Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232537
Aseem Sharma, M. Gautam, K. Godse, Richa Sharma, Padmavathi Surapaneni, M. Agrawal
Background: Acne is a common skin disorder that affects both adolescents and adults and is categorized as an inflammatory dermatosis. Persistent adult acne is prevalent in more than 80% of cases. Chemical peels are widely used in acne therapy due to their various benefits, including exfoliation, acne lesion reduction, complexion radiance improvement, and scar repair. The procedure, consisting of 2 to 8 sessions, is ideal for adult women with oily skin, acne breakouts, and concerns about photoaging and complexion radiance. Methods: A cohort of Indian dermatologists were provided a questionnaire related to the quantum of weekly acne patients seen and their clinical expertise regarding the use of Sebium Night Peel containing 15% glycolic acid, the Fluidactiv™ patented complex & D-panthenol. These results were later analyzed using a standardised visual analogue scale. Results: The study enrolled 826 patients, and complete responses were received from 73 dermatologists practicing clinical and aesthetic dermatology across major cities in India. The study revealed that 97% of dermatologists would recommend the Sebium Night Peel as a chemical peel for patients with acne and acne-related complications. The majority of dermatologists rated the peel's tolerability and safety as "good" across various evaluation criteria. Additionally, 97% of dermatologists reported no safety concerns associated with the Sebium Night Peel. Conclusions: This study establishes the Sebium Night Peel as a preferred and effective chemical peel for managing acne-prone skin and associated conditions, as endorsed by dermatologists across India.
{"title":"A multicentric, prospective, observational study evaluating the use patterns of Sebium night peel for acne-prone skin and associated conditions","authors":"Aseem Sharma, M. Gautam, K. Godse, Richa Sharma, Padmavathi Surapaneni, M. Agrawal","doi":"10.18203/issn.2455-4529.intjresdermatol20232537","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232537","url":null,"abstract":"Background: Acne is a common skin disorder that affects both adolescents and adults and is categorized as an inflammatory dermatosis. Persistent adult acne is prevalent in more than 80% of cases. Chemical peels are widely used in acne therapy due to their various benefits, including exfoliation, acne lesion reduction, complexion radiance improvement, and scar repair. The procedure, consisting of 2 to 8 sessions, is ideal for adult women with oily skin, acne breakouts, and concerns about photoaging and complexion radiance.\u0000Methods: A cohort of Indian dermatologists were provided a questionnaire related to the quantum of weekly acne patients seen and their clinical expertise regarding the use of Sebium Night Peel containing 15% glycolic acid, the Fluidactiv™ patented complex & D-panthenol. These results were later analyzed using a standardised visual analogue scale.\u0000Results: The study enrolled 826 patients, and complete responses were received from 73 dermatologists practicing clinical and aesthetic dermatology across major cities in India. The study revealed that 97% of dermatologists would recommend the Sebium Night Peel as a chemical peel for patients with acne and acne-related complications. The majority of dermatologists rated the peel's tolerability and safety as \"good\" across various evaluation criteria. Additionally, 97% of dermatologists reported no safety concerns associated with the Sebium Night Peel.\u0000Conclusions: This study establishes the Sebium Night Peel as a preferred and effective chemical peel for managing acne-prone skin and associated conditions, as endorsed by dermatologists across India.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76629147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232544
Vivekananda Ittigi
The treatment of keloid has been a challenge, and at times, frustrating because of the recurrence. Hence, it is essential to find treatment modality with least recurrence and good cosmetic results. This study showed the effect of topical 5-fluorouracil following carbon dioxide (CO2) laser excision on recurrence of keloid. Case series of Total 24 patients (20 females and 4 males) of age group 12-56 years having keloid of duration 1-8 years were included in this study. Lesions were present on ear lobes, shoulder, chest, leg. CO2 laser was used in continuous mode to excise the lesions and all patients advised topical 5-FU (5%) once daily application over the lesion in the night, once re-epithelization started, for 4 weeks. The patients were followed up initially at every week for 4 weeks then every 4 weeks for 24 weeks to evaluate the response of treatment. Of the 24 patients evaluated at 24 weeks, none (0%) showed any sign of recurrence. Out of 22 patients four (18.2%) patients complained of burning sensation/irritation. Three (13.6%) patients of erythema and erosion which cleared with temporary discontinuation of topical 5-FU and completed the 4 weeks of topical therapy. Three (13.6%) patients developed hypopigmentation. Though response of this combination is encouraging in prevention of recurrence of keloid, recurrence on long term follow up need to be observed.
