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EFFICACY AND PHARMACOECONOMICS STUDY OF SPINAL CORD STIMULATION (SCS) CONDUCTED AT THE PAIN THERAPY HUB, SAN GIULIANO HOSPITAL ASL NAPOLI 2 在那不勒斯圣朱利亚诺医院疼痛治疗中心进行的脊髓刺激(scs)的疗效和药物经济学研究
Pub Date : 2023-09-03 DOI: 10.36017/jahc202353247
Immacolata Filoso, Maria Rosaria Iacolare, Ida Monti, Attilio Tortora, Claudio Contiello, Assunta De Luca, Anna Scarano, Giovanni Gerbi, Gaetano Mignano, Lucio Marcello Falconio
Introduction: Chronic Pain has been recognized by the World Health Organization as one of the major global public health issues. The condition has debilitating consequences from physical, psychological, and socio-relational perspectives due to its highly disabling nature. Spinal Cord Stimulation (SCS) involves the placement of one or more electrodes in the epidural space through surgical means, connected to a fully implantable battery that electrically stimulates the spinal nerve structures. This treatment is indicated for patients suffering from intractable chronic pain in the trunk and limbs, particularly demonstrating efficacy in treating neuropathic pain. This method has been in use since the mid-1970s. The study lasted 24 months, with the initial 8 months involving patient recruitment and the subsequent 16 months devoted to the follow-up period. Its purpose was to evaluate the cost-benefit ratio of SCS in patients with chronic pain, treated at the Pain Therapy Hub of San Giuliano Hospital, ASL Napoli 2 Nord. The primary goal was to assess the effectiveness of Spinal Cord Neurostimulation (SCS) when applied to these patients. By conducting a comparative assessment 16 months after the implantation, the study evaluated the reduction in pain and disability among patients treated with SCS. Additionally, the study analysed the costs incurred by the National Health Service (SSN) and the corresponding benefits achieved in treating patients with chronic pain using SCS. The study is aimed to assess the effectiveness of this treatment in terms of improving patients' health status and quality of life. Materials and Methods: The observational study is retrospective and single cantered, conducted at the regional Pain Therapy Hub of San Giuliano Hospital, ASL Napoli 2 Nord. The study lasted for 24 months, with the initial 8 months dedicated to patient recruitment and the subsequent 16 months for the follow-up period.A total of 39 adult patients capable of managing or tolerating the devices used in SCS were recruited. These patients had a diagnosis of chronic back and/or leg pain and were non-responders to pharmacological therapy and other therapeutic treatments. The patients were provided with information about this study.Sixteen patients were excluded due to psychological or psychiatric disorders, progressive neurological conditions, or being recipients of an intrathecal pump for pain-relief drug infusion or an IPG. The remaining 23 patients received the implantation of a pulse generator and two electrode catheters. This group constituted our cohort, to which questionnaires were administered to evaluate the level of disability using the Oswestry Disability Index (ODI) and pain measurement using the Visual Analog Scale (VAS). Data were collected at Time 0 (T0) and during the subsequent 16 months from the start of treatment (Follow Up). Only 4 out of the 23 patients removed the neurostimulator before the 16-month term due to incompatibility. Quality of life
