Pub Date : 2020-05-15DOI: 10.18231/j.ijpca.2020.006
M. Shahnaz, Shivani Sharma, Anchal Sharma, D. Prasad
Precision: The degree of agreement among individual test results when a method is applied to multiple samplings of a homogeneous sample. It is a measure of either the degree of reproducibility (agreement under different conditions) or of repeatability (agreement under same condition) of the method. Linearity: The ability of a method to produce results that is directly or indirectly proportional to the conc. of the analyte in samples within a given range. Range: The interval between upper and lower level of analyte (including those levels) that has been shown to be determined with precision, accuracy and linearity using the method as written. Accuracy: The closeness of test results obtained by method to the true value. It is a measure of the exactness of the method. Ruggedness: The ruggedness of an analytical method is the degree of reproducibility of test results obtained by analysis of the same samples under a variety of normal test conditions. Such as different laboratories, different analyst, different instruments, different lots of reagents different elapsed assay times, differently days at normal lab. Conditions etc. Intermediate precision is normally expressed as the lack of influence on test results of operational and environmental variables of the analytical method. Ultraviolet Visible spectrometric assay developed for the quantification of Ketoprofen was performed in methanol in the concentration of 10 mcgml. Single Point Standardization method was used for the quantitative analysis of drug. The drug obeys Lambert – Beer’s law in the concentration range of 5 mcgml. The absorbance maxima occur at 256 nm. The developed method was validated as per ICH norms. Single Point Standardization method involves simple calculations. The absorbance value at 256 nm was found to be around 0.291. The results obtained on the validation parameters of developed method meets the ICH requirements. It infers that the method was found to be simple, specific, precise, accurate
{"title":"Analytical method development and validation of ketoprofen tablet by UV spectrophotometer","authors":"M. Shahnaz, Shivani Sharma, Anchal Sharma, D. Prasad","doi":"10.18231/j.ijpca.2020.006","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.006","url":null,"abstract":"Precision: The degree of agreement among individual test results when a method is applied to multiple samplings of a homogeneous sample. It is a measure of either the degree of reproducibility (agreement under different conditions) or of repeatability (agreement under same condition) of the method.\u0000Linearity: The ability of a method to produce results that is directly or indirectly proportional to the conc. of the analyte in samples within a given range.\u0000Range: The interval between upper and lower level of analyte (including those levels) that has been shown to be determined with precision, accuracy and linearity using the method as written.\u0000Accuracy: The closeness of test results obtained by method to the true value. It is a measure of the exactness of the method.\u0000Ruggedness: The ruggedness of an analytical method is the degree of reproducibility of test results obtained by analysis of the same samples under a variety of normal test conditions. Such as different laboratories, different analyst, different instruments, different lots of reagents different elapsed assay times, differently days at normal lab. Conditions etc. Intermediate precision is normally expressed as the lack of influence on test results of operational and environmental variables of the analytical method. Ultraviolet Visible spectrometric assay developed for the quantification of Ketoprofen was performed in methanol in the concentration of 10 mcgml. Single Point Standardization method was used for the quantitative analysis of drug. The drug obeys Lambert – Beer’s law in the concentration range of 5 mcgml. The absorbance maxima occur at 256 nm. The developed method was validated as per ICH norms. Single Point Standardization method involves simple calculations. The absorbance value at 256 nm was found to be around 0.291. The results obtained on the validation parameters of developed method meets the ICH requirements. It infers that the method was found to be simple, specific, precise, accurate","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"43 1","pages":"39-50"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75139652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.18231/j.ijpca.2020.003
B. Dabbir, Nanjundaiah Ks
Mycoplasmosis in small ruminants is considered an economically important respiratory infection resulting in huge economic losses. Small ruminant mycoplasmosis is prevalent worldwide. Chemotherapeutic efficacy With Tylosin, Moxifloxacin injections and Azithromycin oral solution, in 2014 affected goats were studied. It was observed that solitary and dual combinations increased the cure rate and saved the affected goats. The percentage of cure was more in combinations than single Tylosin injection. The combination of Moxifloxacin and Azithrmycin was very effective with a 93% cure percentage. Keywords: Mycoplasma, Sheep, Tylosin, Moxifloxacin, Azithromycin.
