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2017 IEEE International Conference on Plasma Science (ICOPS)最新文献

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Cancer Inhibiting Properties From Self-Organized Plasma-Liquid Interface: In Vitro Demonstration 自组织等离子体-液体界面的抑癌特性:体外验证
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496369
Zhitong Chen, Shiqiang Zhang, I. Levchenko, I. Beilis, M. Keidar
Self-organization is intrinsic to complex non-living systems; albeit not in such ubiquitous amount, it still plays important role in some physical systems [1]. In this work, we present a novel approach which demonstrates nontrivial cancer-inhibiting capabilities of spontaneous pattern-forming self-organization at the interface between atmospheric pressure glow discharge plasma and liquid media. A pronounced cancer depressing activity towards at least two kinds of human cancer cells, namely breast cancer MDAMB-231 and human glioblastoma U87 cancer lines, was demonstrated. After a short treatment at the thinly stratified selforganized plasma-liquid interface pattern, the cancer inhibiting media demonstrate well pronounced depression and apoptosis activities towards tumor cells, not achievable without interfacial stratification of plasma jet to thin (of several μm) current filaments, which therefore play a pivotal (yet still not completely clear) role in building up the cancer inhibition properties. Moreover, thinly stratified, self-organized interfacial discharge is capable to efficiently control the ROS and RNS concentrations in the cancerinhibiting media, and in particular, abnormal ROS/RNS ratios not achievable in discharges which do not form stratified thin-filament patterns could be obtained [2, 3]. These results were explained in terms of interaction of thin plasma filaments of the self-organized pattern with gas and liquid, where the unusual interaction conditions (i.e., high surface-to-volume ratios etc.) cause accumulation of ROS, RNS and other species in unusual ratios and concentrations, thus forming potentially efficient anti-cancer cocktail. Our funding could be extremely important for handling the cancer proliferation problem, and hence, it should be brought to light to attract due attention of the researchers and explore the possible potential of this approach in tackling the challenging problem of high cancer-induced mortality and rising morbidity trends.
自组织是复杂的非生命系统所固有的;虽然不是无处不在,但它在一些物理系统中仍然发挥着重要作用[1]。在这项工作中,我们提出了一种新的方法,证明了在大气压辉光放电等离子体和液体介质之间的界面上自发模式形成的自组织具有非凡的抗癌能力。对至少两种人类癌细胞,即乳腺癌MDAMB-231和人类胶质母细胞瘤U87癌细胞,显示出明显的抑癌活性。在薄层自组织等离子体-液体界面模式下短暂处理后,抑癌介质对肿瘤细胞表现出明显的抑制和凋亡活性,如果没有等离子体喷射到薄(几μm)电流细丝的界面分层,这是无法实现的,因此,这在建立抑癌特性中起着关键(但仍不完全清楚)的作用。此外,薄层、自组织的界面放电能够有效地控制肿瘤抑制介质中的ROS和RNS浓度,特别是在不形成分层薄丝模式的放电中,可以获得不可能实现的异常ROS/RNS比率[2,3]。这些结果是用自组织模式的薄等离子体细丝与气体和液体的相互作用来解释的,其中不寻常的相互作用条件(即高表面体积比等)导致ROS, RNS和其他物种以不寻常的比例和浓度积累,从而形成潜在的高效抗癌鸡尾酒。我们的资金可能对处理癌症扩散问题非常重要,因此,它应该被曝光,以吸引研究人员的适当关注,并探索这种方法在解决癌症引起的高死亡率和发病率上升趋势这一具有挑战性的问题上的可能潜力。
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引用次数: 1
Electric Field Breakdown Versus Frequency Simulated Under Atmospheric Conditions For Large Gaps 大间隙大气条件下电场击穿随频率的模拟
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496212
Hieu K. A. Nguyen, A. Chowdhury, J. Dickens, R. Joshi, A. Neuber
Breakdown of air at atmospheric pressure in response to AC fields in gaps larger than 1 cm was simulated. Most previous literature concerning breakdown in this regime has focused on much smaller gaps1
模拟了空气在大气压下对大于1cm的交流电场的击穿反应。以前大多数关于这一体系崩溃的文献都集中在小得多的间隙上
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引用次数: 0
Paschen Curve for Helium in 100–1000 KV Range 100 - 1000kv范围内氦的Paschen曲线
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496335
A. Khrabrov, Liang Xu, I. Kaganovich, T. Sommerer
The left branch of the Paschen curve for helium gas is studied both experimentally and by means of particle-in-cell/Monte Carlo collisions (PIC/MCC) simulations. The physical model incorporates electron, ion, and fast atom species whose energy-dependent anisotropic scattering on background neutrals, as well as backscattering at the electrodes, is properly accounted for. For the range of breakdown voltage 15 kV ≤ Vbr ≤ 130 kV, a good agreement is observed between simulations and available experimental results for the discharge gap d = 1.4 cm. The PIC/MCC model is then used to estimate the Paschen curve at higher voltages up to 1 MV, based on the availability of input atomic data. We find that the pd similarity scaling does hold, and that above 300 kV the value of pd at breakdown begins to increase with increasing voltage.
