Covid-19 was considered as a global health-related challenge within the past years which affect individual’s quality of life in several aspects. It has been suggested that health status including nutritional status, can be one of the most crucial indicators for Covid-19 infection. It seems that poor dietary pattern background and nutritional deficiencies may increase the risk of covid-19 infection. The purpose of this case-report, was to evaluate the relation between dietary pattern and nutritional status with Covid-19 possibility in 64 years old women infected with Covid-19. Before the study, all the health-related indicators were assessed. The results from this study have indicated that previous nutritional status can be a possible cause for immune system weakness and dysfunction, which may be considered as a leading cause of Covid-19 infection. Planning and recruiting nutritional strategies including high quality diet with variety of food groups can provide nutritional requirements. Moreover, supplementation can prescribe according to patients’ nutritional deficiencies.
{"title":"The Relation Between Dietary Pattern and Nutritional Status with Chronic Diseases and Covid-19- A Case Report","authors":"","doi":"10.33140/ijdmd.07.02.07","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.07","url":null,"abstract":"Covid-19 was considered as a global health-related challenge within the past years which affect individual’s quality of life in several aspects. It has been suggested that health status including nutritional status, can be one of the most crucial indicators for Covid-19 infection. It seems that poor dietary pattern background and nutritional deficiencies may increase the risk of covid-19 infection. The purpose of this case-report, was to evaluate the relation between dietary pattern and nutritional status with Covid-19 possibility in 64 years old women infected with Covid-19. Before the study, all the health-related indicators were assessed. The results from this study have indicated that previous nutritional status can be a possible cause for immune system weakness and dysfunction, which may be considered as a leading cause of Covid-19 infection. Planning and recruiting nutritional strategies including high quality diet with variety of food groups can provide nutritional requirements. Moreover, supplementation can prescribe according to patients’ nutritional deficiencies.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132549223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Epigallocatechin-3-gallate (EGCG) is a fundamental polyphenol compound present in green tea. Green tea has been credited for centuries with providing significant health benefits. The aim of this study was to test whether the antioxidant component of EGCG can enhance hepatic antioxidant enzyme activity and consequently increase endogenous antioxidant defense in mice exposed to cardiovascular disease. Groups of male mice were subjected to different diet (standard fat diet, high fat diet and low-fat diet), exercise (voluntary, chronic and sedentary lifestyle) and EGCG supplementation. EGCG powder was dissolved in 4 ml of drinking water to deliver a daily dose of 30 mg/kg.Mice were anesthetized with isoflurane (Abbott, Cham, Switzerland) 2% (v/v) in a 20% O2 and 80% air mixture by inhalation in a closed container, then euthanized by manual cervical dislocation and were put on the animal's bed to collect liver tissue for analysis of antioxidant enzyme activities.We compared the variation in antioxidant enzyme activity between the control and treated groups using one-way analysis of variance (ANOVA) for𝑝-value ˂ 0.05% was considered statistically significant. Results: In this study we showed that mice on a high-fat diet and sedentary lifestyle had significantly decreased superoxide dismutase 1 (p-value = 0, 001 after diets treatment, p-value = 0, 009 after exercise treatment), glutathion peroxidase 1 (p- value = 0, 016 after diets treatment, p-value = 0, 0022 after exercise treatment), catalase (p- value = 0, 019 after diets treatment,p-value = 0,005 after exercise treatment) and thioredoxin reductase 1(p- value = 0,000 after diets treatment, p-value = 0,027 after exercise treatment) activities. EGCG enhanced the activity of antioxidant enzymes in mice subjected to high fat diet or subjected to sedentary lifestyle.
