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Classifying Invention Objectives of Electric Vehicle Chargers through Natural Language Processing and Machine Learning 通过自然语言处理和机器学习对电动汽车充电器的发明目标进行分类
IF 3.4 Q1 Engineering Pub Date : 2023-11-19 DOI: 10.3390/inventions8060149
R. Bridgelall
The gradual adoption of electric vehicles (EVs) globally serves as a crucial move toward addressing global decarbonization goals for sustainable development. However, the lack of cost-effective, power-efficient, and safe chargers for EV batteries hampers adoption. Understanding the research needs and identifying the gaps in EV charger innovation informs investments and research to address development challenges. This study developed a unique text mining workflow to classify themes in EV charger technology and product development by analyzing U.S. patent award summaries. The text mining workflow combined the techniques of data extraction, data cleaning, natural language processing (NLP), statistical analysis, and unsupervised machine learning (ML) to extract unique themes and to visualize their relationships. There was a 47.7% increase in the number of EV charger patents issued in 2022 relative to that in 2018. The top four themes were charging station management, power transfer efficiency, on-board charger design, and temperature management. More than half (53.8%) of the EV charger patents issued over the five-year period from 2018 to 2022 addressed problems within those four themes. Patents that addressed wireless charging, fast charging, and fleet charging accounted for less than 10% each of the EV charger patents issued. This suggests that the industry is still at the frontier of addressing those problems. This study further presents examples of the specific EV charger problems addressed within each theme. The findings can inform investment decisions and policymaking to focus on R&D resources that will advance the state of the art and spur EV adoption.
电动汽车(EV)在全球范围内的逐步普及是实现全球可持续发展脱碳目标的关键一步。然而,电动汽车电池缺乏高性价比、高能效和安全的充电器,阻碍了电动汽车的普及。了解电动汽车充电器创新方面的研究需求并找出差距,可为投资和研究提供信息,从而应对发展挑战。本研究开发了一种独特的文本挖掘工作流程,通过分析美国专利奖摘要,对电动汽车充电器技术和产品开发的主题进行分类。文本挖掘工作流程结合了数据提取、数据清理、自然语言处理 (NLP)、统计分析和无监督机器学习 (ML) 等技术,以提取独特的主题并将其关系可视化。与2018年相比,2022年发布的电动汽车充电器专利数量增加了47.7%。排在前四位的主题分别是充电站管理、电力传输效率、车载充电器设计和温度管理。从 2018 年到 2022 年的五年间,一半以上(53.8%)的电动汽车充电器专利都涉及这四个主题中的问题。涉及无线充电、快速充电和车队充电的专利在已发布的电动汽车充电器专利中各占不到 10%。这表明该行业仍处于解决这些问题的前沿。本研究进一步举例说明了每个主题中涉及的具体电动汽车充电器问题。研究结果可为投资决策和政策制定提供参考,以便集中研发资源,推动技术发展,促进电动汽车的采用。
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引用次数: 0
Flow Instability Control in a Model Swirl-Stabilized Combustor with Central Jet Injection 带中央喷射的模型漩涡稳定燃烧器中的流动不稳定性控制
IF 3.4 Q1 Engineering Pub Date : 2023-11-17 DOI: 10.3390/inventions8060148
Alexey Savitskii, D. Sharaborin, L. Chikishev, V. Dulin
Swirling flows often occur in nature and industrial applications. With an increase in swirl intensity, such rotating flows are known to become unstable and undergo a sudden breakdown of the vortex core, resulting in unsteady flow dynamics with intensive pressure fluctuations. In particular, swirling flows are organized in combustion chambers to stabilize the flame around the central recirculation zone, formed due to the vortex core breakdown. However, the impact of large-scale vortex structures, including the precessing vortex core and secondary helical vortices, on unsteady combustion regimes is still unclear. The present paper demonstrates experimentally that for the swirling flow of a model swirl combustor, the injection of a central jet may be used to alter the configuration of coherent flow structures, including helical vortices. In particular, the asymmetric hydrodynamics mode, associated with the precessing vortex core, is suppressed, whereas the symmetrical one becomes dominant. This effect demonstrates the importance of central jet injection to control the dominant mode of flow instability for the design of swirl combustors.
