Objectives: The purpose of this study is to compare ultraviolet (UV) illumination with traditional white light for locating fluorescent-tagged adhesive residues during orthodontic debonding, and to draw conclusions about whether kind of lighting is more successful and efficient. Materials and Methods: The extracted human premolars were bonded to orthodontic brackets using one of two fluorescent bonding resins (Pad Lock, Reliance Orthodontics, Itasca, Ill.;). Opal Bond MV, Opal Orthodontics, South Jordan, Utah; $40 a pop).” After debonding, the operatory light was used to illuminate most of the teeth in each paste bundle (n = 20), while an ultraviolet (395 nm) light release diode (Drove) spotlight illuminated the remaining teeth. Cleaning one's teeth took a certain amount of time, which was recorded. The surface area of adhesive remains was determined by taking follow-up photographs with a dissecting microscope under UV light. The effectiveness of cement removal was also investigated using scanning electron microscopy. We used an ANOVA and a Kruskal-Wallis test to compare the two variables, time and adhesive residue. Results: Using a dissecting microscope, researchers determined that there were considerably less adhesive remains in the UV light group compared to the white light group (P .01). Opal Bond MV glue removed in much less time (P .01) when exposed to UV light as opposed to white light. Scanning electron microscopy analysis revealed invisible to UV light, minute adhesive residues (2 m). Conclusions: When it comes to spotting fluorescent adhesive during orthodontic debonding, ultraviolet light is both more effective and more efficient than white light. UV LED illumination is a useful tool for finding adhesives, despite its drawbacks.
{"title":"AN IN VITRO COMPARISON OF ULTRAVIOLET VERSUS WHITE LIGHT IN THE DETECTION OF ADHESIVE REMNANTS DURING ORTHODONTIC DEBONDING","authors":"Dr. M Reddy Pradeep","doi":"10.58935/joas.v2i1.23","DOIUrl":"https://doi.org/10.58935/joas.v2i1.23","url":null,"abstract":"Objectives: The purpose of this study is to compare ultraviolet (UV) illumination with traditional white light for locating fluorescent-tagged adhesive residues during orthodontic debonding, and to draw conclusions about whether kind of lighting is more successful and efficient. \u0000Materials and Methods: The extracted human premolars were bonded to orthodontic brackets using one of two fluorescent bonding resins (Pad Lock, Reliance Orthodontics, Itasca, Ill.;). Opal Bond MV, Opal Orthodontics, South Jordan, Utah; $40 a pop).” After debonding, the operatory light was used to illuminate most of the teeth in each paste bundle (n = 20), while an ultraviolet (395 nm) light release diode (Drove) spotlight illuminated the remaining teeth. Cleaning one's teeth took a certain amount of time, which was recorded. The surface area of adhesive remains was determined by taking follow-up photographs with a dissecting microscope under UV light. The effectiveness of cement removal was also investigated using scanning electron microscopy. We used an ANOVA and a Kruskal-Wallis test to compare the two variables, time and adhesive residue. \u0000Results: Using a dissecting microscope, researchers determined that there were considerably less adhesive remains in the UV light group compared to the white light group (P .01). Opal Bond MV glue removed in much less time (P .01) when exposed to UV light as opposed to white light. Scanning electron microscopy analysis revealed invisible to UV light, minute adhesive residues (2 m). \u0000Conclusions: When it comes to spotting fluorescent adhesive during orthodontic debonding, ultraviolet light is both more effective and more efficient than white light. UV LED illumination is a useful tool for finding adhesives, despite its drawbacks.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75170263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the past three decades, teledentistry has grown as a way for dental professionals to connect with one another from afar. It enables collaboration between different practitioners when it comes to a patient and the required care for this patient. With rural communities or those of underserved populations, teledentistry can be quite useful. Along with reducing the time and expense involved with speciality consultations, it would boost the accessibility of specialists.