慢性疼痛已被世界卫生组织确认为主要的全球公共卫生问题之一。由于其高度致残的性质,这种情况会从身体、心理和社会关系的角度造成衰弱的后果。脊髓刺激(SCS)包括通过手术方式在硬膜外空间放置一个或多个电极,连接到一个完全可植入的电池,电刺激脊神经结构。这种治疗方法适用于躯干和四肢难治性慢性疼痛的患者,尤其对神经性疼痛有疗效。这种方法自20世纪70年代中期以来一直在使用。该研究持续了24个月,其中最初的8个月涉及患者招募,随后的16个月用于随访期。其目的是评估SCS在那不勒斯2 Nord圣朱利亚诺医院疼痛治疗中心治疗的慢性疼痛患者的成本效益比。主要目的是评估脊髓神经刺激(SCS)应用于这些患者时的有效性。通过植入后16个月的比较评估,该研究评估了SCS治疗患者疼痛和残疾的减少。此外,该研究还分析了国民健康服务(SSN)的成本以及使用SCS治疗慢性疼痛患者所获得的相应收益。本研究旨在评估该治疗在改善患者健康状况和生活质量方面的有效性。材料和方法:观察性研究是回顾性和单中心的,在那不勒斯2区圣朱利亚诺医院的区域疼痛治疗中心进行。该研究持续了24个月,其中最初的8个月用于招募患者,随后的16个月用于随访。总共招募了39名能够管理或耐受SCS中使用的装置的成年患者。这些患者被诊断为慢性背部和/或腿部疼痛,对药物治疗和其他治疗方法无反应。向患者提供有关本研究的信息。16例患者因心理或精神障碍、进行性神经系统疾病或鞘内泵用于止痛药物输注或IPG而被排除。其余23名患者接受了一个脉冲发生器和两个电极导管的植入。这组患者组成了我们的队列,对他们进行问卷调查,使用Oswestry残疾指数(ODI)评估残疾水平,使用视觉模拟量表(VAS)测量疼痛。数据收集于时间0 (T0)和治疗开始后16个月(随访)。23例患者中只有4例在16个月前因不相容摘除了神经刺激器。通过测量健康如何影响身体、心理和情绪健康(HRQoL)的参数,收集与健康状况相关的生活质量数据。除了ODI之外,还在时间0和随访点管理了额外的信息表,目的是验证ODI的变化是否与HRQoL参数的变化相对应。此外,还对与慢性疼痛患者的治疗有关的由国民保健服务承担的费用所造成的资源消耗数据进行了量化。这些费用分为与住院有关的费用、植入过程中使用的材料和设备,以及执行该程序所使用的仪器和专业资源(直接费用),以及与专家就诊、药物使用、仪器和诊断分析有关的费用(间接费用)。关于时间0的直接费用,考虑了坎帕尼亚每天住院的平均费用,以及SCS植入手术的工具、设备、仪器和药理学资源的平均费用。还考虑了手术中涉及的专业资源的总成本,平均持续时间为2小时(麻醉师、放射技师、手术医师和护士)。最后,考虑了慢性疼痛患者的个人习惯及其护理和管理所产生的非医疗费用。这些费用取决于病人的一般情况。一般来说,这些人的自主权有限,导致专业护理需求的增加和随之而来的成本上升,包括由于缺勤和临时照顾者而导致的生产力下降。所有医疗费用和非医疗费用分别在植入手术前一年和手术后16个月进行评估,后一种评估标准化为12个月,评估期相同。
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引用次数: 0
ci è voluta la mani di dio 这需要上帝的双手
Pub Date : 2023-09-03 DOI: 10.36017/jahc201911244
Rosario Tortora
meno male che ci siamo riusciti
幸好我们成功了
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引用次数: 0
RETROSPECTIVE AND SINGLECENTER STUDY WITH THE AIM OF PHARMAECONOMIC ANALYSIS IN PREGNANCY TERMINATIONS AT SAN GIULIANO HOSPITAL OF ASL NAPOLI 2 NORD. 回顾性和单中心研究,目的是药物经济学分析在那不勒斯北部圣朱利亚诺医院终止妊娠。
Pub Date : 2023-09-03 DOI: 10.36017/jahc202353248
Immacolata Filoso, Maria Rosaria Iacolare, Ida Monti, Attilio Tortora, Claudio Contiello, Assunta De Luca, Anna Scarano, Giovanni Gerbi, Gaetano Mignano, Lucio Marcello Falconio
Introduction: Pregnancy termination (IG) is a widely practiced clinical procedure and can be therapeutic (IGT), pharmacological (IGF), or surgical (IGS). The analysis of total costs associated with different methods is useful to highlight advantages and disadvantages for the patient and to enable decision-makers to intervene in a precise manner on company policies supported by concrete data. The relevant legislation governing pregnancy termination is Law 194/78, with specific reference to voluntary termination, permitted within the first 90 days of gestation. This deadline can only be exceeded in special cases, such as severe risk to the mother or fetal malformation. The Law 194/78 aims to ensure that the process of voluntary termination (IVG) is guaranteed, and in this sense, family planning clinics serve as a reference service for many women and couples. The organization of IVG services must be such that there is enough professional figures to provide women with access to voluntary pregnancy termination. From the latest reports published by the Ministry, there is a noticeable decrease in voluntary pregnancy terminations, a trend also observed among foreign women. This is undoubtedly influenced by the increased use of emergency contraception – Levonorgestrel (morning-after pill) and Ulipristal acetate (5-day after pill). On the other hand, due to the more frequent use of pharmacological termination (using Mifepristone+Prostaglandins), there is an increased access to termination within the first 8 weeks of gestation, which represents the deadline for undergoing this variant of the procedure. Materials and Methods: The study is retrospective and uncentered, with an evaluation of data from