Pub Date : 2020-01-01DOI: 10.20902/ijptr.2019.130304
Anju G Nagannawar, M. Jayaraj
Natural products from dietary components such as Indian species and medicinal plants are known to possess antioxidant activity. Antioxidants are inhibitors of oxidation are compounds which prevent the oxidation and in general prolong the life of the oxidizable matter. Majority of the diseases/disorders are mainly linked to oxidative stress due to free radicals. The free radicals (oxidants) are species with very short half-life, high reactivity and damaging activity towards macromolecules like proteins, DNA and lipids. In general, the reactive oxygen species circulating and react with the electron of other molecules in the body and these also affect various enzyme systems and cause damage which may further contribute to conditions such as cancer, ischemia, ageing, adult respiratory distress syndromes, rheumatoid arthritis etc. Dietary plants contain variable amounts of antioxidants. It has been proved that plant antioxidants may contribute to the beneficial health effects of dietary plants. The present study was to evaluate antioxidant activity of ethanolic extract of whole plant and leaf callus of Mollugo oppositifolia L. is an important traditional medicinal herb belonging to the family Molluginaceae using 2,2-diphenyl-1-Picryl-hydrazyl (DPPH) radical scavenging assays. The results obtained showed that the ethanolic extracts of whole plant and leaf callus showed significant DPPH activity with IC50 value of 52.82± 0.0017 μg/mL and 58.66±0.004 μg/mL respectively, while IC50 of vitamin C as standard was 84.84±11.54μg/mL. Present study revealed that an antioxidant activity was higher leaf callus extract compare to whole plant extract of Mollugo oppositifolia L..
{"title":"Comparative Antioxidant Activity of Ethanolic extracts of\u0000Whole Plant and Leaf Callus of Mollugo oppsitifolia L.\u0000A Potent Traditional Medicinal Herb","authors":"Anju G Nagannawar, M. Jayaraj","doi":"10.20902/ijptr.2019.130304","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130304","url":null,"abstract":"Natural products from dietary components such as Indian species and medicinal plants are known to possess antioxidant activity. Antioxidants are inhibitors of oxidation are compounds which prevent the oxidation and in general prolong the life of the oxidizable matter. Majority of the diseases/disorders are mainly linked to oxidative stress due to free radicals. The free radicals (oxidants) are species with very short half-life, high reactivity and damaging activity towards macromolecules like proteins, DNA and lipids. In general, the reactive oxygen species circulating and react with the electron of other molecules in the body and these also affect various enzyme systems and cause damage which may further contribute to conditions such as cancer, ischemia, ageing, adult respiratory distress syndromes, rheumatoid arthritis etc. Dietary plants contain variable amounts of antioxidants. It has been proved that plant antioxidants may contribute to the beneficial health effects of dietary plants. The present study was to evaluate antioxidant activity of ethanolic extract of whole plant and leaf callus of Mollugo oppositifolia L. is an important traditional medicinal herb belonging to the family Molluginaceae using 2,2-diphenyl-1-Picryl-hydrazyl (DPPH) radical scavenging assays. The results obtained showed that the ethanolic extracts of whole plant and leaf callus showed significant DPPH activity with IC50 value of 52.82± 0.0017 μg/mL and 58.66±0.004 μg/mL respectively, while IC50 of vitamin C as standard was 84.84±11.54μg/mL. Present study revealed that an antioxidant activity was higher leaf callus extract compare to whole plant extract of Mollugo oppositifolia L..","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"32 1","pages":"153-158"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78399668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20902/ijptr.2019.130318
Imrana Siddiqua, S. Maliha, M. M. A. Khan, T. Mamatha, Anupama Koneru
The heed on natural medications and their usage have been expanding quickly as of late, even in regions where present day medication is accessible. Plant derived substances and herbal drugs ,recently attracted great interest towards their unique & vast applications. As medicinal herbs, have bioactive compounds in abundance & can be utilized in conventional and current medication. There has been an increasing demand for plant based medicines, health products, pharmaceuticals, food supplements. The Objective of this Study is to enlighten the various immune enhancing properties of ginseng & to deliver these immune strengthening properties of ginseng it has been formulated into a syrup dosage form. Formulation of syrup was designed by utilizing extracts of Panax Ginseng, Sucrose, Benzoin & required quantity of Distilled water. The prepared herbal syrup was evaluated for different physicochemical parameters like pH, color, odour, taste, density, specific gravity, viscosity and stability. A review of Panax ginseng chemical constituents present in various parts of Panax ginseng is given in the present article. This may be useful in discovering potential therapeutic effects & developing new formulations.