{"title":"Enhancing Effect of Epigallocatechin-3-Gallate (EGCG) on Liver Antioxidant Activity in Mice Exposed to Cardiovascular Disease Risk","authors":"","doi":"10.33140/ijdmd.07.02.03","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.03","url":null,"abstract":"Objective: Epigallocatechin-3-gallate (EGCG) is a fundamental polyphenol compound present in green tea. Green tea has been credited for centuries with providing significant health benefits. The aim of this study was to test whether the antioxidant component of EGCG can enhance hepatic antioxidant enzyme activity and consequently increase endogenous antioxidant defense in mice exposed to cardiovascular disease. Groups of male mice were subjected to different diet (standard fat diet, high fat diet and low-fat diet), exercise (voluntary, chronic and sedentary lifestyle) and EGCG supplementation. EGCG powder was dissolved in 4 ml of drinking water to deliver a daily dose of 30 mg/kg.Mice were anesthetized with isoflurane (Abbott, Cham, Switzerland) 2% (v/v) in a 20% O2 and 80% air mixture by inhalation in a closed container, then euthanized by manual cervical dislocation and were put on the animal's bed to collect liver tissue for analysis of antioxidant enzyme activities.We compared the variation in antioxidant enzyme activity between the control and treated groups using one-way analysis of variance (ANOVA) for𝑝-value ˂ 0.05% was considered statistically significant. Results: In this study we showed that mice on a high-fat diet and sedentary lifestyle had significantly decreased superoxide dismutase 1 (p-value = 0, 001 after diets treatment, p-value = 0, 009 after exercise treatment), glutathion peroxidase 1 (p- value = 0, 016 after diets treatment, p-value = 0, 0022 after exercise treatment), catalase (p- value = 0, 019 after diets treatment,p-value = 0,005 after exercise treatment) and thioredoxin reductase 1(p- value = 0,000 after diets treatment, p-value = 0,027 after exercise treatment) activities. EGCG enhanced the activity of antioxidant enzymes in mice subjected to high fat diet or subjected to sedentary lifestyle.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132694083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cereal and grains have been using as a source of food molecules for centuries. However, the preparation of microbial growth media from a particular cereal and grain for the growth of microorganisms has not been considered. In this study, preparation of microbial growth media for the cultivation of Bacillus subtilis strain st-103 was done using rye pellets. The rye pellets, obtained after the hydrolysis of rye grains were enriched using Bacillus subtilis strain st-103 producer of protein derived by the ecological selection.The cultivation process of Bacillus subtilis strain st-103 was carried out under aerobic conditions in an incubator shaker (ES-20) at 28 ℃ at 250 rpm. The total viable microorganisms are grown on the media were determined according to standard test method for automated colony forming unit (CFU) assay. According to the result of the experiment, the total viable count of Bacillus subtilis strain st-103 was 1.2 X 108 CFU/ml. Based on the result obtained in the course of scientific work suggest the prospects for further steps of the enrichment of rye grain ( pellets) with Bacillus subtilis strain st-103 to produce microbial feed protein.
{"title":"Preparation and Characterization of Microbial Growth Media and its Application for the Production of Microbial Feed Protein","authors":"","doi":"10.33140/ijdmd.07.02.10","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.10","url":null,"abstract":"Cereal and grains have been using as a source of food molecules for centuries. However, the preparation of microbial growth media from a particular cereal and grain for the growth of microorganisms has not been considered. In this study, preparation of microbial growth media for the cultivation of Bacillus subtilis strain st-103 was done using rye pellets. The rye pellets, obtained after the hydrolysis of rye grains were enriched using Bacillus subtilis strain st-103 producer of protein derived by the ecological selection.The cultivation process of Bacillus subtilis strain st-103 was carried out under aerobic conditions in an incubator shaker (ES-20) at 28 ℃ at 250 rpm. The total viable microorganisms are grown on the media were determined according to standard test method for automated colony forming unit (CFU) assay. According to the result of the experiment, the total viable count of Bacillus subtilis strain st-103 was 1.2 X 108 CFU/ml. Based on the result obtained in the course of scientific work suggest the prospects for further steps of the enrichment of rye grain ( pellets) with Bacillus subtilis strain st-103 to produce microbial feed protein.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114539301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity is a state of excessive body fat accumulation due to imbalance between energy input and energy expenditure. The worldwide disease of adiposity is seen in specific lifestyle of individuals which consume greater number of calories day by day than needed. This review of scientific literature assesses several bioactive compounds from different sources they contain that play an important role in the prevention and therapy of obesity. Bioactive compound from marines, plants, animals and dietary sources have shown anti-obesity effect. Some Prebiotics and probiotics also shown ant-obesity effects in obese individuals. Furthermore, this review focuses on various physical activities that reduces the weight gain and maintain the wellbeing of people and non-pharmacological treatments like transcranial direct current stimulation.
