/10.20902/IJPTR.2019.120204 International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455-9563 Vol.12, No.02, pp 119-127, 2019 Yasmine F. Siregar等/International Journal of PharmTech Research, 2019,12(2): 119-127。120
{"title":"Two- Year Survival Analysis and Factors influencing Survival of Acute Myocardial Infarction","authors":"Yasmine F. Siregar, S. Kasiman, Z. Safri, H. Hasan, Abdul H. Reynaldo, F. Habib","doi":"10.20902/ijptr.2019.120204","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120204","url":null,"abstract":"Background: Non-ST segment elevation myocardial infarction (NSTEMI) has less frequent complications, but has worse long-term prognosis than ST segment elevation myocardial infarction (STEMI). Mortality rates of NSTEMI were lower than STEMI but after 6 months both mortality were similar. The purpose of this study was to determine the 2-year survival in patients with acute myocardial infarction (AMI). Method: This cohort retrospective study included 264 AMI patients treated from January – December 2015 in H. Adam Malik Medan General Hospital. The study sample was divided based on the diagnosis of STEMI and NSTEMI. Data were obtained from medical records. All patients were contacted by phone to determine their condition 2 years after experiencing AMI. Multivariate analysis was performed to assess the factors that affect the survival. The 2-year survival of STEMI and NSTEMI was compared using the Kaplan Meier plot.Result: From 264 patients, there were 216 (81.8%) men with median age of 56 years. We found 147 STEMI patients and 117 NSTEMI patients. NSTEMI group tended to have history of coronary artery disease, higher blood pressure, less revascularization, longer hospitalization days and less number of post AMI complications. Survival and mortality rates in 2 years were 58% and 28%. Multivariate analysis showed higher blood pressure (OR 1.023, CI 95%, 1.003 – 1.044) dan PCI during hospitalization (OR 8.604, CI 95%, 2.264 – 32.702) showed better 2-year survival. There were no significant 2-year survival differences between the two groups (log rank 0.136). Better 2-year survival was found in patients with single vessel disease (log rank 0.001), patients who received revascularization (log rank 0.001) and patients who did not experience heart failure or cardiogenic shock during hospitalization (log rank 0.001). Conclusion: There was no difference in 2-year survival between STEMI and NSTEMI patients who were admitted to H. Adam Malik Medan General Hospital in 2015. The 2-year survival appeared better in patients with single vessel disease, received revascularization and did not experience heart failure or cardiogenic shock during hospitalization. Keyword: survival, mortality, STEMI, NSTEMI. Yasmine F. Siregar et al /International Journal of PharmTech Research, 2019,12(2): 119127. DOI: http://dx.doi.org/10.20902/IJPTR.2019.120204 International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455-9563 Vol.12, No.02, pp 119-127, 2019 Yasmine F. Siregar et al /International Journal of PharmTech Research, 2019,12(2): 119-127. 120","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85280203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biocompatibility Assessments of Surgical sutures: Intracutaneous Reactivity Test in New Zealand White Rabbits","authors":"Tangthong Jiraporn, Klinkhamhom Aekkarin, Likitsuntornwong Wanlop, Amted Nanthana","doi":"10.20902/IJPTR.2019.120208","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120208","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86754712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120202
B. Khandare, P. Dudhe, S. Upasani, M. Dhoke
{"title":"Spectrophotometric Determination of Vandetanib in Bulk by Area Under Curve and First Order Derivative Methods","authors":"B. Khandare, P. Dudhe, S. Upasani, M. Dhoke","doi":"10.20902/ijptr.2019.120202","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120202","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79898424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120211
M. Jufri
{"title":"Preparation of Dry Dispersible Emulsion (DDE) to Enhance The Dissolution Rate of Curcumin","authors":"M. Jufri","doi":"10.20902/IJPTR.2019.120211","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120211","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82058347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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