Pub Date : 2020-06-05DOI: 10.15406/JCPCR.2020.11.00428
Chintav Shah, Simeon Jaggenauth, Patrick Pathappillil, Risha Sinha
Testicular liposarcoma is a very uncommon pathology associated with testicular cancer. 1 Paratesticular soft tissue tumors are rare entities with malignant subtypes accounting for 30% of cases. 2 Often misdiagnosed, testicular liposarcoma must be considered in the differential diagnosis of a groin mass. 1 There are only few cases of the giant testicular liposarcoma of more than 10cm reported in the literature. We present the case of a 62yr old male who presented to urology for a mass in the groin which was thought to be an inguinal hernia. The patient had some associated testicular pain therefore an ultrasound was performed identifying a 7.1 x 1.5cm mass. He underwent a left orchiectomy with removal of the associated mass which showed a well differentiated liposarcoma of a sclerosing variant. The surgical margins were negative however; the patient did undergo a metastatic workup with a CT of abdomen and pelvis that was unremarkable.
摘要睾丸脂肪肉瘤是一种罕见的与睾丸癌相关的病理。1睾丸旁软组织肿瘤是罕见的肿瘤，恶性亚型约占30%。睾丸脂肪肉瘤常被误诊，在鉴别诊断腹股沟肿块时必须加以考虑。1文献报道的大于10cm的巨大睾丸脂肪肉瘤病例很少。我们提出的情况下，62岁的男性谁提出了一个肿块在腹股沟泌尿科认为是腹股沟疝。患者伴有睾丸疼痛，因此超声检查发现7.1 x 1.5cm肿块。他接受了左睾丸切除术，切除了相关肿块，结果显示为分化良好的硬化型脂肪肉瘤。然而，手术切缘为阴性;患者确实接受了腹部和骨盆的CT检查，但没有明显的转移。
{"title":"Testicular liposarcoma: a rare form of testicular cancer","authors":"Chintav Shah, Simeon Jaggenauth, Patrick Pathappillil, Risha Sinha","doi":"10.15406/JCPCR.2020.11.00428","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00428","url":null,"abstract":"Testicular liposarcoma is a very uncommon pathology associated with testicular cancer. 1 Paratesticular soft tissue tumors are rare entities with malignant subtypes accounting for 30% of cases. 2 Often misdiagnosed, testicular liposarcoma must be considered in the differential diagnosis of a groin mass. 1 There are only few cases of the giant testicular liposarcoma of more than 10cm reported in the literature. We present the case of a 62yr old male who presented to urology for a mass in the groin which was thought to be an inguinal hernia. The patient had some associated testicular pain therefore an ultrasound was performed identifying a 7.1 x 1.5cm mass. He underwent a left orchiectomy with removal of the associated mass which showed a well differentiated liposarcoma of a sclerosing variant. The surgical margins were negative however; the patient did undergo a metastatic workup with a CT of abdomen and pelvis that was unremarkable.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86042578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-23DOI: 10.15406/JCPCR.2020.11.00430
R. Pintican, M. Mureşan, A. Chiorean, V. Bintintan, V. Bura, M. Duma
Renal cell carcinoma (RCC) is notorious for its uncommon metastatic location. We present a rare case of goiter as a RCC metastatic site. As case particularities, besides the goiter that made practically impossible the ultrasound diagnosis of the metastasis, this seemed to be correlated with an unexplained high level of alkaline phosphatase (AP). AP persisted from the time of kidney cancer diagnosis, after nephrectomy and reached a normal value only after thyroidectomy. Currently, there are no guidelines to indicate FDG-PET in RCC patients. Thereby, we will present the challenging ultrasound diagnosis together with case management particularities.
