Pub Date : 2000-01-01DOI: 10.5649/jjphcs1975.26.612
K. Hasegawa, F. Komada, Y. Saitoh
We prepared a database (689 KB) on 113 medicated syrups using Microsoft Access to quickly search information primarily concerning potential incompatibilities when dispensing medicated syrups. This database contains and allows access to data concerning 16 items such as trade names, compositions, additives, incompatibilities, and the recommended doses collected from interview forms, package inserts, in-housedocuments, and from the literature. It can also accurately calculate the pediatric dose based on the adult dose. The size of this database is 906 KB including the basic data of Microsoft Excel (226 KB) prepared for facilities that do not possess Microsoft Access so that the entire database can be used as a simple database that utilizes the filter function of Microsoft Excel and, with file conversion, can also be used on Windows CE and Macintosh systems. Moreover, these basic data are also available to a large number of people via the LAN and Internet when converted to FileMaker Pro 5. As a result of the use of this database, a mean of 0.9 cases of absolute incompatibilities and a mean of 1.8 cases of possible incompatibilities per item were revealed in the 113 items, and 64 items were found to contain phydroxybenzoic esters as additives, which have been suggested to have a possible side effect of inducing asthma attacks. The data on the dosage for children were missing in 26 items (about 23%). Furthermore, we investigated the rate of prescriptions including medicated syrups at two pharmacies. The rates at pharmacy A and B were about 11% and 2%, respectively. Thirty four % and 82% of the prescribed medicines included medicated syrups at pharmacy A and B. Sixty three % of the prescriptions for pediatrics patients included 3 or more medicated syrups. This database is thus considered to be useful for both preparing and evaluating prescriptions for medicated syrups, their dispensing, and also as a source for educating patients.
我们使用Microsoft Access编制了113种药物糖浆的数据库(689 KB)，以便在配药时快速搜索主要涉及潜在不兼容性的信息。该数据库包含并允许访问16个项目的数据，如商品名称、成分、添加剂、不兼容性和推荐剂量，这些数据收集自面谈表格、包装说明书、内部文件和文献。它还可以在成人剂量的基础上准确计算儿科剂量。该数据库的大小为906kb，其中包括为没有Microsoft Access的设备准备的Microsoft Excel的基本数据(226 KB)，因此整个数据库可以作为利用Microsoft Excel的过滤功能的简单数据库使用，并且可以进行文件转换，也可以在Windows CE和Macintosh系统上使用。而且，将这些基本数据转换为FileMaker Pro 5后，也可以通过局域网和互联网向很多人开放。使用该数据库，113个产品中平均每个产品存在0.9例绝对不相容，平均每个产品存在1.8例可能不相容，其中64个产品含有羟基苯甲酸酯作为添加剂，可能有诱发哮喘发作的副作用。26项(约23%)儿童用药剂量数据缺失。此外，我们还调查了两家药店的处方率，包括药用糖浆。A药房和B药房的比率分别约为11%和2%。分别有34%和82%的处方药物包括A药房和b药房的带药糖浆。儿科患者处方中有63%的处方药物包括3种或3种以上的带药糖浆。因此，该数据库被认为对制备和评估药用糖浆处方及其配药都很有用，也可作为教育患者的来源。
{"title":"Preparation and Trial Use of a Database of Medicated Syrups for Assistance in Drug Dispensing.","authors":"K. Hasegawa, F. Komada, Y. Saitoh","doi":"10.5649/jjphcs1975.26.612","DOIUrl":"https://doi.org/10.5649/jjphcs1975.26.612","url":null,"abstract":"We prepared a database (689 KB) on 113 medicated syrups using Microsoft Access to quickly search information primarily concerning potential incompatibilities when dispensing medicated syrups. This database contains and allows access to data concerning 16 items such as trade names, compositions, additives, incompatibilities, and the recommended doses collected from interview forms, package inserts, in-housedocuments, and from the literature. It can also accurately calculate the pediatric dose based on the adult dose. The size of this database is 906 KB including the basic data of Microsoft Excel (226 KB) prepared for facilities that do not possess Microsoft Access so that the entire database can be used as a simple database that utilizes the filter function of Microsoft Excel and, with file conversion, can also be used on Windows CE and Macintosh systems. Moreover, these basic data are also available to a large number of people via the LAN and Internet when converted to FileMaker Pro 5. As a result of the use of this database, a mean of 0.9 cases of absolute incompatibilities and a mean of 1.8 cases of possible incompatibilities per item were revealed in the 113 items, and 64 items were found to contain phydroxybenzoic esters as additives, which have been suggested to have a possible side effect of inducing asthma attacks. The data on the dosage for children were missing in 26 items (about 23%). Furthermore, we investigated the rate of prescriptions including medicated syrups at two pharmacies. The rates at pharmacy A and B were about 11% and 2%, respectively. Thirty four % and 82% of the prescribed medicines included medicated syrups at pharmacy A and B. Sixty three % of the prescriptions for pediatrics patients included 3 or more medicated syrups. This database is thus considered to be useful for both preparing and evaluating prescriptions for medicated syrups, their dispensing, and also as a source for educating patients.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"21 1","pages":"612-624"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90581396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.418
