A one-pot synthetic protocol has been developed using aryl acetic acid as new and alternate surrogate for the synthesis of 4-aryl imidazoquinoxalines with molecular iodine-DMSO green catalytic system under classical heating at 100–110 °C. A variety of quinoxaline derivatives containing quinoline are prepared by using this methodology. This new protocol has a potential to tolerate broad substrates, that is, different amines and aryl acetic acids.
{"title":"Sequential Decarboxylation, Substitution, Cyclization and Oxidation with Iodine-DMSO Catalytic System: A New Methodology for the Construction of Imidazoquinoxaline Motifs","authors":"Yakkanti Chiranjeevi, Ganta Ravi Kumar, Lakinani Vaikunta Rao, Srinuvasarao Golagani, Gorle Simhachalam, Apuri Satyender","doi":"10.1002/slct.202404332","DOIUrl":"https://doi.org/10.1002/slct.202404332","url":null,"abstract":"<p>A one-pot synthetic protocol has been developed using aryl acetic acid as new and alternate surrogate for the synthesis of 4-aryl imidazoquinoxalines with molecular iodine-DMSO green catalytic system under classical heating at 100–110 °C. A variety of quinoxaline derivatives containing quinoline are prepared by using this methodology. This new protocol has a potential to tolerate broad substrates, that is, different amines and aryl acetic acids.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 44","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kriti Mehta, Aabid A. Wani, Subhash C. Sahoo, Prasad V. Bharatam
1,1-Diaminobenzalazine has been recently reported to catalyze different types of Michael addition reactions; this organic molecule has unique characteristic features for bifunctional organocatalysis. Organocatalysts were shown to be useful in different aldol/cyclization cascade reactions, it is important to establish whether 1,1-diaminobenzalazine can be employed in the aldol/cyclization cascade reactions. In this work, the synthesis of oxazolines with the help of organocatalyst, 1,1-diaminobenzalazine, has been reported. This method is relatively more efficient, cost-effective, and environmentally safe as it avoids the use of metal oxides as co-catalysts.
{"title":"Synthesis of Oxazolines using Aldol/Cyclization Cascade Reactions Employing 1,1-Diaminobenzalazine as Organocatalyst","authors":"Kriti Mehta, Aabid A. Wani, Subhash C. Sahoo, Prasad V. Bharatam","doi":"10.1002/slct.202405002","DOIUrl":"https://doi.org/10.1002/slct.202405002","url":null,"abstract":"<p>1,1-Diaminobenzalazine has been recently reported to catalyze different types of Michael addition reactions; this organic molecule has unique characteristic features for bifunctional organocatalysis. Organocatalysts were shown to be useful in different aldol/cyclization cascade reactions, it is important to establish whether 1,1-diaminobenzalazine can be employed in the aldol/cyclization cascade reactions. In this work, the synthesis of oxazolines with the help of organocatalyst, 1,1-diaminobenzalazine, has been reported. This method is relatively more efficient, cost-effective, and environmentally safe as it avoids the use of metal oxides as co-catalysts.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 44","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guanyu Liang, Prof. Ying Wang, Xinyu Dong, Prof. Fen Xu
The composite material of nano CuO loaded on ion exchange resin (CuO@CER) as the carrier was prepared successfully by constant temperature oscillation and hydrothermal synthesis methods. It was applied to the photoelectrocatalytic degradation of methylene blue (MB) as an organic pollutant, and further to explore the optimal conditions for CuO@CER photoelectrocatalytic degradation of MB. The results showed that the composite material had a typical core-shell structure, and the nano CuO loaded on the ion exchange resin had good crystallinity and high purity. CuO@CER exhibited excellent photocatalytic and photoelectrocatalytic performance towards MB, with degradation rates of 92.02% and 95.20% in 70 min under their respective optimal reaction conditions. Furthermore, the photoelectrocatalytic stability of CuO@CER was good relatively, and the degradation rates of MB exceeded 96% after 5 cycles of photoelectrocatalytic experiments. Free radical quenching experiments indicated that superoxide radicals were the main active groups during the photoelectrocatalysis. Additionally, the mechanism of photocatalytic degradation for MB under the electric field was briefly analyzed. This study will provide technical support for the photoelectrocatalytic degradation of organic dye wastewater.