{"title":"Case series of combination of carbon dioxide laser and topical 5-flourouracil for prevention of recurrence of keloid","authors":"Vivekananda Ittigi","doi":"10.18203/issn.2455-4529.intjresdermatol20232544","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232544","url":null,"abstract":"The treatment of keloid has been a challenge, and at times, frustrating because of the recurrence. Hence, it is essential to find treatment modality with least recurrence and good cosmetic results. This study showed the effect of topical 5-fluorouracil following carbon dioxide (CO2) laser excision on recurrence of keloid. Case series of Total 24 patients (20 females and 4 males) of age group 12-56 years having keloid of duration 1-8 years were included in this study. Lesions were present on ear lobes, shoulder, chest, leg. CO2 laser was used in continuous mode to excise the lesions and all patients advised topical 5-FU (5%) once daily application over the lesion in the night, once re-epithelization started, for 4 weeks. The patients were followed up initially at every week for 4 weeks then every 4 weeks for 24 weeks to evaluate the response of treatment. Of the 24 patients evaluated at 24 weeks, none (0%) showed any sign of recurrence. Out of 22 patients four (18.2%) patients complained of burning sensation/irritation. Three (13.6%) patients of erythema and erosion which cleared with temporary discontinuation of topical 5-FU and completed the 4 weeks of topical therapy. Three (13.6%) patients developed hypopigmentation. Though response of this combination is encouraging in prevention of recurrence of keloid, recurrence on long term follow up need to be observed.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77972853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232535
M. Devi, K. Saxena, Swosti Mohanty, G. Choudhary
Background: Melasma is a common pigmentary disorder which presents with brown coloured macules that occurs around the sun-exposed areas of the skin, particularly on the face. Many treatment modalities are present but often it is resistant to treatment. The aim of our study was to compare the therapeutic efficacy and safety of tranexamic acid administered by oral and topical route in patients of melasma. Methods: Our study was a prospective, randomised study which consisted of 40 new melasma patients. 20 patients were given Oral Tranexamic acid 250 mg twice daily, classified as Group 1, other 20 patients were given topical Tranexamic acid (3%) twice a day (fully covering the lesion), classified as Group 2 for a period of 8 weeks and both were given broad spectrum sunscreen (SPF 50). MASI was determined before starting treatment (baseline), 4 weeks and 8 weeks. Based on the reduction in the mean MASI, the therapeutic response is graded and subjective response and adverse effects were also recorded at each visit. Results: Mean percentage reduction in MASI scores was higher in oral (52.1%) as compared to topical (31.9%) group. In oral group, headache was the only adverse effect, however, in topical group, erythema, burning, acneiform eruptions were reported. At final assessment, fair improvement was seen in both groups. Conclusions: Both oral as well as topical tranexamic acid were efficacious for treatment of melasma, however, of the two oral tranexamic acid was safer and provided a better proportional response.
