Pub Date : 2022-06-01DOI: 10.21608/jbaar.2022.246744
Farouk Hachem, I. Boualaoui, Ali Mikou, Zouaidia Fouad, A. Ibrahimi, H. Elsayegh, Y. Nouini
Xanthogranulomatous prostatitis is a rare chronic inflammatory condition and may simulate prostatic carcinoma both clinically and microscopically. Conservative treatment is recommended for xanthogranulomatous prostatitis, including the use of alpha-blockers and corticosteroids. Surgical options, such as transurethral prostatic resection or open adenomectomy, are reserved for patients who are severely symptomatic or who have failed conservative treatment.
{"title":"XANTHOGRANULOMATOUS PROSTATITIS","authors":"Farouk Hachem, I. Boualaoui, Ali Mikou, Zouaidia Fouad, A. Ibrahimi, H. Elsayegh, Y. Nouini","doi":"10.21608/jbaar.2022.246744","DOIUrl":"https://doi.org/10.21608/jbaar.2022.246744","url":null,"abstract":"Xanthogranulomatous prostatitis is a rare chronic inflammatory condition and may simulate prostatic carcinoma both clinically and microscopically. Conservative treatment is recommended for xanthogranulomatous prostatitis, including the use of alpha-blockers and corticosteroids. Surgical options, such as transurethral prostatic resection or open adenomectomy, are reserved for patients who are severely symptomatic or who have failed conservative treatment.","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76712058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-17DOI: 10.21608/jbaar.2022.237709
A. Hasan, Haneen A. Hameed
{"title":"Hepatic ameliorative role of Grape Seed Proanthocyanidin Extract against Ehrlich solid carcinoma-induced liver toxicity","authors":"A. Hasan, Haneen A. Hameed","doi":"10.21608/jbaar.2022.237709","DOIUrl":"https://doi.org/10.21608/jbaar.2022.237709","url":null,"abstract":"","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75487683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-05DOI: 10.21608/jbaar.2022.229094
N. Abdelateif, Abather Mohamed
: Background: Allo-immunization is a condition in which the body gains immunity, from another individual of the same species, against its cells. Blood group antibodies are called alloantibodies if they react with alloantigens on the red blood cells (RBCs) of other individuals. Immune antibodies are produced following exposure to foreign erythrocyte antigens through pregnancy or transfusion. Maternal alloimmunization, also known as iso-immunization, occurs when a woman's immune system is sensitized to foreign erythrocyte surface antigens, stimulating the production of immunoglobulin G (IgG) antibodies. Purpose: This study aimed to detect the frequency and specificity of alloantibodies against (RBCs) antigens among Sudanese multiparous women. Methods: This cross-sectional study was conducted on randomly selected 130 pregnant ladies, most of them were attending Soba teaching hospital and the remaining to Khartoum teaching hospital during the period from February-2008 to May-2008. Serum from each lady was collected. Each sample was grouped and screened for alloantibodies, then samples with positive antibody screening were tested for antibody identification using the gel agglutination method. Results: The overall frequency of alloantibodies detected among studied pregnant ladies was 10.8%. The results also revealed that an insignificant correlation was found between age, ethnic group, and presence of alloantibodies (( P-value : > 0.05); While a significant correlation was observed between the history of abortion, and the number of pregnancies and presence of alloantibodies ( P-value : < 0.05). Conclusion: In summary, we concluded that the alloantibodies were detected in one-tenth of the studied subjects with a significant association between detected antibodies and the number of pregnancies .
