Pub Date : 2021-01-15DOI: 10.18231/J.IJPCA.2020.024
D. Dash, N. Chaubey, A. Sahu, Vaibhav Tripathi, L. Pal
Corona viruses are a large family of viruses which may cause illness in animals or humans. In humans, several coronaviruses are known to cause respiratory infections ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS).1,2 Most recently discovered coronavirus causes COVID-19 is the infectious disease caused by the most recently discovered corona virus. This new virus and disease were unknown before the outbreak began in Wuhan, China, in December 2019.3
{"title":"Repurposed application of doxycycline in COVID 19 treatment","authors":"D. Dash, N. Chaubey, A. Sahu, Vaibhav Tripathi, L. Pal","doi":"10.18231/J.IJPCA.2020.024","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2020.024","url":null,"abstract":"Corona viruses are a large family of viruses which may cause illness in animals or humans. In humans, several coronaviruses are known to cause respiratory infections ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS).1,2 Most recently discovered coronavirus causes COVID-19 is the infectious disease caused by the most recently discovered corona virus. This new virus and disease were unknown before the outbreak began in Wuhan, China, in December 2019.3","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"66 1","pages":"151-154"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72855859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-15DOI: 10.18231/J.IJPCA.2020.030
S. Chaudhry
Tinnitus can vary widely with regard to pitch, loudness, description of sound, special localization, and temporal pattern. Tinnitus is sometimes the first sign of hearing loss in older people. It also can be a side effect of various medications (antibiotics, cancer drugs, quinine medications, antidepressants, aspirin) If the condition is left unattended for a prolonged period, it can also lead to psychological problems. Extensive reviews of randomized clinical trials have revealed that only nortriptyline, amitriptyline, alprazolam, clonazepam, and oxazepam are more beneficial than placebo. Keywords: Tinnitus, Sytematic review, Hearing impairment, Antidepressants, Benzodiazepines.
{"title":"Pharmacotherapy of tinnitus","authors":"S. Chaudhry","doi":"10.18231/J.IJPCA.2020.030","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2020.030","url":null,"abstract":"Tinnitus can vary widely with regard to pitch, loudness, description of sound, special localization, and temporal pattern. Tinnitus is sometimes the first sign of hearing loss in older people. It also can be a side effect of various medications (antibiotics, cancer drugs, quinine medications, antidepressants, aspirin) If the condition is left unattended for a prolonged period, it can also lead to psychological problems. Extensive reviews of randomized clinical trials have revealed that only nortriptyline, amitriptyline, alprazolam,\u0000clonazepam, and oxazepam are more beneficial than placebo.\u0000\u0000Keywords: Tinnitus, Sytematic review, Hearing impairment, Antidepressants, Benzodiazepines.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"52 1","pages":"188-191"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73017240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-15DOI: 10.18231/2394-2797.2018.0011
D. Rishipathak, Luketa Alai, P. Udavant
Several new promising bioactive derivatives of N-(5-(Substituted)-1, 3, 4-thiadiazol-2-yl)-2-((5-(substitutes)-4H-1, 2, 4-triazol-3-yl) amino) acetamide were synthesized. The compounds were obtained in excellent yields. The synthesized compounds were confirmed on the basis of IR and NMR. Acute toxicity study was done to determine the LD50 of the newly synthesized compounds. Some of the synthesized compounds were evaluated for their anticonvulsant effect by PTZ induced convulsions method. Statistical testing was done by one way ANOVA followed by Dunnett’s test. The compounds D-III showed the highest percentage of protection as compared to PTZ, i.e. 80% at the dose of 20mg/kg among the evaluated compounds compared to control. Keywords: 1, 3, 4-thiadiazole, 1, 2, 4-triazole, Anticonvulsant