漩涡流经常出现在自然界和工业应用中。众所周知,随着漩涡强度的增加,这种旋转流会变得不稳定,漩涡核心会突然破裂,从而导致不稳定的流动动态和剧烈的压力波动。特别是,燃烧室中的漩涡流是为了稳定中心再循环区周围的火焰而形成的,中心再循环区是由于涡核破裂而形成的。然而,大尺度漩涡结构(包括前冲漩涡核心和次级螺旋漩涡)对非稳态燃烧机制的影响仍不清楚。本文通过实验证明,对于模型漩涡燃烧器的漩涡流,中心射流的喷射可用于改变相干流结构(包括螺旋漩涡)的配置。特别是,与前冲漩涡核心相关的非对称流体力学模式被抑制,而对称模式成为主导。这种效应表明,中心喷射对于控制漩涡燃烧器设计中的主要流动不稳定模式非常重要。
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引用次数: 0
Mini-Kilns for Charcoal-Making: An Eco-Friendly Solution for Small-Scale Production of Charcoal and Wood Vinegar 用于制炭的迷你窑炉:小规模生产木炭和木醋的环保解决方案
IF 3.4 Q1 Engineering Pub Date : 2023-11-17 DOI: 10.3390/inventions8060146
Felipe Bento de Albuquerque, Rafael Rodolfo de Melo, Alexandre Santos Pimenta, Edgley Alves de Oliveira Paula, M. V. Scatolino, Fernando Rusch
Charcoal is one of the most essential energy sources in the world and is used mainly for domestic and industrial purposes. Brazilian charcoal production occurs in rudimentary masonry kilns without concern for process safety or energy waste. This work aimed to develop a mini carbonization system of three kilns coupled to a vertical smoke burner for optimized and environmentally correct charcoal and wood vinegar (WV) production on small farms. The project was divided into three parts for dimensioning: the three-kiln set, the WV condensing device, and the smoke burner. The condenser was designed following the procedures from the standards of TEMA (Tubular Exchangers Manufacturers Association); ASME (Society of Mechanical Engineers of the United States) Section VIII, Division 1; and the NR-13 (Regulatory Standard) of ABNT (Brazilian Association of Technical Standards). In contrast to the current scenario, in which primitive carbonization technologies are still employed, bringing about low charcoal yields and significant pollution release, the use of a mini-kiln that allows charcoal production and wood vinegar recovery combined with pollutant smoke burning is an interesting eco-friendly solution. Thus, the mini-kiln model presented here brings a low cost and environmental safety to the charcoal production chain, reaching sustainability parameters and offering higher income opportunities to small producers.
