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A Study of Healthcare Provided to Diabetic Patients During the Syrian Crisis in Damascus (Health Awareness, Drug Therapy, Therapeutic Follow-up) 叙利亚危机期间大马士革对糖尿病患者的医疗服务研究(健康意识、药物治疗、治疗随访)
Pub Date : 2022-08-04 DOI: 10.33140/ijdmd.07.02.17
Background This study aims to assess the level of health care for patients with diabetes in Damascus during the Syrian crisis by studying the level of health awareness and its relationship to the levels of Hemoglobin A1c, and studying the availability of drug therapy and the quality of treatment follow-up provided for patients. Methods and materials A descriptive cross-sectional study, that used a paper questionnaire filled out by means of a mini interview, the sample was selected from patients with diabetes who were in the outpatient department of Damascus Hospital and the endocrinology clinic at the Martyr Bassam Abboud Medical Center. Results The study included 385 patients (56.6% males and 43.4% females) and 48.05% of the participants were in the age group of 40-60 years. The level of health awareness among patients was good, especially with regard to information about the role of diet and exercise in diabetes, knowledge of interpreting the results of blood sugar tests and methods to prevent hyperglycemia and hypoglycemia attacks. No relationship was found between the high level of health awareness and decreased values of Hemoglobin A1C in the participants. 74.3% of the participants expressed that they do not face difficulties in order to acquire treatment, as they used to get it for free from health centers. The majority of patients checked their blood sugar level continuously and checked the levels of Hemoglobin A1c, kidney function tests, lipids and cholesterol levels periodically. Conclusion The level of health awareness for diabetic patients in Damascus is generally average, and there are no difficulties in securing treatment for the majority of patients, and the therapeutic follow-up of the disease was at a high level, as laboratory tests required for diabetes are carried out periodically and regularly
本研究旨在通过研究健康意识水平及其与糖化血红蛋白水平的关系,研究药物治疗的可获得性以及为患者提供的治疗随访质量,评估叙利亚危机期间大马士革糖尿病患者的医疗保健水平。方法和材料采用描述性横断面研究,采用小型访谈的方式填写纸质问卷,样本来自大马士革医院门诊部和烈士巴萨姆·阿布德医疗中心内分泌科门诊的糖尿病患者。结果共纳入385例患者(男性56.6%,女性43.4%),40 ~ 60岁年龄组占48.05%。患者的健康意识水平很好,特别是关于饮食和运动在糖尿病中的作用的信息,解释血糖测试结果的知识以及预防高血糖和低血糖发作的方法。在参与者中,没有发现高水平的健康意识与血红蛋白A1C值降低之间的关系。74.3%的参与者表示,他们在获得治疗方面没有困难,因为他们过去常常从保健中心免费获得治疗。大多数患者持续检查血糖水平,定期检查血红蛋白A1c、肾功能、血脂和胆固醇水平。结论大马士革糖尿病患者的健康意识水平一般,大多数患者在获得治疗方面没有困难,疾病的治疗随访水平较高,因为定期和定期进行糖尿病所需的实验室检查
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引用次数: 0
Effect of Vitamin D Deficiency on Ace2 And Inflammatory Factors in Patients with Type 2 Diabetes 维生素D缺乏对2型糖尿病患者Ace2及炎症因子的影响
Pub Date : 2022-08-04 DOI: 10.33140/ijdmd.07.02.13
Objective: To analyze the levels and correlation of vitamin D, ACE2, ACE and inflammatory factors in patients with type 2 diabetes,To explore the effect of vitamin D deficiency on ACE2 and inflammatory factors and the mechanism of action on the occurrence and development of diabetes. Methods: Non-diabetic control 87 cases and type 2 diabetes 96 cases,According to the level of serum 25-hydroxyvitamin D, 47 cases of non-diabetic vitamin D normal group and 40 cases of vitamin D deficiency group were divided into two groups.52 patients in the normal vitamin D group and 44 patients in the vitamin D deficient group were tested for ACE, ACE2, IL-6, TNF-A and other inflammatory indexes.The correlation and influencing factors of vitamin D and each index were analyzed. Results: The levels of HOMA-IR, ACE, AngII, IL-6 and TNF-a in vitamin D deficient group were significantly higher than those in vitamin D normal group.ACE2 and IL-10 were significantly decreased (P < 0.05);Compared with non-diabetic vitamin D deficiency group, BMI, waist circumference, blood pressure, blood lipids, blood glucose, INS, HOMA-IR, ACE, AngII, IL-6 and TNF-A were significantly increased with the severity of vitamin D deficiency.Insulin resistance