questionnaires administered to patients who underwent Pregnancy Terminations in the years 2020, 2021, and 2022 at San Giuliano Hospital in Giugliano in Campania (Na), which falls within the territory of the Local Health Authority Napoli 2 Nord.From the analysis of the questionnaires, it is possible to reconstruct sensitive patient data, including place and date of birth, residence, domicile, age, origin, education level, as well as all clinical data related to the patient and pregnancy in general. Surgical pregnancy termination compared to pharmacological termination appears to be less common in all three periods considered. The pharmacological method involves taking an antiprogesterone hormone (Mifepristone) followed by an analogue of prostaglandins (Misoprostol). From a cost analysis perspective, the starting point was the Diagnosis Related Group (DRG) of pharmacological and surgical pregnancy terminations in the Campania Region for each method considered. Results: The laboratory tests which the patient must undergo in the preliminary phase are the same in all abortion (IG) procedures. In the surgical treatment, the patient is admitted to the day hospital, and under anaesthesia, the gestational sac is removed (an invasive procedure with associated risks). In th
妊娠终止(IG)是一种广泛实践的临床程序,可以是治疗(IGT),药物(IGF)或手术(IGS)。分析与不同方法相关的总成本有助于突出患者的优势和劣势,并使决策者能够以具体数据支持的精确方式干预公司政策。关于终止妊娠的有关立法是第194/78号法律,其中特别提到在妊娠头90天内允许自愿终止妊娠。只有在特殊情况下,如对母亲有严重风险或胎儿畸形,才可以超过这个期限。第194/78号法律旨在确保自愿终止妊娠的过程得到保障,在这个意义上,计划生育诊所为许多妇女和夫妇提供了参考服务。试管婴儿服务的组织必须有足够的专业人员为妇女提供自愿终止妊娠的机会。从卫生部公布的最新报告来看,自愿终止妊娠的人数明显减少,在外国妇女中也有这种趋势。这无疑是受到紧急避孕药——左炔诺孕酮(事后避孕药)和醋酸乌普利司特(事后5天避孕药)使用增加的影响。另一方面,由于更频繁地使用药物终止(使用米非司酮+前列腺素),在妊娠前8周内终止妊娠的机会增加,这代表了进行这种手术的最后期限。材料和方法:该研究是回顾性的、非中心的,对坎帕尼亚(Na)朱里亚诺的圣朱利亚诺医院在2020年、2021年和2022年堕胎的患者进行问卷调查的数据进行了评估,该医院属于那不勒斯2北区地方卫生当局的领土。通过对问卷的分析,可以重建患者的敏感数据,包括出生地点和日期、居住地、住所、年龄、原籍、教育程度,以及与患者和妊娠相关的所有临床数据。与药物终止妊娠相比,手术终止妊娠在所有三个时期都不太常见。药理学方法包括服用抗孕酮激素(米非司酮),随后服用前列腺素类似物(米索前列醇)。从成本分析的角度来看,研究的起点是坎帕尼亚地区每种方法的药物和手术终止妊娠的诊断相关组(DRG)。结果:在所有人工流产(IG)程序中,患者在初始阶段必须进行的实验室检查是相同的。在手术治疗中,患者被送入日间医院,在麻醉下,取出妊娠囊(一种有相关风险的侵入性手术)。在药理学程序中,患者为服用两种具有不同活性成分的片剂和至少一次随访而到医院就诊三次。结论:虽然两个诊断相关组(drg)之间的差异很小,只有40欧元,但IGF的总支出更高,与IGC相比,IGF在病例数方面明显存在差异。另一方面,专业人员、技术和后勤基础设施的参与在IGF中是不一致的,而在IGC中则大得多。使用IGF,患者不需要进行任何麻醉评估或手术干预,恢复时间估计为几个小时,最重要的是,与手术相比,患者暴露于更少的风险。此外,与IGC相比,拥有所有干预技术的医疗保健人员和手术室结构参与IGF的程度较低,这可能导致公司在IGF中的边缘化程度更高,特别是考虑到所使用药物的实际成本。值得注意的是,DRG属于区域管辖范围,在整个国家领土上可能不尽相同。事实上,坎帕尼亚地区的情况可能与其他地区不同,导致IGC治疗的报销金额高于IGF。
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引用次数: 0
OBSERVATIONAL STUDY OF COSTS AND APPROPRIATENESS OF USE OF HEMOSTATIC DEVICES AND DRUGS IN DIFFERENT TYPES OF BLEEDING 不同类型出血中使用止血装置和药物的成本和适宜性的观察性研究
Pub Date : 2023-09-03 DOI: 10.36017/jahc202353249
Immacolata Filoso, Maria Rosaria Iacolare, Ida Monti, Attilio Tortora, Claudio Contiello, Assunta De Luca, Anna Scarano, Giovanni Gerbi, Gaetano Mignano, Lucio Marcello Falconio
Introduction:Bleedings can result from insufficient blood coagulation and represent a relevant clinical aspect in medical practice. In most cases, these are genetically determined disorders that persist throughout a person's life, leapractice. In most cases, these are genetically determined disorders that persist throughout a person's life, leading to a significant financial burden on the National Health System and affecting the patient's quality of life.On the other hand, the bleeding phenomenon can be influenced in its potential complications by various factors such as pharmacological therapies, autoantibodies, clinical situations, lifestyle, and other factors related to possible