Pub Date : 2019-02-01DOI: 10.33980/JBCC.2019.V05I01.015
Z. Omar, Shivaji Jadhav, Megha Rai
Proton–ligand association constants of organic ligand N-[(E)-(2-Nitrophenyl) methylen]isonicotinohydrazid with Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) metal ions have been studied by pH-metric technique at 27±1Cͦ in 70%(v/v) ethanol – water medium at 1M (NaClO4) ionic strength. Organic ligand was synthesized by condensation of equimolar mixture of Anti-mycobacterial agent with aromatic aldehyde. The reaction progress and purity of organic ligands were confirmed by thin layer chromatography. Formation of organic ligands was confirmed with the help of MP, IR, H NMR, C NMR and elemental analysis. The stability constants of these binary complexes were evaluated and order of stability constant found as Zn (II) >Ni (II) > Cu (II) > Mn (II) > Co (II).
采用pH-metric技术研究了有机配体N-[(E)-(2-硝基苯基)甲基]异烟肼与Mn (II)、Co (II)、Ni (II)、Cu (II)和Zn (II)金属离子在70%(v/v)乙醇-水介质中、1M (NaClO4)离子强度、27±1C度的质子-配体缔合常数。采用等摩尔抗分枝杆菌剂与芳香醛的缩合反应合成了有机配体。用薄层色谱法确定了反应过程和有机配体的纯度。通过MP、IR、H NMR、C NMR和元素分析证实了有机配体的形成。测定了这些二元配合物的稳定性常数，稳定性常数的顺序为Zn (II) >Ni (II) > Cu (II) > Mn (II) > Co (II)。
{"title":"Determination of Metal-Ligand Stability Constant of Transition Metal Complexes with Pharmacologically Active Ligand N-[(E)-(2- Nitrophenyl)methylen]isonicotinohydrazid","authors":"Z. Omar, Shivaji Jadhav, Megha Rai","doi":"10.33980/JBCC.2019.V05I01.015","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.015","url":null,"abstract":"Proton–ligand association constants of organic ligand N-[(E)-(2-Nitrophenyl) methylen]isonicotinohydrazid with Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) metal ions have been studied by pH-metric technique at 27±1Cͦ in 70%(v/v) ethanol – water medium at 1M (NaClO4) ionic strength. Organic ligand was synthesized by condensation of equimolar mixture of Anti-mycobacterial agent with aromatic aldehyde. The reaction progress and purity of organic ligands were confirmed by thin layer chromatography. Formation of organic ligands was confirmed with the help of MP, IR, H NMR, C NMR and elemental analysis. The stability constants of these binary complexes were evaluated and order of stability constant found as Zn (II) >Ni (II) > Cu (II) > Mn (II) > Co (II).","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86697981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/jbcc.2019.v05i01.025
K. S. Jamwal, Kuldip Singh, M. Thakur
Present research work deals with comprehensive biometrical studies conducted on hymenopteran, especially members of family vespidae viz. Vespa auraria collected from 10 localities, V. tropica from 3 localities, V. basalis from 4 localities, V. orientalis, Polistes hebraeus and Ropalidia ferruginea from one locality respectively sampled from different agroclimatic zones of Himachal Pradesh, situated in the lap of north west Himalayas. Different species were sampled from 14 localities having different altitude and climatic conditions. 59 morphological characters pertaining to mouthparts, antenna, forewing, hindwing, foreleg, hindleg, tergites and sternites were studied. Biometrical data was analysed statistically, using Analysis of variance (ANOVA), Duncan’s Multiple Range test, ttest, correlation and Multivariate Discriminant Analysis.
