Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.299
Manabu Abe, K. Uno, Y. Koike, M. Tsugita, M. Tobita, K. Kajiwara, K. Toyama, H. Kawase, N. Yohkoh, Mayumi Sasahara, Miho Takahashi, K. Ono, Youko Sutoh, S. Maruyama, Kazuhiko Nagai
A questionnaire survey of patinets' views regarding pharmaceuticals was carried on 4264 drugadministered patients more than 16 years of age at 13 medical institutions, consisting 9 hospitals and 4 pharmacies in the suburbs of Niigata City.The results were as follows:1. The degree of patinet concern about pharmaceuticals was 33.7%(95% confidence interval 27.8-39.6). The score was significantly higher in young patients than in elderly patients (P<0.0001), in females than in males (P=0.0002), in inpatients than in outpatients (P< 0.0001) and in the 2 university hospitals than in the other 11 institutions (P< 0.0001).2. Regarding the information which the patients wanted to know about the pharmaceuticals, 53.1 % wanted to know about the “effects of the drugs”, 44.7% about the “adverse effects of the drugs”, 27.2% about “drug interactions” and 21.2% about “name of drugs” . Therefore, a high percentage of patients wanted to know about both the “effects of the drugs” and the “adverse effects of the drugs” .3. The degree of patient anxiety about any adverse effects of the drugs was 23.0%(95% confidence interval 19.7-26.3). This percentage was significantly higher in young patients than in aged patients (P< 0.0001), in females than in males (P<0.0001), in the 6 institutions providing no 300 drug information than in the 7 institutions providing drug information (P=0.0431) and in the 9hospitals than in the 4 pharmacies (P<0.0001).
{"title":"Survey on Patients' View of Pharmaceuticals in the Multiple Medical Institutions.","authors":"Manabu Abe, K. Uno, Y. Koike, M. Tsugita, M. Tobita, K. Kajiwara, K. Toyama, H. Kawase, N. Yohkoh, Mayumi Sasahara, Miho Takahashi, K. Ono, Youko Sutoh, S. Maruyama, Kazuhiko Nagai","doi":"10.5649/JJPHCS1975.25.299","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.299","url":null,"abstract":"A questionnaire survey of patinets' views regarding pharmaceuticals was carried on 4264 drugadministered patients more than 16 years of age at 13 medical institutions, consisting 9 hospitals and 4 pharmacies in the suburbs of Niigata City.The results were as follows:1. The degree of patinet concern about pharmaceuticals was 33.7%(95% confidence interval 27.8-39.6). The score was significantly higher in young patients than in elderly patients (P<0.0001), in females than in males (P=0.0002), in inpatients than in outpatients (P< 0.0001) and in the 2 university hospitals than in the other 11 institutions (P< 0.0001).2. Regarding the information which the patients wanted to know about the pharmaceuticals, 53.1 % wanted to know about the “effects of the drugs”, 44.7% about the “adverse effects of the drugs”, 27.2% about “drug interactions” and 21.2% about “name of drugs” . Therefore, a high percentage of patients wanted to know about both the “effects of the drugs” and the “adverse effects of the drugs” .3. The degree of patient anxiety about any adverse effects of the drugs was 23.0%(95% confidence interval 19.7-26.3). This percentage was significantly higher in young patients than in aged patients (P< 0.0001), in females than in males (P<0.0001), in the 6 institutions providing no 300 drug information than in the 7 institutions providing drug information (P=0.0431) and in the 9hospitals than in the 4 pharmacies (P<0.0001).","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"1 1","pages":"299-306"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88472897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/jjphcs1975.25.48
M. Moriyama, K. Furuno, S. Yamashita, H. Araki, S. Sanada, E. Oka, Y. Gomita
We conducted an anonymous questionnaire mail survey on patients, who had received medication instructions while hospitalized and were later discharged from the Department of Child Neurology from the first of October 1993 to the end of November 1995. The average age of the patients was 5.4 (0-21) years old, and the average frequency of medication instruction was 8.4 (1-46) times. The results of the overall evaluation from patients and/or their family to the medication instruction was “It was good” ; 92.3%, “Can not judge” ; 6.6%, and “It was bad” ; 1.1%, Moreover, it was “Necessary” ; 93.4%, “Not necessary” ; 1.1%, and “Can not judge” ; 5.5%. Regarding the question “Were the medication instructions sufficient?” “It was good” was 92.3% as an overall evaluation. Therefore, the medication instructions were generally considered to be good by the patients and/or their family. The results obtained from this survey were thus valuable in evaluating the medication instructions for child epilepsy patients.