{"title":"Thyroid, uncommon metastatic site for renal cell carcinoma – practical challenges","authors":"R. Pintican, M. Mureşan, A. Chiorean, V. Bintintan, V. Bura, M. Duma","doi":"10.15406/JCPCR.2020.11.00430","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00430","url":null,"abstract":"Renal cell carcinoma (RCC) is notorious for its uncommon metastatic location. We present a rare case of goiter as a RCC metastatic site. As case particularities, besides the goiter that made practically impossible the ultrasound diagnosis of the metastasis, this seemed to be correlated with an unexplained high level of alkaline phosphatase (AP). AP persisted from the time of kidney cancer diagnosis, after nephrectomy and reached a normal value only after thyroidectomy. Currently, there are no guidelines to indicate FDG-PET in RCC patients. Thereby, we will present the challenging ultrasound diagnosis together with case management particularities.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79356590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-19DOI: 10.15406/JCPCR.2020.11.00427
J. Prasad, Arvind Kumar, Rajeshwari A. Biradar
Background: For effective planning and administrative purpose, a precise estimate of burden due to tobacco and projection figure is essential. There were some studies in India, reporting tobacco-related cancers. However, there is no observable study in India, especially for these backward and forward state, attempting to assess cancers due to tobacco for measuring the geographical variations. Hence, this study tried to highlights geographic variation between one from developed state is as Kerala, and another one is from not so well-developed state as Bihar in India. Materials and methods: Tobacco prevalence, the relative risk of cancer due to tobacco, incidence rates of tobacco-related cancers, and population were obtained respectively from recent five rounds of Nation Sample Survey, our recently published study, reports of Population-Based Cancer Registries, and projections of Registrar General of India. Prasad and Dhar published generalised Population Attributable Risk method (2018) was used to assess cancer due to tobacco and regression method for prediction. Results: The burden of cancer cases due to tobacco was found highest in the state of Bihar (23,679), while in Kerala, it was 5,981 in the year 2015 and increased to 42,244 and 6,646 by 2025 in Bihar and Kerala respectively. Lung cancer is the leading cancer sites followed by mouth and tongue cancers. In Kerala, the proportion of smoking is found to be high and lead to the higher proportions of larynx cancers (61percent) followed by oropharynx (59 percent) and lung cancer (58 percent) and are likely to increase from 2015 to 2025 slightly. In Bihar, around three fourth of mouth cancers cases being due to chewing followed by oesophagus (59 percent), tongue (54 percent) and so on. Conclusion: Present study reports the absolute burden of cancer due to tobacco, Tobacco- Related Cancer as well as a percent change of it for Kerala and Bihar till 2025. It might be helpful to policy planners and administrators in decision making relating to anti-tobacco measures.
{"title":"The burden of cancer cases attributable to tobacco in India: case of Kerala and Bihar states","authors":"J. Prasad, Arvind Kumar, Rajeshwari A. Biradar","doi":"10.15406/JCPCR.2020.11.00427","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00427","url":null,"abstract":"Background: For effective planning and administrative purpose, a precise estimate of burden due to tobacco and projection figure is essential. There were some studies in India, reporting tobacco-related cancers. However, there is no observable study in India, especially for these backward and forward state, attempting to assess cancers due to tobacco for measuring the geographical variations. Hence, this study tried to highlights geographic variation between one from developed state is as Kerala, and another one is from not so well-developed state as Bihar in India. Materials and methods: Tobacco prevalence, the relative risk of cancer due to tobacco, incidence rates of tobacco-related cancers, and population were obtained respectively from recent five rounds of Nation Sample Survey, our recently published study, reports of Population-Based Cancer Registries, and projections of Registrar General of India. Prasad and Dhar published generalised Population Attributable Risk method (2018) was used to assess cancer due to tobacco and regression method for prediction. Results: The burden of cancer cases due to tobacco was found highest in the state of Bihar (23,679), while in Kerala, it was 5,981 in the year 2015 and increased to 42,244 and 6,646 by 2025 in Bihar and Kerala respectively. Lung cancer is the leading cancer sites followed by mouth and tongue cancers. In Kerala, the proportion of smoking is found to be high and lead to the higher proportions of larynx cancers (61percent) followed by oropharynx (59 percent) and lung cancer (58 percent) and are likely to increase from 2015 to 2025 slightly. In Bihar, around three fourth of mouth cancers cases being due to chewing followed by oesophagus (59 percent), tongue (54 percent) and so on. Conclusion: Present study reports the absolute burden of cancer due to tobacco, Tobacco- Related Cancer as well as a percent change of it for Kerala and Bihar till 2025. It might be helpful to policy planners and administrators in decision making relating to anti-tobacco measures.