Journal of affective disorders最新文献_第10页

Corrigendum to “Subtypes of suicidal ideation among university students - An ecological momentary assessment study” [J. Affect. Disord. 391 (2025) 119865] “大学生自杀意念亚型——一项生态瞬时评估研究”的勘误[J]。影响。[j].地理学报，2015(5):119865。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-17 DOI: 10.1016/j.jad.2026.121173

Ana Portillo-Van Diest , Gemma Vilagut , Laura Ballester , Paula Carrasco , Raquel Falcó , Margalida Gili , Glenn Kiekens , Francisco H. Machancoses , Jose A. Piqueras , Miquel Roca , Tíscar Rodriguez-Jiménez , Jordi Alonso , Philippe Mortier

引用次数: 0

Efficacy of a portable BLT device on sleep and depressive symptoms in major depressive disorder: A double-blind randomized study 便携式BLT设备对重度抑郁症患者睡眠和抑郁症状的疗效：一项双盲随机研究

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-31 DOI: 10.1016/j.jad.2026.121317

Marie de Deus , Lise Robbe , Cédric Baumann , Amandine Luc , Vincent Laprévote , Charlotte Petit , Eve Cosker

Background

Major depressive disorder (MDD) is a leading cause of disability worldwide and is often associated with anxiety and sleep disturbances. About one-third of patients do not achieve adequate response to pharmacological treatments, underscoring the need for adjunctive non-pharmacological therapies. Bright light therapy (BLT) has shown efficacy in MDD, but conventional devices require patients to remain stationary, limiting adherence. Portable BLT devices may improve convenience and daily integration. This study assessed the efficacy of a portable BLT device on mood, anxiety, and sleep over 8 weeks.

Methods

LUMIDEP was a double-blind, placebo-controlled trial. Adults with MDD were randomized to receive active portable BLT or a visually identical placebo. Final analyses included 18 patients (BLT n = 6; placebo n = 12). Patients underwent 30-min daily sessions for 8 weeks while continuing pharmacological treatments. Depressive symptoms were assessed using the Montgomery–Åsberg Depression Rating Scale (MADRS), anxiety with the Hamilton Anxiety Scale (HAM-A), and sleep with the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS).

Results

Baseline PSQI scores were higher in the BLT group. After 8 weeks, PSQI scores improved within the BLT group, while remaining stable in the placebo group, resulting in no significant between-group difference. No significant differences were observed between groups in HAM-A or MADRS.

Conclusions

Portable BLT appeared to improve sleep quality but did not significantly reduce depressive or anxiety symptoms. Interpretation is limited by group differences, treatment heterogeneity, and small sample size. Larger, stratified trials are warranted to clarify the efficacy of portable BLT in MDD.

背景：重度抑郁症（MDD）是世界范围内致残的主要原因，通常与焦虑和睡眠障碍有关。大约三分之一的患者对药物治疗没有达到足够的反应，强调需要辅助的非药物治疗。明亮光疗法（BLT）已显示出对重度抑郁症的疗效，但传统的设备要求患者保持静止，限制了依从性。便携式BLT设备可以提高便利性和日常集成。本研究评估了便携式BLT设备在8 周内对情绪、焦虑和睡眠的影响。方法：LUMIDEP是一项双盲、安慰剂对照试验。成年重度抑郁症患者被随机分为两组，一组接受有效的便携式BLT，另一组接受视觉上相同的安慰剂。最终分析纳入18例患者（BLT组 = 6例；安慰剂组 = 12例）。患者每天30分钟，持续8 周，同时继续药物治疗。抑郁症状采用Montgomery-Åsberg抑郁评定量表（MADRS），焦虑采用Hamilton焦虑量表（HAM-A），睡眠采用匹兹堡睡眠质量指数（PSQI）和Epworth嗜睡量表（ESS）。结果：BLT组PSQI基线评分较高。8 周后，BLT组PSQI评分有所改善，而安慰剂组则保持稳定，组间无显著差异。各组间HAM-A和MADRS无显著差异。结论：便携式BLT似乎改善了睡眠质量，但没有显著减少抑郁或焦虑症状。解释受到组差异、治疗异质性和小样本量的限制。需要更大规模的分层试验来阐明便携式BLT治疗重度抑郁症的疗效。

