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Spontaneous aneurysm of a common digital artery: a rare entity. 指总动脉自发性动脉瘤:罕见病例。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-02-14 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202400832
Thilina Gunawardena

Aneurysms of arteries of the hand are rarely encountered. Literature reports such aneurysms in the distal ulnar artery, the palmar artery, and the digital arteries. Most are false aneurysms involving trauma-induced defects of the vessel wall. True aneurysms with intact intimal, medial, and adventitial layers of the arterial wall are more unusual. In this case report, we present a 77-year-old previously healthy lady who was diagnosed with a true aneurysm of a common digital artery when she presented with a pulsatile lump over her left palm.

手部动脉动脉瘤是罕见的。文献报道这类动脉瘤位于尺动脉远端、掌动脉和指动脉。大多数是假性动脉瘤,涉及外伤引起的血管壁缺陷。具有完整动脉壁内膜、内侧和外膜的真动脉瘤更为罕见。在本病例报告中,我们报告了一位77岁的健康女性,当她在左手掌出现搏动性肿块时,被诊断为真指总动脉动脉瘤。
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引用次数: 0
Accuracy of duplex ultrasound in peripheral artery disease: a systematic review and meta-analysis. 超声诊断外周动脉疾病的准确性:一项系统综述和荟萃分析。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-02-14 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202400332
Silfayner Victor Mathias Dias, Ronald Luiz Gomes Flumignan, Nelson Carvas, Wagner Iared

Lower limb peripheral artery disease (PAD) is highly prevalent. Current guidelines recommend duplex ultrasound (DUS) with spectral analysis for diagnosis. This systematic review and meta-analysis assessed the diagnostic accuracy of DUS in symptomatic PAD patients. We searched electronic databases for studies comparing DUS and arteriography. Arteries were analyzed individually and grouped into segments (aorto-common femoral, femoropopliteal, below the knee, and the entire lower limb). The meta-analysis estimated sensitivity, specificity, likelihood, and diagnostic odds ratios (DOR). Fifteen studies were included, analyzing 9,067 arteries. DUS accuracy for symptomatic PAD was 0.86 (95% CI 0.81-0.90) for sensitivity and 0.95 (95% CI 0.78-0.97) for specificity. The best results were observed for the femoropopliteal segment: sensitivity 0.86 (95% CI 0.80-0.90), specificity 0.95 (95% CI 0.93-0.97). The poorest performance was observed for the below-the-knee segment: sensitivity 0.78 (95% CI 0.60-0.89), specificity 0.92 (95% CI 0.78-0.97). Most studies had high and unclear risk of bias. There is significant heterogeneity in results, with a limited number of primary studies for each arterial segment, especially for the below-the-knee segment.

下肢外周动脉疾病(PAD)非常普遍。目前的指南推荐双超声(DUS)与光谱分析诊断。本系统综述和荟萃分析评估了DUS在有症状的PAD患者中的诊断准确性。我们检索了电子数据库中比较DUS和动脉造影的研究。单独分析动脉,并将其分组(主动脉-股总动脉、股腘动脉、膝下动脉和整个下肢动脉)。该荟萃分析估计了敏感性、特异性、可能性和诊断优势比(DOR)。纳入了15项研究,分析了9067条动脉。症状性PAD的DUS敏感性为0.86 (95% CI 0.81-0.90),特异性为0.95 (95% CI 0.78-0.97)。在股腘段观察到最好的结果:敏感性0.86 (95% CI 0.80-0.90),特异性0.95 (95% CI 0.93-0.97)。膝关节以下部位表现最差:敏感性0.78 (95% CI 0.60-0.89),特异性0.92 (95% CI 0.78-0.97)。大多数研究的偏倚风险高且不明确。结果存在显著的异质性,对每个动脉段的初步研究数量有限,尤其是对膝盖以下的动脉段。
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引用次数: 0
Portal-splenic-mesenteric venous thrombosis in COVID-19 patients: a systematic review. COVID-19患者门静脉-脾-肠系膜静脉血栓形成:系统综述。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202301282
Ricardo Zanetti Gomes, Matheus Von Jelita Salina, Vitor Hugo Moro Pironatto, Julia Kapp Lepinski, Tiago Daniel Gueiber, Beatriz Moreira Salles Juliatto, Milena Zadra Prestes, Camila Marinelli Martins