{"title":"TELEDENTISTRY FOR IMPROVING ORAL HEALTH OF RURAL INDIA","authors":"Dr. Anuja Pathak","doi":"10.58935/joas.v2i1.17","DOIUrl":"https://doi.org/10.58935/joas.v2i1.17","url":null,"abstract":"In the past three decades, teledentistry has grown as a way for dental professionals to connect with one another from afar. It enables collaboration between different practitioners when it comes to a patient and the required care for this patient. With rural communities or those of underserved populations, teledentistry can be quite useful. Along with reducing the time and expense involved with speciality consultations, it would boost the accessibility of specialists.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90616081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Prasanna Kumar D., Dr. Nidhi Jenson Ukken, Dr. H K Ajeya Ranganathan, Dr. Mohammed Basim, Dr.Mariea Francis, Dr. Vijay Joseph Chethalan
Goltz Gorlin syndrome (GGS) is an multisystemic disease with an autosomal dominant disorder, with complete variance, though irregular cases have been described. This article includes a case report and an extensive review of the GGS with regard to its history, incidence, etiology, features, investigations, diagnostic criteria, keratocystic odontogenic tumor and treatment modalities. case of a 32-year-old female patient presenting with three major features of Gorlin-Goltz syndrome. Radiologic findings of the syndrome are easily identifiable on Orthopantomogram, cbct scans. These investigations prompt an early verification of the disease, which is very important to prevent recurrence and better survival rates from the coexistent diseases.
{"title":"GOLTZ GORLIN SYNDROME- A CASE REPORT WITH OVERVIEW","authors":"Dr. Prasanna Kumar D., Dr. Nidhi Jenson Ukken, Dr. H K Ajeya Ranganathan, Dr. Mohammed Basim, Dr.Mariea Francis, Dr. Vijay Joseph Chethalan","doi":"10.58935/joas.v1i2.16","DOIUrl":"https://doi.org/10.58935/joas.v1i2.16","url":null,"abstract":"Goltz Gorlin syndrome (GGS) is an multisystemic disease with an autosomal dominant disorder, with complete variance, though irregular cases have been described. This article includes a case report and an extensive review of the GGS with regard to its history, incidence, etiology, features, investigations, diagnostic criteria, keratocystic odontogenic tumor and treatment modalities. case of a 32-year-old female patient presenting with three major features of Gorlin-Goltz syndrome. Radiologic findings of the syndrome are easily identifiable on Orthopantomogram, cbct scans. These investigations prompt an early verification of the disease, which is very important to prevent recurrence and better survival rates from the coexistent diseases.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87255128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Ayushi Sharma, Dr. Sahana. S, Dr. Garima Bhambhani, Dr. Anuja Pathak, Anupam Sharma
COVID 19 or corona virus is a RNA virus and firstly it was discovered in WUHAN, CHINA on 31st December 2019. SARS COV-2 is responsible for COVID 19 occurrence. A suggested route of humanto-human transmission is through airborne droplets, touching or coming into contact with an infected person or a contaminated surface A large number of medical staff were reported to have acquired the disease while working with infected individuals. The dental clinic is not an exception for a similar possibility of transmitting and acquiring the infection between staff or individuals; moreover, the dental clinic could be a riskier environment for spreading the virus because of the close contact with patients and the nature of the dental treatment. So the aim of the study was to evaluate the perception and attitude regarding covid-19 infection among dental students Methods: Post graduate students and interns of a dental college in Central India were selected.184 individuals in total were chosen, with 80 postgraduates overall and around 104 interns. Data was collected using an online questionnaire employing Google Forms. The questionnaires was distributed using social media platform like facebook, WhatsApp etc. Chi square test was used to evaluate perception and attitude regarding covid-19 infection among post graduates and interns and the the data obtained were subjected to statistical analysis using Statistical Package for the Social Sciences (SPSS Version 23; Chicago Inc., IL, USA). Results: This study found that dental students are well-aware of effects of expected SARS-CoV-2 infection transmission in a clinical setting. It also came to the conclusion that postgraduates have a somewhat more positive attitude regarding the illness than interns do. Conclusion: The dentist and dental students must be aware of the effects of expected SARS-CoV-2 infection transmission in a clinical setting. They must therefore stay up to date on any updated information regarding this ailment which help them and their patients to be safe while treatment.