{"title":"Chemotherapy of mycoplasmosis in sheep and goats","authors":"B. Dabbir, Nanjundaiah Ks","doi":"10.18231/j.ijpca.2020.003","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.003","url":null,"abstract":"Mycoplasmosis in small ruminants is considered an economically important respiratory infection resulting in huge economic losses. Small ruminant mycoplasmosis is prevalent worldwide. Chemotherapeutic efficacy With Tylosin, Moxifloxacin injections and Azithromycin oral solution, in 2014 affected goats were studied. It was observed that solitary and dual combinations increased the cure rate and saved the affected goats. The percentage of cure was more in combinations than single Tylosin injection. The combination of Moxifloxacin and Azithrmycin was very effective with a 93% cure percentage.\u0000\u0000Keywords: Mycoplasma, Sheep, Tylosin, Moxifloxacin, Azithromycin.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"5 1","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76580542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.18231/j.ijpca.2020.002
Apeksha R Rathi, R. Popat, V. Adhao, V. Shrikhande
The nail is horny structure. Nail plate is responsible for penetration of drug across it. As it is hard enough the penetration becomes difficult, only a fraction of topical drug penetrates across it. Hence the effective therapeutic concentration is not achieved. The nail plate may appear abnormal as a result of decreased glow. It`s involvement of nail bed, reduction of blood supply, physical or chemical features of nail bed. As a result variety of diseases occurs.1 Oral therapies are accompanied by systemic side effects and drug interactions, while topical therapies are limited by the low permeation rate through the nail plate. These diseases can be cured by achieving desired therapeutic concentration of drug by nail drug delivery system. Human nails do not have only protective and decorative role, but can also be considered as an alternative pathway for drug delivery, especially in nail diseases such as onychomycosis or psoriasis. The physical techniques (manual and electrical nail abrasion, acid etching, ablation by lasers, microporation, application of low-frequency ultrasound and electric currents) and chemicals (thiols, sulphites, hydrogen peroxide, urea, water, enzymes) that have shown ungual enhance reactivity. For effective topical therapy, fungal drug permeation must be enhanced.3 This can be achieved by disrupting the nail plate using physical techniques or chemical agents. Alternatively, drug permeation into the intact nail plate may be encouraged, for example, by iontophoresis or by formulating the drug within a vehicle which enables high drug partition out of the vehicle and into the nail plate. Keywords: Nail drug delivery, Onychomycosis, Iontophoresis, Psoriasis.
{"title":"Nail drug delivery system a review","authors":"Apeksha R Rathi, R. Popat, V. Adhao, V. Shrikhande","doi":"10.18231/j.ijpca.2020.002","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.002","url":null,"abstract":"The nail is horny structure. Nail plate is responsible for penetration of drug across it. As it is hard enough the penetration becomes difficult, only a fraction of topical drug penetrates across it. Hence the effective therapeutic concentration is not achieved. The nail plate may appear abnormal as a result of decreased glow. It`s involvement of nail bed, reduction of blood supply, physical or chemical features of nail bed. As a result variety of diseases occurs.1 Oral therapies are accompanied by systemic side effects and drug interactions, while topical therapies are limited by the low permeation rate through the nail plate. These diseases can be cured by achieving desired therapeutic concentration of drug by nail drug delivery system. Human nails do not have only protective and decorative role, but can also be considered as an alternative pathway for drug delivery, especially in nail diseases such as onychomycosis or psoriasis. The physical techniques (manual and electrical nail abrasion, acid etching, ablation by lasers, microporation, application of low-frequency ultrasound and electric currents) and chemicals (thiols, sulphites, hydrogen peroxide, urea, water, enzymes) that have shown ungual enhance reactivity. For effective topical therapy, fungal drug permeation must be enhanced.3 This can be achieved by disrupting the nail plate using physical techniques or chemical agents. Alternatively, drug permeation into the intact nail plate may be encouraged, for example, by iontophoresis or by formulating the drug within a vehicle which enables high drug partition out of the vehicle and into the nail plate.