Pub Date : 2023-12-25DOI: 10.35516/jjps.v16i4.2086
Ghada Abdulmunim Mohammed
This in vitro study was undertaken with the aim of testing the efficacy of the tissue conditioner mixed with four different commercially available herbal oils (Origanum oil, (Nigella sativa) Black seeds oil, Garlic oil, and Ginger oil) against Candida albicans. Control groups tested with antifungal test discs included fluconazole, flucytosine, and tissue conditioner discs (Acrosoft). The susceptibility test of plant extracts alone was also conducted. The combination groups tested were Acrosoft mixed with ginger oil, Acrosoft mixed with origanum oil, Acrosoft mixed with black seed oil, and Acrosoft with garlic oil. Test discs were completely embedded in the tissue conditioner mixed with plant extracts and gently placed on the agar plates. The plates were incubated at 35 °C for 72 hours. After incubation, inhibiting diameters of various groups were noted. There was complete resistance of Candida albicans to both fluconazole and flucytosine, and there was no inhibition zone observed regarding the susceptibility of ginger oil, origanum oil, black seed oil, and garlic oils. Similarly, there was no inhibition of Candida albicans observed in Acrosoft material. For the combination of tissue conditioner with plant extracts, results showed no inhibition in black seed oil and ginger oil combined with tissue conditioner. In contrast, the combination of garlic oil and origanum oil with tissue conditioner showed a zone of inhibition, and the inhibition diameters ranged from 5-9 mm.
{"title":"Studying The Anti Candidal-Activity of Different Herbal Oils Incorporated into Tissue Conditioner: (A Comparative study)","authors":"Ghada Abdulmunim Mohammed","doi":"10.35516/jjps.v16i4.2086","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.2086","url":null,"abstract":"This in vitro study was undertaken with the aim of testing the efficacy of the tissue conditioner mixed with four different commercially available herbal oils (Origanum oil, (Nigella sativa) Black seeds oil, Garlic oil, and Ginger oil) against Candida albicans. Control groups tested with antifungal test discs included fluconazole, flucytosine, and tissue conditioner discs (Acrosoft). The susceptibility test of plant extracts alone was also conducted. The combination groups tested were Acrosoft mixed with ginger oil, Acrosoft mixed with origanum oil, Acrosoft mixed with black seed oil, and Acrosoft with garlic oil. Test discs were completely embedded in the tissue conditioner mixed with plant extracts and gently placed on the agar plates. The plates were incubated at 35 °C for 72 hours. After incubation, inhibiting diameters of various groups were noted. There was complete resistance of Candida albicans to both fluconazole and flucytosine, and there was no inhibition zone observed regarding the susceptibility of ginger oil, origanum oil, black seed oil, and garlic oils. Similarly, there was no inhibition of Candida albicans observed in Acrosoft material. For the combination of tissue conditioner with plant extracts, results showed no inhibition in black seed oil and ginger oil combined with tissue conditioner. In contrast, the combination of garlic oil and origanum oil with tissue conditioner showed a zone of inhibition, and the inhibition diameters ranged from 5-9 mm.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed I.M. Aladul, Ibraheem A. Jamel, Thanoon A. Thanoon, Fatima F. Abd-Alrazzaq, Zainab S. Shaker, Tabarak M. Jassim
Background: Job satisfaction is a multifaceted construct that involves the intricate interplay of an employee's emotional, cognitive, and behavioral characteristics with their job. Objectives: To explore the difference in job satisfaction among alumni and student medical representatives (MRs), as well as to identify the factors that influence the job satisfaction of MRs. Methods: A cross-sectional face-to-face survey was conducted with medical school students and alumni working as MRs in various Iraqi universities. Results: A total of 449 MRs participated in this study. A statistically significant difference was found in job satisfaction items, namely recognition, responsibility, salary, and working conditions between alumni and student MRs, with higher values observed in the alumni MRs group (p-values of 0.008, 0.003, 0.029, and 0.025, respectively). More than half of the participants had low levels of job satisfaction. Conclusions: Alumni and student MRs have similar levels of job satisfaction. The factors that significantly contribute to job satisfaction among alumni MRs include recognition of good performance, increased autonomy and responsibilities, competitive salaries, and improved working conditions within the company. The satisfaction of MRs is significantly influenced by the quality of products and the reputation of the company.
