Pub Date : 2020-10-01DOI: 10.22038/IJN.2020.44225.1732
Hasan Birjandi, M. Maleki, Hosein Akhavan
Background: Neonatal rupture of the chordae of the tricuspid valve with severe regurgitation is scarce and devastating.Case report: Here, we report the case of a full-term male neonate presented with cyanosis caused by severe tricuspid regurgitation due to anterior leaflet papillary muscle rupture. Following initial stabilization by the infusion of prostaglandins E1, successful early repair was achieved.Conclusion: Early diagnosis of the tricuspid valve papillary muscle rupture is critical, and early surgical repair have a good result during early post-operative period.
{"title":"Successful Repair of Neonatal Tricuspid Regurgitation Due to Papillary Muscle Rupture: A Rare Case","authors":"Hasan Birjandi, M. Maleki, Hosein Akhavan","doi":"10.22038/IJN.2020.44225.1732","DOIUrl":"https://doi.org/10.22038/IJN.2020.44225.1732","url":null,"abstract":"Background: Neonatal rupture of the chordae of the tricuspid valve with severe regurgitation is scarce and devastating.Case report: Here, we report the case of a full-term male neonate presented with cyanosis caused by severe tricuspid regurgitation due to anterior leaflet papillary muscle rupture. Following initial stabilization by the infusion of prostaglandins E1, successful early repair was achieved.Conclusion: Early diagnosis of the tricuspid valve papillary muscle rupture is critical, and early surgical repair have a good result during early post-operative period.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"71 1","pages":"119-120"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86347463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-14DOI: 10.22038/IJN.2020.45886.1766
Mounica Kamineni, Tanvi Pai, Smitha D'Sa, K. Bhat
Dengue in pregnancy is associated with adverse maternal and fetal outcomes including perinatal transmission. We report a case of neonatal dengue in a baby born to a 29-year-old primigravida at 38 weeks gestation. She developed acute dengue fever two days prior to delivery. Her dengue NS 1 antigen was reactive. She delivered a term baby girl via spontaneous vaginal delivery.. Her fever persisted in the post-partum period; which was associated with post-partum hemorrhage, altered coagulation and liver function. She was clinically diagnosed to have HLH (Hemophagocytic lymphohistiocytosis), complicated with DIC (Disseminated Intravascular Coagulation); hence treated with IV dexamethasone, multiple blood products including FFP and platelet concentrate. She recovered in over the next 5 days. The baby girl was born with birth weight of 3040 grams, developed fever on day three of life with poor perfusion, associated with mottling and hypotension. Baby was treated with iv fluids, inotropes and supportive care. The fever subsided after 48 hours along with clinical improvement but continued to have thrombocytopenia. Baby did not have any bleeding. Platelet recovery started on 11th postnatal day (8th day of illness) and platelet count normalized at 2 weeks. Dengue serology IgM by ELISA was positive in both mother and baby. The clinical diagnosis was confirmed by laboratory tests. Dengue fever in mother very late in pregnancy can cause symptomatic dengue infection in the neonate.
