Sukeshini B. Lote, S. Agrawal, Shirin Ghune, Pravina Gurjar
A high-performance thin layer chromatography (HPTLC) method for the quantification of quercetin was developed on methanolic extract of dill (Anethum graveolens) seeds and subsequently validated. A suitable mobile phase was used to establish the HPTLC method, ethyl acetate, toluene, methanol, chloroform, and formic acid (2:3:3:2). A densitometric analysis was done at 366 nm of wavelength. Quercetin has an Rf value of 0.55. In the dilution range of 100 to 800 ng per band, quercetin revealed a linear connection with r2= 0.9938 in the calibration’s linear regression analysis. By conducting replication analysis on 2 separate days and one day, accuracy was verified. The standard addition method was used to conduct recovery studies to validate accuracy. The quercetin recovery rate was 98.60% on average. Five replicates of each of the three standards were used to detect the system suitability parameter. With regard to both the peak area and the Rf value, the %RSD was observed to be under 2%. The mobile phase concentration was altered from Toluene: Ethyl acetate: Chloroform: Methanol (2:3:3:2) to (3:2:2:3) with few drops of formic acid. It was found to have a %RSD of peak area below 10%, the robustness of the method was assessed. The developed HPTLC method was discovered to be easy to use, precise, accurate, suitable, and robust for estimating quercetin from dill seed extract.
{"title":"Validated HPTLC Analysis for Estimation of Quercetin in Seeds of Anethum graveolens","authors":"Sukeshini B. Lote, S. Agrawal, Shirin Ghune, Pravina Gurjar","doi":"10.25258/ijpqa.14.2.05","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.05","url":null,"abstract":"A high-performance thin layer chromatography (HPTLC) method for the quantification of quercetin was developed on methanolic extract of dill (Anethum graveolens) seeds and subsequently validated. A suitable mobile phase was used to establish the HPTLC method, ethyl acetate, toluene, methanol, chloroform, and formic acid (2:3:3:2). A densitometric analysis was done at 366 nm of wavelength. Quercetin has an Rf value of 0.55. In the dilution range of 100 to 800 ng per band, quercetin revealed a linear connection with r2= 0.9938 in the calibration’s linear regression analysis. By conducting replication analysis on 2 separate days and one day, accuracy was verified. The standard addition method was used to conduct recovery studies to validate accuracy. The quercetin recovery rate was 98.60% on average. Five replicates of each of the three standards were used to detect the system suitability parameter. With regard to both the peak area and the Rf value, the %RSD was observed to be under 2%. The mobile phase concentration was altered from Toluene: Ethyl acetate: Chloroform: Methanol (2:3:3:2) to (3:2:2:3) with few drops of formic acid. It was found to have a %RSD of peak area below 10%, the robustness of the method was assessed. The developed HPTLC method was discovered to be easy to use, precise, accurate, suitable, and robust for estimating quercetin from dill seed extract.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48651880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayuri N. Deshmukh, Vaibhav Uplanchiwar, V. M. Thakare, Namrata S. Mane, S. Gaikwad, N. Dighade, Hina. Mehta, R. Bakal, Prashant R. Umate
This paper describes a new, simple, accurate and economical method of development and validation of HPLC method for the assessment of dicyclomine hydrochloride with omeprazol magnesium combine dosage form. The method development trial was carried out initially using C8 (100×0.46×3.5 μm) and C18 GraceSmart (250×4.6×5 μm) as stationary phase and acetate buffer (pH 4.5) and methanol as mobile phase in proportion 60:40v/v. The optimized conditions of factors were sample size 50 μL and wavelength (λmax) 215 nm. The developed method was then applied to in-vitro dissolution studies for the dicyclomine hydrochloride and omeprazole magnesium. As per ICH guidelines, stability testing was done. The estimated method can be used to analyze the pharma industries’ products.
