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A brief review of fluconazole as an antifungal agent and the need for research into its nanoformulation 氟康唑作为抗真菌药物的研究进展及其纳米制剂的研究需要
Q3 Engineering Pub Date : 2022-10-01 DOI: 10.5604/01.3001.0016.2158
S. Nagaraj
Antifungals compounds have gained significant attention, and in this context, fluconazole as an antifungal is used predominantly, and the use of a nanoformulated form of this is discussed.Fluconazole, an FDA-approved antibiotic, is an effective antimicrobial especially used to treat fungal infections. Its uniqueness lies in the fact that it contains fluoride with triazole functionality. Its efficacy against various types of fungus is demonstrated.Although it is one of the effective antibiotics, its side effects are well documented, and due to this, many techniques are tried to improve its efficacy with lesser side effects.In this respect, nanoparticles play a crucial role, and many studies worldwide are carried out on this aspect. Among many nano techniques use of chitosan as well as lipid carriers of fluconazole are being considered. However, systematic studies are warranted to take this aspect into clinical trials.Nano-based platforms seem to be an alternating hope to combat resistance and side effect.A thorough study is the need of the hour to devise a proper nano-based strategy of fluconazole.
抗真菌化合物得到了极大的关注,在这种情况下,氟康唑作为抗真菌药物被主要使用,并讨论了其纳米配方形式的使用。氟康唑是一种经fda批准的抗生素,是一种有效的抗微生物药物,特别用于治疗真菌感染。它的独特之处在于它含有具有三唑功能的氟化物。证明了其对多种真菌的抑制作用。虽然它是一种有效的抗生素,但它的副作用是有据可查的,因此,人们尝试了许多技术来提高它的疗效,减少副作用。在这方面,纳米颗粒起着至关重要的作用,世界范围内开展了许多这方面的研究。在许多纳米技术中,人们正在考虑使用壳聚糖和氟康唑的脂质载体。然而,系统的研究是必要的,将这方面纳入临床试验。纳米平台似乎是对抗耐药性和副作用的交替希望。一个彻底的研究是需要一个小时来设计一个适当的纳米氟康唑的策略。
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引用次数: 0
Development of foam-breaking measures after removing liquid contamination from wells and flowlines by using surface-active substances 利用表面活性物质去除井和管线中的液体污染后的破泡沫措施的发展
Q3 Engineering Pub Date : 2022-10-01 DOI: 10.5604/01.3001.0016.2157
V. Volovetskyi, Ya. Doroshenko, S. Stetsiuk, S. Matkivskyi, O. Shchyrba, Y. Femiak, G. Kogut
The purpose is to consider the complications that arise during the operation of gas condensate wells, in particular, the accumulation of liquid contamination. Development of new approaches to improve the efficiency of the separation equipment performance of gas gathering and treatment systems when a multiphase flow enters. Development of a foam breaking method in a gas-liquid flow after removal of liquid contaminants from wells and flowlines using surfactants.An analysis was made of the complications that may arise when removing liquid contaminants from wells and flowlines using surfactants. Measures have been developed that will make it possible to timely prevent the ingress of foam into the separation equipment of gas gathering and treatment systems. Using computational fluid dynamics (CFD) modelling, an effective foam-breaking device was developed by supplying stable hydrocarbon condensate.A method to minimize the negative impact of foam on the operation of separation equipment after fluid removal from wells and gas condensate field flowlines using a surfactant solution was elaborated. A method for its breaking was proposed to prevent the flow of foam into the gas processing unit. This method foresees the application of the technological scheme layout for supplying a stable hydrocarbon condensate to a gas-liquid flow entering the separators of the first of separation, both the main line and the measuring line. CFD modelling was used to study the process of foam breaking by feeding hydrocarbon condensate into it. The influence of the hydrocarbon condensate supplying method on gas-dynamic processes (distribution of pressure, velocity, volumetric particles of phases), and the efficiency of foam breaking was estimated. It was established that the supply of hydrocarbon condensate from one branch pipe to the pipeline through which the foam moved did not ensure its complete breaking. To increase the efficiency of foam breaking, a device with designed four nozzles for supplying hydrocarbon condensate was