The COVID-19 pandemic affected millions of people worldwide. In addition to respiratory impairment, this viral infection can also provoke gastrointestinal symptoms caused by vascular disorders, such as portal-splenic-mesenteric venous thrombosis (PSMVT). This systematic review aimed to investigate the profile of patients who developed PSMVT concomitant with or after viral infection and its predominant outcomes. The database searches returned 214 articles. Of these, 40 case reports were included in the review, presenting a total of 41 cases of PSMVT addressed. Males were more prevalent (n=27; 65.85%), mean age was 51.54 years, and 19.57% had a previous history of endocrine diseases. Statistically significant relationships (p<0.05) were found between patient death and tachypnea at hospital admission (p=0.043) and between patient death and age (p=0.019). It was therefore possible to identify the main profiles and risk factors for PSMVT development and mortality of COVID-19 infected patients.

2019冠状病毒病大流行影响了全球数百万人。除了呼吸障碍外,这种病毒感染还可引起由血管疾病引起的胃肠道症状,如门静脉-脾静脉-肠系膜静脉血栓形成(PSMVT)。本系统综述旨在调查伴随病毒感染或病毒感染后发生PSMVT的患者及其主要结局。数据库搜索返回214篇文章。其中,40例病例报告被纳入审查,总共涉及41例PSMVT。男性更普遍(n=27;65.85%),平均年龄51.54岁,19.57%有内分泌疾病史。统计上显著的关系(p
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引用次数: 0
Brazilian Consensus Statement on Lipedema using the Delphi methodology. 使用德尔菲方法的巴西脂水肿共识声明。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202301832
Alexandre Campos Moraes Amato, Ana Paula Rolim Maia Peclat, Rodrigo Kikuchi, Antonio Carlos de Souza, Mariana Thalyta Bertolin Silva, Roney Hans Prager de Oliveira, Daniel Augusto Benitti, Julio Cesar Peclat de Oliveira

Lipedema, historically underrecognized, has recently gained attention due to advancements in research and growing public awareness. The Brazilian Consensus Statement on Lipedema, developed by the Brazilian Society of Angiology and Vascular Surgery, aims to establish clear recommendations for the diagnosis, treatment, and management of lipedema. Using the Delphi methodology, experts elaborated 90 statements about lipedema, which were then evaluated by a panel of 113 professionals. The statements were analyzed using SurveyMonkey, with a 75% agreement threshold required for their inclusion in the consensus statement. Most statements achieved significant consensus, with only 9 topics requiring further investigation. This consensus statement highlights the complexity of lipedema, the effectiveness of conservative treatment over surgery, the need for multidisciplinary approaches, and the importance of awareness to reduce underdiagnosis and stigma. It also underscores the ongoing need for research to develop more effective management strategies.

由于研究的进步和公众意识的提高,历来未被充分认识的脂肪水肿最近得到了关注。由巴西血管学和血管外科学会制定的巴西脂水肿共识声明旨在为脂水肿的诊断、治疗和管理建立明确的建议。使用德尔菲方法,专家们详细阐述了90个关于脂肪水肿的陈述,然后由113名专业人员组成的小组进行评估。这些陈述是使用SurveyMonkey进行分析的,75%的同意阈值要求将其纳入共识陈述。大多数声明达成了重要的共识,只有9个主题需要进一步调查。这一共识声明强调了脂肪水肿的复杂性、保守治疗优于手术治疗的有效性、多学科方法的必要性以及减少诊断不足和污名的重要性。它还强调目前需要进行研究,以制定更有效的管理战略。
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引用次数: 0
Andexanet alfa for oral fxa inhibitor-associated major acute intracerebral hemorrhage: insights into clinically relevant thromboembolic events from the ANNEXA-I study. anddexanet alfa用于口服fxa抑制剂相关的严重急性脑出血:来自ANNEXA-I研究的临床相关血栓栓塞事件的见解
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-01-20 eCollection Date: 2024-01-01 DOI: 10.1590/1677-5449.202401332
Mateo Porres-Aguilar, Luis Antonio Meillon-Garcia, João Carlos de Campos Guerra
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引用次数: 0
Lipedema: exploring pathophysiology and treatment strategies - state of the art. 脂水肿:探索病理生理学和治疗策略-艺术状态。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-01-20 eCollection Date: 2024-01-01 DOI: 10.1590/1677-5449.202400252
Fabio Kamamoto, Jaqueline Munaretto Timm Baiocchi, Bernardo Nogueira Batista, Renan Diego Américo Ribeiro, Débora Aparecida Oliveira Modena, Vitor Cervantes Gornati

Lipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.

