Background: Pharmacists' knowledge of medication risks and benefits during pregnancy, as well as their competence in making appropriate therapeutic decisions to optimize medication use among pregnant women, is crucial. This study aims to evaluate the knowledge of Jordanian pharmacists regarding medication risks and safety during pregnancy and assess their abilities to make appropriate therapeutic decisions and optimize medication use. Methods: A self-administered questionnaire was sent to 400 randomly selected pharmacists practicing in Amman, Jordan. A validated questionnaire, consisting of six sections with predefined options, was employed. Results: A total of 233 pharmacists completed the questionnaire, resulting in a response rate of 58.2%. Nearly 73.4% of pharmacists (N = 171) correctly identified the drug of choice for hypertension during pregnancy. Over 70% of pharmacists (N = 169) determined the correct dose of aspirin to prevent preeclampsia. About 50% of pharmacists exhibited limited knowledge regarding drug risks and safety during pregnancy. There was a significant difference in the pharmacists' scores on all tests based on their marital status and years of experience (p = 0.04 and p = 0.01, respectively). Among pharmacists, 79.8% stated that they studied pharmacotherapy during pregnancy in their undergraduate courses. Conclusion: Pharmacists have demonstrated an inadequate level of preparedness in providing appropriate pharmaceutical care for pregnant women. Therefore, there is an urgent need to collaborate between national health authorities and academic institutions to empower pharmacists and enhance their knowledge and skills necessary to improve the health outcomes of pregnant women.
{"title":"Evaluation of Pharmacotherapy Standards During Pregnancy Among Jordanian Pharmacy Colleges Graduates","authors":"Rajaa Daghash, Munim A. Al-Saaideh, Rania Itani","doi":"10.35516/jjps.v16i3.972","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.972","url":null,"abstract":"Background: Pharmacists' knowledge of medication risks and benefits during pregnancy, as well as their competence in making appropriate therapeutic decisions to optimize medication use among pregnant women, is crucial. This study aims to evaluate the knowledge of Jordanian pharmacists regarding medication risks and safety during pregnancy and assess their abilities to make appropriate therapeutic decisions and optimize medication use. Methods: A self-administered questionnaire was sent to 400 randomly selected pharmacists practicing in Amman, Jordan. A validated questionnaire, consisting of six sections with predefined options, was employed. Results: A total of 233 pharmacists completed the questionnaire, resulting in a response rate of 58.2%. Nearly 73.4% of pharmacists (N = 171) correctly identified the drug of choice for hypertension during pregnancy. Over 70% of pharmacists (N = 169) determined the correct dose of aspirin to prevent preeclampsia. About 50% of pharmacists exhibited limited knowledge regarding drug risks and safety during pregnancy. There was a significant difference in the pharmacists' scores on all tests based on their marital status and years of experience (p = 0.04 and p = 0.01, respectively). Among pharmacists, 79.8% stated that they studied pharmacotherapy during pregnancy in their undergraduate courses. Conclusion: Pharmacists have demonstrated an inadequate level of preparedness in providing appropriate pharmaceutical care for pregnant women. Therefore, there is an urgent need to collaborate between national health authorities and academic institutions to empower pharmacists and enhance their knowledge and skills necessary to improve the health outcomes of pregnant women.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gleb Zyuz`kov, Yuliya Zyuz`Kova, Olga Bryushinina, Nataliya Abdrashitova, Alexandr Lakeev, Darya Tsuran, Galina Frelikh, Vladimir Udut
The effect of the c-Jun N-terminal kinases (JNK) inhibitor 'IQ-1' on the pharmacokinetics of the antidepressant venlafaxine was studied. An acceleration of the metabolism of this psychotropic agent was revealed when a modifier of intracellular signal transduction was administered to experimental animals in vivo. The JNK blockade was accompanied by a decrease in the plasma level of the antidepressant without changes in the concentration of the pharmacologically active metabolite O-desmethylvenlafaxine. The results obtained indicate a modification of the pattern of venlafaxine biotransformation, involving a change in metabolic pathways with an increase in the formation of other metabolites, or a correction of its distribution in the body. The revealed properties of the JNK inhibitor can be used to develop fundamentally new approaches to improve the effectiveness of antidepressant therapy with venlafaxine within the framework of implementing the 'Strategy for Targeted Regulation of Xenobiotic Metabolism and Drug Pharmacokinetics'.