{"title":"Frequency and specificity of red blood cells alloantibodies among Sudanese multiparous women","authors":"N. Abdelateif, Abather Mohamed","doi":"10.21608/jbaar.2022.229094","DOIUrl":"https://doi.org/10.21608/jbaar.2022.229094","url":null,"abstract":": Background: Allo-immunization is a condition in which the body gains immunity, from another individual of the same species, against its cells. Blood group antibodies are called alloantibodies if they react with alloantigens on the red blood cells (RBCs) of other individuals. Immune antibodies are produced following exposure to foreign erythrocyte antigens through pregnancy or transfusion. Maternal alloimmunization, also known as iso-immunization, occurs when a woman's immune system is sensitized to foreign erythrocyte surface antigens, stimulating the production of immunoglobulin G (IgG) antibodies. Purpose: This study aimed to detect the frequency and specificity of alloantibodies against (RBCs) antigens among Sudanese multiparous women. Methods: This cross-sectional study was conducted on randomly selected 130 pregnant ladies, most of them were attending Soba teaching hospital and the remaining to Khartoum teaching hospital during the period from February-2008 to May-2008. Serum from each lady was collected. Each sample was grouped and screened for alloantibodies, then samples with positive antibody screening were tested for antibody identification using the gel agglutination method. Results: The overall frequency of alloantibodies detected among studied pregnant ladies was 10.8%. The results also revealed that an insignificant correlation was found between age, ethnic group, and presence of alloantibodies (( P-value : > 0.05); While a significant correlation was observed between the history of abortion, and the number of pregnancies and presence of alloantibodies ( P-value : < 0.05). Conclusion: In summary, we concluded that the alloantibodies were detected in one-tenth of the studied subjects with a significant association between detected antibodies and the number of pregnancies .","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86889664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-04DOI: 10.21608/jbaar.2022.228865
Khalil Alhalfawy, Bahgat A. Elfiky, A. Zahran, M. Zayed
Background: Hydrogen peroxide is currently the most widely used as an apoptosis inducer due to its broad cytotoxic efficacy against nearly all cell types. cytotoxicity is achieved over a wide range of doses Objective: To evaluate the cytotoxic effect of hydrogen peroxide on renal cell lines by detecting RIPK1. Methods: In this study, we used a Vero cell line treated with H 2 O 2 at concentrations 0.1 mM, 0.2 mM, 0.4 mM, 0.8 mM, and 1.6 mM and examined after 30 min,1hour,2hours,3hours, 4hours and 5 hours. by using MTT assay to detect cytotoxicity to cell line (by detecting cell viability). Spectrophotometrically measure the absorbance at a wavelength of 570 nm. Measure the background absorbance of multi-well plates at 690 nm and subtract from the 450 nm measurement. Sub-lethal dose to renal cell line is one treated with 1.6 mM for 5 hours. groups group 1: renal cell line as control which not treated by H2O2. group 2: Sub-lethal which renal cell line treated by concentration 1.6 mM of H2O2 for 5 hours. Results: H2O2 is cytotoxic to renal cell line by concentration from 0.1 mM to 1.6 mM. RIPK1 gene expressed in renal cell line treated by H2O2. The sublethal dose reached 1.6 mM for 5 hours. There is a significant difference between the 2 groups by detecting the expression of the RIPK1 gene.
{"title":"Induction of renal cell line apoptosis by hydrogen peroxide","authors":"Khalil Alhalfawy, Bahgat A. Elfiky, A. Zahran, M. Zayed","doi":"10.21608/jbaar.2022.228865","DOIUrl":"https://doi.org/10.21608/jbaar.2022.228865","url":null,"abstract":"Background: Hydrogen peroxide is currently the most widely used as an apoptosis inducer due to its broad cytotoxic efficacy against nearly all cell types. cytotoxicity is achieved over a wide range of doses Objective: To evaluate the cytotoxic effect of hydrogen peroxide on renal cell lines by detecting RIPK1. Methods: In this study, we used a Vero cell line treated with H 2 O 2 at concentrations 0.1 mM, 0.2 mM, 0.4 mM, 0.8 mM, and 1.6 mM and examined after 30 min,1hour,2hours,3hours, 4hours and 5 hours. by using MTT assay to detect cytotoxicity to cell line (by detecting cell viability). Spectrophotometrically measure the absorbance at a wavelength of 570 nm. Measure the background absorbance of multi-well plates at 690 nm and subtract from the 450 nm measurement. Sub-lethal dose to renal cell line is one treated with 1.6 mM for 5 hours. groups group 1: renal cell line as control which not treated by H2O2. group 2: Sub-lethal which renal cell line treated by concentration 1.6 mM of H2O2 for 5 hours. Results: H2O2 is cytotoxic to renal cell line by concentration from 0.1 mM to 1.6 mM. RIPK1 gene expressed in renal cell line treated by H2O2. The sublethal dose reached 1.6 mM for 5 hours. There is a significant difference between the 2 groups by detecting the expression of the RIPK1 gene.","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91422601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-20DOI: 10.21608/jbaar.2022.225891
R. Mohammed, N. Ali
Background: Sickle cell hemoglobinopathy is a genetic disorder caused by the presence of hemoglobin S (HbS), γG-158 (C→T) polymorphism plays an important function in the disease severity of sickle cell anemia, The XmnI restriction site at -158 position of the γG-gene is associated with increased expression of the γG-globin gene and higher production of HbF, Previous studies have suggested that a variety of genetic determents influence different clinical phenotypes. The genetic variants that modulate HbF levels have a very strong impact on ameliorating the clinical phenotype. Aim: This study aims to associate between Xmn1 (...γG-158 C→T ...) polymorphism and fetal hemoglobin level among Sudanese patients with SCA.Materials and methods: In this descriptive crosssectional study 60 blood samples from diagnostic cases were analyzed using a Hematology analyzer (Sysmex KX21N), capillary electrophoresis (MINICAP), using “G-spinTM Total DNA Extraction Kit”, PCR-RFLP techniques. Results: Patients with SCA were analyzed for Xmn1 polymorphism and association between this polymorphism and severity of SCA was evaluated, the presence of one XmnI (+/-) site CT 2% in SS patients compared with XmnI-/site CC98% had shown difference regarding HbF level, thus the Polymorphic association was founded. Conclusion: In our descriptive cross-sectional study we concluded that the effect of the polymorphism on the Hb F level was established.
