Pub Date : 2023-09-23DOI: 10.35516/jjps.v16i3.1609
Muhammad Hermawan Widyananda, Coni Anggie Kurniasari, Fajar Mustika Alam, Wahyu Choirur Rizky, Tim Godefridus Antonius Dings, Arif Nur Muhammad Ansori, Yulanda Antonius
Boesenbergia rotunda L., commonly known as fingerroot, is recognized as one of Indonesia's medicinal plants with significant potential for treating various diseases, including atherosclerosis. This study aims to analyze the anti-atherosclerosis potential of bioactive compounds found in fingerroot by assessing their inhibitory effects on four proteins associated with atherosclerosis (CETP, ACAT1, OSC, and sPLA2). Bioactive compounds from B. rotunda were retrieved from the KnapSack database. The drug-likeness properties were predicted using the SwissADME web server, and the bioactivity of the compounds was assessed using the PASSOnline server. The identification of active sites on proteins and the validation of protein structures were performed using the SCFBio web server and Autodock Vina. Specific docking simulations between fingerroot compounds and the target proteins were carried out using AutoDock Vina. The analysis revealed that fingerroot contains 20 bioactive compounds with favorable drug-like properties. Among these, dihydrochrysin, sakuranetin, isopimaric acid, 2S-pinocembrin, 5,7-dihydroxy-8-C-geranylflavanone, 7,4'-dihydroxy-5-methoxyflavanone, and 5,7-dihydroxy-8,7-methoxy-5-hydroxy-8-geranylflavanone were predicted to exhibit anti-atherosclerosis activities. In the interactions with CETP, rubranine and (-)-4-hydroxypanduratin A showed the lowest binding affinity scores. Meanwhile, in interactions with ACAT1, OSC, and sPLA2, rubranine and 5,7-dihydroxy-8-C-geranylflavanone displayed the lowest binding affinities. In conclusion, fingerroot exhibits high potential as an anti-atherosclerosis agent through the inhibition of four proteins associated with atherosclerosis, as predicted through in silico analysis.
Boesenbergia rotunda L.，俗称指根，被认为是印度尼西亚的药用植物之一，具有治疗多种疾病的重要潜力，包括动脉粥样硬化。本研究旨在通过评估指根生物活性化合物对四种动脉粥样硬化相关蛋白(CETP、ACAT1、OSC和sPLA2)的抑制作用，分析其抗动脉粥样硬化潜力。从backpack数据库中检索到圆形圆孢杆菌的活性化合物。使用SwissADME web服务器预测药物相似性，使用PASSOnline服务器评估化合物的生物活性。利用SCFBio web服务器和Autodock Vina进行蛋白活性位点的鉴定和蛋白结构的验证。使用AutoDock Vina进行指根化合物与靶蛋白之间的特异性对接模拟。分析表明，指根中含有20种具有良好药理作用的生物活性化合物。其中，二氢菊素、樱素、异海松酸、2s -松皮素、5,7-二羟基-8- c -香叶黄酮、7,4'-二羟基-5-甲氧基黄酮和5,7-二羟基-8,7-甲氧基-5-羟基-8-香叶黄酮被预测具有抗动脉粥样硬化活性。在与CETP的相互作用中，rubranine和(-)-4-hydroxypanduratin A的结合亲和力评分最低。同时，在与ACAT1、OSC和sPLA2的相互作用中，rubranine和5,7-二羟基-8- c -香叶黄酮的结合亲和力最低。总之，手指根通过抑制与动脉粥样硬化相关的四种蛋白质，显示出很高的抗动脉粥样硬化药物的潜力，正如通过硅分析预测的那样。
{"title":"Exploration of Potentially Bioactive Compounds from Fingerroot (Boesenbergia rotunda L.) as Inhibitor of Atherosclerosis-Related Proteins (CETP, ACAT1, OSC, sPLA2): An in silico Study","authors":"Muhammad Hermawan Widyananda, Coni Anggie Kurniasari, Fajar Mustika Alam, Wahyu Choirur Rizky, Tim Godefridus Antonius Dings, Arif Nur Muhammad Ansori, Yulanda Antonius","doi":"10.35516/jjps.v16i3.1609","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.1609","url":null,"abstract":"Boesenbergia rotunda L., commonly known as fingerroot, is recognized as one of Indonesia's medicinal plants with significant potential for treating various diseases, including atherosclerosis. This study aims to analyze the anti-atherosclerosis potential of bioactive compounds found in fingerroot by assessing their inhibitory effects on four proteins associated with atherosclerosis (CETP, ACAT1, OSC, and sPLA2). Bioactive compounds from B. rotunda were retrieved from the KnapSack database. The drug-likeness properties were predicted using the SwissADME web server, and the bioactivity of the compounds was assessed using the PASSOnline server. The identification of active sites on proteins and the validation of protein structures were performed using the SCFBio web server and Autodock Vina. Specific docking simulations between fingerroot compounds and the target proteins were carried out using AutoDock Vina. The analysis revealed that fingerroot contains 20 bioactive compounds with favorable drug-like properties. Among these, dihydrochrysin, sakuranetin, isopimaric acid, 2S-pinocembrin, 5,7-dihydroxy-8-C-geranylflavanone, 7,4'-dihydroxy-5-methoxyflavanone, and 5,7-dihydroxy-8,7-methoxy-5-hydroxy-8-geranylflavanone were predicted to exhibit anti-atherosclerosis activities. In the interactions with CETP, rubranine and (-)-4-hydroxypanduratin A showed the lowest binding affinity scores. Meanwhile, in interactions with ACAT1, OSC, and sPLA2, rubranine and 5,7-dihydroxy-8-C-geranylflavanone displayed the lowest binding affinities. In conclusion, fingerroot exhibits high potential as an anti-atherosclerosis agent through the inhibition of four proteins associated with atherosclerosis, as predicted through in silico analysis.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-23DOI: 10.35516/jjps.v16i3.1602