{"title":"Comparison of Job Satisfaction by Alumni and Student Medical Representatives and The Associated Factors in Iraq","authors":"Mohammed I.M. Aladul, Ibraheem A. Jamel, Thanoon A. Thanoon, Fatima F. Abd-Alrazzaq, Zainab S. Shaker, Tabarak M. Jassim","doi":"10.35516/jjps.v16i4.927","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.927","url":null,"abstract":"Background: Job satisfaction is a multifaceted construct that involves the intricate interplay of an employee's emotional, cognitive, and behavioral characteristics with their job. Objectives: To explore the difference in job satisfaction among alumni and student medical representatives (MRs), as well as to identify the factors that influence the job satisfaction of MRs. Methods: A cross-sectional face-to-face survey was conducted with medical school students and alumni working as MRs in various Iraqi universities. Results: A total of 449 MRs participated in this study. A statistically significant difference was found in job satisfaction items, namely recognition, responsibility, salary, and working conditions between alumni and student MRs, with higher values observed in the alumni MRs group (p-values of 0.008, 0.003, 0.029, and 0.025, respectively). More than half of the participants had low levels of job satisfaction. Conclusions: Alumni and student MRs have similar levels of job satisfaction. The factors that significantly contribute to job satisfaction among alumni MRs include recognition of good performance, increased autonomy and responsibilities, competitive salaries, and improved working conditions within the company. The satisfaction of MRs is significantly influenced by the quality of products and the reputation of the company.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139158763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-25DOI: 10.35516/jjps.v16i4.1327
Md. Kamrul Hasan Arnab, Moynul Hasan, Md. Monirul Islam
Numerous amphibian species, particularly those of the genus Rana, have been found to produce linear, amphiphilic, and cationic antimicrobial peptides (AMPs). Such AMPs are gaining more attention in pharmaceutical applications due to their principal method of action, which involves penetrating and rupturing the intended cell membranes with relatively low resistance. Brevinin is a large family of AMPs extensively studied during the last few decades, primarily consisting of two groups of peptides: Brevinin-1 and Brevinin-2. These peptides are cationic and establish secondary structures in the biological membrane environment. In this discussion, we explore the effects of structural parameters (net charge, hydrophobicity, amphiphilicity, helicity, peptide length, etc.) of Brevinin on their antimicrobial activity. As a general rule, an increased net charge tends to enhance antimicrobial activity. However, it is important to note that excessive net charges can also elevate hemolytic activity. The amino acid composition significantly influences hydrophobicity and helicity, which, in turn, impact the activity of the peptides. Moreover, these structural parameters are interconnected; modifying one parameter will affect others. Striking an optimal balance in these factors will provide a Brevinin analog with the highest antimicrobial activity and the lowest hemolytic activity.