{"title":"Medication Instruction for Child Patients with Epilepsy. (IV). Survey of Patient Consideration after Leaves Hospital.","authors":"M. Moriyama, K. Furuno, S. Yamashita, H. Araki, S. Sanada, E. Oka, Y. Gomita","doi":"10.5649/jjphcs1975.25.48","DOIUrl":"https://doi.org/10.5649/jjphcs1975.25.48","url":null,"abstract":"We conducted an anonymous questionnaire mail survey on patients, who had received medication instructions while hospitalized and were later discharged from the Department of Child Neurology from the first of October 1993 to the end of November 1995. The average age of the patients was 5.4 (0-21) years old, and the average frequency of medication instruction was 8.4 (1-46) times. The results of the overall evaluation from patients and/or their family to the medication instruction was “It was good” ; 92.3%, “Can not judge” ; 6.6%, and “It was bad” ; 1.1%, Moreover, it was “Necessary” ; 93.4%, “Not necessary” ; 1.1%, and “Can not judge” ; 5.5%. Regarding the question “Were the medication instructions sufficient?” “It was good” was 92.3% as an overall evaluation. Therefore, the medication instructions were generally considered to be good by the patients and/or their family. The results obtained from this survey were thus valuable in evaluating the medication instructions for child epilepsy patients.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"19 1","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85474583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.249
Takanori Miura, R. Kojima, Youji Sugiura, M. Mizutani, F. Takatsu, Yoshio Suzuki
It has recently been reported that therapeutic drug monitoring (TDM) plays an important role in the optimal individualization of drug dosage regimens. However, TDM is known to have some pitfalls including inappropriate blood sampling, and these pitfalls are considered to possibly result from a lack of TDM education by the medical staffs, especially doctors and nurses. In the present study, we thus tried to determine whether an improved knowledge about TDM by the medical staff would result in a better drug therapy (e.g. dosage design). The medical staff was thus taugth about TDM pharmacists regarding several points, including a blood sampling. After this TDM education, the incidence of a time difference between the enforcement time and the recording time of drug dripping and blood sampling significantly decreased. The incidence of inadequate blood sampling in outpatients was 90% before TDM education, while after such education, it was only 14.5%. TDM education improvements were observed in the dosage regimens, drug evaluation, and monitoring of side effect, drug interaction and compliance, and thus, effectiveness of drug therapy was a much higher, than that before TDM education. These results suggest that an improved educational program for TDM given by pharmacists for medical personnel may thus significantly improve the clinical effectiveness of drug therapy and also help to avoid errors drug administration.
{"title":"Effect of Educational Activity to the Medical Staffs on a Useful Application of Therapeutic Drug Monitoring.","authors":"Takanori Miura, R. Kojima, Youji Sugiura, M. Mizutani, F. Takatsu, Yoshio Suzuki","doi":"10.5649/JJPHCS1975.25.249","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.249","url":null,"abstract":"It has recently been reported that therapeutic drug monitoring (TDM) plays an important role in the optimal individualization of drug dosage regimens. However, TDM is known to have some pitfalls including inappropriate blood sampling, and these pitfalls are considered to possibly result from a lack of TDM education by the medical staffs, especially doctors and nurses. In the present study, we thus tried to determine whether an improved knowledge about TDM by the medical staff would result in a better drug therapy (e.g. dosage design). The medical staff was thus taugth about TDM pharmacists regarding several points, including a blood sampling. After this TDM education, the incidence of a time difference between the enforcement time and the recording time of drug dripping and blood sampling significantly decreased. The incidence of inadequate blood sampling in outpatients was 90% before TDM education, while after such education, it was only 14.5%. TDM education improvements were observed in the dosage regimens, drug evaluation, and monitoring of side effect, drug interaction and compliance, and thus, effectiveness of drug therapy was a much higher, than that before TDM education. These results suggest that an improved educational program for TDM given by pharmacists for medical personnel may thus significantly improve the clinical effectiveness of drug therapy and also help to avoid errors drug administration.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"15 1","pages":"249-256"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90688593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.532
Mikio Saito, K. Uno