genetic predispositions. These undesirable effects pose a diagnostic and therapeutic challenge that often presents characteristics of urgency and severity due to disruptions in the patient's hemostatic balance.Pharmacological therapy with anticoagulants, whether they are heparin-based or NOACs, can affect the duration and quantity of bleeding. Therefore, it is essential to always inform the surgeon and the general practitioner before any procedure if the patient is on these medications. The replacement or discontinuation of these drugs should only be carried out under medical guidance, even if it's for preparing for minor or major surgical interventions. Stopping bleeding is an essential medical procedure, both in the operating room and in outpatient settings. The choice of hemostatic drug or device to use is based on the type of bleeding to be treated and can be a lifesaver for the patient, expediting the recovery process. Making the most appropriate choice promptly can lead to significant economic savings, making it an effective and efficient practice without wasteful decisions. Materials and Methods: The study is observational and multicentric, spanning over 36 months, with data collected from a cohort of 75,000 patients treated at the departments and clinics of the San Giuliano Hospital within the territory of ASL Napoli 2 Nord in the northern area of the Campania capital. The degree of bleeding from the lesions was classified based on a scale validated by the FDA, dividing the phenomenon into grades ranging from 0 to 4. Grade 0 refers to blood loss <1.0 mL/min, Grade 1 to bleeding between 1.0 < mL/min > 5.0, Grade 2 to bleeding between 5.0 < mL/min > 10.0, Grade 3 to bleeding between 10.0 < mL/min > 50.0, and Grade 4 to bleeding with blood loss > 50 mL/min. This division corresponds to a severity threshold and relative life-threatening risk based on the quantity of bleeding. Medical professionals who intervened or were responsible for follow-up visits were given a mini-questionnaire in which they were asked to classify the outcome success rate based on the percentage, assessing the cessation of bleeding considering the initial severity according to the FDA scale. The obtained responses were classified as perfect, good, sufficient, or failed based on the achieved o
简介:出血可能是由血液凝固不足引起的,在医学实践中是一个相关的临床方面。在大多数情况下,这些是遗传决定的疾病,持续整个人的一生,跳跃式练习。在大多数情况下,这些由基因决定的疾病会持续一生,给国家卫生系统带来重大的经济负担,并影响患者的生活质量。另一方面,出血现象可能受到各种因素的影响,如药物治疗、自身抗体、临床情况、生活方式和其他与可能的遗传易感性相关的因素。这些不良影响对诊断和治疗提出了挑战,通常由于患者止血平衡的破坏而表现出紧急和严重的特征。抗凝药物治疗,无论是基于肝素还是NOACs,都会影响出血的持续时间和数量。因此,如果病人正在服用这些药物,在任何手术前都必须告知外科医生和全科医生。这些药物的替换或停药应该在医疗指导下进行,即使是为小手术或大手术做准备。止血是一项基本的医疗程序,在手术室和门诊设置。止血药物或装置的选择是基于要治疗的出血类型,这对病人来说是一种救命药,可以加快恢复过程。及时做出最合适的选择可以节省大量的经济成本,使其成为有效和高效的实践,而不会浪费决策。材料和方法:该研究是观察性和多中心的,跨度超过36个月,数据收集自位于坎帕尼亚首都北部ASL那不勒斯2 Nord地区的圣朱利亚诺医院的部门和诊所的75,000名患者。病变出血的程度根据FDA验证的量表进行分类,将这种现象分为0到4级。0级为失血1.0 mL/min, 1级为出血1.0 mL/min;毫升/分钟的在5.0级,2级至5.0 &lt之间出血;毫升/分钟的在10.0, 3级至10.0 &lt之间出血;毫升/分钟的在50.0, 4级出血伴失血;50毫升/分钟。这种划分对应于严重程度阈值和基于出血量的相对危及生命的风险。干预或负责随访的医疗专业人员获得了一份小型问卷,要求他们根据百分比对结果成功率进行分类,根据FDA标准评估出血停止的初始严重程度。根据达到的结果,将获得的反应分为完美、良好、足够或失败,并与每个治疗使用的止血装置和/或药物类型相关。考虑的治疗包括止血装置和/或药物的总成本进行评估。最初失败的应对措施随后被重新分类为至少足够,以便了解治疗病例中不太一致的选择的经济影响和相关的财政支出。在评估从足够到完美的治疗的费用中,所有与需要修改治疗以改善结果的病例相关的费用已经包括在内。结果:在36个月的研究中,收集了75,000例病例的结果,每个病例都被归为FDA量表的一个等级。考虑到结果,观察到的反应是有效的,只有不到7%的人没有达到从完美到足够的水平。失败结果的阈值被故意设置得很高(阳性结果低于49%),以保持高水平的表现,以确保良好的平均治疗成功率。值得注意的是,在7%的失败回答中,只有2%的结果低于22%,这表明与平均积极标准有很大的偏差。结果受到出血治疗阶段的选择的影响,特别是考虑到每组的总数。这样就可以根据FDA的评分标准确定每个等级的最佳治疗选择。因此,对于只有失血的0级病例,胶粘剂被划分为完美级;对于2级病例,止血贴片被划分为完美级;对于有严重生命危险的4级病例,带有凝血酶和凝血因子的手术辅助剂被划分为完美级。止血粉末和敷料在1级病例中被评为足够,而在3级病例中止血基质表现良好。 当考虑到对单个观察响应的总成本的百分比影响时,发现完美响应占43%,而失败响应占10%。总之,治疗无效的平均费用约为13.5万欧元。还计算了与改变治疗方法以改善最初获得的疗效相关的费用。结论:适当的出血类型分类可以快速干预,并在选择合适的医疗设备和/或药物方面具有更高的准确性。通过使用fda认证的出血量表,可以快速获得患者生命的最佳结果,这对他们的康复非常重要。同时,在使用药物和/或设备止血方面做出正确的选择,可以对相应治疗进行持续的成本监测,在控制成本的同时实现效率和效果。36个月内,在包括圣朱利亚诺医院急诊室和门诊部在内的各部门进行了75 000次观察到的出血治疗,总费用约为150万欧元。通过有针对性地选择最合适的治疗方法,可以节省大约15万欧元。