背景:镰状细胞血红蛋白病是一种由血红蛋白S (HbS)存在引起的遗传性疾病，γG-158 (C→T)多态性在镰状细胞性贫血的疾病严重程度中起重要作用，γ g基因-158位置的XmnI限制性位点与γ g -珠蛋白基因的表达增加和HbF的产生有关，以往的研究表明，多种遗传因素影响不同的临床表型。调节HbF水平的遗传变异对改善临床表型有很强的影响。目的:本研究旨在探讨Xmn1(…苏丹SCA患者γG-158 C→T…)多态性与胎儿血红蛋白水平的关系材料和方法:在本描述性横断面研究中，使用血液学分析仪(Sysmex KX21N)，毛细管电泳(MINICAP)，使用“G-spinTM总DNA提取试剂盒”，PCR-RFLP技术分析60例诊断病例的血液样本。结果:对SCA患者进行Xmn1多态性分析，并评估该多态性与SCA严重程度的相关性，SS患者中有1个XmnI(+/-)位点(CT 2%)与XmnI-/位点(CC98%)在HbF水平上存在差异，从而建立了多态性关联。结论:在我们的描述性横断面研究中，我们得出结论，多态性对Hb F水平的影响是确定的。
{"title":"The association of the -158 XmnI γG globin polymorphism with HbF level in sickle cell anemia Sudanese Patients","authors":"R. Mohammed, N. Ali","doi":"10.21608/jbaar.2022.225891","DOIUrl":"https://doi.org/10.21608/jbaar.2022.225891","url":null,"abstract":"Background: Sickle cell hemoglobinopathy is a genetic disorder caused by the presence of hemoglobin S (HbS), γG-158 (C→T) polymorphism plays an important function in the disease severity of sickle cell anemia, The XmnI restriction site at -158 position of the γG-gene is associated with increased expression of the γG-globin gene and higher production of HbF, Previous studies have suggested that a variety of genetic determents influence different clinical phenotypes. The genetic variants that modulate HbF levels have a very strong impact on ameliorating the clinical phenotype. Aim: This study aims to associate between Xmn1 (...γG-158 C→T ...) polymorphism and fetal hemoglobin level among Sudanese patients with SCA.Materials and methods: In this descriptive crosssectional study 60 blood samples from diagnostic cases were analyzed using a Hematology analyzer (Sysmex KX21N), capillary electrophoresis (MINICAP), using “G-spinTM Total DNA Extraction Kit”, PCR-RFLP techniques. Results: Patients with SCA were analyzed for Xmn1 polymorphism and association between this polymorphism and severity of SCA was evaluated, the presence of one XmnI (+/-) site CT 2% in SS patients compared with XmnI-/site CC98% had shown difference regarding HbF level, thus the Polymorphic association was founded. Conclusion: In our descriptive cross-sectional study we concluded that the effect of the polymorphism on the Hb F level was established.","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90957376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-14DOI: 10.21608/jbaar.2022.224732
N. Emam, Aljohara Al-Otabi
{"title":"Protective Effects of Ambrosia maritima and Allium sativum Plant Extracts on Different Tissues of Envenomed mice with Leiurus quinquestriatus Scorpion Venom","authors":"N. Emam, Aljohara Al-Otabi","doi":"10.21608/jbaar.2022.224732","DOIUrl":"https://doi.org/10.21608/jbaar.2022.224732","url":null,"abstract":"","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81308053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08DOI: 10.21608/jbaar.2022.223518
H. El-emshaty, Somaia Osman, F. El‐Taweel, M. El-Hemaly, H. Ismail
Hoda M. El-Emshaty, Somaia M. Osman , Fathy M. El-Taweel, Mohamed M. El-Hemaly, Hisham Ismail 3 Gastrointestinal Surgery Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt Chemistry Dept., Faculty of Science, Damietta University, New Damietta, Egypt. Biochemistry Division, Chemistry Dept., Faculty of Science, Minia University, Minia, Egypt. Running title: Predictive force of serum 8-OHdG in HCV-chronic liver diseases *Corresponding Author: Dr. Hoda Mohamed El-Emshaty Professor of Biochemistry, Gastrointestinal Surgical Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt E-mail: elemshaty_h@yahoo.com DOI: 10.21608/jbaar.2022.223518 Abstract Reactive oxygen species (ROS) is