Journal of Allergy and Clinical Immunology最新文献

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A clinically validated assay for rapid determination of type I and type II interferon activity in systemic inflammatory diseases 临床验证的快速测定I型和II型干扰素活性在全身性炎症性疾病

IF 14.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-03 DOI: 10.1016/j.jaci.2026.01.021

Michael T. Lam, Amrita Basu, Kailey E. Brodeur, Courtney LeSon, Evan Hsu, Musaab A. Alhezam, Rachel Weng, Seigo Okada, Casey A. Rimland, Jian Yue, Xiao P. Peng, Christian Wysocki, Anusha Ramanathan, Zhengping Huang, Milena M. Andzelm, Connie L. Jiang, Holly Wobma, Joyce C. Chang, Janet Chou, Mary Beth F. Son, Craig D. Platt, Lauren A. Henderson, Roshini S. Abraham, Pui Y. Lee

引用次数: 0

Efferocytosis Deficiency Exacerbates Local Inflammation and Predicts Recurrence in Chronic Rhinosinusitis with Nasal Polyps 慢性鼻窦炎伴鼻息肉患者efferocylosis缺乏症加重局部炎症并预测复发

IF 14.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-03 DOI: 10.1016/j.jaci.2025.12.1016

Shuang Liang, Bing Yan, Shen Shen, Ying Li, Luo Zhang, Chengshuo Wang

引用次数: 0

Microbial influences on chronic rhinosinusitis 微生物对慢性鼻窦炎的影响

IF 14.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-03 DOI: 10.1016/j.jaci.2026.01.019

Barbara M. Bröker, Claus Bachert

引用次数: 0

Longitudinal T- and B-cell recall response after vaccination with Pfizer-BioNTech mRNA vaccine BNT162b2 接种辉瑞- biontech mRNA疫苗BNT162b2后的纵向T细胞和B细胞回忆反应。

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-01 DOI: 10.1016/j.jaci.2025.10.001

Youmna El-Orfali MSc , Rana Mansour PhD , Habib Al-Kalamouni MSc , Ziad Jabbour BSc , Antoine Abou Fayad PhD , Esber Saba PhD , Ghada Khawaja PhD , Michel J. Massaad PhD

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic that resulted in the death of millions. The Pfizer-BioNTech mRNA vaccine against SARS-CoV-2 (BNT162b2) induced the development of antigen-specific T and B cells, which correlated with protection from disease. However, their ability to mount a true recall response after reactivation was not addressed.

Objective

We determined the longevity, intensity, and phenotype of the T- and B-cell recall responses after vaccination with BNT162b2.

Methods

Twelve participants vaccinated with BNT162b2 were included in this study. Six blood samples were collected before administering the primary dose, at 21 days after the primary dose, and at 1, 3, 6, and 9 months after the booster dose. Antigen-specific B and T cells were stimulated ex vivo, and their abundance, longevity, phenotype, and intensity of their recall responses were analyzed. Plasma and supernatant of activated B cells were used to determine the levels, kinetics, and neutralization potential of antigen-specific immunoglobulins.

Results

Vaccination with BNT162b2 resulted in the development of long-lasting neutralizing immunoglobulins, as well as antigen-specific memory CD4⁺ T cells that proliferate on reactivation, promote a protective T_H1 response, and induce IgG/IgA class switching in antigen-specific memory B cells, which are primed to secrete neutralizing antibodies on reactivation. Additionally, antigen-specific memory CD8⁺ T cells proliferate on reactivation and upregulate granzyme and perforin to eliminate infected cells.

Conclusion

Vaccination with BNT162b2 induces spike-specific memory T and B cells that are reactivated on antigen exposure to mount a recall response that protects from SARS-CoV-2 infection for up to 9 months after immunization.

