Pub Date : 2021-07-01DOI: 10.22038/IJN.2021.49155.1885
Z. Mosayebi, T. E. Shirvani, Vafa Ghorban Sabagh, Maryam Ghavami-Adel, Bahareh Fasihpour, Hosein Dalili, A. Fathi
Background: Abdominal masses secondary to urinary retention are rare among female neonates and approaching this pathologic condition, inevitably, poses a diagnostic challenge. Hydrometrocolpos is one example of this disease category which is responsible for only 15% of such cases whose association with polydactyly appears to be even less common. The present study aimed to report the accounts of two neonates with cystic abdominal masses diagnosed as urinary type hydrometrocolpos secondary to urogenital sinus anomaly. Autosomal recessive disorders are characterized by vaginal atresia with hydrometrocolpos, polydactyly, congenital heart defects, and non-immune mediated hydrops fetalis. The triad of hydrometrocolpos, polydactyly, and cardiac anomaly in the two patients presented herein is strongly suggestive of a case of McKusick-Kaufman syndrome. Case report: This study reported two neonates with abdominal mass, polydactyly, and genitourinary tract malformation, with no family history. Relief of urinary obstruction by exploratory laparotomy, aspiration of fluid, and vaginal reconstruction gradually reversed the hydronephrosis and renal failure. Conclusion: It can be concluded thatin hydrometrocolpos causing urinary obstruction, decompression of hydrometrocolpos can save the kidneys.
{"title":"Urinary Type Hydrometrocolpos and Polydactyly in Two Newborns: Case Report","authors":"Z. Mosayebi, T. E. Shirvani, Vafa Ghorban Sabagh, Maryam Ghavami-Adel, Bahareh Fasihpour, Hosein Dalili, A. Fathi","doi":"10.22038/IJN.2021.49155.1885","DOIUrl":"https://doi.org/10.22038/IJN.2021.49155.1885","url":null,"abstract":"Background: Abdominal masses secondary to urinary retention are rare among female neonates and approaching this pathologic condition, inevitably, poses a diagnostic challenge. Hydrometrocolpos is one example of this disease category which is responsible for only 15% of such cases whose association with polydactyly appears to be even less common. The present study aimed to report the accounts of two neonates with cystic abdominal masses diagnosed as urinary type hydrometrocolpos secondary to urogenital sinus anomaly. Autosomal recessive disorders are characterized by vaginal atresia with hydrometrocolpos, polydactyly, congenital heart defects, and non-immune mediated hydrops fetalis. The triad of hydrometrocolpos, polydactyly, and cardiac anomaly in the two patients presented herein is strongly suggestive of a case of McKusick-Kaufman syndrome. \u0000Case report: This study reported two neonates with abdominal mass, polydactyly, and genitourinary tract malformation, with no family history. Relief of urinary obstruction by exploratory laparotomy, aspiration of fluid, and vaginal reconstruction gradually reversed the hydronephrosis and renal failure. \u0000Conclusion: It can be concluded thatin hydrometrocolpos causing urinary obstruction, decompression of hydrometrocolpos can save the kidneys.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"11 1","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86271129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22038/IJN.2021.47920.1821
Sosnowska Patrycja, Mańkowski Przemysław
Background: Congenital duodenal atresia (CDA) is a common and surgically treated digestive tract anomaly that develops in the early stage of pregnancy. It often coexists with trisomy 21 and other inborn defects. Surgery is the only way of treatment. This study aimed to investigate the relationship of CDA with early diagnosis, course of pregnancy, coexisting congenital defects, and further development of children. Methods: The data were collected using the medical history and a self-designed survey which consisted of 22 questions about the perinatal interview, coexisting inborn defects, after birth symptoms, time and methods of diagnosis, as well as the treatment outcome. Results: The surveys were sent to 31 patients who were diagnosed and treated because of CDA in our clinic between 2004 and 2019. According to the collected data, 73.7% of the patients were diagnosed prenatally with the mean time of diagnosis at 28th weeks of gestation. Moreover, 37% of the patients were preborn, and almost half of the patients had low and very low body weight. More than 2/3 of children presented coexisting inborn abnormalities. Among after birth symptoms, the most common ones were abdominal distention and lack of meconium. The majority of children were operated within 24 hours after birth. Conclusions: Prenatal diagnosis of CDA results in an earlier time of primary operation. Newborns diagnosed antenatally present fewer symptoms after the operation, fewer reoperations, and a shorter time of oral feeding toleration. The coexistence of other congenital defects increases patients’ mortality. The important factors that deteriorate the postoperative course are prematurity and low body weight. In order to avoid long-term complications, it is of utmost importance to provide follow-up.