{"title":"Insight into the Structure-Activity Relationship of Antimicrobial Peptide Brevinin","authors":"Md. Kamrul Hasan Arnab, Moynul Hasan, Md. Monirul Islam","doi":"10.35516/jjps.v16i4.1327","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.1327","url":null,"abstract":"Numerous amphibian species, particularly those of the genus Rana, have been found to produce linear, amphiphilic, and cationic antimicrobial peptides (AMPs). Such AMPs are gaining more attention in pharmaceutical applications due to their principal method of action, which involves penetrating and rupturing the intended cell membranes with relatively low resistance. Brevinin is a large family of AMPs extensively studied during the last few decades, primarily consisting of two groups of peptides: Brevinin-1 and Brevinin-2. These peptides are cationic and establish secondary structures in the biological membrane environment. In this discussion, we explore the effects of structural parameters (net charge, hydrophobicity, amphiphilicity, helicity, peptide length, etc.) of Brevinin on their antimicrobial activity. As a general rule, an increased net charge tends to enhance antimicrobial activity. However, it is important to note that excessive net charges can also elevate hemolytic activity. The amino acid composition significantly influences hydrophobicity and helicity, which, in turn, impact the activity of the peptides. Moreover, these structural parameters are interconnected; modifying one parameter will affect others. Striking an optimal balance in these factors will provide a Brevinin analog with the highest antimicrobial activity and the lowest hemolytic activity.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139158951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-25DOI: 10.35516/jjps.v16i4.1365
D. T. Huynh, Minh-Ngoc T. Le, V. D. Tran, Viet-Hung Tran, D. T. Pham
Cancer, one of the deadliest diseases worldwide, is projected to affect 30.2 million people by 2040. Among the various cancer types, rhabdomyosarcoma (RMS) is a unique tumor primarily impacting the muscular system of children. The current treatment for RMS has limited efficacy and numerous side effects, emphasizing the need for novel therapeutic approaches. This study investigates the potential treatment of the RMS cell line RD using extracts from five folklore-based medicinal plants in An Giang, Vietnam. The plants—Moringa oleifera Lam, Brucea javanica (L.) Merr., Eclipta prostrata (L.), Callisia fragrans (Lindl.) Woodson, and Zingiber zerumbet (L.) Smith—were extracted and fractionated using three solvents: ether, ethanol, and water. These fractions underwent phytochemical screening and cytotoxicity testing on the in-vitro RMS cell line RD. The results indicate that the ether fraction of Eclipta prostrata (L.) and the ether and ethanol fractions of Zingiber zerumbet (L.) Smith exhibit moderate cytotoxic effects on RD cell lines, with IC50 values of 37.08 ± 1.23 µg/mL, 23.15 ± 1.17 µg/mL, and 45.63 ± 2.39 µg/mL, respectively. These findings provide preliminary data for further in-depth research into the anticancer properties of these plants, which are widely grown in the South of Vietnam.
{"title":"Native Medicinal Plants (Moringa oleifera Lam, Brucea javanica (L.) Merr., Eclipta prostrata (L.), Callisia fragrans (Lindl.) Woodson, and Zingiber zerumbet (L.) Smith) in An Giang, Vietnam: A Preliminary Investigation for Rhabdomyosarcoma Treatments using in-vitro RD cell cytotoxicity test","authors":"D. T. Huynh, Minh-Ngoc T. Le, V. D. Tran, Viet-Hung Tran, D. T. Pham","doi":"10.35516/jjps.v16i4.1365","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.1365","url":null,"abstract":"Cancer, one of the deadliest diseases worldwide, is projected to affect 30.2 million people by 2040. Among the various cancer types, rhabdomyosarcoma (RMS) is a unique tumor primarily impacting the muscular system of children. The current treatment for RMS has limited efficacy and numerous side effects, emphasizing the need for novel therapeutic approaches. This study investigates the potential treatment of the RMS cell line RD using extracts from five folklore-based medicinal plants in An Giang, Vietnam. The plants—Moringa oleifera Lam, Brucea javanica (L.) Merr., Eclipta prostrata (L.), Callisia fragrans (Lindl.) Woodson, and Zingiber zerumbet (L.) Smith—were extracted and fractionated using three solvents: ether, ethanol, and water. These fractions underwent phytochemical screening and cytotoxicity testing on the in-vitro RMS cell line RD. The results indicate that the ether fraction of Eclipta prostrata (L.) and the ether and ethanol fractions of Zingiber zerumbet (L.) Smith exhibit moderate cytotoxic effects on RD cell lines, with IC50 values of 37.08 ± 1.23 µg/mL, 23.15 ± 1.17 µg/mL, and 45.63 ± 2.39 µg/mL, respectively. These findings provide preliminary data for further in-depth research into the anticancer properties of these plants, which are widely grown in the South of Vietnam.