{"title":"Multivariate Biometrical Studies on Vespa spp. from Himachal Pradesh","authors":"K. S. Jamwal, Kuldip Singh, M. Thakur","doi":"10.33980/jbcc.2019.v05i01.025","DOIUrl":"https://doi.org/10.33980/jbcc.2019.v05i01.025","url":null,"abstract":"Present research work deals with comprehensive biometrical studies conducted on hymenopteran, especially members of family vespidae viz. Vespa auraria collected from 10 localities, V. tropica from 3 localities, V. basalis from 4 localities, V. orientalis, Polistes hebraeus and Ropalidia ferruginea from one locality respectively sampled from different agroclimatic zones of Himachal Pradesh, situated in the lap of north west Himalayas. Different species were sampled from 14 localities having different altitude and climatic conditions. 59 morphological characters pertaining to mouthparts, antenna, forewing, hindwing, foreleg, hindleg, tergites and sternites were studied. Biometrical data was analysed statistically, using Analysis of variance (ANOVA), Duncan’s Multiple Range test, ttest, correlation and Multivariate Discriminant Analysis.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75424451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/JBCC.2019.V05I01.027
P. Tambade, B. Shelke
The synthesis of Schiffs base ligand of 2-hydroxy 1napthaldehyde with glycine in abundantly available water as a solvent is claimed in this paper. For the synthesis of this classical Schiffs base, potassium hydroxide (KOH) is used as a base under ultrasonic conditions. Various reaction parameters were explored to find out optimal reaction conditions viz. effect of solvent, temperature, time, and ultrasound wave. The synthesized ligand was identified by comparing with standard product on TLC and further confirmed by melting point, IR and mass analysis. The ligand is then used for complexation with transition metal (iron) using ultrasound as a facilitator.
{"title":"An Efficient and Green Protocol for the Synthesis of Schiff’s Base Ligand of 2-Hydroxy 1- Napthaldehyde With Glycine in Water and its Complexation with Iron Metal under Sonication","authors":"P. Tambade, B. Shelke","doi":"10.33980/JBCC.2019.V05I01.027","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.027","url":null,"abstract":"The synthesis of Schiffs base ligand of 2-hydroxy 1napthaldehyde with glycine in abundantly available water as a solvent is claimed in this paper. For the synthesis of this classical Schiffs base, potassium hydroxide (KOH) is used as a base under ultrasonic conditions. Various reaction parameters were explored to find out optimal reaction conditions viz. effect of solvent, temperature, time, and ultrasound wave. The synthesized ligand was identified by comparing with standard product on TLC and further confirmed by melting point, IR and mass analysis. The ligand is then used for complexation with transition metal (iron) using ultrasound as a facilitator.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"154 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75766450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/JBCC.2019.V05I01.007
P. Giri
Apart from chavicol, methyl chavicol, camphor and linalool another major compound cineole is typically present in a very high amount in the essential oil of Ocimum americanum growing in different agro climatic region of West Bengal. Conventionally Cineole (1,8 Cineole) is obtained from sufficiently matured Eucalyptus sp. The article deals with the efficiency of the in vitro mass propagation of this species as a strategy of alternative cheaper way of commercial production of the aromatic compounds as a constituent of essential oil.
{"title":"Phytochemical Analysis of Ocimum americanum Linn. with Special Reference to the Impact of In vitro Flowering on the Production of Aromatic Compounds","authors":"P. Giri","doi":"10.33980/JBCC.2019.V05I01.007","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.007","url":null,"abstract":"Apart from chavicol, methyl chavicol, camphor and linalool another major compound cineole is typically present in a very high amount in the essential oil of Ocimum americanum growing in different agro climatic region of West Bengal. Conventionally Cineole (1,8 Cineole) is obtained from sufficiently matured Eucalyptus sp. The article deals with the efficiency of the in vitro mass propagation of this species as a strategy of alternative cheaper way of commercial production of the aromatic compounds as a constituent of essential oil.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73983876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/JBCC.2019.V05I01.026
V. Katoch
Bruchids are seed borers and attack on wild leguminous hosts in field and the edible legumes in stores. All the known beetles of family Bruchidae feed on seeds of 34 families of kingdom Plantae and about 80% of them feed on the seeds belonging to family Fabaceae. Bruchids attacking green pods of wild legumes are usually univoltine, has specific but long developmental period and life span. These are generally referred as field bruchids. Field studies on the biology of Bruchidius albizziae Arora (Coleoptera: Bruchidae) on the pods of Acacia catechu Willd revealed that the heavy seed infestation occurred from early March to second week of April, 2014. The study on biology of B. albizziae on seed pods indicated 7.0±1.49 days oviposition period, 6.5±1.08 days incubation period, larval period 39.7±2.33 days while pupal period was 6.4±1.17 days. The adult longevity for male was 10.9 ± 1.66 days where as for female 12.7 ± 2.49 days. The total developmental period was 48.2 ± 4.15 days. Along with the emergence of adult bruchids, a larval parasitoid, Entedon albiziarum Rasplus (Hymenoptera: Eulophidae: Entedontinae) has also been recorded. This bio-controlling agent plays an important role in the suppression of pest population in the field.