木炭是世界上最基本的能源之一,主要用于家庭和工业用途。巴西的木炭生产是在简陋的砖石窑中进行的,不考虑工艺安全和能源浪费。这项工作旨在开发一个由三个窑炉和一个垂直烟气燃烧器组成的小型碳化系统,以优化小型农场的木炭和木醋(WV)生产并保护环境。该项目分为三个部分进行尺寸设计:三窑装置、木醋冷凝装置和烟气燃烧器。冷凝器的设计遵循了 TEMA(管式交换器制造商协会)标准、ASME(美国机械工程师协会)第 VIII 章第 1 节和 ABNT(巴西技术标准协会)NR-13(监管标准)。目前,人们仍在使用原始的碳化技术,导致木炭产量低和污染严重,与此形成鲜明对比的是,使用小型焚化窑,既能生产木炭,又能回收木醋,还能燃烧污染物烟雾,是一种有趣的生态友好型解决方案。因此,这里介绍的迷你窑模式为木炭生产链带来了低成本和环境安全,达到了可持续发展参数,并为小生产者提供了更高的收入机会。
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引用次数: 0
Experimental Investigation of a Micro Turbojet Engine Chevrons Nozzle by Means of the Schlieren Technique 微型涡喷发动机涡形喷管纹影技术的实验研究
Q1 Engineering Pub Date : 2023-11-14 DOI: 10.3390/inventions8060145
Grigore Cican, Mihnea Gall, Alina Bogoi, Marius Deaconu, Daniel Eugeniu Crunțeanu
In connection with subsonic jet noise production, especially regarding the hot jet from a micro turbojet engine, we encountered a lack of recent high-resolution data in the literature describing the flow field using experimental validation through optical diagnoses. The objective of this paper is to examine and compare the influence on shear layers of the exhaust plug nozzle of a micro turbojet engine with and without chevrons mounted, using a high-speed camera used in Schlieren-type optical system diagnosis. Three different operating regimes are examined for both the baseline configuration and the configuration with 16 triangular-shaped chevrons. In conjunction with the image captures, the sound pressure level was recorded with the help of a microphone placed perpendicular to the flow, 0.4 m from the exhaust of the nozzle which was further processed. In quantitative terms, we found that the OASPL decreases by more than 1% when the engine is operating at higher regimes. Moreover, we found that the average exhaust jet angle, which is a measure of the quality of the fluid mixing layer is increased by 5% with respect to the baseline nozzle. By using the “darkest pixel” technique in Schlieren imaging, we can verify experimentally, for all working regimes, the theory that asserts that subsonic jet noise is a consequence of fine-scale homogeneous turbulence. Additionally, the potential novelty lies in the specific observations related to consistent dispersion of fine-scale eddies and how the presence of chevrons amplifies this uniformity within the turbulent field.
关于亚音速射流噪声的产生,特别是关于微型涡轮喷气发动机的热射流,我们遇到了文献中缺乏最近的高分辨率数据,这些数据通过光学诊断来描述流场的实验验证。本文的目的是利用一种用于纹影式光学系统诊断的高速摄像机,研究和比较安装和不安装chevrons的微型涡喷发动机排气塞喷嘴对剪切层的影响。对基线配置和具有16个三角形线形的配置检查了三种不同的操作制度。与图像捕获相结合,声压级在一个垂直于气流的麦克风的帮助下被记录下来,距离喷嘴的排气0.4 m,并进一步处理。在定量方面,我们发现当发动机在更高的工况下工作时,OASPL降低了1%以上。此外,我们发现平均排气喷射角(衡量流体混合层质量的一个指标)相对于基线喷嘴增加了5%。通过使用纹影成像中的“最暗像素”技术,我们可以在实验中验证,对于所有的工作体制,理论断言亚音速射流噪声是精细尺度均匀湍流的结果。此外,潜在的新颖性在于与精细尺度涡流的一致色散有关的具体观测,以及漩涡的存在如何放大湍流场中的这种均匀性。
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引用次数: 0
Optimization of Autoclave Reactors to Improve Bearing Life Using the Taguchi Method and the Response Surface Methodology 利用田口法和响应面法优化高压釜反应器以提高轴承寿命
Q1 Engineering Pub Date : 2023-11-10 DOI: 10.3390/inventions8060144
Farghani Fariz, Brijesh Patel, Hsien-Cheng Chiu, Shih-Jie Pan, Cheng-Liang Chen, Hao-Yeh Lee, Po Ting Lin
Plastic pervasiveness in daily life has increased in tandem with population growth. Ethylene–vinyl acetate (EVA) is emerging as a popular compound for manufacturing plastic, which is obtained from ethylene and vinyl acetate synthesis. EVA is produced using autoclave reactors, which often encounter bearing damage under specific operating conditions. This research aims to optimize the parameters in autoclave reactors to enhance bearing life. The study focuses on two crucial factors: the number of impellers and the temperature, with bearing life as the response variable. Simulations using finite-element analysis were conducted to obtain the fatigue life of bearings and validated using real-time company data stating the damage of bearings within 80 days. The optimization process employed the Taguchi method (TM) and the response surface methodology (RSM). A comparison of these techniques revealed that temperature had the most significant influence on the response. Interestingly, both methods yielded the same optimal parameters: seven impellers and a temperature of 150 °C. The simulation results using these optimized parameters demonstrated a noteworthy 3.095% increase in bearing life compared to the initial design. The RSM outperformed the Taguchi method in accurately predicting response values with minimum prediction error under optimal conditions.