\u0000\u0000Keywords: Nail drug delivery, Onychomycosis, Iontophoresis, Psoriasis.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"31 1","pages":"9-21"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82166114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.18231/j.ijpca.2020.008
A. Okpogba, E. Ogbodo, I. Ezeugwunne, R. Analike, A. Amah, CG Ikimi, I. Ejiogu, E. Onyeneke
Background of Study: Heavy metal contamination and exposure in work environment is an issue of great public health implication. Aim of the Study: this cross sectional study assessed the renal function status in occupationally exposed people working in metal fabricating factory in Nnewi South Eastern Nigeria. Materials and Methods: A total of 15 apparently healthy individuals in metal fabricating factory aged between 19 and 56 years and 79 control subjects (comprising of 39 control subjects from Nnewi (N) and 40 control subjects from Elele (E) respectively) aged between 18 and 44 years were recruited for the study. 5ml of venous blood sample was collected from each subject for the determination of biochemical parameters (potassium, sodium, chloride, bicarbonate, urea and creatinine levels) using standard laboratory methods. Results: The current study showed significantly elevated levels of sodium, potassium, urea and creatinine (p Conclusion: This study revealed the deleterious effect of heavy metal exposure at the work place on the functionality of the kidneys. Keywords: Metal fabrication, Factory workers, Occupational exposure, Heavy metals, Kidney function, Body mass index, Length of service, Age.
{"title":"Assessment of the renal function status in occupationally exposed people working in metal fabricating factory in Nnewi","authors":"A. Okpogba, E. Ogbodo, I. Ezeugwunne, R. Analike, A. Amah, CG Ikimi, I. Ejiogu, E. Onyeneke","doi":"10.18231/j.ijpca.2020.008","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.008","url":null,"abstract":"Background of Study: Heavy metal contamination and exposure in work environment is an issue of great public health implication.\u0000Aim of the Study: this cross sectional study assessed the renal function status in occupationally exposed people working in metal fabricating factory in Nnewi South Eastern Nigeria.\u0000Materials and Methods: A total of 15 apparently healthy individuals in metal fabricating factory aged between 19 and 56 years and 79 control subjects (comprising of 39 control subjects from Nnewi (N) and 40 control subjects from Elele (E) respectively) aged between 18 and 44 years were recruited for the study. 5ml of venous blood sample was collected from each subject for the determination of biochemical parameters (potassium, sodium, chloride, bicarbonate, urea and creatinine levels) using standard laboratory methods.\u0000Results: The current study showed significantly elevated levels of sodium, potassium, urea and creatinine (p\u0000Conclusion: This study revealed the deleterious effect of heavy metal exposure at the work place on the functionality of the kidneys. \u0000\u0000Keywords: Metal fabrication, Factory workers, Occupational exposure, Heavy metals, Kidney function, Body mass index, Length of service, Age.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"1 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83041482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.18231/j.ijpca.2020.007
G. Chawla, Muhamad Thufail
Di-Schiff’s bases are normally synthesized from aldehyde and diamine using organic solvents under conditions that remove water azeotropically. Here is a report for the preparation of di-Schiff’s base using both the conventional method and pure water without a catalyst and results were compared. It was observed that yields are better and reaction time is comparatively less when water is used as a solvent. Keywords: Benzene, Water, Green chemistry.