研究了c-Jun n -末端激酶(JNK)抑制剂IQ-1对抗抑郁药文拉法辛药动学的影响。当一种细胞内信号转导调节剂被施用于实验动物体内时，发现这种精神药物的代谢加速。JNK阻断伴随着血浆抗抑郁药水平的下降，而药理活性代谢物o -去甲基文拉法辛的浓度没有变化。所获得的结果表明，文拉法辛生物转化模式的改变，涉及代谢途径的改变，其他代谢物的形成增加，或其在体内分布的纠正。JNK抑制剂所揭示的特性可用于在实施“外源代谢和药物药代动力学靶向调节策略”的框架内开发新的方法，以提高文拉法辛抗抑郁治疗的有效性。
{"title":"C-Jun N-Terminal Kinases Inhibition: A New Approach to the Regulation of Venlafaxine Pharmacokinetics","authors":"Gleb Zyuz`kov, Yuliya Zyuz`Kova, Olga Bryushinina, Nataliya Abdrashitova, Alexandr Lakeev, Darya Tsuran, Galina Frelikh, Vladimir Udut","doi":"10.35516/jjps.v16i3.718","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.718","url":null,"abstract":"The effect of the c-Jun N-terminal kinases (JNK) inhibitor 'IQ-1' on the pharmacokinetics of the antidepressant venlafaxine was studied. An acceleration of the metabolism of this psychotropic agent was revealed when a modifier of intracellular signal transduction was administered to experimental animals in vivo. The JNK blockade was accompanied by a decrease in the plasma level of the antidepressant without changes in the concentration of the pharmacologically active metabolite O-desmethylvenlafaxine. The results obtained indicate a modification of the pattern of venlafaxine biotransformation, involving a change in metabolic pathways with an increase in the formation of other metabolites, or a correction of its distribution in the body. The revealed properties of the JNK inhibitor can be used to develop fundamentally new approaches to improve the effectiveness of antidepressant therapy with venlafaxine within the framework of implementing the 'Strategy for Targeted Regulation of Xenobiotic Metabolism and Drug Pharmacokinetics'.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zainab Lafi, Walhan Alshaer, Ma’mon M. Hatmal, Malek A. Zihlif, Nisreen Y. Asha, Hiba Abdelnabi, Abdullah Awidi
Echinomycin is a natural compound discovered and isolated from bacteria, introduced as a promising antibiotic and anticancer therapy. However, it failed clinically due to improper formulations and a short half-life. After the unsuccessful clinical trials, echinomycin was overlooked. Recently, a new mechanism of action has given some hope for reviving echinomycin as an inhibitor of hypoxia-inducible factor (HIF-1). In 2015, echinomycin received orphan drug designation for treating acute myeloid leukemia in the USA. Furthermore, advancements in drug delivery systems have provided new prospects to overcome the echinomycin formulation issues and explore further therapeutic benefits. This review details the echinomycin journey along with the main challenges of this potent drug and provides insights into possible future clinical applications.