developed. CFD modelling made it possible to substantiate that in this case, a pressure reduction zone appeared at the place of condensate supply. Because of a sharp change in pressure, a strong improvement in the effect of foam breaking occurred. The understanding of the regularities of foam breaking processes by hydrocarbon condensate was obtained, and the design of a device for the complete foam breaking was developed.The obtained results of laboratory studies have shown that a sharp decrease in the stability of the foam occurs under the condition of an increase in the volume of stable hydrocarbon condensate added to the studied model of mineralized formation water. Based on the results of CFD modeling, a device for breaking foam by stable hydrocarbon condensate has been worked out, the effectiveness of which will be confirmed experimentally and in field conditions.The results of the performed laboratory studies and CFD modelling allow a mo
目的是考虑在凝析气井运行过程中出现的复杂性,特别是液体污染的积累。开发新方法以提高多相流进入时气体收集和处理系统的分离设备性能的效率。在使用表面活性剂去除井和管线中的液体污染物后,开发气液流动中的破泡方法。分析了使用表面活性剂去除井和管线中的液体污染物时可能出现的并发症。已经制定了措施,将有可能及时防止泡沫进入气体收集和处理系统的分离设备。利用计算流体力学(CFD)模型,通过提供稳定的凝析油,研制了一种有效的破泡装置。阐述了一种利用表面活性剂溶液,最大限度地减少泡沫对油井脱液后分离设备运行和凝析气田管线运行的负面影响的方法。提出了一种防止泡沫流入气体处理装置的破壁方法。该方法预测了向进入第一段分离装置的气液流(包括主线和测量线)分离器的气液流提供稳定的烃类凝析液的工艺方案布置的应用。采用CFD模型研究了油气凝析液注入破泡过程。分析了凝析油供给方式对气相动力学过程(压力分布、速度分布、相体积颗粒分布)和破泡效率的影响。结果表明,从一个分支管道向泡沫移动的管道输送凝析油并不能保证泡沫的完全破裂。为了提高破泡效率,设计了一种四喷嘴供凝析油装置。CFD模型可以证实,在这种情况下,冷凝水供应处出现了一个减压区。由于压力的急剧变化,泡沫破裂的效果有了很大的改善。了解了凝析油破泡过程的规律,设计了一种完全破泡装置。实验室研究结果表明,在矿化地层水模型中加入稳定的凝析油体积增加的情况下,泡沫的稳定性急剧下降。在CFD模拟结果的基础上,设计了稳定凝析油破泡装置,并将在实验和现场条件下验证其有效性。进行的实验室研究和CFD建模的结果允许使用更合理的方法和措施,以防止泡沫随着气液流进入气体收集和处理系统的分离设备。这种方法使开发新的有效方法和措施来预防这种并发症成为可能。基于CFD模型,发现当稳定的油气凝析液进入气液流动时,泡沫破裂。本文提出了一种在气液流动中破泡的方法,该方法具有独创性,可应用于实际。
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引用次数: 1
Effect of particle size on surface roughness and morphology of heat-treated electroless Ni-YSZ coating 粒度对Ni-YSZ化学涂层表面粗糙度和形貌的影响
Q3 Engineering Pub Date : 2022-09-01 DOI: 10.5604/01.3001.0016.1477
N. Bahiyah Baba, A. S. Ghazali, S. N. Azinee, A. A. Abdul Rahman, S. Sharif
The paper discusses the surface characterisation of electroless nickel-yttria-stabilised zirconia (Ni-YSZ) coating with varying YSZ particle sizes and undergoes heat treatment at a temperature between 300-400°C for 1-2 hours for wear resistance purposes. This finding will be helpful to the application of Ni-YSZ as an alternative coating for cutting tools.The surface characterisation was analysed using JOEL Scanning Electron Microscope (SEM) coupled with Energy Dispersive X-ray (EDX) JSM 7800F. The crystallographic structure of materials was analysed by X-ray diffraction (XRD) Bruker D8 Advance instrument. The Ni-YSZ coating was deposited using electroless nickel co-deposition of 8YSZ ceramic particles with a nano, mixed and microparticle sizes onto a high-speed steel (HSS) substrate. The coatings were heat treated at temperature 300-400°C and time 1-2 hours. The surface roughness was measured using Mitutoyo surface roughness tester SJ-301.The electroless Ni-YSZ coating deposited has an average thickness of 30 µm. It is found that the coating morphology electroless coating without YSZ particle incorporation (EN) and Ni-YSZ nano (N) is smoother compared to the Ni-YSZ mixed (NM) and Ni-YSZ micro (M). The EDS composition analysis shows the YSZ content in the electroless Ni-YSZ coating for N samples is the lowest, whereas NM samples are the highest. This resulted in the surface roughness behaviour where the mixed-size YSZ particle gives the highest roughness at all temperatures. The XRD analysis shows that heating temperatures above 300°C caused the precipitation of Ni3P crystalline.Previous studies in the surface characterisation of electroless nickel composite are scarce; thus, the study has limitations in finding supporting data.The surface characterisation especially related to the surface roughness of the electroless nickel, either the Ni-P or composites or alloys are rarely reported. Thus, this study enlightened the effect of particle size on surface roughness and morphology of heat-treated coatings.
