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Pradhan Mantri TB Mukt Bharat Abhiyaan-A step towards the elimination of the oldest known infectious disease Pradhan Mantri TB Mukt Bharat abhiyaan -消除已知最古老的传染病的一步
Pub Date : 2022-10-15 DOI: 10.18231/j.ijirm.2022.024
S. Yadav, G. Rawal, Surinder Pal
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引用次数: 0
Nebulization as the mode to administer therapeutic bacteriophages to resolve Acinetobacter pneumonia in rabbits 以雾化方式给药治疗性噬菌体治疗兔不动杆菌肺炎
Pub Date : 2022-10-15 DOI: 10.18231/j.ijirm.2022.029
Vinodkumar C.S, Ananya V Swamy, Shreshta Shamanur, Arpitha Venkatareddy, V. L. Jayasimha, S. Reddy, Susan Jyothica Dsouza, S. H
Multidrug-resistant strains of , a significant hospital pathogen, have developed resistance to virtually all available antibiotics. Carbapenems antibiotics are among the most commonly used antibiotics against Acinetobacter infections, but they can be rendered ineffective by the metallo-beta-lactamase enzyme. In this study, bacteriophage isolated against producing was evaluated for its therapeutic potential in the rabbit pneumonia model.was isolated from the sputum and was speciated as per the standard microbiological techniques. Bacteriophage specific for producing from the sewage water. Pneumonia was introduced in the rabbits as per Esposito Pennington method and efficacy of the bacteriophage in resolving pneumonia was evaluated. For in-vivo experiments, five groups of rabbits were used including infection-free, phage control, bacteria-infected control, and the other two groups infected with and treated either with an antibiotic, colistin (2.5 mg/kg, twice a day intraperitoneally) or Acinetobacter phage (3×10 PFU/mL, given once through nebulizer). The experimental animals were monitored for 72 hours for mortality, and the surviving rabbits were killed for bacteriological and histopathological analysis In the infected group, pneumonia was developed within 48 hours, and 6/10 animals were dead after 72 hours. All the animals in the antibiotic group survived but showed signs of pneumonia, and there was up to 4 log CFU/g±0.24 reduction in the bacterial count. In phage treated group, all the animals survived at the end of 72 hours and all the animals were healthy with no signs of pneumonia. The experiment showed new insights into the application of bacteriophage through nebulization, a non-invasive method of phage delivery to rescue rabbits from pneumonia caused by -producing .
多药耐药菌株是一种重要的医院病原体,已对几乎所有可用的抗生素产生耐药性。碳青霉烯类抗生素是抗不动杆菌感染最常用的抗生素之一,但它们可能被金属- β -内酰胺酶失效。在本研究中,对分离的抗产噬菌体在兔肺炎模型中的治疗潜力进行了评价。从痰中分离得到,并按标准微生物学技术进行了物种划分。从污水中产生的特异性噬菌体。采用埃斯波西托·彭宁顿法引入家兔肺炎,评价噬菌体治疗肺炎的疗效。体内实验采用无感染、噬菌体对照组、细菌感染对照组五组家兔,另外两组家兔分别感染抗生素粘菌素(2.5 mg/kg,每天2次腹腔注射)或不动杆菌噬菌体(3×10 PFU/mL, 1次通过雾化器给药)。对实验动物进行72小时的死亡监测,将存活的家兔处死进行细菌学和组织病理学分析。感染组在48小时内出现肺炎,72小时后6/10只动物死亡。抗生素组的所有动物都存活了下来,但出现了肺炎的迹象,细菌数量减少了4 log CFU/g±0.24。在噬菌体治疗组,所有动物在72小时结束时均存活,所有动物健康,无肺炎症状。本实验为噬菌体雾化给药,一种非侵入性的噬菌体给药方法,在治疗产-所致肺炎家兔中的应用提供了新的见解。
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引用次数: 0
Study of correlation of red cell distribution width with acute exacerbation of chronic obstructive pulmonary disease 慢性阻塞性肺疾病急性加重期红细胞分布宽度的相关性研究
Pub Date : 2022-10-15 DOI: 10.18231/j.ijirm.2022.026
Ravi Gaur, V. Tundwal, R. Gaur, Mohit Gaur, J. Khatri
Acute exacerbation of COPD is one of the most common disease in patients with infections, having frequent hospitalization. The aim of this study is to find whether there is any relationship between RDW with mortality in AECOPD. The hospital based case control Study is was conduct on hospitalized 50 patient with primary and final diagnosis of AECOPD and 50 patient of stable period of COPD. Socio-demographic variable in both groups were comparable. BMI was significantly lower in AECOPD patients. The mean PACK/YR in AECOPD group was 24.44±6.23 and in Stable COPD was 20.66±8.21. Mean admission per year were significantly higher in AECOPD patients (1.88±0.80 per year) as compare to stable COPD patients (0.80±0.67 per year). Mean FEV1 % was significantly lower in AECOPD patients (43.87±14.26) as compare to stable COPD patients (48.12±20.18). Mean RDW significantly higher in AECOPD (17.60±5.70%) as compare to stable COPD patients (13.80±3.33%). The difference in both groups was found statistically significant. MCV was significantly lower in AECOPD (82.04±1.49) as compare to stable COPD patients (86.50±1.87). The difference in both groups was found statistically significant. RDW was significantly higher in those patient who were died (19.50±0.70%) as compare to survived patients (17.52±5.61%). The difference in both groups was found statistically significant. 4.00% hospital mortality in AECOPD group. We have concluded that the mean red cell distribution width on the day of presenting the illness was significantly higher in AECOPD as compare to stable COPD. Those patients who had a high red cell distribution width during admission were associated with poor prognosis.