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引用次数: 0
THE PHARMAECONOMIC EVALUATION OF PAPER DRUG AND MEDICAL DEVICE UTILIZATION AS A TOOL FOR ASSESSING ORGANIZATIONAL PERFORMANCE 纸质药品和医疗器械利用的药物经济学评价作为评估组织绩效的工具
Pub Date : 2023-09-03 DOI: 10.36017/jahc202353245
Lucio Marcello Falconio
PREFACE
前言
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引用次数: 0
INCIDENCE ON COST AND DURATION OF THERAPY OF POSSIBLE POSTOPERATIVE WOUND INFECTIONS FROM TRAUMA WITH PROSTHETIC DEVICES, PREVENTIVELY TREATED AND UNTREATED, USING ANTIBACTERIAL GELS AT P.O. SAN GIULIANO, ASL NAPLES 2 NORTH 在那不勒斯2北部SAN giuliano p.o,预防性治疗和未治疗的情况下,使用抗菌凝胶治疗创伤术后伤口感染的成本和持续时间的发生率
Pub Date : 2023-09-03 DOI: 10.36017/jahc202353250
Immacolata Filoso, Maria Rosaria Iacolare, Ida Monti, Attilio Tortora, Claudio Contiello, Assunta De Luca, Anna Scarano, Giovanni Gerbi, Gaetano Mignano, Lucio Marcello Falconio
Introduction: Bacterial infections associated with implanted biomaterials represent the most significant complication in orthopedics, and they constitute the primary reason for the failure of primary hip and knee prostheses.The prevention of infections associated with implanted biomaterials should simultaneously focus on at least two objectives: inhibition of biofilm formation and minimization of suppression of the local immune response.Some of the technologies proposed for this purpose in clinical practice have already shown strong evidence of antibacterial effectiveness, safety, and resistance. The time is ripe for further development and experimentation of these technologies in a clinical context. Material and Methods: The study was conducted by observing wounds within 6 months following the treatments, and the purpose of the work was to evaluate the cost and benefit aspects in patients treated with defensive antibacterial gels during orthopedic prosthetic and/or synthesis surgeries at the P.O. San Giuliano ASL Napoli 2 Nord. The aim was to assess the effectiveness of the treatment applied to patients who underwent orthopedic prosthetic and/or synthesis surgeries. The wound conditions of treated patients and untreated patients were compared at 6 months after orthopedic surgery. Simultaneously, the costs incurred by the National Health Service (SSN) and the related benefits obtained for the treated patients and untreated patients were also analyzed. This observational and retrospective study was conducted over 6 months on a cohort of 60 patients from the orthopedic department and outpatient clinic of P.O. San Giuliano ASL Napoli 2, who underwent post-traumatic interventions. The cohort was divided into two groups: Group A (gA) included 30 operated patients whose wounds and/or devices used were treated with gels designed for decontamination, aiming to prevent infections; Group B (gB) consisted of 30 operated patients who were not treated with any such device. The study involved a 6-month observation of both groups, evaluating the possible onset of infections, their duration (until complete healing, including potential complications), and the average cost of the necessary treatment (monitoring the use of drugs, medical supplies, and devices).A value scale was established