{"title":"Comparison of efficacy of oral and topical route of tranexamic acid in patients of melasma","authors":"M. Devi, K. Saxena, Swosti Mohanty, G. Choudhary","doi":"10.18203/issn.2455-4529.intjresdermatol20232535","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232535","url":null,"abstract":"Background: Melasma is a common pigmentary disorder which presents with brown coloured macules that occurs around the sun-exposed areas of the skin, particularly on the face. Many treatment modalities are present but often it is resistant to treatment. The aim of our study was to compare the therapeutic efficacy and safety of tranexamic acid administered by oral and topical route in patients of melasma.\u0000Methods: Our study was a prospective, randomised study which consisted of 40 new melasma patients. 20 patients were given Oral Tranexamic acid 250 mg twice daily, classified as Group 1, other 20 patients were given topical Tranexamic acid (3%) twice a day (fully covering the lesion), classified as Group 2 for a period of 8 weeks and both were given broad spectrum sunscreen (SPF 50). MASI was determined before starting treatment (baseline), 4 weeks and 8 weeks. Based on the reduction in the mean MASI, the therapeutic response is graded and subjective response and adverse effects were also recorded at each visit.\u0000Results: Mean percentage reduction in MASI scores was higher in oral (52.1%) as compared to topical (31.9%) group. In oral group, headache was the only adverse effect, however, in topical group, erythema, burning, acneiform eruptions were reported. At final assessment, fair improvement was seen in both groups.\u0000Conclusions: Both oral as well as topical tranexamic acid were efficacious for treatment of melasma, however, of the two oral tranexamic acid was safer and provided a better proportional response.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75588313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232539
M. Gala, Snehal Muchhala, Akhila Paspulate, R. Rathod, K. Veligandla, B. Aich, Arti Sanghavi, Nilesh Guhe
Background: Consumers worldwide are concerned about their diet, health, lifestyle, and hair care. Considering hair care is a crucial part of daily beauty routines, this survey aims to evaluate the effects of Mintop Shampoo (containing Procapil 1% and Redensyl 1%) in women with hair fall. Methods: A total of 165 females were enrolled in the survey, as per the study inclusion/exclusion criteria. Mintop shampoo (test product) was provided to the study participants and were instructed to use the product at home for a period of 30 days. The data was collected using a Consumer survey Questionnaire. A self-assessment questionnaire was filled out at the end of the survey and collected from participants. The percentage of participants reporting top 3 scores (on a 5-point scale) was considered for data analysis. Results: 93.33 % of participants agreed that the product was effective in slowing down hair fall, and 93.94% of participants agreed that the product was effective in reducing the dryness of hair. 93.94% of participants agreed that the product was effective in improving dull hair to full-life hair (Bounce and Volume). 93.33% of participants agreed that the product was effective in improving the strength of hair. Conclusions: Present study results demonstrated that Mintop shampoo was effective in improving the strength of hair, reducing dryness of hair, and aids slowing down hair fall. Also, no adverse events or Serious Adverse events were reported in the study.
{"title":"A consumer-based survey study on Mintop shampoo in women with hair fall","authors":"M. Gala, Snehal Muchhala, Akhila Paspulate, R. Rathod, K. Veligandla, B. Aich, Arti Sanghavi, Nilesh Guhe","doi":"10.18203/issn.2455-4529.intjresdermatol20232539","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232539","url":null,"abstract":"Background: Consumers worldwide are concerned about their diet, health, lifestyle, and hair care. Considering hair care is a crucial part of daily beauty routines, this survey aims to evaluate the effects of Mintop Shampoo (containing Procapil 1% and Redensyl 1%) in women with hair fall.\u0000Methods: A total of 165 females were enrolled in the survey, as per the study inclusion/exclusion criteria. Mintop shampoo (test product) was provided to the study participants and were instructed to use the product at home for a period of 30 days. The data was collected using a Consumer survey Questionnaire. A self-assessment questionnaire was filled out at the end of the survey and collected from participants. The percentage of participants reporting top 3 scores (on a 5-point scale) was considered for data analysis.\u0000Results: 93.33 % of participants agreed that the product was effective in slowing down hair fall, and 93.94% of participants agreed that the product was effective in reducing the dryness of hair. 93.94% of participants agreed that the product was effective in improving dull hair to full-life hair (Bounce and Volume). 93.33% of participants agreed that the product was effective in improving the strength of hair.\u0000Conclusions: Present study results demonstrated that Mintop shampoo was effective in improving the strength of hair, reducing dryness of hair, and aids slowing down hair fall. Also, no adverse events or Serious Adverse events were reported in the study. ","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75101693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232548
Tanvi Patil, Rajendra Shinde
Epidermolysis bullosa (EB) is a clinically and genetically heterogenous, inherited, mechanobullous disorder characterised by spontaneous or trauma induced blisters over skin and mucous membranes. Four major forms are: EB Simplex, EB Junctional, EB dystrophic and mixed. A 11-year-old and a 9 year old female child, both sisters, accompanied by their father, presented to dermatology OPD, with chief complaints of multiple raw areas over elbows and knees since infancy. There was history of fluid filled lesions which were induced by trauma or friction during handling or while playing. These lesions ruptured on their own or on trauma to form raw areas with crusting which further healed with scarring and small white raised lesions. Also, he gave history of loss of nails following blistering on toes in infancy. No associated systemic complaints were noted. On examination, both of them presented with multiple erosions and ulcers with oozing of blood, few bullae and crusted lesions over elbows, knees and feet. There were multiple atrophic scars and skin coloured to whitish papules [milia] over feet, ankles, elbows and knees. There were loss of nails of toes of both feet. On biopsy, histopathological examination revealed bullae at dermoepidermal junction. Diagnosis of EB junctional was made. EB is a rare inherited disorder. Its management includes prevention and healing of blisters and infection. Psychological support to patients and their families is of prime importance.