慢性阻塞性肺病急性加重是感染患者最常见的疾病之一,经常住院治疗。本研究的目的是发现RDW与AECOPD死亡率之间是否存在关系。以医院为基础的病例对照研究对住院的50例初、终诊断为AECOPD的患者和50例稳定期COPD患者进行研究。两组的社会人口统计学变量具有可比性。AECOPD患者的BMI显著降低。AECOPD组平均PACK/YR为24.44±6.23,稳定期为20.66±8.21。AECOPD患者的年平均入院率(1.88±0.80 /年)明显高于稳定型COPD患者(0.80±0.67 /年)。AECOPD患者的平均FEV1 %(43.87±14.26)明显低于稳定期COPD患者(48.12±20.18)。AECOPD患者的平均RDW(17.60±5.70%)明显高于稳定期COPD患者(13.80±3.33%)。两组的差异有统计学意义。AECOPD患者的MCV(82.04±1.49)明显低于稳定期COPD患者(86.50±1.87)。两组的差异有统计学意义。死亡患者的RDW(19.50±0.70%)明显高于存活患者(17.52±5.61%)。两组的差异有统计学意义。AECOPD组住院死亡率4.00%。我们得出结论,AECOPD患者在发病当天的平均红细胞分布宽度明显高于稳定型COPD患者。入院时红细胞分布宽度高的患者预后较差。
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引用次数: 0
COVID-19 lockdown – Health and nutritional status of the general public in Lucknow COVID-19封锁-勒克瑙普通公众的健康和营养状况
Pub Date : 2022-10-15 DOI: 10.18231/j.ijirm.2022.025
N. Kumari, S. Shukla, D. Jemima, Anjali Singh, S. Kant
When the Indian Government announced a nationwide lockdown on March 24, 2020, the lives of Indian people were changed immediately as people started shifting to a different way of living. Therefore, to assess the impact and effect of the nationwide lockdown on the health status and lifestyle habits of the general population, this study was conducted on a sample size of 70 people based in Lucknow. The participants were administered a questionnaire with questions on their diet, lifestyle habits and health. Data was then analysed using Microsoft Excel. The results showed significant changes in the daily routine and habits of people during the lockdown. Lifestyle changes such as increase in snacking, smoking and consuming alcohol could lead to future problems such as increase in the development of non-communicable diseases.