{"title":"Health Benefits of Natural Bioactive Compound from Different Sources: Obesity","authors":"","doi":"10.33140/ijdmd.07.02.09","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.09","url":null,"abstract":"Obesity is a state of excessive body fat accumulation due to imbalance between energy input and energy expenditure. The worldwide disease of adiposity is seen in specific lifestyle of individuals which consume greater number of calories day by day than needed. This review of scientific literature assesses several bioactive compounds from different sources they contain that play an important role in the prevention and therapy of obesity. Bioactive compound from marines, plants, animals and dietary sources have shown anti-obesity effect. Some Prebiotics and probiotics also shown ant-obesity effects in obese individuals. Furthermore, this review focuses on various physical activities that reduces the weight gain and maintain the wellbeing of people and non-pharmacological treatments like transcranial direct current stimulation.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"58 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128007034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Diabetic macular edema (DME) is the most common cause of visual impairment in patients with diabetes mellitus. The prevalence of DME globally is around 6.8 % and in Ethiopia range from 5.7% to 11%. Different factors are associated with DME including poor glycemic control, longer duration, hypertension, dyslipidemia. Objective: To determine the prevalence and associated factors of diabetic macular edema among diabetic patients attending University of Gondar (UOG) hospital, tertiary eye care and training center, NW Ethiopia Methods:A hospital based cross-sectional study was conducted from March 2021 to October 2021. Socio-demographic, clinical and laboratory data of patients was gathered. The collected data was entered into epi-data 4.6 version, exported to SPSS version 20 and analyzed. Results: A total of 165 diabetic patients were enrolled with mean age of 54.71 ±13.66 years, 50.9% male, 85.5% urban dwellers, 79.9% type 2 DM,49.7% on oral hypoglycemic agents and the mean duration of diabetes was 7.93 years. Cataract was the commonest ocular morbidity and 42% of patients had at least mild vision impairment. The overall prevalence of DME was 17% and 5.5% of patients had clinically significant macular edema (CSME). The presence of proteinuria was 8.04 times more likely to have DME. Conclusion: The prevalence of DME among our patients was high. The presence of proteinuria was significantly associated with DME. Screening of diabetic patients for sight threatening retinopathy early and appropriate treatment is recommended.
{"title":"Diabetic Macular Edema Among Diabetic Patients at The University of Gondar Tertiary Eye Care and Training Center, North West Ethiopia","authors":"","doi":"10.33140/ijdmd.07.02.02","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.02","url":null,"abstract":"Background: Diabetic macular edema (DME) is the most common cause of visual impairment in patients with diabetes mellitus. The prevalence of DME globally is around 6.8 % and in Ethiopia range from 5.7% to 11%. Different factors are associated with DME including poor glycemic control, longer duration, hypertension, dyslipidemia. Objective: To determine the prevalence and associated factors of diabetic macular edema among diabetic patients attending University of Gondar (UOG) hospital, tertiary eye care and training center, NW Ethiopia Methods:A hospital based cross-sectional study was conducted from March 2021 to October 2021. Socio-demographic, clinical and laboratory data of patients was gathered. The collected data was entered into epi-data 4.6 version, exported to SPSS version 20 and analyzed. Results: A total of 165 diabetic patients were enrolled with mean age of 54.71 ±13.66 years, 50.9% male, 85.5% urban dwellers, 79.9% type 2 DM,49.7% on oral hypoglycemic agents and the mean duration of diabetes was 7.93 years. Cataract was the commonest ocular morbidity and 42% of patients had at least mild vision impairment. The overall prevalence of DME was 17% and 5.5% of patients had clinically significant macular edema (CSME). The presence of proteinuria was 8.04 times more likely to have DME. Conclusion: The prevalence of DME among our patients was high. The presence of proteinuria was significantly associated with DME. Screening of diabetic patients for sight threatening retinopathy early and appropriate treatment is recommended.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114615471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objective: Repetitive Childhood sexual abuse (CSA) often predisposes CPTSD which affects mental and cardiometabolic health. Early vascular aging (EVA) is the hallmark sign of adverse cardiometabolic health. Smartphone-based cardiovascular optical biomarker (COB) instrumentLyfas captures such risk non-invasively. This study aims to examine two EVA-related COBs such as Arterial stiffness index (ASI) and Vascular aging (VA)in CPTSD and CPTSD with CSA in adults. Method: An IoT-enabled platform is created for the study. Interested visitors enroll and take the CPTSD Check List – Civilian type (PCL-C) self-tests and also fill out an online form related to CSA. The cohorts scoring high for PCL-C encompass Case-I (males and females 189 and 188, respectively)while those having a positive history of CSAcompriseCase-II (males and females 11 and 12, respectively). An equal number of control groups are also considered for each case. All the four groups take Lyfas tests and the COBs are captured from their index finger capillaries using the smartphone’s camera sensor, light, and the technique called arterial photoplethysmography. The EVA-COBs are validated against the ultrasound Doppler and then correlated with the PCL-C scores statistically. Results: The study observes (i) higher anxiety levels in both the genders with the mean SD2/SD1 (anxiety biomarker) in males and females (p-values <0.05), (ii) Lyfas ASI and Doppler’s Acceleration index (AI%) are yielding to each other in males and females, respectively, (iii) High VA in both the genders (p-values <0.05), which are >20, (iv) Mean PCL-C scores of 32.06 and 38 in males and females refer to moderately high CPTSD (p-values <0.05) in the population, (v) risk of EVA in females is twice of males. Conclusions:Lyfas is an assistive biomedical application that can screen and monitor mental health-related cardiometabolic health in the vulnerable population.The VA and ASI are two useful biomarkers. Authors also have linked the biological disorders leading to social aberrations in the CPTSD cases with or without the history of CSA and inferred that CSA further deteriorates the natural coping mechanism of CPTSD.