随着人口的增长,塑料在日常生活中的普及程度也在增加。乙烯-醋酸乙烯酯(EVA)是由乙烯和醋酸乙烯合成而成的一种新兴的塑料原料。EVA是使用高压灭菌反应器生产的,在特定的操作条件下经常遇到轴承损坏。本研究旨在优化热压釜反应器的参数,以提高轴承寿命。研究重点是两个关键因素:叶轮数量和温度,轴承寿命作为响应变量。利用有限元分析进行了模拟,以获得轴承的疲劳寿命,并使用公司实时数据验证了轴承在80天内的损坏情况。优化过程采用田口法(TM)和响应面法(RSM)。对这些技术的比较表明,温度对响应的影响最为显著。有趣的是,两种方法都得到了相同的最佳参数:7个叶轮和150°C的温度。使用这些优化参数的仿真结果表明,与初始设计相比,轴承寿命提高了3.095%。在最优条件下,RSM能以最小的预测误差准确预测响应值,优于田口法。
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引用次数: 0
The Potential of Lakes for Extracting Renewable Energy—A Case Study of Brates Lake in the South-East of Europe 湖泊提取可再生能源的潜力——以欧洲东南部布雷茨湖为例
Q1 Engineering Pub Date : 2023-11-09 DOI: 10.3390/inventions8060143
Eugen Rusu, Puiu Lucian Georgescu, Florin Onea, Victoria Yildirir, Silvia Dragan
The aim of this work is to provide some details regarding the energy potential of the local wind and solar resources near the Galati area (south-east of Romania) by considering the performances of a few recent technologies. Based on 22 years of ERA5 data (2001–2022), a picture concerning the renewable energy resources in the Brates Lake area is provided. Comparing the wind and solar resources with in situ and satellite data, a relatively good agreement was found, especially in regards to the average values. In terms of wind speed conditions at a hub height of 100 m, we can expect a maximum value of 19.28 m/s during the winter time, while for the solar irradiance the energy level can reach up to 932 W/m2 during the summer season. Several generators of 2 MW were considered for evaluation, for which a state-of-the-art system of 6.2 MW was also added. The expected capacity factor of the turbines is in the range of (11.71–21.23)%, with better performances being expected from the Gamesa G90 generator. As a next step, several floating solar units were considered in order to simulate large-scale solar projects that may cover between 10 and 40% of the Brates Lake surface. The amount of the evaporated water saved by these solar panels was also considered, being estimated that the water demand of at least 3.42 km2 of the agricultural areas can be covered on an annual scale.