was more severe, ACE2 and IL-10 decreased significantly(P < 0.05);Pearson correlation analysis showed that vitamin D in non-diabetic group was negatively correlated with AngII and IL-6, but positively correlated with IL-10 (P < 0.05 or P < 0.01).Vitamin D in diabetic group was positively correlated with ACE2 and IL-10, and negatively correlated with ACE, AngII, IL-6, TNF-A, HOMA-IR and HbA1c (all P < 0.01).Multiple linear regression analysis showed that IL-10 and AngII were the main influencing factors of vitamin D Foundation Item: 2020 Government Funded Clinical Medical Talents Training Program (NO: 2020, 124) deficiency in the Non-Diabetic Group (P < 0.05).33.6% of the total variation of regression equation was explained.In diabetic group, ACE2, IL-6, TNF-A, IL-10 and HOMA-IR were the main influencing factors of vitamin D deficiency (P < 0.05), explaining 55.8% of the total variation of regression equation. Conclusion: Vitamin D deficiency may change the improper regulation of ACE2 and ACE/AngII and the release of inflammatory factors, destroy the autoimmune state of the body, and participate in the occurrence and development of diabetes mellitus. The degree of vitamin D deficiency can aggravate insulin resistance by mediating RAS system and inflammatory factors, and increase the potential pathogenic effect of diabetes.ACE2, ACE/AngII and inflammatory factors can be used as markers of diabetes vitamin D deficiency
目的:分析2型糖尿病患者体内维生素D、ACE2、ACE及炎症因子的水平及相关性,探讨维生素D缺乏对ACE2及炎症因子的影响及其在糖尿病发生发展中的作用机制。方法:非糖尿病对照87例,2型糖尿病对照96例,根据血清25-羟基维生素D水平将47例非糖尿病维生素D正常组和40例维生素D缺乏组分为两组。对维生素D正常组52例,维生素D缺乏组44例进行ACE、ACE2、IL-6、TNF-A等炎症指标检测。分析了维生素D与各项指标的相关性及影响因素。结果:维生素D缺乏组HOMA-IR、ACE、AngII、IL-6、TNF-a水平明显高于维生素D正常组。ACE2、IL-10显著降低(P < 0.05);与非糖尿病性维生素D缺乏组相比,BMI、腰围、血压、血脂、血糖、INS、HOMA-IR、ACE、AngII、IL-6、TNF-A随维生素D缺乏严重程度显著升高。胰岛素抵抗更严重,ACE2、IL-10显著降低(P < 0.05);Pearson相关分析显示,非糖尿病组维生素D与AngII、IL-6呈负相关,与IL-10呈正相关(P < 0.05或P < 0.01)。糖尿病组维生素D与ACE2、IL-10呈正相关,与ACE、AngII、IL-6、TNF-A、HOMA-IR、HbA1c呈负相关(P < 0.01)。多元线性回归分析显示,IL-10和AngII是影响非糖尿病组维生素D缺乏的主要因素(P < 0.05),解释了回归方程总变异的33.6%。在糖尿病组中,ACE2、IL-6、TNF-A、IL-10和HOMA-IR是维生素D缺乏的主要影响因素(P < 0.05),占回归方程总变异的55.8%。结论:维生素D缺乏可改变机体ACE2、ACE/AngII的调节不当及炎症因子的释放,破坏机体自身免疫状态,参与糖尿病的发生发展。维生素D缺乏程度可通过介导RAS系统和炎症因子加重胰岛素抵抗,增加糖尿病的潜在致病作用。ACE2、ACE/AngII和炎症因子可作为糖尿病维生素D缺乏症的标志物
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引用次数: 0
Predicting Kidney Care Behaviors in Patients with Type 2 Diabetes: An Application of Health Belief Model 健康信念模型在2型糖尿病患者肾脏护理行为预测中的应用
Pub Date : 2022-08-04 DOI: 10.33140/ijdmd.07.02.14
Purpose: Kidney failure is one of the most important late complications of diabetes with more than half of people waiting for a kidney transplant are people with diabetes. The purpose of the present study was to predict kidney care behaviors in patients with type 2 diabetes based on Health Belief Model. The purpose of this study, was predict to care of kidney in type 2 diabetes patients based on Health Belief Model (HBM). Methods: In this cross-sectional analytical study, 240 patients with type 2 diabetes were selected by simple random sampling method from health centers in Arak in 2020 and information on kidney care behaviors were collected through a reliable and valid questionnaire based on the Health Belief Model and analyzed using Linear regressions. Results: The mean age of patients was 47.51±7.86 years, the mean FBS was 159.65 ± 55.01 mg / dl and the mean score of patients' performances in kidney care was 30.31± 6.42. Among the constructs of the Health Belief Model, awareness (67.6%), severity (38%), self-efficacy (31.8%) and internal cues to action (16.4%) have the highest predictive power and all of the above structures predicted 49% kidney care behavior. Conclusion: This study showed that increasing the information of patients in the field of recognizing renal complications, emphasizing the role of cues to action and finally, increasing the ability of patients to care for the kidneys and prevent kidney complications should be emphasized in educational programs for patients with diabetes.