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引用次数: 0

Secular- and longitudinal trends in mental health among older adults in Norway: The Tromsø Study 2001-2016 挪威老年人心理健康的长期和纵向趋势：2001-2016年特罗姆瑟研究

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-02-02 DOI: 10.1016/j.jad.2026.121325

Elisabeth Dahl Martinsen , Tom Wilsgaard , Bjarne Koster Jacobsen , Anne Høye , Sameline Grimsgaard , Bjørn Heine Strand , Jonas Johansson

Background

Self-reported symptoms of anxiety and depression may help identify at-risk groups and examine mental health trends on the population level. This study examined sex-specific secular- and longitudinal trends in mental health among Norwegian older adults.

Methods

Data from the Tromsø Study (2001, 2007-2008, 2015-2016) were analyzed. Secular trend analyses involved 12,884 individuals aged 60-84 years (19,631 observations). Longitudinal trends analyses included a subset of 8,766 individuals born between 1917-1947. Depression and anxiety symptoms were measured using the HSCL-10. Scores ≥ 1.85 were used to identify cases with mental distress, a predictor for clinically diagnosed mental disorders. Linear mixed regression and multiple imputation were used for analysis.

Results

From 2001 to 2016, age-adjusted proportions of mental distress among participants aged 60-84 years declined (overall: 9.8 % to 6.6 %, women: 13.7 % to 8.9 %, men: 5.0 % to 4.0 %). Secular trends revealed lower average symptom scores in 2016 than in 2001, particularly in anxiety symptoms and among women. The youngest birth cohorts (1942-1947) experienced the largest longitudinal reductions in HSCL-10 scores; -0.08 (95% confidence interval [CI]: -0.11, -0.04) among women, and -0.04 (95% CI: -0.08, -0.01) among men. The largest increase in HSCL-10 score occurred during 2001-2008 among women born 1917-1921 and among men born between 1922-1931.

Conclusion

Mental distress prevalence among older adults declined from 2001 to 2016. Mental health trends appear to be driven by reduced anxiety scores. Women exhibited stronger trends, narrowing sex differences in mental health. Further research is needed to elucidate these trends.

背景：自我报告的焦虑和抑郁症状可能有助于识别高危人群，并在人口水平上检查心理健康趋势。这项研究调查了挪威老年人心理健康的性别特异性长期和纵向趋势。方法：分析特罗姆瑟研究（2001,2007 - 2008,2015 -2016）的数据。长期趋势分析涉及12,884名年龄在60-84岁之间的个体（19,631次观察）。纵向趋势分析包括在1917-1947年间出生的8766个人。抑郁和焦虑症状用HSCL-10进行测量。得分≥1.85用于识别精神困扰病例，这是临床诊断为精神障碍的预测因子。采用线性混合回归和多元插值方法进行分析。结果：从2001年到2016年，60-84岁参与者中年龄调整后的精神困扰比例下降（总体：9.8%至6.6%，女性：13.7%至8.9%，男性：5.0%至4.0%）。长期趋势显示，2016年的平均症状评分低于2001年，尤其是焦虑症状和女性。最年轻的出生队列（1942-1947）在hsl -10评分上经历了最大的纵向下降；女性为-0.08(95%可信区间[CI]: -0.11, -0.04)，男性为-0.04 （95% CI: -0.08, -0.01）。2001-2008年间，1917-1921年出生的女性和1922-1931年出生的男性的hsl -10评分增幅最大。结论：2001 - 2016年，老年人精神困扰患病率呈下降趋势。心理健康趋势似乎是由焦虑得分降低所驱动的。女性表现出更强的趋势，在精神压力方面缩小了性别差异。需要进一步的研究来阐明这些趋势。