{"title":"Acute Dengue fever in a Neonate Secondary to Perinatal Transmission","authors":"Mounica Kamineni, Tanvi Pai, Smitha D'Sa, K. Bhat","doi":"10.22038/IJN.2020.45886.1766","DOIUrl":"https://doi.org/10.22038/IJN.2020.45886.1766","url":null,"abstract":"Dengue in pregnancy is associated with adverse maternal and fetal outcomes including perinatal transmission. We report a case of neonatal dengue in a baby born to a 29-year-old primigravida at 38 weeks gestation. She developed acute dengue fever two days prior to delivery. Her dengue NS 1 antigen was reactive. She delivered a term baby girl via spontaneous vaginal delivery.. Her fever persisted in the post-partum period; which was associated with post-partum hemorrhage, altered coagulation and liver function. She was clinically diagnosed to have HLH (Hemophagocytic lymphohistiocytosis), complicated with DIC (Disseminated Intravascular Coagulation); hence treated with IV dexamethasone, multiple blood products including FFP and platelet concentrate. She recovered in over the next 5 days. The baby girl was born with birth weight of 3040 grams, developed fever on day three of life with poor perfusion, associated with mottling and hypotension. Baby was treated with iv fluids, inotropes and supportive care. The fever subsided after 48 hours along with clinical improvement but continued to have thrombocytopenia. Baby did not have any bleeding. Platelet recovery started on 11th postnatal day (8th day of illness) and platelet count normalized at 2 weeks. Dengue serology IgM by ELISA was positive in both mother and baby. The clinical diagnosis was confirmed by laboratory tests. Dengue fever in mother very late in pregnancy can cause symptomatic dengue infection in the neonate.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76730114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-03DOI: 10.22038/IJN.2020.43236.1718
Behzad Barekatain, Amirmohammad Armanian, Armindokht Shahsanaei, Marjan Shokrani
BackgroundRespiratory distress syndrome (RDS) is one of the major causes of morbidity and mortality in preterm infants. It’s severity and treatment affect the outcome of premature infants in neonatal intensive cares. Some studies have claimed that hypoalbuminemia and hypoproteinemia have an association with low outcome in preterm infants. In the current study, it is aimed to assess the association between serum total protein and albumin with the presentation of RDS among these group of newborns.MethodsIn the current cross-sectional study, 100 preterm neonates were assessed. This included a control group of 50 healthy neonates as well as a case group of 50 neonates diagnosed with RDS. Two milliliters of umbilical cord arterial blood sample was taken from each neonate, and laboratory indices, including total serum protein and albumin, were measured. Statistical analysis was conducted to compare identify potential variations between samples from healthy and RDS groups.ResultsNo statistical difference was detected between healthy and RDS affected preterm neonates regarding total protein (P-value=0.16) and serum albumin (P-value=0.27) levels. Total serum protein and albumin were not affected by the newborn's birth weight, and gender (P-value>0.05) among both healthy preterm neonates and the ones with RDS. However, significant association was detected with the gestational age (P-value
{"title":"Association of cord blood total protein and albumin levels with respiratory distress syndrome","authors":"Behzad Barekatain, Amirmohammad Armanian, Armindokht Shahsanaei, Marjan Shokrani","doi":"10.22038/IJN.2020.43236.1718","DOIUrl":"https://doi.org/10.22038/IJN.2020.43236.1718","url":null,"abstract":"BackgroundRespiratory distress syndrome (RDS) is one of the major causes of morbidity and mortality in preterm infants. It’s severity and treatment affect the outcome of premature infants in neonatal intensive cares. Some studies have claimed that hypoalbuminemia and hypoproteinemia have an association with low outcome in preterm infants. In the current study, it is aimed to assess the association between serum total protein and albumin with the presentation of RDS among these group of newborns.MethodsIn the current cross-sectional study, 100 preterm neonates were assessed. This included a control group of 50 healthy neonates as well as a case group of 50 neonates diagnosed with RDS. Two milliliters of umbilical cord arterial blood sample was taken from each neonate, and laboratory indices, including total serum protein and albumin, were measured. Statistical analysis was conducted to compare identify potential variations between samples from healthy and RDS groups.ResultsNo statistical difference was detected between healthy and RDS affected preterm neonates regarding total protein (P-value=0.16) and serum albumin (P-value=0.27) levels. Total serum protein and albumin were not affected by the newborn's birth weight, and gender (P-value>0.05) among both healthy preterm neonates and the ones with RDS. However, significant association was detected with the gestational age (P-value","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81485150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-03DOI: 10.22038/IJN.2020.47287.1810