excessively generated during tumor development yielding the oxidatively modified products of proteins and DNA. These DNA alterations could contribute to the development of cancer through the activation of oncogenes and inactivating tumor suppressor genes (TSGs). Therefore, 8-OHdG DNA oxidative damage and TP53 protein expression were evaluated amongst HCV-Chronic liver disease patients to explore their possible role in hepatocarcinogenesis and to predict HCC development at early stages. A total of 141 patients with HCV-related liver diseases; 69 with hepatocellular carcinoma and 72 with liver cirrhosis were enrolled in this study in addition to 56 healthy subjects. Serum 8-OHdG and TP53 expression by ELISA were markedly elevated in HCC patients compared to LC and healthy individuals (p<0.0001). A significant correlation was noted for 8-OHdG and TP53 with disease progression and tumor differentiation but not with tumor site. 8-OHdG and TP53 were highly (p<0.05) predicting for HCC at early stages and the diagnostic performance for discriminating HCC from LC by ROC curve showed the best AUC was recorded for 8-OHdG (0.745) followed by TP53 (0.667) with accuracy (87.2% and 82% respectively). Therefore, HCV-induced oxidative DNA damage could increase the carcinogenic potential of HCC development through the activation of TP53.
Hoda M. El-Emshaty, Somaia M. Osman, Fathy M. El-Taweel, Mohamed M. El-Hemaly, Hisham Ismail 3胃肠外科中心，曼苏拉大学医学院，曼苏拉，埃及，新达米埃塔，达米埃塔大学科学系化学系。埃及米尼亚大学理学院化学系生物化学系。运行标题:血清8-OHdG在hcv -慢性肝病中的预测力*通讯作者:Dr. Hoda Mohamed El-Emshaty生物化学教授，胃肠道外科中心，医学院，Mansoura大学，Mansoura，埃及E-mail: elemshaty_h@yahoo.com DOI: 10.21608/jbaar.2022.223518摘要活性氧(ROS)在肿瘤发展过程中过量产生，产生氧化修饰的蛋白质和DNA产物。这些DNA改变可能通过致癌基因的激活和肿瘤抑制基因(TSGs)的失活来促进癌症的发展。因此，我们在hcv -慢性肝病患者中评估8-OHdG DNA氧化损伤和TP53蛋白表达，探讨其在肝癌发生中的可能作用，并在早期预测HCC的发展。共141例hcv相关肝病患者;除56名健康受试者外，本研究还纳入了69名肝细胞癌患者和72名肝硬化患者。ELISA检测HCC患者血清8-OHdG和TP53表达水平明显高于LC和健康人群(p<0.0001)。8-OHdG和TP53与疾病进展和肿瘤分化有显著相关性，但与肿瘤部位无显著相关性。8-OHdG和TP53对HCC早期诊断具有较高的预测价值(p<0.05)， ROC曲线对HCC和LC的诊断效果显示，8-OHdG的AUC(0.745)最高，TP53的AUC(0.667)最低，准确率分别为87.2%和82%。因此，hcv诱导的DNA氧化损伤可能通过激活TP53增加HCC发展的致癌潜力。
{"title":"8-hydroxy-2'-deoxyguanosine and TP53 in Egyptian Patients with Hepatitis C Viral Chronic Liver Diseases: Insight into the Pathogenesis and Predictive Force","authors":"H. El-emshaty, Somaia Osman, F. El‐Taweel, M. El-Hemaly, H. Ismail","doi":"10.21608/jbaar.2022.223518","DOIUrl":"https://doi.org/10.21608/jbaar.2022.223518","url":null,"abstract":"Hoda M. El-Emshaty, Somaia M. Osman , Fathy M. El-Taweel, Mohamed M. El-Hemaly, Hisham Ismail 3 Gastrointestinal Surgery Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt Chemistry Dept., Faculty of Science, Damietta University, New Damietta, Egypt. Biochemistry Division, Chemistry Dept., Faculty of Science, Minia University, Minia, Egypt. Running title: Predictive force of serum 8-OHdG in HCV-chronic liver diseases *Corresponding Author: Dr. Hoda Mohamed El-Emshaty Professor of Biochemistry, Gastrointestinal Surgical Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt E-mail: elemshaty_h@yahoo.com DOI: 10.21608/jbaar.2022.223518 Abstract Reactive oxygen species (ROS) is excessively generated during tumor development yielding the oxidatively modified products of proteins and DNA. These DNA alterations could contribute to the development of cancer through the activation of oncogenes and inactivating tumor suppressor genes (TSGs). Therefore, 8-OHdG DNA oxidative damage and TP53 protein expression were evaluated amongst HCV-Chronic liver disease patients to explore their possible role in