Pub Date : 2021-01-19DOI: 10.15406/JCPCR.2021.12.00447
J. Prasad, Arvind Kumar, Sudhirgouda Patil, Rajeshwari A. Biradar
Background: To study the source of increasing of COVID-19 cases in India, and also evaluate the afford government made to disconnect the chain of infectious disease. Materials and methods: COVID-19 data was obtained from website of Kaggle, which comprised details of individuals suffered with COVID-19 in India. Further, spot snap of COVID-19 situation as on 2 nd July, 2020 was also taken to fill up the gap susceptibility. Moreover, analysis was carried out by univariate and bi-variate techniques in Microsoft Excel 2016 statistical software. Results: In India, first five cases diagnosed with COVID were Indian, had international travel history and next 16 were Italian. These 21 cases were diagnosed in above mention states by 4th March, 2020, and when lockdown was declared, cases reached in 24 Indian states. The worst state with highest number of active cases about 160 per 100,000 population was in Delhi with Case Fatality Rate (44.6 per 1000 Cured and Deaths). Ladakh was second worst in highest number of active cases (147 per 100,000 population) followed by Maharashtra, Tamil Nadu and Goa. Case Fatality Rate was highest in Maharashtra (79.6 per 1000 Cured and Deaths) followed by Gujarat, Madhya Pradesh, West Bengal, Delhi etc. Delhi and Tamil Nadu was in worst situation in controlling of COVID-19 than the other state. The best state was Meghalaya with active cases 0.3 with alarming Case Fatality Rate 22.3 followed by Jharkhand. Conclusion: Indian travelled from different countries and Indian government were responsible for spreading of COVID-19 throughout country. Delhi and Tamil Nadu was in worst situation in controlling of COVID-19 than the other state. The reason for wide variation in active cases of COVID-19 may be unrest in community due to labour movement. Hence, for COVID-19 containment, there is need necessary steps for providing better health facilities, awareness of positive and negative effect of COVID-19 and restricting the state-wise public movement until COVID-19 will not come under control.
{"title":"Sources of spreading COVID-19 cases and afford made to control the infection in India","authors":"J. Prasad, Arvind Kumar, Sudhirgouda Patil, Rajeshwari A. Biradar","doi":"10.15406/JCPCR.2021.12.00447","DOIUrl":"https://doi.org/10.15406/JCPCR.2021.12.00447","url":null,"abstract":"Background: To study the source of increasing of COVID-19 cases in India, and also evaluate the afford government made to disconnect the chain of infectious disease. Materials and methods: COVID-19 data was obtained from website of Kaggle, which comprised details of individuals suffered with COVID-19 in India. Further, spot snap of COVID-19 situation as on 2 nd July, 2020 was also taken to fill up the gap susceptibility. Moreover, analysis was carried out by univariate and bi-variate techniques in Microsoft Excel 2016 statistical software. Results: In India, first five cases diagnosed with COVID were Indian, had international travel history and next 16 were Italian. These 21 cases were diagnosed in above mention states by 4th March, 2020, and when lockdown was declared, cases reached in 24 Indian states. The worst state with highest number of active cases about 160 per 100,000 population was in Delhi with Case Fatality Rate (44.6 per 1000 Cured and Deaths). Ladakh was second worst in highest number of active cases (147 per 100,000 population) followed by Maharashtra, Tamil Nadu and Goa. Case Fatality Rate was highest in Maharashtra (79.6 per 1000 Cured and Deaths) followed by Gujarat, Madhya Pradesh, West Bengal, Delhi etc. Delhi and Tamil Nadu was in worst situation in controlling of COVID-19 than the other state. The best state was Meghalaya with active cases 0.3 with alarming Case Fatality Rate 22.3 followed by Jharkhand. Conclusion: Indian travelled from different countries and Indian government were responsible for spreading of COVID-19 throughout country. Delhi and Tamil Nadu was in worst situation in controlling of COVID-19 than the other state. The reason for wide variation in active cases of COVID-19 may be unrest in community due to labour movement. Hence, for COVID-19 containment, there is need necessary steps for providing better health facilities, awareness of positive and negative effect of COVID-19 and restricting the state-wise public movement until COVID-19 will not come under control.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85153331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.15406/jcpcr.2021.12.00452
Muhammad Assem Kubtan, Sara Restum, Mazen Alloush
Prostate cancer is one of the most commonly occurring cancers in men, in 2018 there were 1.3 million new cases, according to a study conducted by the American Institute for Cancer Research, resulting in a significant rate of deaths. Needless to that there is a lack of efforts to make this disease noticeable by public as being made in carcinoma of Breast in women. Our study aims to determine the knowledge level of student at the Syrian Private University concerning as well as raising awareness about prostate cancer. A cross-sectional study was done at the Syrian Private University in Damascus, Syria, between December 2020 until January 2021. The sample included students of all years from different faculties in the Syrian Private University. The data was collected by a questionnaire to measure the awareness of prostate cancer. The total number of participants was 446, from all faculties including males and females. The number of students who have heard about Prostate Cancer was 73.1%, and the percentage, of those who heard about the PSA Test was 52%. localized malignant lesion and this will pave the way towards performing ultrasound guided needle biopsy or fine needle aspiration . Consequently, we are also looking forward to dedicate a month every year to enhance knowledge of prostatic malignancy, increase screening tests, and support free examinations sponsored by the health authority. By achieving this target we may be able to declare that we have a proper awareness program to combat prostate cancer in Syria.