目的:肾衰竭是糖尿病最重要的晚期并发症之一,等待肾脏移植的患者中有一半以上是糖尿病患者。本研究的目的是基于健康信念模型预测2型糖尿病患者的肾脏护理行为。本研究的目的是基于健康信念模型(HBM)预测2型糖尿病患者的肾脏护理。方法:本横断面分析研究采用简单随机抽样的方法,选取2020年阿拉克市各卫生中心收治的240例2型糖尿病患者,采用基于健康信念模型的可靠有效问卷收集肾脏护理行为信息,并采用线性回归分析。结果:患者平均年龄为47.51±7.86岁,平均FBS为159.65±55.01 mg / dl,肾脏护理表现平均评分为30.31±6.42。在健康信念模型的构念中,意识(67.6%)、严重程度(38%)、自我效能(31.8%)和内部行动提示(16.4%)的预测力最高,以上构念均预测49%的肾脏护理行为。结论:本研究表明,在糖尿病患者的教育中,应重视增加患者对肾脏并发症的认识,强调提示对行动的作用,最终提高患者对肾脏的护理和预防肾脏并发症的能力。
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引用次数: 1
Anti-Spike Antibody Responses to Covid-19 Vaccine 3 Doses in Health Care Workers Working in Acute Care Hospital in Myanmar 缅甸急症护理医院医护人员抗刺突抗体对新冠病毒疫苗3剂的反应
Pub Date : 2022-08-04 DOI: 10.33140/ijdmd.07.02.21
Background The health care workers are prone to COVID-19 infection as they are working in front line; thus, they are in priority groups for vaccination. This study aimed to assess the level of anti-Spike antibody 2 weeks after 3 doses of COVID-19 vaccine among health care workers (HCW). Methods A cross-sectional descriptive study was conducted in July 2022 among health care workers (HCW) who received COVID-19 vaccine 3 doses. Data were collected by using standardized forms and analysis was done. Results A total of 42 HCW were included; the mean anti-Spike antibody level was 3734.19 U/mL. Female had higher anti-Spike antibody level than male, 4857.67 U/mL and 3427.78 U/mL respectively. HCW with diabetes mellitus had significantly higher anti-Spike antibody level 6740.00 U/mL than those without diabetes mellitus 2884.00 U/mL. Anti-Spike antibody level in smokers (3376.42 U/mL) was lower than that of non-smoker (3845.99 U/mL). HCW with history of COVID-19 infection had higher anti-Spike antibody level (4013.79 U/mL) than that of those without infection (3524.48 U/mL); those with history of COVID-19 infection in fourth wave (The Omicron outbreak; 6 months ago) had higher antibody level (4013.79 U/mL) than that of those with history of infection in third wave only (The Delta outbreak; one year ago) (3524.48 U/mL). HCW who got vaccinated in the afternoon had higher antibody level (4350.77 U/mL) than who got in the morning (2912.07 U/mL). Negative relation was detected between time from last vaccination to anti-Spike protein antibody level though it was not statistically significant. Significant predictors for anti-Spike antibody level on univariable analysis were BMI and presence of diabetes. Conclusions Anti-Spike antibody level was significantly related with BMI and diabetes mellitus; those with high BMI and diabetes mellitus had higher level of antibody. Anti-Spike antibody level was relatively higher in female; non-smokers; those with COVID-19 infection particularly in fourth wave (The Omicron infection); those with shorter duration from last vaccination; and those who got vaccination in the afternoon although it was not significant statistically.