这项工作的目的是通过考虑一些最新技术的性能,提供有关加拉蒂地区(罗马尼亚东南部)附近当地风能和太阳能资源的能源潜力的一些细节。基于ERA5的22年数据(2001-2022年),给出了Brates湖区可再生能源的分布图。将风能和太阳能资源与现场和卫星数据进行比较,发现了比较好的一致性,特别是在平均值方面。在轮毂高度为100 m的风速条件下,冬季最高可达19.28 m/s,而夏季太阳辐照度最高可达932 W/m2。考虑了几台2兆瓦的发电机进行评估,其中还增加了一套最先进的6.2兆瓦系统。涡轮机的预期容量系数在(11.71-21.23)%的范围内,预计Gamesa G90发电机的性能会更好。下一步,几个浮动太阳能装置被考虑用于模拟大型太阳能项目,这些项目可能覆盖Brates湖表面的10%到40%。还考虑了这些太阳能电池板节省的蒸发水量,据估计,每年至少可以覆盖3.42平方公里的农业区的用水需求。
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引用次数: 0
A New MPPT-Based Extended Grey Wolf Optimizer for Stand-Alone PV System: A Performance Evaluation versus Four Smart MPPT Techniques in Diverse Scenarios 一种新的基于MPPT的独立光伏系统扩展灰狼优化器:不同场景下四种智能MPPT技术的性能评估
Q1 Engineering Pub Date : 2023-11-07 DOI: 10.3390/inventions8060142
Mohammed Yousri Silaa, Oscar Barambones, Aissa Bencherif, Abdellah Rahmani
Photovoltaic (PV) systems play a crucial role in clean energy systems. Effective maximum power point tracking (MPPT) techniques are essential to optimize their performance. However, conventional MPPT methods exhibit limitations and challenges in real-world scenarios characterized by rapidly changing environmental factors and various operating conditions. To address these challenges, this paper presents a performance evaluation of a novel extended grey wolf optimizer (EGWO). The EGWO has been meticulously designed in order to improve the efficiency of PV systems by rapidly tracking and maintaining the maximum power point (MPP). In this study, a comparison is made between the EGWO and other prominent MPPT techniques, including the grey wolf optimizer (GWO), equilibrium optimization algorithm (EOA), particle swarm optimization (PSO) and sin cos algorithm (SCA) techniques. To evaluate these MPPT methods, a model of a PV module integrated with a DC/DC boost converter is employed, and simulations are conducted using Simulink-MATLAB software under standard test conditions (STC) and various environmental conditions. In particular, the results demonstrate that the novel EGWO outperforms the GWO, EOA, PSO and SCA techniques and shows fast tracking speed, superior dynamic response, high robustness and minimal power fluctuations across both STC and variable conditions. Thus, a power fluctuation of 0.09 W could be achieved by using the proposed EGWO technique. Finally, according to these results, the proposed approach can offer an improvement in energy consumption. These findings underscore the potential benefits of employing the novel MPPT EGWO to enhance the efficiency and performance of MPPT in PV systems. Further exploration of this intelligent technique could lead to significant advancements in optimizing PV system performance, making it a promising option for real-world applications.
光伏(PV)系统在清洁能源系统中起着至关重要的作用。有效的最大功率点跟踪(MPPT)技术是优化其性能的关键。然而,在快速变化的环境因素和各种操作条件下,传统的MPPT方法存在局限性和挑战。为了解决这些挑战,本文提出了一种新的扩展灰狼优化器(EGWO)的性能评估。EGWO经过精心设计,通过快速跟踪和保持最大功率点(MPP)来提高光伏系统的效率。在本研究中,EGWO与其他著名的MPPT技术,包括灰狼优化器(GWO)、平衡优化算法(EOA)、粒子群优化(PSO)和sin cos算法(SCA)技术进行了比较。为了评估这些MPPT方法,采用集成DC/DC升压变换器的光伏模块模型,并使用Simulink-MATLAB软件在标准测试条件(STC)和各种环境条件下进行仿真。特别是,结果表明,新型EGWO技术优于GWO、EOA、PSO和SCA技术,并且在STC和可变条件下都具有快速的跟踪速度、优异的动态响应、高鲁棒性和最小的功率波动。因此,使用所提出的EGWO技术可以实现0.09 W的功率波动。最后,根据这些结果,所提出的方法可以提供能源消耗的改善。这些发现强调了采用新型MPPT EGWO来提高光伏系统中MPPT的效率和性能的潜在好处。对这种智能技术的进一步探索可能会在优化光伏系统性能方面取得重大进展,使其成为现实世界应用的一个有前途的选择。
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引用次数: 0
Patent Parasites: Non-Inventors Patenting Existing Open-Source Inventions in the 3-D Printing Technology Space 专利寄生虫:非发明者在3d打印技术领域为现有开源发明申请专利
Q1 Engineering Pub Date : 2023-11-06 DOI: 10.3390/inventions8060141
Apoorv Kulkarni, Joshua M. Pearce
