{"title":"[The physiological mechanisms of aging and research on age-related mortality].","authors":"V B Mamaev","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"634-7"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12623056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The trigger of the aging process--in the nucleus or the mitochondria?].","authors":"A Ia Litoshenko","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"645-8"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12623063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S V Kharchenko, V S Pronin, A V Aleksandrov, G A Korneeva, A P Chesnokova
A bioenergetic conception of insulin-independent diabetes mellitus (IIDM) is put forward. Molecular mechanisms of carbohydrate and fat metabolism are discussed which result in a vicious regulatory cycle to provoke a transition to stable pathology. Previously unknown role of human saliva in oral cavity in this regulatory cycle is revealed. New diagnostic tests are developed on the basis of the conception on IIDM pathogenesis. The results of clinical trials are presented which have been obtained during population screening.
{"title":"[New approaches to the diagnosis of carbohydrate metabolic disorders].","authors":"S V Kharchenko, V S Pronin, A V Aleksandrov, G A Korneeva, A P Chesnokova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A bioenergetic conception of insulin-independent diabetes mellitus (IIDM) is put forward. Molecular mechanisms of carbohydrate and fat metabolism are discussed which result in a vicious regulatory cycle to provoke a transition to stable pathology. Previously unknown role of human saliva in oral cavity in this regulatory cycle is revealed. New diagnostic tests are developed on the basis of the conception on IIDM pathogenesis. The results of clinical trials are presented which have been obtained during population screening.</p>","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"575-81"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12455528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Members of MB1 family repeats are revealed in genomes of many mammals (cow, rabbit, opossum, horse, ...). The MB1 repeats from cow and rabbit genomes are mirror-reflected about the SINE families repeats from cow and rabbit genomes. The life time of MB1 repeats are no less than 100 million years. Classification of MB1 repeats from human genome using the information similarity was performed. This classification has revealed two subfamily MB1 repeats in human genome. Possible processes of creation of MB1 family repeats common for many mammals are discussed.
{"title":"[The MB1 family of repeats in clones from the genomes of mammals].","authors":"E V Korotkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Members of MB1 family repeats are revealed in genomes of many mammals (cow, rabbit, opossum, horse, ...). The MB1 repeats from cow and rabbit genomes are mirror-reflected about the SINE families repeats from cow and rabbit genomes. The life time of MB1 repeats are no less than 100 million years. Classification of MB1 repeats from human genome using the information similarity was performed. This classification has revealed two subfamily MB1 repeats in human genome. Possible processes of creation of MB1 family repeats common for many mammals are discussed.</p>","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"546-57"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12623052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A L Lobashevskiĭ, N V Davydova, V M Uriniuk, N N Sukhareva
Effect of water-soluble (polypeptides) fraction (PF) of Crithidia oncopelti on the chemiluminescence of human blood cells and murine splenocytes was studied. The study has shown that PF possessed a capacity to inhibit oxygen-dependent killer system of polymorphonuclear leucocytes in dose-dependent manner. This effect was of a complex nature. The inhibitory effect of PF was demonstrated also in respect to murine mononuclear phagocytes and splenocytes. It was suggested that, in this case, the suppressor effect was related with the influence on membranous cytokines.
{"title":"[The suppression of the chemiluminescence of mammalian cells by the metabolites of Crithidia oncopelti].","authors":"A L Lobashevskiĭ, N V Davydova, V M Uriniuk, N N Sukhareva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Effect of water-soluble (polypeptides) fraction (PF) of Crithidia oncopelti on the chemiluminescence of human blood cells and murine splenocytes was studied. The study has shown that PF possessed a capacity to inhibit oxygen-dependent killer system of polymorphonuclear leucocytes in dose-dependent manner. This effect was of a complex nature. The inhibitory effect of PF was demonstrated also in respect to murine mononuclear phagocytes and splenocytes. It was suggested that, in this case, the suppressor effect was related with the influence on membranous cytokines.</p>","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"565-74"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12623053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Aging and the immortalization of animal cells: the key role of nuclear proto-oncogenes].","authors":"Iu M Romanchikov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"643-5"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12623061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The mitochondrial theory of aging].","authors":"A I Zotin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"650-1"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12623004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T V Krutova, S B Chernikova, A A Konradov, E B Burlakova
The change of stationary cell population (murine spleen) following an exposure to low doses of methylnitrosourea (10(-11)-10(-5) g/kg of mouse weight) was investigated and modelled mathematically. The suggested model is based on the idea that the effect of cytotoxic agent in low doses has nondestructive "signal" character, changing dynamic balance between cells in proliferating and quiescent compartments.
{"title":"[The action of low doses of nitrosomethylurea on a stationary cell population. An experiment and modelling].","authors":"T V Krutova, S B Chernikova, A A Konradov, E B Burlakova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The change of stationary cell population (murine spleen) following an exposure to low doses of methylnitrosourea (10(-11)-10(-5) g/kg of mouse weight) was investigated and modelled mathematically. The suggested model is based on the idea that the effect of cytotoxic agent in low doses has nondestructive \"signal\" character, changing dynamic balance between cells in proliferating and quiescent compartments.</p>","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 4","pages":"511-8"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12623050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Based on statistical peculiarities of the existence of two-leveled thermodynamic systems, it was shown that the probability of existence for warm-blooded organisms is determined by body temperature, energy of metabolism, and thermodynamic potentials of critical increase and decrease in the body temperature. It was established that the dynamics of human death rate from the birth to extreme old age is conditioned by age-related changes in the energy of metabolism. It was shown that maintenance of the metabolic level in aging is very important for the life prolongation.
{"title":"[Body temperature, internal energy and the probability of the existence of warm-blooded animals and man].","authors":"V A Shestiperov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Based on statistical peculiarities of the existence of two-leveled thermodynamic systems, it was shown that the probability of existence for warm-blooded organisms is determined by body temperature, energy of metabolism, and thermodynamic potentials of critical increase and decrease in the body temperature. It was established that the dynamics of human death rate from the birth to extreme old age is conditioned by age-related changes in the energy of metabolism. It was shown that maintenance of the metabolic level in aging is very important for the life prolongation.</p>","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 2","pages":"262-9"},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12601508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In order to enhance the outcome of high-quality reverse transcriptase enzyme, an efficient biotechnology was developed of accumulating and isolating the avian myeloblastosis virus (AMV) in high titres from blood plasma of leukosis-free chickens. When commercial chickens are infected in most sensitive one-day age, the virus titre does not exceed the value of 10(12) particles per 1 ml of plasma. We used 3-4-day old leukosis free chickens and achieved a stable average titre of the virus of 5.10(12) particles/ml due to adaptation of the virus to such chickens and their selection for a high sensitivity to AMV.
{"title":"[The technology for isolating the avian myeloblastosis virus in high titers from leukosis-free chicks].","authors":"E V Rat'kin, E G Piker, E V Zlotina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to enhance the outcome of high-quality reverse transcriptase enzyme, an efficient biotechnology was developed of accumulating and isolating the avian myeloblastosis virus (AMV) in high titres from blood plasma of leukosis-free chickens. When commercial chickens are infected in most sensitive one-day age, the virus titre does not exceed the value of 10(12) particles per 1 ml of plasma. We used 3-4-day old leukosis free chickens and achieved a stable average titre of the virus of 5.10(12) particles/ml due to adaptation of the virus to such chickens and their selection for a high sensitivity to AMV.</p>","PeriodicalId":14529,"journal":{"name":"Izvestiia Akademii nauk SSSR. Seriia biologicheskaia","volume":" 2","pages":"303-9"},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12601456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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