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139158386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nateglinide is an anti-diabetic agent that experiences modest first-pass metabolism and poor aqueous solubility. This paper explores the preparation, characterization, and evaluation of interpenetrating polymer network composite hydrogels of chitosan and poly(meth(methacrylic)) acid as a potential carrier for the drug. Interpenetrating polymer network composite hydrogels of chitosan and poly(meth(methacrylic) acid incorporating nateglinide were prepared using N,Nꞌ-methylene bisacrylamide and glutaraldehyde as cross-linkers. The polymerization of chitosan, entrapment of the drug, and its interaction in prepared hydrogels were checked by FTIR spectroscopy, DSC, and powder XRD studies. The hydrogels were evaluated for their swelling behavior and in vitro drug release. The morphology of the hydrogels before and after dissolution was studied using SEM. The hydrogels showed a 93.29 ± 4.65% yield and 91.28 ± 2.22% drug loading. The hydrogels exhibited pH-sensitive swelling behavior. The in vitro release profile confirmed that the drug release depended on the swelling of hydrogels and showed a biphasic release pattern. Chitosan-poly(meth(methacrylic)) acid interpenetrating polymer network hydrogel, with its biodegradable nature and pH-sensitive release of nateglinide, is an attractive option to be further explored for targeted controlled drug delivery formulations for the drug.
{"title":"Fabrication of Interpenetrating Polymer Network-Based Hydrogel for Colon-Targeted Release of Nateglinide","authors":"Daxaben Kothiya, Subhash S. Vaghani","doi":"10.35516/jjps.v16i4.775","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.775","url":null,"abstract":"Nateglinide is an anti-diabetic agent that experiences modest first-pass metabolism and poor aqueous solubility. This paper explores the preparation, characterization, and evaluation of interpenetrating polymer network composite hydrogels of chitosan and poly(meth(methacrylic)) acid as a potential carrier for the drug. Interpenetrating polymer network composite hydrogels of chitosan and poly(meth(methacrylic) acid incorporating nateglinide were prepared using N,Nꞌ-methylene bisacrylamide and glutaraldehyde as cross-linkers. The polymerization of chitosan, entrapment of the drug, and its interaction in prepared hydrogels were checked by FTIR spectroscopy, DSC, and powder XRD studies. The hydrogels were evaluated for their swelling behavior and in vitro drug release. The morphology of the hydrogels before and after dissolution was studied using SEM. The hydrogels showed a 93.29 ± 4.65% yield and 91.28 ± 2.22% drug loading. The hydrogels exhibited pH-sensitive swelling behavior. The in vitro release profile confirmed that the drug release depended on the swelling of hydrogels and showed a biphasic release pattern. Chitosan-poly(meth(methacrylic)) acid interpenetrating polymer network hydrogel, with its biodegradable nature and pH-sensitive release of nateglinide, is an attractive option to be further explored for targeted controlled drug delivery formulations for the drug.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139158481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salevendula Sreelekha, Vinod Kumar, N. Mahammed, T. Reshma, U. Sree, Shakir Basha, M. Bhuvaneswari
Quality by Design (QbD) is an essential approach to pharmaceutical development and manufacturing that has garnered significant attention in recent years. Quality in services, products, and procedures equates to customer satisfaction. Consequently, it facilitates a transition in the pharmaceutical sector and the Food and Drug Administration (FDA) toward a more scientific, risk-based, comprehensive, and proactive drug development strategy. The pharmaceutical industry is actively seeking new solutions to ensure product quality and efficiency. This paper provides a comprehensive overview of QbD principles and their application in the pharmaceutical industry. The benefits of implementing QbD principles are discussed, encompassing increased efficiency, reduced costs, and improved product quality, safety, and efficacy. As the pharmaceutical industry continues to evolve, QbD will remain a crucial aspect of drug development and manufacturing. This article aims to provide pharmaceutical professionals with a comprehensive understanding of the QbD approach.