背景医务工作者在一线工作,易发生COVID-19感染;因此,他们是接种疫苗的优先群体。本研究旨在评估医护人员接种3剂COVID-19疫苗后2周的抗spike抗体水平。方法对2022年7月接种COVID-19疫苗3剂的医护人员进行横断面描述性研究。采用标准化表格收集数据并进行分析。结果共纳入42例HCW;平均抗spike抗体水平为3734.19 U/mL。女性抗spike抗体水平高于男性,分别为4857.67 U/mL和3427.78 U/mL。糖尿病HCW的抗spike抗体水平为6740.00 U/mL,明显高于非糖尿病HCW的2884.00 U/mL。吸烟者抗spike抗体水平(3376.42 U/mL)低于非吸烟者(3845.99 U/mL)。有COVID-19感染史的人抗spike抗体水平(4013.79 U/mL)高于无感染史的人(3524.48 U/mL);有第四波COVID-19感染史的人(欧米克隆疫情);6个月前)的抗体水平(4013.79 U/mL)高于仅在第三波(三角洲疫情;(3524.48 U/mL)。下午接种的HCW抗体水平(4350.77 U/mL)高于上午接种的HCW抗体水平(2912.07 U/mL)。最后一次接种时间与抗刺突蛋白抗体水平呈负相关,但无统计学意义。单变量分析中抗spike抗体水平的显著预测因子是BMI和糖尿病的存在。结论抗spike抗体水平与BMI、糖尿病有显著相关性;BMI高和糖尿病患者的抗体水平较高。抗刺突抗体水平女性较高;不吸烟者;COVID-19感染者,特别是第四波(欧米克隆感染);距上次接种疫苗时间较短者;而那些在下午接种疫苗的人虽然这在统计上并不显著。
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引用次数: 0
Cultural Practices Doing Harm to Diabetes Management: A Physician-Patient’s Perspective 文化习俗对糖尿病管理的危害:一个医患视角
Pub Date : 2022-08-04 DOI: 10.33140/ijdmd.07.02.20
In spite of extensive efforts to control diabetes with the help of healthy meals, exercise, and medications, the prevalence of diabetes is on the rise. One factor contributing to this problem is unhealthy cultural habits being practiced in different cultures. This paper lists some of the major cultural habits that need to be changed towards mitigating the global problem of diabetes and other chronic diseases.
尽管在健康饮食、运动和药物治疗的帮助下,人们努力控制糖尿病,但糖尿病的患病率仍在上升。造成这一问题的一个因素是不同文化中存在的不健康的文化习惯。本文列出了一些需要改变的主要文化习惯,以减轻糖尿病和其他慢性疾病的全球问题。
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引用次数: 0
How Different Health-Related Interventions Improve Metabolic Impairments in Individuals with Autism Spectrum Disorder 不同的健康相关干预措施如何改善自闭症谱系障碍患者的代谢障碍
Pub Date : 2022-08-04 DOI: 10.33140/ijdmd.07.02.16
Autism Spectrum Disorder, is a neuro-developmental disorder diagnosed at the age of three. Individuals with ASD may have several health-related challenges including insulin resistance, dyslipidemia, over-weight and other metabolic impairments which may be due to poor nutrition, low quality dietary pattern, food selectivity and low level of physical activity. There are many nutritional and physical activity interventions introduced in autism society. The puspose of this study was to assess and discuss about some nutritional and physical activity interventions which are usually prescribed for individuals with ASD.
自闭症谱系障碍是一种神经发育障碍,在三岁时被诊断出来。患有自闭症谱系障碍的人可能会面临一些与健康相关的挑战,包括胰岛素抵抗、血脂异常、超重和其他代谢障碍,这些障碍可能是由于营养不良、低质量的饮食模式、食物选择性和低水平的身体活动造成的。自闭症社会引入了许多营养和体育活动干预措施。这项研究的目的是评估和讨论一些营养和体育活动干预措施,这些干预措施通常是为自闭症患者开的处方。
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引用次数: 0
The Germinal Triumvirate- Wilm’s Tumour 生发三巨头-威尔姆氏肿瘤
Pub Date : 2022-08-04 DOI: 10.33140/ijdmd.07.02.18
Additionally, designated as nephroblastoma, tri-phasic embryonal Wilma’s tumour is constituted of varying quantities of blastemal, epithelial and stromal components. Besides, biphasic and monophasic neoplasms are frequently discerned. Epithelial and stromal elements may emerge as poorly differentiated to well differentiated components. Morphological assessment of tri-phasic Wilm’s tumour is efficacious and confirmatory. However, appropriate categorization of neoplasms composed of pure blastema, epithelium or stroma can be challenging. Extensive tissue sampling, pertinent immunohistochemistry and molecular techniques are advantageously adopted in discerning cogent diagnostic features.