COVID - 19或冠状病毒是一种RNA病毒，于2019年12月31日首次在中国武汉被发现。SARS COV-2是导致COVID - 19发生的原因。建议的人际传播途径是通过空气飞沫、接触或接触感染者或受污染的表面。据报告，大量医务人员在与感染者一起工作时感染了该病。牙科诊所也不例外，在工作人员或个人之间传播和获得感染的可能性类似;此外，由于与病人密切接触以及牙科治疗的性质，牙科诊所可能是传播病毒的更危险环境。因此，本研究的目的是评估牙科学生对covid-19感染的认知和态度。方法:选择印度中部一所牙科学院的研究生和实习生。共有184人入选，其中研究生80人，实习生104人。数据是通过使用谷歌表格的在线问卷收集的。问卷通过facebook、WhatsApp等社交媒体平台发放。采用卡方检验评估研究生和实习生对covid-19感染的认知和态度，并使用SPSS Version 23对所得数据进行统计分析;芝加哥公司，伊利诺伊州，美国)。结果:本研究发现，牙科学生很清楚在临床环境中预期的SARS-CoV-2感染传播的影响。研究还得出结论，研究生对疾病的态度比实习生更积极。结论:在临床环境中，牙医和牙科学生必须意识到预期的SARS-CoV-2感染传播的影响。因此，他们必须及时了解有关这种疾病的任何最新信息，以帮助他们和他们的病人在治疗期间保持安全。
{"title":"PERCEPTION AND ATTITUDE REGARDING COVID-19 INFECTION AMONG DENTAL STUDENTS","authors":"Dr. Ayushi Sharma, Dr. Sahana. S, Dr. Garima Bhambhani, Dr. Anuja Pathak, Anupam Sharma","doi":"10.58935/joas.v1i2.12","DOIUrl":"https://doi.org/10.58935/joas.v1i2.12","url":null,"abstract":"COVID 19 or corona virus is a RNA virus and firstly it was discovered in WUHAN, CHINA on 31st December 2019. SARS COV-2 is responsible for COVID 19 occurrence. A suggested route of humanto-human transmission is through airborne droplets, touching or coming into contact with an infected person or a contaminated surface A large number of medical staff were reported to have acquired the disease while working with infected individuals. The dental clinic is not an exception for a similar possibility of transmitting and acquiring the infection between staff or individuals; moreover, the dental clinic could be a riskier environment for spreading the virus because of the close contact with patients and the nature of the dental treatment. So the aim of the study was to evaluate the perception and attitude regarding covid-19 infection among dental students \u0000Methods: Post graduate students and interns of a dental college in Central India were selected.184 individuals in total were chosen, with 80 postgraduates overall and around 104 interns. Data was collected using an online questionnaire employing Google Forms. The questionnaires was distributed using social media platform like facebook, WhatsApp etc. Chi square test was used to evaluate perception and attitude regarding covid-19 infection among post graduates and interns and the the data obtained were subjected to statistical analysis using Statistical Package for the Social Sciences (SPSS Version 23; Chicago Inc., IL, USA). \u0000Results: This study found that dental students are well-aware of effects of expected SARS-CoV-2 infection transmission in a clinical setting. It also came to the conclusion that postgraduates have a somewhat more positive attitude regarding the illness than interns do. \u0000Conclusion: The dentist and dental students must be aware of the effects of expected SARS-CoV-2 infection transmission in a clinical setting. They must therefore stay up to date on any updated information regarding this ailment which help them and their patients to be safe while treatment.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76551111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Nikhil Chandrakant Thorat,, Dr. Sahana. S, Dr. Tarun Pratap Singh, Dr. Anshika Khare, Dr. Priyanka Paliwal
Introduction - Coronavirus Disease 2019 (COVID-19) is caused by the SARS Corona Virus 2 (SARSCOV 2), which was discovered in 2019 at a wet market in Wuhan, China. Healthcare workers' psychological health has been significantly impacted by the coronavirus disease. During epidemics, health care workers (HCWs) are commonly the very first point of contact and are vulnerable to infectious diseases. The aim of the study to measure the psychological effect of Covid-19 amongst healthcare workers in Bhopal city. Materials and methods- A cross-sectional questionnaire-based study was conducted amongst health care workers of Bhopal city, who were working in government and private hospitals between April 2021 to May 2021. The Depression, Anxiety, and Stress Scale - 21(DASS-21) Items was used to conduct the survey Data analysis was done using SPSS Statistics for Windows, version 22.0 (SPSS Inc., Chicago, Ill., USA). ANOVA test was used to determine to find any significant difference comparing psychological variable between the groups of health care workers. P value < 0.05 was considered statistically significant. Results- 350 responses were received in total. Health care workers were categorised as doctors, dentists and nurses. Among the respondents 20.9% participants were males and 79.1% were females. It was noted that dentists reported significantly more psychological distress than doctors and nurses. At baseline (n=350), overall mean depression, anxiety and stress of the doctor, dentist and nurses were 20.69±7.55, 29.83±8.34 and 12.86±4.69 respectively, which was significant at p=0.00*. Conclusion – Health care workers experienced poor psychological health due to pandemic, indicating they may be at risk for greater psychological distress. The results of this study stress the greater need of research in psychological field to facilitate capacity building among healthcare workers.