S. Changizi-Ashtiyani, M. Asadi, S. Latifi
Background:Infantile colic is a common condition among infants, but its etiology is not fully identified. The purpose of this research was to detect and treat this complication by investigating the experiences of Iranian physicians. Methods:In this review study, the infantile colic was initially studied from the point of view of modern medicine. Electronic search in databases like Web of Science, Medline, Scopus, EBASE, Up-to-date; Magiran, SID, Irandoc, and the Google Scholar search engine were done. Then, this complication was investigated in the original references of Persian medicine. Results:The results of this research indicated that factors such as maternal mood during pregnancy, inappropriate maternal nutrition, gastrointestinal problems, and infantile cerebral problems are some of the causes that have been mentioned regarding infantile colic in modern and Persian medicine. Other causes such as spinal nerve stimulation, insomnia, and sleep apnea are also raised in Persian medicine. Almost all of these causes are due to poor digestion of milk and pnuma in the gastrointestinal tract. Iranian physicians have considered solutions such as massage with special oils, nutrition modification, and the use of hypnotics, etc. to reduce pnuma production in the gastrointestinal tract as well as its side effects. Applying all of these recommendations together can help better treat infantile colic. In the same study, scientific information derived from the works of traditional Persian medicine has been classified with the findings of modern medicine. Now, based on modern and traditional medicine, a new definition of colic has been proposed and a new treatment method for colic has been explained. Conclusion:Because the positive role of some measures such as massage and swaddling in modern medicine is confirmed, studying the recommendations of Persian medicine in the field of infantile colic seems to be able to compensate for the gap in identifying, preventing, and treating this complication.
背景:婴儿绞痛是一种常见的婴儿疾病，但其病因尚未完全确定。本研究的目的是通过调查伊朗医生的经验来发现和治疗这种并发症。方法:从现代医学的角度对小儿绞痛进行初步研究。Web of Science、Medline、Scopus、EBASE、updated等数据库的电子检索;Magiran, SID, Irandoc和Google Scholar搜索引擎完成了。然后，在波斯医学的原始参考文献中对这种并发症进行了调查。结果:本研究结果表明，产妇孕期情绪、产妇营养不良、胃肠问题和婴儿脑问题等因素是现代和波斯医学中提到的婴儿绞痛的一些原因。其他原因，如脊神经刺激、失眠和睡眠呼吸暂停也在波斯医学中提出。几乎所有这些原因都是由于牛奶消化不良和胃肠道脓肿。伊朗医生考虑了一些解决方案，如用特殊油按摩、营养修饰和使用催眠药等，以减少胃肠道中肺气瘤的产生及其副作用。综合运用所有这些建议可以帮助更好地治疗婴儿绞痛。在同一项研究中，来自传统波斯医学著作的科学信息已与现代医学的发现分类。现在，在现代医学和传统医学的基础上，提出了肠绞痛的新定义，并解释了肠绞痛的新治疗方法。结论:由于按摩、襁褓等措施在现代医学中的积极作用已被证实，研究波斯医学在婴儿绞痛领域的建议似乎可以弥补在识别、预防和治疗这一并发症方面的空白。
{"title":"Evaluation of the Causes of Infantile Colic in Persian Medicine","authors":"S. Changizi-Ashtiyani, M. Asadi, S. Latifi","doi":"10.22038/IJN.2020.47287.1810","DOIUrl":"https://doi.org/10.22038/IJN.2020.47287.1810","url":null,"abstract":"Background:Infantile colic is a common condition among infants, but its etiology is not fully identified. The purpose of this research was to detect and treat this complication by investigating the experiences of Iranian physicians. Methods:In this review study, the infantile colic was initially studied from the point of view of modern medicine. Electronic search in databases like Web of Science, Medline, Scopus, EBASE, Up-to-date; Magiran, SID, Irandoc, and the Google Scholar search engine were done. Then, this complication was investigated in the original references of Persian medicine. Results:The results of this research indicated that factors such as maternal mood during pregnancy, inappropriate maternal nutrition, gastrointestinal problems, and infantile cerebral problems are some of the causes that have been mentioned regarding infantile colic in modern and Persian medicine. Other causes such as spinal nerve stimulation, insomnia, and sleep apnea are also raised in Persian medicine. Almost all of these causes are due to poor digestion of milk and pnuma in the gastrointestinal tract. Iranian physicians have considered solutions such as massage with special oils, nutrition modification, and the use of hypnotics, etc. to reduce pnuma production in the gastrointestinal tract as well as its side effects. Applying all of these recommendations together can help better treat infantile colic. In the same study, scientific information derived from the works of traditional Persian medicine has been classified with the findings of modern medicine. Now, based on modern and traditional medicine, a new definition of colic has been proposed and a new treatment method for colic has been explained. Conclusion:Because the positive role of some measures such as massage and swaddling in modern medicine is confirmed, studying the recommendations of Persian medicine in the field of infantile colic seems to be able to compensate for the gap in identifying, preventing, and treating this complication.