2020年3月24日,印度政府宣布在全国范围内实施封锁,印度人民的生活立即发生了变化,人们开始转向不同的生活方式。因此,为了评估全国范围内的封锁对一般人群的健康状况和生活习惯的影响和影响,本研究以勒克瑙的70人为样本进行了研究。参与者被要求填写一份关于他们的饮食、生活习惯和健康状况的问卷。然后使用Microsoft Excel对数据进行分析。结果显示,在封锁期间,人们的日常生活和习惯发生了重大变化。生活方式的改变,如零食、吸烟和饮酒的增加,可能导致未来的问题,如非传染性疾病的发展增加。
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引用次数: 0
Lung abscess with metastatic brain abscess- A case report 肺脓肿合并转移性脑脓肿1例
Pub Date : 2022-10-15 DOI: 10.18231/j.ijirm.2022.031
V. Govindaraj, B. Kumar, Dharm Prakash Dwivedi, P. Upadhya
Brain abscess can result from spread of infection from contiguous sites or from distant hematogenous spread. Hematogenous spread from a distant site as from the lungs is more common with cyanotic congenital heart disease and in patients with infective endocarditis. We report a case of hematogenous spread of brain abscess from lung in a patient who had no concurrent heart disease. Klebsiella pneumonia was isolated both from brain abscess and from lung abscess. A fifty years old lady with uncontrolled sugars presented with cough with expectoration and fever. Chest X ray showed cavity with fluid level on the right side and sputum culture showed Klebsiella pneumoniae. She was treated with sensitive antibiotics. During in hospital stay she developed headache and blurring of vision. CT brain showed a right parietal lobe abscess. She underwent decompression procedure and abscess from brain was drained which also revealed growth of Klebsiella pneumoniae. Her echo was normal. She was treated with sensitive antibiotics and had clinical improvement. While treating a case of lung abscess, clinicians should be aware of the possibility of metastatic spread and a high index of suspicion and a radiological imaging leads to early diagnosis and treatment.
脑脓肿可由感染从邻近部位扩散或远端血液扩散引起。远端(如肺)血源性扩散在紫绀型先天性心脏病和感染性心内膜炎患者中更为常见。我们报告一例脑脓肿血行扩散从肺在病人谁没有并发心脏疾病。肺炎克雷伯菌分别从脑脓肿和肺脓肿中分离出来。一位五十岁的妇女,血糖控制不佳,表现为咳嗽、咳痰和发烧。胸部X线示右侧空腔液面,痰培养示肺炎克雷伯菌。她接受了敏感的抗生素治疗。住院期间,她出现头痛和视力模糊的症状。CT显示右侧顶叶脓肿。她接受了减压手术和脑脓肿引流,也发现肺炎克雷伯菌的生长。她的回声正常。患者经敏感抗生素治疗,临床好转。在治疗肺脓肿病例时,临床医生应意识到转移扩散的可能性,高度怀疑和影像学检查有助于早期诊断和治疗。
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引用次数: 0
Pyoderma gangrenosum in tuberculosis: A rare association 结核性坏疽脓皮病:罕见的关联
Pub Date : 2022-10-15 DOI: 10.18231/j.ijirm.2022.032
Sonali Parida, Poulomi Sen
Pyoderma gangrenosum is an uncommon dermatological condition with varied etiology. Mostly it is associated with inflammatory conditions and malignancies as well. Tuberculosis being a chronic infective process can also be associated with pyoderma gangrenosum although rare. We report a case of tuberculous pleural effusion presenting with pyoderma gangrenosum during the course of treatment and its subsequent management while continuing the treatment for tuberculosis.
坏疽性脓皮病是一种罕见的皮肤病,病因多样。它大多与炎症和恶性肿瘤有关。结核病是一种慢性感染过程,也可与坏疽性脓皮病有关,尽管罕见。我们报告一例结核性胸腔积液在治疗过程中表现为坏疽性脓皮病及其后续管理,同时继续治疗结核病。
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引用次数: 0
Outcomes of community acquired pneumonia in a tertiary hospital 某三级医院社区获得性肺炎的结局分析
Pub Date : 2022-10-15 DOI: 10.18231/j.ijirm.2022.030
Janso Kollanur, R. Pulikal, A. R, D. Chelangara, Krishna Ev
Despite the advances in healthcare setup, Community Acquired pneumonia still continues to be one of the major causes of morbidity and mortality among the hospitalised, especially the elderly population. Knowledge about the distribution of the disease, susceptible population, risk factors, mortality and morbidity outcomes makes it easy for the effective management of the affected individuals. Even though we have enough data on worldwide distribution and outcome of CAP, similar studies in Indian setup are few. Considering the fact that the change in environment, population characteristics and difference in clinical practices can hugely influence the outcome of CAP, it was found necessary to conduct this study.: To understand the demographic profile of patients, to identify the main symptoms and risk factors and to find out the outcome of patients admitted with CAP in a tertiary health care centre in Thrissur. Retrospective study by collecting the details of patients hospitalized with CAP in the past one year by going through their medical records. The incidence of CAP was found to be steadily increasing with age, more in males with productive cough being the most common symptom. While in majority of cases no organisms were isolated, the ones which had an identified causative organism were mainly bacterial. Maximum cases occurred in monsoon season and the mortality rate was 2%.