{"title":"Syntheses of di-Schiff’s bases: A comparative study using benzene and water (concept of green chemistry) as solvents","authors":"G. Chawla, Muhamad Thufail","doi":"10.18231/j.ijpca.2020.007","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.007","url":null,"abstract":"Di-Schiff’s bases are normally synthesized from aldehyde and diamine using organic solvents under conditions that remove water azeotropically. Here is a report for the preparation of di-Schiff’s base using both the conventional method and pure water without a catalyst and results were compared. It was observed that yields are better and reaction time is comparatively less when water is used as a solvent.\u0000\u0000Keywords: Benzene, Water, Green chemistry.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"82 1","pages":"51-53"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83930097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.18231/j.ijpca.2020.001
P. Jain, Santosh B. Bodkhe, Urmila R. Salunke, N. G. Haswani
Aripiprazole is second generation anti-psychotic drug. Numerous investigations that have been published previously; stating analytical methods. The reported investigations for aripiprazole in its medical preparation and biological matrices is in present report. The most widely employed approaches in analysis outlined, such as spectrometric, liquid chromatographic processes, liquid chromatography-mass spectrometry, voltammetry and gas chromatography (GC). Spectrometric methods for ARP alone and in combination are precisely stated. Which includes parameters like ? max, solvent, matrix etc. and HPLC methods for aripiprazole single and in combination are given in tabular form, to parameters like matrix, stationary phase, mobile phase composition detection wavelength etc. HPTLC methods are reported in tabular form contain parameters like mobile phase combination, stationary phase, Rf etc. LC-MS method of aripiprazole and metabolite including parameter like matrix, stationary phase, mobile phase, internal standard, flow rate, retention time etc. the statistical data regarding the utility of these methods for estimation of aripiprazole published during 2004 to 2019 is precisely presented herein assist in further analytical and formulation research in future. Keywords: Aripiprazole, Pharmaceutical, Analytical methods, Applications, Scope, Review.
{"title":"Pharmaceutical estimation of aripiprazole to assist in modern research: An upbeat review","authors":"P. Jain, Santosh B. Bodkhe, Urmila R. Salunke, N. G. Haswani","doi":"10.18231/j.ijpca.2020.001","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.001","url":null,"abstract":"Aripiprazole is second generation anti-psychotic drug. Numerous investigations that have been published previously; stating analytical methods. The reported investigations for aripiprazole in its medical preparation and biological matrices is in present report. The most widely employed approaches in analysis outlined, such as spectrometric, liquid chromatographic processes, liquid chromatography-mass spectrometry, voltammetry and gas chromatography (GC). Spectrometric methods for ARP alone and in combination are precisely stated. Which includes parameters like ? max, solvent, matrix etc. and HPLC methods for aripiprazole single and in combination are given in tabular form, to parameters like matrix, stationary phase, mobile phase composition detection wavelength etc. HPTLC methods are reported in tabular form contain parameters like mobile phase combination, stationary phase, Rf etc. LC-MS method of aripiprazole and metabolite including parameter like matrix, stationary phase, mobile phase, internal standard, flow rate, retention time etc. the statistical data regarding the utility of these methods for estimation of aripiprazole published during 2004 to 2019 is precisely presented herein assist in further analytical and formulation research in future. \u0000\u0000Keywords: Aripiprazole, Pharmaceutical, Analytical methods, Applications, Scope, Review.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"38 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87465647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.18231/j.ijpca.2019.020
Sarishti Sharma, A. Bhatia, Neeru Gakkhar
Nanotechnology is the study and use of structures between 1 nanometer and 100 nanometers in size. Cancer is the leading cause of death among people younger than 85 years. Nanoparticles that deliver chemotherapy drugs directly to cancer cells are under development. Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials also appeal to researchers in the areas of cancer diagnosis and biomarker discovery. Among the newly developed nanomedicine and nanodevices such as quantum dots, nanowires, nanotubes, nanocantilevers, and nanopores, nanoshells and nanoparticles are the most promising applications for various cancer treatments. This article aims at giving an overview of the present status of nanotechnology in cancer therapy and the prospects of nanomaterials as drug carriers for future clinical applications are also discussed. Keywords: Nanotechnology, Nanomedicine, Application of nanomedicine, Nanomedicine for cancer, Risks of nanotechnology.