{"title":"Epidermolysis bullosa: a tale of two sisters","authors":"Tanvi Patil, Rajendra Shinde","doi":"10.18203/issn.2455-4529.intjresdermatol20232548","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232548","url":null,"abstract":"Epidermolysis bullosa (EB) is a clinically and genetically heterogenous, inherited, mechanobullous disorder characterised by spontaneous or trauma induced blisters over skin and mucous membranes. Four major forms are: EB Simplex, EB Junctional, EB dystrophic and mixed. A 11-year-old and a 9 year old female child, both sisters, accompanied by their father, presented to dermatology OPD, with chief complaints of multiple raw areas over elbows and knees since infancy. There was history of fluid filled lesions which were induced by trauma or friction during handling or while playing. These lesions ruptured on their own or on trauma to form raw areas with crusting which further healed with scarring and small white raised lesions. Also, he gave history of loss of nails following blistering on toes in infancy. No associated systemic complaints were noted. On examination, both of them presented with multiple erosions and ulcers with oozing of blood, few bullae and crusted lesions over elbows, knees and feet. There were multiple atrophic scars and skin coloured to whitish papules [milia] over feet, ankles, elbows and knees. There were loss of nails of toes of both feet. On biopsy, histopathological examination revealed bullae at dermoepidermal junction. Diagnosis of EB junctional was made. EB is a rare inherited disorder. Its management includes prevention and healing of blisters and infection. Psychological support to patients and their families is of prime importance.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135464921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232538
Ayesha Sharmeen, M. Adil, Ravi Kumar
Background: Both extrinsic as well as intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate the disease activity and markers of coagulation cascade in patients of CSU. Methods: A hospital-based, cross-sectional, descriptive study was carried out in 100 patients of chronic urticaria. Baseline D-Dimer, prothrombin time, activated partial thromboplastin time was performed. Disease activity was assessed using Urticaria activity score over 7 days. Results: Of total 100 patients, d-dimer was raised in 72 (72%) patients. Correlation between D-dimer and UAS-7 days showed significant covariance between D-dimer and UAS-7 (p<0.001, r=0.93). Prothrombin time was raised in 55 (55%) patients. Significant correlation was found between PT and UAS-7 (p<0.001, r=0.76). Raised APTT was observed in 61(61%) patients. Correlation between APTT and UAS-7 showed that there was a significant covariance between APTT and UAS-7 (p<0.001, r=0.59). Conclusions: A significant correlation between markers of coagulation cascade and the disease activity in patients of CSU was seen. These markers can help predict the disease severity and possibly monitor therapeutic response.
{"title":"Correlation between disease activity and markers of coagulation cascade in patients of chronic spontaneous urticaria: a hospital based cross-sectional study","authors":"Ayesha Sharmeen, M. Adil, Ravi Kumar","doi":"10.18203/issn.2455-4529.intjresdermatol20232538","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232538","url":null,"abstract":"Background: Both extrinsic as well as intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate the disease activity and markers of coagulation cascade in patients of CSU.\u0000Methods: A hospital-based, cross-sectional, descriptive study was carried out in 100 patients of chronic urticaria. Baseline D-Dimer, prothrombin time, activated partial thromboplastin time was performed. Disease activity was assessed using Urticaria activity score over 7 days.\u0000Results: Of total 100 patients, d-dimer was raised in 72 (72%) patients. Correlation between D-dimer and UAS-7 days showed significant covariance between D-dimer and UAS-7 (p<0.001, r=0.93). Prothrombin time was raised in 55 (55%) patients. Significant correlation was found between PT and UAS-7 (p<0.001, r=0.76). Raised APTT was observed in 61(61%) patients. Correlation between APTT and UAS-7 showed that there was a significant covariance between APTT and UAS-7 (p<0.001, r=0.59).\u0000Conclusions: A significant correlation between markers of coagulation cascade and the disease activity in patients of CSU was seen. These markers can help predict the disease severity and possibly monitor therapeutic response.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"2 11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73482193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232552
Andrea Sierra Franco, Paulina García De León Flores, Paola Scarlett Díaz De Alba, María Jimena Talamante Madrid, Cassandra Espinosa Rodríguez, Renata Monserrat Espejo Nuño
Alopecia areata (AA) is a chronic, immune-mediated disorder resulting in localized hair loss due to targeting hair follicle epithelium. The authors aimed to summarize the existing literature on patients with AA who underwent treatment with Janus kinase inhibitors (JAKis) and discuss the current evidence regarding their efficacy and safety. An extensive scientific literature search was conducted between January 1, 2017, and April 16, 2023, using a recognized medical and scientific database. The extracted data were synthesized and analyzed, focusing on the effect of JAKis in reducing hair loss in adult patients with AA. The evidence suggests that oral JAKis such as tofacitinib, ruxolitinib, and Baricitinib show promise in treating AA regarding both efficacy and safety. The group of drugs JAKis are a good treatment option even in severe clinical conditions of AA, further investigation should be taken to consideration including dosage and treatment duration.