sars - cov -2引发了一场大流行，导致数百万患者死亡。针对SARS-CoV-2 （BNT162b2）的辉瑞- biontech mRNA疫苗诱导抗原特异性T细胞和B细胞的发育，这与疾病保护相关。然而，他们在重新激活后建立真实回忆反应的能力并没有得到解决。目的确定接种BNT162b2疫苗后T细胞和B细胞召回反应的持续时间、强度和表型。方法12例接种了BNT162b2疫苗的受试者纳入本研究。在给予初始剂量前、初始剂量后21天以及加强剂量后1、3、6和9个月采集6份血液样本。在体外刺激抗原特异性B细胞和T细胞，分析它们的丰度、寿命、表型和召回反应的强度。活化B细胞的血浆和上清用于测定抗原特异性免疫球蛋白的水平、动力学和中和电位。结果BNT162b2疫苗接种可产生持久的中和性免疫球蛋白，以及抗原特异性记忆CD4+ T细胞，这些细胞在再激活后增殖，促进保护性Th1反应，并诱导抗原特异性记忆B细胞中的IgG/IgA类转换，这些细胞在再激活后分泌中和抗体。此外，抗原特异性记忆CD8+ T细胞在再激活后增殖并上调颗粒酶和穿孔素以消除感染细胞。结论：接种BNT162b2疫苗可诱导刺突特异性记忆T细胞和B细胞，这些细胞在抗原暴露后被重新激活，从而产生召回反应，在免疫后长达9个月的时间内保护人们免受SARS-CoV-2感染。

{"title":"Longitudinal T- and B-cell recall response after vaccination with Pfizer-BioNTech mRNA vaccine BNT162b2","authors":"Youmna El-Orfali MSc , Rana Mansour PhD , Habib Al-Kalamouni MSc , Ziad Jabbour BSc , Antoine Abou Fayad PhD , Esber Saba PhD , Ghada Khawaja PhD , Michel J. Massaad PhD","doi":"10.1016/j.jaci.2025.10.001","DOIUrl":"10.1016/j.jaci.2025.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic that resulted in the death of millions. The Pfizer-BioNTech mRNA vaccine against SARS-CoV-2 (BNT162b2) induced the development of antigen-specific T and B cells, which correlated with protection from disease. However, their ability to mount a true recall response after reactivation was not addressed.</div></div><div><h3>Objective</h3><div>We determined the longevity, intensity, and phenotype of the T- and B-cell recall responses after vaccination with BNT162b2.</div></div><div><h3>Methods</h3><div>Twelve participants vaccinated with BNT162b2 were included in this study. Six blood samples were collected before administering the primary dose, at 21 days after the primary dose, and at 1, 3, 6, and 9 months after the booster dose. Antigen-specific B and T cells were stimulated <em>ex vivo,</em> and their abundance, longevity, phenotype, and intensity of their recall responses were analyzed. Plasma and supernatant of activated B cells were used to determine the levels, kinetics, and neutralization potential of antigen-specific immunoglobulins.</div></div><div><h3>Results</h3><div>Vaccination with BNT162b2 resulted in the development of long-lasting neutralizing immunoglobulins, as well as antigen-specific memory CD4<sup>+</sup> T cells that proliferate on reactivation, promote a protective T<sub>H</sub>1 response, and induce IgG/IgA class switching in antigen-specific memory B cells, which are primed to secrete neutralizing antibodies on reactivation. Additionally, antigen-specific memory CD8<sup>+</sup> T cells proliferate on reactivation and upregulate granzyme and perforin to eliminate infected cells.</div></div><div><h3>Conclusion</h3><div>Vaccination with BNT162b2 induces spike-specific memory T and B cells that are reactivated on antigen exposure to mount a recall response that protects from SARS-CoV-2 infection for up to 9 months after immunization.</div></div>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"157 2","pages":"Pages 495-505.e7"},"PeriodicalIF":11.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145283469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient early blood eosinophil increases do not affect dupilumab’s long-term efficacy in patients with moderate-to-severe asthma 短暂的早期血嗜酸性粒细胞增加不影响Dupilumab在中重度哮喘患者中的长期疗效。

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-01 DOI: 10.1016/j.jaci.2025.07.037

Ian D. Pavord MD , Njira L. Lugogo MD , Mario Castro MD , Alberto Papi MD , Arnaud Bourdin MD , Michael E. Wechsler MD , Andréanne Côté MD , Kenneth R. Chapman MD , Changming Xia PhD , Mena Soliman MD , Nami Pandit-Abid PharmD , Juby A. Jacob-Nara MD, DHSc , Harry Sacks MD

Background

Transient increases in blood eosinophil count (BEC) have been observed in dupilumab clinical trials but are rarely associated with clinical symptoms.

Objective

We assessed the effect of early increases in BEC on long-term treatment outcomes.