Mitsuru Kato, H. Okada, S. Takenaka, Y. Takakuwa, Noriko Mitsutake, T. Mitsui
A survey regarding understanding the images and demands of clinical trials was carried out on 177 ambulatory patients with rheumatoid arthritis at Aichi Medical University Hospital in April 1999. 72.3% of the study patients did not have a sufficient understanding of the clinical trials, while 27.7% of the patients did have a sufficient understanding. A total of 8.5%, of the patients had previous experience as trial subjects in clinical trials while 19.2% of the patients did not. In addition, 11.3% of the patients would take part of their own free will while 7.9% of the patients would refuse to take part in the trial. Many patients have an image that clinical trials are similar to experiments on humans. However, none of the patients with experience as subjects regretted their previous involvement in such trials. The reasons are clear why patients do not want to participate in clinical trials, since many people do not have a sufficient understanding of the effects of investigational drugs, are worried about the side effects of such drugs, and also have a general feeling of anxiety about such trials. These concerns have created a new role for hospital pharmacists as a CRC (Clinical Research Coordinator) to assist in the clinical trial process through medication counseling.
{"title":"Survey of Clinical Trials in Patients with Rheumatoid Arthritis.","authors":"Mitsuru Kato, H. Okada, S. Takenaka, Y. Takakuwa, Noriko Mitsutake, T. Mitsui","doi":"10.5649/JJPHCS1975.26.418","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.418","url":null,"abstract":"A survey regarding understanding the images and demands of clinical trials was carried out on 177 ambulatory patients with rheumatoid arthritis at Aichi Medical University Hospital in April 1999. 72.3% of the study patients did not have a sufficient understanding of the clinical trials, while 27.7% of the patients did have a sufficient understanding. A total of 8.5%, of the patients had previous experience as trial subjects in clinical trials while 19.2% of the patients did not. In addition, 11.3% of the patients would take part of their own free will while 7.9% of the patients would refuse to take part in the trial. Many patients have an image that clinical trials are similar to experiments on humans. However, none of the patients with experience as subjects regretted their previous involvement in such trials. The reasons are clear why patients do not want to participate in clinical trials, since many people do not have a sufficient understanding of the effects of investigational drugs, are worried about the side effects of such drugs, and also have a general feeling of anxiety about such trials. These concerns have created a new role for hospital pharmacists as a CRC (Clinical Research Coordinator) to assist in the clinical trial process through medication counseling.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"282 1","pages":"418-426"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76808281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.145
M. Myotoku, Kazunori Shimomura, Hisayuki Haji, T. Nishino
One of the side effects of cancer chemotherapy is the occurrence of stomatitis. Many studies have shown the effectiveness of a 0.1% allopurinol gargle for treating such stomatitis. Allopurinol gargle develops crystalline deposition a few days after preparation, and therefore it should befreshly prepared each time before use.We developed a prescription that delays crystalline deposition by adding glycerin to allopurinol gargle.Sterile allopurinol gargle (sterile ALT) was prepared by crushing allopurinol tablets, and then glycerin was added at various concentrations.The dissolved amount after 30 days was 0.65±0.05 mg/mL in sterile ALT without glycerin (sterile G0-ALT), 0.75±0.01 mg/mL in sterile ALT containing 1% glycerin (sterile G1-ALT), 0.79±0.03 mg/mL in sterile ALT containing 3% glycerin (sterile G 3-ALT), 0.89±0.06 mg/mL in sterile ALT containing 5% glycerin (sterile G 5-ALT), and 0.98±0.01 mg/mL in sterile ALT containing 10% glycerin (sterile G 10-ALT). The dissolved amount increased with the glycerin concentration.Allopurinol crystal deposition was observed after 2 days in sterile G 0-ALT, after 3 days in sterile G 1-ALT, after 6 days in sterile G 3-ALT, and after 10 days in sterile G 5-ALT, but could not be detected even after 30 days in sterile G 10-ALT.In tests of the sensation tastes during use in normal subjects, similar results were obtained between sterile G 10-ALT and sterile G 0-ALT. The xanthine oxidase (XOD) inhibitory activity was also similar between the two gargles.These results show that sterile G 10-ALT can be preserved for 30 days at 25°C, and its effects and sensation during use are similar to those of a prescription not containing glycerin.