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83928147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-03DOI: 10.22038/IJN.2020.46789.1792
Y. Ghandi, S. Mehrabi, S. Alinejad
Background: An arrest in normal endomyocardial embryogenesis results in ventricular non - compaction which is a rare congenital cardiomyopathy. Non-compaction of the ventricular myocardium is a rare cardiomyopathy characterized by a pattern of prominent trabecular meshwork and deep inter-trabecular recesses. The clinical manifestation includes systolic and diastolic dysfunction, heart failure, ventricular arrhythmias and cardio embolic events.Case report: We describe neonate gestational diabetes mother (GDM) (38 weeks, weight of 2580 gr) with isolated right ventricular non-compaction and systolic and diastolic right heart dysfunction and according to meconium aspiration syndrome and complication with tension pneumothorax. Follow up after Six month showed total improving spontaneously. Conclusion: It is important to consider RVNC cardiomyopathy as a differential diagnosis cyanosis and respiratory distress at meconium aspiration syndrome in a neonate deliver from a GDM. Also despite RV cardiac dysfunction RVNC can tolerance complication such as pulmonary hypertension and tension pneumothorax, however with stand RV preload and afterload. At the end, RVNC in GMD could be improving spontaneously.
{"title":"Isolated Right Ventricular Non-compaction in a Neonate with Gestational Diabetes Mother: a case report","authors":"Y. Ghandi, S. Mehrabi, S. Alinejad","doi":"10.22038/IJN.2020.46789.1792","DOIUrl":"https://doi.org/10.22038/IJN.2020.46789.1792","url":null,"abstract":"Background: An arrest in normal endomyocardial embryogenesis results in ventricular non - compaction which is a rare congenital cardiomyopathy. Non-compaction of the ventricular myocardium is a rare cardiomyopathy characterized by a pattern of prominent trabecular meshwork and deep inter-trabecular recesses. The clinical manifestation includes systolic and diastolic dysfunction, heart failure, ventricular arrhythmias and cardio embolic events.Case report: We describe neonate gestational diabetes mother (GDM) (38 weeks, weight of 2580 gr) with isolated right ventricular non-compaction and systolic and diastolic right heart dysfunction and according to meconium aspiration syndrome and complication with tension pneumothorax. Follow up after Six month showed total improving spontaneously. Conclusion: It is important to consider RVNC cardiomyopathy as a differential diagnosis cyanosis and respiratory distress at meconium aspiration syndrome in a neonate deliver from a GDM. Also despite RV cardiac dysfunction RVNC can tolerance complication such as pulmonary hypertension and tension pneumothorax, however with stand RV preload and afterload. At the end, RVNC in GMD could be improving spontaneously.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85817413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22038/IJN.2020.47075.1804
Cüneyt Uğur, Abdulwaheed Adebola Yusuf
Background: This study aimed to determine the clinical characteristics of the newborns born in the hospital.Methods: This study included 1199 newborns born in Turkey Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia, Africa, in 2018. The gender, birth weight and height, delivery method, health status, mother's age, as well as gravida and parity conditions were retrospectively obtained from the records of the delivery clinic.Results: Out of 1199 newborns, 610 neonates were male (50.9%). The mean birth weight of the newborns was 2915.7±907.5 gr, and the mean birth height was 47.6±4.6 cm. Moreover, 66.6% of the newborns were born by normal vaginal delivery, and 91.8% were born alive. The mean age of the mothers was 26.3±5.4 years, and the mean values of gravida and parity were 3.8±2.5 and 2.9±2.1, respectively.Conclusion: There is a dearth of research regarding the evaluation of newborns in Somalia, Africa. Therefore, it is hoped that the results of this study will contribute to form standards for the follow-up of growth and development of infants living in this region and to improvematernal and child health.