{"title":"Echinomycin: A Journey of Challenges","authors":"Zainab Lafi, Walhan Alshaer, Ma’mon M. Hatmal, Malek A. Zihlif, Nisreen Y. Asha, Hiba Abdelnabi, Abdullah Awidi","doi":"10.35516/jjps.v16i3.918","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.918","url":null,"abstract":"Echinomycin is a natural compound discovered and isolated from bacteria, introduced as a promising antibiotic and anticancer therapy. However, it failed clinically due to improper formulations and a short half-life. After the unsuccessful clinical trials, echinomycin was overlooked. Recently, a new mechanism of action has given some hope for reviving echinomycin as an inhibitor of hypoxia-inducible factor (HIF-1). In 2015, echinomycin received orphan drug designation for treating acute myeloid leukemia in the USA. Furthermore, advancements in drug delivery systems have provided new prospects to overcome the echinomycin formulation issues and explore further therapeutic benefits. This review details the echinomycin journey along with the main challenges of this potent drug and provides insights into possible future clinical applications.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.35516/jjps.v16i2.1542
W. Al-Qerem, Mohammad Safar, I. Sáfár, Mahmood Al-Ibadah
Coronavirus 2019 (Covid-19) is a serious infectious disease that affects humans globally. Identifying factors that increase the prevalence of mortality are of interest for the healthcare providers. Therefore, the present study aimed to evaluate many risk factors and its association with mortality among COVID-19 patients. A total of 353 patients enrolled in this multicentered case-controlled retrospective study that was conducted in two designated hospitals in Amman, Jordan on patients admitted between 25 October 2020 to 26 September 2021. According to a stepwise binary logistic regression analysis found that patients who took Meropenem (p<0.001) and beta blockers (p=0.004) had lower incidence to be discharge during hospitalization. Also, diabetic patients (p<0.001) had lower discharge rate. We concluded that patients with secondary bacterial infection during the course of hospitalization, patients who needed to take beta blockers and diabetic patients are at higher risk of mortality.
{"title":"Identifying factors associated with increased rate of mortality of COVID-19 patients among Jordanian population: A multicenter case-controlled retrospective study","authors":"W. Al-Qerem, Mohammad Safar, I. Sáfár, Mahmood Al-Ibadah","doi":"10.35516/jjps.v16i2.1542","DOIUrl":"https://doi.org/10.35516/jjps.v16i2.1542","url":null,"abstract":"Coronavirus 2019 (Covid-19) is a serious infectious disease that affects humans globally. Identifying factors that increase the prevalence of mortality are of interest for the healthcare providers. Therefore, the present study aimed to evaluate many risk factors and its association with mortality among COVID-19 patients. \u0000A total of 353 patients enrolled in this multicentered case-controlled retrospective study that was conducted in two designated hospitals in Amman, Jordan on patients admitted between 25 October 2020 to 26 September 2021. According to a stepwise binary logistic regression analysis found that patients who took Meropenem (p<0.001) and beta blockers (p=0.004) had lower incidence to be discharge during hospitalization. Also, diabetic patients (p<0.001) had lower discharge rate. We concluded that patients with secondary bacterial infection during the course of hospitalization, patients who needed to take beta blockers and diabetic patients are at higher risk of mortality.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49147974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.35516/jjps.v16i2.1528
Arij Fouzat Hassan, Ashraf Khalil, A. Al Moustafa
Elaeagnus angustifolia (EA) is a traditional plant that has been used as an alternative medicine for centuries. EA roles as anti-cancer has been investigated against different types of cancer, however, its effect against human cancer has not been investigated yet. Therefore, we investigated the aqueous EA extract effect on colorectal cancer (CRC) cell lines (HCT-116 and LoVo) and examined its underlying mechanisms of action in vitro. Our results showed that EA inhibited cell proliferation and disturbed cell-cycle progression of both CRC cell lines comparing to the control. Moreover, EA extract significantly reduced colony formation in addition to migration and invasion ability of both CRC cell lines this is confirmed by significant upregulation of E-cadherin and Pan-cadherin as well as down regulation of Vimentin. Further, β-catenin/JNK signaling pathway was analyzed and we found that EA extract significantly blocked the activity of total and phosphorylated β-catenin and JNK1/2/3.