{"title":"Studies on biology of a field bruchid, Bruchidius albizziae (Coleoptera: Bruchidae) infesting seeds of Acacia Catechu Willd","authors":"V. Katoch","doi":"10.33980/JBCC.2019.V05I01.026","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.026","url":null,"abstract":"Bruchids are seed borers and attack on wild leguminous hosts in field and the edible legumes in stores. All the known beetles of family Bruchidae feed on seeds of 34 families of kingdom Plantae and about 80% of them feed on the seeds belonging to family Fabaceae. Bruchids attacking green pods of wild legumes are usually univoltine, has specific but long developmental period and life span. These are generally referred as field bruchids. Field studies on the biology of Bruchidius albizziae Arora (Coleoptera: Bruchidae) on the pods of Acacia catechu Willd revealed that the heavy seed infestation occurred from early March to second week of April, 2014. The study on biology of B. albizziae on seed pods indicated 7.0±1.49 days oviposition period, 6.5±1.08 days incubation period, larval period 39.7±2.33 days while pupal period was 6.4±1.17 days. The adult longevity for male was 10.9 ± 1.66 days where as for female 12.7 ± 2.49 days. The total developmental period was 48.2 ± 4.15 days. Along with the emergence of adult bruchids, a larval parasitoid, Entedon albiziarum Rasplus (Hymenoptera: Eulophidae: Entedontinae) has also been recorded. This bio-controlling agent plays an important role in the suppression of pest population in the field.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85201336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/JBCC.2019.V05I01.006
J. D. Pandey, R. Sethi, S. C. Shrivastava, Vandna Pathak, S. Vishwakarma
Density and ultrasonic speed data have been used to calculate a number of useful and important thermoacoustic and thermodynamic parameters such as thermal expansivities, α, isothermal compressibility, βT, internal pressure, Pint, specific heat ratio, Υ, surface tension, σ, Pseudo-Grüneisen parameter, Г, non-linearity parameter, B/A, by empirical relations at T= (303, 308, 313 and 318) K temperatures in the range concentration from 0.05 to 1 molar. Solvation number, Sn, has been computed to support the conformational change in geometry of aqueous methyl orange solution. The calculated values highly support the change in orientation and abnormal behavior of methyl orange solution at varying concentrations and quite satisfactory results are obtained.