{"title":"Study on the Index of the Propriety of the Adopted Medicine. The Selection Index Asked from the Use Quantity.","authors":"Mikio Saito, K. Uno","doi":"10.5649/JJPHCS1975.25.532","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.532","url":null,"abstract":"","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"102 1","pages":"532-539"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78176579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.511
Keiji Kuramoto, Kyoko Watanabe, T. Shoji, Y. Nakagawa
A study on the prevention of angialgia induced by the high osmotic pressure of Peripheral Parenteral Nutrition infusion: Influence on the infusion system using Tandem method.During peripheral parenteral nutrition (PPN) infusions, angialgia more frequently occures than during other types of peripheral infusion. This is probably caused by the low pH, infusion speed and high osmotic pressure of PPN. We hypothesized that we could prevent angialgia by attenuating the osmotic pressures during PPN infusion. We therefore attempted examinations using the Tandem method as follows; It was possible to control the osmotic pressure in the effuent solution by changing the joining method of these infusions, thus suggesting that the specific gravity of these infusions affected the osmotic pressure.Specifically, we connected a hypotonic infusions (e.q., Soldem-3 A) with a low specific gravity to a PPN infusion (e.q., Amicaliq) with a high specific gravity, and the osmotic pressure of the effluent solution was maintained at a high level during the first 15 min, but thereafter gradually decreased. On the other hand, We connected a PPN infusion to a hypotonic infusion, and thus were able to maintain a low and constant osmotic pressure in the effluent solution.These results suggest that the Tandem method is useful in preventing angialgia due to the high osmotic pressure of PPN infusion. PPN infusion should thus be connected to a hypotonic infusion that has a lower specific gravity than that of the PPN infusion.
{"title":"Ths Study on the Prevention of Angialgia induced by the High osmotic Pressure of Peripheral Parenteral Nutrition Infusions: Influence on the Infusion System Using Tandem Method.","authors":"Keiji Kuramoto, Kyoko Watanabe, T. Shoji, Y. Nakagawa","doi":"10.5649/JJPHCS1975.25.511","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.511","url":null,"abstract":"A study on the prevention of angialgia induced by the high osmotic pressure of Peripheral Parenteral Nutrition infusion: Influence on the infusion system using Tandem method.During peripheral parenteral nutrition (PPN) infusions, angialgia more frequently occures than during other types of peripheral infusion. This is probably caused by the low pH, infusion speed and high osmotic pressure of PPN. We hypothesized that we could prevent angialgia by attenuating the osmotic pressures during PPN infusion. We therefore attempted examinations using the Tandem method as follows; It was possible to control the osmotic pressure in the effuent solution by changing the joining method of these infusions, thus suggesting that the specific gravity of these infusions affected the osmotic pressure.Specifically, we connected a hypotonic infusions (e.q., Soldem-3 A) with a low specific gravity to a PPN infusion (e.q., Amicaliq) with a high specific gravity, and the osmotic pressure of the effluent solution was maintained at a high level during the first 15 min, but thereafter gradually decreased. On the other hand, We connected a PPN infusion to a hypotonic infusion, and thus were able to maintain a low and constant osmotic pressure in the effluent solution.These results suggest that the Tandem method is useful in preventing angialgia due to the high osmotic pressure of PPN infusion. PPN infusion should thus be connected to a hypotonic infusion that has a lower specific gravity than that of the PPN infusion.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"459 1","pages":"511-516"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76691266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.169
Y. Kurihara, K. Uesugi, M. Kayano, Yasuo Dohiguchi, Nobuyuki Fukayama
A simple and sensitive reversed-phase high-performance liquid chromatographic method was developed for the analysis of warfarin (WF) in both human serum and serum ultrafiltrate. WF and internal standard (I.S.) were extracted from the serum by simple deproteinization and filtration with a membrane filter. The Column-switching system utilized the short polymer-coated mixed-function (PCMF) phase deproteinization column coupled with a C18 semi-micro analytical column using a mobile phase of acetonitrile, water and NH4H2PO4, followed by a post-column photochemical reaction and fluorimetric detection. The extraction recovery was greater than 80% and the WF and I. S. were separated from the endogenous components in the serum and serumultrafiltrate. The calibration curve was linear from 5 to 1000 ng/mL of serum and 1 to 150 ng/ mL of the serum ultrafiltrate. The limit of quantification was 5 and 1 ng/mL for found to be the serum and serum ultrafiltrate, respectively. The inter and intra-day coefficients of variation for the serum and serum ultrafiltrate ranged less than 10%, respectively. WF was found to be the stable in the serum for a 4-month period during storage at -20°C.