{"title":"Quality by Design Approaches in Pharmaceutical Development and Solid Dosage Forms Production: A Narrative Overview","authors":"Salevendula Sreelekha, Vinod Kumar, N. Mahammed, T. Reshma, U. Sree, Shakir Basha, M. Bhuvaneswari","doi":"10.35516/jjps.v16i4.908","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.908","url":null,"abstract":"Quality by Design (QbD) is an essential approach to pharmaceutical development and manufacturing that has garnered significant attention in recent years. Quality in services, products, and procedures equates to customer satisfaction. Consequently, it facilitates a transition in the pharmaceutical sector and the Food and Drug Administration (FDA) toward a more scientific, risk-based, comprehensive, and proactive drug development strategy. The pharmaceutical industry is actively seeking new solutions to ensure product quality and efficiency. This paper provides a comprehensive overview of QbD principles and their application in the pharmaceutical industry. The benefits of implementing QbD principles are discussed, encompassing increased efficiency, reduced costs, and improved product quality, safety, and efficacy. As the pharmaceutical industry continues to evolve, QbD will remain a crucial aspect of drug development and manufacturing. This article aims to provide pharmaceutical professionals with a comprehensive understanding of the QbD approach.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139158398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this work is to study the serum levels of 25-hydroxyvitamin D3 in a sample of healthy Syrians in the city of Homs. Method: A cross-sectional study, including 690 ostensibly healthy participants, was conducted at the National Hospital of Homs. Serum levels of 25-hydroxyvitamin D3 were measured using chemiluminescent immunoassay. Results: The overall prevalence of vitamin D inadequacy (insufficiency, deficiency, and severe deficiency) in the study samples was 76.5%. Additionally, 49% of the samples had vitamin D deficiency, with 18.5% suffering from severe deficiency. Furthermore, levels of 25-hydroxyvitamin D3 in females were lower than in males (11.3±2.3 ng/ml versus 39.6±11.28 ng/ml, respectively, p < 0.0001). Veiled women had serum levels of vitamin D lower than non-veiled women, 11.3±2.5 ng/ml versus 25.5±3.2 ng/ml, respectively, p < 0.0001. Female gender and clothing style were identified as independent risk factors for vitamin D deficiency. Conclusion: The prevalence of vitamin D deficiency was very common in the study population, despite the sunny weather in Homs city most of the year. Further studies with larger groups, including other Syrian governorates, are needed to elucidate lifestyle and sociocultural behavior risk factors for vitamin D deficiency.
研究目的这项工作旨在研究霍姆斯市健康叙利亚人血清中 25- 羟维生素 D3 的水平。方法：横断面研究：霍姆斯国立医院开展了一项横断面研究，其中包括 690 名表面上健康的参与者。采用化学发光免疫测定法测定了血清中 25- 羟维生素 D3 的水平。结果显示研究样本中维生素 D 不足（不足、缺乏和严重缺乏）的总体患病率为 76.5%。此外，49%的样本存在维生素 D 缺乏症，其中 18.5%为严重缺乏症。此外，女性的 25- 羟维生素 D3 水平低于男性（分别为 11.3±2.3 纳克/毫升和 39.6±11.28 纳克/毫升，P < 0.0001）。蒙面女性的血清维生素 D 水平低于未蒙面女性，分别为 11.3±2.5 ng/ml 对 25.5±3.2 ng/ml，p < 0.0001。女性性别和服装款式被确定为维生素 D 缺乏的独立风险因素。结论尽管霍姆斯市全年大部分时间阳光明媚，但研究人群中维生素 D 缺乏症的发病率非常普遍。需要对包括叙利亚其他省份在内的更大群体进行进一步研究，以阐明导致维生素 D 缺乏症的生活方式和社会文化行为风险因素。
{"title":"Distribution of Vitamin D Status in a Group from Syrian Society","authors":"Talleh Almelli","doi":"10.35516/jjps.v16i4.786","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.786","url":null,"abstract":"Objective: The aim of this work is to study the serum levels of 25-hydroxyvitamin D3 in a sample of healthy Syrians in the city of Homs. Method: A cross-sectional study, including 690 ostensibly healthy participants, was conducted at the National Hospital of Homs. Serum levels of 25-hydroxyvitamin D3 were measured using chemiluminescent immunoassay. Results: The overall prevalence of vitamin D inadequacy (insufficiency, deficiency, and severe deficiency) in the study samples was 76.5%. Additionally, 49% of the samples had vitamin D deficiency, with 18.5% suffering from severe deficiency. Furthermore, levels of 25-hydroxyvitamin D3 in females were lower than in males (11.3±2.3 ng/ml versus 39.6±11.28 ng/ml, respectively, p < 0.0001). Veiled women had serum levels of vitamin D lower than non-veiled women, 11.3±2.5 ng/ml versus 25.5±3.2 ng/ml, respectively, p < 0.0001. Female gender and clothing style were identified as independent risk factors for vitamin D deficiency. Conclusion: The prevalence of vitamin D deficiency was very common in the study population, despite the sunny weather in Homs city most of the year. Further studies with larger groups, including other Syrian governorates, are needed to elucidate lifestyle and sociocultural behavior risk factors for vitamin D deficiency.