{"title":"Core-shell Structured Nano CuO@CER Composites for the Photoelectrocatalytic Degradation of Methylene Blue","authors":"Guanyu Liang, Prof. Ying Wang, Xinyu Dong, Prof. Fen Xu","doi":"10.1002/slct.202403754","DOIUrl":"https://doi.org/10.1002/slct.202403754","url":null,"abstract":"<p>The composite material of nano CuO loaded on ion exchange resin (CuO@CER) as the carrier was prepared successfully by constant temperature oscillation and hydrothermal synthesis methods. It was applied to the photoelectrocatalytic degradation of methylene blue (MB) as an organic pollutant, and further to explore the optimal conditions for CuO@CER photoelectrocatalytic degradation of MB. The results showed that the composite material had a typical core-shell structure, and the nano CuO loaded on the ion exchange resin had good crystallinity and high purity. CuO@CER exhibited excellent photocatalytic and photoelectrocatalytic performance towards MB, with degradation rates of 92.02% and 95.20% in 70 min under their respective optimal reaction conditions. Furthermore, the photoelectrocatalytic stability of CuO@CER was good relatively, and the degradation rates of MB exceeded 96% after 5 cycles of photoelectrocatalytic experiments. Free radical quenching experiments indicated that superoxide radicals were the main active groups during the photoelectrocatalysis. Additionally, the mechanism of photocatalytic degradation for MB under the electric field was briefly analyzed. This study will provide technical support for the photoelectrocatalytic degradation of organic dye wastewater.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 44","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current work is focused on the designing of a green interpenetrating polymer network (IPN) PA@polyAAm:AN using polyvinyl alcohol-agar hybrid backbone and its subsequent conversion into an anion-exchanger PA@polyAAm:AN-AE through reduction of nitrile group in presence of LiAlH4. Further, the reduced form of IPN was quaternized using methyl iodide so that anion to anion exchange could take place between F− and I− anions. The primary objective of synthesizing an anion-exchanger was to eliminate F− ions from contaminated water through the utilization of a prepared device. During the optimization of different experimental parameters for getting the optimal anion-exchange capacity (AEC), the favorable conditions found were: pH, 9.0; contact period, 120 min; adsorbent dosage, 30 mg and initial F− ion concentration, 8.0 mg L−1. The pseudo-second order kinetic model best described the F− ions adsorption kinetics, with a 0.97 R2 value. The rate constant (KF) was found to be 2.3, which further supported the validity of the Freundlich isotherm. Thus, the current study has remarkable potential with a 79.99% adsorption capacity for eliminating F− ions. Moreover, the ecofriendly anion-exchanger prepared was found effective in the removal of F− ions from aqueous medium up to four cycles during reusability analysis.
{"title":"Fluoride Ions Sequestration From Contaminated Water Using PVA-Agar-Based Green Anion-Exchanger","authors":"Balram, Balbir Singh Kaith","doi":"10.1002/slct.202403080","DOIUrl":"https://doi.org/10.1002/slct.202403080","url":null,"abstract":"<p>The current work is focused on the designing of a green interpenetrating polymer network (IPN) PA@polyAAm:AN using polyvinyl alcohol-agar hybrid backbone and its subsequent conversion into an anion-exchanger PA@polyAAm:AN-AE through reduction of nitrile group in presence of LiAlH<sub>4</sub>. Further, the reduced form of IPN was quaternized using methyl iodide so that anion to anion exchange could take place between F<sup>−</sup> and I<sup>−</sup> anions. The primary objective of synthesizing an anion-exchanger was to eliminate F<sup>−</sup> ions from contaminated water through the utilization of a prepared device. During the optimization of different experimental parameters for getting the optimal anion-exchange capacity (AEC), the favorable conditions found were: pH, 9.0; contact period, 120 min; adsorbent dosage, 30 mg and initial F<sup>−</sup> ion concentration, 8.0 mg L<sup>−1</sup>. The pseudo-second order kinetic model best described the F<sup>−</sup> ions adsorption kinetics, with a 0.97 <i>R</i><sup>2</sup> value. The rate constant (<i>K</i><sub>F</sub>) was found to be 2.3, which further supported the validity of the Freundlich isotherm. Thus, the current study has remarkable potential with a 79.99% adsorption capacity for eliminating F<sup>−</sup> ions. Moreover, the ecofriendly anion-exchanger prepared was found effective in the removal of F<sup>−</sup> ions from aqueous medium up to four cycles during reusability analysis.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 44","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Priyesh H. Amin, Rajesh H. Vekariya, Sureshkumar K. Dhakhda
Fluorine, the most electronegative element, is currently used extensively in medicine, agrochemistry, and material science. Fluorinated compounds are expected to account for 30–50% of all active components now under development. It is difficult for medicinal chemists to discover new active compounds with higher efficacy, decreased mammalian toxicity, a better environmental profile, and a cheaper cost; yet, fluorinated pyrazole fits all of these criteria. The current review will provide an overview of the synthesis of pyrazoles with novel fluorinated substituents that have important uses in pharmaceutical and agricultural chemistry, with a focus on data published between 2011 and 2023. A concise table with the relevant literature references helped the reader to understand each derivative of fluorinated pyrazoles according to their biological activity.