2019冠状病毒病(COVID-19)是由2019年在中国武汉的一个菜市场发现的SARS冠状病毒2 (SARSCOV 2)引起的。新冠肺炎疫情对医护人员的心理健康造成了显著影响。在流行病期间，卫生保健工作者通常是第一个接触点，容易感染传染病。该研究的目的是测量Covid-19对博帕尔市医护人员的心理影响。材料和方法——在2021年4月至2021年5月期间在政府和私立医院工作的博帕尔市卫生保健工作者中进行了一项基于横断面问卷的研究。使用抑郁、焦虑和压力量表-21 (DASS-21)项目进行调查。数据分析使用SPSS Statistics for Windows, version 22.0 (SPSS Inc.， Chicago, illinois)。美国)。采用方差分析(ANOVA)检验，比较医护人员群体间的心理变量是否存在显著差异。P值< 0.05为差异有统计学意义。结果-共收到350份回复。保健工作者分为医生、牙医和护士。受访者中男性占20.9%，女性占79.1%。值得注意的是，牙医报告的心理困扰明显多于医生和护士。基线时(n=350)，医生、牙医和护士的总体平均抑郁、焦虑和压力分别为20.69±7.55、29.83±8.34和12.86±4.69,p=0.00*差异有统计学意义。结论:卫生保健工作者由于大流行经历了较差的心理健康状况，表明他们可能面临更大的心理困扰风险。本研究结果强调心理领域的研究更有必要促进医护人员的能力建设。
{"title":"PSYCHOLOGICAL EFFECT OF COVID-19 AMONGST HEALTH-CARE WORKERS IN BHOPAL, MADHYAPRADESH.","authors":"Dr. Nikhil Chandrakant Thorat,, Dr. Sahana. S, Dr. Tarun Pratap Singh, Dr. Anshika Khare, Dr. Priyanka Paliwal","doi":"10.58935/joas.v1i2.13","DOIUrl":"https://doi.org/10.58935/joas.v1i2.13","url":null,"abstract":"Introduction - Coronavirus Disease 2019 (COVID-19) is caused by the SARS Corona Virus 2 (SARSCOV 2), which was discovered in 2019 at a wet market in Wuhan, China. Healthcare workers' psychological health has been significantly impacted by the coronavirus disease. During epidemics, health care workers (HCWs) are commonly the very first point of contact and are vulnerable to infectious diseases. The aim of the study to measure the psychological effect of Covid-19 amongst healthcare workers in Bhopal city. \u0000Materials and methods- A cross-sectional questionnaire-based study was conducted amongst health care workers of Bhopal city, who were working in government and private hospitals between April 2021 to May 2021. The Depression, Anxiety, and Stress Scale - 21(DASS-21) Items was used to conduct the survey Data analysis was done using SPSS Statistics for Windows, version 22.0 (SPSS Inc., Chicago, Ill., USA). ANOVA test was used to determine to find any significant difference comparing psychological variable between the groups of health care workers. P value < 0.05 was considered statistically significant. \u0000Results- 350 responses were received in total. Health care workers were categorised as doctors, dentists and nurses. Among the respondents 20.9% participants were males and 79.1% were females. It was noted that dentists reported significantly more psychological distress than doctors and nurses. At baseline (n=350), overall mean depression, anxiety and stress of the doctor, dentist and nurses were 20.69±7.55, 29.83±8.34 and 12.86±4.69 respectively, which was significant at p=0.00*. \u0000Conclusion – Health care workers experienced poor psychological health due to pandemic, indicating they may be at risk for greater psychological distress. The results of this study stress the greater need of research in psychological field to facilitate capacity building among healthcare workers.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75100824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Local anaesthetics (LAs) offer patients pain-free dental care while lowering patient apprehension and anxiety. Evidence-based dental clinical practice should be based on the most recent clinical studies and involve ongoing reevaluation of all available clinical data on the efficacy and safety of dental anaesthetics. When dealing with children, it is imperative to understand the overdosage of anesthetic agents resulting in toxic reactions and soft tissue trauma inflicted due to extended spans of anesthesia and variations of technique. The anaesthesia should have minimal side effects and optimal efficacy with the fewest injections possible. Hence, this review has been undertaken to assess the various parameters related to Articaine, the newer anesthetic.