本文讨论了不同YSZ粒度的化学镍钇稳定氧化锆(Ni-YSZ)涂层的表面特征,并在300-400℃的温度下进行1-2小时的热处理以达到耐磨目的。这一发现将有助于Ni-YSZ作为切削刀具的替代涂层的应用。利用JOEL扫描电镜(SEM)和能量色散x射线(EDX) JSM 7800F对其进行了表面表征。采用Bruker D8 Advance型x射线衍射仪(XRD)分析了材料的晶体结构。采用化学镍共沉积方法,在高速钢基体上制备了纳米级、混合级和微米级8YSZ陶瓷颗粒的Ni-YSZ涂层。涂层在温度300-400℃,时间1-2小时下进行热处理。表面粗糙度采用Mitutoyo表面粗糙度测试仪SJ-301进行测量。化学沉积的Ni-YSZ涂层平均厚度为30µm。结果表明,与Ni-YSZ混合镀层(NM)和Ni-YSZ微镀层(M)相比,未掺入YSZ颗粒的化学镀层(EN)和Ni-YSZ纳米镀层(N)的镀层形貌更为光滑。EDS成分分析表明,N镀层中YSZ含量最低,NM镀层中YSZ含量最高。这导致了表面粗糙度行为,其中混合尺寸的YSZ颗粒在所有温度下都具有最高的粗糙度。XRD分析表明,300℃以上的加热温度导致Ni3P结晶析出。以往对化学镀镍复合材料表面表征的研究很少;因此,本研究在寻找支持数据方面存在局限性。化学镀镍,无论是Ni-P还是复合材料或合金的表面粗糙度的表面表征很少被报道。因此,该研究揭示了颗粒尺寸对热处理涂层表面粗糙度和形貌的影响。
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引用次数: 0
Cancer therapeutics strategy using nano-carrier mediated natural drugs 利用纳米载体介导的天然药物治疗癌症的策略
Q3 Engineering Pub Date : 2022-09-01 DOI: 10.5604/01.3001.0016.1481
S. Shaw, P. Singh, R. Mishra, R. Singh, R. Nayak, S. Bose
Nucleolin is a multifactorial protein, having a significant role in chromatin remodelling, mRNA stability, ribosome biogenesis, stemness, angiogenesis, etc., thus, it is potential therapeutic target in cancer. The purpose of this paper is to study porous silicon (pSi) nanocarrier-based natural drug delivery system targeting dysregulated nucleolin expression for cancer therapeutics.Quercetin was loaded in pre-synthesized and characterized pSi nanoparticles, and release kinetics was studied. The study compared the inhibitory concentration (IC50) of quercetin, synthetic drug doxorubicin, and quercetin-loaded pSi nanoparticles. Further, mRNA expression of a target gene, nucleolin, was tested with a quercetin treated breast cancer cell line (MCF-7).Quercetin-loaded pSi nanoparticles followed first-order release kinetics. IC50 was determined at concentrations of 312 nM, 160 µM, and 50 µM against doxorubicin, quercetin, and quercetin-loaded pSi nanoparticles, respectively. The results further indicated 16-fold downregulation of nucleolin mRNA expression after 48h of quercetin treatment of exponentially growing MCF-7 cells.Whether pSi nanoparticle loaded quercetin can significantly downregulate nucleolin protein expression and its impact on apoptosis, cell proliferation, and angiogenic pathways need further investigation.The practical application of the proposed nanocarrier-based drug delivery system potentially lays out a path for developing targeted therapy against nucleolin-dysregulated cancer using natural products to minimize the side effects of conventional chemotherapeutic drugs.Inhibition of nucleolin and nucleolin regulated pathways using natural compounds and its targeted delivery with nanocarrier is not yet done.