{"title":"Congenital Duodenal Atresia Diagnosis, Treatment, and Influence on Further Development of Patients","authors":"Sosnowska Patrycja, Mańkowski Przemysław","doi":"10.22038/IJN.2021.47920.1821","DOIUrl":"https://doi.org/10.22038/IJN.2021.47920.1821","url":null,"abstract":"Background: Congenital duodenal atresia (CDA) is a common and surgically treated digestive tract anomaly that develops in the early stage of pregnancy. It often coexists with trisomy 21 and other inborn defects. Surgery is the only way of treatment. This study aimed to investigate the relationship of CDA with early diagnosis, course of pregnancy, coexisting congenital defects, and further development of children. \u0000Methods: The data were collected using the medical history and a self-designed survey which consisted of 22 questions about the perinatal interview, coexisting inborn defects, after birth symptoms, time and methods of diagnosis, as well as the treatment outcome. \u0000Results: The surveys were sent to 31 patients who were diagnosed and treated because of CDA in our clinic between 2004 and 2019. According to the collected data, 73.7% of the patients were diagnosed prenatally with the mean time of diagnosis at 28th weeks of gestation. Moreover, 37% of the patients were preborn, and almost half of the patients had low and very low body weight. More than 2/3 of children presented coexisting inborn abnormalities. Among after birth symptoms, the most common ones were abdominal distention and lack of meconium. The majority of children were operated within 24 hours after birth. \u0000Conclusions: Prenatal diagnosis of CDA results in an earlier time of primary operation. Newborns diagnosed antenatally present fewer symptoms after the operation, fewer reoperations, and a shorter time of oral feeding toleration. The coexistence of other congenital defects increases patients’ mortality. The important factors that deteriorate the postoperative course are prematurity and low body weight. In order to avoid long-term complications, it is of utmost importance to provide follow-up.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"52 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85713581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22038/IJN.2021.52183.1930
Fetlework Aneteneh, E. Sendo, T. Gebretensaye
Background: Periconceptional folic acid supplementation is an effective way to prevent neural tube defects (NTDs) and other congenital anomalies. It is shown that 9.7% of healthcare providers practiced periconceptional folic acid supplements in Ethiopia. Fewer than 50% of women receive information on folic acid before or only during pregnancy. This study was conducted to assess folic acid supplementation counseling practices among health care providers.Methods: This institution-based cross-sectional study was conducted on 421 healthcare providers in selected public hospitals, Addis Ababa, Ethiopia. The hospitals were selected using a lottery sampling method, and a systematic random method was used to enroll participants. A structured self-administered instrument was used to gather information from participants. Data were checked for completeness and entered into Epi-Data software (version 3.1) and exported to SPSS software (version 25) for analysis. Descriptive statistics were used to describe participants' characteristics, and logistic regression, such as bivariate and multivariable analysis, were tested for associations. The level of significance was determined at a p-value of Results: In this study,periconceptional folic acid supplementation counseling practice wasfound in 51% of participants. Profession,salary, work load, patient flow, and assisted birth of a neonate with NTD were the factors associated with counseling practice (adjusted odds ratio [AOR]=3.215, 95% CI:1.085-9.523, AOR=0.213, 95% CI:0.95-0.487, AOR= 0.427 95% CI:0.213-0.859, AOR=0.223, 95% CI: 0.1-0.498, and AOR=15.107 95% CI:8.157-27.979, respectively).Conclusion: Health care providers demonstrated a good level of knowledge and counseling practice about the folic acid supplement in this study. Medical doctor, salary, workload, patient flow, assisted birth of a neonate with NTD were found predictors for counseling practice.