前列腺癌是男性中最常见的癌症之一，根据美国癌症研究所(American Institute for cancer Research)的一项研究，2018年有130万新病例，导致死亡率很高。毋庸置疑，在使公众注意到这种疾病发生于女性乳腺癌方面缺乏努力。我们的研究旨在确定叙利亚私立大学学生关于前列腺癌的知识水平，并提高对前列腺癌的认识。2020年12月至2021年1月，在叙利亚大马士革的叙利亚私立大学进行了一项横断面研究。样本包括来自叙利亚私立大学不同院系的所有年级的学生。这些数据是通过问卷调查收集的，以衡量人们对前列腺癌的认识。参与者总数为446人，来自所有院系，包括男性和女性。听说过前列腺癌的学生占73.1%，听说过PSA检测的学生占52%。局部恶性病变，这将为超声引导下的穿刺活检或细针穿刺铺平道路。因此，我们也期待每年用一个月的时间来提高对前列腺恶性肿瘤的认识，增加筛查测试，并支持卫生当局主办的免费检查。通过实现这一目标，我们可能能够宣布我们有一个适当的意识项目来对抗叙利亚的前列腺癌。
{"title":"Awareness of prostate cancer: A research study on Syrian private university students, Syria","authors":"Muhammad Assem Kubtan, Sara Restum, Mazen Alloush","doi":"10.15406/jcpcr.2021.12.00452","DOIUrl":"https://doi.org/10.15406/jcpcr.2021.12.00452","url":null,"abstract":"Prostate cancer is one of the most commonly occurring cancers in men, in 2018 there were 1.3 million new cases, according to a study conducted by the American Institute for Cancer Research, resulting in a significant rate of deaths. Needless to that there is a lack of efforts to make this disease noticeable by public as being made in carcinoma of Breast in women. Our study aims to determine the knowledge level of student at the Syrian Private University concerning as well as raising awareness about prostate cancer. A cross-sectional study was done at the Syrian Private University in Damascus, Syria, between December 2020 until January 2021. The sample included students of all years from different faculties in the Syrian Private University. The data was collected by a questionnaire to measure the awareness of prostate cancer. The total number of participants was 446, from all faculties including males and females. The number of students who have heard about Prostate Cancer was 73.1%, and the percentage, of those who heard about the PSA Test was 52%. localized malignant lesion and this will pave the way towards performing ultrasound guided needle biopsy or fine needle aspiration . Consequently, we are also looking forward to dedicate a month every year to enhance knowledge of prostatic malignancy, increase screening tests, and support free examinations sponsored by the health authority. By achieving this target we may be able to declare that we have a proper awareness program to combat prostate cancer in Syria.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83537368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.15406/JCPCR.2020.11.00444
Lamyae Nouiakh, K. Oualla, Imane Ouafki, S. Berrad, H. Erraichi, Y. Dkhissi, L. Amaadour, Z. Benbrahim, S. Arifi, M. Boubou, H. Fatemi, N. Mellas
Background: Primary breast lymphoma is a very rare disease. The diffuse large B cell subtype is the most common histological variety. The clinical presentation is non-specific; it can be similar to that found in breast carcinoma. The diagnosis is only retained after a definitive histological analysis. The management of these lymphomas is no different from that of other localizations. We report the case of primary breast diffuse large B cells lymphoma collected at the medical oncology department of the Hassan II Hospital of Fez in a 32-year-old patient. Through this work, we will discuss the epidemiological, clinical, paraclinical, histological, therapeutic, and prognostic characteristics of these tumors. Case presentation: A 32-year-old woman consulted for a left breast nodule evolving for 3 months. Clinical examination objectified a painless mass of the left breast without inflammatory signs and homolateral axillary adenopathy of 3cm. Mammography and breast ultrasound were performed objectifying three tissue lesions measuring 26mm for the largest in the left breast, associated with homolateral axillary adenopathy. A micro biopsy was performed. Histological analysis showed breast parenchyma largely dissociated by cell proliferation of diffuse architecture with large cells. In immunohistochemistry, tumor cells were positive for the anti-CD20 antibody. An extension assessment with thoracoabdominalcomputed tomographydid not show any secondary localization outside the breast lesions found in the mammography and ultrasound. Chemotherapy with R-CHOP was decided, but the patient refused to be treated for family reasons. Conclusion: Through this work, a case of DLBCL was reported with a review of the literature. In summary, the DLBCL histological subtype is the most frequent form of mammary lymphoma. Consolidation radiotherapy after conventional chemotherapy remains the most reasonable therapeutic modality for the treatment of patients with DLBCL. Large studies are necessary to identify the factors that influence survival, to improve the management of patients with these lymphomas.