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引用次数: 0

Associations of depressive symptoms and antidepressant medication use with physical function among middle-aged adults: Results from the CARDIA Function study 中年人抑郁症状和抗抑郁药物使用与身体功能的关系：来自CARDIA功能研究的结果

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-02-02 DOI: 10.1016/j.jad.2026.121324

Brett T. Burrows , Richard Sloane , Marissa C. Ashner , Carl F. Pieper , Cora E. Lewis , Kelley Pettee Gabriel , Pamela J. Schreiner , Bjoern Hornikel , Kai Zhang , Nathaniel D.M. Jenkins , Angela Sullivan , C. Barrett Bowling

Background and objectives

Depressive symptoms (DS) are associated with lower physical function among older adults, and similar associations have been shown in middle-aged adults. However, studies have overlooked the role of antidepressant medications.

Methods

We conducted a cross-sectional analysis of the Coronary Artery Risk Development in Young Adults (CARDIA) Function study. Analysis included measured physical performance and self-reported function. Elevated DS were defined by the Center of Epidemiological Studies Depression (CESD) as ≥16. Participants were grouped by level of DS (DS-: <16, DS+: ≥16) and antidepressant use (med-: none, med+: any) into one of four categories: DS−/med-, DS−/med+, DS+/med-, and DS+/med+. Multiple linear regression was used to examine associations between DS and antidepressant use with physical function in middle age.

Results

Participants (n = 2021; 60 ± 4 years, 58.1% female, 44.4% Black race) were categorized to the DS/medication groups as follows: DS-/med-: 73.8%, DS-/med+: 8.3%, DS+/med-: 11.9%, and DS+/med+: 6.0%. Both physical performance and self-reported function scores were highest in the DS-/med- group. Compared to the DS-/med- group (reference), regression coefficients in the fully adjusted model for performance score were -0.73, -0.94, and -0.47 in the DS-/med+, DS+/med-, and DS+/med+ groups, respectively (all p < 0.01, except the DS+/med + group). Compared to the DS−/med- group, regression coefficients in the fully adjusted model for self-reported function score were -1.95, -3.86, and -4.91 in the DS-/med+, DS+/med-, and DS+/med+ groups, respectively (all p < 0.01).

Conclusions

Compared to individuals with low/no DS and no antidepressant medication use all other groups had lower physical performance and self-reported physical function.

背景和目的：抑郁症状（DS）与老年人身体功能低下有关，中年人也有类似的关联。然而，研究忽视了抗抑郁药物的作用。方法：我们对年轻人冠状动脉风险发展（CARDIA）功能研究进行了横断面分析。分析包括测量的身体表现和自我报告的功能。抑郁症流行病学研究中心（CESD）将DS升高定义为≥16。结果：参与者（n = 2021；60 ± 4 岁，58.1%女性，44.4%黑人）分为DS/用药组：DS-/med-: 73.8%, DS-/med+: 8.3%, DS+/med-: 11.9%, DS+/med+: 6.0%。身体表现和自我报告的功能评分在DS-/med组最高。与DS-/med-组（参考）相比，DS-/med+组、DS+/med-组和DS+/med+组的完全调整模型的回归系数分别为-0.73、-0.94和-0.47 （p均为 ）结论：与低/无DS和未使用抗抑郁药物的个体相比，其他组的身体表现和自我报告的身体功能均较低。

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引用次数: 0

The relationship between childhood trauma, inhibitory dysfunction, and emotion processing: Exploring differences across social anhedonia levels 童年创伤、抑制性功能障碍和情绪加工之间的关系：探索社会快感缺失水平的差异

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-30 DOI: 10.1016/j.jad.2026.121312

Yi Xie , Ye-qian Li , Yan-yu Wang , Yi Wang , Raymond C.K. Chan

Background

Childhood trauma (CT) has widespread adverse effects on individual's cognitive and emotional problems; however, little is known about the underlying psychological mechanisms. This study aimed to examine the relationship between CT, inhibitory dysfunction, and emotion processing, as well as to explore potential differences in these associations across groups with different levels of social anhedonia.