Open-source 3-D printing has played a pivotal role in revolutionizing the additive manufacturing (AM) landscape by making distributed manufacturing economic, democratizing access, and fostering far more rapid innovation than antiquated proprietary systems. Unfortunately, some 3-D printing manufacturing companies began deviating from open-source principles and violating licenses for the detriment of the community. To determine if a pattern has emerged of companies patenting clearly open-source innovations, this study presents three case studies from the three primary regions of open-source 3-D printing development (EU, U.S., and China) as well as three aspects of 3-D printing technology (AM materials, an open-source 3-D printer, and core open-source 3-D printing concepts used in most 3-D printers). The results of this review have shown that non-inventing entities, called patent parasites, are patenting open-source inventions already well-established in the open-source community and, in the most egregious cases, commercialized by one (or several) firm(s) at the time of the patent filing. Patent parasites are able to patent open-source innovations by using a different language, vague patent titles, and broad claims that encompass enormous swaths of widely diffused open-source innovation space. This practice poses a severe threat to innovation, and several approaches to irradicate the threat are discussed.
开源3d打印通过使分布式制造变得经济、使访问民主化,以及促进比过时的专有系统更快的创新,在彻底改变增材制造(AM)领域发挥了关键作用。不幸的是,一些3d打印制造公司开始偏离开源原则,违反许可证,损害了社区的利益。为了确定是否已经出现了一种明显开源创新的专利模式,本研究提出了三个案例研究,分别来自开源3d打印发展的三个主要地区(欧盟、美国和中国),以及3d打印技术的三个方面(AM材料、开源3d打印机和大多数3d打印机中使用的核心开源3d打印概念)。这项审查的结果表明,被称为专利寄生虫的非发明实体正在为开源社区中已经建立的开源发明申请专利,并且在最令人震惊的情况下,在专利申请时由一家(或几家)公司商业化。专利寄生虫能够通过使用不同的语言、模糊的专利名称和广泛的声明来为开源创新申请专利,这些声明包含了广泛传播的开源创新空间的巨大区域。这种做法对创新构成了严重的威胁,并讨论了几种消除威胁的方法。
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引用次数: 0
Extruder Machine Gear Fault Detection Using Autoencoder LSTM via Sensor Fusion Approach 基于传感器融合的自编码器LSTM挤出机齿轮故障检测
Q1 Engineering Pub Date : 2023-11-02 DOI: 10.3390/inventions8060140
Joon-Hyuk Lee, Chibuzo Nwabufo Okwuosa, Jang-Wook Hur
In industrial settings, gears play a crucial role by assisting various machinery functions such as speed control, torque manipulation, and altering motion direction. The malfunction or failure of these gear components can have serious repercussions, resulting in production halts and financial losses. To address this need, research efforts have focused on early defect detection in gears in order to reduce the impact of possible failures. This study focused on analyzing vibration and thermal datasets from two extruder machine gearboxes using an autoencoder Long Short-Term Memory (AE-LSTM) model, to ensure that all important characteristics of the system are utilized. Fast independent component analysis (FastICA) is employed to fuse the data signals from both sensors while retaining their characteristics. The major goal is to implement an outlier detection approach to detect and classify defects. The results of this study highlighted the extraordinary performance of the AE-LSTM model, which achieved an impressive accuracy rate of 94.42% in recognizing malfunctioning gearboxes within the extruder machine system. The study used robust global metric evaluation techniques, such as accuracy, F1-score, and confusion metrics, to thoroughly evaluate the model’s dependability and efficiency. LSTM was additionally employed for anomaly detection to further emphasize the adaptability and interoperability of the methodology. This modification yielded a remarkable accuracy of 89.67%, offering additional validation of the model’s reliability and competence.