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ghaith M Al-Taani, S. Muflih, Rawan H. Alsharedeh, Zaid Altaany
Background: Seasonal influenza is a viral illness associated with significant morbidity and mortality. Objectives: This study aimed to assess preferences for utilizing the seasonal influenza vaccine. Methods: Based on a review of the literature and discussions among the research team, a 37-item survey was created, pretested, and completed by the lay public in Irbid city. The survey assessed knowledge, willingness-to-pay, and beliefs regarding the seasonal influenza vaccine. Participants' willingness-to-pay for the influenza vaccine was determined using contingent valuation with a payment card. Logistic regression analysis was employed to determine predictors associated with willingness-to-pay. Results: A total of 347 responses constituted the study sample. Respondents rated their knowledge about the influenza vaccine as good or excellent (62.5% of the total received responses). Approximately one-half (45.3%) of the respondents were willing to pay 5 JD for the influenza vaccine. It was found that standard of living, living location (city vs. village), and occupation (i.e., employment status) were independent predictors associated with higher willingness-to-pay for the influenza vaccine. Conclusion: The participants were willing to pay a price close to the market price, thus affording the vaccine. Such data can help healthcare decision-makers develop promotive policies to improve vaccine uptake.
{"title":"Knowledge, Willingness to Pay and Beliefs for Seasonal Influenza Vaccination, A Cross-Sectional Study from Jordan","authors":"Ghaith M Al-Taani, S. Muflih, Rawan H. Alsharedeh, Zaid Altaany","doi":"10.35516/jjps.v16i4.607","DOIUrl":"https://doi.org/10.35516/jjps.v16i4.607","url":null,"abstract":"Background: Seasonal influenza is a viral illness associated with significant morbidity and mortality. Objectives: This study aimed to assess preferences for utilizing the seasonal influenza vaccine. Methods: Based on a review of the literature and discussions among the research team, a 37-item survey was created, pretested, and completed by the lay public in Irbid city. The survey assessed knowledge, willingness-to-pay, and beliefs regarding the seasonal influenza vaccine. Participants' willingness-to-pay for the influenza vaccine was determined using contingent valuation with a payment card. Logistic regression analysis was employed to determine predictors associated with willingness-to-pay. Results: A total of 347 responses constituted the study sample. Respondents rated their knowledge about the influenza vaccine as good or excellent (62.5% of the total received responses). Approximately one-half (45.3%) of the respondents were willing to pay 5 JD for the influenza vaccine. It was found that standard of living, living location (city vs. village), and occupation (i.e., employment status) were independent predictors associated with higher willingness-to-pay for the influenza vaccine. Conclusion: The participants were willing to pay a price close to the market price, thus affording the vaccine. Such data can help healthcare decision-makers develop promotive policies to improve vaccine uptake.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Utpal Kumar Karmakar, Animesh Paul, Pritam Kundu, Progga Paramita Paul