{"title":"Elaeagnus Angustifolia Plant Extract inhibits Epithelial- mesenchymal Transition in Human Colorectal Cancer via β-catenin/JNK signaling Pathways","authors":"Arij Fouzat Hassan, Ashraf Khalil, A. Al Moustafa","doi":"10.35516/jjps.v16i2.1528","DOIUrl":"https://doi.org/10.35516/jjps.v16i2.1528","url":null,"abstract":"Elaeagnus angustifolia (EA) is a traditional plant that has been used as an alternative medicine for centuries. EA roles as anti-cancer has been investigated against different types of cancer, however, its effect against human cancer has not been investigated yet. Therefore, we investigated the aqueous EA extract effect on colorectal cancer (CRC) cell lines (HCT-116 and LoVo) and examined its underlying mechanisms of action in vitro. Our results showed that EA inhibited cell proliferation and disturbed cell-cycle progression of both CRC cell lines comparing to the control. Moreover, EA extract significantly reduced colony formation in addition to migration and invasion ability of both CRC cell lines this is confirmed by significant upregulation of E-cadherin and Pan-cadherin as well as down regulation of Vimentin. Further, β-catenin/JNK signaling pathway was analyzed and we found that EA extract significantly blocked the activity of total and phosphorylated β-catenin and JNK1/2/3.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48220824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.35516/jjps.v16i2.1494
A. Abu Taha
Background: Urinary tract infection (UTI) is the most common infection in the community. The causative agents and antibiotic resistance differ between community-acquired and hospital-acquired urinary tract infections. Objectives: This study aimed at identifying the etiologic agents in both community-acquired as well as hospital-acquired urinary tract infections and to determine the antibiotic resistance pattern of the most frequent organisms. Methods: This is a retrospective cross sectional study of positive urine cultures of adult patients attending An-Najah National University Hospital (NNUH) between the period of Jan 2019 and Dec 2020. Each patient’s age, sex, and urine culture results were obtained from the microbiology lab of NNUH. Microbiology reports included the isolated microorganisms and their antibiotic susceptibility patterns. Results: A total of 798 patients were included in the study, of which 472 (59.1%) were female. Escherichia coli was the most common uropathogen, accounting for 37.8% of the CAUTI and 25.1% of the HAUTI. In CAUTI, E. coli was followed by E. faecalis (16.4%), Klebsiella pneumoniae (13.7%), E. faecium (6.5%), and Streptococcus agalactia (4.9%). Among HAUTIs, the second most common was Klebsiella pneumoniea (21.4%) followed by E. faecium (19.3%), E. faecalis (13.4%), and Pseudomonas aeruginosa (7%). The rates of ESBL-producing strains of E. coli were similar between CAUTI (54.1%) and HAUTI (53.2%). coli from CAUTI and HAUTI was sensitive to carbapenems, amikacin, and nitrofurantoin. The antibiotics with the highest resistance rates were ampicillin, cefuroxime, cotrimoxazole, and ciprofloxacin. Resistance rates were higher in HAUTI than in CAUTI. Conclusions: The UTI etiological profiles and antibiotic resistance patterns varied between CAUTI and HAUTI; thus, a different antibiotic therapy for various categories should be considered when initiating empirical antimicrobial therapies.