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"17 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91474734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.15406/JCPCR.2020.11.00426
Sarah Alrubaish, M. Renaud
An elevation of BHCG has been documented only in rare case reports of mesenchymal tumors, however, it is usually found to be high in germ cell tumors. 1 BHCG production in patients with mesenchymal tumors has been discussed as a paraneoplastic phenomenon as well as associated with bad prognoses. 2,3
{"title":"Is BHCG a good tumor marker for aggressive uterine leiomyosarcoma? case report","authors":"Sarah Alrubaish, M. Renaud","doi":"10.15406/JCPCR.2020.11.00426","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00426","url":null,"abstract":"An elevation of BHCG has been documented only in rare case reports of mesenchymal tumors, however, it is usually found to be high in germ cell tumors. 1 BHCG production in patients with mesenchymal tumors has been discussed as a paraneoplastic phenomenon as well as associated with bad prognoses. 2,3","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"248 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82900633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.15406/JCPCR.2020.11.00425
I. Ahalli, K. Messoudi, Raihana Boujarnija, K. Darif, L. Amaadour, K. Oualla, Z. Benbrahim, Samia Arif, N. Mellas
Background: Lung cancer is the main cause of cancer-related death worldwide. Small cell lung cancer (SCLC) represents 15-20% of all lung cancers, it is an aggressive neoplasia, with a 5-year mortality of 90% or more. The aim of this study was to evaluate the epidemiological and clinical features, treatment outcome and survival for patients with SCLC treated in medical oncology department during the period from 2010 to 2018. Material and methods: It is a retrospective study including Small cell lung cancer (SCLC) treated in the department of Medical Oncology at Hassan II University hospital in Fes, from January 2010 to December 2018. Collection of data was obtained through computerized records of patients. The survival was analyzed by the Kaplan-Meier method. Results: The mean age was 59 years. Almost all patients were current smokers. The most frequent symptoms on admission were dyspnea, chest pain and hemoptysis. The stages of SCLC were limited disease in 17 (24,3%) and extensive disease in 53 (75,7%) patients. Contra lateral lung was the most common site of metastasis (42.6%) followed by adrenal gland, brain, liver and bone. The median survival was 25.2, 17.2 and 21.3 months for LS, ES and overall patients, respectively. Conclusion: In conclusion, demographic and clinical features of the patients were similar with the literature. We found a better survival than reported in literature.
{"title":"Small cell lung cancer: a Moroccan retrospective study of 70 cases","authors":"I. Ahalli, K. Messoudi, Raihana Boujarnija, K. Darif, L. Amaadour, K. Oualla, Z. Benbrahim, Samia Arif, N. Mellas","doi":"10.15406/JCPCR.2020.11.00425","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00425","url":null,"abstract":"Background: Lung cancer is the main cause of cancer-related death worldwide. Small cell lung cancer (SCLC) represents 15-20% of all lung cancers, it is an aggressive neoplasia, with a 5-year mortality of 90% or more. The aim of this study was to evaluate the epidemiological and clinical features, treatment outcome and survival for patients with SCLC treated in medical oncology department during the period from 2010 to 2018. Material and methods: It is a retrospective study including Small cell lung cancer (SCLC) treated in the department of Medical Oncology at Hassan II University hospital in Fes, from January 2010 to December 2018. Collection of data was obtained through computerized records of patients. The survival was analyzed by the Kaplan-Meier method. Results: The mean age was 59 years. Almost all patients were current smokers. The most frequent symptoms on admission were dyspnea, chest pain and hemoptysis. The stages of SCLC were limited disease in 17 (24,3%) and extensive disease in 53 (75,7%) patients. Contra lateral lung was the most common site of metastasis (42.6%) followed by adrenal gland, brain, liver and bone. The median survival was 25.2, 17.2 and 21.3 months for LS, ES and overall patients, respectively. Conclusion: In conclusion, demographic and clinical features of the patients were similar with the literature. We found a better survival than reported in literature.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72595548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-16DOI: 10.15406/JCPCR.2020.11.00424