{"title":"Recent Advances in Development of Bioactive Fluorinated Pyrazole Derivatives: A Review","authors":"Priyesh H. Amin, Rajesh H. Vekariya, Sureshkumar K. Dhakhda","doi":"10.1002/slct.202403478","DOIUrl":"https://doi.org/10.1002/slct.202403478","url":null,"abstract":"<p>Fluorine, the most electronegative element, is currently used extensively in medicine, agrochemistry, and material science. Fluorinated compounds are expected to account for 30–50% of all active components now under development. It is difficult for medicinal chemists to discover new active compounds with higher efficacy, decreased mammalian toxicity, a better environmental profile, and a cheaper cost; yet, fluorinated pyrazole fits all of these criteria. The current review will provide an overview of the synthesis of pyrazoles with novel fluorinated substituents that have important uses in pharmaceutical and agricultural chemistry, with a focus on data published between 2011 and 2023. A concise table with the relevant literature references helped the reader to understand each derivative of fluorinated pyrazoles according to their biological activity.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ekaterina N. Kudryavtseva, Boris V. Lichitsky, Evgeny V. Tretyakov
The reaction of different acyl hydrazines with hexafluoro-1,4-napthoquinone was studied for the first time. It was demonstrated that this interaction stops at the substitution of one fluorine atom in the quinone moiety. Based on the observed reaction, a general approach to the synthesis of different pentafluoro-1,4-dioxo-1,4-dihydronaphthalen-2-yl hydrazides was developed. It was revealed that optimal conditions for the condensation of hexafluoro-1,4-napthoquinone with hydrazides are reflux in MeOH for 0.25 h; note, the protocol does not require any chromatographic purification of the target products. The method is versatile and makes it possible to prepare products containing various substituents in the aryl part of the molecule. In addition, alkyl and heteroaryl hydrazides can be employed as starting compounds too, and the presence of hydroxy and cyano groups in the applied acyl hydrazines does not interfere with the condensation. The structure of one of the obtained products, namely 4-chloro-N□-(3,5,6,7,8-pentafluoro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzohydrazide, was confirmed by X-ray diffraction. In crystals of this hydrazide, both NH groups form intermolecular hydrogen bonds that give rise to layers lying in the [001] plane. Prepared N'-(3,5,6,7,8-pentafluoro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hydrazides are of interest as redox-active ligands and precursors for obtaining a wide range of functionalized 1,4-napthoquinones for medicine chemistry.