Ziyan Muhammad Aqsha, Muhammad Alsyifaa Dharmawan, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Nur Imaniati Sumantri
Nipah virus (NiV) is an RNA virus, a pathogenic paramyxovirus that causes nonlethal respiratory illness in pigs. It was originally reported in Malaysia in 1998. NiV is considered a potential outbreak threat because it is zoonotic. However, no vaccines or antiviral drugs have been found against NiV. Therefore, the main objective is to develop effective vaccines by characterizing the fusion protein of NiV. We used a reference sequence retrieved from the National Center for Biotechnology Information (NCBI), then 3D modeled it to obtain the conserved region of the fusion protein. The interaction between the conserved region and B-cell receptors has been evaluated through a molecular docking approach. The B-cell epitope was identified using the Immune Epitope Database (IEDB) web server. As a result, we recommend Pep_D FANCISVTCQCQ as an epitope-based peptide vaccine candidate against Nipah virus. Pep D is highly immunogenic and does not cause autoimmune reactions. Pep D has the lowest binding energy for BCR molecular complexes, which can activate the transduction signal and direct B-cell immune response. However, further studies are required for confirmation (in vitro and in vivo).
{"title":"Reverse Vaccinology Analysis of B-cell Epitope against Nipah Virus using Fusion Protein","authors":"Ziyan Muhammad Aqsha, Muhammad Alsyifaa Dharmawan, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Nur Imaniati Sumantri","doi":"10.35516/jjps.v16i3.1602","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.1602","url":null,"abstract":"Nipah virus (NiV) is an RNA virus, a pathogenic paramyxovirus that causes nonlethal respiratory illness in pigs. It was originally reported in Malaysia in 1998. NiV is considered a potential outbreak threat because it is zoonotic. However, no vaccines or antiviral drugs have been found against NiV. Therefore, the main objective is to develop effective vaccines by characterizing the fusion protein of NiV. We used a reference sequence retrieved from the National Center for Biotechnology Information (NCBI), then 3D modeled it to obtain the conserved region of the fusion protein. The interaction between the conserved region and B-cell receptors has been evaluated through a molecular docking approach. The B-cell epitope was identified using the Immune Epitope Database (IEDB) web server. As a result, we recommend Pep_D FANCISVTCQCQ as an epitope-based peptide vaccine candidate against Nipah virus. Pep D is highly immunogenic and does not cause autoimmune reactions. Pep D has the lowest binding energy for BCR molecular complexes, which can activate the transduction signal and direct B-cell immune response. However, further studies are required for confirmation (in vitro and in vivo).","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Using the Theory of Planned Behavior model developed by Ajzen in 1985, the authors assessed the influence of attitude (ATT) toward vitamins, health awareness (HA), perceived behavioral control (PBC), subjective norms (SN), and knowledge of COVID-19 (KN) on the purchasing intention (PI) of vitamins in Kuwait during the COVID-19 pandemic. A total of 587 adults living in Kuwait completed the online survey, which was available in both Arabic and English. The measured variables included health awareness, attitude, knowledge about COVID-19, purchasing intention, perceived behavioral control, and subjective norms. The findings indicate that HA has a significant impact on ATT. Furthermore, the results revealed that HA significantly influences ATT, ATT has a significant influence on PI, KN has a significant influence on ATT, KN has a significant influence on PI, PBC positively influences PI, SN has a significant influence over PI, and SN positively influences PI.