{"title":"Nanotechnology in cancer therapy: An overview and perspectives (Review)","authors":"Sarishti Sharma, A. Bhatia, Neeru Gakkhar","doi":"10.18231/j.ijpca.2019.020","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.020","url":null,"abstract":"Nanotechnology is the study and use of structures between 1 nanometer and 100 nanometers in size. Cancer is the leading cause of death among people younger than 85 years. Nanoparticles that deliver chemotherapy drugs directly to cancer cells are under development. Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials also appeal to researchers in the areas of cancer diagnosis and biomarker discovery. Among the newly developed nanomedicine and nanodevices such as quantum dots, nanowires, nanotubes, nanocantilevers, and nanopores, nanoshells and nanoparticles are the most promising applications for various cancer treatments. This article aims at giving an overview of the present status of nanotechnology in cancer therapy and the prospects of nanomaterials as drug carriers for future clinical applications are also discussed.\u0000\u0000Keywords: Nanotechnology, Nanomedicine, Application of nanomedicine, Nanomedicine for cancer, Risks of nanotechnology.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"136 1","pages":"110-114"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77809434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.18231/j.ijpca.2019.023
V. Prakash
Introduction: Due to substantial increase of coronary heart disease, a need for identifying and correcting the conventional risk factors like hypertension, diabetes mellitus, smoking and hyperlipidemia has been emerged, as controlling them not only prevents the formation of atheromatous plaque but also slows down its progression and even promotes regression. AIM: Comparing the effects of Terminalia arjuna with Rosuvastatin on triglycerides and high density lipoprotein cholesterol in dyslipidemic patients of either sex. Materials and Methods: A 12 weeks open prospective randomized controlled study, enrolling 60 patients of dyslipidemia was conducted. Patients were distributed in two groups of 30 each. Group A was given Rosuvastatin (10mg) once daily and group B was given Terminalia arjuna (500mg) twice daily. Triglyceride and HDL-C levels were done at baseline and after 4, 8 and 12 weeks of starting the treatment and data was statistically analyzed. Results: Greater reduction in mean Triglyceride level was demonstrared with Terminali arjuna as compared to Rosuvastatin (-35.23±37.59 vs -13.30±6.64), (-51.66±48.67 vs -25.23±11.29) and (-60.63±49.93 vs-35.16±14.76) at 4, 8 and 12 weeks respectively and the difference between both the groups was statistically significant (p2.37±2.20vs 1.97±1.40) at 4 weeks but was slightly less (3.43±2.88 vs 3.53±2.31) and (4.37±2.76 vs 4.77±2.40) at 8 and 12 weeks. On comparing difference was found to be statistically non-significant. Conclusion: Rosuvastatin and Terminalia arjuna both are effective hypolipidemic agents causing significant decrease in triglyceride and increase in high density lipoprotein cholesterol. Terminalia arjuna had showed greater reduction triglyceride and was found to be safe. Keywords: Rosuvastatin, Terminalia arjuna, High density lipoprotein cholesterol, Triglyceride.