{"title":"Synthesis of Substituted N'-(3,5,6,7,8-Pentafluoro-1,4-Dioxo-1,4-Dihydronaphthalen-2-yl)Hydrazides by Condensation of Acyl Hydrazines and Perfluoro-1,4-Naphthoquinone","authors":"Ekaterina N. Kudryavtseva, Boris V. Lichitsky, Evgeny V. Tretyakov","doi":"10.1002/slct.202404996","DOIUrl":"https://doi.org/10.1002/slct.202404996","url":null,"abstract":"<p>The reaction of different acyl hydrazines with hexafluoro-1,4-napthoquinone was studied for the first time. It was demonstrated that this interaction stops at the substitution of one fluorine atom in the quinone moiety. Based on the observed reaction, a general approach to the synthesis of different pentafluoro-1,4-dioxo-1,4-dihydronaphthalen-2-yl hydrazides was developed. It was revealed that optimal conditions for the condensation of hexafluoro-1,4-napthoquinone with hydrazides are reflux in MeOH for 0.25 h; note, the protocol does not require any chromatographic purification of the target products. The method is versatile and makes it possible to prepare products containing various substituents in the aryl part of the molecule. In addition, alkyl and heteroaryl hydrazides can be employed as starting compounds too, and the presence of hydroxy and cyano groups in the applied acyl hydrazines does not interfere with the condensation. The structure of one of the obtained products, namely 4-chloro-N□-(3,5,6,7,8-pentafluoro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzohydrazide, was confirmed by X-ray diffraction. In crystals of this hydrazide, both NH groups form intermolecular hydrogen bonds that give rise to layers lying in the [001] plane. Prepared N'-(3,5,6,7,8-pentafluoro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hydrazides are of interest as redox-active ligands and precursors for obtaining a wide range of functionalized 1,4-napthoquinones for medicine chemistry.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Li, Zhongming Liu, Shoujuan Wang, Fangong Kong
Cellulose-based “biomass” adsorptive materials have gained significant attention because of their effectiveness in various applications. In this study, a cellulose composite aerogel with a rich three-dimensional network structure, low density, and high porosity was successfully obtained by the in situ self-polymerization of dopamine (DA) and acrylamide (AM) in an alkaline urine system. Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, elemental analysis, and other analytical techniques were used to analyze the physical and chemical structures of the cellulose composite aerogels. The results revealed that the introduction of DA and AM into the aerogel enhanced the adsorption and mechanical properties of the active sites, thereby boosting adsorption capacity and recyclability. By optimizing the adsorption of methylene blue (MB) dye using a cellulose composite aerogel, a maximum adsorption capacity of 406.89 mg g was obtained. The MB dye adsorption curve of the cellulose composite aerogel conformed to the Langmuir model, which indicates high adsorption capacity and recyclability. This confirms the high application potential of the cellulose composite aerogel in wastewater treatments.
纤维素基 "生物质 "吸附材料因其在各种应用中的有效性而备受关注。本研究通过多巴胺(DA)和丙烯酰胺(AM)在碱性尿液体系中的原位自聚合反应,成功获得了一种具有丰富三维网络结构、低密度和高孔隙率的纤维素复合气凝胶。傅立叶变换红外光谱、扫描电子显微镜、X射线光电子能谱、元素分析等分析技术用于分析纤维素复合气凝胶的物理和化学结构。结果表明,在气凝胶中引入 DA 和 AM 可增强活性位点的吸附性和机械性能,从而提高吸附能力和可回收性。通过优化纤维素复合气凝胶对亚甲基蓝(MB)染料的吸附,获得了 406.89 mg g 的最大吸附容量。纤维素复合气凝胶对亚甲蓝染料的吸附曲线符合 Langmuir 模型,这表明它具有很高的吸附能力和可回收性。这证实了纤维素复合气凝胶在废水处理中的巨大应用潜力。
{"title":"Cellulose Composite Aerogels with High Adsorption Capacity and Recyclability for Dye Removal","authors":"Yang Li, Zhongming Liu, Shoujuan Wang, Fangong Kong","doi":"10.1002/slct.202402801","DOIUrl":"https://doi.org/10.1002/slct.202402801","url":null,"abstract":"<p>Cellulose-based “biomass” adsorptive materials have gained significant attention because of their effectiveness in various applications. In this study, a cellulose composite aerogel with a rich three-dimensional network structure, low density, and high porosity was successfully obtained by the in situ self-polymerization of dopamine (DA) and acrylamide (AM) in an alkaline urine system. Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, elemental analysis, and other analytical techniques were used to analyze the physical and chemical structures of the cellulose composite aerogels. The results revealed that the introduction of DA and AM into the aerogel enhanced the adsorption and mechanical properties of the active sites, thereby boosting adsorption capacity and recyclability. By optimizing the adsorption of methylene blue (MB) dye using a cellulose composite aerogel, a maximum adsorption capacity of 406.89 mg g was obtained. The MB dye adsorption curve of the cellulose composite aerogel conformed to the Langmuir model, which indicates high adsorption capacity and recyclability. This confirms the high application potential of the cellulose composite aerogel in wastewater treatments.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cansu İlke Kuru-Sumer, Fulden Ulucan-Karnak, Sinan Akgöl