{"title":"Efficacy of Janus kinase inhibitors in adult patients with alopecia areata","authors":"Andrea Sierra Franco, Paulina García De León Flores, Paola Scarlett Díaz De Alba, María Jimena Talamante Madrid, Cassandra Espinosa Rodríguez, Renata Monserrat Espejo Nuño","doi":"10.18203/issn.2455-4529.intjresdermatol20232552","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232552","url":null,"abstract":"Alopecia areata (AA) is a chronic, immune-mediated disorder resulting in localized hair loss due to targeting hair follicle epithelium. The authors aimed to summarize the existing literature on patients with AA who underwent treatment with Janus kinase inhibitors (JAKis) and discuss the current evidence regarding their efficacy and safety. An extensive scientific literature search was conducted between January 1, 2017, and April 16, 2023, using a recognized medical and scientific database. The extracted data were synthesized and analyzed, focusing on the effect of JAKis in reducing hair loss in adult patients with AA. The evidence suggests that oral JAKis such as tofacitinib, ruxolitinib, and Baricitinib show promise in treating AA regarding both efficacy and safety. The group of drugs JAKis are a good treatment option even in severe clinical conditions of AA, further investigation should be taken to consideration including dosage and treatment duration.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84653094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232549
Shruthi Suresh, Namratha C. Manjunath, S. Kumar B C
Methotrexate (MTX) is widely used for the treatment of psoriasis. It has an antiproliferative action by inhibiting dihydrofolate reductase enzyme, therefore interferes with folic acid synthesis. MTX toxicity is rarely reported and the most common cause of it is accidental overdosage by the patient. This is a case report of a 51-year-old male, a known case of psoriasis, who presented with multiple erythematous tender plaques associated with burning sensation. He self-medicated with tablet MTX 5 mg daily for 10 days when the lesions got exacerbated and was found to be leucopenic. On skin biopsy, diagnosis of psoriasis with MTX induced epidermal necrolysis was established. Patient was treated with filgrastim 300 μg which was given subcutaneously 1 day apart. On follow up, lesions subsided and repeat counts were within normal limits. Patients should be explained about the selected treatment regime and discouraged from self-medicating.