{"title":"Counseling Practice towards Folic Acid use among Health Care Provider’s in Selected Public Hospitals in Addis Ababa, Ethiopia","authors":"Fetlework Aneteneh, E. Sendo, T. Gebretensaye","doi":"10.22038/IJN.2021.52183.1930","DOIUrl":"https://doi.org/10.22038/IJN.2021.52183.1930","url":null,"abstract":"Background: Periconceptional folic acid supplementation is an effective way to prevent neural tube defects (NTDs) and other congenital anomalies. It is shown that 9.7% of healthcare providers practiced periconceptional folic acid supplements in Ethiopia. Fewer than 50% of women receive information on folic acid before or only during pregnancy. This study was conducted to assess folic acid supplementation counseling practices among health care providers.Methods: This institution-based cross-sectional study was conducted on 421 healthcare providers in selected public hospitals, Addis Ababa, Ethiopia. The hospitals were selected using a lottery sampling method, and a systematic random method was used to enroll participants. A structured self-administered instrument was used to gather information from participants. Data were checked for completeness and entered into Epi-Data software (version 3.1) and exported to SPSS software (version 25) for analysis. Descriptive statistics were used to describe participants' characteristics, and logistic regression, such as bivariate and multivariable analysis, were tested for associations. The level of significance was determined at a p-value of Results: In this study,periconceptional folic acid supplementation counseling practice wasfound in 51% of participants. Profession,salary, work load, patient flow, and assisted birth of a neonate with NTD were the factors associated with counseling practice (adjusted odds ratio [AOR]=3.215, 95% CI:1.085-9.523, AOR=0.213, 95% CI:0.95-0.487, AOR= 0.427 95% CI:0.213-0.859, AOR=0.223, 95% CI: 0.1-0.498, and AOR=15.107 95% CI:8.157-27.979, respectively).Conclusion: Health care providers demonstrated a good level of knowledge and counseling practice about the folic acid supplement in this study. Medical doctor, salary, workload, patient flow, assisted birth of a neonate with NTD were found predictors for counseling practice.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"205 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85578324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22038/IJN.2021.50304.1880
W. Hanafi, W. Ibrahim, Noran Hashim
Background Neonatal jaundice may lead to a severe level if it is not well monitored. The long-term consequences of severe neonatal jaundice may result in devastating neurologic sequelae, including bilirubin encephalopathy and kernicterus. Exchange transfusion has remained the most effective modality for lowering serum bilirubin concentration. The present study aimed to determine the proportion and factors associated with exchange transfusion procedure among neonates with severe jaundice in Kelantan from 2015 to 2017.Methods This cross-sectional study was carried out among neonates with severe jaundice in Kelantan between 2015 and 2017 using jaundice surveillance data from Kelantan Health State Department.Result Out of the study subjects, 45 (19.7%) neonates had severe jaundice requiring an exchange transfusion procedure. From 2015 to 2017, the prevalence of severe neonatal jaundice requiring exchange transfusion raised from 17.0%-23.7%. The significant factors associated with exchange transfusion were neonatal infection, low birth weight, ABO blood group incompatibility, and maternal blood type O.Conclusion As evidenced by the obtained results, exchange transfusion among severe neonatal jaundice in Kelantan followed an increasing trend within the study period. Associated factors leading to exchange transfusion among severe neonatal jaundice were neonatal infection, low birth weight, ABO incompatibility, and maternal blood type O. The recognition of these factors would be of great help in developing effective strategies aimed at the prevention of exchange transfusion procedure and its subsequent complications.