based on the average cost incurred and the average treatment duration for each of the 4 levels on the scale. Results: At the end of the study period, 30 patients from the cohort were observed in group gA, and 30 in group gB.Within group gA, 2 patients experienced infections that positioned them in the first two levels of the scale, while in group gB, 8 patients required treatment for infections that placed them at different levels of the scale based on the treatment received and its associated cost. The economic impact is significant and variable, depending on the extent of usage indications (e.g., applying the device alone or as a carrier in combination with antibiotics in all s
导读:与植入生物材料相关的细菌感染是骨科中最重要的并发症,也是原发性髋关节和膝关节假体失败的主要原因。预防与植入生物材料相关的感染应同时关注至少两个目标:抑制生物膜的形成和尽量减少对局部免疫反应的抑制。在临床实践中,为此目的提出的一些技术已经显示出抗菌有效性、安全性和耐药性的有力证据。在临床环境中进一步开发和试验这些技术的时机已经成熟。材料和方法:本研究通过观察治疗后6个月内的伤口进行,目的是评估P.O.圣朱利亚诺ASL那不勒斯2 Nord骨科假体和/或合成手术中使用防御性抗菌凝胶治疗的患者的成本和收益方面。目的是评估应用于接受矫形假体和/或合成手术的患者的治疗效果。比较矫形术后6个月治疗组和未治疗组的伤口情况。同时,还分析了国民保健服务(SSN)的费用以及治疗患者和未治疗患者获得的相关利益。这项观察性和回顾性研究对来自P.O.圣朱利亚诺ASL那不勒斯2医院骨科和门诊的60名患者进行了为期6个月的队列研究,这些患者接受了创伤后干预。该队列分为两组:A组(gA)包括30名手术患者,其伤口和/或使用的器械使用了用于消毒的凝胶,旨在预防感染;B组(gB)包括30例未使用任何此类装置的手术患者。该研究对两组患者进行了为期6个月的观察,评估可能发生的感染、感染持续时间(直到完全愈合,包括潜在的并发症)以及必要治疗的平均费用(监测药物、医疗用品和设备的使用)。根据量表上4个级别的平均费用和平均治疗时间建立价值量表。结果:研究期结束时,gA组30例,gB组30例。在gA组中,有2名患者经历了感染,处于量表的前两个级别,而在gB组中,有8名患者需要治疗感染,根据所接受的治疗及其相关费用,将他们置于不同的级别。经济影响是显著的和可变的,这取决于使用适应症的程度(例如,在所有接受初级和翻修性关节置换术的受试者中单独使用该装置或作为载体与抗生素联合使用,或仅在其中的一部分,例如,选择有感染风险的患者,接受假体再植的受试者,开放性创伤性骨折的骨融合术等)。结论:骨科假体和/或综合手术后发生的感染的处理导致患者寻求并依赖长期的医疗随访和专业护理协助。保健的总成本的10个受感染的病人显示总体支出相关的8 gB组患者远高于总在gA组2例,因为五倍的差别就数量而言,它演示了如何用抗菌凝胶治疗可以减少感染的发生率,也因为感染发生在2组患者的情况下遗传算法是温和的和更易于管理。考虑到在伤口和/或假体/骨固定装置上使用抗菌凝胶的相关成本,考虑到感染及其潜在并发症的药物治疗成本,经济节省仍然是显著的。
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引用次数: 0
MONITORING OF AIRBORNE FIBERS DURING ASBESTOS REMEDIATION: THE CASE STUDY OF THE “ETERNIT” SITE IN THE BAGNOLI-COROGLIO AREA OF RELEVANT NATIONAL INTEREST 石棉修复过程中的空气传播纤维监测:巴格诺里-科罗格里奥国家相关利益区 "ETERNIT "遗址案例研究
Pub Date : 2023-09-01 DOI: 10.36017/jahc202352280
Edoardo Robortella Stacul, Giuseppe Napolitano, Davide Gresia, Lorenzo Morra, Carmen Fiore, Fabiana Saraceno
As part of the broader implementation of the Environmental Remediation and Urban Regeneration Program (PRARU) of the Bagnoli-Coroglio area of relevant national interest (Naples, Italy), one of the priority actions was the completion of the soil remediation interventions of the former Eternit site, focused on the safe removal of soil and materials containing asbestos still present in the area (approximately 25,700 tonnes of hazardous waste).This area has an extension of approximately 157,000 m2 where the production of products containing asbestos had been carried out from 1939 to 1985. In 1997, the first reclamation activities began, consisting of the decommissioning of industrial structures and continuing with the removal of buried materials. These activities were interrupted in 2014 and then resumed in 2020 until completion at the beginning of 2023.The activities, completed to date, were run under the constant control of the territorially competent “ASL Napoli 1”, and with the implementation of a specific shared plan for monitoring airborne fibers both inside the construction site and outside in the surrounding areas.In particular, environmental monitoring activities were performed before, during and post-operation on eight control units, three of which were located within the construction site and five in the surrounding areas at potentially sensitive targets, as well as personal sampling of the exposed operators.The methods for identifying asbestos fibers were both phase contrast microscopy (MOCF) and scanning electron microscopy (SEM).In both cases, the monitoring results never showed that the thresholds established by Italian legislation were exceeded, both in terms of total fibers and asbestiform fiber.