Methods

Patients aged ≥12 years with moderate-to-severe type 2 asthma from the phase 3 QUEST study (NCT02414854; 52 weeks) who enrolled onto the TRAVERSE open-label extension study (NCT02134028; 96 weeks) were stratified by BEC: with or without ≥2-fold BEC increase any time by week 12 of QUEST, or presence or absence of increased BEC any time during QUEST (defined as <500 cells/μL at baseline but ≥500 cells/μL at any time during QUEST). End points included annualized severe exacerbation rate and change from parent study baseline in prebronchodilator forced expiratory volume in 1 second (FEV₁), 5-item Asthma Control Questionnaire, and type 2 inflammatory biomarkers.

Results

A total of 36.6% of dupilumab-treated patients versus 21.7% of placebo-receiving patients experienced a ≥2-fold BEC change by week 12, while 31.3% versus 28.0% experienced increased BEC any time during QUEST. Dupilumab versus placebo reduced annualized severe exacerbation rate, improved prebronchodilator FEV₁ and questionnaire scores, and reduced biomarkers across subgroups at week 52 of QUEST. Improvements were maintained in all subgroups through week 96 of TRAVERSE.

Conclusions

Dupilumab reduced asthma exacerbations and improved lung function and asthma control up to 148 weeks in patients with uncontrolled moderate-to-severe type 2 asthma irrespective of early transient increases in BEC. Overall safety was consistent with the known dupilumab safety profile.

背景：在dupilumab临床试验中观察到血嗜酸性粒细胞计数（BEC）的短暂增加，但很少与临床症状相关。目的探讨早期BEC升高对长期治疗效果的影响。方法纳入TRAVERSE开放标签扩展研究（NCT02134028, 96周）的3期QUEST研究（NCT02414854, 52周）中年龄≥12岁的中重度2型哮喘患者按BEC分层：在QUEST第12周的任何时间BEC增加/不增加≥2倍，或在QUEST期间任何时间BEC增加/不增加（定义为基线<500细胞/μL，但在QUEST期间任何时间点≥500细胞/μL）。终点包括支气管扩张剂前1秒强迫呼气量（FEV1）、5项哮喘控制问卷（ACQ-5）和2型炎症生物标志物的年化加重率（AER）和双亲研究基线（PSBL）变化。结果36.6%的dupilumumab治疗患者和21.7%的安慰剂治疗患者在第12周出现≥2倍的BEC变化，31.3%和28.0%的患者在QUEST期间任何时间出现BEC增加。与安慰剂相比，Dupilumab降低了AER，改善了支气管扩张剂前FEV1和ACQ-5评分，并降低了QUEST第52周各亚组的生物标志物。所有亚组的改善维持到第96周。结论：dupilumab可减少哮喘发作，改善未控制的中重度2型哮喘患者的肺功能和哮喘控制长达148周，与早期短暂性BEC升高无关。总体安全性与已知的dupilumab安全性一致。

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引用次数: 0

Multiomics insights into retinoic acid–mediated regulation of eosinophils in severe asthma 重度哮喘患者视黄酸介导嗜酸性粒细胞调节的多组学研究

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-01 DOI: 10.1016/j.jaci.2025.10.029

Jun Miyata MD, PhD , Keeya Sunata MD, PhD , Hisashi Sasaki MD , Yusuke Kawashima PhD , Yo Otsu MD , Ryuta Onozato MD , Emiko Matsuyama MD , Shinichi Okuzumi MD, PhD , Takao Mochimaru MD, PhD , Katsunori Masaki MD, PhD , Hiroki Kabata MD, PhD , Ryo Konno PhD , Masaki Ishikawa PhD , Yoshinori Hasegawa PhD , Yoshifumi Kimizuka MD, PhD , Makoto Arita PhD , Koichi Fukunaga MD, PhD

Background

Severe asthma is marked by persistent eosinophilic inflammation, but the role of all-trans retinoic acid (ATRA) in eosinophil homeostasis remains unclear.

Objective

This study examined the regulatory role of ATRA in eosinophil function in severe asthma.

Methods

Multiomics analysis (transcriptomics, proteomics, and lipidomics) was conducted on blood eosinophils from healthy participants and patients with severe asthma. The effects of ATRA on eosinophil function were further analyzed by using flow cytometry and quantitative RT-PCR.