{"title":"A COMPREHENSIVE REVIEW ON ARTICAINE","authors":"Dr.Parimala Kulkarni","doi":"10.58935/joas.v1i2.11","DOIUrl":"https://doi.org/10.58935/joas.v1i2.11","url":null,"abstract":"Local anaesthetics (LAs) offer patients pain-free dental care while lowering patient apprehension and anxiety. Evidence-based dental clinical practice should be based on the most recent clinical studies and involve ongoing reevaluation of all available clinical data on the efficacy and safety of dental anaesthetics. When dealing with children, it is imperative to understand the overdosage of anesthetic agents resulting in toxic reactions and soft tissue trauma inflicted due to extended spans of anesthesia and variations of technique. The anaesthesia should have minimal side effects and optimal efficacy with the fewest injections possible. Hence, this review has been undertaken to assess the various parameters related to Articaine, the newer anesthetic.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73162201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Devi Anjana, Dr. Rahul Srivastava, D. Mehrotra, Dr.Kriti Garg
The oral cavity is the mirror of systemic health. Anemia is one such condition, which manifests itself in the oral cavity. According to the World Health Organization, the normal haemoglobin level for an adult male is around 13.8 g/dl and for an adult woman is around 12.1 g/dl. Anemia is defined as when the haemoglobin level in the blood is below the lower extreme of the normal range for the age and sex of the individual. Iron deficiency anaemia is the most common nutritional deficiency disorder in children and women and is worldwide in distribution. It is characterised by fatigue, weakness, pallor, and koilonychias. Thus, oral physicians play an important role in diagnosis and thereby prevention of anemia, as oral manifestations may be the earliest feature of the condition.
{"title":"IRON DEFICIENCY ANEMIA AND ITS ORAL MANIFESTATION -A REVIEW","authors":"Devi Anjana, Dr. Rahul Srivastava, D. Mehrotra, Dr.Kriti Garg","doi":"10.58935/joas.v1i2.14","DOIUrl":"https://doi.org/10.58935/joas.v1i2.14","url":null,"abstract":"The oral cavity is the mirror of systemic health. Anemia is one such condition, which manifests itself in the oral cavity. According to the World Health Organization, the normal haemoglobin level for an adult male is around 13.8 g/dl and for an adult woman is around 12.1 g/dl. Anemia is defined as when the haemoglobin level in the blood is below the lower extreme of the normal range for the age and sex of the individual. Iron deficiency anaemia is the most common nutritional deficiency disorder in children and women and is worldwide in distribution. It is characterised by fatigue, weakness, pallor, and koilonychias. Thus, oral physicians play an important role in diagnosis and thereby prevention of anemia, as oral manifestations may be the earliest feature of the condition.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82690550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-23DOI: 10.30799/jacs.244.22080201
M. Bhat, F. Khan, Harish Chand Kataria
Cancer is a type of disease of uncontrolled growth cells. The currently available treatments are radiotherapy, chemotherapy, hormone therapy and surgery, in which all of them have side effects. Due to the adverse side effects, it is challenging to develop new drug for cancer treatment. Hence, the scientists are trying to seek the compounds from natural sources to treat cancer. Therefore, in this present investigation, root and leaf extracts of Jurinea dolomiaea Boiss has subjected to evaluate its anti-proliferative effect along with molecular signaling of apoptosis in Ehrlich ascites carcinoma (EAC) cell line. Jurinea dolomiaea root and leaf extracts exhibit a considerable scavenging activity in comparison to a standard antioxidant BHT. Moreover, root and leaf extracts were able to agglutinate 2% RBC of goat blood at minimum 12.5 g/mL and 50.0 g/mL concentration respectively. Cytotoxic activity was also found in root and leaf extract. In haemocytometic observation, the root and leaf extract exhibit about 62.54±2.41% and 53.96±2.34% cell growth inhibition respectively where as standard anticancer drug Bleomycin showed 79.43±1.92% growth inhibition. Morphological change under fluorescence microscope showed nuclear condensation and fragmentation which are the sign of apoptosis. Therefore, current results depict root extract of Jurinea dolomiaea Boiss have anti-proliferative activity against EAC cell line and can be a good source of anticancer agents to treat cancer.
