International Journal of Trichology最新文献

Although hair loss following severe acute respiratory syndrome-coronavirus-2 (COVID-19) infection is common, there are no reported cases of textural changes in COVID-19-associated alopecia. Here, we describe a case of diffuse hair loss followed by distinct changes in hair morphology 1 year after symptomatic COVID-19 infection. Clinical findings were most consistent with anagen effluvium. Robust inflammatory response following COVID-19 infection may contribute to changes in hair texture.

Few dermatologic problems carry as much emotional overtones as the complaint of hair loss, while the best way to alleviate the emotional distress related to the hair loss is to effectively treat it. With the advent of effective pharmacologic agents, the options for managing male pattern hair loss (MPHL) and alopecia-related distress have expanded. Oral finasteride represents a major breakthrough, based on an understanding of the underlying pathophysiology, and observations on the phenotype of the respective genetic defect of type 2 5-alpha reductase. Clinical studies have demonstrated both a high efficacy of treatment and a favorable safety profile establishing the drug as first-line treatment. And yet, after 15 years of successful prescription, the postfinasteride syndrome has emerged. By definition, the condition is characterized by sexual dysfunction, somatic symptoms, and psychological disorders that persist after cessation of treatment. As yet, the condition is not recognized by the medical community. In fact, the concept has emerged from neuroendocrinological research and rodent models, while hair experts have performed investigations into the plausibility of the syndrome based on a comprehensive review of the respective medical literature, and found that persistent sexual side effects were only documented in low-quality studies with strong bias selection, and a significant nocebo effect. In fact, there is more evidence that the condition may represent a psychiatric disorder. In favor of this hypothesis are a striking similarity to Koro with regard to genital symptoms; emergence of the condition with media coverage; a known significant nocebo effect in patients informed about adverse effects of finasteride; high prevalence of personality disorders among men seeking treatment for MPHL; so far no consistent endocrinological or organic abnormalities; and quality of centrality: No matter how unlikely it is that these strange things are happening, the patient accepts them relatively unquestioningly.

Rapunzel syndrome (RS) can have a varied clinical presentation, spanning from being asymptomatic to having a fatal outcome. If left untreated, complications are inevitable. This case highlights an amalgamation of varied presentations of RS with a daughter bezoar acting as a lead point for intussusception, its management, and favorable result. The purpose of this discussion is to throw the focus on the blend of diverse clinical findings and complications of RS with a daughter bezoar; and the importance of early surgical intervention followed by psychological support and psychiatric treatment, as a key to a successful outcome.

Context: Androgenetic alopecia, traction alopecia, and primary cicatricial alopecia can cause distressing scalp hair loss problems affecting a large number of both sexes. Follicular unit extraction (FUE) is one of the best ways to achieve improving conditions of those cases.

Aims: The aim of this study was to evaluate the FUE technique as a method for permanent hair restoration problems.

Settings and design: Channels for the grafts were created through pieces of hand-cut razor blades.

Subjects and methods: Twenty patients suffering from alopecia were eligible to participate in the study. They were subjected to FUE.

Results: On comparing different types of alopecia, we found that cicatricial alopecia was significantly more common among younger patients, unlike traction and traction types which were relatively more common among older patients (P = 0.043). There was no significant difference between alopecia types concerning the duration of operation. However, the number of implants was significantly higher among patients with androgenic alopecia when compared with cicatricial and traction subtypes (P < 0.001). Concerning patients' satisfaction, we found that there was no significant difference between alopecia types concerning patients, observers, or doctor satisfaction with an overall satisfaction rate ranging between 3.67 and 4.

Conclusions: Till now, there is no specific algorithm for treating patients with hair loss. However, there is a general preference of patients toward surgical options being less time-consuming and achieve better results. Whatever the cause is FUE showed good results concerning postpatients satisfaction concerning their appearance and visual age.

Background: Correct hair wash frequency and the right product are essential for scalp and hair care. Women wearing hijab are becoming more common. However, no consensus has been published regarding the correct frequency of hair washing, especially for women wearing hijab. Research is needed to compare the influence of different hair wash frequencies on scalp health. The aim of this study is to assess the correlation between hair wash frequency with scalp transepidermal water loss (TEWL) and hydration in women wearing hijab.

Methods: Sixty healthy women in reproductive age were allocated into 30 subjects in Group A (frequent hair wash, every 1-2 days) and 30 subjects in Group B (infrequent hair wash, every 3-5 days). Measurements of scalp skin TEWL and hydration were performed on baseline, day-14, and day-28.

Results: The day-28 median value of scalp skin TEWL was 20.87 g/m²/h in Group A and 17.67 g/m²/h in Group B (P < 0.01). The day-28 median value of scalp skin hydration was 11.48 AU in Group A and 12.77 AU in Group B (P > 0.05).

Conclusions: Frequent hair wash may significantly increase scalp TEWL score in women wearing hijab. However, there is no correlation between hair wash frequency and scalp hydration in women wearing hijab.

Context: Cell expansion for clinical cell culture often involves the use of fetal bovine serum (FBS). Recently, human platelet-rich plasma (hPRP) was suggested as an FBS substitute, to minimize the risk of transmission of various pathogens and immunogenic reactions. However, whether hPRP can replace FBS for the expansion of human dermal papilla cells (hDPCs) remains controversial.

Aims: To assess the potential of hPRP as a substitute for FBS in hDPC expansion, we investigated the effect of hPRP on hDPC expansion.

Materials and methods: We first standardized the method of hPRP preparation, and then investigated the effect of hPRP on the proliferation and hair-inductive capacity of cultured hDPCs by comparing with that of FBS. To prepare hPRP, we used heparin as the anticoagulant, with purification by single-spin centrifugation, and freeze-thaw hPRP activation.

Results: Compared with an FBS-supplemented medium, hPRP supplementation significantly shortened the population doubling time of cultured hDPCs, and increased the ratio of bromodeoxyuridine-labeled proliferating cells. Expression of the alkaline phosphatase gene related to hair-inductive capacity was enhanced in hDPCs cultured in an hPRP-supplemented medium. In vivo hair follicle reconstitution assay confirmed that hPRP supplementation enhanced the hair-inductive capacity of hDPCs compared with an FBS-supplemented medium, based on the increased number of regenerated hair follicles and their maturity. Overall, compared with FBS, hPRP enhanced the proliferation of hDPCs, while preserving their hair-inductive capacity.

Conclusions: The results show that hPRP can be used to replace FBS for hDPC expansion. These findings inform the development of an effective clinically applicable hair regeneration therapy.