Results

Transcriptomic profiling of eosinophils from patients with severe asthma revealed a distinct gene expression signature, with upregulation of the genes GGT5, IL2RA, CCL23, and NOD2 and downregulation of SPRY2 and HIC1. This phenotype was driven by type 2 cytokines (IL-5 and IL-4) and muramyl dipeptide but was counterregulated by ATRA. Proteomic analysis showed increased expression of P-selectin glycoprotein ligand-1 in SA-EOS, which was upregulated by type 2 cytokines and downregulated by ATRA. Lipidomic analysis identified dysregulated 15-lipoxygenase metabolism in SA-EOS, with ATRA selectively inhibiting cysteinyl leukotriene metabolism while sparing the 15-lipoxygenase pathway. Multiomics analysis of eosinophils from ATRA-treated healthy participants revealed specific downregulation of IL1RL1 and IL3RA, reducing responsiveness to IL-33 and IL-3 and distinguishing them from IL-5–induced eosinophils.

Conclusion

These findings highlight the role of ATRA in maintaining eosinophil homeostasis and counterregulating IL-5–driven activation, thus offering insights into potential therapeutic strategies for severe asthma.

重度哮喘以持续的嗜酸性粒细胞炎症为特征，但全反式维甲酸（ATRA）在嗜酸性粒细胞稳态中的作用尚不清楚。目的探讨ATRA对重度哮喘患者嗜酸性粒细胞功能的调节作用。方法采用多组学（转录组学、蛋白质组学和脂质组学）对健康受试者和重度哮喘患者的血嗜酸性粒细胞进行分析。采用流式细胞术和定量RT-PCR分析ATRA对嗜酸性粒细胞功能的影响。结果重度哮喘患者嗜酸性粒细胞的转录组学分析显示，GGT5、IL2RA、CCL23和NOD2基因表达上调，SPRY2和HIC1基因表达下调，具有明显的基因表达特征。这种表型由2型细胞因子（IL-5和IL-4）和muramyl二肽驱动，但被ATRA拮抗。蛋白质组学分析显示，SA-EOS中p -选择素糖蛋白配体1的表达增加，2型细胞因子上调p -选择素糖蛋白配体1，ATRA下调p -选择素糖蛋白配体1的表达。脂质组学分析发现SA-EOS中15-脂氧合酶代谢失调，ATRA选择性抑制半胱氨酸白三烯代谢，同时保留15-脂氧合酶途径。对atra治疗的健康参与者的嗜酸性粒细胞的多组学分析显示，IL1RL1和IL3RA特异性下调，降低了对IL-33和IL-3的反应性，并将它们与il -5诱导的嗜酸性粒细胞区分出来。结论ATRA在维持嗜酸性粒细胞稳态和抑制il -5激活中的作用，为重症哮喘的潜在治疗策略提供了新的思路。

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引用次数: 0

Evaluating Diet and Nutrition-Related Concerns in a Multidisciplinary Clinic for Pediatric Patients with Atopic Dermatitis 评估儿童特应性皮炎患者的多学科临床饮食和营养相关问题

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-01 DOI: 10.1016/j.jaci.2025.12.025

Wendy Elverson RD LDN , Tina Ho MD , Karol Timmons RN MS CPNP , Maya Dayanim , Lynda Schneider MD FAAAAI , Jennifer Lebovidge PhD

引用次数: 0

Meeting Announcement 会议公告

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-01 DOI: 10.1016/S0091-6749(25)02241-9

引用次数: 0

Quantitative Systems Biology Modeling Estimates Extent of Excessive Kallikrein Generation in Hereditary Angioedema Patients 定量系统生物学模型估计遗传性血管性水肿患者钾激肽过量产生的程度

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-01 DOI: 10.1016/j.jaci.2025.12.009

Allen Kaplan MD FAAAAI , Catherine Miller PharmD, MPH , Mrinal Shah PhD , David Maag PhD , James Butler , Jonathan Phillips

引用次数: 0

Response Drivers in Sebetralstat Placebo-controlled Clinical Trials Sebetralstat安慰剂对照临床试验中的反应驱动因素

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology

Pub Date : 2026-02-01 DOI: 10.1016/j.jaci.2025.12.016

Jonathan Bernstein MD FAAAAI , Emel Aygören-Pürsün MD , Danny Cohn MD PhD , Henriette Farkas MD PhD DSc , William Lumry MD FAAAAI , Andrea Zanichelli MD , James Hao PhD , Michael Smith PharmD , Paul Audhya MD , Erik Hansen , Nathan Teuscher , Marc Riedl MD MS

引用次数: 0

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Journal of Allergy and Clinical Immunology

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