Fahimeh Moradi, Morteza Hajihosseini, Elham Khodayari-Moez, I. Dinu
Introduction: Genome wide association studies (GWAS) have been widely used in recent years to identify new information on genetic variants which are associated with complex trait in many diseases. Advances in identifying the Single Nucleotide Polymorphisms (SNPs) facilitate the study of etiologies of common disorders including cancers, inflammatory bowel diseases (IBD) and colorectal cancer. Variations in gene expression demonstrate that transcript levels of many RNAs behave as heritable quantitative traits. Studying the genetics of gene expression can provide additional power to the roles of GWAS variants. Expression quantitative trait loci (eQTL) mapping links the genome-wide SNPs with RNA expression. Methods: In this study, we performed expression quantitative trait loci (eQTL) analysis using the Matrix eQTL R package. This technique implements matrix covariance calculation and efficiently runs ANOVA and linear regression analysis for eQTL studies. The statistical test determines the association between SNP and gene expression, where the null hypothesis is no association between genotype and phenotypes. False Discovery Rate (FDR) is used to identify significant cis and trans eQTL and adjust for multiple hypothesis testing. Results: We applied matrix eQTL to a real data set consisting of 730,256 SNP and 33,298 RNA for 173 samples. SNPs with minor allele frequency (MAF) less than 0.05 and those violating the Hardy_Weinberg equilibrium (HWE), were excluded from the study. In this study, 15,408 cis eQTL and 27,562 trans eQTL are identified at a FDR less than 0.05, corresponding to p value thresholds of 8e-5 and 1e-8, respectively. Conclusion: We found out that matrix eQTL is a computationally efficient and user friendly method for analysis of eQTL studies. Our application provides insight into the genomic architecture of gene regulation in inflammatory bowel disease (IBD).
近年来，基因组全关联研究(Genome wide association studies, GWAS)被广泛用于识别与许多疾病复杂性状相关的遗传变异的新信息。单核苷酸多态性(snp)鉴定的进展促进了癌症、炎症性肠病(IBD)和结直肠癌等常见疾病病因的研究。基因表达的变化表明，许多rna的转录水平表现为可遗传的数量性状。研究基因表达的遗传学可以为GWAS变体的作用提供额外的动力。表达数量性状位点(eQTL)定位将全基因组snp与RNA表达联系起来。方法:本研究使用Matrix eQTL R包进行表达数量性状位点(eQTL)分析。该技术实现了矩阵协方差计算，并有效地对eQTL研究进行方差分析和线性回归分析。统计检验确定SNP和基因表达之间的关联，其中零假设是基因型和表型之间没有关联。错误发现率(FDR)用于识别显著的顺式和反式eQTL，并对多假设检验进行调整。结果:我们将矩阵eQTL应用于173个样本的真实数据集，该数据集包含730,256个SNP和33,298个RNA。次要等位基因频率(MAF)小于0.05和违反Hardy_Weinberg平衡(HWE)的snp被排除在研究之外。本研究共鉴定出15408个顺式eQTL和27562个反式eQTL, FDR小于0.05，分别对应于p值阈值8e-5和1e-8。结论:矩阵eQTL是一种计算效率高、易于使用的eQTL分析方法。我们的应用程序为炎症性肠病(IBD)基因调控的基因组结构提供了见解。
{"title":"An application of matrix eQTL to billions hypothesis testing to identify expression quantitative trait loci in genome wide association studies of inflammatory bowel disease","authors":"Fahimeh Moradi, Morteza Hajihosseini, Elham Khodayari-Moez, I. Dinu","doi":"10.15406/JCPCR.2020.11.00424","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00424","url":null,"abstract":"Introduction: Genome wide association studies (GWAS) have been widely used in recent years to identify new information on genetic variants which are associated with complex trait in many diseases. Advances in identifying the Single Nucleotide Polymorphisms (SNPs) facilitate the study of etiologies of common disorders including cancers, inflammatory bowel diseases (IBD) and colorectal cancer. Variations in gene expression demonstrate that transcript levels of many RNAs behave as heritable quantitative traits. Studying the genetics of gene expression can provide additional power to the roles of GWAS variants. Expression quantitative trait loci (eQTL) mapping links the genome-wide SNPs with RNA expression. Methods: In this study, we performed expression quantitative trait loci (eQTL) analysis using the Matrix eQTL R package. This technique implements matrix covariance calculation and efficiently runs ANOVA and linear regression analysis for eQTL studies. The statistical test determines the association between SNP and gene expression, where the null hypothesis is no association between genotype and phenotypes. False Discovery Rate (FDR) is used to identify significant cis and trans eQTL and adjust for multiple