此外,被称为肾母细胞瘤的三相胚胎性威尔玛瘤由不同数量的胚质、上皮和间质成分组成。此外,双相和单相肿瘤也很常见。上皮和间质成分可能从低分化到高分化。三期Wilm肿瘤的形态学评估是有效的和确定的。然而,由纯胚、上皮或间质组成的肿瘤的适当分类可能具有挑战性。广泛的组织取样,相关的免疫组织化学和分子技术有利于识别有说服力的诊断特征。
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引用次数: 0
Predictive Ann Modelling of Thermorheological Properties of Iron-Oxide Yield Stress Nanofluid 氧化铁屈服应力纳米流体热流变特性的预测人工神经网络建模
Pub Date : 2022-07-26 DOI: 10.33140/ijdmd.07.02.05
Suraj Narayan, Dhar, M. A. Hassan
The intent of the research is to find the dependency of the volume fraction of nanoparticle (φ) and the temperature on the absolute viscosity (μnf) of Fe3O4 nanoparticles in Carbopol polymer gel. Rheological and stability analysis of the solution is identified. A total of 48 viscosity values has been calculated from experiments using two different base fluid concentrations and two different nanofluid concentrations at eight different temperatures. The data gathered are used for the training of an ANN (Artificial Neural Network) to observe results in a predefined range of two input criteria. It uses a feed-forward perceptron ANN with a temperature input, a volume concentration input, and a viscosity output. The topology was established by trial and error, and the two-layer model having ten neurons in the hidden layer that used the tansig function produced the best results. Ten training functions were utilized to analyze the best result for nf prediction, and the trainbr algorithm was found to be the best ANN. Due to the trained ANN, the anticipated value of viscosity is obtained from each temperature and volume concentration combination. The best results were witnessed with trainlm algorithm with an MSE value of 5.92e-4 and a R2 value of 0.9988 for forecasting of viscosity. Nanoparticle volume concentration increases with viscosity, while temperature increases cause viscosity to decrease. As the temperature rises from 15°C to 50°C, the shear stress value drops with a corresponding shear rate. The shear stress value of the associated shear rate decreases as the nanoparticle concentration rises.
研究的目的是寻找纳米颗粒体积分数(φ)和温度对caropol聚合物凝胶中Fe3O4纳米颗粒绝对粘度(μnf)的依赖关系。对溶液进行了流变性和稳定性分析。在8种不同温度下,使用两种不同的基液浓度和两种不同的纳米流体浓度,共计算出48个粘度值。收集到的数据用于训练人工神经网络,在预定义的两个输入标准范围内观察结果。它使用具有温度输入、体积浓度输入和粘度输出的前馈感知器ANN。通过反复试验建立拓扑结构,隐藏层有10个神经元的二层模型使用tansig函数得到了最好的结果。利用10个训练函数对nf预测的最佳结果进行分析,发现trainbr算法是最佳的人工神经网络算法。由于训练好的人工神经网络,粘度期望值由每个温度和体积浓度组合得到。用trainlm算法预测黏度效果最好,MSE值为5.92e-4, R2值为0.9988。纳米颗粒体积浓度随粘度的增加而增加,而温度的升高导致粘度的降低。随着温度从15℃升高到50℃,剪切应力值随相应的剪切速率下降。随着纳米颗粒浓度的升高,相关剪切速率的剪应力值减小。
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引用次数: 0
Effect of Food Additives on The Food Quality and Safety: A Review 食品添加剂对食品质量安全的影响
Pub Date : 2022-07-26 DOI: 10.33140/ijdmd.07.02.06
This paper is aimed to review the effect of food Additives on the food quality and food safety. Food additives are any organic substances that are intentionally or unintentionally added to food in small quantities during production or processing to improve the organoleptic quality (colour, flavour, appearance, taste and texture) of the food. They contain functional classes, such as antioxidants, colorants, emulsifiers, preservatives, stabilizers, sweeteners, and thickeners. They also increase the shelf life of the food by maintaining product consistency. We may have problems with additives, substances deliberately added to foods, to add colour, to make them tastier, to make them sweeter, to make them last longer, or to break down big fat globules into little ones, so that the fat and water do not separate. Some people are sensitive to particular food additives and may have reactions like hives or diarrhoea. It is important to use food additives to improve the quality of a food. Food additive used as Preservative because of they act as antimicrobial and antioxidants used to prevent microbial spoilage. This Preservation is basically done for preserve the natural characteristics of food and preserves the appearance of food and increase the shelf value of food for some long-term storage. Food additives also give the food a smooth and consistent texture example emulsifier prevent liquid products from separating; Improve or preserve the nutrient value; Maintain the wholesomeness of foods; Control the acid-base balance of foods and provide leavening, provide color and enhance flavor. Therefore, Food additives are substances that food manufacturer’s use in small quantity to maintain the quality properties or enhance their colour, flavour and texture at the same time also affects the original quality characterises of food including safety of foods.