核蛋白是一种多因子蛋白,在染色质重塑、mRNA稳定性、核糖体生物发生、干性、血管生成等方面具有重要作用,是治疗癌症的潜在靶点。本文的目的是研究基于多孔硅(pSi)纳米载体的靶向核蛋白表达失调的天然药物递送系统在癌症治疗中的应用。将槲皮素装入预合成的pSi纳米颗粒中,并对其进行表征,研究其释放动力学。本研究比较了槲皮素、合成药物阿霉素和负载槲皮素的pSi纳米颗粒的抑制浓度(IC50)。此外,用槲皮素处理的乳腺癌细胞系(MCF-7)检测靶基因核仁蛋白的mRNA表达。负载槲皮素的pSi纳米颗粒具有一级释放动力学。分别在浓度为312 nM、160µM和50µM的条件下对阿霉素、槲皮素和负载槲皮素的pSi纳米颗粒进行IC50测定。结果进一步表明,槲皮素作用于指数生长的MCF-7细胞48h后,核仁蛋白mRNA表达下调16倍。pSi纳米颗粒负载槲皮素是否能显著下调核仁蛋白的表达及其对细胞凋亡、细胞增殖和血管生成通路的影响有待进一步研究。所提出的基于纳米载体的药物递送系统的实际应用可能为利用天然产物开发针对核蛋白失调癌症的靶向治疗开辟了一条道路,以最大限度地减少传统化疗药物的副作用。利用天然化合物抑制核仁蛋白和核仁蛋白调控途径及其纳米载体的靶向递送尚未完成。
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引用次数: 0
Probability-statistical estimation method of feed influence on the tangential cutting force under turning 车削时进给对切向切削力影响的概率统计估计方法
Q3 Engineering Pub Date : 2022-09-01 DOI: 10.5604/01.3001.0016.1480
V. Krúpa, N. Tymoshenko, V. Kobelnyk, I. Petrechko
This research aims to develop the mathematical model and propose a method for estimating the feed stochasticity impact on the tangential cutting force during turning. The main reason for this research is that the existing models for determining the tangential component of the cutting force do not take into account the stochasticity of the feed rate.Measurements of tangential cutting force during turning on general-purpose lathes with known feed dispersion parameters were made. The mathematical model was developed, and dispersion characteristics (mean value, dispersion and mean square deviation) of the tangential cutting force component depending on the corresponding dispersion characteristics of the feed rate were obtained. The method of assessing the impact of stochasticity of the feed rate on the tangential cutting force is proposed.As the result of the carried-out investigations, it is proved that the stochasticity of the feed rate affects the dispersion of the tangential cutting force during turning. For specific conditions, the share of feed stochasticity in the dispersion of tangential cutting force component is from 40 to 60% and should be taken into account while prescribing rational cutting modes.The obtained results make it possible to adjust the cutting modes, particularly the amount of feed, under the conditions of real equipment to ensure certain power characteristics of the cutting process to prevent overloads during cutting. This investigation benefits to the establishment of additional factors affecting oscillations in the cutting process.The probabilistic-statistical approach is used in this investigation in order to prove that the stochasticity of the feed rate affects the dispersion of the tangential cutting force component.