{"title":"Pharmaceutical Study of Allopurinol Gargle Containing Glycerin.","authors":"M. Myotoku, Kazunori Shimomura, Hisayuki Haji, T. Nishino","doi":"10.5649/JJPHCS1975.26.145","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.145","url":null,"abstract":"One of the side effects of cancer chemotherapy is the occurrence of stomatitis. Many studies have shown the effectiveness of a 0.1% allopurinol gargle for treating such stomatitis. Allopurinol gargle develops crystalline deposition a few days after preparation, and therefore it should befreshly prepared each time before use.We developed a prescription that delays crystalline deposition by adding glycerin to allopurinol gargle.Sterile allopurinol gargle (sterile ALT) was prepared by crushing allopurinol tablets, and then glycerin was added at various concentrations.The dissolved amount after 30 days was 0.65±0.05 mg/mL in sterile ALT without glycerin (sterile G0-ALT), 0.75±0.01 mg/mL in sterile ALT containing 1% glycerin (sterile G1-ALT), 0.79±0.03 mg/mL in sterile ALT containing 3% glycerin (sterile G 3-ALT), 0.89±0.06 mg/mL in sterile ALT containing 5% glycerin (sterile G 5-ALT), and 0.98±0.01 mg/mL in sterile ALT containing 10% glycerin (sterile G 10-ALT). The dissolved amount increased with the glycerin concentration.Allopurinol crystal deposition was observed after 2 days in sterile G 0-ALT, after 3 days in sterile G 1-ALT, after 6 days in sterile G 3-ALT, and after 10 days in sterile G 5-ALT, but could not be detected even after 30 days in sterile G 10-ALT.In tests of the sensation tastes during use in normal subjects, similar results were obtained between sterile G 10-ALT and sterile G 0-ALT. The xanthine oxidase (XOD) inhibitory activity was also similar between the two gargles.These results show that sterile G 10-ALT can be preserved for 30 days at 25°C, and its effects and sensation during use are similar to those of a prescription not containing glycerin.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"8 1","pages":"145-156"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82865830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.304
K. Ueno, Megumi Morii, S. Ishida, A. Tamamura, Kana Matsumoto, Ayumi Oda, M. Takada, S. Kamakura, M. Shibakawa
The relationship between the serum trough concentrations of cibenzoline and the fasting blood glucose (FBG) levels were evaluated in 78 inpatients received cibenzoline therapy. As a result, as the serum trough concentrations of cibenzoline increased, the FBG levels decreased in inverse proportion. The FBG levels after the administration of cibenzoline decreased significantly (P<0.01) more than before administration. In addition, when the serum cibenzoline concentrations were higher the FBG levels also decreased significantly (P<0.01) more than when the serum concentrations were lower. The mean serum concentration when the FBG levels were less than 80mg/dL was higher than that when the FBG levels were lover 90mg/dL (383±273 vs 284±189ng/mL, P<0.071). These results suggest that more careful monitoring of the side effects of cibenzoline caused by a decrease in the FBG is thus needed in patients receiving cibenzoline therapy.