{"title":"Preparation and Evaluation of Panax ginseng syrup","authors":"Imrana Siddiqua, S. Maliha, M. M. A. Khan, T. Mamatha, Anupama Koneru","doi":"10.20902/ijptr.2019.130318","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130318","url":null,"abstract":"The heed on natural medications and their usage have been expanding quickly as of late, even in regions where present day medication is accessible. Plant derived substances and herbal drugs ,recently attracted great interest towards their unique & vast applications. As medicinal herbs, have bioactive compounds in abundance & can be utilized in conventional and current medication. There has been an increasing demand for plant based medicines, health products, pharmaceuticals, food supplements. The Objective of this Study is to enlighten the various immune enhancing properties of ginseng & to deliver these immune strengthening properties of ginseng it has been formulated into a syrup dosage form. Formulation of syrup was designed by utilizing extracts of Panax Ginseng, Sucrose, Benzoin & required quantity of Distilled water. The prepared herbal syrup was evaluated for different physicochemical parameters like pH, color, odour, taste, density, specific gravity, viscosity and stability. A review of Panax ginseng chemical constituents present in various parts of Panax ginseng is given in the present article. This may be useful in discovering potential therapeutic effects & developing new formulations.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"40 1","pages":"272-276"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85107243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20902/ijptr.2019.130406
M. Sreenivasulu, K. Sivaiah, V. Naik
Background: An interaction is alleged to occur once the consequences of one drug is changed by the presence of another drug, herbal medicine, food, drink or by some environmental chemical agents. As per American psychological association drug interaction is defined as chemical or physiological reaction that can occur when two different drugs are taken together. Objective: This study was conducted for the detection of various drug interactions in dermatology in a tertiary care teaching hospital. Methods: An observational, prospective study was conducted for a period of six months (July 2017 to December 2017) among 108 patients in dermatology department of Santhiram Medical College and General Hospital, Nandyal. Results: A total of 108 patients were included in the study. Among them, 63 (58.3%) were males and 45(41.7%) were females. Of total 108 prescriptions, sever drug-drug interactions were present in 42 (38.9 %) prescriptions. Whereas, moderate drug-drug interactions were found in 14 (13%) and 52 prescriptions doesn’t have drug-drug interactions respectively. The study found the associations of potential drug interactions with age, sex, number of drugs per prescription. There was a direct link between polypharmacy and occurrence of drug interactions. To lower the frequency of potential interactions it could be necessary to make a careful selection of therapeutic alternatives, and in cases without other options, patients should be continuously monitored to identify adverse events. Conclusion: we concluded that educational interventions can minimize the incidence of drug interactions.
{"title":"A Study on Detection of Drug-Laboratory interactions in\u0000Dermatology, in a Tertiary Care Teaching Hospital","authors":"M. Sreenivasulu, K. Sivaiah, V. Naik","doi":"10.20902/ijptr.2019.130406","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130406","url":null,"abstract":"Background: An interaction is alleged to occur once the consequences of one drug is changed by the presence of another drug, herbal medicine, food, drink or by some environmental chemical agents. As per American psychological association drug interaction is defined as chemical or physiological reaction that can occur when two different drugs are taken together. Objective: This study was conducted for the detection of various drug interactions in dermatology in a tertiary care teaching hospital. Methods: An observational, prospective study was conducted for a period of six months (July 2017 to December 2017) among 108 patients in dermatology department of Santhiram Medical College and General Hospital, Nandyal. Results: A total of 108 patients were included in the study. Among them, 63 (58.3%) were males and 45(41.7%) were females. Of total 108 prescriptions, sever drug-drug interactions were present in 42 (38.9 %) prescriptions. Whereas, moderate drug-drug interactions were found in 14 (13%) and 52 prescriptions doesn’t have drug-drug interactions respectively. The study found the associations of potential drug interactions with age, sex, number of drugs per prescription. There was a direct link between polypharmacy and occurrence of drug interactions. To lower the frequency of potential interactions it could be necessary to make a careful selection of therapeutic alternatives, and in cases without other options, patients should be continuously monitored to identify adverse events. Conclusion: we concluded that educational interventions can minimize the incidence of drug interactions.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"160 38 1","pages":"350-355"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89059434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20902/ijptr.2019.130214
B. Nagaraju, A. Ramu, S. Vidhyadhara
Nature is the best source of complementary and alternative medicine. The plant Biophytum reinwardtii has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, fraction of methanolic extract of Biophytum reinwardtii was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetyl cholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer’s disease (AD). The purpose of this study was to investigate the neuroprotective effect of HEMBR on learning and memory impairment in scopolamine-induced rats of dementia and oxidative stress. Treatment with HEMBR (i.e., 50 and 100 mg/kg b.w.) was investigated in scopolamine-treated Swiss albino male rats for 7 days and its neuroprotective effects were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test and, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), reduced glutathione (GSH) and acetylcholinesterase (AChE) activity in rat brain tissue homogenates. The present study demonstrates that HEMBR showed the neuroprotective effect by improving cognitive functions and reduces oxidative stress by increasing the level of brain antioxidant enzymes as well as decreasing acetylcholinesterase activity. Therefore, this plant extract faction can be used for enhancing learning, memory, antioxidant potentiality and anti-acetylcholinesterase activity in neurodegenerative disorders like AD.