{"title":"Determination of Warfarin in Human Serum and Serum Ultrafiltrate by Column-switching Liquid Chromatographic System Using a Semi-micro Bore Column.","authors":"Y. Kurihara, K. Uesugi, M. Kayano, Yasuo Dohiguchi, Nobuyuki Fukayama","doi":"10.5649/JJPHCS1975.25.169","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.169","url":null,"abstract":"A simple and sensitive reversed-phase high-performance liquid chromatographic method was developed for the analysis of warfarin (WF) in both human serum and serum ultrafiltrate. WF and internal standard (I.S.) were extracted from the serum by simple deproteinization and filtration with a membrane filter. The Column-switching system utilized the short polymer-coated mixed-function (PCMF) phase deproteinization column coupled with a C18 semi-micro analytical column using a mobile phase of acetonitrile, water and NH4H2PO4, followed by a post-column photochemical reaction and fluorimetric detection. The extraction recovery was greater than 80% and the WF and I. S. were separated from the endogenous components in the serum and serumultrafiltrate. The calibration curve was linear from 5 to 1000 ng/mL of serum and 1 to 150 ng/ mL of the serum ultrafiltrate. The limit of quantification was 5 and 1 ng/mL for found to be the serum and serum ultrafiltrate, respectively. The inter and intra-day coefficients of variation for the serum and serum ultrafiltrate ranged less than 10%, respectively. WF was found to be the stable in the serum for a 4-month period during storage at -20°C.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"2 2","pages":"169-175"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72630139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.621
R. Matsushita, Mariko Asahi, F. Ichimura, T. Hashimoto, E. Matsushita, S. Kaneko, Kenichi Kobayashi
jectable drug solutions with the contamination of HBV. However, there is still no experimental evidence of an infection by HBV blood cross contamination, except for epidemiological analyses. Moreover, the stability of HBV antigen and HBV-DNA contents in injectable drug solutions has not yet been analyzed. Therefore, the stability of HBV antigen and HBV-DNA in injectable drug solution (saline, heparin, 1% lidocaine, 1% heparin in saline) for 7 days under 4•Ž after dilution of HBe positive patients serum with each solution was investigated in this study. The HBe antigen and HBV-DNA contents showed no decrease for 7 days. Although the relationship between HBe antigen or HBV-DNA and infection ability, has yet to be elucidated, that drawing blood from an HBV carrier clearly requires extreme care.
{"title":"The Stability of Hepatitis B Virus Antigen and HBV-DNA Contents in Injectable Drug Solutions.","authors":"R. Matsushita, Mariko Asahi, F. Ichimura, T. Hashimoto, E. Matsushita, S. Kaneko, Kenichi Kobayashi","doi":"10.5649/JJPHCS1975.25.621","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.621","url":null,"abstract":"jectable drug solutions with the contamination of HBV. However, there is still no experimental evidence of an infection by HBV blood cross contamination, except for epidemiological analyses. Moreover, the stability of HBV antigen and HBV-DNA contents in injectable drug solutions has not yet been analyzed. Therefore, the stability of HBV antigen and HBV-DNA in injectable drug solution (saline, heparin, 1% lidocaine, 1% heparin in saline) for 7 days under 4•Ž after dilution of HBe positive patients serum with each solution was investigated in this study. The HBe antigen and HBV-DNA contents showed no decrease for 7 days. Although the relationship between HBe antigen or HBV-DNA and infection ability, has yet to be elucidated, that drawing blood from an HBV carrier clearly requires extreme care.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"396 2 1","pages":"621-626"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73151365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.347
H. Yoshida, T. Mikawa, Moemi Saito, M. Hoshi, M. Yamada, F. Kawai, Noriko Miwa, K. Edo
{"title":"Regulation of Hospital Pharmaceutical Manufacturing in Fukushima Medical University Hospital.","authors":"H. Yoshida, T. Mikawa, Moemi Saito, M. Hoshi, M. Yamada, F. Kawai, Noriko Miwa, K. Edo","doi":"10.5649/JJPHCS1975.25.347","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.347","url":null,"abstract":"","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"8 1","pages":"347-356"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85248015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.212
T. Itoh, T. Shiga, M. Inagaki, K. Fukushima
As a general hospital that is aiming to provide regional medical care, our hospital has been actively involved in trying to establish a unified system for providing information on drugs to patients, through close cooperation with the Regional Pharmacists Association. We have been involved in promoting the spread of prescriptions to be filled at outside phrmacies, training pharmacists working in pharmacies, and providing information on drugs to patients through the issuance of a “medicine guidebook” and “drug-record pocketbook”, and thus have established a system for exchanging of information on drugs in order to monitor the side effects in patients, and thereby establish a system to exchange information among patients treated at home. The results of our efforts in these areas have indicated that, hospital pharmacists, in cooperation with pharmacists working at pharmacies, can therefore partitively contribute to the treatment of outpatients and to regional medical care.
