Within the northwestern Desert of Egypt, the Beni Suef Basin is one of the most significant hydrocarbon basins. After over 50 years of exploration and production, the main challenge today is to locate new areas that are prolific to oil and gas production. The study aims to identify potential drilling locations by integrating geochemical methods, 1D and 2D basin modelling, well log analysis, seismic interpretation, and hydrocarbon migration pathways. Results show that the Lower Kharita shale contain both oil and gas generating kerogen with generating potential that ranges from fair to very good. The source rocks within the Lower Kharita are mature (main oil window) and have a transformation ratio of up to 60% based on 1D basin modeling. The modelled 2D vitrinite reflectance map showed that hydrocarbon generation occurred at depths greater than 10850 ft (3306 m) with vitrinite reflectance values greater than 0.65% in both the northern and southern parts of the Beni Suef Field. Two main reservoirs were studied. The lower Bahariya and upper Kharita reservoirs are composed of well to moderately sorted sandstone. The subsurface structural maps, reservoirs, source, and charge modeling maps have been constructed to show the migration pathways and accumulation areas. There are three accumulation areas identified. The first accumulation area is located in the high structure up-dip section of the major normal fault, and migration direction is from northwest. The second and third accumulation areas are located in the low structure and down-dip from the normal fault, with migration of hydrocarbons from southeast. The latter two areas should be tested by drilling in the future.