脂肪水肿的特征是异常脂肪沉积在手臂、臀部、臀部和大腿等部位,手和脚除外。症状包括疼痛、瘀伤、水肿和皮下结节,这些症状抵抗传统的干预措施,如饮食和运动。尽管越来越多的认识,全面的了解,包括病理生理,临床和治疗方面,还没有完全实现。这篇综述旨在填补这一领域的知识空白,以支持更明智的管理脂水肿。这篇叙述性综述提供了对脂肪水肿治疗的更深层次的理解,解决了病理生理学和治疗选择。这些数据揭示了知识的进步,特别是在保守和手术治疗方面,重点是提高生活质量。然而,缺乏支持各种治疗方法的安全性和有效性的科学证据。需要进一步的研究来确保安全性并提高对这种复杂疾病的治疗效果。
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引用次数: 0
Techniques for randomization and allocation for clinical trials. 临床试验的随机化和分配技术。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-01-13 eCollection Date: 2024-01-01 DOI: 10.1590/1677-5449.202400462
Anna Carolina Miola, Ana Cláudia Cavalcante Espósito, Hélio Amante Miot

Intervention studies require all participants to originate from the same population, with random allocation to intervention groups to ensure comparability. Randomization is crucial for minimizing confounding factors, allowing differences in outcomes to be attributed to the intervention. Simple randomization performs well for large samples (>100 per group), but smaller samples may require block or stratified randomization to balance group sizes and covariates. When randomization isn't feasible, quasi-randomized methods (e.g., based on dates or enrollment order) can help but must compensate with multivariate adjustments. Moreover, blinding and allocation concealment enhance internal validity and reproducibility. Allocation concealment (e.g., sealed envelopes) prevents bias during participant assignment while blinding mitigates detection and performance biases. Precise methodological descriptions in clinical trial registrations and publications enhance study reliability and reproducibility, highlighting the importance of rigorous planning and transparent reporting in intervention research. This article reviews the key concepts of randomization, blinding, and allocation concealment in interventional studies.

干预研究要求所有参与者来自同一人群,随机分配到干预组以确保可比性。随机化对于最大限度地减少混杂因素至关重要,允许将结果的差异归因于干预措施。简单随机化对于大样本(每组100个)表现良好,但较小的样本可能需要块或分层随机化来平衡组大小和协变量。当随机化不可行时,准随机化方法(例如,基于日期或入学顺序)可以有所帮助,但必须通过多变量调整进行补偿。此外,盲法和分配隐藏提高了内部效度和可重复性。分配隐藏(例如,密封的信封)可以防止参与者分配过程中的偏差,而盲法可以减轻检测和表现偏差。临床试验注册和出版物中精确的方法描述提高了研究的可靠性和可重复性,突出了干预研究中严格计划和透明报告的重要性。本文综述了干预性研究中随机化、盲法和分配隐藏的关键概念。
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引用次数: 0
Idiopathic pulmonary arteriovenous malformation: a rarity in clinical practice. 特发性肺动静脉畸形:罕见的临床实践。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-01-13 eCollection Date: 2024-01-01 DOI: 10.1590/1677-5449.202400052
Tarcila Gurgel Aquino, Diogenes de Melo Jacó, Ingryd Gabriella Nascimento Santos, Eliauria Rosa Martins

Pulmonary arteriovenous malformations (PAVM) are characterized by abnormal pulmonary vessels forming arteriovenous shunts that compromise oxygenation of the blood, causing hypoxemia, and predispose to infections and cerebral ischemia. The patient in this case was a 38-year-old male who presented with tachypnea and dyspnea, cyanosis of extremities, and significant digital clubbing. The patient had structural epilepsy secondary to neurosurgery for a cerebral abscess during childhood. Arterial blood gas analysis showed significant hypoxemia (PaO2 = 46.2; SaO2 = 77%; PaO2/FiO2 = 70) and a chest computed tomography showed PAVM in the apical segments of the right upper and lower lobes, with ectatic and tortuous vascular structures following an intraparenchymal path, communicating with the pulmonary artery and veins. After confirmation of the PAVM, it was concluded that elevated pulmonary resistance was contributing to refractive hypoxemia and hypercapnia. Gradual reduction of the ventilation parameters, primarily controlled pressure and positive end-expiratory pressure, and consequent reduction of the arteriovenous shunt, resulted in progressive improvement of oxygenation and respiratory mechanics. The vascular surgery team's assessment was that treatment with embolization was warranted.