{"title":"Factors Associated with Exchange Transfusion among Severe Neonatal Jaundice in Malaysia","authors":"W. Hanafi, W. Ibrahim, Noran Hashim","doi":"10.22038/IJN.2021.50304.1880","DOIUrl":"https://doi.org/10.22038/IJN.2021.50304.1880","url":null,"abstract":"Background Neonatal jaundice may lead to a severe level if it is not well monitored. The long-term consequences of severe neonatal jaundice may result in devastating neurologic sequelae, including bilirubin encephalopathy and kernicterus. Exchange transfusion has remained the most effective modality for lowering serum bilirubin concentration. The present study aimed to determine the proportion and factors associated with exchange transfusion procedure among neonates with severe jaundice in Kelantan from 2015 to 2017.Methods This cross-sectional study was carried out among neonates with severe jaundice in Kelantan between 2015 and 2017 using jaundice surveillance data from Kelantan Health State Department.Result Out of the study subjects, 45 (19.7%) neonates had severe jaundice requiring an exchange transfusion procedure. From 2015 to 2017, the prevalence of severe neonatal jaundice requiring exchange transfusion raised from 17.0%-23.7%. The significant factors associated with exchange transfusion were neonatal infection, low birth weight, ABO blood group incompatibility, and maternal blood type O.Conclusion As evidenced by the obtained results, exchange transfusion among severe neonatal jaundice in Kelantan followed an increasing trend within the study period. Associated factors leading to exchange transfusion among severe neonatal jaundice were neonatal infection, low birth weight, ABO incompatibility, and maternal blood type O. The recognition of these factors would be of great help in developing effective strategies aimed at the prevention of exchange transfusion procedure and its subsequent complications.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"696 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85388534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22038/IJN.2021.52504.1940
Behzad Barekatian, R. Kelishadi, Farinaz Sohrabi, M. Yazdi
Background: Infantile colic (IC) (a frequent reason for infantile referral to pediatricians) is a common indiscoverable problem posing concerns for parents. Varieties of theories for the etiology of IC have been raised, and different therapeutic approaches have been recommended in this regard. This study aimed to assess and compare the efficiency of dimethicone versus symbiotic in the treatment of IC. Methods: This randomized clinical trial was conducted on 149 infants with the diagnosis of IC based on the Wessel criteria from 2017 to 2018. The study population was randomly divided into two groups of Dimethicone (n=73) (five drops of dimethicone, three times a day for three weeks) and Symbiotic (n=76) (five daily drops of symbiotic for three weeks). Utilized symbiotic contained fructooligosacharide periodic and probiotic of 109CFU of Bifidobacterium lactis. Duration of an infant crying per day, numbers of crying per day, sleep duration per day, and number of defecation per day were obtained prior to the study and at the end of each week. Results: There was no statistically significant difference between the groups regarding age, gender, and values of breastfeeding (P>0.05). Crying duration, numbers of crying, and sleep duration per day improved significantly in the dimethicone group (P 0.05). Conclusion: The findings of the current study presented that dimethicone and symbiotic could successfully improve IC symptoms regarding crying times, as well as the duration and sleeping time per day. Comparison of these two remedies for IC treatment revealed no significant differences.
{"title":"Efficiency of Dimethicone and Symbiotic Approaches in Infantile Colic Management","authors":"Behzad Barekatian, R. Kelishadi, Farinaz Sohrabi, M. Yazdi","doi":"10.22038/IJN.2021.52504.1940","DOIUrl":"https://doi.org/10.22038/IJN.2021.52504.1940","url":null,"abstract":"Background: Infantile colic (IC) (a frequent reason for infantile referral to pediatricians) is a common indiscoverable problem posing concerns for parents. Varieties of theories for the etiology of IC have been raised, and different therapeutic approaches have been recommended in this regard. This study aimed to assess and compare the efficiency of dimethicone versus symbiotic in the treatment of IC. \u0000Methods: This randomized clinical trial was conducted on 149 infants with the diagnosis of IC based on the Wessel criteria from 2017 to 2018. The study population was randomly divided into two groups of Dimethicone (n=73) (five drops of dimethicone, three times a day for three weeks) and Symbiotic (n=76) (five daily drops of symbiotic for three weeks). Utilized symbiotic contained fructooligosacharide periodic and probiotic of 109CFU of Bifidobacterium lactis. Duration of an infant crying per day, numbers of crying per day, sleep duration per day, and number of defecation per day were obtained prior to the study and at the end of each week. \u0000Results: There was no statistically significant difference between the groups regarding age, gender, and values of breastfeeding (P>0.05). Crying duration, numbers of crying, and sleep duration per day improved significantly in the dimethicone group (P 0.05). \u0000Conclusion: The findings of the current study presented that dimethicone and symbiotic could successfully improve IC symptoms regarding crying times, as well as the duration and sleeping time per day. Comparison of these two remedies for IC treatment revealed no significant differences.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"31 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73099522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22038/IJN.2021.53275.1971