{"title":"Assessing the Influence of the COVID-19 Pandemic on the Purchasing Intention of Vitamins in Kuwait using the Theory of Planned Behavior","authors":"Abrar Ghaith, Manal Echchad, Farah AlHaman, Raneem Al-Shalby","doi":"10.35516/jjps.v16i3.1611","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.1611","url":null,"abstract":"Using the Theory of Planned Behavior model developed by Ajzen in 1985, the authors assessed the influence of attitude (ATT) toward vitamins, health awareness (HA), perceived behavioral control (PBC), subjective norms (SN), and knowledge of COVID-19 (KN) on the purchasing intention (PI) of vitamins in Kuwait during the COVID-19 pandemic. A total of 587 adults living in Kuwait completed the online survey, which was available in both Arabic and English. The measured variables included health awareness, attitude, knowledge about COVID-19, purchasing intention, perceived behavioral control, and subjective norms. The findings indicate that HA has a significant impact on ATT. Furthermore, the results revealed that HA significantly influences ATT, ATT has a significant influence on PI, KN has a significant influence on ATT, KN has a significant influence on PI, PBC positively influences PI, SN has a significant influence over PI, and SN positively influences PI.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of our study is to conduct an ethnobotanical investigation of traditional medicinal plants used by people in El-Oued state, southeast Algeria, for the treatment of liver diseases. We collected data through personal interviews and questionnaires. In total, we conducted interviews with 156 respondents, the majority of whom were aged 50 or older. Our study of medicinal plants used for treating liver diseases led to the discovery of 78 species from 41 families and various genera, including 52% of medicinal plants found in the wild. Approximately 77% of these plants were primarily used in dried form for remedy preparation. The most commonly employed preparation method was decoction. Interestingly, 70% of the participants mentioned Zizyphus lotus (L.) Lam., Silybum marianum L., and Atriplex halimus L. as sources for treating liver illnesses. This investigation revealed that many people in the research region still rely on herbal remedies to treat liver disorders. Moreover, the present study provides valuable ethnobotanical data on medicinal plants, serving as a foundational resource for future extensive research in this field.