{"title":"Rescue therapy in methotrexate toxicity: case report","authors":"Shruthi Suresh, Namratha C. Manjunath, S. Kumar B C","doi":"10.18203/issn.2455-4529.intjresdermatol20232549","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232549","url":null,"abstract":"Methotrexate (MTX) is widely used for the treatment of psoriasis. It has an antiproliferative action by inhibiting dihydrofolate reductase enzyme, therefore interferes with folic acid synthesis. MTX toxicity is rarely reported and the most common cause of it is accidental overdosage by the patient. This is a case report of a 51-year-old male, a known case of psoriasis, who presented with multiple erythematous tender plaques associated with burning sensation. He self-medicated with tablet MTX 5 mg daily for 10 days when the lesions got exacerbated and was found to be leucopenic. On skin biopsy, diagnosis of psoriasis with MTX induced epidermal necrolysis was established. Patient was treated with filgrastim 300 μg which was given subcutaneously 1 day apart. On follow up, lesions subsided and repeat counts were within normal limits. Patients should be explained about the selected treatment regime and discouraged from self-medicating.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"330 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76570109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232541
R. Singh, Deepshikha Parihar, V. Khurana, K. Mahajan, Gulnar Saiyadain
Background: Chronic urticaria is very common distressing dermatoses. CU is caused by autoimmune mechanisms in approximately 30-50% of patients. Repeated injection of autologous whole blood or autologous serum, a form of therapy also known as autohaemotherapy, can be very effective in CAU patients. Aim was to assess the effectiveness of autologous serum therapy in chronic urticaria patients. Methods: All patients with CU attending the dermatology OPD of age >18 years, and urticaria of duration >6 weeks. After autologous serum skin test, autologous serum therapy was administered using autologous serum in a dose of 0.05 ml per kg body weight, injected IM in gluteus muscle weekly for nine weeks in all patients. Parameters of disease activity and severity were recorded at baseline and every week during treatment. End point of study was improvement in chronic modified urticaria total severity score after ninth dose of AST which was recorded at baseline and at 10th week. Results: Mean of MUTSS for ASST positive group and ASST negative group was 13.27±2.050 and 12.04±3.212 respectively which is statistically significant (p=0.043). Mean MUTSS post treatment in ASST positive group was 3.87±4.57 whereas in negative group it was 6.46±4.418 which was statistically significant (p=0.019). Conclusions: 42.3% patients of chronic urticaria were of autoimmune type and approximately half of them responded well to autologous serum therapy. This study found that serum therapy is effective in ASST positive patients with CU.
背景:慢性荨麻疹是一种非常常见的皮肤病。在大约30-50%的患者中，CU是由自身免疫机制引起的。反复注射自体全血或自体血清，一种也被称为自体血液疗法的治疗形式，对CAU患者非常有效。目的评价自体血清治疗慢性荨麻疹的疗效。方法:所有在皮肤科门诊就诊的CU患者，年龄bb ~ 18岁，荨麻疹持续时间bb ~ 6周。自体血清皮试后，采用自体血清治疗，剂量为0.05 ml / kg体重，每周在臀肌注射IM，连续9周。在基线和治疗期间每周记录疾病活动性和严重程度参数。研究终点是在基线和第10周记录第九剂AST后慢性变革性荨麻疹总严重程度评分的改善。结果:阴性组和阳性组的平均MUTSS分别为13.27±2.050和12.04±3.212，差异有统计学意义(p=0.043)。阳性组治疗后平均MUTSS为3.87±4.57，阴性组治疗后平均MUTSS为6.46±4.418，差异有统计学意义(p=0.019)。结论:42.3%的慢性荨麻疹患者为自身免疫性荨麻疹，其中约一半的患者对自体血清治疗反应良好。本研究发现血清治疗对自体皮肤试验阳性的CU患者有效。
{"title":"Autologous serum therapy in chronic urticaria patients","authors":"R. Singh, Deepshikha Parihar, V. Khurana, K. Mahajan, Gulnar Saiyadain","doi":"10.18203/issn.2455-4529.intjresdermatol20232541","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232541","url":null,"abstract":"Background: Chronic urticaria is very common distressing dermatoses. CU is caused by autoimmune mechanisms in approximately 30-50% of patients. Repeated injection of autologous whole blood or autologous serum, a form of therapy also known as autohaemotherapy, can be very effective in CAU patients. Aim was to assess the effectiveness of autologous serum therapy in chronic urticaria patients.\u0000Methods: All patients with CU attending the dermatology OPD of age >18 years, and urticaria of duration >6 weeks. After autologous serum skin test, autologous serum therapy was administered using autologous serum in a dose of 0.05 ml per kg body weight, injected IM in gluteus muscle weekly for nine weeks in all patients. Parameters of disease activity and severity were recorded at baseline and every week during treatment. End point of study was improvement in chronic modified urticaria total severity score after ninth dose of AST which was recorded at baseline and at 10th week.\u0000Results: Mean of MUTSS for ASST positive group and ASST negative group was 13.27±2.050 and 12.04±3.212 respectively which is statistically significant (p=0.043). Mean MUTSS post treatment in ASST positive group was 3.87±4.57 whereas in negative group it was 6.46±4.418 which was statistically significant (p=0.019).\u0000Conclusions: 42.3% patients of chronic urticaria were of autoimmune type and approximately half of them responded well to autologous serum therapy. This study found that serum therapy is effective in ASST positive patients with CU.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79184734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-24DOI: 10.18203/issn.2455-4529.intjresdermatol20232540