hypothesis testing. Results: We applied matrix eQTL to a real data set consisting of 730,256 SNP and 33,298 RNA for 173 samples. SNPs with minor allele frequency (MAF) less than 0.05 and those violating the Hardy_Weinberg equilibrium (HWE), were excluded from the study. In this study, 15,408 cis eQTL and 27,562 trans eQTL are identified at a FDR less than 0.05, corresponding to p value thresholds of 8e-5 and 1e-8, respectively. Conclusion: We found out that matrix eQTL is a computationally efficient and user friendly method for analysis of eQTL studies. Our application provides insight into the genomic architecture of gene regulation in inflammatory bowel disease (IBD).","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90417924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-15DOI: 10.15406/JCPCR.2020.11.00423
Chintav Shah, S. Jaggernauth, V. A. Ayapati, B. o'Brian
Retroperitoneal liposarcomas are a heterogenous group of mesenchymal tumors that have a wide spectrum of histological subtypes and vague clinical presentation. 1 They are locally invasive and the peak incidence is in the 5th decade. 2 They account for 0.1-0.2% of all solid tumors and 15% of all soft-tissue tumors. 2 Liposarcomas are usually large and occur most frequently in the lower extremities, in the retroperitoneal, perineal and mesenteric region. 2 In the retroperitoneum, they grow without symptoms due to the ability of the abdominal cavity to accommodate these slowly expanding masses. 2 We present the case of 72yr old male who presented to urology and oncology due to the diagnosis of igh grade Gleason 9 prostate adenocarcinoma and a history of Agent Orange exposure. In the process of his workup, he complained of feeling full and gaining weight gain despite his best efforts at dieting and weight loss. Due to his abdominal distention, a CT scan of the abdomen and pelvis was performed which demonstrated 2 large fat containing intra abdominal masses suspicious for liposarcoma.
{"title":"Retroperitoneal liposarcoma: an unusual case of weight gain despite weight loss measures","authors":"Chintav Shah, S. Jaggernauth, V. A. Ayapati, B. o'Brian","doi":"10.15406/JCPCR.2020.11.00423","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00423","url":null,"abstract":"Retroperitoneal liposarcomas are a heterogenous group of mesenchymal tumors that have a wide spectrum of histological subtypes and vague clinical presentation. 1 They are locally invasive and the peak incidence is in the 5th decade. 2 They account for 0.1-0.2% of all solid tumors and 15% of all soft-tissue tumors. 2 Liposarcomas are usually large and occur most frequently in the lower extremities, in the retroperitoneal, perineal and mesenteric region. 2 In the retroperitoneum, they grow without symptoms due to the ability of the abdominal cavity to accommodate these slowly expanding masses. 2 We present the case of 72yr old male who presented to urology and oncology due to the diagnosis of igh grade Gleason 9 prostate adenocarcinoma and a history of Agent Orange exposure. In the process of his workup, he complained of feeling full and gaining weight gain despite his best efforts at dieting and weight loss. Due to his abdominal distention, a CT scan of the abdomen and pelvis was performed which demonstrated 2 large fat containing intra abdominal masses suspicious for liposarcoma.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"186 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76770700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-18DOI: 10.15406/JCPCR.2020.11.00422
K. Elboukhari, A. Rasso, S. Elloudi, H. Baybay, Z. Douhi, F. Mernissi
epidermis and dermis, with a triphasic evolution: alopecic patch with underdeveloped adnexal structures. In puberty, the second phase shows a proliferative and veracious plaque. While the third phase is characterized by the occurrence of benign or more rarely invasive tumors in the preexistent plaque. Dermoscopy finds an important place in the characterization of these stages of evolution, and especially in the detection of transformation. 10-20% of sebaceous nevus is transformed into benign or malignant tumors that Abstract Jadassohn nevus is a congenital hamartoma that is characterized by natural evolution in three stages, with a risk of malignancies occurring in the last phase. This benign adnexal tumor often affects the face and scalp. Dermoscopy can provide a major help for detecting transforming tumors. We report the case of a senile sebaceous Nevus which has been diagnosed after the occurrence of Basal cell carcinoma in a 60 years old man. The originality of this observation remains in the rarity of the pseudo glandular basal cell carcinoma that, in the best of our knowledge, has never been reported in underlying nevus sebaceous.