本文旨在综述食品添加剂对食品质量和食品安全的影响。食品添加剂是指在生产或加工过程中有意或无意少量添加到食品中的任何有机物质,以改善食品的感官品质(颜色、味道、外观、味道和质地)。它们包含功能类,如抗氧化剂、着色剂、乳化剂、防腐剂、稳定剂、甜味剂和增稠剂。它们还通过保持产品的一致性来延长食品的保质期。我们可能会遇到添加剂的问题,故意添加到食物中的物质,增加颜色,使它们更美味,使它们更甜,使它们更持久,或者把大的脂肪球分解成小的,这样脂肪和水就不会分离。有些人对特定的食品添加剂敏感,可能会出现荨麻疹或腹泻等反应。使用食品添加剂对提高食品质量很重要。用作防腐剂的食品添加剂,因为它们具有抗菌剂和抗氧化剂的作用,用于防止微生物变质。这种保存基本上是为了保存食物的自然特性,保存食物的外观,增加食物的货架价值,以便长期储存。食品添加剂还使食品具有光滑一致的质地,例如乳化剂防止液体产品分离;提高或保持营养价值;保持食物的健康;控制食物的酸碱平衡,提供发酵,提供颜色和增强风味。因此,食品添加剂是食品制造商少量使用以保持食品质量特性或增强其色、味和质地的物质,同时也会影响食品原有的质量特征,包括食品的安全性。
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引用次数: 0
Can Serum Uric Acid Predict Prediabetes in Adult Males? A Case Control Study 血清尿酸能预测成年男性糖尿病前期吗?病例对照研究
Pub Date : 2022-07-26 DOI: 10.33140/ijdmd.07.02.04
It is well known that serum uric acid (SUA) involved in the metabolic dysregulations which leads to the development of type 2 diabetes mellitus (T2DM) but this relation is not fully explored with prediabetes (PreDM) which is a metabolic state characterized by higher than normal glucose level but not enough to be considered as diabetes [1,2]. About two-thirds of those with preDM will progress to T2DM [3]. Those with preDM are almost identical (regarding risk factors) to those with T2DM (advanced age, obesity and diminished physical activity...etc.) and also are predisposed to develop both micro and macrovascular complications of overt T2DM [4]. Accumulation of SUA in excess play key role in the pathogenesis of metabolic syndrome (overweight, elevated blood pressure, dyslipidemia and abnormal glucose metabolism) [5]. The Preventive Cardiology Information System (PreCIS) database assured that for each one mg/dl rise in the SUA level, there was increase in the risk of death by 39% and even after adjusting for other cardiovascular risk factors, the SUA level continued to predict the risk of death [6].
众所周知,血清尿酸(SUA)参与代谢失调,导致2型糖尿病(T2DM)的发生,但与前驱糖尿病(PreDM)的关系尚未充分探讨。前驱糖尿病是一种以高于正常血糖水平为特征的代谢状态,但不足以被认为是糖尿病[1,2]。大约三分之二的糖尿病前期患者会发展为2型糖尿病[3]。在危险因素方面,糖尿病前期患者与T2DM患者几乎相同(高龄、肥胖和体力活动减少等),也容易出现显性T2DM的微血管和大血管并发症[4]。过量SUA的积累在代谢综合征(超重、血压升高、血脂异常、糖代谢异常)的发病机制中起着关键作用[5]。预防心脏病学信息系统(PreCIS)数据库保证,SUA水平每升高1 mg/dl,死亡风险就会增加39%,即使在调整了其他心血管危险因素后,SUA水平仍然可以预测死亡风险[6]。
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引用次数: 0
期刊
International Journal of Diabetes &amp; Metabolic Disorders
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