{"title":"Evaluation of Newborns Born in a Training and Research Hospital in Mogadishu,Somalia, Africa","authors":"Cüneyt Uğur, Abdulwaheed Adebola Yusuf","doi":"10.22038/IJN.2020.47075.1804","DOIUrl":"https://doi.org/10.22038/IJN.2020.47075.1804","url":null,"abstract":"Background: This study aimed to determine the clinical characteristics of the newborns born in the hospital.Methods: This study included 1199 newborns born in Turkey Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia, Africa, in 2018. The gender, birth weight and height, delivery method, health status, mother's age, as well as gravida and parity conditions were retrospectively obtained from the records of the delivery clinic.Results: Out of 1199 newborns, 610 neonates were male (50.9%). The mean birth weight of the newborns was 2915.7±907.5 gr, and the mean birth height was 47.6±4.6 cm. Moreover, 66.6% of the newborns were born by normal vaginal delivery, and 91.8% were born alive. The mean age of the mothers was 26.3±5.4 years, and the mean values of gravida and parity were 3.8±2.5 and 2.9±2.1, respectively.Conclusion: There is a dearth of research regarding the evaluation of newborns in Somalia, Africa. Therefore, it is hoped that the results of this study will contribute to form standards for the follow-up of growth and development of infants living in this region and to improvematernal and child health.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"14 1","pages":"115-119"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75420296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22038/IJN.2020.44390.1735
S. Nobile, P. Marchionni, V. Carnielli
Background: The main definitions of bronchopulmonary dysplasia (BPD), proposed by Jobe-Bancalari, Shennan et al., and Walsh et al., focus on oxygen (O2)-need and ventilatory support for the first weeks of life and at 36 weeks of post-menstrual age (PMA). Oxygen need at 36 weeks of PMA is sometimes due to intercurrent episodes (IEs) other than BPD. The aim of this retrospective study was to characterize IEs and determine their impact on BPD in preterm infants born at 28 days and at 36 weeks of PMA (±10 days) was analyzed. We classified each infant according to the three BPD definitions. Patients requiring O2 or ventilator support at 36 weeks of PMA, with no need for O2 in the first 28 days of life, were qualified for having IEs if their O2/ventilator dependence (at 36 weeks) had a limited duration and/or could be ascribed to a known condition. Then, the contribution of IEs to the BPD rate was evaluated.Results: Out of 1,210 patients, the BPD infants were 431 (35.6%), 169 (14.0%), and 186 (15.4%) according to Jobe-Bancalari, Shennan et al., and Walsh et al., respectively. Twenty-eight patients had IEs (16.6% of those on O2 at 36 weeks of PMA) indicating a mild BPD overestimation (P=0.065).Conclusion: We proposed a definition of IEs and found that IEs could lead to a potential BPD overestimation. Further research is needed to find out if patients with IE, similarly to infants with BPD, are prone to childhood complications and need preventive measures.