Affınity based hybrid nanopolymeric membranes were developed in this work as a support material to immobilize urease. The hybrid membrane exhibits the desired characteristics and has potential applications in biotechnological and biomedical processes, particularly in artificial kidney devices that remove urea from blood. In this study, it was aimed to embed p(GMA) (glycidylmethacrylate) nanoparticles into HEMA(2-hydroxyethylmethacrylate) membranes and use them in urease enzyme immobilization. First, p(GMA) nanoparticles were synthesized with surfactant-free emulsion polymerization method. Then, a hybrid affinity system was developed by embedding p(GMA) nanoparticles in the p(HEMA) polymeric membranes synthesized by the free radical photopolymerization method. Following the characterization studies with dry mass analysis, scanning electron microscopy (SEM) analysis, Fourier-transform infrared spectroscopy (FTIR) analysis, Brunauer–Emmett–Teller (BET) analysis, surface area calculations, and swelling tests of the hybrid membranes, and conditions (pH, temperature, and concentration) were optimized for urease immobilization. Urease was immobilized onto p(GMA) nanoparticles embedded in p(HEMA) hybrid membranes via adsorption. The maximum urease immobilization capacity of the p(GMA) nanoparticles embedded in p(HEMA) hybrid membranes was 31.85 µg/g. The hybrid membrane exhibits the desired characteristics and has potential applications in biotechnological and biomedical processes, particularly in artificial kidney devices that remove urea from blood.
{"title":"Urease Immobilization with Affinity Based Hybrid Nanopolymeric Membranes","authors":"Cansu İlke Kuru-Sumer, Fulden Ulucan-Karnak, Sinan Akgöl","doi":"10.1002/slct.202403297","DOIUrl":"https://doi.org/10.1002/slct.202403297","url":null,"abstract":"<p>Affınity based hybrid nanopolymeric membranes were developed in this work as a support material to immobilize urease. The hybrid membrane exhibits the desired characteristics and has potential applications in biotechnological and biomedical processes, particularly in artificial kidney devices that remove urea from blood. In this study, it was aimed to embed p(GMA) (glycidylmethacrylate) nanoparticles into HEMA(2-hydroxyethylmethacrylate) membranes and use them in urease enzyme immobilization. First, p(GMA) nanoparticles were synthesized with surfactant-free emulsion polymerization method. Then, a hybrid affinity system was developed by embedding p(GMA) nanoparticles in the p(HEMA) polymeric membranes synthesized by the free radical photopolymerization method. Following the characterization studies with dry mass analysis, scanning electron microscopy (SEM) analysis, Fourier-transform infrared spectroscopy (FTIR) analysis, Brunauer–Emmett–Teller (BET) analysis, surface area calculations, and swelling tests of the hybrid membranes, and conditions (pH, temperature, and concentration) were optimized for urease immobilization. Urease was immobilized onto p(GMA) nanoparticles embedded in p(HEMA) hybrid membranes via adsorption. The maximum urease immobilization capacity of the p(GMA) nanoparticles embedded in p(HEMA) hybrid membranes was 31.85 µg/g. The hybrid membrane exhibits the desired characteristics and has potential applications in biotechnological and biomedical processes, particularly in artificial kidney devices that remove urea from blood.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zia ur Rehman, Muhammad Aslam Khan, Nouman Rasheed Jathoi, Usama Rasool, Khalid S Almaary, Needa A. Bahkali, Junaid Ihsan, Syed Ali Imran Bokhari
This study compares chemical and green synthesized zinc sulfide nanoparticles for multiple biological properties. A chemical synthesis approach is utilized to synthesize PEGylated ZnS-NPs while the bulbs of Fritillariae cirrhosae bulbus are utilized for green synthesis. After extensive characterization, the NPs are examined for multifunctional biological properties such as antimicrobial, antioxidant, in vitro anticancer, and blood compatibility. Our study found that chemical synthesis results in higher yield and better dispersion behavior. However, the green ZnS-NPs possessed increased antibacterial and antiparasitic potential against Leishmania tropica as the NPs resulted in significant inhibition against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) with minimum inhibitory concentration (MIC) of 0.156 and 0.312 mg/mL, respectively while IC50 of 115.21 and 128.5 µg/mL were observed for the promastigote and amastigote forms of parasite. Furthermore, Fritillaria cirrhosa (F. cirrhosa) synthesized NPs possessed slightly improved antioxidant properties and in vitro anticancer potential against MCF-7 breast cancer cells. Despite differences in the biological properties, the NPs did not result in hemolytic behavior thus demonstrating the compatible nature against blood cells. It was thus evident from the present study that the chemical and green synthesis techniques not only result in NPs with different physicochemical characteristics but also significantly influence the bio-interaction of the obtained ZnS-NPs.