{"title":"Towards Engineering Early Vascular Aging as the Biomarker of Metabolic Dysregulations in Complex Posttraumatic Stress Disorder Due to Childhood Sexual Abuse: A Lyfas Study","authors":"S. Chattopadhyay","doi":"10.33140/ijdmd.07.02.01","DOIUrl":"https://doi.org/10.33140/ijdmd.07.02.01","url":null,"abstract":"Background and Objective: Repetitive Childhood sexual abuse (CSA) often predisposes CPTSD which affects mental and cardiometabolic health. Early vascular aging (EVA) is the hallmark sign of adverse cardiometabolic health. Smartphone-based cardiovascular optical biomarker (COB) instrumentLyfas captures such risk non-invasively. This study aims to examine two EVA-related COBs such as Arterial stiffness index (ASI) and Vascular aging (VA)in CPTSD and CPTSD with CSA in adults. Method: An IoT-enabled platform is created for the study. Interested visitors enroll and take the CPTSD Check List – Civilian type (PCL-C) self-tests and also fill out an online form related to CSA. The cohorts scoring high for PCL-C encompass Case-I (males and females 189 and 188, respectively)while those having a positive history of CSAcompriseCase-II (males and females 11 and 12, respectively). An equal number of control groups are also considered for each case. All the four groups take Lyfas tests and the COBs are captured from their index finger capillaries using the smartphone’s camera sensor, light, and the technique called arterial photoplethysmography. The EVA-COBs are validated against the ultrasound Doppler and then correlated with the PCL-C scores statistically. Results: The study observes (i) higher anxiety levels in both the genders with the mean SD2/SD1 (anxiety biomarker) in males and females (p-values <0.05), (ii) Lyfas ASI and Doppler’s Acceleration index (AI%) are yielding to each other in males and females, respectively, (iii) High VA in both the genders (p-values <0.05), which are >20, (iv) Mean PCL-C scores of 32.06 and 38 in males and females refer to moderately high CPTSD (p-values <0.05) in the population, (v) risk of EVA in females is twice of males. Conclusions:Lyfas is an assistive biomedical application that can screen and monitor mental health-related cardiometabolic health in the vulnerable population.The VA and ASI are two useful biomarkers. Authors also have linked the biological disorders leading to social aberrations in the CPTSD cases with or without the history of CSA and inferred that CSA further deteriorates the natural coping mechanism of CPTSD.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116440809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.1101/2022.06.03.22274963
R. Bhatti, M. Joumaa, B. Bereczky
Background: Obesity has increased rapidly worldwide in last few decades. According to World Obesity Federation 2018, the prevalence of obesity in UAE amongst Emirati aged 18-69 years has been reported as 32.2% vs 38.5% living with obesity vs overweight in men and 41.8% vs 29.3% living with obesity vs overweight in women. There are many myths amongst general public about obesity. Aim: The objective of the study was to address public questions through online forum regarding weight management. Methods: In this cross-sectional observational study qualitative analysis was done. It was conducted quarterly at Mediclinic City and Parkview Hospital in Dubai from August 2020-September 2021. An online zoom meeting was made available to the public. People who wanted to attend the session registered via dedicated email address. A certified dietician, endocrinologist and bariatric surgeon were available to answer peoples questions. Results: 6 online forums have been conducted. 163 (range 10-90) people attended. Three themes were constructed during data analysis. 1- Diet: what is the best diet and about caloric intake. 2- Insulin resistance or hormone imbalance is responsible for weight gain. 3- Misinformation and unrealistic expectations about bariatric surgery. Feedback from audience was: it was interactive, fun and informative session, it is good to know that it is not my fault and I need to get help. Conclusion: Our results show that patients need support throughout their weight management journey. Healthcare professionals need to be more aware of patients perceptions about weight management so that they can be addressed in consultations. We need more online support sessions facilitated by healthcare professionals. Key words: obesity, zoom meeting, weight management