本研究旨在建立车削过程中进给随机性对切向切削力影响的数学模型,并提出一种估计方法。本研究的主要原因是现有的确定切削力切向分量的模型没有考虑进给速度的随机性。对已知进给分散参数的通用车床车削切向切削力进行了测量。建立了数学模型,得到了切向切削力分量随进给速度相应的离散特性的离散特性(平均值、离散度和均方差)。提出了一种评估进给速度随机性对切向切削力影响的方法。研究结果表明,进给速度的随机性会影响车削过程中切向切削力的分散。在特定条件下,进给随机性在切向切削力分量弥散中所占的份额为40% ~ 60%,在制定合理的切削模式时应予以考虑。所得结果使得在实际设备条件下调整切削模式,特别是进给量成为可能,以保证切削过程的一定功率特性,防止切削过程中过载。该研究有助于建立影响切削过程中振荡的附加因素。为了证明进给速度的随机性会影响切向切削力分量的离散性,本文采用了概率统计方法。
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引用次数: 0
Combined carbon content assessment method for powder metallurgy 粉末冶金碳含量综合评定方法
Q3 Engineering Pub Date : 2022-09-01 DOI: 10.5604/01.3001.0016.1479
A. Stanula, W. Pilarczyk
Powder metallurgy (PM) lacks a clear method to analyse the combined carbon content based on metallography visualisation, and this article describes the creation of such a method for powder materials.Different methods are used to analyse combined carbon within metallurgical samples, and the hardness of components within the automotive industry is related to this question.The main aim of this paper is to determine if optical microscopy provides a reliable means to assess the combined carbon content.For checking these items, the Optical Microscope will be used, density, hardness of sinter material, and particle size laser analysis of powder for creating the observed compact, and SEM microscope.This investigation provides standardised rules that can be implemented within any material laboratory.The analysis of powder particle size, hardness test, density check, and the investigation of the structure of powder element are presented.
粉末冶金(PM)缺乏一种基于金相可视化分析组合碳含量的明确方法,本文描述了粉末材料这种方法的创建。不同的方法用于分析冶金样品中的结合碳,汽车工业中部件的硬度与此问题有关。本文的主要目的是确定光学显微镜是否提供了一种可靠的方法来评估组合碳含量。为了检查这些项目,将使用光学显微镜,烧结材料的密度、硬度和粒度,激光分析粉末以创建观察到的致密物,并使用SEM显微镜。这项调查提供了可以在任何材料实验室实施的标准化规则。介绍了粉末粒度分析、硬度测试、密度校核和粉末元件组织研究。
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引用次数: 0
Pulsed laser deposition of ZnO and MoO3 as reflection prohibitors on photovoltaic cell substrate to enhance the efficiency 在光伏电池衬底上脉冲激光沉积ZnO和MoO3作为反射抑制剂以提高效率
Q3 Engineering Pub Date : 2022-08-01 DOI: 10.5604/01.3001.0016.1414
P. Selvan, D. Jebaraj, N. Hynes
With the ever-growing demand for conventional fuels, the improvement in the efficiency of the photovoltaic system is the need of the hour. Antireflection coatings enhance the availability of solar power by reducing the percentage of light reflected. A new coating has been developed to improve the solar cell's overall efficiency. This study focuses on enhancing the efficiency of the monocrystalline solar cell when a coating of ZnO-MoO3 is applied at a certain thickness.A layer of ZnO followed by MoO3 is deposited on a Silicon solar cell substrate using a Pulsed Laser Deposition process. Due to the transmissivity d between the two materials, they act as excellent antireflection coating. The layer thickness has been engineered to lie in the maximum absorption spectrum of monocrystalline silicon solar cells, which is between 400 and 800 nanometers.Based on the calculation of transmissivities for a given layer thickness of coating material, the coating has been done, and the efficiencies of the coated specimen were compared with the uncoated solar cell. The percentage improvement in the electrical efficiency of a single crystalline silicon solar cell with an anti-reflection coating at 1059 W/m2 is about 35.7%.Among the available antireflection coating materials, the combination that provides better efficiency when coated on top of a solar cell is hard to find.This anti-reflection coating could be a better solution to enhance the overall efficiency of the single crystalline silicon solar cell.Although ZnO and MoO3 coatings have been investigated separately for improvement in solar cell efficiency with varying levels of success, the hybrid coating of ZnO/MoO3 with a performance enhancement of 35.7% is a great leap.