{"title":"Development and Validation of HPLC Method for Estimation of Some Active Analytes in Combined Dosage form an Application to In-vitro Dissolution Studies","authors":"Mayuri N. Deshmukh, Vaibhav Uplanchiwar, V. M. Thakare, Namrata S. Mane, S. Gaikwad, N. Dighade, Hina. Mehta, R. Bakal, Prashant R. Umate","doi":"10.25258/ijpqa.14.2.16","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.16","url":null,"abstract":"This paper describes a new, simple, accurate and economical method of development and validation of HPLC method for the assessment of dicyclomine hydrochloride with omeprazol magnesium combine dosage form. The method development trial was carried out initially using C8 (100×0.46×3.5 μm) and C18 GraceSmart (250×4.6×5 μm) as stationary phase and acetate buffer (pH 4.5) and methanol as mobile phase in proportion 60:40v/v. The optimized conditions of factors were sample size 50 μL and wavelength (λmax) 215 nm. The developed method was then applied to in-vitro dissolution studies for the dicyclomine hydrochloride and omeprazole magnesium. As per ICH guidelines, stability testing was done. The estimated method can be used to analyze the pharma industries’ products.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45968588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A cross-sectional study was conducted among full-time health professionals of both genders who agreed to participate and sign the consent form. A self-administered, standardized, work-related stress (WSQ) and perceived stress (PSS-10) questionnaire were used. In addition, information on socio-demography, general health, and work characteristics was obtained. Data was analyzed by SPSS version 27. The Chi-square test and logistic analysis were used. Results: The prevalence of moderate/high stress was 90%. The greatest prevalence of high stress was found among older compared to younger professionals [8.6 vs.7.5%, p=0.004], females compared to males [8.1 vs.7.8%, p=0.006], specialist/consultant compared to nurses and medical practitioners [9.7, 8, 2.6%; p=0.01]. Working > 48 hours/ week compared to ≤ 48 hours/week [8.6 vs. 6.3%, p=0.005], have chronic disease compared to No chronic disease [ 8.2 vs. 7.8%, p=0.04]. The percentage of stress in the following work domains: low influence at work; work interference with leisure time; items in “Indistinct Organization and Conflicts” and “Demands and commitments” were: 13, 70.3, 12.1 and 16.3%, respectively. Logistic analyses showed that gender and age significantly predict a high-stress level. Conclusion: The present study showed a high prevalence (90%) of moderate- to high-stress levels. Age and gender were significant predictors of high-stress levels among healthcare professionals. The most frequent work-related stress factor was work interference with leisure time (70.3%).
{"title":"Prevalence of Stress Among Health Professionals During COVID-19 Pandemic in The UAE: A Cross-sectional Study","authors":"S. L. Budihal, S. A. Sharbatti","doi":"10.25258/ijpqa.14.2.13","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.13","url":null,"abstract":"A cross-sectional study was conducted among full-time health professionals of both genders who agreed to participate and sign the consent form. A self-administered, standardized, work-related stress (WSQ) and perceived stress (PSS-10) questionnaire were used. In addition, information on socio-demography, general health, and work characteristics was obtained. Data was analyzed by SPSS version 27. The Chi-square test and logistic analysis were used. Results: The prevalence of moderate/high stress was 90%. The greatest prevalence of high stress was found among older compared to younger professionals [8.6 vs.7.5%, p=0.004], females compared to males [8.1 vs.7.8%, p=0.006], specialist/consultant compared to nurses and medical practitioners [9.7, 8, 2.6%; p=0.01]. Working > 48 hours/ week compared to ≤ 48 hours/week [8.6 vs. 6.3%, p=0.005], have chronic disease compared to No chronic disease [ 8.2 vs. 7.8%, p=0.04]. The percentage of stress in the following work domains: low influence at work; work interference with leisure time; items in “Indistinct Organization and Conflicts” and “Demands and commitments” were: 13, 70.3, 12.1 and 16.3%, respectively. Logistic analyses showed that gender and age significantly predict a high-stress level. Conclusion: The present study showed a high prevalence (90%) of moderate- to high-stress levels. Age and gender were significant predictors of high-stress levels among healthcare professionals. The most frequent work-related stress factor was work interference with leisure time (70.3%).","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46980043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