通过实验和粒子池/蒙特卡罗碰撞(PIC/MCC)模拟研究了氦气的Paschen曲线左分支。物理模型包含了电子、离子和快原子,它们的能量依赖于背景中性的各向异性散射,以及电极的后向散射,都得到了适当的考虑。在击穿电压15 kV≤Vbr≤130 kV范围内,放电间隙d = 1.4 cm时,仿真结果与已有实验结果吻合较好。然后根据输入原子数据的可用性,使用PIC/MCC模型在高达1 MV的较高电压下估计Paschen曲线。我们发现pd相似标度确实成立,并且在300 kV以上击穿时pd值开始随着电压的增加而增加。
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引用次数: 0
Process Of Arc Moving Affected By External Magnetic Field In Magnetic Driven Arc 磁驱动电弧中外磁场对电弧运动过程的影响
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496089
Yutaro Inuzuka, Takashi Yamato, Shinji Yamamoto, T. Iwao
Magnetic driven arc has been applied to DC breaker and fault current limiters. However, it has not been researched, especially stagnation and re-strike of the arc. In this paper, the process of arc moving affected by external magnetic field in magnetic driven arc is elucidated. Specifically, the behavior of magnetic driven arc with external magnetic field is measured by using the oscilloscope and HSVC (High Speed Video Camera). And an external magnetic field (1, 2, 3 mT) was applied by helmholtz coil. As a result, the arc mean moving speed increases with increasing the external magnetic field. The arc of re-strike time increases and stalemate time decreases with increasing the external magnetic field. Therefore, the anode spot moving speed increases 8 times because arc of re-strike occurs easily with the external magnetic field. Thus, the erosion of electrodes decreases and the arc moving becomes the smooth. However, the distance of re-strike decreases with increasing the external magnetic field because re-strike point is affected by cathode jet. The anode restrikes on the extension of the cathode jet. Therefore, the direction of cathode jet contributes to the process of arc moving.
磁驱动电弧已应用于直流断路器和故障限流器。但是,对电弧的滞止和重击等问题的研究还很少。本文阐述了磁驱动电弧在外加磁场作用下的电弧运动过程。具体地说,利用示波器和高速摄像机测量了外磁场作用下磁驱动电弧的行为。亥姆霍兹线圈外加磁场(1,2,3 mT)。结果表明,电弧平均移动速度随外加磁场的增大而增大。随着外加磁场的增大,重击弧时间增大,相持弧时间减小。因此,由于外加磁场容易产生重击电弧,阳极点移动速度提高了8倍。因此,电极的侵蚀减少,电弧的移动变得平滑。但由于阴极射流对重击点的影响,重击距离随外加磁场的增大而减小。阳极再冲击阴极射流的延伸。因此,阴极射流的方向有助于电弧的运动过程。
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引用次数: 0
Distribution Of Vapor Density Affected By Cathode Spot Area Of Vacuum Arc 真空电弧阴极光斑面积对蒸汽密度分布的影响
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8495986
Soshi Iwata, Shinji Yamamoto, T. Iwao
Establishment of surface treatment technology using vacuum arc is expected in order to form a recycling-oriented society. Thus, it is required for elucidation of the quantity of vapor exerted by the area of vacuum arc cathode spot. However, it is difficult to elucidate this phenomenon with the experiment because the vacuum arc cathode spot is high temperature and high speed. Therefore, it is expected to elucidate this phenomenon with simulation. In this paper, the distribution of vapor density affected by the area of vacuum arc cathode spot is elucidated with 3D electromagnetic thermal fluid simulation. As a result, the quantity of metal vapor decreases with increasing the area of cathode spot. Because the current density decreases with increasing the area of cathode spot. Thus, Joule heat generation in the space decreases, and heat input to the cathode decreases. Therefore, the quantity of metal vapor decreases with increasing the area of cathode spot. In the future, the asymmetric distribution of vapor density is analyzed in order to control the cathode spot with the transverse magnetic field.