Flagellaria indica (Family: Flagellariaceae) is a common climbing plant found primarily in tropical regions of many countries. The plant has various traditional uses, although most of them lack scientific published reports. The crude ethanolic extract of F. indica leaves was fractionated based on polarity using water, ethyl acetate, and n-hexane. Biological screening was conducted on the anthelmintic, blood coagulation, diuretic, and laxative activities of the water, ethyl acetate, and n-hexane fractions of F. indica leaves. In the anthelmintic test, the n-hexane fraction showed a moderate effect with paralysis times of 16.79 and 13.62 minutes and death times of 27.34 and 21.81 minutes, respectively, at doses of 25 and 50 mg/mL.In the blood coagulant test, only the water fraction showed a notable effect. The clotting times were 4.33, 6.02, 7.68, and 8.32 minutes, respectively, at doses of 200, 100, 50, and 25 mg/mL. Diuretic activity was performed to determine the increase in the volume of excreted urine, and electrolyte analysis of urine was performed to determine pH, density, conductance, and Na+, Cl-, K+ levels, as well as natriuretic, kaliuretic, saluretic, and CAI indexes. The ethyl acetate fraction showed better diuretic activity than the n-hexane fraction, while the water fraction did not reveal a notable diuretic effect. The Na+, Cl-, K+, natriuretic, and saluretic indexes were found satisfactory in the ethyl acetate fraction, and the CAI index was better in the n-hexane fraction. In the laxative test, the n-hexane fraction showed the best laxative properties, with an increase in stool weight of 38% and 54% at doses of 250 and 500 mg/kg, respectively. These results suggest that different fractions of F. indica leaves contain distinct phytochemicals that may be responsible for these biological effects. The isolation of bioactive compounds could help justify its traditional uses in modern medicine.
{"title":"Exploration of Anthelmintic, Blood Coagulant, Diuretic and Laxative Activities of Different Solvent Fractions of Flagellaria Indica Leaves","authors":"Utpal Kumar Karmakar, Animesh Paul, Pritam Kundu, Progga Paramita Paul","doi":"10.35516/jjps.v16i3.976","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.976","url":null,"abstract":"Flagellaria indica (Family: Flagellariaceae) is a common climbing plant found primarily in tropical regions of many countries. The plant has various traditional uses, although most of them lack scientific published reports. The crude ethanolic extract of F. indica leaves was fractionated based on polarity using water, ethyl acetate, and n-hexane. Biological screening was conducted on the anthelmintic, blood coagulation, diuretic, and laxative activities of the water, ethyl acetate, and n-hexane fractions of F. indica leaves. In the anthelmintic test, the n-hexane fraction showed a moderate effect with paralysis times of 16.79 and 13.62 minutes and death times of 27.34 and 21.81 minutes, respectively, at doses of 25 and 50 mg/mL.In the blood coagulant test, only the water fraction showed a notable effect. The clotting times were 4.33, 6.02, 7.68, and 8.32 minutes, respectively, at doses of 200, 100, 50, and 25 mg/mL. Diuretic activity was performed to determine the increase in the volume of excreted urine, and electrolyte analysis of urine was performed to determine pH, density, conductance, and Na+, Cl-, K+ levels, as well as natriuretic, kaliuretic, saluretic, and CAI indexes. The ethyl acetate fraction showed better diuretic activity than the n-hexane fraction, while the water fraction did not reveal a notable diuretic effect. The Na+, Cl-, K+, natriuretic, and saluretic indexes were found satisfactory in the ethyl acetate fraction, and the CAI index was better in the n-hexane fraction. In the laxative test, the n-hexane fraction showed the best laxative properties, with an increase in stool weight of 38% and 54% at doses of 250 and 500 mg/kg, respectively. These results suggest that different fractions of F. indica leaves contain distinct phytochemicals that may be responsible for these biological effects. The isolation of bioactive compounds could help justify its traditional uses in modern medicine.