hepatocarcinogenesis and to predict HCC development at early stages. A total of 141 patients with HCV-related liver diseases; 69 with hepatocellular carcinoma and 72 with liver cirrhosis were enrolled in this study in addition to 56 healthy subjects. Serum 8-OHdG and TP53 expression by ELISA were markedly elevated in HCC patients compared to LC and healthy individuals (p<0.0001). A significant correlation was noted for 8-OHdG and TP53 with disease progression and tumor differentiation but not with tumor site. 8-OHdG and TP53 were highly (p<0.05) predicting for HCC at early stages and the diagnostic performance for discriminating HCC from LC by ROC curve showed the best AUC was recorded for 8-OHdG (0.745) followed by TP53 (0.667) with accuracy (87.2% and 82% respectively). Therefore, HCV-induced oxidative DNA damage could increase the carcinogenic potential of HCC development through the activation of TP53.","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84242289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-06DOI: 10.21608/jbaar.2022.223360
Mahmoud Matar Mohammad Abu Rakhey, Samir Ali Abd El-Kaream, D. Ma
Sono-Photodynamic Leukemia Treatment: Up-To-Date Cancer Treatment Modality Mahmoud Matar Mohammad Abu Rakhey*, Samir Ali Abd El-Kaream, Daoxin Ma Qilu Hospital, China niversity Department of Hematology, Shandong U 1 Department of Applied Medical Chemistry, Alexandria University-Medical Research Institute, Egypt , * 1 akhey Mahmoud Matar Mohammad Abu R : nding author Correspo * Department of Hematology, Shandong University-Qilu Hospital, China Mahmoud@mail.sdu.edu.cn : mail institutional e ORCID iD: https://orcid.org/0000-0001-5318-5051
超声光动力白血病治疗:最新癌症治疗方式Mahmoud Matar Mohammad Abu Rakhey*， Samir Ali Abd El-Kaream，道新马齐鲁医院，中国大学血液科，山东1埃及亚历山大大学医学研究所应用药物化学系，* 1 akhey Mahmoud Matar Mohammad Abu R:通讯作者*山东大学齐鲁医院血液科Mahmoud@mail.sdu.edu.cn:邮件机构ORCID iD: https://orcid.org/0000-0001-5318-5051
{"title":"Folic Acid Conjugated Graphene Oxide Graviola Nanoparticle for Sono-Photodynamic Leukemia Treatment: Up-To-Date Cancer Treatment Modality","authors":"Mahmoud Matar Mohammad Abu Rakhey, Samir Ali Abd El-Kaream, D. Ma","doi":"10.21608/jbaar.2022.223360","DOIUrl":"https://doi.org/10.21608/jbaar.2022.223360","url":null,"abstract":"Sono-Photodynamic Leukemia Treatment: Up-To-Date Cancer Treatment Modality Mahmoud Matar Mohammad Abu Rakhey*, Samir Ali Abd El-Kaream, Daoxin Ma Qilu Hospital, China niversity Department of Hematology, Shandong U 1 Department of Applied Medical Chemistry, Alexandria University-Medical Research Institute, Egypt , * 1 akhey Mahmoud Matar Mohammad Abu R : nding author Correspo * Department of Hematology, Shandong University-Qilu Hospital, China Mahmoud@mail.sdu.edu.cn : mail institutional e ORCID iD: https://orcid.org/0000-0001-5318-5051","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83909685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.21608/jbaar.2022.222520
Marwa N. Atallah, Amira S. Abd El-Gaber
a Vertebrates, Comparative Anatomy, and Embryology, Zoology Department, Faculty of Science-Menoufia University, Egypt. b Chemistry Department, Faculty of Science, Menoufia University, Egypt Correspondence: Dr. Marwa Atallah, Lecturer of Vertebrates Embryology and Comparative Anatomy – Zoology Department – Faculty of Science – Menoufia University – Egypt. Email: Marwa.atallah@science.menofia.edu.eg Tel: +201022664113