建立真空电弧表面处理技术,形成循环型社会是有希望的。因此,需要对真空电弧阴极点面积所施加的蒸气量进行说明。但由于真空电弧阴极光斑温度高、速度快,用实验很难解释这一现象。因此,期望用模拟来阐明这一现象。本文采用三维电磁热流体模拟的方法,研究了真空电弧阴极点面积对蒸汽密度分布的影响。结果表明,随着阴极光斑面积的增大,金属气相的数量减少。因为电流密度随阴极光斑面积的增大而减小。因此,空间中的焦耳热产生减少,阴极的热输入减少。因此,随着阴极光斑面积的增大,金属气相的数量减少。今后,为了利用横向磁场控制阴极光斑,需要进一步分析气相密度的不对称分布。
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引用次数: 0
Treatment on Neuroblastoma Cancer Cells Using Atmospheric Cold Plasma 大气冷等离子体治疗神经母细胞瘤癌细胞
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496306
Magesh T. Rajan, Krishna Patel, Sreeja Vemulapalli, Nandini Pokala
Non-thermal atmospheric plasma is an ambient temperature ionized gas acquiring significant attention as a favorable addition to anti-tumor treatment mainly due to the capability to produce and regulate delivery of ions, excited molecules, UV photons, and reactive species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) to a targeted site. The heterogeneous composition of non-thermal atmospheric plasma offers the opportunity to intervene numerous signaling pathways that control tumor cells. Subsequently, the array of non-thermal atmospheric plasma generated products has limited the identification of the mechanisms of action on tumor cells. In this work, we will present the results of non-thermal plasma jet treated on neuroblastoma cells using a murine neuroblastoma line derived from AJ mice and cultured in D10 media. The goal of this work is to determine the cell death response of neuroblastoma cells by using a non-thermal plasma jet. The effect of variable treatment dosage levels of non-thermal plasma was tested in neuroblastoma cells. The number of viable cells was evaluated, while apoptosis and necrosis was assessed. Our observations indicate that increased treatment dosage levels of non-thermal plasma jet caused varied results from no significant changes to apoptotic characteristics to induction of necrosis at extended dosages. Overall the results suggest that non-thermal plasma jet can be of significant application to the treatment of neuroblastoma cancer cells.
非热大气等离子体是一种环境温度电离气体,作为抗肿瘤治疗的有利补充而受到广泛关注,主要是因为它能够产生和调节离子、受激分子、紫外线光子和活性物质(如活性氧(ROS)和活性氮(RNS))向目标部位的传递。非热大气等离子体的异质性组成为干预控制肿瘤细胞的许多信号通路提供了机会。随后,非热大气等离子体产生的产物阵列限制了对肿瘤细胞作用机制的识别。在这项工作中,我们将展示非热等离子体射流处理神经母细胞瘤细胞的结果,使用来自AJ小鼠并在D10培养基中培养的小鼠神经母细胞瘤细胞系。这项工作的目的是利用非热等离子体射流确定神经母细胞瘤细胞的细胞死亡反应。在神经母细胞瘤细胞中测试了不同剂量的非热等离子体治疗的效果。评估活细胞数量,同时评估凋亡和坏死。我们的观察表明,增加非热等离子体射流的治疗剂量水平会导致不同的结果,从对凋亡特征没有显著改变到在大剂量下诱导坏死。结果表明,非热等离子体射流在神经母细胞瘤肿瘤细胞的治疗中具有重要的应用价值。
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引用次数: 0
Influence of External Electric Field Boundary Conditions on Electrospray Emissions 外电场边界条件对电喷雾辐射的影响
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496114
Neil A. Mehta, D. Levin
Emission characteristics of a colloid thruster or electrospray depends strongly on the electrochemical property of the ionic liquid as well as its response to the external electric field. Using molecular dynamics, the evolution of the Taylor cone formation for an electrospray device can be analyzed at an atomic level. From our previous work1, it was observed that the electric field strengths required to create and sustain a stable Taylor cone are correlated to the internal nanostructure of the propellant ionic liquid. The location of the applied extraction potential with respect to the capillary produces differences in the strength and the shape of the resulting external electric fields. The varying electric fields are strongest at the mouth of the capillary and affect the emission rate, Taylor cone stability, as well as the internal nanostructure of the ionic liquid. In this work, we will study the effects of variable electric field shape and strength on the Taylor cone structure.