背景:由Jobe-Bancalari、Shennan等人和Walsh等人提出的支气管肺发育不良(BPD)的主要定义侧重于生命最初几周和经后年龄(PMA) 36周时的氧气(O2)需求和通气支持。PMA 36周时的氧气需求有时是由于合并发作(IEs)而非BPD。本回顾性研究的目的是分析出生在28天和36周(±10天)的早产儿的IEs特征并确定其对BPD的影响。我们根据三种BPD定义对每个婴儿进行分类。在PMA 36周时需要氧气或呼吸机支持的患者，在生命的前28天不需要氧气，如果他们的氧气/呼吸机依赖(36周)持续时间有限和/或可以归因于已知的疾病，则有资格获得IEs。然后，评估IEs对BPD率的贡献。结果:根据Jobe-Bancalari、Shennan et al和Walsh et al的数据，1210例患者中，BPD患儿分别为431例(35.6%)、169例(14.0%)和186例(15.4%)。28例患者有IEs(占36周PMA时O2患者的16.6%)，表明轻度BPD高估(P=0.065)。结论:我们提出了IEs的定义，并发现IEs可能导致潜在的BPD高估。需要进一步的研究来确定IE患者是否与BPD婴儿相似，容易出现儿童期并发症并需要采取预防措施。
{"title":"Refining the Definition of BPD: Characterization of Intercurrent Episodes","authors":"S. Nobile, P. Marchionni, V. Carnielli","doi":"10.22038/IJN.2020.44390.1735","DOIUrl":"https://doi.org/10.22038/IJN.2020.44390.1735","url":null,"abstract":"Background: The main definitions of bronchopulmonary dysplasia (BPD), proposed by Jobe-Bancalari, Shennan et al., and Walsh et al., focus on oxygen (O2)-need and ventilatory support for the first weeks of life and at 36 weeks of post-menstrual age (PMA). Oxygen need at 36 weeks of PMA is sometimes due to intercurrent episodes (IEs) other than BPD. The aim of this retrospective study was to characterize IEs and determine their impact on BPD in preterm infants born at 28 days and at 36 weeks of PMA (±10 days) was analyzed. We classified each infant according to the three BPD definitions. Patients requiring O2 or ventilator support at 36 weeks of PMA, with no need for O2 in the first 28 days of life, were qualified for having IEs if their O2/ventilator dependence (at 36 weeks) had a limited duration and/or could be ascribed to a known condition. Then, the contribution of IEs to the BPD rate was evaluated.Results: Out of 1,210 patients, the BPD infants were 431 (35.6%), 169 (14.0%), and 186 (15.4%) according to Jobe-Bancalari, Shennan et al., and Walsh et al., respectively. Twenty-eight patients had IEs (16.6% of those on O2 at 36 weeks of PMA) indicating a mild BPD overestimation (P=0.065).Conclusion: We proposed a definition of IEs and found that IEs could lead to a potential BPD overestimation. Further research is needed to find out if patients with IE, similarly to infants with BPD, are prone to childhood complications and need preventive measures.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"57 1","pages":"100-103"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79616270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22038/IJN.2020.46170.1777
Milad Dolatkhah, S. Noori, R. Khavari-nejad, M. R. Farzami
Background: Pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (free β-hCG) as valuable biochemical biomarkers are used to screen down syndrome, Edwards syndrome, and Patau syndrome in the first trimester of pregnancy. Closed immunoassay analyzers are regarded as sophisticated platforms to measure biochemical biomarkers. This study compared the performance of three chemiluminescence analyzers when used for combined screening.Methods: The present cross-sectional study was conducted on 371 pregnant women within the age range of 20-47 years during 11+0 to 13+6 weeks of pregnancy referring to Dena laboratory in Tehran, Iran, during July 2018 and August 2018 using random selection. The biochemical biomarkers of PAPP-A and free β-hCG were assayed on Cobas, Immulite, and Maglumi analyzers. Benetech software as a commercial screening software was used to calculate the risks of trisomy 21 (T21), trisomy 18 (T18), and trisomy 13 (T13). Deming regression, nonparametric spearman analysis, analysis of variance, and Chi-square test were performed to analyze the data.Results: For the screening population, although the three systems well correlated to PAPP-A and free β-hCG, the values of Maglumi were slightly higher than those reported for Cobas and Immulite. The multiples of the median (MoM) of PAPP-A and free β-hCG had a significant correlation on three platforms. There were no significant differences between the calculated risks of T21, T18, and T13 on the three systems. The sensitivity for all systems was reported as 50%. In addition, specificity and negative predictive value (NPV) were higher than 99% and 95%, respectively. Positive predictive value (PPV) was reported as less than 50%.Conclusion: The obtained results of the present study demonstrated that there were significant correlations between three different systems in terms of PAPP-A and free β-hCG values and MoMs. The sensitivity of all systems for all trisomies was 50%; however, the specificity of all systems was almost the same. The best PPV and NPV for T21 were on Cobas, Immulite, and Maglumi, respectively. The PPV and NPV of all systems for T18/13 were almost the same.