S. Tajalli, M. Fallahi, Maryam Bashardoust, M. Kazemian, Jamileh Heshmatpanah
Background: Despite the significant improvement in neonatal intensive care, neonatal death is still one of the most important challenges worldwide. Understanding the causes of neonatal mortality is important for health policymakers. This study aimed to assess neonatal mortality in an Iranian referral level Ш Neonatal Intensive Care Unit (NICU). Methods: This cross-sectional study was conducted on the neonates who were referred to a level Ш NICU between 2014 and 2019. Data collection was performed by the research assistants, using a pre-designed checklist from the neonatal medical records. All the neonatal records of the patients who died during the infancy period were collected. Data were analyzed using SPSS (version 23). Results: In total, 388 (12%) out of 3,078 inpatient neonates died In this study. The mean gestational age of neonates who died was 34.9 weeks and 53% of them were males. In addition, 92 (23%) of them died when they aged between 0-7 days and hyponatremia was the most common (30.9%) abnormal laboratory finding among them. The main causes of mortality included sepsis (26%), congenital multiple anomalies (21%), prematurity (20%), surgical procedures (15%), congenital heart disease (8%), inborn metabolic disorder (6%), hypoxic-ischemic encephalopathy (2.8%), and some unknown reasons (1.2 %), respectively. Sepsis, as the most common disorder in neonatal mortality among the patients, was detected in 74 (58.27%) preterm infants, and Acinetobacter was the main microbial detected pathogen. The rate of sepsis was significantly different in different gestational ages (P<0.001). Conclusion: Based on the obtained results, sepsis, prematurity, and congenital multiple anomalies are the most common causes of mortality among neonates. Causes of mortality during the first month of life were different indicating the need for evidence-based interventions and proper policymaking in the field of neonatal health.
{"title":"Neonatal Mortality in an Iranian Referral Level Ш Neonatal Intensive Care Unit: A Cross-Sectional Study","authors":"S. Tajalli, M. Fallahi, Maryam Bashardoust, M. Kazemian, Jamileh Heshmatpanah","doi":"10.22038/IJN.2021.53275.1971","DOIUrl":"https://doi.org/10.22038/IJN.2021.53275.1971","url":null,"abstract":"Background: Despite the significant improvement in neonatal intensive care, neonatal death is still one of the most important challenges worldwide. Understanding the causes of neonatal mortality is important for health policymakers. \u0000This study aimed to assess neonatal mortality in an Iranian referral level Ш Neonatal Intensive Care Unit (NICU). \u0000Methods: This cross-sectional study was conducted on the neonates who were referred to a level Ш NICU between 2014 and 2019. Data collection was performed by the research assistants, using a pre-designed checklist from the neonatal medical records. All the neonatal records of the patients who died during the infancy period were collected. Data were analyzed using SPSS (version 23). \u0000Results: In total, 388 (12%) out of 3,078 inpatient neonates died In this study. The mean gestational age of neonates who died was 34.9 weeks and 53% of them were males. In addition, 92 (23%) of them died when they aged between 0-7 days and hyponatremia was the most common (30.9%) abnormal laboratory finding among them. The main causes of mortality included sepsis (26%), congenital multiple anomalies (21%), prematurity (20%), surgical procedures (15%), congenital heart disease (8%), inborn metabolic disorder (6%), hypoxic-ischemic encephalopathy (2.8%), and some unknown reasons (1.2 %), respectively. Sepsis, as the most common disorder in neonatal mortality among the patients, was detected in 74 (58.27%) preterm infants, and Acinetobacter was the main microbial detected pathogen. The rate of sepsis was significantly different in different gestational ages (P<0.001). \u0000Conclusion: Based on the obtained results, sepsis, prematurity, and congenital multiple anomalies are the most common causes of mortality among neonates. Causes of mortality during the first month of life were different indicating the need for evidence-based interventions and proper policymaking in the field of neonatal health.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"28 1","pages":"68-75"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79698581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-25DOI: 10.22038/IJN.2021.52192.1932
J. Rompis, Darmawan Murdono, D. Daud, Rocky Wilar, M. Hatta, A. Umboh
Objective. Perinatal asphyxia is the main cause of neurodevelopmental sequelae and perinatal death. Caspase-3 is a major enzyme associated with apoptosis and is increased in hypoxic ischemic events. There is still no reliable bio marker to predict the severity and outcome of an asphyxial event. This study aimed to determine caspase-3 level and its role as an outcome predictor in perinatal asphyxia.Methods. This paired-group observational analytical cross-sectional study was conducted between September 2016 and February 2017. Fifty neonates were included and Caspase-3 levels were examined at two different times. Student T-test and logistic regression analysis were used for statistical analysis.Results. There were 23 neonates (46%) with HIE and an increase in Caspase-3 level by 0.3135 points between first and second examination (t=6.555; P<0.0001). This study showed significant correlation between caspase-3 level and mortality in neonates with HIE both during initial (RR=2.33; P=0.014) and subsequent examinations (RR=2.25; P=0.015).Conclusions. There is a significant increase in Caspase-3 levels in infants who suffered from perinatal asphyxia and it can predict mortality in neonates with HIE.