{"title":"Spectrum and Antibiotic Resistance in the Community and Hospital-Acquired Urinary Tract Infected Adults","authors":"A. Abu Taha","doi":"10.35516/jjps.v16i2.1494","DOIUrl":"https://doi.org/10.35516/jjps.v16i2.1494","url":null,"abstract":"Background: Urinary tract infection (UTI) is the most common infection in the community. The causative agents and antibiotic resistance differ between community-acquired and hospital-acquired urinary tract infections. \u0000Objectives: This study aimed at identifying the etiologic agents in both community-acquired as well as hospital-acquired urinary tract infections and to determine the antibiotic resistance pattern of the most frequent organisms. \u0000Methods: This is a retrospective cross sectional study of positive urine cultures of adult patients attending An-Najah National University Hospital (NNUH) between the period of Jan 2019 and Dec 2020. \u0000Each patient’s age, sex, and urine culture results were obtained from the microbiology lab of NNUH. Microbiology reports included the isolated microorganisms and their antibiotic susceptibility patterns. \u0000Results: A total of 798 patients were included in the study, of which 472 (59.1%) were female. Escherichia coli was the most common uropathogen, accounting for 37.8% of the CAUTI and 25.1% of the HAUTI. In CAUTI, E. coli was followed by E. faecalis (16.4%), Klebsiella pneumoniae (13.7%), E. faecium (6.5%), and Streptococcus agalactia (4.9%). Among HAUTIs, the second most common was Klebsiella pneumoniea (21.4%) followed by E. faecium (19.3%), E. faecalis (13.4%), and Pseudomonas aeruginosa (7%). The rates of ESBL-producing strains of E. coli were similar between CAUTI (54.1%) and HAUTI (53.2%). \u0000 \u0000 coli from CAUTI and HAUTI was sensitive to carbapenems, amikacin, and nitrofurantoin. The antibiotics with the highest resistance rates were ampicillin, cefuroxime, cotrimoxazole, and ciprofloxacin. Resistance rates were higher in HAUTI than in CAUTI. \u0000 \u0000Conclusions: The UTI etiological profiles and antibiotic resistance patterns varied between CAUTI and HAUTI; thus, a different antibiotic therapy for various categories should be considered when initiating empirical antimicrobial therapies.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47325486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.35516/jjps.v16i2.1493
S. Hattab, S. Zyoud, Bashar Saleh, Laith Qasarweh, Mahmoud Draidi
Background: Androgenic-anabolic steroids (AAS) use has increased in the last years, especially among athletes, due to their effect on body shape and performance. These agents could have serious side effects among this highly susciptable population. Methods: Cross-sectional study that included physical education students at An-Najah National University over the period of November 2020 to January 2021, using an electronic questionnaire. The main outcome was to measure the level of knowledge and use of AAS. Results: A total of 380 students were included. The mean age of the students was 21 years (SD= 4.2), and study participants were distributed almost equally according to sex. About one fourth of the students were smokers. Eighty percent of the study participants are from West Bank while the remaining 20 % are from Jerusalem and 48 territories. Furthermore, most of the students live with their families, half of them live in cities, while about 40% live in villages and only 8% in camps. The average level of knowledge about AAS was 2.95 over 8 (37/100) with a median of three. Furthermore, only 36 (10%) participants had satisfactory knowledge, scoring 80% or more. Regarding the use of AAS, eleven participants (2.9%), all males, confirmed that they are currently using AAS. Additionally, about 28 (7%) had previously used them while 30 (8%) are planning to try them in the future. Overall, 221(58%) confirmed using vitamins and minerals. Conclusion: Our study showed that the majority of participants have a substantial lack of information regarding the potential side-effects of AAS while the level of use is comparable with other populations.