{"title":"Diffuse large cell type B breast lymphoma: case report","authors":"Lamyae Nouiakh, K. Oualla, Imane Ouafki, S. Berrad, H. Erraichi, Y. Dkhissi, L. Amaadour, Z. Benbrahim, S. Arifi, M. Boubou, H. Fatemi, N. Mellas","doi":"10.15406/JCPCR.2020.11.00444","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00444","url":null,"abstract":"Background: Primary breast lymphoma is a very rare disease. The diffuse large B cell subtype is the most common histological variety. The clinical presentation is non-specific; it can be similar to that found in breast carcinoma. The diagnosis is only retained after a definitive histological analysis. The management of these lymphomas is no different from that of other localizations. We report the case of primary breast diffuse large B cells lymphoma collected at the medical oncology department of the Hassan II Hospital of Fez in a 32-year-old patient. Through this work, we will discuss the epidemiological, clinical, paraclinical, histological, therapeutic, and prognostic characteristics of these tumors. Case presentation: A 32-year-old woman consulted for a left breast nodule evolving for 3 months. Clinical examination objectified a painless mass of the left breast without inflammatory signs and homolateral axillary adenopathy of 3cm. Mammography and breast ultrasound were performed objectifying three tissue lesions measuring 26mm for the largest in the left breast, associated with homolateral axillary adenopathy. A micro biopsy was performed. Histological analysis showed breast parenchyma largely dissociated by cell proliferation of diffuse architecture with large cells. In immunohistochemistry, tumor cells were positive for the anti-CD20 antibody. An extension assessment with thoracoabdominalcomputed tomographydid not show any secondary localization outside the breast lesions found in the mammography and ultrasound. Chemotherapy with R-CHOP was decided, but the patient refused to be treated for family reasons. Conclusion: Through this work, a case of DLBCL was reported with a review of the literature. In summary, the DLBCL histological subtype is the most frequent form of mammary lymphoma. Consolidation radiotherapy after conventional chemotherapy remains the most reasonable therapeutic modality for the treatment of patients with DLBCL. Large studies are necessary to identify the factors that influence survival, to improve the management of patients with these lymphomas.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"7 Suppl 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82646845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.15406/JCPCR.2020.11.00445
Martynov Vladimir Leonidovich
reflux in most people. The predominance of sensory neurons in the innervation of the ileocecal region indicates that the ileocecal valve is a highly sensitive formation of the human intestine. According to LG Peretz [1975], 1ml of the small intestine contains up to 5000 microbes, and 1g of the contents of the large intestine contains about 30-40 billion. With the loss of the barrier function of the Bauhinia valve, colonization of the small intestine by foreign microbes from another habitat occurs with the development of dysbiosis1 and certain pathological consequences.2 The study of the content of enzymes in the feces of patients with reflux enteritis showed the presence of hyperfermentosis, i.e., an increased content of enterokinase, alkaline phosphatase, as well as bile acids, pancreatic enzymes, and stomach enzymes. This fecal hyperfermentosis is a consequence of incomplete deactivation of intestinal enzymes, deconjugation of primary bile acids. Fecal hyperfermentosis, as well as the presence of primary bile acids in the large intestine, especially in its left half, serves as a trigger for spastic colitis, especially left-sided.3 M. Brotman [348] found that about 95% of bile acids are normally absorbed in the ileum, which re-enter the liver, GG Nemsadze & EP Rybin4 found in a group of 192 patients with colon cancer a significant increase in the excretion of bile acids with the failure of the Bauhinia valve in comparison with its normal function. Indirect data on the possible role of NBZ in increasing the excretion of bile acids were obtained by analyzing the characteristics of the metabolism of bile acids in the enterohepatic cycle.5 Some authors suggest that, through the formation of carcinogenic substances from bile acids, bacteroids may contribute to an increased incidence of colon cancer.6 Other authors7 definitely believe that “the elimination of NBZ and the use of anti reflux anastomosis open up the possibility of surgical prevention of precancerous diseases and colonic cancer.