随着对常规燃料需求的不断增长,提高光伏发电系统的效率是当务之急。抗反射涂层通过减少光的反射率来提高太阳能的可用性。一种新的涂层已经被开发出来,以提高太阳能电池的整体效率。本研究的重点是在一定厚度的ZnO-MoO3涂层下提高单晶太阳能电池的效率。采用脉冲激光沉积工艺在硅太阳能电池衬底上沉积了一层ZnO和MoO3。由于两种材料之间的透过率d,它们作为优秀的抗反射涂层。该层厚度已被设计为位于单晶硅太阳能电池的最大吸收光谱范围内,即400至800纳米之间。在计算给定涂层厚度下的透射率的基础上,进行了涂层,并将涂层样品与未涂层的太阳能电池的效率进行了比较。单晶硅太阳能电池在1059 W/m2下的电效率提高了约35.7%。在现有的抗反射涂层材料中,很难找到在太阳能电池顶部涂层的组合,从而提供更好的效率。这种抗反射涂层可能是提高单晶硅太阳能电池整体效率的更好解决方案。虽然ZnO和MoO3涂层分别研究了提高太阳能电池效率的方法,并取得了不同程度的成功,但ZnO/MoO3混合涂层的性能提高了35.7%,是一个巨大的飞跃。
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引用次数: 0
Four-parameter electromagnetic method for determining the parameters of brewery effluents 测定啤酒废水参数的四参数电磁法
Q3 Engineering Pub Date : 2022-08-01 DOI: 10.5604/01.3001.0016.1405
V. Sebko, Y. Pyrozhenko, N. Zashchepkina, V. Zdorenko, O. Markina
of the article is to study a four-parameter electromagnetic method for joint measurements of electrical resistivity k, relative permittivity εr, temperature t and density ρ of samples of acidic, alkaline and average effluents from a microbrewery based on a magnetic flux probe (MFP), which considers the influence of informative parameters of beer effluents on the components of the amplitude and phase signals of a multiparameter device.The implementation of the four-parameter method is carried out on the basis of the dependences G1 = f (A1) and G2 = f (A2) at two frequencies of the electromagnetic field f0 and f1 for acid, alkaline and average effluent and allows you to jointly determine the four parameters of effluent samples with the same converter in the same control area. The proposed method makes it possible to improve the accuracy of identifying effluent samples since the obtained multiparameter information makes it possible to determine the nature and properties of effluent samples using only one transducer with certain physical characteristics. The research results lead to the expansion of the technical capabilities of electromagnetic measurement methods, as well as to an increase in the metrological characteristics of electromagnetic transducers and an increase in the accuracy of measuring the parameters of effluent samples compared to reference methods and measuring instruments. Thus, the implementation of this approach contributes to the prediction and prevention of the reasons for the deviation of beer effluent samples from the specified indicators of environmental safety.The universal conversion functions MFP have been established, connecting the amplitude and phase components of the converter signals with the parameters k, εr, t and ρ of acidic, alkaline and average effluents. Based on the universal transformation functions G1 = f (A1) and G2 = f (A2), a four-parameter electromagnetic method for joint measurements of electrical resistivity k, relative permittivity εr, temperature t and density ρ of acidic, alkaline, and average effluents from breweries has been developed. When conducting research at two close frequencies of the electromagnetic field f0 = 20.3 MHz and f1 = 22 MHz, algorithms were obtained for measuring and calculating procedures for determining k, εr, t and ρ for samples of acidic, alkaline and average effluents from the brewing industry.Research perspectives