For centuries, herbal remedies have been used to prevent and treat disease. Horse chestnut seeds are an abundant source of phytoconstituents containing triterpenoid saponins, with thirty molecules isolated and characterized. Escin, which is a combination of acylated triterpene glycosides composed of α- and β-escin, is the major biologically active component of horse chestnut seed extract. Escin is the most researched veno-active compound with anti-inflammatory, anti-oedematous, and antioxidant properties. Due to their unique three pharmacological actions, escin is a well-established molecule for the management of venous diseases such as chronic venous insufficiency (CVI) and hemorrhoids. The available treatments for CVI have some disadvantages, including severe side effects, expensive surgical options, long duration of treatment, and limited accessibility to allopathic drugs. As a result, phytoconstituents and lifestyle changes can be seen as safe and effective therapy options for CVI management because they have no major side effects and can simultaneously function on several targets. This review article focuses on the chemical components of horse chestnut extract, particularly the phytoconstituents escin, and proanthocyanidins, which have been extensively studied in preclinical and clinical studies. The review article provides a comprehensive overview of their potential therapeutic benefits in managing symptoms of CVI and their regulatory status.
{"title":"Horse Chestnut Seed Extract: An Opportunity for Creating Evidencebased New Natural Products","authors":"Poonam N. Chougule, M. Tayade, N. Chougule","doi":"10.25258/ijpqa.14.2.33","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.33","url":null,"abstract":"For centuries, herbal remedies have been used to prevent and treat disease. Horse chestnut seeds are an abundant source of phytoconstituents containing triterpenoid saponins, with thirty molecules isolated and characterized. Escin, which is a combination of acylated triterpene glycosides composed of α- and β-escin, is the major biologically active component of horse chestnut seed extract. Escin is the most researched veno-active compound with anti-inflammatory, anti-oedematous, and antioxidant properties. Due to their unique three pharmacological actions, escin is a well-established molecule for the management of venous diseases such as chronic venous insufficiency (CVI) and hemorrhoids. The available treatments for CVI have some disadvantages, including severe side effects, expensive surgical options, long duration of treatment, and limited accessibility to allopathic drugs. As a result, phytoconstituents and lifestyle changes can be seen as safe and effective therapy options for CVI management because they have no major side effects and can simultaneously function on several targets. This review article focuses on the chemical components of horse chestnut extract, particularly the phytoconstituents escin, and proanthocyanidins, which have been extensively studied in preclinical and clinical studies. The review article provides a comprehensive overview of their potential therapeutic benefits in managing symptoms of CVI and their regulatory status.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42268582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Smita Mujbaile, D. Khobragade, Dharmenndra Mundhada
The leaf extracts of plant Lantana camara shows significant antithrombin and thrombolytic activity. Modified release form of extract will show better therapeutics efficiency. In this work the extracts of plant L. camara-loaded polycaprolactone microspheres were prepared using the double emulsion method. 32 design approaches were used for the optimization of polycaprolactone and PVP concentration for response entrapment efficiency (Y1) and drug release (Y2). The microspheres of L. camara were analyzed for EE, FTIR, DSC, XRD and drug release. The entrapment efficiency of L. camara microspheres was in ranges of 62.25 to 84.04%. The particle size of optimized batch of microspheres was 789.6 (d. nm) with PDI 0.838. It shows pH dependant swelling with no interaction between drug and polymer was observed in DSC studies. The % drug release of all thirteen batches was in ranges of 87.91 to 99.04% for 12 hours duration. From the study we conclude the prepared L. camara loaded polycaprolactone microspheres show sustained release action for 12 hours.