胶体推力器或电喷雾的发射特性在很大程度上取决于离子液体的电化学性质及其对外部电场的响应。利用分子动力学,可以在原子水平上分析电喷雾装置泰勒锥形成的演变。从我们之前的工作中,我们观察到,产生和维持稳定的泰勒锥所需的电场强度与推进剂离子液体的内部纳米结构有关。所施加的萃取电位相对于毛细管的位置产生的外电场的强度和形状的差异。变化的电场在毛细管口处最强,影响离子液体的发射速率、泰勒锥稳定性以及内部纳米结构。在这项工作中,我们将研究可变电场形状和强度对泰勒锥结构的影响。
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引用次数: 0
Plasma Gasification Of Biomedical Waste 生物医学废物的等离子气化
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496382
V. Messerle, A. Mosse, G. Paskalov, A. Ustimenko
An acute problem is the disposal of Biomedical Wastes (BMW) containing toxic substances. Plasma gasification is a promising technology for BMW disposal. In contrast to the traditional fire method of BMW processing plasma gasification of BMW provides reliable destruction of highly toxic dioxins, benzo(a)pyrene and furans. This report presents the results of thermodynamic analysis and experiments on plasma gasification of BMW.
一个严重的问题是处理含有有毒物质的生物医学废物。等离子气化是一种很有前途的宝马处理技术。与传统的宝马火处理方法相比,等离子气化宝马提供了可靠的高毒性二恶英,苯并(a)芘和呋喃的破坏。本文介绍了宝马等离子体气化的热力学分析和实验结果。
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引用次数: 0
Bioactive and Antibacterial Plasma Sprayed Coatings on Polymer Substrates Suitable for Orthopedic and Tissue Engineering Applications 适用于骨科和组织工程应用的聚合物基板的生物活性和抗菌等离子喷涂涂料
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496356
L. Barillas, J. M. Cubero-Sesin, V. Vargas, H. Testrich, Maik Froehlich, K. Weltmann, M. Polák
Nowadays, the use of polymers in modern orthopedics has become more common, not only because they can play an important role due to their weight, cost and performance; but also thanks to new manufacturing and processing technologies –mainly additive manufacturing or 3D printing–. Their application to polymers has allowed a wide range of medical devices to change from expensive and generic devices (“one size fits all”), to customized and more affordable options, being orthopedic implants one of the best examples of this revolution.
如今,聚合物在现代骨科中的使用已经变得越来越普遍,这不仅是因为它们的重量,成本和性能可以发挥重要作用;还得益于新的制造和加工技术——主要是增材制造或3D打印。它们在聚合物上的应用使各种医疗设备从昂贵的通用设备(“一刀切”)转变为定制的更实惠的选择,骨科植入物是这场革命的最佳例子之一。
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引用次数: 1
Experimental Measurements of Power Extraction Circuits For Mobile Ionospheric Heating* 移动电离层加热功率提取电路的实验测量*
Pub Date : 2017-05-01 DOI: 10.1109/PLASMA.2017.8496205
B. Beaudoin, A. Ting, S. Gold, J. A. Karakkad, A. Narayan, G. Nusinovich, Charles Turner, T. Antonsen
A mobile heater for ionospheric modification studies will require a new megawatt class RF source operating with an antenna array that is 1/20 the area of HAARP [1]. In order to deliver an effective power density comparable to that of HAARP, the total source power must be in the range of 16 MW, thus demanding highly efficient sources [2]. The source design we are currently pursuing utilizes a grid-less electron gun that uses a mod-anode to turn a thin annular beam on and off in class D operation. The beam is passed through a decelerating gap and its kinetic energy is extracted using a tunable resonant circuit that presents a constant impedance over the frequency range of 3–10 MHz, such that the beam is almost decelerated at all frequencies.
用于电离层改造研究的移动加热器将需要一个新的兆瓦级射频源,其天线阵列的面积为HAARP的1/20[1]。为了提供与HAARP相当的有效功率密度,源总功率必须在16 MW范围内,因此需要高效率的源[2]。我们目前正在进行的源设计采用了一种无网格电子枪,该电子枪使用模态阳极在D级操作中打开和关闭薄环形光束。光束通过减速间隙,并使用可调谐谐振电路提取其动能,该电路在3-10 MHz的频率范围内呈现恒定阻抗,从而使光束在所有频率上几乎减速。
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引用次数: 0
期刊
2017 IEEE International Conference on Plasma Science (ICOPS)
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