{"title":"First-trimester Combined Screening for Trisomies 21, 18, and 13 by Three Closed Chemiluminescence Immunoassay Analyzers (an Experiment on Iranian Pregnant Women)","authors":"Milad Dolatkhah, S. Noori, R. Khavari-nejad, M. R. Farzami","doi":"10.22038/IJN.2020.46170.1777","DOIUrl":"https://doi.org/10.22038/IJN.2020.46170.1777","url":null,"abstract":"Background: Pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (free β-hCG) as valuable biochemical biomarkers are used to screen down syndrome, Edwards syndrome, and Patau syndrome in the first trimester of pregnancy. Closed immunoassay analyzers are regarded as sophisticated platforms to measure biochemical biomarkers. This study compared the performance of three chemiluminescence analyzers when used for combined screening.Methods: The present cross-sectional study was conducted on 371 pregnant women within the age range of 20-47 years during 11+0 to 13+6 weeks of pregnancy referring to Dena laboratory in Tehran, Iran, during July 2018 and August 2018 using random selection. The biochemical biomarkers of PAPP-A and free β-hCG were assayed on Cobas, Immulite, and Maglumi analyzers. Benetech software as a commercial screening software was used to calculate the risks of trisomy 21 (T21), trisomy 18 (T18), and trisomy 13 (T13). Deming regression, nonparametric spearman analysis, analysis of variance, and Chi-square test were performed to analyze the data.Results: For the screening population, although the three systems well correlated to PAPP-A and free β-hCG, the values of Maglumi were slightly higher than those reported for Cobas and Immulite. The multiples of the median (MoM) of PAPP-A and free β-hCG had a significant correlation on three platforms. There were no significant differences between the calculated risks of T21, T18, and T13 on the three systems. The sensitivity for all systems was reported as 50%. In addition, specificity and negative predictive value (NPV) were higher than 99% and 95%, respectively. Positive predictive value (PPV) was reported as less than 50%.Conclusion: The obtained results of the present study demonstrated that there were significant correlations between three different systems in terms of PAPP-A and free β-hCG values and MoMs. The sensitivity of all systems for all trisomies was 50%; however, the specificity of all systems was almost the same. The best PPV and NPV for T21 were on Cobas, Immulite, and Maglumi, respectively. The PPV and NPV of all systems for T18/13 were almost the same.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"15 1","pages":"71-79"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78170474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22038/IJN.2020.42355.1703
Z. Eskandari, N. Seyedfatemi, H. Haghani, A. Almasi-Hashiani, P. Mohagheghi
Background: The aim of this study was to investigate the effect of bedding preterm infants in nests on their motor behaviors in a neonatal intensive care unit (NICU) in Iran.Methods: In this randomized controlled trial, 44 clinically stable preterm infants, admitted to the NICU, were recruited and randomly divided into two groups of control and intervention. The routine of the unit was to take care of infants on a flat mattress. The intervention was a U-shaped cloth nest in which the intervention group was bedded for 7 days. The control group consisted of infants who were normally cared without any boundaries. All infants were videotaped before and on the last day of the intervention. The motor behaviors, as defined in the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) sheet, were analyzed in each of the films.Results: To compare the number of total extensor motor behaviors between the two groups, the change score in each group was calculated and compared between the two groups. The mean change scores in the intervention and control groups were -21.36±13.5 and 2.32±7.9, respectively. Accordingly, nesting significantly reduced the occurrence of unstable behaviors in the intervention group, compared to that in the control group (P<0.001).Conclusion: According to the findings, supporting the preterm infant body even by accessible materials could enhance their neurodevelopmental strengths and motor behavior stabilities.