Apeksha M. Merja, N. Patel, Maheshvari N. Patel, Megha K. Yadav, Nistha A. Jani
Background: Multi-centered, multi-visit outpatient dermatology studies provide participant-friendly convenience, drawing diverse volunteers while avoiding extended facility stays. However, maintaining a consistent dermatologist for such studies poses challenges, possibly leading to incomplete clinical readings and delaying accurate data collection from predefined datasets. Methods: Led by a Dermatologist, the training aimed to ensure harmony in assessments among trained evaluators when utilizing digital photos to analyze dermatological parameters. It aimed to establish accord between the Dermatologist and Trained Evaluators for inter- and intra-observer evaluations. The training encompassed multiple parameters, such as Draize Scale, Fitzpatrick Skin Type, Glogau Skin Age Classification, IGA (Acne), PGA with Griffith Scale, and PGA for brittle nail signs. Results: The results of the statistical analysis for photographic evaluation inter-evaluator reliability were evaluated. Based on the data, a strong correlation was observed between the Dermatologist's dataset and the Trained Evaluator's dataset. The Pearson chi-square test yielded a p-value of <0.05, indicating significant correlation among the trained evaluators' data compared to the dermatologist's data. All evaluators met the 80% acceptance criteria outlined in the training plan. Both evaluators and dermatologists were deemed suitable for dermatological assessments and photographic evaluations in relevant studies. Conclusions: Theoretical training enabled evaluators to comprehend various dermatological parameters, including Draize Scale, Fitzpatrick Skin Type, Glogau Skin Age Classification, PGA with Griffith Scale, IGA (Acne), and PGA for brittle nail signs. Trained evaluators are now qualified to independently serve as "Dermatologist Validated and Trained Evaluators" in future studies. This approach is applicable for multi-centered, multi-visit dermatological clinical studies.
{"title":"Establishing reliability of dermatologist trained and validated evaluators for assessments of dermatological parameters: a comprehensive overview of concepts and techniques","authors":"Apeksha M. Merja, N. Patel, Maheshvari N. Patel, Megha K. Yadav, Nistha A. Jani","doi":"10.18203/issn.2455-4529.intjresdermatol20232540","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232540","url":null,"abstract":"Background: Multi-centered, multi-visit outpatient dermatology studies provide participant-friendly convenience, drawing diverse volunteers while avoiding extended facility stays. However, maintaining a consistent dermatologist for such studies poses challenges, possibly leading to incomplete clinical readings and delaying accurate data collection from predefined datasets.\u0000Methods: Led by a Dermatologist, the training aimed to ensure harmony in assessments among trained evaluators when utilizing digital photos to analyze dermatological parameters. It aimed to establish accord between the Dermatologist and Trained Evaluators for inter- and intra-observer evaluations. The training encompassed multiple parameters, such as Draize Scale, Fitzpatrick Skin Type, Glogau Skin Age Classification, IGA (Acne), PGA with Griffith Scale, and PGA for brittle nail signs.\u0000Results: The results of the statistical analysis for photographic evaluation inter-evaluator reliability were evaluated. Based on the data, a strong correlation was observed between the Dermatologist's dataset and the Trained Evaluator's dataset. The Pearson chi-square test yielded a p-value of <0.05, indicating significant correlation among the trained evaluators' data compared to the dermatologist's data. All evaluators met the 80% acceptance criteria outlined in the training plan. Both evaluators and dermatologists were deemed suitable for dermatological assessments and photographic evaluations in relevant studies.\u0000Conclusions: Theoretical training enabled evaluators to comprehend various dermatological parameters, including Draize Scale, Fitzpatrick Skin Type, Glogau Skin Age Classification, PGA with Griffith Scale, IGA (Acne), and PGA for brittle nail signs. Trained evaluators are now qualified to independently serve as \"Dermatologist Validated and Trained Evaluators\" in future studies. This approach is applicable for multi-centered, multi-visit dermatological clinical studies.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90870189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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