目标。围产期窒息是神经发育后遗症和围产期死亡的主要原因。Caspase-3是一种与细胞凋亡相关的主要酶，在缺氧缺血性事件中增加。目前还没有可靠的生物标志物来预测窒息事件的严重程度和结果。本研究旨在确定caspase-3水平及其在围产期窒息预后预测中的作用。这项配对组观察性分析横断面研究于2016年9月至2017年2月进行。纳入50例新生儿，在两个不同时间检测Caspase-3水平。采用学生t检验和logistic回归分析进行统计分析。新生儿HIE 23例(46%)，第一次与第二次检查时Caspase-3水平升高0.3135点(t=6.555;P < 0.0001)。本研究显示新生儿新生儿HIE初始阶段caspase-3水平与死亡率有显著相关性(RR=2.33;P=0.014)及后续检查(RR=2.25;.Conclusions P = 0.015)。围产期窒息患儿Caspase-3水平显著升高，可预测新生儿HIE死亡率。
{"title":"The Role of Caspase-3 Level in Perinatal Asphyxia","authors":"J. Rompis, Darmawan Murdono, D. Daud, Rocky Wilar, M. Hatta, A. Umboh","doi":"10.22038/IJN.2021.52192.1932","DOIUrl":"https://doi.org/10.22038/IJN.2021.52192.1932","url":null,"abstract":"Objective. Perinatal asphyxia is the main cause of neurodevelopmental sequelae and perinatal death. Caspase-3 is a major enzyme associated with apoptosis and is increased in hypoxic ischemic events. There is still no reliable bio marker to predict the severity and outcome of an asphyxial event. This study aimed to determine caspase-3 level and its role as an outcome predictor in perinatal asphyxia.Methods. This paired-group observational analytical cross-sectional study was conducted between September 2016 and February 2017. Fifty neonates were included and Caspase-3 levels were examined at two different times. Student T-test and logistic regression analysis were used for statistical analysis.Results. There were 23 neonates (46%) with HIE and an increase in Caspase-3 level by 0.3135 points between first and second examination (t=6.555; P<0.0001). This study showed significant correlation between caspase-3 level and mortality in neonates with HIE both during initial (RR=2.33; P=0.014) and subsequent examinations (RR=2.25; P=0.015).Conclusions. There is a significant increase in Caspase-3 levels in infants who suffered from perinatal asphyxia and it can predict mortality in neonates with HIE.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86129396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-25DOI: 10.22038/IJN.2021.52137.1928
Fatemehsoltan Zegheibizadeh, Hasan Mottaghi Moghaddam, Sina Afzoon, H. Kianifar, Zahra Abbasi
Background: Congenital heart defect is one of the main causes of neonatal death. Although the majority of CHD occur in isolation, a significant number of them associate with noncardiac anomalies. Esophageal Atresia (EA)/ Tracheoesophageal Fistula (TEF) is the most common birth defect of the upper gastrointestinal tract. It is estimated that up to 70% of EA/TEF infants have a second another associated congenital anomaly, such as congenital heart disease. This study determined the proportion of cardiac anomalies among upper gastrointestinal (GI) system malformations in Mashhad Imam Reza Hospital.Method: In this retrospective study, records of 38 infants and children with upper GI obstructive disorders were evaluated who referred to Mashhad Imam Reza hospital pediatric heart clinic between 2001 and 2017. Data were entered SPSS version 16 and were analyzed using techniques such as chi-square and T-test.Results: Total of 38 babies with upper G.I. obstructive disorders (20 patients were female, 52.6%), and the mean of birth weight was 2.390 +-0.870 gr. Parents were relative (third-degree or more in 13 patients (34.2%), and 25 patients were nonrelative. Different labeled with the final diagnosis in 4 pt (36.8%) and 24 pt (63.3%), the primary and final diagnosis was the same. Normal echocardiographic findings in 3 pt (7.9%) and abnormal echocardiographic findings in 35 pt (92.1%), 19 pt(50%) had major important C.H.D. and 16 pt (42.1%) had little important C.H.D. Conclusions: The Cardiac defect is the most common associated anomaly in children with EA/TEF, which is divided into two subgroups. The first is an important major CHD that is effective in their gastric surgery and management, and VSD is the most common type of them. The other group is a less important CHD that is not effective in their management.And these patients are at risk for low birth weight and preterm labor