{"title":"Senile sebaceous nevus degenerating to a pseudo glandular basal cell carcinoma","authors":"K. Elboukhari, A. Rasso, S. Elloudi, H. Baybay, Z. Douhi, F. Mernissi","doi":"10.15406/JCPCR.2020.11.00422","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00422","url":null,"abstract":"epidermis and dermis, with a triphasic evolution: alopecic patch with underdeveloped adnexal structures. In puberty, the second phase shows a proliferative and veracious plaque. While the third phase is characterized by the occurrence of benign or more rarely invasive tumors in the preexistent plaque. Dermoscopy finds an important place in the characterization of these stages of evolution, and especially in the detection of transformation. 10-20% of sebaceous nevus is transformed into benign or malignant tumors that Abstract Jadassohn nevus is a congenital hamartoma that is characterized by natural evolution in three stages, with a risk of malignancies occurring in the last phase. This benign adnexal tumor often affects the face and scalp. Dermoscopy can provide a major help for detecting transforming tumors. We report the case of a senile sebaceous Nevus which has been diagnosed after the occurrence of Basal cell carcinoma in a 60 years old man. The originality of this observation remains in the rarity of the pseudo glandular basal cell carcinoma that, in the best of our knowledge, has never been reported in underlying nevus sebaceous.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73888872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-11DOI: 10.15406/JCPCR.2020.11.00420
Sonam Sharma, S. Sharma
of epithelial cells were also apparent. Cellular pleomorphism was absent (Figure 4). These histopathological findings pointed towards the final diagnosis of a benign chondroid syringoma (eccrine type) of the left foot. Immunohistochemistry (IHC) was also performed, which revealed a strong positivity of inner epithelial layer for cytokeratin (CK) 7 as well as epithelial membrane antigen (EMA) and the outer myoepithelial layer for vimentin, S100 and p63. A negative immunoexpression of tumor cells for p15, p16 and desmin was seen. The post-operative period of the patient was uneventful. There was no evidence of recurrence of the lesion during her 2 year follow-up period. Abstract Chondroid syringoma is a rare skin appendageal tumor which is most commonly encountered in the head and neck region. We herein report an unusual case of a benign chondroid syringoma of the left foot in a 40-year-old female which posed as a diagnostic conundrum. The approach to such a case, differential diagnosis and the management of this rare entity is also presented.
{"title":"Benign chondroid syringoma of foot: a clinical dilemma","authors":"Sonam Sharma, S. Sharma","doi":"10.15406/JCPCR.2020.11.00420","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00420","url":null,"abstract":"of epithelial cells were also apparent. Cellular pleomorphism was absent (Figure 4). These histopathological findings pointed towards the final diagnosis of a benign chondroid syringoma (eccrine type) of the left foot. Immunohistochemistry (IHC) was also performed, which revealed a strong positivity of inner epithelial layer for cytokeratin (CK) 7 as well as epithelial membrane antigen (EMA) and the outer myoepithelial layer for vimentin, S100 and p63. A negative immunoexpression of tumor cells for p15, p16 and desmin was seen. The post-operative period of the patient was uneventful. There was no evidence of recurrence of the lesion during her 2 year follow-up period. Abstract Chondroid syringoma is a rare skin appendageal tumor which is most commonly encountered in the head and neck region. We herein report an unusual case of a benign chondroid syringoma of the left foot in a 40-year-old female which posed as a diagnostic conundrum. The approach to such a case, differential diagnosis and the management of this rare entity is also presented.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73083687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-19DOI: 10.15406/JCPCR.2020.11.00419
Z. Youbi, S. Yossi, P. Sesques, H. Jouhadi
{"title":"High-grade testicular diffuse B lymphoma, a rare localization: a case report and review of the literature","authors":"Z. Youbi, S. Yossi, P. Sesques, H. Jouhadi","doi":"10.15406/JCPCR.2020.11.00419","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00419","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"93 1","pages":"23-25"},"PeriodicalIF":0.0,"publicationDate":"2020-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85685699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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