Methods

We administered a set of self-reported measures to capture CT, pleasure experiences, emotion regulation as well as executive dysfunction to 1622 healthy participants. Partial correlation network and nodal centrality were estimated. The mediation effect of inhibitory dysfunction on the relationships between CT and emotion processing was examined. Furthermore, participants were divided into three groups (i.e., high, middle and low) according to their social anhedonia (SoA) levels, network comparison tests and mediation effect analysis in each group were performed.

Results

Network analysis showed that CT was negatively associated with cognitive reappraisal (CR) and pleasure experiences, and positively associated with expressive suppression. Inhibitory dysfunction significantly mediated the relationship between CT and emotion regulation. Subgroup analysis showed that significant mediation effect of inhibitory dysfunction on the association between CT and CR was only found in low SoA group, but not in middle and high SoA groups.

Conclusions

Our study suggested that inhibitory dysfunction plays an important role between CT and emotion regulation, which is disrupted in individuals with middle to high levels of social anhedonia. These findings highlight the necessity of considering inhibitory function when developing interventions for trauma-related emotional problems.

童年创伤（CT）对个体的认知和情绪问题有广泛的不良影响；然而，人们对其潜在的心理机制知之甚少。本研究旨在探讨CT、抑制性功能障碍和情绪加工之间的关系，并探讨这些关联在不同程度社交快感缺乏群体中的潜在差异。方法对1622名健康受试者进行CT、愉悦体验、情绪调节和执行功能障碍的自我报告测量。估计了部分相关网络和节点中心性。研究抑制功能障碍对CT与情绪加工关系的中介作用。根据被试的社会快感缺乏程度将其分为高、中、低三组，并对每组进行网络比较测试和中介效应分析。结果网络分析显示，CT与认知重评（CR）和愉悦体验呈负相关，与表达抑制呈正相关。抑制功能障碍显著介导了CT与情绪调节的关系。亚组分析显示，抑制功能障碍对CT和CR相关性的中介作用仅在低SoA组中存在，而在中、高SoA组中没有。结论抑制功能障碍在CT与情绪调节之间起重要作用，在中高水平社交快感缺乏个体中，抑制功能障碍被破坏。这些发现强调了在开发创伤相关情绪问题干预措施时考虑抑制功能的必要性。

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引用次数: 0

Significant mediation by sadness and self-injury is observed in associations between county-level cyberbullying victimization and youth suicidality in rural New York State 在纽约州农村地区，悲伤和自伤在县级网络欺凌受害与青少年自杀之间的关联中被观察到显著的中介作用

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-27 DOI: 10.1016/j.jad.2026.121270

Laura E. Jones , Riya Nadkarni , Nicole Krupa

Background

The ubiquity and popularity of social media among youth has led to skyrocketing increases in cyberbullying rates among American teens. National studies show cyberbullying victimization is experienced differently by sex, race, and sexual orientation. While rural youth experience bullying at higher rates than urban teens, few studies have focused on rural victimization.

Methods

We analyzed cross-sectional data from county-level YRBS, years 2016, 2018, 2021 and 2023, performing multivariable logistic regressions to assess adjusted relationships between cyberbullying, conventional school bullying and suicidality. Stratified models were used to test for effect modification by sex and sexual orientation and mediation analysis was performed to assess mediation of the relationships between suicidality and bullying modalities by self-harming or sadness. Indirect associations in significant mediated relationships were assessed for effect modification by sex and sexual orientation.