引言:由于冠心病的大量增加，对高血压、糖尿病、吸烟、高脂血症等常规危险因素的识别和纠正的需求已经显现出来，因为控制这些危险因素不仅可以防止动脉粥样硬化斑块的形成，而且可以减缓其进展，甚至促进其消退。目的:比较阿终与瑞舒伐他汀对男女血脂异常患者甘油三酯和高密度脂蛋白胆固醇的影响。材料与方法:对60例血脂异常患者进行为期12周的开放前瞻性随机对照研究。患者分为两组，每组30人。A组患者给予瑞舒伐他汀(10mg)每日1次，B组患者给予终叶(500mg)每日2次。甘油三酯和HDL-C水平在基线和开始治疗后4,8和12周进行统计分析。结果:与瑞舒伐他汀相比，终末阿朱那在4周、8周和12周时平均甘油三酯水平的降低幅度更大(-35.23±37.59 vs -13.30±6.64)，(-51.66±48.67 vs -25.23±11.29)和(-60.63±49.93 vs-35.16±14.76)，两组之间的差异在4周时具有统计学意义(p2.37±2.20vs 1.97±1.40)，但在8周和12周时差异略小(3.43±2.88 vs 3.53±2.31)和(4.37±2.76 vs 4.77±2.40)。经比较发现差异无统计学意义。结论:瑞舒伐他汀和终叶都是有效的降血脂药，可显著降低甘油三酯，升高高密度脂蛋白胆固醇。阿尔诸那终草显示出更大的甘油三酯降低，被发现是安全的。关键词:瑞舒伐他汀，终叶，高密度脂蛋白胆固醇，甘油三酯
{"title":"Study comparing the hypolipidemic effects of Terminalia Arjuna with Rosuvastatin on triglyceride and high density lipoprotein- cholesterol levels","authors":"V. Prakash","doi":"10.18231/j.ijpca.2019.023","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.023","url":null,"abstract":"Introduction: Due to substantial increase of coronary heart disease, a need for identifying and correcting the conventional risk factors like hypertension, diabetes mellitus, smoking and hyperlipidemia has been emerged, as controlling them not only prevents the formation of atheromatous plaque but also slows down its progression and even promotes regression.\u0000AIM: Comparing the effects of Terminalia arjuna with Rosuvastatin on triglycerides and high density lipoprotein cholesterol in dyslipidemic patients of either sex.\u0000Materials and Methods: A 12 weeks open prospective randomized controlled study, enrolling 60 patients of dyslipidemia was conducted. Patients were distributed in two groups of 30 each. Group A was given Rosuvastatin (10mg) once daily and group B was given Terminalia arjuna (500mg) twice daily. Triglyceride and HDL-C levels were done at baseline and after 4, 8 and 12 weeks of starting the treatment and data was statistically analyzed.\u0000Results: Greater reduction in mean Triglyceride level was demonstrared with Terminali arjuna as compared to Rosuvastatin (-35.23±37.59 vs -13.30±6.64), (-51.66±48.67 vs -25.23±11.29) and (-60.63±49.93 vs-35.16±14.76) at 4, 8 and 12 weeks respectively and the difference between both the groups was statistically significant (p2.37±2.20vs 1.97±1.40) at 4 weeks but was slightly less (3.43±2.88 vs 3.53±2.31) and (4.37±2.76 vs 4.77±2.40) at 8 and 12 weeks. On comparing difference was found to be statistically non-significant.\u0000Conclusion: Rosuvastatin and Terminalia arjuna both are effective hypolipidemic agents causing significant decrease in triglyceride and increase in high density lipoprotein cholesterol. Terminalia arjuna had showed greater reduction triglyceride and was found to be safe.\u0000\u0000Keywords: Rosuvastatin, Terminalia arjuna, High density lipoprotein cholesterol, Triglyceride.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"59 1","pages":"127-135"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89411663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.18231/j.ijpca.2019.021
Mangesh R Patil, A. Patil, A. Shirkhedkar
The aim of present investigation is to establish simple and economical UV- Spectrophotometric methods for estimation of Tolvaptan using Zero order UV-Spectrophotometric absorbance method and Zero Order- Area under curve (AUC) method with the application of hydrotropic solubilization phenomenon. Tolvaptan is non-peptide vasopressin V2 receptor antagonist. It is completely insoluble in water. Hydrotropic agent, sodium lauryl Sulfate (SLS) 5% w/v was used to enhance the solubility of Tolvaptan. Maximum absorption for Tolvaptan was found to be at 269 nm. The methods are based upon measurement of absorbance at 269 nm and integration of area under curve for analysis of Tolvaptan in the wavelength range of 263.2-282.2 nm. The drug followed linearity in the concentration range of 3 - 18 µg/mL with correlation coefficient value r2> 0.99 for both methods. The proposed methods were validated for accuracy, precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Tolvaptan in pharmaceutical formulation and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Tolvaptan in bulk and tablets. Keywords: Sodium Lauryl Sulphate, Tolvaptan, UV- Spectrophotometry - Area under Curve, UV-Spectrophotometry, Hydrotropy .