{"title":"In-vivo Anticancer Activity of Root and Leaf extract of Jurinea dolomiaea Boiss (Asteraceae) against Ehrlichs Ascites Carcinoma (EAC) Cell Line","authors":"M. Bhat, F. Khan, Harish Chand Kataria","doi":"10.30799/jacs.244.22080201","DOIUrl":"https://doi.org/10.30799/jacs.244.22080201","url":null,"abstract":"Cancer is a type of disease of uncontrolled growth cells. The currently available treatments are radiotherapy, chemotherapy, hormone therapy and surgery, in which all of them have side effects. Due to the adverse side effects, it is challenging to develop new drug for cancer treatment. Hence, the scientists are trying to seek the compounds from natural sources to treat cancer. Therefore, in this present investigation, root and leaf extracts of Jurinea dolomiaea Boiss has subjected to evaluate its anti-proliferative effect along with molecular signaling of apoptosis in Ehrlich ascites carcinoma (EAC) cell line. Jurinea dolomiaea root and leaf extracts exhibit a considerable scavenging activity in comparison to a standard antioxidant BHT. Moreover, root and leaf extracts were able to agglutinate 2% RBC of goat blood at minimum 12.5 g/mL and 50.0 g/mL concentration respectively. Cytotoxic activity was also found in root and leaf extract. In haemocytometic observation, the root and leaf extract exhibit about 62.54±2.41% and 53.96±2.34% cell growth inhibition respectively where as standard anticancer drug Bleomycin showed 79.43±1.92% growth inhibition. Morphological change under fluorescence microscope showed nuclear condensation and fragmentation which are the sign of apoptosis. Therefore, current results depict root extract of Jurinea dolomiaea Boiss have anti-proliferative activity against EAC cell line and can be a good source of anticancer agents to treat cancer.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82641251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Hiroj Bagde, Dr. Sudhir Dole, Dr. Ashwini Dhop
The oral cavity gives the impression of being an open ecosystem, with a dynamic equilibrium between the entry of microbes, colonisation methods, and host defences designed to remove them: the oral mucosa, the gingiva, the gingival crevices, the gingival crevices, the ging Bacteria need to attach themselves to either hard tooth surfaces or epithelial surfaces in order to prevent eradication. Oral caries, periodontal disease, and peri-implantitis are among of the most frequent oral diseases, and the production and growth of oral biofilms, as well as the inside selection of certain microbes, have all been found to be connected with these conditions. The eradication of the biofilm by mechanical means and the use of antibiotic disinfectants or other types of antibiotics as an adjuvant treatment have been the traditional approaches to periodontal care. Ozone, which has the chemical formula O3, is a triatomic molecule that is composed of three atoms of oxygen. The use of ozone in dentistry and medicine has been advised for the treatment of 260 various diseases and conditions. The ozone therapy has proven to be more helpful than the currently available conventional therapeutic modalities. These modalities typically involve a conservative and minimally intrusive approach to dental care. The demonstration of the molecular processes behind ozone's practical functions is of great help to the field of dentistry.