肺动静脉畸形(PAVM)的特征是异常的肺血管形成动静脉分流,损害血液的氧合,引起低氧血症,易发生感染和脑缺血。该病例患者为一名38岁男性,表现为呼吸急促和呼吸困难,四肢发绀,以及明显的指棒。患者在儿童时期因脑脓肿进行神经外科手术后继发结构性癫痫。动脉血气分析显示明显低氧血症(PaO2 = 46.2;SaO2 = 77%;PaO2/FiO2 = 70),胸部ct示右上、下叶顶端段PAVM,伴肺实质内通道扩张、弯曲血管结构,与肺动脉、静脉相通。在确认PAVM后,结论是肺阻力升高导致屈光性低氧血症和高碳酸血症。逐渐降低通气参数,主要控制压力和呼气末正压,随之减少动静脉分流,导致氧合和呼吸力学的逐步改善。血管外科小组的评估是栓塞治疗是必要的。
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引用次数: 0
Transposition of the gastroduodenal artery for vascular reconstruction of invasive lesion of the hepatic hilum due to colorectal adenocarcinoma metastasis: case report. 胃十二指肠动脉转位重建结直肠腺癌转移致肝门浸润性病变1例。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-01-13 eCollection Date: 2024-01-01 DOI: 10.1590/1677-5449.202400122
Lucas Lourenço de Oliveira, Iasmin Maria Rodrigues Saldanha, Yago Eloy Souza Barbosa, Renato Mazon Lima Verde Leal, Abner Moreira Sampaio, Annya Costa Araújo de Macedo Goes, Marcelo Leite Vieira Costa

Colorectal cancer is one of the most prevalent malignant neoplasms in Brazil. Hepatectomy for resection of liver metastases plays an essential role in increasing disease-free survival, with the possibility of cure. The feasibility of liver resection depends on factors related to the remaining liver after surgery. In this article, a case is reported on the hepatic metastasectomy approach in a 47-year-old female patient, with colon adenocarcinoma who underwent vascular reconstruction in the same surgical procedure. The intrahepatic mass was transposition of the gastroduodenal artery through the anastomosis of the gastroduodenal artery and the right hepatic artery in a continuous suture, without complications. It is concluded that vascular anastomosis in hepatectomies for colon adenocarcinoma metastases is a complex procedure that requires skill and experience from the surgeon. The success rate is high, but it is important to be aware of the risk factors for complications. The most current data suggest that vascular reconstruction does not alter overall disease-free survival, but further studies are needed.

结直肠癌是巴西最常见的恶性肿瘤之一。肝切除术切除肝转移瘤在提高无病生存率和治愈可能性方面起着至关重要的作用。肝切除的可行性取决于术后剩余肝的相关因素。在这篇文章中,我们报告了一例47岁的女性结肠癌患者,在相同的手术过程中接受了血管重建。肝内肿物经胃十二指肠动脉与肝右动脉吻合连续缝合,胃十二指肠动脉转位,无并发症。结论:结肠腺癌转移肝切除术血管吻合是一项复杂的手术,需要外科医生的技巧和经验。成功率很高,但重要的是要意识到并发症的危险因素。目前的数据显示,血管重建不会改变总体无病生存率,但需要进一步的研究。
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引用次数: 0
Aneurysm of the arch of the great saphenous vein: therapeutic challenge and review of the literature. 大隐静脉弓动脉瘤:治疗挑战及文献回顾。
IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-01-10 eCollection Date: 2024-01-01 DOI: 10.1590/1677-5449.202401072
Badr El Kassimi, Abdelkarim Kharroubi

Venous aneurysms are uncommon and can involve the entire venous system and occur at any age. The presence of these aneurysmal formations at the level of the saphenous vein junction is rarely reported, given the small number of cases described in the literature. We report the case of a 41-year-old patient with an aneurysm in the saphenofemoral junction of the right great saphenous vein, discovered incidentally during a consultation for varicose veins of the right lower limb.

静脉动脉瘤不常见,可累及整个静脉系统,发生于任何年龄。鉴于文献中所描述的病例很少,在隐静脉连接处出现这些动脉瘤形成的报道很少。我们报告的情况下,41岁的病人与动脉瘤在隐股交界处的右大隐静脉,偶然发现在会诊静脉曲张的右下肢。
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引用次数: 0
期刊
Jornal Vascular Brasileiro
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