作为更广泛地实施巴尼奥利-科罗格里奥(Bagnoli-Coroglio)国家有关地区(意大利那不勒斯)环境整治和城市复兴计划(PRARU)的一部分,优先行动之一是完成 Eternit 公司旧址的土壤整治干预措施,重点是安全清除该地区仍然存在的含石棉土壤和材料(约 25,700 吨危险废物)。1997 年,开始了第一批复垦活动,包括拆除工业结构和继续清除掩埋材料。这些活动于 2014 年中断,然后于 2020 年恢复,直至 2023 年初完成。迄今为止完成的这些活动是在领土主管机构 "ASL Napoli 1 "的持续控制下进行的,并实施了一项专门的共享计划,用于监测建筑工地内外及周边地区的空气传播纤维。特别是,在八个控制单元(其中三个位于建筑工地内,五个位于周边地区的潜在敏感目标处)的运行前、运行中和运行后都进行了环境监测活动,并对暴露在空气中的操作人员进行了个人取样。在这两种情况下,监测结果从未显示总纤维和石棉状纤维超过意大利法律规定的阈值。
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引用次数: 0
ANALYSIS AND EVALUATION OF THE IMPACT OF COVID-19 ON THE COMPLEX SYSTEM OF THE 19 TSRM AND PSTRP HEALTH PROFESSIONS. 分析和评估 COVID-19 对 19 个 tsrm 和 pstrp 卫生专业复杂系统的影响。
Pub Date : 2023-07-18 DOI: 10.36017/jahc202352224
Claudia Nissi
In the pandemic emergency, work-related stress in paramedical professions has reached levels never imagined before. A questionnaire was administered to understand the stress or burnout, generated by the Covid 19 pandemic. The psychological theory  reported explains the results that emerged and the correlations with the factors that intensified the impact of stress, to  produce burnout situations among health professionals.
在大流行病的紧急情况下,辅助医务人员的工作压力达到了前所未有的程度。为了了解 Covid 19 大流行病所产生的压力或职业倦怠,我们进行了一次问卷调查。所报告的心理学理论解释了出现的结果以及与加剧压力影响的因素之间的相关性,从而在卫生专业人员中产生倦怠情况。
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引用次数: 0
Home Radiology Activities In Asl Bt As An Example Of Integration Between Hospital And Territory. FuturePerspectivesIn The Light Of Pnrr. Asl - Bt家庭放射活动:医院与地区整合的一个例子。未来的前景在Pnrr的光。
Pub Date : 2023-06-20 DOI: 10.36017/jahc202351134
Giovanna Albanese, Maria Urbano, Giuseppe Walter Antonucci, Giacinto Abruzzese, Giuseppe Guglielmi
The National Recovery and Resilience Plan (NRP) is a plan approved in 2021 to relaunch the economy after the COVID-19 pandemic and provides for an investment and reform package divided into six Missions, including Health. The recent pandemic has clearly demonstrated how the Hospital/Territory axis has not been able to withstand the impact of an event such as the COVID pandemic. With a view to an overall improvement of the system, the PNRR gives us the opportunity to intervene by completely redesigning the territorial health and the goal is to compensate for the current territorial care inequalities and bridge the distance between the traditional places of care and the daily life of the patient, strengthening the health and social health network in the territory with better primary care services.In this context, Home Radiology, a branch of radiology, is inserted, which deals with all procedures aimed at performing traditional radiographic examinations at the home of the non-ambulatory and / or non-transportable patient on the basis of clinical evaluations.To validate the activity of Home Radiology, in this experimental study, radiographic examinations performed at home were compared with radiographic examinations performed in the hospital with the aim of highlighting that this method is desirable and mature to be spread and used in the Territory.Through a blind analysis by some hospital Radiologists, in fact, it is shown that the examinations performed at the patient’s home are, practically, superimposable to those performed in an outpatient setting.