{"title":"Evaluation of Neuroprotective and In-vitro Anti-oxidant\u0000Activity Isolated Hexane and Ethyl Acetate Fraction from\u0000Methanolic Extract of Biophytum reinwardtii","authors":"B. Nagaraju, A. Ramu, S. Vidhyadhara","doi":"10.20902/ijptr.2019.130214","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130214","url":null,"abstract":"Nature is the best source of complementary and alternative medicine. The plant Biophytum reinwardtii has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, fraction of methanolic extract of Biophytum reinwardtii was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetyl cholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer’s disease (AD). The purpose of this study was to investigate the neuroprotective effect of HEMBR on learning and memory impairment in scopolamine-induced rats of dementia and oxidative stress. Treatment with HEMBR (i.e., 50 and 100 mg/kg b.w.) was investigated in scopolamine-treated Swiss albino male rats for 7 days and its neuroprotective effects were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test and, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), reduced glutathione (GSH) and acetylcholinesterase (AChE) activity in rat brain tissue homogenates. The present study demonstrates that HEMBR showed the neuroprotective effect by improving cognitive functions and reduces oxidative stress by increasing the level of brain antioxidant enzymes as well as decreasing acetylcholinesterase activity. Therefore, this plant extract faction can be used for enhancing learning, memory, antioxidant potentiality and anti-acetylcholinesterase activity in neurodegenerative disorders like AD.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"1 1","pages":"110-122"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82991306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120207
A. Rani, A. Uppala
Serratiopeptidase is an anti inflammatory enzyme commonly used in the treatment of various inflammatory disorders. It is found to have no GI related side effects unlike NSAIDs and can be safely used for chronic conditions. Formulations of controlled release tablets can decrease the frequency of administration and thereby improve the patient compliance. As Serratiopeptidase is acid-liable, it is made into enteric dispersion with the polymer viz. Eudragit L 100 by solvent evaporation technique. The polymer is used in various proportions and the optimum solid dispersion was selected based on the drug release study for enteric products. The controlled release tablets of the Serratiopeptidase solid dispersion were prepared with the polymers viz. ethyl cellulose, hydroxypropylmethylcellulose and methylcellulose in various proportions. Drug release study was conducted for 6 hours in pH 6.8 phosphate buffer. The formulation containing ethyl cellulose in 125 mg quantity showed drug release in controlled manner upto 6 hours.