{"title":"Bridging the gap: A qualitative analysis of online public forum with healthcare professionals in bursting myths about weight management.","authors":"R. Bhatti, M. Joumaa, B. Bereczky","doi":"10.1101/2022.06.03.22274963","DOIUrl":"https://doi.org/10.1101/2022.06.03.22274963","url":null,"abstract":"Background: Obesity has increased rapidly worldwide in last few decades. According to World Obesity Federation 2018, the prevalence of obesity in UAE amongst Emirati aged 18-69 years has been reported as 32.2% vs 38.5% living with obesity vs overweight in men and 41.8% vs 29.3% living with obesity vs overweight in women. There are many myths amongst general public about obesity. Aim: The objective of the study was to address public questions through online forum regarding weight management. Methods: In this cross-sectional observational study qualitative analysis was done. It was conducted quarterly at Mediclinic City and Parkview Hospital in Dubai from August 2020-September 2021. An online zoom meeting was made available to the public. People who wanted to attend the session registered via dedicated email address. A certified dietician, endocrinologist and bariatric surgeon were available to answer peoples questions. Results: 6 online forums have been conducted. 163 (range 10-90) people attended. Three themes were constructed during data analysis. 1- Diet: what is the best diet and about caloric intake. 2- Insulin resistance or hormone imbalance is responsible for weight gain. 3- Misinformation and unrealistic expectations about bariatric surgery. Feedback from audience was: it was interactive, fun and informative session, it is good to know that it is not my fault and I need to get help. Conclusion: Our results show that patients need support throughout their weight management journey. Healthcare professionals need to be more aware of patients perceptions about weight management so that they can be addressed in consultations. We need more online support sessions facilitated by healthcare professionals. Key words: obesity, zoom meeting, weight management","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"118 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126973303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polycystic ovary syndrome (PCOS) is a reproductive endocrine and metabolic disorder. To offer new research direction for polycystic ovary syndrome (PCOS), including its pathogenesis and treatment, this research explores the relationship between neopterin (NPT) and polycystic ovary syndrome. 40 cases with PCOS were selected in the reproductive medicine clinics of the Second Affiliated Hospital of Shandong First Medical University as PCOS group from January 2017 to December 2018. 40 cases with normal pregnancy plan were treated as non-PCOS group, whose menstruation is from 25 days to 35 days. We divided the two groups into two subgroups separately according to their body mass index (BMI): the obese one with BMI≥25kg/m2and non-obese one with BMI<25kg/m2 . The expression levels of triglycerides (TG), total cholesterol (TC), fasting insulin (FINS), C-reactive protein (CRP), neutrophil (N), NPT and interleukin-6 (IL-6) in PCOS group were higher than non-PCOS group. CRP, NPT and IL-6 in the obese group were increased than the non-obese group in the pairwise comparison of its subgroups whether in PCOS group or non-PCOS group. In the analysis of linear correlation, NPT was positively correlated with TG, TC, WBC, N, CRP, FINS, IL-6 and TNF-α (P<0.01). Multivariate Stepwise regression analysis found that FINS and IL-6 was the two most important factors. The expression of NPT in PCOS patients was higher than nonPCOS. NPT maybe play a significant role in the development of PCOS
{"title":"Clinical Study On the Relationship Between Neopterin and Polycystic Ovary Syndrome","authors":"Junjie Zhou, M. Yang, Yingxue Liu, You-Lung Song, Ru Lin, Wenjuan Zhang","doi":"10.33140/ijdmd.07.01.12","DOIUrl":"https://doi.org/10.33140/ijdmd.07.01.12","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a reproductive endocrine and metabolic disorder. To offer new research direction for polycystic ovary syndrome (PCOS), including its pathogenesis and treatment, this research explores the relationship between neopterin (NPT) and polycystic ovary syndrome. 40 cases with PCOS were selected in the reproductive medicine clinics of the Second Affiliated Hospital of Shandong First Medical University as PCOS group from January 2017 to December 2018. 