{"title":"Congenital Heart Defects in Children with Upper Gastrointestinal Anomalies","authors":"Fatemehsoltan Zegheibizadeh, Hasan Mottaghi Moghaddam, Sina Afzoon, H. Kianifar, Zahra Abbasi","doi":"10.22038/IJN.2021.52137.1928","DOIUrl":"https://doi.org/10.22038/IJN.2021.52137.1928","url":null,"abstract":"Background: Congenital heart defect is one of the main causes of neonatal death. Although the majority of CHD occur in isolation, a significant number of them associate with noncardiac anomalies. Esophageal Atresia (EA)/ Tracheoesophageal Fistula (TEF) is the most common birth defect of the upper gastrointestinal tract. It is estimated that up to 70% of EA/TEF infants have a second another associated congenital anomaly, such as congenital heart disease. This study determined the proportion of cardiac anomalies among upper gastrointestinal (GI) system malformations in Mashhad Imam Reza Hospital.Method: In this retrospective study, records of 38 infants and children with upper GI obstructive disorders were evaluated who referred to Mashhad Imam Reza hospital pediatric heart clinic between 2001 and 2017. Data were entered SPSS version 16 and were analyzed using techniques such as chi-square and T-test.Results: Total of 38 babies with upper G.I. obstructive disorders (20 patients were female, 52.6%), and the mean of birth weight was 2.390 +-0.870 gr. Parents were relative (third-degree or more in 13 patients (34.2%), and 25 patients were nonrelative. Different labeled with the final diagnosis in 4 pt (36.8%) and 24 pt (63.3%), the primary and final diagnosis was the same. Normal echocardiographic findings in 3 pt (7.9%) and abnormal echocardiographic findings in 35 pt (92.1%), 19 pt(50%) had major important C.H.D. and 16 pt (42.1%) had little important C.H.D. Conclusions: The Cardiac defect is the most common associated anomaly in children with EA/TEF, which is divided into two subgroups. The first is an important major CHD that is effective in their gastric surgery and management, and VSD is the most common type of them. The other group is a less important CHD that is not effective in their management.And these patients are at risk for low birth weight and preterm labor","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87070831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.22038/IJN.2021.53584.1981
Fadila, Faraz Omair, N. Kevlani
Hydronephrosis in a newborn in typically asymptomatic. It is one of the most common and usually benign anomalies detected on prenatal ultrasonography, with only a minority causing significant problem requiring urgent intervention. Grading systems are in place to classify hydronephrosis based on trimester and the antero-posterior diameter of the fetal renal pelvis. Albeit a cause for parental and physician anxiety, it is reassuring that most cases tend to be transient according to established literature, and may only require watchful waiting along with adequate follow up, the protocols for which are in place in most countries. Sometimes however, a large hydronephrosis could cause mass effect, pressing on the anatomically adjacent structures in the body, and could therefore present in ways not commonly thought of. We present a neonate with giant congenital hydronephrosis with feed intolerance resulting from duodenal obstruction. A brief description of the case is followed by a mini review.