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135965494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Aim: The stress induced by surgery disrupts the delicate balance between hepatic glucose production and glucose utilization in the body. Despite the significance of intraoperative glycaemic control for diabetic patients, limited attention has been given to this aspect. Two methods for administering insulin to manage glucose levels during surgery exist. This study aimed to compare intraoperative glucose levels in diabetic patients undergoing Coronary Artery Bypass Graft (CABG) surgery using either insulin infusion or the bolus method. Method: This was a Randomized Clinical Trial (RCT). Seventy diabetic patients aged 40 or older scheduled for CABG surgery were enrolled in the trial. They were randomly assigned, using block randomization, to receive intraoperative insulin via either infusion or the bolus method. The primary outcome measure was intraoperative glucose levels. Subsequent insulin unit requirements and intraoperative potassium levels were secondary outcomes. Data was monitored throughout the CABG procedure and recorded at six different checkpoints. Results: Male patients constituted the majority in both groups, with no significant differences in the preoperative characteristics of patients, including HbA1c levels and comorbidities. The infusion regimen demonstrated a statistically significant reduction in glucose levels (-19.12 mg/dL, 95% CI: -27.68 to -10.55, P<0.001, Cohen's d=1.06) compared to the bolus regimen. The total insulin units administered in the infusion group were 480 units, as opposed to 600 units in the bolus group (P=0.001, Cohen's d=0.85). Importantly, no cases of hypoglycemia or hyperkalemia were reported among the patients. Conclusion: Intraoperative glucose control using insulin was effective for CABG patients with diabetes. However, the infusion regimen exhibited statistically superior results compared to the bolus regimen. Clinical Trials Registry and Registration Number: The trial received approval from the Ethics Committee on 2/1/2019/2020 and was registered on Clinicaltrials.gov under ID: NCT04824586.
{"title":"Intraoperative Insulin Infusion Regimen versus Insulin Bolus Regimen for Glucose Management during CABG Surgery: A Randomized Clinical Trial","authors":"Rami Alqassieh, Mohanad Odeh, Feras Jirjees","doi":"10.35516/jjps.v16i3.708","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.708","url":null,"abstract":"Background and Aim: The stress induced by surgery disrupts the delicate balance between hepatic glucose production and glucose utilization in the body. Despite the significance of intraoperative glycaemic control for diabetic patients, limited attention has been given to this aspect. Two methods for administering insulin to manage glucose levels during surgery exist. This study aimed to compare intraoperative glucose levels in diabetic patients undergoing Coronary Artery Bypass Graft (CABG) surgery using either insulin infusion or the bolus method. Method: This was a Randomized Clinical Trial (RCT). Seventy diabetic patients aged 40 or older scheduled for CABG surgery were enrolled in the trial. They were randomly assigned, using block randomization, to receive intraoperative insulin via either infusion or the bolus method. The primary outcome measure was intraoperative glucose levels. Subsequent insulin unit requirements and intraoperative potassium levels were secondary outcomes. Data was monitored throughout the CABG procedure and recorded at six different checkpoints. Results: Male patients constituted the majority in both groups, with no significant differences in the preoperative characteristics of patients, including HbA1c levels and comorbidities. The infusion regimen demonstrated a statistically significant reduction in glucose levels (-19.12 mg/dL, 95% CI: -27.68 to -10.55, P<0.001, Cohen's d=1.06) compared to the bolus regimen. The total insulin units administered in the infusion group were 480 units, as opposed to 600 units in the bolus group (P=0.001, Cohen's d=0.85). Importantly, no cases of hypoglycemia or hyperkalemia were reported among the patients. Conclusion: Intraoperative glucose control using insulin was effective for CABG patients with diabetes. However, the infusion regimen exhibited statistically superior results compared to the bolus regimen. Clinical Trials Registry and Registration Number: The trial received approval from the Ethics Committee on 2/1/2019/2020 and was registered on Clinicaltrials.gov under ID: NCT04824586.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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