本文对78例接受齐苯唑啉治疗的住院患者血清谷浓度与空腹血糖(FBG)水平的关系进行了评价。结果表明，随着血药谷浓度的升高，空腹血糖水平呈反比下降。给药后FBG水平较给药前明显降低(P<0.01)。此外，当血清苯并啉浓度较高时，FBG水平也显著低于血清浓度较低时(P<0.01)。FBG < 80mg/dL时平均血药浓度高于FBG > 90mg/dL时(383±273 vs 284±189ng/mL, P<0.071)。这些结果表明，在接受苯并啉治疗的患者中，需要更仔细地监测由FBG下降引起的苯并啉副作用。
{"title":"Relationship between Serum Trough Concentrations of Cibenzoline and Fasting Blood Glucose Levels in Inpatiens Received Cibenzoline Therapy.","authors":"K. Ueno, Megumi Morii, S. Ishida, A. Tamamura, Kana Matsumoto, Ayumi Oda, M. Takada, S. Kamakura, M. Shibakawa","doi":"10.5649/JJPHCS1975.26.304","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.304","url":null,"abstract":"The relationship between the serum trough concentrations of cibenzoline and the fasting blood glucose (FBG) levels were evaluated in 78 inpatients received cibenzoline therapy. As a result, as the serum trough concentrations of cibenzoline increased, the FBG levels decreased in inverse proportion. The FBG levels after the administration of cibenzoline decreased significantly (P<0.01) more than before administration. In addition, when the serum cibenzoline concentrations were higher the FBG levels also decreased significantly (P<0.01) more than when the serum concentrations were lower. The mean serum concentration when the FBG levels were less than 80mg/dL was higher than that when the FBG levels were lover 90mg/dL (383±273 vs 284±189ng/mL, P<0.071). These results suggest that more careful monitoring of the side effects of cibenzoline caused by a decrease in the FBG is thus needed in patients receiving cibenzoline therapy.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"13 1","pages":"304-308"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87813032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.27
J. Hamada, T. Orii, E. Negishi, Yasuhiko Yamada, Hitoshi Sato, T. Iga
Database usage was evaluated regarding the retrieval of drug-induced adverse effect case reports. A search of case reports was performed using the on-line Medline (Ovid). Forty case reports were extracted from “Reactions” (adis INTERNATIONAL) used as secondary literature on adverse effects. From the original titles and abstracts, the name of the drugs and adverse effects were translated into Japanease and used to search data sets. After 6 pharmacists received a 30-minute explanation on how to use Medline since they had no previous experience in using Medline at the time of this study, the accessibility to the original case reports was examined and evaluated for their hitting rates. The hitting rates of the original data were 40-75%, and the data was divided into high-rate and low-rate groups. A major cause of a low hitting rate was that the “explode” function was not utilized to extend the terms of adverse effects. As a result, the “explode” function was found to be an important factor in effectively using Medline, especially when terms are not adequately chosen to retrieve case reports on adverse effects.
{"title":"Evaluation of Medline Utility for the Retrieval of Case Reports of Drug Adverse Effects.","authors":"J. Hamada, T. Orii, E. Negishi, Yasuhiko Yamada, Hitoshi Sato, T. Iga","doi":"10.5649/JJPHCS1975.26.27","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.27","url":null,"abstract":"Database usage was evaluated regarding the retrieval of drug-induced adverse effect case reports. A search of case reports was performed using the on-line Medline (Ovid). Forty case reports were extracted from “Reactions” (adis INTERNATIONAL) used as secondary literature on adverse effects. From the original titles and abstracts, the name of the drugs and adverse effects were translated into Japanease and used to search data sets. After 6 pharmacists received a 30-minute explanation on how to use Medline since they had no previous experience in using Medline at the time of this study, the accessibility to the original case reports was examined and evaluated for their hitting rates. The hitting rates of the original data were 40-75%, and the data was divided into high-rate and low-rate groups. A major cause of a low hitting rate was that the “explode” function was not utilized to extend the terms of adverse effects. As a result, the “explode” function was found to be an important factor in effectively using Medline, especially when terms are not adequately chosen to retrieve case reports on adverse effects.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"29 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74805956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.524
Mutsunobu Yoshioka, Kouichi Masaki, N. Kitada, Y. Ogawa, T. Tuji, M. Watari, K. Nagasawa, N. Ohnishi, T. Yokoyama, Kazuo Kuroda
{"title":"The Contribution of Hospital Pharmacists to Countermeasures for Intrahospital Infectionin of the Tuberculosis. Epidemic Research on Tuberculin Reaction in the General Hospital Staffs.","authors":"Mutsunobu Yoshioka, Kouichi Masaki, N. Kitada, Y. Ogawa, T. Tuji, M. Watari, K. Nagasawa, N. Ohnishi, T. Yokoyama, Kazuo Kuroda","doi":"10.5649/JJPHCS1975.26.524","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.524","url":null,"abstract":"","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"10 1","pages":"524-531"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75259283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.510