consist in the creation of automated systems for multiparameter measuring control of the physicochemical characteristics of acidic and alkaline effluent from food and processing industries based on the immersed electromagnetic transducer. Based on the data obtained using informative methods to measure the parameters of effluent samples, an integrated method for treating beer effluents of various compositions will be proposed. At the same time, the scheme of the integrated treatment method should include a filter that provides the introduction of a magnetic f
本文研究了一种基于磁通探头(MFP)的四参数电磁法联合测量某微型啤酒厂酸性、碱性和平均流出液样品的电阻率k、相对介电常数εr、温度t和密度ρ的方法,该方法考虑了啤酒流出液的信息参数对多参数装置的幅相信号分量的影响。四参数法的实现是基于酸性、碱性和平均出水在电磁场f0和f1两个频率下G1 = f (A1)和G2 = f (A2)的依赖关系进行的,可以在同一控制区域内使用同一转换器共同确定出水样品的四个参数。所提出的方法可以提高识别流出液样品的准确性,因为所获得的多参数信息使得仅使用具有某些物理特性的一个换能器就可以确定流出液样品的性质和特性。研究成果拓展了电磁测量方法的技术能力,提高了电磁换能器的计量特性,与参考方法和测量仪器相比,提高了对出水样品参数的测量精度。因此,该方法的实施有助于预测和预防啤酒废水样品偏离环境安全指标的原因。建立了通用转换函数MFP,将变换器信号的振幅和相位分量与酸性、碱性和平均废水的k、εr、t和ρ参数联系起来。基于通用变换函数G1 = f (A1)和G2 = f (A2),提出了一种联合测量酒厂酸性、碱性和平均废水电阻率k、相对介电常数εr、温度t和密度ρ的四参数电磁法。在f0 = 20.3 MHz和f1 = 22 MHz两个相近的电磁场频率下进行研究,得到了测定酿酒工业酸性、碱性和平均废水样品的k、εr、t和ρ的测量和计算程序算法。研究方向包括基于浸入式电磁换能器的食品和加工工业酸性和碱性废水理化特性多参数测量控制自动化系统的创建。基于信息性方法测量出水样品参数所获得的数据,提出了一种综合处理不同成分啤酒出水的方法。同时,综合处理方法的方案应该包括一个过滤器,它提供了磁性流体的引入和一个分离装置,使我们能够去除一部分,包括本身的污染。所提出的四参数电磁方法使确定废水受控样品的成分(酸性或碱性)成为可能。从而可以选择合理的啤酒废水处理方法,防止出水样品偏离标准规定的环境安全指标的原因。本文的研究是通过实施四参数电磁法联合测量酒厂酸性、碱性和平均废水的电阻率k、相对介电常数εr、温度t和密度ρ,来扩展电磁双频换能器MFP的功能和技术能力。在f0 = 20.3 MHz和f1 = 22 MHz两个相近磁场频率下的工作中发现了通用变换函数G1 = f (A1)和G2 = f (A2),使得用相同的MFP可以同时控制酸性、碱性和平均废水的4个理化参数。本文提出了一种确定双频热MFP信号分量的算法,其范围对应于酸性、碱性和普通啤酒废水的电阻率k、相对介电常数εr、温度t和密度ρ的变化范围。得到了双频四参数电磁法联合测量酸性、碱性和平均啤酒废水理化参数的基本关系。
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引用次数: 0
Simulation of the preparation laboratory for light microscopy in the form of a 3D educational game 模拟实验室制备的一款以光学显微镜为形式的三维教育游戏
Q3 Engineering Pub Date : 2022-08-01 DOI: 10.5604/01.3001.0016.1433
R. Honysz
The purpose of the work was to create an educational game to familiarize the user with the methodology of preparing a material sample for light microscopy. The goal of the game is to obtain a correct preparation of the sample, the microstructure of which can be observed under a light microscope.The game was developed in the Unity environment. All three-dimensional machine models, along with the necessary virtual environment and the gameplay scenario, were created.Due to the use of virtual reality, it has become possible to teach students how to use preparation devices without the need for the physical presence of students in the laboratory in an attractive and safe way. Failure to play the game will not damage material, or equipment, there is no risk to the user’s health.The game has been developed and is available in the Department of Engineering Materials and Biomaterials of the Faculty of Mechanical Engineering of the Silesian University of Technology.The form of a 3D game used in this study is an interesting alternative to traditional teaching aids. It can be used not only by students but also teachers and other people who want to broaden their knowledge about the functioning and methods of operation of laboratory equipment.