尽管在卫生保健方面取得了进展,但社区获得性肺炎仍然是住院患者,特别是老年人发病和死亡的主要原因之一。对疾病分布、易感人群、风险因素、死亡率和发病率结果的了解,有助于对受影响的个人进行有效管理。尽管我们有足够的关于全球范围内CAP分布和结果的数据,但在印度的类似研究很少。考虑到环境的变化、人群特征和临床实践的差异会极大地影响CAP的结果,因此有必要进行本研究。了解患者的人口特征,确定主要症状和风险因素,并查明在Thrissur三级保健中心接受CAP治疗的患者的结果。回顾性研究,通过查阅病历资料,收集近一年内CAP住院患者的详细资料。发现CAP的发病率随着年龄的增长而稳步增加,在男性中以生产性咳嗽为最常见的症状。虽然大多数病例未分离出微生物,但鉴定出病原生物的主要是细菌。最多病例发生在季风季节,死亡率为2%。
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引用次数: 1
Disease X-An inevitable threat to mankind x病是对人类不可避免的威胁
Pub Date : 2022-07-15 DOI: 10.18231/j.ijirm.2022.013
S. Yadav
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引用次数: 0
Monkeypox in the pandemic of coronavirus disease 2019 2019冠状病毒病大流行中的猴痘
Pub Date : 2022-07-15 DOI: 10.18231/j.ijirm.2022.012
S. Yadav
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引用次数: 0
COVID-19 associated mucormycosis with frontal bone osteomyelitis 2019冠状病毒病相关毛霉病伴额骨骨髓炎
Pub Date : 2022-07-15 DOI: 10.18231/j.ijirm.2022.020
N. Gupta, R. Gupta, Rajiv Goel, D. Gautam, V. Singh
During the coronavirus disease 2019 (COVID-19) pandemic, increasing cases of COVID-19 associated mucormycosis (CAM) have been reported. This may be attributed directly to the COVID-19 infection or the associated unrecognised uncontrolled hyperglycaemia compounded by the use of COVID-19 treatment strategies such as steroids and IL-6 inhibitors. As mucormycosis is one of the most rapidly progressing fungal infection, an early diagnosis and early appropriate management are of prime importance in reducing mortality. Rhino-orbital-cerebral and pulmonary mucormycosis have been the most common presentations of CAM. Osteomyelitis in mucormycosis is very rare, although a few cases of maxillary bone involvement have been reported with CAM. We report a very rare and challenging case of extensive frontal bone osteomyelitis in a patient with CAM with frontal sinusitis and without orbital or maxillary bone involvement.
在2019冠状病毒病(COVID-19)大流行期间,报告的COVID-19相关毛霉菌病(CAM)病例不断增加。这可能直接归因于COVID-19感染或相关的未被识别的未控制的高血糖,加上使用类固醇和IL-6抑制剂等COVID-19治疗策略。由于毛霉病是进展最迅速的真菌感染之一,早期诊断和早期适当治疗对于降低死亡率至关重要。鼻-眶-脑和肺毛霉菌病是CAM最常见的表现。毛霉病引起的骨髓炎是非常罕见的,尽管有少数上颌骨受累的病例报道了CAM。我们报告一个非常罕见和具有挑战性的病例,广泛的额骨骨髓炎患者与额窦炎和没有眶或上颌骨受累。
{"title":"COVID-19 associated mucormycosis with frontal bone osteomyelitis","authors":"N. Gupta, R. Gupta, Rajiv Goel, D. Gautam, V. Singh","doi":"10.18231/j.ijirm.2022.020","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.020","url":null,"abstract":"During the coronavirus disease 2019 (COVID-19) pandemic, increasing cases of COVID-19 associated mucormycosis (CAM) have been reported. This may be attributed directly to the COVID-19 infection or the associated unrecognised uncontrolled hyperglycaemia compounded by the use of COVID-19 treatment strategies such as steroids and IL-6 inhibitors. As mucormycosis is one of the most rapidly progressing fungal infection, an early diagnosis and early appropriate management are of prime importance in reducing mortality. Rhino-orbital-cerebral and pulmonary mucormycosis have been the most common presentations of CAM. Osteomyelitis in mucormycosis is very rare, although a few cases of maxillary bone involvement have been reported with CAM. We report a very rare and challenging case of extensive frontal bone osteomyelitis in a patient with CAM with frontal sinusitis and without orbital or maxillary bone involvement.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83419896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
IP Indian Journal of Immunology and Respiratory Medicine
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