{"title":"In utero exposure of green coffee extract alters rat fetal neurodevelopment in a dose dependent manner","authors":"Marwa N. Atallah, Amira S. Abd El-Gaber","doi":"10.21608/jbaar.2022.222520","DOIUrl":"https://doi.org/10.21608/jbaar.2022.222520","url":null,"abstract":"a Vertebrates, Comparative Anatomy, and Embryology, Zoology Department, Faculty of Science-Menoufia University, Egypt. b Chemistry Department, Faculty of Science, Menoufia University, Egypt Correspondence: Dr. Marwa Atallah, Lecturer of Vertebrates Embryology and Comparative Anatomy – Zoology Department – Faculty of Science – Menoufia University – Egypt. Email: Marwa.atallah@science.menofia.edu.eg Tel: +201022664113","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78514928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.21608/jbaar.2021.237395
S. Alabd, Ahmed Mahmoud
: Background: Creatine kinase (CK), which is a marker of muscle damage, was also often found to be elevated in deceased COVID-19 patients and those with severe disease, Therefore, higher CK could be used as a prognostic marker to indicate a more severe clinical picture of COVID-19. Patients and methods: This study included 225 out-hospitalized patients with confirmed COVID-19 infection, these study subjects were randomly selected irrespective of the age group and both genders were included, Assay procedure as manufactory instructions and Reagents of Spectrum diagnostics, optimized DGKC/IFCC liquid reagent, Egypt are used. Results: This study showed male gender was more frequent (n=135, 60%) than the female gender (n=90, 40%). This study reveals high serum CK levels in 45 patients (20%), which has a sensitivity of 20% as a biomarker for COVID-19 diagnosis in out-hospitalized patients (Outpatients and patients under home observation), with a p-value is <0.001 which is less than 0.05. Conclusion: CK has a sensitivity of 20% in out-hospitalized patients (Outpatients and patients under home observation), thus elevated CK is best used as a rule-in test rather than a rule-out test.
{"title":"The prognostic value of elevated creatine kinase as an Independent Prognostic Factor for COVID-19 mild infection","authors":"S. Alabd, Ahmed Mahmoud","doi":"10.21608/jbaar.2021.237395","DOIUrl":"https://doi.org/10.21608/jbaar.2021.237395","url":null,"abstract":": Background: Creatine kinase (CK), which is a marker of muscle damage, was also often found to be elevated in deceased COVID-19 patients and those with severe disease, Therefore, higher CK could be used as a prognostic marker to indicate a more severe clinical picture of COVID-19. Patients and methods: This study included 225 out-hospitalized patients with confirmed COVID-19 infection, these study subjects were randomly selected irrespective of the age group and both genders were included, Assay procedure as manufactory instructions and Reagents of Spectrum diagnostics, optimized DGKC/IFCC liquid reagent, Egypt are used. Results: This study showed male gender was more frequent (n=135, 60%) than the female gender (n=90, 40%). This study reveals high serum CK levels in 45 patients (20%), which has a sensitivity of 20% as a biomarker for COVID-19 diagnosis in out-hospitalized patients (Outpatients and patients under home observation), with a p-value is <0.001 which is less than 0.05. Conclusion: CK has a sensitivity of 20% in out-hospitalized patients (Outpatients and patients under home observation), thus elevated CK is best used as a rule-in test rather than a rule-out test.","PeriodicalId":15163,"journal":{"name":"Journal of Bioscience and Applied Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82908789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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