N. Hayase, M. Koeda, T. Awaya, C. Hara, Yasunori Yamashita, Kuniko Yamamoto, Y. Itagaki, K. Matubara
In recent years, transdermal tape preparations have been widely used for numerous patients. A major problem related to the use of such tape is skin irritation. This adverse event is considered to be due to the impermeability of water through the tape material during adhesion and the occurrence of skin, eruption after its removal. As a result, the water permeability of the tape materials and the amounts of stratum comeum stripped from the skin were studied on five transdermal nitrate tape preparations. The water permeability of the preparation, in which the polyester membrane was used for the backing body, depends on the membrane thickness: a thinner membrane has a higher water permeability. The highest permeability was detected in the Antup® preparation. On the other hand, the amount of stratum comeum stripped from the skin was significantly lower when the new Frandol tape S® preparation was applied. According to these results and other drug information such as the cost of the preparation, we evaluated the quality of these products based on decision analysis criteria. This evaluation thus accurately indicated the effectiveness, safety and cost of the product. As a result, the highest score was obtained by the new Frandol tape S® preparation among the five tested products. This product showed the lowest amount of stratum comeum and the low incidence of side effects. In other words, new Frandol tape S® appears to be the most cost-beneficial transdermal nitrate tape preparation. The method used in this study was thus shown to be useful for the selection of the safest and most effective transdermal tape preparation.
{"title":"The Evaluation of Transdermal Nitrate Tape Preparations on their Side Effects for Skin Irritation, Efficacies and Costs. The Determination of Water Permeability and Exfoliation of Stratum Corneum.","authors":"N. Hayase, M. Koeda, T. Awaya, C. Hara, Yasunori Yamashita, Kuniko Yamamoto, Y. Itagaki, K. Matubara","doi":"10.5649/JJPHCS1975.26.510","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.510","url":null,"abstract":"In recent years, transdermal tape preparations have been widely used for numerous patients. A major problem related to the use of such tape is skin irritation. This adverse event is considered to be due to the impermeability of water through the tape material during adhesion and the occurrence of skin, eruption after its removal. As a result, the water permeability of the tape materials and the amounts of stratum comeum stripped from the skin were studied on five transdermal nitrate tape preparations. The water permeability of the preparation, in which the polyester membrane was used for the backing body, depends on the membrane thickness: a thinner membrane has a higher water permeability. The highest permeability was detected in the Antup® preparation. On the other hand, the amount of stratum comeum stripped from the skin was significantly lower when the new Frandol tape S® preparation was applied. According to these results and other drug information such as the cost of the preparation, we evaluated the quality of these products based on decision analysis criteria. This evaluation thus accurately indicated the effectiveness, safety and cost of the product. As a result, the highest score was obtained by the new Frandol tape S® preparation among the five tested products. This product showed the lowest amount of stratum comeum and the low incidence of side effects. In other words, new Frandol tape S® appears to be the most cost-beneficial transdermal nitrate tape preparation. The method used in this study was thus shown to be useful for the selection of the safest and most effective transdermal tape preparation.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"41 1","pages":"510-517"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84856523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.505
H. Kokubun, Toshimi Kimura, S. Murase, S. Shimada, H. Kubo, M. Matsumoto, M. Nowatari, N. Matsuura
A simple and fast determination of plasma panipenem (PAPM) in extremely low birth weight infants was established using reversed phase high-performance liquid chromatography. Solutions of 35% methanol (pH 5.8), including 5 mM NaH2PO4 and 5 mM sodium dodecylsulfate, were used for the mobile phase. The flow rate was 0.8 mL/min. UV detection was carried out at 300 nm. The pretreatment method was as follows : 200 mM 3[morpholino] propansulfonic acid solution was added to the plasma as a stabilizer. It was then deproteinized with methanol. The calibration curve was linear in a range from 6.25 itƒÊg/mL to 100ƒÊg/mL. The recovery rate from known concentration samples of PAPM was 98.4%. The within-run and day-to-day variations were below 2.5% and 2.7%, respectively. The PAPM concentrations in the plasma were determined in five infants. In immature patients, an extension of the half-life was also observed.