Results

Bullied rural youth were significantly more likely to consider suicide, with larger associations for cyberbullying in girls, and conventional bullying in boys. Cyberbullying and conventional bullying were significantly associated with suicidality, with 55–63% mediation by self-harming, and 51–56% mediation by persistent sadness. Indirect effects were significantly moderated by sexual orientation, but not by sex.

Conclusions

Self-harming and sadness are significant mediators for suicidality in the presence of bullying modalities. Results suggest need for educational programs focused on bullying and responsible internet use alongside tailored interventions based on sex, sexual orientation, and mental health history. Access to compassionate and appropriate treatment in rural school-based health centers may be a solution.

社交媒体在年轻人中无处不在和流行，导致美国青少年网络欺凌率飙升。全国性的研究表明，网络欺凌的受害者因性别、种族和性取向而不同。虽然农村青少年遭受欺凌的比例高于城市青少年，但很少有研究关注农村的受害情况。方法分析2016年、2018年、2021年和2023年县级青少年校园暴力调查的横截面数据，采用多变量logistic回归评估网络欺凌、传统校园欺凌与自杀之间的关系。采用分层模型检验性别和性取向对自杀行为的影响，并采用中介分析评估自我伤害或悲伤对自杀行为和欺凌行为之间关系的中介作用。在显著中介关系的间接关联中，评估了性别和性取向对效果的影响。结果受欺凌的农村青少年更有可能考虑自杀，女孩更容易发生网络欺凌，男孩更容易发生传统欺凌。网络欺凌和传统欺凌与自杀显著相关，其中55-63%的自我伤害调解，51-56%的持续悲伤调解。间接影响被性取向显著地缓和，而不是被性别缓和。结论自我伤害和悲伤是霸凌模式下自杀行为的重要中介因素。结果表明，有必要开展教育项目，重点关注欺凌和负责任的互联网使用，以及基于性别、性取向和精神健康史的量身定制的干预措施。在农村学校保健中心获得富有同情心和适当的治疗可能是一种解决办法。

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引用次数: 0

Early-life light exposure and mental health and substance use outcomes in adolescence and young adulthood 生命早期光照与青春期和青年期心理健康和物质使用结果。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-31 DOI: 10.1016/j.jad.2026.121321

Tala El Ghoul , Jing Zhang , Dat Thien Tran , Susanne Strohmaier , Magdalena Żebrowska , Jorge E. Chavarro , A. Heather Eliassen , Jaime E. Hart , Olivia I. Okereke , Eva S. Schernhammer

Background

Experimental models suggest that in utero photoperiod influences circadian regulation and systems tied to later-life anxiety, depression, and addiction. Whether in utero photoperiod is associated with mental health and substance use in adolescents and young adults remains unknown.

Methods

10,721 full term born children from the GUTS cohort contributed to these analyses. Total photoperiod was calculated by summing daily light hours across 280 gestational days using each offspring's exact birth date and state. We used multivariable adjusted generalized estimating equations, logistic regression, and linear regression to estimate odds ratios (ORs) and mean differences (MDs) for self-reported mental health and substance use outcomes across quintiles of in utero photoperiod.

Results

We observed no association between in utero photoperiod and mental health outcomes. Marijuana, opioids, stimulants, and alcohol use also did not differ by photoperiod. However, offspring in the top versus bottom photoperiod had lower odds of ever smoking [MV-OR_Q5vsQ1, 0.89; 95% CI: 0.80,0.99; P = 0.08], smoked fewer cigarettes per day [MV-MD_Q5vsQ1, −0,16; 95%CI: −0.29,-0.04; P = 0.02], and showed lower nicotine dependence [MV-MD_Q5vsQ1, −0,46; 95%CI: −0.8,-0.12; P = 0.007]. No sex interactions were observed for mental health; for smoking and marijuana, males had lower odds of use.