{"title":"Enteric dispersion or Serratiopeptidase with Eudragit L100 and Formulation of Controlled Release Tablets of Serratiopeptidase","authors":"A. Rani, A. Uppala","doi":"10.20902/ijptr.2019.120207","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120207","url":null,"abstract":"Serratiopeptidase is an anti inflammatory enzyme commonly used in the treatment of various inflammatory disorders. It is found to have no GI related side effects unlike NSAIDs and can be safely used for chronic conditions. Formulations of controlled release tablets can decrease the frequency of administration and thereby improve the patient compliance. As Serratiopeptidase is acid-liable, it is made into enteric dispersion with the polymer viz. Eudragit L 100 by solvent evaporation technique. The polymer is used in various proportions and the optimum solid dispersion was selected based on the drug release study for enteric products. The controlled release tablets of the Serratiopeptidase solid dispersion were prepared with the polymers viz. ethyl cellulose, hydroxypropylmethylcellulose and methylcellulose in various proportions. Drug release study was conducted for 6 hours in pH 6.8 phosphate buffer. The formulation containing ethyl cellulose in 125 mg quantity showed drug release in controlled manner upto 6 hours.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73038206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120201
Virsa Handayani, A. Najib, Rezki Amriati Syarif, A. Mahmud, N. Asha, Aktsar Roskiana Ahmad
{"title":"Standardization of Purified Extract Mahoni Seed and Antioxidant Activity","authors":"Virsa Handayani, A. Najib, Rezki Amriati Syarif, A. Mahmud, N. Asha, Aktsar Roskiana Ahmad","doi":"10.20902/IJPTR.2019.120201","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120201","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83987509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120305
Dhruti Avlani, Dipanjana Ash, S. Majee, G. Biswas
: Intranasal gel formulation with mucilage of natural origin has been potentially explored as an alternative dosage form of drug administration. The purpose of present investigation was to develop paracetamol loaded nasal gel with sweet basil seed mucilage (BSM) as a gelling agent obtained by thermal-hydration process and to characterise both mucilage as well as the gel formulations. Phytochemical screening of BSM reveals it to be rich in carbohydrates. The FT-IR spectrum of the mucilage exhibits the presence of O–H, C–H, and –COO − . The mucilage showed high swelling index of 462% and relative viscosity of BSM dispersion (0.25% w/v) in nasal medium was found to be 2.94 at 25 ⁰ C. Nasal gel formulations demonstrated satisfactory pH, spreadability, extrudibility and drug content. The in vitro release profile of G1 (6%w/w BSM) demonstrated almost 95% release with Korsmeyer-Peppas kinetics with highest values of permeability coefficient and steady-state flux. Other formulations with 8-10%w/w BSM exhibited 70-80% release within 2.5 hours. G2 and G3 followed zero order kinetics with quasi-Fickian diffusion. The study indicates that G1 (6 %w/w BSM) can be selected for nasal gel formulation which may be used for in vivo studies in future. microvilli, high vascularization of the subepithelial layer, porous endothelial membrane with a capacity of avoiding hepatic first pass metabolism and thus presents a potentially useful site for the delivery of proteins and peptides. 1,2 Intranasal administration is non-invasive, painless, does not require a sterile preparation, and the drug can be easily and readily administered in relatively low doses thereby minimizing the systemic toxic effects of oral and parenteral routes. Examples
{"title":"Sweet Basil Seed Mucilage as a Gelling agent in Nasal Drug Delivery","authors":"Dhruti Avlani, Dipanjana Ash, S. Majee, G. Biswas","doi":"10.20902/IJPTR.2019.120305","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120305","url":null,"abstract":": Intranasal gel formulation with mucilage of natural origin has been potentially explored as an alternative dosage form of drug administration. The purpose of present investigation was to develop paracetamol loaded nasal gel with sweet basil seed mucilage (BSM) as a gelling agent obtained by thermal-hydration process and to characterise both mucilage as well as the gel formulations. Phytochemical screening of BSM reveals it to be rich in carbohydrates. The FT-IR spectrum of the mucilage exhibits the presence of O–H, C–H, and –COO − . The mucilage showed high swelling index of 462% and relative viscosity of BSM dispersion (0.25% w/v) in nasal medium was found to be 2.94 at 25 ⁰ C. Nasal gel formulations demonstrated satisfactory pH, spreadability, extrudibility and drug content. The in vitro release profile of G1 (6%w/w BSM) demonstrated almost 95% release with Korsmeyer-Peppas kinetics with highest values of permeability coefficient and steady-state flux. Other formulations with 8-10%w/w BSM exhibited 70-80% release within 2.5 hours. G2 and G3 followed zero order kinetics with quasi-Fickian diffusion. The study indicates that G1 (6 %w/w BSM) can be selected for nasal gel formulation which may be used for in vivo studies in future. microvilli, high vascularization of the subepithelial layer, porous endothelial membrane with a capacity of avoiding hepatic first pass metabolism and thus presents a potentially useful site for the delivery of proteins and peptides. 1,2 Intranasal administration is non-invasive, painless, does not require a sterile preparation, and the drug can be easily and readily administered in relatively low doses thereby minimizing the systemic toxic effects of oral and parenteral routes. Examples","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84245968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/ijptr.2019.120405
S. Gejalakshmi, N. Harikrishnan
Drug discovery leading to robust and viable lead candidate’s remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. The present research attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as ―natural product drug discovery
{"title":"Molecular Docking Study of Quercetein Analogues for\u0000Treating Tumours","authors":"S. Gejalakshmi, N. Harikrishnan","doi":"10.20902/ijptr.2019.120405","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120405","url":null,"abstract":"Drug discovery leading to robust and viable lead candidate’s remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. The present research attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as ―natural product drug discovery","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78882117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120303
R. Pujari, D. Bandawane
Hematological toxicity is a frequent and severe adverse effect of carboplatin chemotherapy, limiting its clinical use despite being one of the most potent anticancer agents. The present study was designed to evaluate the protective effects of a naturally occurring plant phenolic acids i.e. gentisic acid (2,5 dihyroxybenzoic acid) against carboplatin induced hematological toxicities in wistar rats. Exposure to carboplatin at a dose of 35 mg/kg caused significant decrease in hematological parameters of blood such as red blood cells, total leucocytes, platelets, neutrophills, basophills, lymphocytes and moncytes counts whereas increase in eosiphill counts rat blood indicating severe pancytopenia. Administration of gentisic acid at 10, 30 and 100 for 14 days resulted in a significant amelioration of altered blood parameters in a dose dependent manner indicating its potential as a protective agent for the prevention and amelioration of caboplatin induced hematological toxicities.