植物山楂叶提取物具有显著的抗凝血酶和溶栓活性。改良的提取物释放形式将显示出更好的治疗效果。本研究采用双乳法制备了植物L. camara-聚己内酯提取物微球。采用32种设计方法对聚己内酯和PVP浓度的响应包封效率(Y1)和药物释放率(Y2)进行优化。采用EE、FTIR、DSC、XRD和药物释放分析等方法对其微球进行分析。柠条微球的捕集率为62.25% ~ 84.04%。优化后的微球粒径为789.6 (d. nm)， PDI为0.838。DSC研究显示，pH依赖性肿胀与药物和聚合物之间没有相互作用。13批药物在12小时内的释放率在87.91 ~ 99.04%之间。实验结果表明，制备的蓖麻载聚己内酯微球具有12小时的缓释作用。
{"title":"Formulation and Optimisation of Microspheres of Leaves extract of Lantana camara 32 Design Approach","authors":"Smita Mujbaile, D. Khobragade, Dharmenndra Mundhada","doi":"10.25258/ijpqa.14.2.04","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.04","url":null,"abstract":"The leaf extracts of plant Lantana camara shows significant antithrombin and thrombolytic activity. Modified release form of extract will show better therapeutics efficiency. In this work the extracts of plant L. camara-loaded polycaprolactone microspheres were prepared using the double emulsion method. 32 design approaches were used for the optimization of polycaprolactone and PVP concentration for response entrapment efficiency (Y1) and drug release (Y2). The microspheres of L. camara were analyzed for EE, FTIR, DSC, XRD and drug release. The entrapment efficiency of L. camara microspheres was in ranges of 62.25 to 84.04%. The particle size of optimized batch of microspheres was 789.6 (d. nm) with PDI 0.838. It shows pH dependant swelling with no interaction between drug and polymer was observed in DSC studies. The % drug release of all thirteen batches was in ranges of 87.91 to 99.04% for 12 hours duration. From the study we conclude the prepared L. camara loaded polycaprolactone microspheres show sustained release action for 12 hours.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48115456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jitendra Kandale, J. Sangshetti, P. Mahaparale, G. Dama, J. Bidkar
Ocimum sanctum, Rubia cordifolia, Glycyrrhiza glabra, and Punica granatum are all used to treat various diseases and conditions in Ayurvedic medicine. In this study, we aimed to formulate and evaluate a polyherbal emulgel containing extracts from four different medicinal plants: O. sanctum, R. cordifolia, G. glabra, and P. granatum. Different gel formulations were created by combining a base component with extracts from O. sanctum, R. cordifolia, G. glabra, and P. granatum. pH, viscosity, rheology, appearance, and homogeneity were some of the criteria examined for each formulation. They were tested for evaporation and irritation of the epidermis with patches. The cup plate method was used to examine the antibacterial-antifungal activity of formulations against Escherichia coli, Pseudomonas aeruginosa, and Aspergillus niger. Results showed that the inhibition zones produced by all formulations were greater than those produced by the control. Antimicrobial characteristics can be found in polyherbal gels. Synergy between the plant components in the blend produced the desirable outcome.
