International Journal of Trichology最新文献

Several reports more so from western countries present recovery for alopecia areata (AA) with tofacitinib. In this report, we present the case of a young adult male diagnosed with resistant AA with failed treatment to oral as well topical steroids, minoxidil, and oral troxasalen. He was treated with tofacitinib 5 mg twice a day along with biotin supplement. Hair regrowth was observed at 1 month. After 3 months, nearly more than 90% hair regrowth was observed. No associated side effects were noted.

Transient rectangular alopecia after endovascular embolization (TRAEE) is considered a specific form of radiodermatitis that is probably underreported in the literature. We present a case series of four patients from our hospital describing dermoscopic and histopathologic findings. Dermoscopic findings overlap with those of alopecia areata; therefore, TRAAE may be misdiagnosed without a precise history. Histopathology analysis of one of our cases showed different characteristics from the only report in the literature (high proportion of follicles in telogen phase). Initial reports considered that total radiation doses between 3 and 5 Gy produced TRAEE, whereas doses higher than 7Gy could trigger permanent alopecia. However, one of our patients exposed to a total dose of 7.6 Gy had complete hair regrowth.

Aim: The aim of this study is to identify a new method to measure oil penetration into hair, compare penetration ability of two types of oil: Type 3 hair oil and coconut oil into the hair shaft and explore its correlation to a physical property of hair, tensile strength.

Materials and methods: The study utilizes the measurements of two parameters, thickness, and cohesive force to define penetration of oil. The hypothesis was that an increase in hair fiber thickness along with reduction in cohesive force would indicate higher penetration of oil into the hair strand. The tensile strength of hair was then determined by measuring the behavior of treated hair strands while an axial stretching load was applied.

Results: In experiment of hair thickness measurement, there was a significant increase in the hair fiber thickness post oil application in both the test oils as compared to baseline (untreated control). However, this increase was higher in hair swatches treated with Type 3 hair oil. For cohesive force measurement, significantly lower force was required for hair swatches treated with Type 3 hair oil when compared to coconut oil. For tensile strength, both test oils exhibited increase versus baseline but increase in tensile strength was significantly more with type 3 hair oil when compared to coconut oil.

Conclusions: The present study shows that conjoint assessment of hair thickness and cohesive force post oil application can be a suitable method to indicate the extent of oil penetration into the hair. Overall, the study indicated the positive influence of oil penetration on hair strength.

Background: Oral isotretinoin has been used to treat acne for decades. Although the side effects of isotretinoin are mostly predictable, one less common side effect of isotretinoin use is hair loss, typically telogen effluvium.

Objective: This study is a retrospective report on the development of alopecia in patients on isotretinoin therapy.

Methods: To characterize these patients, they were further compared to other patients in the same time period who were prescribed isotretinoin and did not experience hair loss.

Results: Of 6330 patients with hair loss, 48 had been prescribed isotretinoin at some time between 2013 and 2018. Of these 48 patients, hair loss occurred concurrently or within two years after taking isotretinoin in 19 patients. When compared to controls, patients who experienced hair loss from isotretinoin were older, had greater cumulative isotretinoin doses, and had longer durations of treatment.

Conclusion: Although the exact mechanism of how retinoids affect hair loss is still unclear, our findings suggest dosage or duration of usage may be associated. This information may be useful in counseling patients who may be concerned about hair loss when considering isotretinoin treatment.