{"title":"The Unusual Association of Congenital Hydronephrosis with Intestinal Obstruction In a Newborn","authors":"Fadila, Faraz Omair, N. Kevlani","doi":"10.22038/IJN.2021.53584.1981","DOIUrl":"https://doi.org/10.22038/IJN.2021.53584.1981","url":null,"abstract":"Hydronephrosis in a newborn in typically asymptomatic. It is one of the most common and usually benign anomalies detected on prenatal ultrasonography, with only a minority causing significant problem requiring urgent intervention. Grading systems are in place to classify hydronephrosis based on trimester and the antero-posterior diameter of the fetal renal pelvis. Albeit a cause for parental and physician anxiety, it is reassuring that most cases tend to be transient according to established literature, and may only require watchful waiting along with adequate follow up, the protocols for which are in place in most countries. Sometimes however, a large hydronephrosis could cause mass effect, pressing on the anatomically adjacent structures in the body, and could therefore present in ways not commonly thought of. We present a neonate with giant congenital hydronephrosis with feed intolerance resulting from duodenal obstruction. A brief description of the case is followed by a mini review.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76804354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.22038/IJN.2021.43684.1727
N. Khalesi, Farnoosh Seirafianpour, R. Hoseini, H. Otukesh, N. Rahimzadeh, S. Nakhaie, G. Gohardehi, P. Mohaghegh
Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates. Serum creatinine is the most commonly used marker of GFR; nevertheless, it has some limitations since it can be affected by factors other than renal function. Cystatin C, another endogenous marker used to estimate GFR, is not affected by non-renal factors. The results of some studies suggest that serum cystatin C levels are more accurate tests of kidney function than serum creatinine levels. This study aimed to estimate GFR with cystatin C-based formulas among neonates and determine the correlations between these methods and the Schwartz formula. Methods: The population of this research consisted of 99 neonates whose serum creatinine and cystatin C levels were measured concurrently. Moreover, the glomerular filtration rate was estimated using the Schwartz formula and 14 cystatin C-based formulas separately. Results: Based on the findings, all GFR values based on cystatin C formulas correlated significantly with each other (p 0.05). The only cystatin C formula that yielded values correlating with the Schwartz formula was CysCrEq, which used serum cystatin C and creatinine concomitantly. Conclusion: It can be concluded that since all GFR values based on cystatin C correlated significantly and cystatin Cwasindependent of non-renal factors, cystatin C reflected the real GFR more accurately than serum creatinine. Nonetheless, further studies with gold standard techniques are required to verify the usefulness of cystatin C-based formulas.
{"title":"Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates","authors":"N. Khalesi, Farnoosh Seirafianpour, R. Hoseini, H. Otukesh, N. Rahimzadeh, S. Nakhaie, G. Gohardehi, P. Mohaghegh","doi":"10.22038/IJN.2021.43684.1727","DOIUrl":"https://doi.org/10.22038/IJN.2021.43684.1727","url":null,"abstract":"Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates. Serum creatinine is the most commonly used marker of GFR; nevertheless, it has some limitations since it can be affected by factors other than renal function. Cystatin C, another endogenous marker used to estimate GFR, is not affected by non-renal factors. The results of some studies suggest that serum cystatin C levels are more accurate tests of kidney function than serum creatinine levels. This study aimed to estimate GFR with cystatin C-based formulas among neonates and determine the correlations between these methods and the Schwartz formula. Methods: The population of this research consisted of 99 neonates whose serum creatinine and cystatin C levels were measured concurrently. Moreover, the glomerular filtration rate was estimated using the Schwartz formula and 14 cystatin C-based formulas separately. Results: Based on the findings, all GFR values based on cystatin C formulas correlated significantly with each other (p 0.05). The only cystatin C formula that yielded values correlating with the Schwartz formula was CysCrEq, which used serum cystatin C and creatinine concomitantly. Conclusion: It can be concluded that since all GFR values based on cystatin C correlated significantly and cystatin Cwasindependent of non-renal factors, cystatin C reflected the real GFR more accurately than serum creatinine. Nonetheless, further studies with gold standard techniques are required to verify the usefulness of cystatin C-based formulas.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"14 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75012066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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