大多数人都有反流回盲区神经支配的感觉神经元占主导地位，表明回盲瓣是人类肠道的一个高度敏感的结构。根据LG Peretz[1975]的研究，1ml的小肠含有多达5000个微生物，1g的大肠内容物含有约300 - 400亿个微生物。随着紫荆花瓣膜屏障功能的丧失，来自其他栖息地的外来微生物在小肠定植，发生生态失调1和某些病理后果对反流性肠炎患者粪便中酶含量的研究显示存在高发酵症，即肠激酶、碱性磷酸酶以及胆汁酸、胰腺酶和胃酶的含量增加。这种粪便高发酵症是肠道酶不完全失活，原胆汁酸解结的结果。粪性高发酵症，以及大肠(尤其是左半部分)中原发性胆汁酸的存在，是痉挛性结肠炎(尤其是左侧)的诱因M. Brotman[348]发现，在正常情况下，约95%的胆汁酸在回肠被吸收，然后重新进入肝脏，GG Nemsadze & EP Rybin4在192例结肠癌患者中发现，紫荆瓣膜功能衰竭后，胆汁酸的排泄量明显高于其正常功能。通过分析胆汁酸在肠肝循环中的代谢特点，获得了NBZ可能增加胆汁酸排泄的间接数据一些作者认为，通过胆汁酸形成致癌物质，类细菌可能会增加结肠癌的发病率其他作者则肯定地认为，“消除NBZ和使用抗反流吻合器，为手术预防癌前病变和结肠癌开辟了可能性。”
{"title":"Development of the method of surgical correction of insolvency bauginia damper-Experience of 600 operations","authors":"Martynov Vladimir Leonidovich","doi":"10.15406/JCPCR.2020.11.00445","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00445","url":null,"abstract":"reflux in most people. The predominance of sensory neurons in the innervation of the ileocecal region indicates that the ileocecal valve is a highly sensitive formation of the human intestine. According to LG Peretz [1975], 1ml of the small intestine contains up to 5000 microbes, and 1g of the contents of the large intestine contains about 30-40 billion. With the loss of the barrier function of the Bauhinia valve, colonization of the small intestine by foreign microbes from another habitat occurs with the development of dysbiosis1 and certain pathological consequences.2 The study of the content of enzymes in the feces of patients with reflux enteritis showed the presence of hyperfermentosis, i.e., an increased content of enterokinase, alkaline phosphatase, as well as bile acids, pancreatic enzymes, and stomach enzymes. This fecal hyperfermentosis is a consequence of incomplete deactivation of intestinal enzymes, deconjugation of primary bile acids. Fecal hyperfermentosis, as well as the presence of primary bile acids in the large intestine, especially in its left half, serves as a trigger for spastic colitis, especially left-sided.3 M. Brotman [348] found that about 95% of bile acids are normally absorbed in the ileum, which re-enter the liver, GG Nemsadze & EP Rybin4 found in a group of 192 patients with colon cancer a significant increase in the excretion of bile acids with the failure of the Bauhinia valve in comparison with its normal function. Indirect data on the possible role of NBZ in increasing the excretion of bile acids were obtained by analyzing the characteristics of the metabolism of bile acids in the enterohepatic cycle.5 Some authors suggest that, through the formation of carcinogenic substances from bile acids, bacteroids may contribute to an increased incidence of colon cancer.6 Other authors7 definitely believe that “the elimination of NBZ and the use of anti reflux anastomosis open up the possibility of surgical prevention of precancerous diseases and colonic cancer.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82881318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.15406/jcpcr.2020.11.00446
Filali N, E. S, Daoudi S, Abahssain H, Bechar H, E. H
{"title":"Ifosfamide-induced encephalopathy: about 15 cases and review of the literature","authors":"Filali N, E. S, Daoudi S, Abahssain H, Bechar H, E. H","doi":"10.15406/jcpcr.2020.11.00446","DOIUrl":"https://doi.org/10.15406/jcpcr.2020.11.00446","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74035380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-28DOI: 10.15406/JCPCR.2020.11.00443
Irfan M Lone
{"title":"Impact of cancer diagnosis on emotional well-being and quality of life on LGBT population in India and across Europe; A report drawn on the bases of experience and bird’s eye view of a psycho-oncologist","authors":"Irfan M Lone","doi":"10.15406/JCPCR.2020.11.00443","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00443","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86167781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.15406/JCPCR.2020.11.00442
A. Lushnikova, G. Smirnova, A. V. Kostarev, A. V. Onyan, A. A. Rudakova, K. Kozhikhova, S. M. Andreev