在阿育吠陀医学中，茴香、芦花、甘草和石榴都被用来治疗各种疾病和病症。在这项研究中，我们的目的是制备和评价一种含有四种不同药用植物提取物的多草药乳液:O. sanctum, R. cordifolia, G. glabra和P. granatum。不同的凝胶配方是通过将一种基础成分与圣草、堇青花、光天化日和石榴的提取物结合而成的。pH值，粘度，流变性，外观和均匀性是每个配方检查的一些标准。他们被测试蒸发和刺激表皮斑块。采用杯盘法检测制剂对大肠杆菌、铜绿假单胞菌和黑曲霉的抑菌抑菌活性。结果表明，各剂型的抑菌带均大于对照。抗菌特性可以在多草药凝胶中找到。混合物中植物组分之间的协同作用产生了期望的结果。
{"title":"Phytochemical Evaluation of Extracts and Pharmacological Activity of Polyherbal Emulgel","authors":"Jitendra Kandale, J. Sangshetti, P. Mahaparale, G. Dama, J. Bidkar","doi":"10.25258/ijpqa.14.2.17","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.17","url":null,"abstract":"Ocimum sanctum, Rubia cordifolia, Glycyrrhiza glabra, and Punica granatum are all used to treat various diseases and conditions in Ayurvedic medicine. In this study, we aimed to formulate and evaluate a polyherbal emulgel containing extracts from four different medicinal plants: O. sanctum, R. cordifolia, G. glabra, and P. granatum. Different gel formulations were created by combining a base component with extracts from O. sanctum, R. cordifolia, G. glabra, and P. granatum. pH, viscosity, rheology, appearance, and homogeneity were some of the criteria examined for each formulation. They were tested for evaporation and irritation of the epidermis with patches. The cup plate method was used to examine the antibacterial-antifungal activity of formulations against Escherichia coli, Pseudomonas aeruginosa, and Aspergillus niger. Results showed that the inhibition zones produced by all formulations were greater than those produced by the control. Antimicrobial characteristics can be found in polyherbal gels. Synergy between the plant components in the blend produced the desirable outcome.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48399693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Rajauria, Sarita Jangra, Lokesh Barde, Kranti P. Musmade, Shaima Ka, B. Bhyan, C. Vani, V. S., R. S, H. Tare
Introduction: Hair is a versatile structure, and its importance has been linked to it in the beautification of human beings for ages. According to studies on the psychological impacts of androgenetic alopecia (AGA) in men, they are older, weaker, and less appealing. Hair loss in women gives significant stress and lowers self-confidence. Aim: To perform videodermoscopic findings in non-scarring alopecia of scalp versus control volunteers. Material and Methods: Total of 140 patients satisfied the study’s inclusion criteria after a general medical examination, scalp examination (including inspection of the hair shaft and root), and hair anchoring and fragility tests. We examined the lesions with a videodermoscopy, took images, and wrote up our findings. Results: The study found that patients averaged 26.85. Onset averaged 25.15 alopecia averaged 10.3 months. Our sample had 87.7% spotty AA. Conclusion: Videodermoscopy is an effective non-invasive tool of considerable potential in dermatological practice. It is becoming popular as a hair loss differential diagnosis tool.
{"title":"Videodermoscopy Evaluation in Non-scarring Alopecia of Scalp","authors":"G. Rajauria, Sarita Jangra, Lokesh Barde, Kranti P. Musmade, Shaima Ka, B. Bhyan, C. Vani, V. S., R. S, H. Tare","doi":"10.25258/ijpqa.14.2.26","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.26","url":null,"abstract":"Introduction: Hair is a versatile structure, and its importance has been linked to it in the beautification of human beings for ages. According to studies on the psychological impacts of androgenetic alopecia (AGA) in men, they are older, weaker, and less appealing. Hair loss in women gives significant stress and lowers self-confidence. Aim: To perform videodermoscopic findings in non-scarring alopecia of scalp versus control volunteers. Material and Methods: Total of 140 patients satisfied the study’s inclusion criteria after a general medical examination, scalp examination (including inspection of the hair shaft and root), and hair anchoring and fragility tests. We examined the lesions with a videodermoscopy, took images, and wrote up our findings. Results: The study found that patients averaged 26.85. Onset averaged 25.15 alopecia averaged 10.3 months. Our sample had 87.7% spotty AA. Conclusion: Videodermoscopy is an effective non-invasive tool of considerable potential in dermatological practice. It is becoming popular as a hair loss differential diagnosis tool.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49495987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Alkaim, F. H. Abdulrazzak, Shaimaa M. Essa, Usama S. Altimari, Montather F. Ramadan, Aseel M. Aljeboree