{"title":"Therapeutic Potential of Traditional Medicinal Plants from Algeria for Treatment of Liver Diseases","authors":"Djahra Ali Boutlelis, Chrait Sabrina, Benkaddour Mounia, Benkherara Salah, Laib Ibtissam, Benine Chaima","doi":"10.35516/jjps.v16i3.685","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.685","url":null,"abstract":"The objective of our study is to conduct an ethnobotanical investigation of traditional medicinal plants used by people in El-Oued state, southeast Algeria, for the treatment of liver diseases. We collected data through personal interviews and questionnaires. In total, we conducted interviews with 156 respondents, the majority of whom were aged 50 or older. Our study of medicinal plants used for treating liver diseases led to the discovery of 78 species from 41 families and various genera, including 52% of medicinal plants found in the wild. Approximately 77% of these plants were primarily used in dried form for remedy preparation. The most commonly employed preparation method was decoction. Interestingly, 70% of the participants mentioned Zizyphus lotus (L.) Lam., Silybum marianum L., and Atriplex halimus L. as sources for treating liver illnesses. This investigation revealed that many people in the research region still rely on herbal remedies to treat liver disorders. Moreover, the present study provides valuable ethnobotanical data on medicinal plants, serving as a foundational resource for future extensive research in this field.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Argemone mexicana L. (A. mexicana) has traditionally been used to treat hypertension, urinary issues, and constipation. In this study, we assessed the diuretic activity of the ethanolic crude extract of A. mexicana. Methods: Phytochemical tests were conducted using standard reagents and methods widely accepted in the field. The diuretic test was performed in metabolic cages using a mouse model, with furosemide (5 mg/kg) as the standard drug. Molecular docking was carried out in PyRx using Autodock Vina 4.2. To assess the stability of the protein-ligand complexes formed during docking, we conducted molecular dynamics (MD) simulations for the β-amyrin-6PZT protein complex and the furosemide-6PZT protein complex. Various parameters, including RMSD, RMSF, Rg, SASA, and hydrogen bonds, were calculated for all protein-ligand complexes. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides, steroids, terpenoids, saponins, and tannins in the crude extract. The crude extract exhibited significant (p < 0.05) diuretic activity compared to the control group. Furthermore, we detected the presence of electrolytes (Na+, K+, and Cl-) in the urine of mice treated with the crude extract. In the molecular docking study, among the eighteen compounds studied, β-amyrin displayed superior diuretic potential. The results of the molecular dynamics simulation for the β-amyrin-6PZT protein complex indicated good stability, comparable to the reference drug, furosemide. Conclusion: The crude extract of A. mexicana demonstrates significant diuretic effects that could be valuable for edema treatment. The findings from the molecular docking and molecular dynamics simulations suggest the potential for further research in developing a novel drug.
{"title":"Evaluation of Diuretic Property of Argemone mexicana along with Molecular Docking Study","authors":"Pabitra Kumar Sardar, Hiron Saraj Devnath, Nripendra Nath Biswas, Bishwajit Bokshi, Samir Kumar Sadhu","doi":"10.35516/jjps.v16i3.430","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.430","url":null,"abstract":"Background: Argemone mexicana L. (A. mexicana) has traditionally been used to treat hypertension, urinary issues, and constipation. In this study, we assessed the diuretic activity of the ethanolic crude extract of A. mexicana. Methods: Phytochemical tests were conducted using standard reagents and methods widely accepted in the field. The diuretic test was performed in metabolic cages using a mouse model, with furosemide (5 mg/kg) as the standard drug. Molecular docking was carried out in PyRx using Autodock Vina 4.2. To assess the stability of the protein-ligand complexes formed during docking, we conducted molecular dynamics (MD) simulations for the β-amyrin-6PZT protein complex and the furosemide-6PZT protein complex. Various parameters, including RMSD, RMSF, Rg, SASA, and hydrogen bonds, were calculated for all protein-ligand complexes. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides, steroids, terpenoids, saponins, and tannins in the crude extract. The crude extract exhibited significant (p < 0.05) diuretic activity compared to the control group. Furthermore, we detected the presence of electrolytes (Na+, K+, and Cl-) in the urine of mice treated with the crude extract. In the molecular docking study, among the eighteen compounds studied, β-amyrin displayed superior diuretic potential. The results of the molecular dynamics simulation for the β-amyrin-6PZT protein complex indicated good stability, comparable to the reference drug, furosemide. Conclusion: The crude extract of A. mexicana demonstrates significant diuretic effects that could be valuable for edema treatment. The findings from the molecular docking and molecular dynamics simulations suggest the potential for further research in developing a novel drug.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abeer M. ElSayed, Ghena M. Abdel Razek, Abeer E. EL-Hadidy, Sabah H. El Gayed, Omer Sabry