{"title":"Computation of Thermoacoustic and Thermodynamic Properties of Aqueous Methyl Orange Solution from Density and Sonic Speed Data","authors":"J. D. Pandey, R. Sethi, S. C. Shrivastava, Vandna Pathak, S. Vishwakarma","doi":"10.33980/JBCC.2019.V05I01.006","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.006","url":null,"abstract":"Density and ultrasonic speed data have been used to calculate a number of useful and important thermoacoustic and thermodynamic parameters such as thermal expansivities, α, isothermal compressibility, βT, internal pressure, Pint, specific heat ratio, Υ, surface tension, σ, Pseudo-Grüneisen parameter, Г, non-linearity parameter, B/A, by empirical relations at T= (303, 308, 313 and 318) K temperatures in the range concentration from 0.05 to 1 molar. Solvation number, Sn, has been computed to support the conformational change in geometry of aqueous methyl orange solution. The calculated values highly support the change in orientation and abnormal behavior of methyl orange solution at varying concentrations and quite satisfactory results are obtained.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77219255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/jbcc.2019.v05i01.001
V. Priya, P. Sharma, Divya Vishambra
In the present work, thiomer have been synthesized via thiourea reactions in high degree of modification and degree of substitution is 2.1. Preparation of polymer follows green chemistry protocol with respect to green solvent utilization and zero waste generation. The thiol products are responsive for further derivatization and were modified to a sulphide. The above mentioned reactions were also carried out using microwave heating to achieve maximum yet uniform modification of red toon lignin. The extent of the derivatization processes was confirmed by iodine titration and precipitation titration. The prepared material have been characterised by some physical and chemical methods such as analytical determination, FTIR, SEM and EDX analysis. The analytical results supported highest sulphur content of 47.93% in thiomer. Synthesised green thiomers have been explored as arsenic ion sorbent at 60ppm. The result showed maximum sorption efficiency 86-90% for Fe(III) in aqueous system.
{"title":"Synthesis of Innovative Thiolated Red Toon Lignin for the Removal of Fe(III) from Aqueous System","authors":"V. Priya, P. Sharma, Divya Vishambra","doi":"10.33980/jbcc.2019.v05i01.001","DOIUrl":"https://doi.org/10.33980/jbcc.2019.v05i01.001","url":null,"abstract":"In the present work, thiomer have been synthesized via thiourea reactions in high degree of modification and degree of substitution is 2.1. Preparation of polymer follows green chemistry protocol with respect to green solvent utilization and zero waste generation. The thiol products are responsive for further derivatization and were modified to a sulphide. The above mentioned reactions were also carried out using microwave heating to achieve maximum yet uniform modification of red toon lignin. The extent of the derivatization processes was confirmed by iodine titration and precipitation titration. The prepared material have been characterised by some physical and chemical methods such as analytical determination, FTIR, SEM and EDX analysis. The analytical results supported highest sulphur content of 47.93% in thiomer. Synthesised green thiomers have been explored as arsenic ion sorbent at 60ppm. The result showed maximum sorption efficiency 86-90% for Fe(III) in aqueous system.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84540552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/JBCC.2019.V05I01.005
Ashish Yasin Hawaldar, S. D. Vaidya
: A series of novel N-substituted benzimidazole derivatives have been synthesized by the condensation of ortho-phenylenediamine and urea, subsequent reaction of the product obtained with Phosphoryl chloride to give 2-Chloro-1 H -benzimidazole. Using this compound alkylation done at the benzimidazole –NH position with different benzyl halide reagent leading to the functionalized derivatives. Newly synthesized derivatives (6a to 6h) have been elucidated on the basis of spectral and analytical data like melting point, IR, 1 H-NMR, Mass spectroscopy and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. This displayed some promising results towards testing organism in-vitro.