In this research, preparation of methacrylic acid-acrylamide based ZnO hydrogel nanocomposite (MAA-AM)/ZnO hydrogel nanocomposite by way of co-polymerization via used acrylate acid (AA) (or acrylate salt) (AA) or methacrylic acid (MAA)) and acrylamide (AM). Nanocomposites based on acrylate are characterized via being hydrophilic and able to retain water. Nanocomposite properties were studied using different techniques (FE-SEM, TEM, and EDX). The photocatalytic degradation of methylene blue MB dye under different conditions was studied using nanocomposite like time of irradiation, mass of catalyst (MAA- AM)/ZnO hydrogel nanocomposite, initial MB dye concentration onto photocatalytic degradation and reactivation were studied. The result increases the photocatalytic degradation with the rise weight of catalyst (MAA- AM)/ZnO hydrogel nanocomposite range (0.1–0.25 g). Too, a decrease in photocatalytic degradation was observed with an increase in MB. Observed that after reuse, ((MAA- AM)/ZnO) nanocomposite hydrogel appear photocatalytic efficiency from of the use 1 to 6 cycle 87.88 to 58.87%, showing that ((MAA- AM)/ZnO hydrogel nanocomposite surface appear good stability.
{"title":"Methacrylic Acid-Acrylamide based ZnO Hydrogel Nanocomposite Assisted Photocatalytic Decolorization of Methylene Blue Dye","authors":"A. Alkaim, F. H. Abdulrazzak, Shaimaa M. Essa, Usama S. Altimari, Montather F. Ramadan, Aseel M. Aljeboree","doi":"10.25258/ijpqa.14.2.06","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.06","url":null,"abstract":"In this research, preparation of methacrylic acid-acrylamide based ZnO hydrogel nanocomposite (MAA-AM)/ZnO hydrogel nanocomposite by way of co-polymerization via used acrylate acid (AA) (or acrylate salt) (AA) or methacrylic acid (MAA)) and acrylamide (AM). Nanocomposites based on acrylate are characterized via being hydrophilic and able to retain water. Nanocomposite properties were studied using different techniques (FE-SEM, TEM, and EDX). The photocatalytic degradation of methylene blue MB dye under different conditions was studied using nanocomposite like time of irradiation, mass of catalyst (MAA- AM)/ZnO hydrogel nanocomposite, initial MB dye concentration onto photocatalytic degradation and reactivation were studied. The result increases the photocatalytic degradation with the rise weight of catalyst (MAA- AM)/ZnO hydrogel nanocomposite range (0.1–0.25 g). Too, a decrease in photocatalytic degradation was observed with an increase in MB. Observed that after reuse, ((MAA- AM)/ZnO) nanocomposite hydrogel appear photocatalytic efficiency from of the use 1 to 6 cycle 87.88 to 58.87%, showing that ((MAA- AM)/ZnO hydrogel nanocomposite surface appear good stability.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41432499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wedad M. A. Manjil, M. Ilowefah, H. B. Ismail, Hussein L. Algboory
It suggested that phytochemicals found in cereals, legumes and chia possess several health effects. Consequently, this study aimed to investigate the influences of chia-fortified basisa on type II diabetes, total cholesterol and triglycerides. Urea, creatinine, blood pressure and body mass index were also determined. Basisa is a cereal-legumes food that were prepared using wheat, chickpea, lentils, fenugreek, turmeric and cumin in measured ratios. Chia powder was added to basisa by 5 and 10%. The participants were diabetic (type II) with cholesterol and triglycerides elevation. They were divided into three groups according to the chia powder (0, 5 and 10%) used. The study were conducted for 90 days. The results indicated that groups who had basisa with chia had significantly (p ˂ 0.01) low levels of HbA1c, cholesterol, LDL, triglycerides, BMI and blood pressure compared to the control groups after 90 days of the study. Urea and creatinine levels were increased; however, their levels were still in the normal range. It can be concluded chia powder enhanced the positive effects of basisa on chronic diseases and obesity.