{"title":"Level of Knowledge and Extent of Use of Anabolic-Androgenic Steroids among Physical Education University Students: A Cross-Sectional Study from Palestine","authors":"S. Hattab, S. Zyoud, Bashar Saleh, Laith Qasarweh, Mahmoud Draidi","doi":"10.35516/jjps.v16i2.1493","DOIUrl":"https://doi.org/10.35516/jjps.v16i2.1493","url":null,"abstract":"Background: Androgenic-anabolic steroids (AAS) use has increased in the last years, especially among athletes, due to their effect on body shape and performance. These agents could have serious side effects among this highly susciptable population. \u0000Methods: Cross-sectional study that included physical education students at An-Najah National University over the period of November 2020 to January 2021, using an electronic questionnaire. The main outcome was to measure the level of knowledge and use of AAS. \u0000Results: A total of 380 students were included. The mean age of the students was 21 years (SD= 4.2), and study participants were distributed almost equally according to sex. About one fourth of the students were smokers. Eighty percent of the study participants are from West Bank while the remaining 20 % are from Jerusalem and 48 territories. Furthermore, most of the students live with their families, half of them live in cities, while about 40% live in villages and only 8% in camps. The average level of knowledge about AAS was 2.95 over 8 (37/100) with a median of three. Furthermore, only 36 (10%) participants had satisfactory knowledge, scoring 80% or more. Regarding the use of AAS, eleven participants (2.9%), all males, confirmed that they are currently using AAS. Additionally, about 28 (7%) had previously used them while 30 (8%) are planning to try them in the future. Overall, 221(58%) confirmed using vitamins and minerals. \u0000Conclusion: Our study showed that the majority of participants have a substantial lack of information regarding the potential side-effects of AAS while the level of use is comparable with other populations.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43638195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.35516/jjps.v16i2.1466
Ala A. Alhusban, Samah A. Ata, Lama A. Hamadneh, O. Tarawneh, Haneen Abuzaid, Sokiyna Albustanji, Mohammad K. Awad
The rate of smokers in Jordan has been among the highest globally. Electronic Nicotine Delivery systems (ENDs) are considered helpful in smoking cessation but also have the potential for metals exposure resulting from their transfer from the metallic coils to the e-liquid upon use. Metal exposure is associated with severe health outcomes. We sought to assess the levels of toxic metals (Cr, Cd, Pb, Ni and Al) transfer from two of the most popular coils used in ENDs among users in Jordan. The validated inductively coupled plasma-optical emission spectroscopy (ICP-OES) with limit of detections (LODs) of 0.10, 0.90, 0.15, 0.13 and 1.00 mg.kg−1 was employed to measure the levels of toxic metals in the e-liquid samples. Following a repetitive usage of coils in both tank and pod systems for five continuous days, the cumulative amount of toxic metals; Ni, Cr, Al and Pb levels were significantly increased in all e-liquids used (p < 0.0001) compared to the fresh unheated samples. The obtained results showed a time-dependent increase of metals transfer from coils to e-liquids, thus highlighting the need for additional studies to re-assess the safety claims of using ENDs for smoking cessation.
{"title":"Toxic Metals Transfer from Heating Coils to e-liquids: Safety Assessment of Popular e-cigarettes in Jordan","authors":"Ala A. Alhusban, Samah A. Ata, Lama A. Hamadneh, O. Tarawneh, Haneen Abuzaid, Sokiyna Albustanji, Mohammad K. Awad","doi":"10.35516/jjps.v16i2.1466","DOIUrl":"https://doi.org/10.35516/jjps.v16i2.1466","url":null,"abstract":"The rate of smokers in Jordan has been among the highest globally. Electronic Nicotine Delivery systems (ENDs) are considered helpful in smoking cessation but also have the potential for metals exposure resulting from their transfer from the metallic coils to the e-liquid upon use. Metal exposure is associated with severe health outcomes. We sought to assess the levels of toxic metals (Cr, Cd, Pb, Ni and Al) transfer from two of the most popular coils used in ENDs among users in Jordan. The validated inductively coupled plasma-optical emission spectroscopy (ICP-OES) with limit of detections (LODs) of 0.10, 0.90, 0.15, 0.13 and 1.00 mg.kg−1 was employed to measure the levels of toxic metals in the e-liquid samples. Following a repetitive usage of coils in both tank and pod systems for five continuous days, the cumulative amount of toxic metals; Ni, Cr, Al and Pb levels were significantly increased in all e-liquids used (p < 0.0001) compared to the fresh unheated samples. The obtained results showed a time-dependent increase of metals transfer from coils to e-liquids, thus highlighting the need for additional studies to re-assess the safety claims of using ENDs for smoking cessation. \u0000 ","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43839576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.35516/jjps.v16i2.1463
Worood H Ismail, Osama H. Abusara, Balqis A. Ikhmais, Hassan Abul‐Futouh, Suhair Sunoqrot, Ali I. M. Ibrahim
Natural products are known to exhibit antimicrobial, anticancer, and antioxidant activities. Among these natural products is cinnamon which contains cinnamaldehyde. Cinnamaldehyde and its derivatives have been reported to have anticancer and antioxidant activities. Coniferyl aldehyde, a non-cytotoxic compound and a cinnamaldehyde derivative, has also been shown to have anticancer activity. In this study, several derivatives of coniferyl aldehyde were synthesized and evaluated for their anticancer and antioxidant activities. Compounds 1, 2, 4, and 8-11 showed cytotoxic activity against H1299 cell line, a non-small cell lung cancer cells, with 4 being the most potent with IC50 value of 6.7 μM. The antioxidant assay experiment showed that compounds 1, 2, and 4 resulted in half the scavenging activity of vitamin C at all tested concentrations. The coniferyl aldehyde itself showed dose-dependent antioxidant activity, with a proposed free radical stabilization mechanism. Thus, our study showed that the synthesized coniferyl aldehyde derivatives exhibit anticancer and antioxidant activities, which might act as potential therapeutic agents.