{"title":"Effect of Nesting on Extensor Motor Behaviors in Preterm Infants: A Randomized Clinical Trial","authors":"Z. Eskandari, N. Seyedfatemi, H. Haghani, A. Almasi-Hashiani, P. Mohagheghi","doi":"10.22038/IJN.2020.42355.1703","DOIUrl":"https://doi.org/10.22038/IJN.2020.42355.1703","url":null,"abstract":"Background: The aim of this study was to investigate the effect of bedding preterm infants in nests on their motor behaviors in a neonatal intensive care unit (NICU) in Iran.Methods: In this randomized controlled trial, 44 clinically stable preterm infants, admitted to the NICU, were recruited and randomly divided into two groups of control and intervention. The routine of the unit was to take care of infants on a flat mattress. The intervention was a U-shaped cloth nest in which the intervention group was bedded for 7 days. The control group consisted of infants who were normally cared without any boundaries. All infants were videotaped before and on the last day of the intervention. The motor behaviors, as defined in the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) sheet, were analyzed in each of the films.Results: To compare the number of total extensor motor behaviors between the two groups, the change score in each group was calculated and compared between the two groups. The mean change scores in the intervention and control groups were -21.36±13.5 and 2.32±7.9, respectively. Accordingly, nesting significantly reduced the occurrence of unstable behaviors in the intervention group, compared to that in the control group (P<0.001).Conclusion: According to the findings, supporting the preterm infant body even by accessible materials could enhance their neurodevelopmental strengths and motor behavior stabilities.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"183 1","pages":"64-70"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74687736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22038/IJN.2020.49154.1855
Mohammad Razmyar, A. Hamedi
Background: Herpes zoster occurs due to reactivation of varicella zoster-virus (VZV) that is latent in dorsal root ganglion cells after primary varicella infection. It can occur in any age but is very rare during infancy. Acquisition of this virus in utero or early after birth may result in infantile herpes zoster. Case report: Here, it is aimed to report an infant with herpes zoster whom his mother had developed varicella two years before pregnancy. Conclusion: Despite the rarity of shingles in infants after birth, any infant who has a vesicular lesion in a particular neurological dermatome should be aware of the disease.
{"title":"Varicella Zoster Infection in Infancy (A Very Rare Case Report)","authors":"Mohammad Razmyar, A. Hamedi","doi":"10.22038/IJN.2020.49154.1855","DOIUrl":"https://doi.org/10.22038/IJN.2020.49154.1855","url":null,"abstract":"Background: Herpes zoster occurs due to reactivation of varicella zoster-virus (VZV) that is latent in dorsal root ganglion cells after primary varicella infection. It can occur in any age but is very rare during infancy. Acquisition of this virus in utero or early after birth may result in infantile herpes zoster. Case report: Here, it is aimed to report an infant with herpes zoster whom his mother had developed varicella two years before pregnancy. Conclusion: Despite the rarity of shingles in infants after birth, any infant who has a vesicular lesion in a particular neurological dermatome should be aware of the disease.","PeriodicalId":14584,"journal":{"name":"Iranian Journal of Neonatology IJN","volume":"12 1","pages":"126-127"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88264204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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