{"title":"Novel and ecofriendly UV-Spectrophotometry methods for estimation of Tolvaptan using hydrotropic agent","authors":"Mangesh R Patil, A. Patil, A. Shirkhedkar","doi":"10.18231/j.ijpca.2019.021","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.021","url":null,"abstract":"The aim of present investigation is to establish simple and economical UV- Spectrophotometric methods for estimation of Tolvaptan using Zero order UV-Spectrophotometric absorbance method and Zero Order- Area under curve (AUC) method with the application of hydrotropic solubilization phenomenon. Tolvaptan is non-peptide vasopressin V2 receptor antagonist. It is completely insoluble in water. Hydrotropic agent, sodium lauryl Sulfate (SLS) 5% w/v was used to enhance the solubility of Tolvaptan. Maximum absorption for Tolvaptan was found to be at 269 nm. The methods are based upon measurement of absorbance at 269 nm and integration of area under curve for analysis of Tolvaptan in the wavelength range of 263.2-282.2 nm. The drug followed linearity in the concentration range of 3 - 18 µg/mL with correlation coefficient value r2> 0.99 for both methods. The proposed methods were validated for accuracy, precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Tolvaptan in pharmaceutical formulation and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Tolvaptan in bulk and tablets.\u0000\u0000Keywords: Sodium Lauryl Sulphate, Tolvaptan, UV- Spectrophotometry - Area under Curve, UV-Spectrophotometry, Hydrotropy .","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"96 2 1","pages":"115-119"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87690867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.18231/j.ijpca.2019.017
D. Dash, A. Sahu, R. Panik, K. Mishra, P. Kashyap, Vaibhav Tripathi
Sickle cell anaemia (SCA) has been recognized as a serious genetic disorder throughout the World. This genetic abnormality arises at the sixth position of β-chain of haemoglobin, where amino acid valine is replaced by glutamic acid. SCA has already been announced as an endemic in Chhattisgarh state. Chhattisgarh is well known for its enriched source of herbal plants. People use herbal system of medicine for the management of sickle cell anaemia. Folk healers have sound knowledge of herbal and food plants and they have been practicing such nutraceuticals on sickle anaemic patients for many years. Present review is all about reported and traditional herb. Moreover, we have performed phytochemical screening of some traditional herbs which are being used by the healer’s. on the basis of screening data we have compared the bio-constituents of both reported and traditional herbs. Thus, the present work has encompassed review as well as comparative data. This paper will be beneficial for the new budding researchers for the further assessment of such plants for their anti-sickling activity. Keywords: Sickle cell anaemia, Endemic, Traditional healers, Nutraceuticals, Phytochemical screening.
{"title":"Comparative screening of anti-sickling reported and traditional herbs found in Chhattisgarh","authors":"D. Dash, A. Sahu, R. Panik, K. Mishra, P. Kashyap, Vaibhav Tripathi","doi":"10.18231/j.ijpca.2019.017","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.017","url":null,"abstract":"Sickle cell anaemia (SCA) has been recognized as a serious genetic disorder throughout the World. This genetic abnormality arises at the sixth position of β-chain of haemoglobin, where amino acid valine is replaced by glutamic acid. SCA has already been announced as an endemic in Chhattisgarh state. Chhattisgarh is well known for its enriched source of herbal plants. People use herbal system of medicine for the management of sickle cell anaemia. Folk healers have sound knowledge of herbal and food plants and they have been practicing such nutraceuticals on sickle anaemic patients for many years. Present review is all about reported and traditional herb. Moreover, we have performed phytochemical screening of some traditional herbs which are being used by the healer’s. on the basis of screening data we have compared the bio-constituents of both reported and traditional herbs. Thus, the present work has encompassed review as well as comparative data. This paper will be beneficial for the new budding researchers for the further assessment of such plants for their anti-sickling activity.\u0000\u0000Keywords: Sickle cell anaemia, Endemic, Traditional healers, Nutraceuticals, Phytochemical screening.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"11 1","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73128955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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