{"title":"Synthesis and evaluation for anticonvulsant activity of some N-(5-(substituted)-1,3,4-thiadiazol-2-yl)-2-((5-(substituted)-4H-1,2,4-triazol-3-yl)-amino) acetamide derivatives","authors":"D. Rishipathak, Luketa Alai, P. Udavant","doi":"10.18231/2394-2797.2018.0011","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0011","url":null,"abstract":"Several new promising bioactive derivatives of N-(5-(Substituted)-1, 3, 4-thiadiazol-2-yl)-2-((5-(substitutes)-4H-1, 2, 4-triazol-3-yl) amino) acetamide were synthesized. The compounds were obtained in excellent yields. The synthesized compounds were confirmed on the basis of IR and NMR. Acute toxicity study was done to determine the LD50 of the newly synthesized compounds. Some of the synthesized compounds were evaluated for their anticonvulsant effect by PTZ induced convulsions method. Statistical testing was done by one way ANOVA followed by Dunnett’s test. The compounds D-III showed the highest percentage of protection as compared to PTZ, i.e. 80% at the dose of 20mg/kg among the evaluated compounds compared to control.\u0000\u0000Keywords: 1, 3, 4-thiadiazole, 1, 2, 4-triazole, Anticonvulsant","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"83 1","pages":"67-73"},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76183351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-15DOI: 10.18231/2394-2797.2018.0009
Sachinthi S. Amarasiri, A. Attanayake, K. Jayatilaka, L. Mudduwa
Animals are used as experimental models to reproduce human diseases. To date, various animal models have been successfully developed by numerous methods to simulate human diseases including chronic kidney disease (CKD). Such models have played a central role in developing dialysis, transplantation experiments and more importantly in the discovery of new therapeutic agents from natural product for the care of patients with kidney disease. This review focuses on key information on in vivo models of CKD that have been developed through spontaneous, acquired and genetic approaches. Most of the experiments related to CKD have been carried out on rodent models such as mice and rats. Spontaneous disease models of CKD are generated by various metabolic and immunological methods. Nephrotoxic agents including adenine, adriamycin, cisplatin, folic acid, aristolochic acid and oxalate are used to induce CKD in addition to nephrectomy and unilateral ureteral obstruction models. Further, animal models developed through forward and reverse genetic approaches provide artificial models of CKD. Developing animal models to approximate human CKD is a challenging task since it requires reflecting the effect of age, sex, and comorbidities in addition to the disease condition. But, their usage to tease out the processes which can cause pathologic changes in a biological system is still important for the health care improvements related to CKD. However, no animal model can exactly simulate response in human CKD. Keywords: Acquired methods, Animal models, Chronic kidney disease, Genetic approaches, Nephrotoxic agents, Spontaneous models
{"title":"Animal models of chronic kidney disease: Screening tool to investigate nephroprotective effects of natural products","authors":"Sachinthi S. Amarasiri, A. Attanayake, K. Jayatilaka, L. Mudduwa","doi":"10.18231/2394-2797.2018.0009","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0009","url":null,"abstract":"Animals are used as experimental models to reproduce human diseases. To date, various animal models have been successfully developed by numerous methods to simulate human diseases including chronic kidney disease (CKD). Such models have played a central role in developing dialysis, transplantation experiments and more importantly in the discovery of new therapeutic agents from natural product for the care of patients with kidney disease. This review focuses on key information on in vivo models of CKD that have been developed through spontaneous, acquired and genetic approaches. Most of the experiments related to CKD have been carried out on rodent models such as mice and rats. Spontaneous disease models of CKD are generated by various metabolic and immunological methods. Nephrotoxic agents including adenine, adriamycin, cisplatin, folic acid, aristolochic acid and oxalate are used to induce CKD in addition to nephrectomy and unilateral ureteral obstruction models. Further, animal models developed through forward and reverse genetic approaches provide artificial models of CKD. Developing animal models to approximate human CKD is a challenging task since it requires reflecting the effect of age, sex, and comorbidities in addition to the disease condition. But, their usage to tease out the processes which can cause pathologic changes in a biological system is still important for the health care improvements related to CKD. However, no animal model can exactly simulate response in human CKD.\u0000\u0000Keywords: Acquired methods, Animal models, Chronic kidney disease, Genetic approaches, Nephrotoxic agents, Spontaneous models","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"25 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84764783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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