{"title":"Investigation of the Effects of Chia-fortified Basisa on Diabetic Patients","authors":"Wedad M. A. Manjil, M. Ilowefah, H. B. Ismail, Hussein L. Algboory","doi":"10.25258/ijpqa.14.2.18","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.18","url":null,"abstract":"It suggested that phytochemicals found in cereals, legumes and chia possess several health effects. Consequently, this study aimed to investigate the influences of chia-fortified basisa on type II diabetes, total cholesterol and triglycerides. Urea, creatinine, blood pressure and body mass index were also determined. Basisa is a cereal-legumes food that were prepared using wheat, chickpea, lentils, fenugreek, turmeric and cumin in measured ratios. Chia powder was added to basisa by 5 and 10%. The participants were diabetic (type II) with cholesterol and triglycerides elevation. They were divided into three groups according to the chia powder (0, 5 and 10%) used. The study were conducted for 90 days. The results indicated that groups who had basisa with chia had significantly (p ˂ 0.01) low levels of HbA1c, cholesterol, LDL, triglycerides, BMI and blood pressure compared to the control groups after 90 days of the study. Urea and creatinine levels were increased; however, their levels were still in the normal range. It can be concluded chia powder enhanced the positive effects of basisa on chronic diseases and obesity.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43508211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The core focus of current research is chemical polysaccharide modification in pharmaceutical applications. The gum is made from the endosperm of Sesbania grandiflora Plant seeds that belongs to family Leguminosae. Both water-soluble and waterinsoluble gum were present in the Sesbania seed powder; the water-soluble gum was removed during purification, yielding a 30% purification yield. In order to increase the applications of partially hydroxypropyl Sesbania gum, the modifications indicated here entail adding hydroxypropyl groups to the molecule under a variety of different conditions. Among the factors that were looked at were the etherifying agent concentration, alkaline volume, and preparation medium parameters, including the reaction time and temperature. The degree of substitution (DS) was raised, which boosted the unaltered gum’s solubility, stability, and viscosity. Increases in an etherifying agent and alkali concentration, volume, reaction duration, and temperature increase DS from 0.4 to 0.7. The finished product was characterized using IR spectroscopy, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, rheologic property, solubility, swelling index, and gel fraction analysis of batch F1 as an improved batch. The alternate method for developing drug-loaded nanoparticles for controlled release dosages form by suing hydroxypropyl Sesbania gum.
{"title":"Synthesis and Characterization of Hydroxypropyl Sesbania Galactamannan Seed Gum for Pharmaceutical Application","authors":"V. Chatap, G. Choudhari, Prashant Jain, M. Bhat","doi":"10.25258/ijpqa.14.2.11","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.11","url":null,"abstract":"The core focus of current research is chemical polysaccharide modification in pharmaceutical applications. The gum is made from the endosperm of Sesbania grandiflora Plant seeds that belongs to family Leguminosae. Both water-soluble and waterinsoluble gum were present in the Sesbania seed powder; the water-soluble gum was removed during purification, yielding a 30% purification yield. In order to increase the applications of partially hydroxypropyl Sesbania gum, the modifications indicated here entail adding hydroxypropyl groups to the molecule under a variety of different conditions. Among the factors that were looked at were the etherifying agent concentration, alkaline volume, and preparation medium parameters, including the reaction time and temperature. The degree of substitution (DS) was raised, which boosted the unaltered gum’s solubility, stability, and viscosity. Increases in an etherifying agent and alkali concentration, volume, reaction duration, and temperature increase DS from 0.4 to 0.7. The finished product was characterized using IR spectroscopy, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, rheologic property, solubility, swelling index, and gel fraction analysis of batch F1 as an improved batch. The alternate method for developing drug-loaded nanoparticles for controlled release dosages form by suing hydroxypropyl Sesbania gum.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42391936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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