以邻苯二胺和尿素为原料缩合合成了一系列新型n -取代苯并咪唑衍生物，与氯磷反应得到2-氯-1 H -苯并咪唑。利用该化合物在苯并咪唑-NH位置与不同的苄基卤化物试剂进行烷基化反应，得到功能化衍生物。根据熔点、IR、1h - nmr、质谱和元素分析等光谱和分析数据，对新合成的6a ~ 6h衍生物进行了鉴定。对合成的化合物进行抑菌活性筛选。这在体外测试生物体方面显示了一些有希望的结果。
{"title":"Synthesis of Some Novel N-alkylated 2-chloro-Benzimidazole Derivatives and their Biological Evaluation","authors":"Ashish Yasin Hawaldar, S. D. Vaidya","doi":"10.33980/JBCC.2019.V05I01.005","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.005","url":null,"abstract":": A series of novel N-substituted benzimidazole derivatives have been synthesized by the condensation of ortho-phenylenediamine and urea, subsequent reaction of the product obtained with Phosphoryl chloride to give 2-Chloro-1 H -benzimidazole. Using this compound alkylation done at the benzimidazole –NH position with different benzyl halide reagent leading to the functionalized derivatives. Newly synthesized derivatives (6a to 6h) have been elucidated on the basis of spectral and analytical data like melting point, IR, 1 H-NMR, Mass spectroscopy and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. This displayed some promising results towards testing organism in-vitro.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73940459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/JBCC.2019.V05I01.024
S. Deshmukh, S. D. Vaidya
{"title":"Synthesis, Characterization and Biological Evaluation of New Nalkylated/N-acylated 2-[(4-bromobenzyl) sulfanyl]-1H-benzimidazole Derivatives","authors":"S. Deshmukh, S. D. Vaidya","doi":"10.33980/JBCC.2019.V05I01.024","DOIUrl":"https://doi.org/10.33980/JBCC.2019.V05I01.024","url":null,"abstract":"","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76003697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33980/jbcc.2019.v05i01.003
Nirmala Musmade, A. Jadhav, Priyanka Moin, Suvarna H Patil, Akhilesh Gupta
Usually, researchers find the difficulties for the development of novel drug delivery systems by implementing the novel technologies. Also there are lots of challenges to make these systems site specific for effective drug delivery for extended period of time. A novel biodegradable, injectable polymeric system namely in-situ forming implants (ISFIs) looks very promising drug delivery system. In-situ gel formation of drug delivery systems can be defined as a liquid formulation generating a solid or semisolid depot after administration. It is a blend of drug and biodegradable polymers dissolved or suspended in pharmaceutically acceptable water-miscible organic solvents. These are generally liquid formulations that form semi-solid or solid depots after injection at the injection site due to phase separation and provide a prolonged release over weeks to few months duration. After subcutaneous injection of ISFI the organic solvent dissipates into the surrounding tissue as water penetrates in, this leads to phase separation and precipitation of the polymer forming a depot (gel) at the injection site. The drug entrapped in the depot is then slowly released out into the surrounding body fluid due to the degradation of the polymers and finally reaches the systemic circulation. These high-value formulations ensure patient compliance; will contribute in the design and development of biotechnologically based products. The present review mainly focuses on advantages, disadvantages, classification, composition, methods and evaluation of in-situ gelling implants.
{"title":"An Overview of In Situ Gel Forming Implants: Current Approach Towards Alternative Drug Delivery System","authors":"Nirmala Musmade, A. Jadhav, Priyanka Moin, Suvarna H Patil, Akhilesh Gupta","doi":"10.33980/jbcc.2019.v05i01.003","DOIUrl":"https://doi.org/10.33980/jbcc.2019.v05i01.003","url":null,"abstract":"Usually, researchers find the difficulties for the development of novel drug delivery systems by implementing the novel technologies. Also there are lots of challenges to make these systems site specific for effective drug delivery for extended period of time. A novel biodegradable, injectable polymeric system namely in-situ forming implants (ISFIs) looks very promising drug delivery system. In-situ gel formation of drug delivery systems can be defined as a liquid formulation generating a solid or semisolid depot after administration. It is a blend of drug and biodegradable polymers dissolved or suspended in pharmaceutically acceptable water-miscible organic solvents. These are generally liquid formulations that form semi-solid or solid depots after injection at the injection site due to phase separation and provide a prolonged release over weeks to few months duration. After subcutaneous injection of ISFI the organic solvent dissipates into the surrounding tissue as water penetrates in, this leads to phase separation and precipitation of the polymer forming a depot (gel) at the injection site. The drug entrapped in the depot is then slowly released out into the surrounding body fluid due to the degradation of the polymers and finally reaches the systemic circulation. These high-value formulations ensure patient compliance; will contribute in the design and development of biotechnologically based products. The present review mainly focuses on advantages, disadvantages, classification, composition, methods and evaluation of in-situ gelling implants.","PeriodicalId":15083,"journal":{"name":"Journal of Biological and chemical Chronicles","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76091479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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