The primary concern was the removal of numerous soil fumigants and nematicides due to their potential risks to human and environmental safety. Fungal pathogens can cause serious diseases in humans and animals. Among these, root-knot nematodes such as Meloidogyne incognita and Tylenchulus semipenetrans pose a significant threat, leading to substantial damage and yield reduction in various economically important plants. Therefore, this study aimed to assess the fungicidal and nematicidal activities of the ethanol extract (EE) and lupeol (L), the major isolates from the aerial parts of Reichardia tingitana L. Roth (Asteraceae), against Aspergillus flavus and plant-parasitic nematodes. Antifungal actions of EE (10-120 ppm) and L (23.4-281.2 µM) were evaluated through in vitro and in vivo growth assays, spore germination inhibition assays, and the efficacy of inhibiting pod and kernel infection. Nematicidal activity of EE and L was tested by preparing cultures containing egg masses of nematode species M. incognita from infected eggplants and T. semipenetrans from infected citrus roots, using concentrations of 2.5, 5, 10, 20, 40, 80, and 120 ppm. Results showed that R. tingitana (EE) and (L) exhibited nematostatic or nematicidal effects on nematode viability, egg hatch in vitro, and development and reproduction in vivo. Lupeol was particularly effective in inhibiting the colonization of A. flavus in peanuts. EE and L demonstrated high toxicity against nematodes in laboratory exposure and were effective in controlling nematode infestation in eggplant roots for 45 days. Improvement in plant growth parameters, including shoot and root length and weights, varied and was proportional to the doses of EE and L treatments. The antifungal and bio-nematicide effects of the ethanol extract from the aerial parts of R. tingitana were superior to those of lupeol, which could be attributed to the synergistic effect of phytochemicals in the ethanol extract. Both EE and L have potential applications as antifungal and bio-nematicide agents.
{"title":"Assessment of the Fungicidal and Nematicidal Potential of Reichardia tingitana (L.) Roth on Phytopathogenic Fungi and Plant Nematode","authors":"Abeer M. ElSayed, Ghena M. Abdel Razek, Abeer E. EL-Hadidy, Sabah H. El Gayed, Omer Sabry","doi":"10.35516/jjps.v16i3.529","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.529","url":null,"abstract":"The primary concern was the removal of numerous soil fumigants and nematicides due to their potential risks to human and environmental safety. Fungal pathogens can cause serious diseases in humans and animals. Among these, root-knot nematodes such as Meloidogyne incognita and Tylenchulus semipenetrans pose a significant threat, leading to substantial damage and yield reduction in various economically important plants. Therefore, this study aimed to assess the fungicidal and nematicidal activities of the ethanol extract (EE) and lupeol (L), the major isolates from the aerial parts of Reichardia tingitana L. Roth (Asteraceae), against Aspergillus flavus and plant-parasitic nematodes. Antifungal actions of EE (10-120 ppm) and L (23.4-281.2 µM) were evaluated through in vitro and in vivo growth assays, spore germination inhibition assays, and the efficacy of inhibiting pod and kernel infection. Nematicidal activity of EE and L was tested by preparing cultures containing egg masses of nematode species M. incognita from infected eggplants and T. semipenetrans from infected citrus roots, using concentrations of 2.5, 5, 10, 20, 40, 80, and 120 ppm. Results showed that R. tingitana (EE) and (L) exhibited nematostatic or nematicidal effects on nematode viability, egg hatch in vitro, and development and reproduction in vivo. Lupeol was particularly effective in inhibiting the colonization of A. flavus in peanuts. EE and L demonstrated high toxicity against nematodes in laboratory exposure and were effective in controlling nematode infestation in eggplant roots for 45 days. Improvement in plant growth parameters, including shoot and root length and weights, varied and was proportional to the doses of EE and L treatments. The antifungal and bio-nematicide effects of the ethanol extract from the aerial parts of R. tingitana were superior to those of lupeol, which could be attributed to the synergistic effect of phytochemicals in the ethanol extract. Both EE and L have potential applications as antifungal and bio-nematicide agents.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to assess the safety profile of adalimumab and its biosimilars for each approved indication by analyzing adverse events (AEs) reported in the FDA Adverse Event Reporting System (FAERS) database. Method: We conducted a retrospective pharmacovigilance analysis of AE reports documented from 2002 to 2022 in the FAERS database. This analysis included descriptive statistics and binary logistic regression analyses. We calculated reporting odds ratios (RORs) with 95% confidence intervals (CI) to investigate safety signals related to the disproportionate reporting of serious AEs for adalimumab and its biosimilars compared to currently available biological products for the same proposed indications. Results: A total of 543,873 AEs related to adalimumab treatment were reported, with 49.8% classified as serious. Hospitalization was the most frequently reported AE. Risk factors associated with serious AEs included age (≥60 years), male sex, and the concurrent use of adalimumab (ROR >1, P<0.05). Adalimumab exhibited a lower risk of serious AEs compared to abatacept, certolizumab, infliximab, or rituximab. Conversely, etanercept and ixekizumab showed lower odds of serious AEs than adalimumab (ROR <1, P<0.05). Conclusion: In summary, these findings suggest that adalimumab has a well-tolerated safety profile for approved indications when compared to currently available biological alternatives.