{"title":"OZONE THERAPY AS AN ADJUNCT THERAPY IN DENTISTRY: A REVIEW","authors":"Dr. Hiroj Bagde, Dr. Sudhir Dole, Dr. Ashwini Dhop","doi":"10.58935/joas.v1i1.7","DOIUrl":"https://doi.org/10.58935/joas.v1i1.7","url":null,"abstract":"The oral cavity gives the impression of being an open ecosystem, with a dynamic equilibrium between the entry of microbes, colonisation methods, and host defences designed to remove them: the oral mucosa, the gingiva, the gingival crevices, the gingival crevices, the ging Bacteria need to attach themselves to either hard tooth surfaces or epithelial surfaces in order to prevent eradication. Oral caries, periodontal disease, and peri-implantitis are among of the most frequent oral diseases, and the production and growth of oral biofilms, as well as the inside selection of certain microbes, have all been found to be connected with these conditions. The eradication of the biofilm by mechanical means and the use of antibiotic disinfectants or other types of antibiotics as an adjuvant treatment have been the traditional approaches to periodontal care. Ozone, which has the chemical formula O3, is a triatomic molecule that is composed of three atoms of oxygen. The use of ozone in dentistry and medicine has been advised for the treatment of 260 various diseases and conditions. The ozone therapy has proven to be more helpful than the currently available conventional therapeutic modalities. These modalities typically involve a conservative and minimally intrusive approach to dental care. The demonstration of the molecular processes behind ozone's practical functions is of great help to the field of dentistry.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78705881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Ravi Kiran, Dr. Kishan Kumar Avula, Dr. Nihari
The incidence of chronic kidney disease is increasing and patients receiving renal replacement therapy including hemodialysis, or renal transplantation will comprise an enlarging segment of the dental patient population. Periodontitis has been found to contribute to systemic inflammatory burden which may have significant effects on the medical management of the end stage renal disease patients. Aims: The aim of the study was to assess the periodontal status of patients receiving hemodialysis from Krishna District Andhra Pradesh. Methods: A cross-sectional study of 200 subjects, 100 subjects each in dialysis, and healthy group was conducted. Periodontal examination included simplified oral hygiene index, probing depth, clinical attachment loss and periodontal screening and recording index, are evaluated in both the groups. Results: In the present study, the periodontal parameters were elevated in the dialysis group as compared to the control group and the results were statistically significant. Investigation of the impact of duration of dialysis on the periodontal tissues of patients with CRF showed that higher levels of clinical parameters in the group of patients undergoing dialysis for more than one year but without any significant difference with group of patients on dialysis duration of less than one year. Conclusions: The results of the present study demonstrate significant association between the prevalence of severe periodontitis in hemodialysis patients compared to healthy individuals because of the negligence of oral hygiene.
{"title":"PERIODONTAL HEALTH STATUS OF CHRONIC RENAL FAILURE PATIENTS IN KRISHNA DISTRICT, ANDHRA PRADESH","authors":"Dr. Ravi Kiran, Dr. Kishan Kumar Avula, Dr. Nihari","doi":"10.58935/joas.v1i1.8","DOIUrl":"https://doi.org/10.58935/joas.v1i1.8","url":null,"abstract":"The incidence of chronic kidney disease is increasing and patients receiving renal replacement therapy including hemodialysis, or renal transplantation will comprise an enlarging segment of the dental patient population. Periodontitis has been found to contribute to systemic inflammatory burden which may have significant effects on the medical management of the end stage renal disease patients. \u0000Aims: The aim of the study was to assess the periodontal status of patients receiving hemodialysis from Krishna District Andhra Pradesh. \u0000Methods: A cross-sectional study of 200 subjects, 100 subjects each in dialysis, and healthy group was conducted. Periodontal examination included simplified oral hygiene index, probing depth, clinical attachment loss and periodontal screening and recording index, are evaluated in both the groups. \u0000Results: In the present study, the periodontal parameters were elevated in the dialysis group as compared to the control group and the results were statistically significant. Investigation of the impact of duration of dialysis on the periodontal tissues of patients with CRF showed that higher levels of clinical parameters in the group of patients undergoing dialysis for more than one year but without any significant difference with group of patients on dialysis duration of less than one year. \u0000Conclusions: The results of the present study demonstrate significant association between the prevalence of severe periodontitis in hemodialysis patients compared to healthy individuals because of the negligence of oral hygiene.","PeriodicalId":14902,"journal":{"name":"Journal of Advanced Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76930760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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