{"title":"A Comparative Study of Green and Chemically Prepared PEGylated Zinc Sulfide Nanoparticles (ZnS-NPs) for Biological Applications","authors":"Zia ur Rehman, Muhammad Aslam Khan, Nouman Rasheed Jathoi, Usama Rasool, Khalid S Almaary, Needa A. Bahkali, Junaid Ihsan, Syed Ali Imran Bokhari","doi":"10.1002/slct.202403736","DOIUrl":"https://doi.org/10.1002/slct.202403736","url":null,"abstract":"<p>This study compares chemical and green synthesized zinc sulfide nanoparticles for multiple biological properties. A chemical synthesis approach is utilized to synthesize PEGylated ZnS-NPs while the bulbs of <i>Fritillariae cirrhosae bulbus</i> are utilized for green synthesis. After extensive characterization, the NPs are examined for multifunctional biological properties such as antimicrobial, antioxidant, in vitro anticancer, and blood compatibility. Our study found that chemical synthesis results in higher yield and better dispersion behavior. However, the green ZnS-NPs possessed increased antibacterial and antiparasitic potential against <i>Leishmania tropica</i> as the NPs resulted in significant inhibition against <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and <i>Bacillus subtilis</i> (<i>B. subtilis</i>) with minimum inhibitory concentration (MIC) of 0.156 and 0.312 mg/mL, respectively while IC50 of 115.21 and 128.5 µg/mL were observed for the promastigote and amastigote forms of parasite. Furthermore, <i>Fritillaria cirrhosa</i> (<i>F. cirrhosa)</i> synthesized NPs possessed slightly improved antioxidant properties and in vitro anticancer potential against MCF-7 breast cancer cells. Despite differences in the biological properties, the NPs did not result in hemolytic behavior thus demonstrating the compatible nature against blood cells. It was thus evident from the present study that the chemical and green synthesis techniques not only result in NPs with different physicochemical characteristics but also significantly influence the bio-interaction of the obtained ZnS-NPs.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhi-Jun Chen, Cong Huang, Zhen-Zhen Xie, Zhu-Jun Wang, Yu Zheng, Hao-Yue Xiang, Kai Chen, Hua Yang
Herein, we developed a metal-free, photosensitized strategy for difunctionalization of olefin feedstocks to access β-amino sulphone architectures, enabled by a tailor-made, readily accessible sulfonylamide bifunctional reagent. This protocol could accommodate a wide range of alkenes and a variety of sulfonylamides, with high yields and excellent regioselectivity. Given remarkably mild reaction conditions, readily accessible starting materials, excellent functional group tolerance, and well-defined regioselectivity, this approach would enable an efficient platform for the assembly of densely functionalized molecular scaffolds.
{"title":"Photosensitized 1,2-Sulfonylamination of Alkenes With Sulfonylamide","authors":"Zhi-Jun Chen, Cong Huang, Zhen-Zhen Xie, Zhu-Jun Wang, Yu Zheng, Hao-Yue Xiang, Kai Chen, Hua Yang","doi":"10.1002/slct.202404815","DOIUrl":"https://doi.org/10.1002/slct.202404815","url":null,"abstract":"<p>Herein, we developed a metal-free, photosensitized strategy for difunctionalization of olefin feedstocks to access β-amino sulphone architectures, enabled by a tailor-made, readily accessible sulfonylamide bifunctional reagent. This protocol could accommodate a wide range of alkenes and a variety of sulfonylamides, with high yields and excellent regioselectivity. Given remarkably mild reaction conditions, readily accessible starting materials, excellent functional group tolerance, and well-defined regioselectivity, this approach would enable an efficient platform for the assembly of densely functionalized molecular scaffolds.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}