Conclusion

In utero photoperiod was not associated with mental health. Greater prenatal light exposure was linked to reduced smoking, but not alcohol or marijuana use, in offspring. Further research should examine cumulative prenatal and postnatal photoperiod effects on these outcomes.

背景：实验模型表明，子宫内的光周期影响与晚年焦虑、抑郁和成瘾相关的昼夜节律调节和系统。子宫内光周期是否与青少年和年轻人的精神健康和药物使用有关尚不清楚。方法：来自GUTS队列的10,721名足月出生的儿童参与了这些分析。总光周期是通过使用每个后代的确切出生日期和状态，将280个妊娠日的每日光照时数相加来计算的。我们使用多变量调整广义估计方程、逻辑回归和线性回归来估计子宫内光周期中自我报告的心理健康和物质使用结果的优势比（ORs）和平均差异（MDs）。结果：我们观察到子宫内光周期与心理健康结果之间没有关联。大麻、阿片类药物、兴奋剂和酒精的使用也没有因光周期而不同。然而，顶光周期与底光周期的后代吸烟的几率较低[MV-ORQ5vsQ1, 0.89；95% ci: 0.80,0.99；P = 0.08]，每天吸烟较少[MV-MDQ5vsQ1， -0,16；95%置信区间:-0.29,-0.04;P = 0.02]，尼古丁依赖性较低[MV-MDQ5vsQ1， -0,46；95%置信区间:-0.8,-0.12;P = 0.007]。没有观察到性行为对心理健康的影响；在吸烟和大麻方面，男性的使用几率较低。结论：子宫内光周期与心理健康无相关性。产前更多的光照与后代吸烟减少有关，但与酒精或大麻使用无关。进一步的研究应该检查累积的产前和产后光周期对这些结果的影响。

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引用次数: 0

Intolerance of uncertainty and depression in children and adolescents: Systematic review and meta-analysis 儿童和青少年对不确定性的不耐受和抑郁：系统回顾和荟萃分析。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-27 DOI: 10.1016/j.jad.2026.121288

Leo Mares , Mathew Fuller

Background

Intolerance of uncertainty (IU) is a development and maintenance factor for depression and anxiety. Previous reviews found that it associated with anxiety in children and adolescents. However, there was insufficient evidence at the time to review its association with depression in this population.

Method

20 studies investigating the relationship between IU and depression in children and adolescents were identified. Random effects meta-analysis was used to aggregate cross-sectional associations, with age, gender, and measure as moderators. A narrative review of longitudinal findings from relevant studies (K = 6) was also conducted.

Results

Meta-analysis of cross-sectional associations found an overall effect size of r = 0.47. There was limited evidence that age or gender moderated the effect, however there was a significant moderating effect of measure. Namely, when including studies using ‘child-friendly’ measures (i.e., developed and normed with children as opposed to adults), the effect size was r = 0.37. Another analysis revealed that the inhibitory IU subscale was more strongly associated with depression than prospective IU. Longitudinal findings suggested that the association between IU and depression persists over time.

Limitations

Studies were limited to those published in English and including general population samples (e.g., typically developing, without significant medical needs).

Conclusions

There is a medium-strong association between IU and depression symptoms in children and adolescents. However, it may be overestimated by the use of IU measures that are not child-friendly. Future research can further extend the evidence-base through careful measure selection, as well as longitudinal and experimental designs.