{"title":"Safety of Adalimumab: An Analysis of the FDA Adverse Event Reporting System (FAERS) Database","authors":"Buthainah Ghanem","doi":"10.35516/jjps.v16i3.629","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.629","url":null,"abstract":"Objective: This study aims to assess the safety profile of adalimumab and its biosimilars for each approved indication by analyzing adverse events (AEs) reported in the FDA Adverse Event Reporting System (FAERS) database. Method: We conducted a retrospective pharmacovigilance analysis of AE reports documented from 2002 to 2022 in the FAERS database. This analysis included descriptive statistics and binary logistic regression analyses. We calculated reporting odds ratios (RORs) with 95% confidence intervals (CI) to investigate safety signals related to the disproportionate reporting of serious AEs for adalimumab and its biosimilars compared to currently available biological products for the same proposed indications. Results: A total of 543,873 AEs related to adalimumab treatment were reported, with 49.8% classified as serious. Hospitalization was the most frequently reported AE. Risk factors associated with serious AEs included age (≥60 years), male sex, and the concurrent use of adalimumab (ROR >1, P<0.05). Adalimumab exhibited a lower risk of serious AEs compared to abatacept, certolizumab, infliximab, or rituximab. Conversely, etanercept and ixekizumab showed lower odds of serious AEs than adalimumab (ROR <1, P<0.05). Conclusion: In summary, these findings suggest that adalimumab has a well-tolerated safety profile for approved indications when compared to currently available biological alternatives.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In children, high blood pressure can develop into hypertension and its consequences during puberty and adulthood. High blood pressure in children is often secondary to other causes, including renal diseases. Nephrolithiasis is one of the causes of secondary hypertension. The extensive use of cephalosporins in hospitals, particularly ceftriaxone, can result in nephrolithiasis. Therefore, the purpose of this study was to assess the relationship between ceftriaxone treatment and elevated blood pressure in children. Method: The research was conducted as a case-control study over an 18-month period from 2018 to 2019. In this study, blood pressure was measured in 111 children aged 3-13 years who were hospitalized at Amir Kabir Hospital in Arak and received ceftriaxone for at least 48 hours. As a control group, 111 children who did not receive ceftriaxone had their blood pressure measured. The blood pressure levels and percentiles of children in the two groups were then compared. Result: In the case and control groups, the mean age was 5.1±1.61 and 6.04±2.4 years, and the mean height was 109.17±10.71 and 114.86±12.95 cm, respectively. A slightly higher mean systolic blood pressure percentile was observed in the case group (65.59±18.17) than in the control group (65.28±14.51) (P=0.112), and the mean diastolic blood pressure percentile was also slightly higher in the case group (58.89±18.88) than in the control group (54.85±19.28) (P=0.317). The difference in diastolic blood pressure was greater than in systolic blood pressure. However, these detected differences were slight and not statistically significant. Conclusion: This study showed no association between blood pressure levels and ceftriaxone treatment in children older than three years who received the medicine for at least 48 hours. However, additional research is suggested, focusing on the effects of the medicine at higher doses and over a longer period of time following administration.