这项工作的目的是创建一个教育游戏,让用户熟悉为光学显微镜准备材料样品的方法。游戏的目标是获得正确制备的样品,其微观结构可以在光学显微镜下观察到。游戏是在Unity环境下开发的。所有的三维机器模型,以及必要的虚拟环境和游戏场景都被创建出来了。由于虚拟现实的使用,已经可以以一种有吸引力和安全的方式教学生如何使用准备设备,而不需要学生在实验室中亲自出现。失败玩游戏不会损坏材料,或设备,对用户的健康没有风险。该游戏是由西里西亚理工大学机械工程学院工程材料和生物材料系开发并提供的。本研究中使用的3D游戏形式是传统教学辅助工具的有趣替代。它不仅可以被学生使用,也可以被教师和其他想要扩大他们对实验室设备的功能和操作方法的知识的人使用。
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引用次数: 0
Optimisation of variation coolant system techniques in machining aluminium alloy Al319 Al319铝合金加工中变冷系统技术的优化
Q3 Engineering Pub Date : 2022-08-01 DOI: 10.5604/01.3001.0016.1432
S. Z. Zainal Ariffin, A. M. Efendee, A. Redhwan, M. Alias, A. Arifuddin, M. Kamrol Amri, M. M. Mohd Ali, K. Khalil, A. Aminullah, A. Hasnain, N. Baba
Cutting parameters are often chosen for machining by machine operators in the industry. The experience and efficiency of the machine operator in producing a quality product are frequently used to decide parameter selection—low productivity results from improper parameter selection, inefficient machining, and technological issues. Today's key issues in the machining industry are focusing on increasing machining performance on surface roughness while minimising coolant usage. The study's objective is to enhance the performance of the nozzle lubrication system during the turning operation of an aluminium alloy 319 workpieces (Al319) to generate good surface roughness by applying turning parameters such as cutting speed, feed rate, and the depth of cut.Response Surface Method (RSM) was used to create the experimental method for this investigation, carried out using a CNC lathe machine with two axial movements and a wet cooling nozzle with a size of 1.0 mm. Synthetic soluble lubricants, Al2O3-coated cemented carbide inserts, and Aluminium alloy 319 were utilised as cutting tools and workpiece materials.To study the influence of cutting parameters on surface roughness, the Analysis of Variance (ANOVA) approach was utilised while the response surface method was performed to achieve an optimum machining performance (RSM). When comparing dry and wet cooling systems, the size of 1.0 mm nozzle shows appropriate surface roughness. According to the ANOVA analysis, the key factor impacting the surface roughness as machining performance in lubrication technique experiments was the utilisation of 1.0 mm nozzle size.The findings of combination machining parameters at a cutting speed of 270 m/min and a cutting depth of 0.60 mm at a feed rate of 0.08 mm/min offered the best results, achieving a surface roughness, Ra of 0.94 µm.The use of coolant size nozzle 1.0 mm technology combined with the use of correct machining parameters can improve machining cuts.The novel size of 1.0 mm nozzle in this current research is also valuable for reducing and increasing productivity in the machining business, as well as reducing dependency on machining operators' experience and abilities.
在工业中,切削参数通常是由机器操作员选择的。机器操作员在生产高质量产品方面的经验和效率经常被用来决定参数的选择——低生产率是由于参数选择不当、加工效率低下和技术问题造成的。当今机械加工行业的关键问题集中在提高表面粗糙度的加工性能,同时尽量减少冷却剂的使用。该研究的目的是通过应用车削参数(如切削速度、进给速率和切削深度)来提高铝合金319工件(Al319)车削过程中喷嘴润滑系统的性能,以产生良好的表面粗糙度。采用响应面法(RSM)建立了本研究的实验方法,使用两轴向运动的数控车床和尺寸为1.0 mm的湿式冷却喷嘴进行实验。采用合成可溶性润滑剂、al2o3涂层硬质合金刀片和319铝合金作为切削刀具和工件材料。为了研究切削参数对表面粗糙度的影响,采用方差分析(ANOVA)方法,并采用响应面法实现最佳加工性能(RSM)。当比较干式和湿式冷却系统时,1.0 mm喷嘴的尺寸显示出合适的表面粗糙度。方差分析表明,在润滑技术实验中,影响表面粗糙度和加工性能的关键因素是1.0 mm喷嘴尺寸的利用率。结果表明,切削速度为270 m/min,切削深度为0.60 mm,进给速度为0.08 mm/min时的组合加工参数效果最佳,表面粗糙度Ra为0.94µm。采用冷却液尺寸1.0 mm的喷嘴技术,结合使用正确的加工参数,可以提高加工的切削量。在当前的研究中,1.0 mm喷嘴的新尺寸对于降低和提高加工业务的生产率以及减少对加工操作员经验和能力的依赖也很有价值。
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引用次数: 0
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Journal of Achievements in Materials and Manufacturing Engineering
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