背景：不确定性不耐受（IU）是抑郁和焦虑的发展和维持因素。先前的评论发现，它与儿童和青少年的焦虑有关。然而，当时没有足够的证据来审查它与抑郁症在这一人群中的关系。方法：对20项调查儿童和青少年IU与抑郁症关系的研究进行分析。随机效应荟萃分析用于汇总横断面关联，年龄、性别和测量作为调节因子。对相关研究的纵向结果（K = 6）也进行了叙述性回顾。结果：横断面关联的荟萃分析发现总体效应大小r = 0.47。有有限的证据表明，年龄或性别调节的影响，但有显著的调节作用的措施。也就是说，当包括使用“儿童友好”措施的研究时（即，与儿童而不是成人一起开发和规范的研究），效应量为r = 0.37。另一项分析显示，抑制性IU亚量表与抑郁的关联比前瞻性IU更强。纵向研究结果表明，IU和抑郁症之间的关联持续存在。局限性：研究仅限于用英文发表的研究，并包括一般人口样本（例如，通常是发展中国家，没有重大医疗需求）。结论：在儿童和青少年中，IU与抑郁症状之间存在中等强度的关联。然而，使用对儿童不友好的国际单位测量可能会高估。未来的研究可以通过谨慎的测量选择，以及纵向和实验设计来进一步扩展证据基础。

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引用次数: 0

Psychological and mental states mediated the association between physical activity and self-rated health of Chinese centenarians 心理和精神状态在体力活动与百岁老人自评健康的关系中起中介作用

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-26 DOI: 10.1016/j.jad.2026.121254

Songmei Han , Dongxu Zhao , Jiacai Lin , Bo Li , Jinwen Tian , Yali Zhao , Fei Hua , Yunqi Li , Yan Nie , Shihui Fu

Objective

Based on the China Hainan Centenarian Cohort Study, the world's largest and most up-to-date database of the centenarians, this study aimed to explore the association between activity of daily living (ADL) and self-rated health (SRH) and analyze the mediators that affect the interaction between these two factors. This study will reveal health status and provide study basis in the centenarians so as to achieve better health guidance and medical services for older population.

Methods

A total of 992 centenarians were included in this study with questionnaire survey, physical examination, and biological test.

Results

Gender, body mass index, low density lipoprotein cholesterol, and mini-mental state examination (MMSE) had positive correlations with ADL and SRH, while fasting blood glucose and geriatrician depression scale (GDS)-15 had negative correlations with ADL and SRH (all P < 0.05). The total association between ADL and SRH was 0.2500 [95% confidence interval (CI): 0.1960–0.3039], the direct association was 0.1437 (95% CI: 0.0885–0.1989), and the total indirect association was 0.1063 (95% CI: 0.0807–0.1347; all P < 0.001). GDS-15 and MMSE were mediating factors of ADL and SRH, with mediating associations of 0.0636 (95% CI: 0.0430–0.0866) and 0.0326 (95% CI: 0.0182–0.0479), respectively.

Conclusions

ADL was directly associated with SRH and indirectly associated with SRH mediated by psychological and mental states in the centenarians. Therefore, if older population want to become healthy centenarians, they should not only focus on maintaining and improving physical activity, but also could not ignore the role of psychological and mental states.

目的基于世界上最大、最新的中国海南百岁老人队列研究数据库，探讨日常生活活动（activity of daily living， ADL）与自评健康（self-rated health， SRH）之间的关系，并分析影响两者交互作用的中介因素。本研究将揭示百岁老人的健康状况，为更好地为老年人群提供健康指导和医疗服务提供研究依据。方法对992名百岁老人进行问卷调查、体格检查和生物学检查。结果性别、体重指数、低密度脂蛋白胆固醇、精神状态检查量表（MMSE）与ADL、SRH呈正相关，空腹血糖、老年抑郁量表(GDS)-15与ADL、SRH呈负相关（P < 0.05）。ADL与SRH的总相关性为0.2500[95%可信区间（CI）： 0.1960 ~ 0.3039]，直接相关性为0.1437 (95% CI: 0.0885 ~ 0.1989)，间接相关性为0.1063 （95% CI: 0.0807 ~ 0.1347， P均为0.001）。GDS-15和MMSE是ADL和SRH的中介因子，中介相关性分别为0.0636 （95% CI: 0.0430 ~ 0.0866）和0.0326 （95% CI: 0.0182 ~ 0.0479）。结论sadl与百岁老人SRH直接相关，并与心理、精神状态介导的SRH间接相关。因此，老年人要想成为健康的百岁老人，不仅要注重保持和提高体力活动，更不能忽视心理和精神状态的作用。