{"title":"Ameliorative effects of Gentisic acid on carboplatin induced hematological toxicities in Wistar Rats","authors":"R. Pujari, D. Bandawane","doi":"10.20902/IJPTR.2019.120303","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120303","url":null,"abstract":"Hematological toxicity is a frequent and severe adverse effect of carboplatin chemotherapy, limiting its clinical use despite being one of the most potent anticancer agents. The present study was designed to evaluate the protective effects of a naturally occurring plant phenolic acids i.e. gentisic acid (2,5 dihyroxybenzoic acid) against carboplatin induced hematological toxicities in wistar rats. Exposure to carboplatin at a dose of 35 mg/kg caused significant decrease in hematological parameters of blood such as red blood cells, total leucocytes, platelets, neutrophills, basophills, lymphocytes and moncytes counts whereas increase in eosiphill counts rat blood indicating severe pancytopenia. Administration of gentisic acid at 10, 30 and 100 for 14 days resulted in a significant amelioration of altered blood parameters in a dose dependent manner indicating its potential as a protective agent for the prevention and amelioration of caboplatin induced hematological toxicities.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90944627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.20902/IJPTR.2019.120106
R. Maharani, Kusmardi, B. Elya
Colitis Ulcerative is a major public health problem throught the worldwide. Recently many studies have focused to finding antinflammatory based on the natural product. The study was aimed to investigative the inhibitory activity of Phaleria macrocarpa leaves extract on goblet cell in colitis ulcerative. Methods: In this study, Swiss mice were induced by 2% dextran sodium sulfate during a week. Phaleria macrocarpa leaves extract each dose of 100, 200, and 300 mg daily and aspirin 0.2 mg, administered orally. Histopathological examination of the colon tissue (hematoxylin-eosin staining) was done by counting the number of goblet cells a in five randomly selected fields visual. The results: Phaleria macrocarpa leaves extract significantly inhibit the depletion of the count of goblet cells (P 0.000) in colitis. Phaleria macrocarpa leaves extract significantly reduce the amount of focus of inflammation (P 0.000) in colitis. Conclusion: Our results indicated that may have inhibitory activity in colitis through inhibiting reduction in the number of goblet cell.
{"title":"Inhibitory Activity Goblet Depletion and focal inflammatory Phaleria macrocarpha Leaves Ethanol Extract on Crypta Mouse after Dextran Sodium Sulphate Induction","authors":"R. Maharani, Kusmardi, B. Elya","doi":"10.20902/IJPTR.2019.120106","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120106","url":null,"abstract":"Colitis Ulcerative is a major public health problem throught the worldwide. Recently many studies have focused to finding antinflammatory based on the natural product. The study was aimed to investigative the inhibitory activity of Phaleria macrocarpa leaves extract on goblet cell in colitis ulcerative. Methods: In this study, Swiss mice were induced by 2% dextran sodium sulfate during a week. Phaleria macrocarpa leaves extract each dose of 100, 200, and 300 mg daily and aspirin 0.2 mg, administered orally. Histopathological examination of the colon tissue (hematoxylin-eosin staining) was done by counting the number of goblet cells a in five randomly selected fields visual. The results: Phaleria macrocarpa leaves extract significantly inhibit the depletion of the count of goblet cells (P 0.000) in colitis. Phaleria macrocarpa leaves extract significantly reduce the amount of focus of inflammation (P 0.000) in colitis. Conclusion: Our results indicated that may have inhibitory activity in colitis through inhibiting reduction in the number of goblet cell.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85477910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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