{"title":"Design, Synthesis, and Biological Activity of Coniferyl Aldehyde Derivatives as Potential Anticancer and Antioxidant Agents","authors":"Worood H Ismail, Osama H. Abusara, Balqis A. Ikhmais, Hassan Abul‐Futouh, Suhair Sunoqrot, Ali I. M. Ibrahim","doi":"10.35516/jjps.v16i2.1463","DOIUrl":"https://doi.org/10.35516/jjps.v16i2.1463","url":null,"abstract":"Natural products are known to exhibit antimicrobial, anticancer, and antioxidant activities. Among these natural products is cinnamon which contains cinnamaldehyde. Cinnamaldehyde and its derivatives have been reported to have anticancer and antioxidant activities. Coniferyl aldehyde, a non-cytotoxic compound and a cinnamaldehyde derivative, has also been shown to have anticancer activity. In this study, several derivatives of coniferyl aldehyde were synthesized and evaluated for their anticancer and antioxidant activities. Compounds 1, 2, 4, and 8-11 showed cytotoxic activity against H1299 cell line, a non-small cell lung cancer cells, with 4 being the most potent with IC50 value of 6.7 μM. The antioxidant assay experiment showed that compounds 1, 2, and 4 resulted in half the scavenging activity of vitamin C at all tested concentrations. The coniferyl aldehyde itself showed dose-dependent antioxidant activity, with a proposed free radical stabilization mechanism. Thus, our study showed that the synthesized coniferyl aldehyde derivatives exhibit anticancer and antioxidant activities, which might act as potential therapeutic agents.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47051175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.35516/jjps.v16i2.1490
Ahmad Al-Rusasi
Background information: Pharmacy is a longstanding profession, although there have been changes in pharmacists’ roles over time. The change toward a patient-centered approach is recognized as an entirely different concept from the technical concept of dispensing. The pharmacist’s natural attitude primarily relies on pharmacologic knowledge of medications, the product, the use of counseling as the major approach with patients, and an emphasis on medication adherence as a goal. Though, besides a pharmacologic understanding, the knowledge of the patient and the knowledge of the experience of the patient, from his or her own perspective, are essential to help the pharmacist assess and ensure that a medication is indicated, effective, safe, and convenient. Therefore, to be able to work with patients in a patient-centered manner, the pharmacist must acknowledge a broader scope of knowledge that will account for a more comprehensive approach. Conclusion: To practice in a truly patient-centered manner, pharmacist must understand that patients want to be heard and seen as individuals with unique experiences and responses to medications. This knowledge is needed to enhance pharmacists’ basic pharmacotherapeutic understanding and provide for care of patients as individuals with unique experiences and stories and situated in community, culture, and society. Likewise, to help patients with their medications, pharmacist must begin to understand medications as patients experience them. This includes understanding their experiences with illness as well as their feelings about medications.
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