在工业环境中,齿轮通过协助各种机械功能(如速度控制,扭矩操纵和改变运动方向)起着至关重要的作用。这些齿轮部件的故障或失败可能会产生严重的影响,导致生产停止和经济损失。为了满足这一需求,研究工作集中在齿轮的早期缺陷检测上,以减少可能的故障的影响。本研究的重点是使用自动编码器长短期记忆(AE-LSTM)模型分析两台挤出机齿轮箱的振动和热数据集,以确保系统的所有重要特性都得到利用。采用快速独立分量分析(FastICA)融合来自两个传感器的数据信号,同时保持其特性。主要目标是实现一种异常检测方法来检测和分类缺陷。本研究的结果突出了AE-LSTM模型的非凡性能,该模型在识别挤出机系统内故障齿轮箱方面达到了令人印象深刻的94.42%的准确率。该研究使用了鲁棒的全局度量评估技术,如准确性、f1评分和混淆度量,以彻底评估模型的可靠性和效率。此外,还采用LSTM进行异常检测,进一步强调了方法的适应性和互操作性。这一修正获得了89.67%的显著准确率,进一步验证了模型的可靠性和能力。
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引用次数: 0
Effect of Different Contents of 63s Bioglass on the Performance of Bioglass-PCL Composite Bone Scaffolds 不同含量63s生物玻璃对生物玻璃- pcl复合骨支架性能的影响
Q1 Engineering Pub Date : 2023-10-30 DOI: 10.3390/inventions8060138
Chen Zhang, Shihao Chen, Muniyandi Vigneshwaran, Yi Qi, Yulai Zhou, Gaosheng Fu, Zhiyu Li, Jianlei Wang
Bioactive glasses (BG), notably 63s BG, possess distinct properties such as biodegradability, biocompatibility, and the ability to boost cellular interactions. Our research concentrated on formulating polycaprolactone (PCL) porous scaffolds enriched with 63s BG to gauge their combined mechanical and biological potentials. Using twin-screw extrusion, we created composites containing 5%, 10%, and 20% 63s BG. These were transformed into cylindrical scaffolds using 3D printing. Our assessments involved melt flow, SEM, XRD, water contact angle metrics, DSC, and extracorporeal degradation. After co-culturing with MC3T3-E1 cells, an uptick in alkaline phosphatase activity was noted. Preliminary findings demonstrated that as 63s BG content increased, the properties of the composites improved. Yet, they fell short of replicating the mechanical nuances of cortical bone, rendering them inapt for load-bearing orthopedic applications but suitable for mending minor bone defects or cartilage. In summary, while 63s BG brings about significant advancements in scaffold attributes, attaining the mechanical traits ideal for certain medical purposes remains elusive. This investigation offers foundational insights for the evolution of optimized bone tissue engineering materials.
生物活性玻璃(BG),特别是63s BG,具有独特的特性,如生物可降解性、生物相容性和促进细胞相互作用的能力。我们的研究重点是制备富含63s BG的聚己内酯(PCL)多孔支架,以测定其综合力学和生物学电位。使用双螺杆挤压,我们制造了含有5%,10%和20% 63s BG的复合材料。使用3D打印技术将这些支架转化为圆柱形支架。我们的评估包括熔体流动、SEM、XRD、水接触角、DSC和体外降解。与MC3T3-E1细胞共培养后,发现碱性磷酸酶活性有所上升。初步结果表明,随着63s BG含量的增加,复合材料的性能得到改善。然而,它们无法复制皮质骨的机械细微差别,这使得它们不适用于承重骨科应用,但适合修复轻微的骨缺陷或软骨。总之,虽然63s BG在支架属性方面取得了重大进展,但实现某些医疗目的的理想机械特性仍然难以捉摸。这项研究为优化骨组织工程材料的发展提供了基础的见解。
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引用次数: 0
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