{"title":"Toward the Establishment of a Unified System for the Provision of Information on Drugs by Hospital Pharmacists to Pharmacists Working in Pharmacies.","authors":"T. Itoh, T. Shiga, M. Inagaki, K. Fukushima","doi":"10.5649/JJPHCS1975.25.212","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.212","url":null,"abstract":"As a general hospital that is aiming to provide regional medical care, our hospital has been actively involved in trying to establish a unified system for providing information on drugs to patients, through close cooperation with the Regional Pharmacists Association. We have been involved in promoting the spread of prescriptions to be filled at outside phrmacies, training pharmacists working in pharmacies, and providing information on drugs to patients through the issuance of a “medicine guidebook” and “drug-record pocketbook”, and thus have established a system for exchanging of information on drugs in order to monitor the side effects in patients, and thereby establish a system to exchange information among patients treated at home. The results of our efforts in these areas have indicated that, hospital pharmacists, in cooperation with pharmacists working at pharmacies, can therefore partitively contribute to the treatment of outpatients and to regional medical care.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"27 1","pages":"212-217"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72954185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.5649/JJPHCS1975.25.112
N. Morikawa, Teruaki Mori, K. Ikawa, H. Kawashima, M. Takeyama, S. Hori
We performed a clinical pharmacy based service on the therapeutic drug monitoring (TDM) of cyclophosphamide (CP) during high dose CP chemotherapy in order to mobilize the peripheral blood stem cell in a 42-year-old man with glioblastoma. The patient was infused with 2000 mg CP for 3.75 hours. Samples of blood and of cerebrospinal fluid (CSF) were obtained. Both the CP and active metabolite of CP, nor-mustard (NM), concentrations were measured by the colorimetric assay method used 4-(p-Nitrobenzyl) pyridine (NBP) and the phamacokinetic parameters of CP and NM in plasma and CSF were estimated used a compartment model. The plasma concentration of CP peaked at the end of infusion, and there after decreased in a bi-exponential decay manner. The CSF concentration of CP peaked at the end of infusion, and then decreased in a mono-exponential decay manner. The plasma concentration of NM peaked 2 hours after drug administration and then gradually decreased. NM was not detectable in CSF. The area under the concentration-time curve (AUC) for the CSF of CP comprised only about 16.7% of that found in plasma. Those results suggested that the cytotoxicity of CP and NM in CSF was low because of the permeability of CP and NM into CSF was low.
{"title":"Progressive Trial on Clinical Services in a Hospital(V). Pharmacokinetics of Cyclophosphamide in Plasma and Cerebrospinal Fluid during Mobilization of Blood Stem Cells by High Dose Chemotherapy.","authors":"N. Morikawa, Teruaki Mori, K. Ikawa, H. Kawashima, M. Takeyama, S. Hori","doi":"10.5649/JJPHCS1975.25.112","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.112","url":null,"abstract":"We performed a clinical pharmacy based service on the therapeutic drug monitoring (TDM) of cyclophosphamide (CP) during high dose CP chemotherapy in order to mobilize the peripheral blood stem cell in a 42-year-old man with glioblastoma. The patient was infused with 2000 mg CP for 3.75 hours. Samples of blood and of cerebrospinal fluid (CSF) were obtained. Both the CP and active metabolite of CP, nor-mustard (NM), concentrations were measured by the colorimetric assay method used 4-(p-Nitrobenzyl) pyridine (NBP) and the phamacokinetic parameters of CP and NM in plasma and CSF were estimated used a compartment model. The plasma concentration of CP peaked at the end of infusion, and there after decreased in a bi-exponential decay manner. The CSF concentration of CP peaked at the end of infusion, and then decreased in a mono-exponential decay manner. The plasma concentration of NM peaked 2 hours after drug administration and then gradually decreased. NM was not detectable in CSF. The area under the concentration-time curve (AUC) for the CSF of CP comprised only about 16.7% of that found in plasma. Those results suggested that the cytotoxicity of CP and NM in CSF was low because of the permeability of CP and NM into CSF was low.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"10 1","pages":"112-117"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80371966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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