国家恢复和复原力计划(NRP)是2021年批准的一项计划,旨在在2019冠状病毒病大流行后重新启动经济,并提供了一个投资和改革一揽子计划,分为包括卫生在内的六个任务。最近的大流行清楚地表明,医院/地区轴无法承受COVID大流行等事件的影响。为了全面改进该系统,PNRR使我们有机会通过完全重新设计地区保健进行干预,其目标是弥补目前的地区保健不平等现象,弥合传统护理场所与患者日常生活之间的距离,通过更好的初级保健服务加强领土的保健和社会保健网络。在这种情况下,家庭放射学,放射学的一个分支,被插入,它处理所有的程序,旨在执行传统的放射检查,在家里的非流动和/或不能移动的病人在临床评估的基础上。为了验证家庭放射学的活动,在这项实验性研究中,将在家进行的放射检查与在医院进行的放射检查进行了比较,目的是强调这种方法是可取的和成熟的,可以在领土推广和使用。事实上,通过一些医院放射科医生的盲目分析,结果表明,在病人家中进行的检查实际上与在门诊进行的检查是重叠的。
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引用次数: 0
EFFECTIVENESS OF COUGH ASSIST IN THE EXTUBATION OF ADULT PATIENTS: SYSTEMATIC REVIEW AND META-ANALYSIS 咳嗽辅助成人患者拔管的有效性:系统回顾和荟萃分析
Pub Date : 2023-06-11 DOI: 10.36017/jahc202351277
Giulia Montigiani, Davide Papi, Lorenzo Proietti, Beatrice Meucci, Mara Taddei, Luca Bucciardini, Mauro Di Bari
In Intensive Care Unit (ICU), failure of extubation, resulting in the need for reintubation, mayoccur in 2-25% of Patients undergoing extubation[1]. The purpose of this review and meta-analysiswas to determine the effectiveness of cough assist in improving success rates of extubation compared with standard treatment. Inclusion criteria were; Randomized Control Trials, which compared cough assist and conventional therapy in adult population in intensive care unit whith conventional therapy only. Outcomes representing the efficacy of the cough assist were: quantity and quality of secretions (weight, volume, and density), number of reintubation, indices of thoraco-pulmonary function. The search string produced 764 studies, and only 5 studies eligible for review. Overall, a total of 331 participants were enrolled in the five studies selected. Of the meta-analyzed outcomes, the calculation of the effect size for the weight of secretions is the one that gave the best results, while no statistical difference was found in the other outcomes. In none of the meta-analysis studies were observed adverse effects in the use of in-exsufflator. Our systematically review edsuggest sthatcough assist might be feasible and effective in patients intubated in ICU, but studies with larger sample sizes and well-defined outcomes are still required to obtain conclusive evidence.
在重症监护病房(ICU), 2-25%的拔管患者可能出现拔管失败,导致需要重新插管[1]。本综述和荟萃分析的目的是确定与标准治疗相比,咳嗽辅助治疗在提高拔管成功率方面的有效性。 纳入标准为;随机对照试验,比较重症监护病房成人咳嗽辅助治疗和常规治疗与常规治疗。代表咳嗽辅助治疗效果的结果是:分泌物的数量和质量(重量、体积和密度)、再插管次数、胸肺功能指标。 搜索字符串产生了764项研究,只有5项研究符合审查条件。总的来说,共有331名参与者被纳入了所选的五项研究。 在meta分析的结果中,对分泌物重量的效应大小的计算给出了最好的结果,而在其他结果中没有发现统计学差异。在所有meta分析研究中,均未观察到使用呼气机的不良反应。 我们的系统综述表明,在ICU插管患者中,止咳辅助可能是可行和有效的,但仍需要更大样本量和明确结果的研究来获得结论性证据。
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引用次数: 0
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Journal of Advanced Health Care
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