背景:儿童高血压可在青春期和成年期发展为高血压及其后果。儿童高血压通常继发于其他原因，包括肾脏疾病。肾结石是继发性高血压的病因之一。医院广泛使用头孢菌素，特别是头孢曲松，可导致肾结石。因此，本研究的目的是评估头孢曲松治疗与儿童血压升高之间的关系。方法:采用2018 - 2019年18个月的病例对照研究。在这项研究中，测量了在Arak Amir Kabir医院住院并接受头孢曲松治疗至少48小时的111名3-13岁儿童的血压。作为对照组，111名未接受头孢曲松治疗的儿童测量了血压。然后比较两组儿童的血压水平和百分位数。结果:病例组和对照组的平均年龄分别为5.1±1.61岁和6.04±2.4岁，平均身高分别为109.17±10.71和114.86±12.95 cm。病例组收缩压平均值(65.59±18.17)略高于对照组(65.28±14.51)(P=0.112)，舒张压平均值(58.89±18.88)略高于对照组(54.85±19.28)(P=0.317)。舒张压差异大于收缩压差异。然而，这些检测到的差异是轻微的，没有统计学意义。结论:本研究显示，在服用头孢曲松至少48小时的3岁以上儿童中，血压水平与头孢曲松治疗之间没有关联。然而，建议进行更多的研究，重点关注药物在较高剂量和服药后较长时间内的效果。
{"title":"Evaluation of Blood Pressure in Children Treated with Ceftriaxone: A Case-Control Study","authors":"Mahdi Esmaeili, Roham Sarmadian, Gholamali Fatahibayat, Parsa Yousefichaijan, Danial Habibi","doi":"10.35516/jjps.v16i3.1608","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.1608","url":null,"abstract":"Background: In children, high blood pressure can develop into hypertension and its consequences during puberty and adulthood. High blood pressure in children is often secondary to other causes, including renal diseases. Nephrolithiasis is one of the causes of secondary hypertension. The extensive use of cephalosporins in hospitals, particularly ceftriaxone, can result in nephrolithiasis. Therefore, the purpose of this study was to assess the relationship between ceftriaxone treatment and elevated blood pressure in children. Method: The research was conducted as a case-control study over an 18-month period from 2018 to 2019. In this study, blood pressure was measured in 111 children aged 3-13 years who were hospitalized at Amir Kabir Hospital in Arak and received ceftriaxone for at least 48 hours. As a control group, 111 children who did not receive ceftriaxone had their blood pressure measured. The blood pressure levels and percentiles of children in the two groups were then compared. Result: In the case and control groups, the mean age was 5.1±1.61 and 6.04±2.4 years, and the mean height was 109.17±10.71 and 114.86±12.95 cm, respectively. A slightly higher mean systolic blood pressure percentile was observed in the case group (65.59±18.17) than in the control group (65.28±14.51) (P=0.112), and the mean diastolic blood pressure percentile was also slightly higher in the case group (58.89±18.88) than in the control group (54.85±19.28) (P=0.317). The difference in diastolic blood pressure was greater than in systolic blood pressure. However, these detected differences were slight and not statistically significant. Conclusion: This study showed no association between blood pressure levels and ceftriaxone treatment in children older than three years who received the medicine for at least 48 hours. However, additional research is suggested, focusing on the effects of the medicine at higher doses and over a longer period of time following administration.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khalid Abdulrahman Alhrerat, Zainab Zakaraya, Wael Abu Dayyih, Mohammad Hailat, Mohammed Hamad, Ibrahim Alabbadi
This study delves into recent legislation in Jordan regarding the decriminalization of narcotics and traces the evolution of related legislation in the country. It explores the definition and underlying philosophy of decriminalization while examining arguments from both proponents and opponents of drug decriminalization from a jurisprudential perspective. Additionally, the research sheds light on practices that have emerged in response to the decriminalization of narcotics in other jurisdictions. The study thoroughly examines the advantages and disadvantages of decriminalizing narcotics, analyzing its potential impact on drug consumption. Finally, the researcher proposes the implementation of a gradual and partial systematic plan within Jordanian legislation to address the growing trend of drug decriminalization. The paper also provides insights into the stances of the United States and other countries on this issue and how their legislations have addressed it.