建立了用反相高效液相色谱法快速测定极低出生体重儿血浆帕尼培南(PAPM)的方法。流动相为35%甲醇(pH为5.8)，溶液为5mm NaH2PO4和5mm十二烷基硫酸钠。流速0.8 mL/min。在300 nm处进行紫外检测。预处理方法为:在血浆中加入200 mM 3[morpholino]丙磺酸溶液作为稳定剂。然后用甲醇使其脱蛋白。校准曲线在6.25 itƒÊg/mL ~ 100ƒÊg/mL范围内呈线性关系。已知浓度样品的回收率为98.4%。运行内和日常变化分别低于2.5%和2.7%。测定了5例婴儿血浆中PAPM的浓度。在未成熟的患者中，还观察到半衰期延长。
{"title":"Determination of Plasma Panipenem Concentration in Neonates by High-Performance Liquid Chromatography.","authors":"H. Kokubun, Toshimi Kimura, S. Murase, S. Shimada, H. Kubo, M. Matsumoto, M. Nowatari, N. Matsuura","doi":"10.5649/JJPHCS1975.26.505","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.505","url":null,"abstract":"A simple and fast determination of plasma panipenem (PAPM) in extremely low birth weight infants was established using reversed phase high-performance liquid chromatography. Solutions of 35% methanol (pH 5.8), including 5 mM NaH2PO4 and 5 mM sodium dodecylsulfate, were used for the mobile phase. The flow rate was 0.8 mL/min. UV detection was carried out at 300 nm. The pretreatment method was as follows : 200 mM 3[morpholino] propansulfonic acid solution was added to the plasma as a stabilizer. It was then deproteinized with methanol. The calibration curve was linear in a range from 6.25 itƒÊg/mL to 100ƒÊg/mL. The recovery rate from known concentration samples of PAPM was 98.4%. The within-run and day-to-day variations were below 2.5% and 2.7%, respectively. The PAPM concentrations in the plasma were determined in five infants. In immature patients, an extension of the half-life was also observed.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"1 1","pages":"505-509"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90931947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.323
E. Usami, H. Shibata, M. Mizuno, Y. Seyama
{"title":"A Study for the Side Effect of Iron Products.","authors":"E. Usami, H. Shibata, M. Mizuno, Y. Seyama","doi":"10.5649/JJPHCS1975.26.323","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.323","url":null,"abstract":"","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"78 1","pages":"323-328"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90354456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.5649/JJPHCS1975.26.471
E. Muramatsu, T. Hanawa, Masahiko Suzuki, Mutsuko Tanaka, K. Kawano, S. Nakajima
The release behavior of diethylhexyl phthalate (DEHP, a plasticizer of polyvinyl chloride) from polyvinyl chloride (PVC) tubing caused by the coexistence of such surfactants as polysorbate 80 and polyoxyethylene castor oil (Tween 80 and HCO 60, a solubilizer for water insoluble drugs, respectively) in various solutions was investigated. The concentration of released DEHP increased as the concentration of Tween 80 increased. As the drip rate accelerated, the concentration of the released DEHP diminished. Based on a comparison of the release behaviors of DEHP observed in the solutions containing surfactant alone and a commercial injection, they were found to be compatible together. These results suggest that it is become feasible to predict the concentration of dissolved DEHP based on the concentration of the surfactant and the drip rate.
{"title":"Investigation of the Effect of the Coexistence of Surfactant on the Release Behavior of Diethylhexyl Phthalate from the Polyvinyl Chloride Tubing.","authors":"E. Muramatsu, T. Hanawa, Masahiko Suzuki, Mutsuko Tanaka, K. Kawano, S. Nakajima","doi":"10.5649/JJPHCS1975.26.471","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.471","url":null,"abstract":"The release behavior of diethylhexyl phthalate (DEHP, a plasticizer of polyvinyl chloride) from polyvinyl chloride (PVC) tubing caused by the coexistence of such surfactants as polysorbate 80 and polyoxyethylene castor oil (Tween 80 and HCO 60, a solubilizer for water insoluble drugs, respectively) in various solutions was investigated. The concentration of released DEHP increased as the concentration of Tween 80 increased. As the drip rate accelerated, the concentration of the released DEHP diminished. Based on a comparison of the release behaviors of DEHP observed in the solutions containing surfactant alone and a commercial injection, they were found to be compatible together. These results suggest that it is become feasible to predict the concentration of dissolved DEHP based on the concentration of the surfactant and the drip rate.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"17 1","pages":"471-477"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75673974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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