40 cases with normal pregnancy plan were treated as non-PCOS group, whose menstruation is from 25 days to 35 days. We divided the two groups into two subgroups separately according to their body mass index (BMI): the obese one with BMI≥25kg/m2and non-obese one with BMI<25kg/m2 . The expression levels of triglycerides (TG), total cholesterol (TC), fasting insulin (FINS), C-reactive protein (CRP), neutrophil (N), NPT and interleukin-6 (IL-6) in PCOS group were higher than non-PCOS group. CRP, NPT and IL-6 in the obese group were increased than the non-obese group in the pairwise comparison of its subgroups whether in PCOS group or non-PCOS group. In the analysis of linear correlation, NPT was positively correlated with TG, TC, WBC, N, CRP, FINS, IL-6 and TNF-α (P<0.01). Multivariate Stepwise regression analysis found that FINS and IL-6 was the two most important factors. The expression of NPT in PCOS patients was higher than nonPCOS. NPT maybe play a significant role in the development of PCOS","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121701660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Healthy eating and safe exercise are known to help with the management, remission, and prevention of type 2 diabetes. Unfortunately, few people are practicing healthy habits, and the prevalence of diabetes is going up. The barriers to overcome include busy lives, resistance to change, feelings of deprivation, unhealthy cultural practices, no referral to certified diabetes care and education specialists, food and medication insecurity, fear of exercise due to the risk of hypoglycemia, and glycemic dysregulation with the wrong choice of exercise. This paper shows that practicing healthy lifestyle habits is the key to improved satiety along with improving most metabolic parameters.
{"title":"Diabetes Patients Can Improve Satiety by Practicing Healthy Lifestyle Habits","authors":"E. Chacko","doi":"10.33140/ijdmd.07.01.05","DOIUrl":"https://doi.org/10.33140/ijdmd.07.01.05","url":null,"abstract":"Healthy eating and safe exercise are known to help with the management, remission, and prevention of type 2 diabetes. Unfortunately, few people are practicing healthy habits, and the prevalence of diabetes is going up. The barriers to overcome include busy lives, resistance to change, feelings of deprivation, unhealthy cultural practices, no referral to certified diabetes care and education specialists, food and medication insecurity, fear of exercise due to the risk of hypoglycemia, and glycemic dysregulation with the wrong choice of exercise. This paper shows that practicing healthy lifestyle habits is the key to improved satiety along with improving most metabolic parameters.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123743264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nephropathy is a chronic complication characterized by increased urinary albumin excretion (proteinuria) or reduced kidney glomerular filtration rate in both forms of diabetic mellitus, type 1 diabetes mellitus and type 1 diabetes mellitus. Diabetic nephropathy is categorized into stages so called microalbuminuria (urinary albumin excretion greater than 20 g/min and less than or equal to 199 g/min) and macroalbuminuria (urinary albumin excretion greater than or equal to 200 g/min). Hyperglycemia, increased blood pressure levels, and genetic predispositions are the main risk factors for the development of diabetic nephropathy. Nephropathy occurs as a result of an interaction between metabolic and hemodynamic factors, which activate diverse pathways that lead to renal damage. Growing evidence highlights the importance of inflammatory mechanisms in the development and progression of diabetic nephropathy. Therefore, investigation into antiinflammatory strategies may offer new approaches of further effect.
{"title":"Risk Factors and Pathogenesis of Diabetic Nephropathy","authors":"","doi":"10.33140/ijdmd.07.01.02","DOIUrl":"https://doi.org/10.33140/ijdmd.07.01.02","url":null,"abstract":"Nephropathy is a chronic complication characterized by increased urinary albumin excretion (proteinuria) or reduced kidney glomerular filtration rate in both forms of diabetic mellitus, type 1 diabetes mellitus and type 1 diabetes mellitus. Diabetic nephropathy is categorized into stages so called microalbuminuria (urinary albumin excretion greater than 20 g/min and less than or equal to 199 g/min) and macroalbuminuria (urinary albumin excretion greater than or equal to 200 g/min). Hyperglycemia, increased blood pressure levels, and genetic predispositions are the main risk factors for the development of diabetic nephropathy. Nephropathy occurs as a result of an interaction between metabolic and hemodynamic factors, which activate diverse pathways that lead to renal damage. Growing evidence highlights the importance of inflammatory mechanisms in the development and progression of diabetic nephropathy. Therefore, investigation into antiinflammatory strategies may offer new approaches of further effect.","PeriodicalId":150671,"journal":{"name":"International Journal of Diabetes & Metabolic Disorders","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116830603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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