{"title":"Decriminalization of Narcotics in Jordanian Legislation: Theory and Practice","authors":"Khalid Abdulrahman Alhrerat, Zainab Zakaraya, Wael Abu Dayyih, Mohammad Hailat, Mohammed Hamad, Ibrahim Alabbadi","doi":"10.35516/jjps.v16i3.722","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.722","url":null,"abstract":"This study delves into recent legislation in Jordan regarding the decriminalization of narcotics and traces the evolution of related legislation in the country. It explores the definition and underlying philosophy of decriminalization while examining arguments from both proponents and opponents of drug decriminalization from a jurisprudential perspective. Additionally, the research sheds light on practices that have emerged in response to the decriminalization of narcotics in other jurisdictions. The study thoroughly examines the advantages and disadvantages of decriminalizing narcotics, analyzing its potential impact on drug consumption. Finally, the researcher proposes the implementation of a gradual and partial systematic plan within Jordanian legislation to address the growing trend of drug decriminalization. The paper also provides insights into the stances of the United States and other countries on this issue and how their legislations have addressed it.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burns refer to damage to the skin's surface caused by exposure to high temperatures, which can be due to factors such as oil, water, electricity, fire, sun exposure, and chemicals. Prompt and appropriate treatment is essential to prevent undesirable consequences. Thus, this study aimed to quantify mangiferin, a potential treatment for burns, in the bioactive fraction of mango leaves (Mangifera indica L.) and evaluate its effectiveness in healing burns.The methods employed included thin-layer chromatography (TLC)-densitometry with validation measures, including linearity, detection and quantification limits (LoD and LoQ), precision, accuracy, and quantification. The bioactive fraction was formulated in membranes at concentrations of 5%, 10%, and 15%. These membranes were applied to rabbits previously subjected to six wound burns, and the healing progress was monitored by measuring burn diameter using a vernier caliper every 3 days for a total of 21 days. Mangiferin, the active compound, was detected at a wavelength of 257 nm. Test results yielded a linearity equation, y = 76496x + 2935.7, with a correlation coefficient value of 0.9957, a detection limit of 2.01 µg/mL, a quantification limit of 6.07 µg/mL, a coefficient of variation ranging from 0.59% to 3.33%, and an accuracy range of 99.18% to 100.9%, with mangiferin levels at 208.31 µg/mL. The membrane preparations of the bioactive mangiferin fraction were evaluated on second-degree burns in rabbits, with concentrations of 10% and 15% showing the most effectiveness.
{"title":"Quantification of Mangiferin from the Bioactive Fraction of Mango Leaves (Mangifera indica L.) and Evaluation of Wound-Healing Potential","authors":"Valdy Filando Sardi, Astika Astika, Ilza Milenia Jalius, Friardi Ismed","doi":"10.35516/jjps.v16i3.652","DOIUrl":"https://doi.org/10.35516/jjps.v16i3.652","url":null,"abstract":"Burns refer to damage to the skin's surface caused by exposure to high temperatures, which can be due to factors such as oil, water, electricity, fire, sun exposure, and chemicals. Prompt and appropriate treatment is essential to prevent undesirable consequences. Thus, this study aimed to quantify mangiferin, a potential treatment for burns, in the bioactive fraction of mango leaves (Mangifera indica L.) and evaluate its effectiveness in healing burns.The methods employed included thin-layer chromatography (TLC)-densitometry with validation measures, including linearity, detection and quantification limits (LoD and LoQ), precision, accuracy, and quantification. The bioactive fraction was formulated in membranes at concentrations of 5%, 10%, and 15%. These membranes were applied to rabbits previously subjected to six wound burns, and the healing progress was monitored by measuring burn diameter using a vernier caliper every 3 days for a total of 21 days. Mangiferin, the active compound, was detected at a wavelength of 257 nm. Test results yielded a linearity equation, y = 76496x + 2935.7, with a correlation coefficient value of 0.9957, a detection limit of 2.01 µg/mL, a quantification limit of 6.07 µg/mL, a coefficient of variation ranging from 0.59% to 3.33%, and an accuracy range of 99.18% to 100.9%, with mangiferin levels at 208.31 µg/mL. The membrane preparations of the bioactive mangiferin fraction were evaluated on second-degree burns in rabbits, with concentrations of 10% and 15% showing the most effectiveness.","PeriodicalId":14719,"journal":{"name":"Jordan Journal of Pharmaceutical Sciences","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135965496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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