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引用次数: 0

Adverse events related to buspirone: a real-world pharmacovigilance study using the FAERS database 与丁螺环酮相关的不良事件：使用FAERS数据库的真实世界药物警戒研究。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders

Pub Date : 2026-05-15 Epub Date: 2026-01-31 DOI: 10.1016/j.jad.2026.121240

Zujun Wen , Xiang Liu , Pei Guo , Chen Wang , Xingxing Xu , Peng Liu

Buspirone, a widely used anxiolytic, has incompletely characterized adverse effects. This study aimed to comprehensively characterize buspirone's safety profile by a large-scale analysis of real-world data from the Food and Drug Administration Adverse Event Reporting System (FAERS) database, covering Q1 2006 to Q1 2025. We collected 1744 buspirone-related adverse event reports and analyzed them utilizing various signal detection techniques, including proportional reporting ratio (PRR), reporting odds ratio (ROR), multi-item gamma Poisson shrinker (MGPS), and Bayesian confidence propagation neural network (BCPNN). The most common adverse events were categorized into nervous system disorders and psychiatric disorders, with “dizziness” (n = 141), “anxiety” (n = 133), “drug interaction” (n = 86), “serotonin syndrome” (n = 83), and “tremor” (n = 71) being the most frequently reported. Notably, several safety issues linked to suicide exhibited considerable signals. In addition to the adverse events already listed on the package insert, our research identified unanticipated adverse events associated with improper buspirone use, including “drug abuse” (n = 43), “intentional overdose” (n = 30), and “drug level increased” (n = 17). These findings indicated a potential risk of abuse with buspirone exposure during therapeutic use. Moreover, the study detected a relatively rare but noteworthy signal associated with abnormal body weight, such as “obesity” (n = 19), which merits further attention. The median time to onset for adverse events was 10 days (IQR:16). In conclusion, this pharmacovigilance research underscored the safety hazards related to prolonged buspirone usage, confirmed known risks and identified novel safety signals. These findings enriched the awareness of buspirone's safety profile and provided evidence-based guidance in clinical settings.

丁螺环酮是一种广泛使用的抗焦虑药，其不良反应尚未完全确定。本研究旨在通过对美国食品和药物管理局不良事件报告系统（FAERS）数据库中涵盖2006年第一季度至2025年第一季度的真实数据进行大规模分析，全面表征丁螺环酮的安全性。我们收集了1744份与丁螺环酮相关的不良事件报告，并利用各种信号检测技术进行分析，包括比例报告比（PRR）、报告优势比（ROR）、多项目伽玛泊松收缩率（MGPS）和贝叶斯置信传播神经网络（BCPNN）。最常见的不良事件是分为神经系统疾病和精神疾病,与“眩晕”(n = 141),“焦虑”(n = 133),“药物相互作用”(n = 86),“5 -羟色胺综合征”(n = 83),和“地震”(n = 71)是最常报道。值得注意的是，几个与自杀有关的安全问题显示出相当大的信号。除了包装说明书上已经列出的不良事件外，我们的研究还发现了与丁螺环酮使用不当相关的意外不良事件，包括“药物滥用”（ = 43）、“故意过量”（ = 30）和“药物水平增加”（ = 17）。这些发现表明在治疗使用期间暴露于丁螺环酮有滥用的潜在风险。此外，本研究还发现了一个相对罕见但值得注意的与体重异常相关的信号，如“肥胖”（n = 19），值得进一步关注。不良事件发生的中位时间为10 天（IQR:16）。总之，这项药物警戒研究强调了与长期使用丁螺环酮相关的安全危害，确认了已知的风险，并确定了新的安全信号。这些发现丰富了对丁螺环酮安全性的认识，并为临床环境提供了循证指导。

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