Background: Metastatic cutaneous melanoma is the most aggressive skin cancer with poor prognosis. As a rule, metastatic melanoma tumors with various localization have not complete recovery. Effective therapy of disseminated cutaneous melanoma remains an acute problem, in spite of the recent advances in immunotherapy and targeted molecular therapy. This paper describes a preliminary data obtained from the analysis of cytotoxicity and antitumor activity of some cationic peptides (CPs), in metastatic cutaneous melanoma cell lines generated from the biopsies and subcutaneous cutaneous melanoma xenografts in immunodeficient mice. Molecular mechanisms for CP selective cytotoxicity and specific antitumor effect are related with functional inhibition of chaperone proteins nucleolin and nucleophosmin followed by nucleolar stress. Objective: Evaluation of cytotoxicity and antitumor activities of some cationic peptides using in vitro and in vivo cell and mice xenograft models. Material and methods: Three cutaneus melanoma cell lines generated from metastatic lymph nodes were used for in vitro analysis of cytotoxicity of 4 cationic peptides by MTT assay. Antitumor activity of the peptides was studied in vivo using subcutaneous xenografts generated from MelCher melanoma cell line. Flow cytometry and molecular docking were used for analysis of molecular mechanisms of cell death induced by peptides under study. Results: The use of cationic peptides (CPs) with specific molecular structure for inducing selective tumor cell death, namely cutaneous melanoma, seems to solve a problem of melanoma resistance to standard treatment. Suchcationic dendritic peptides: have some advantages (1) low toxicity fornormal cells, (2) rapid penetration through cell membranes, (3) the interaction with specific surface and intracellular targets in tumor cells, including, cell surface nucleolin (NCL). This chaperone protein is highly expressed in solid tumors and trigger ligand internalization, including cationic peptides. Nucleolin and nucleophosmin (NPM) control the most important cell functions - DNA transcription, RNA translation, ribosome biogenesis, chromatin remodeling, cell signaling, differentiation, invasion, angiogenesis and carcinogenesis. However, NCL/NPM expression in normal tissues is significantly lower. Differential expression levels of NCL and NPM in tumor and normal cells allows to use these proteins as a targets for selective inhibition of tumor growth. Molecular mechanisms for CP selective cytotoxicity and specific antitumor effect are related with functional inhibition of NCL/NPM followed by nucleolar stress this idea was proven by in vivo experiments using melChermice subcutaneous xenografts. Conclusion: Tumor growth suppression up to 85% was induced by two tested cationic peptides (CPs) in MelCher xenografts. High selective cytotoxicity of PCs tested for three cutaneous melanoma cell lines was also revealed invitro . Molecular docking results indicate high poss
{"title":"Perspective approach for cutaneous melanoma treatment by cationic peptides","authors":"A. Lushnikova, G. Smirnova, A. V. Kostarev, A. V. Onyan, A. A. Rudakova, K. Kozhikhova, S. M. Andreev","doi":"10.15406/JCPCR.2020.11.00442","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00442","url":null,"abstract":"Background: Metastatic cutaneous melanoma is the most aggressive skin cancer with poor prognosis. As a rule, metastatic melanoma tumors with various localization have not complete recovery. Effective therapy of disseminated cutaneous melanoma remains an acute problem, in spite of the recent advances in immunotherapy and targeted molecular therapy. This paper describes a preliminary data obtained from the analysis of cytotoxicity and antitumor activity of some cationic peptides (CPs), in metastatic cutaneous melanoma cell lines generated from the biopsies and subcutaneous cutaneous melanoma xenografts in immunodeficient mice. Molecular mechanisms for CP selective cytotoxicity and specific antitumor effect are related with functional inhibition of chaperone proteins nucleolin and nucleophosmin followed by nucleolar stress. Objective: Evaluation of cytotoxicity and antitumor activities of some cationic peptides using in vitro and in vivo cell and mice xenograft models. Material and methods: Three cutaneus melanoma cell lines generated from metastatic lymph nodes were used for in vitro analysis of cytotoxicity of 4 cationic peptides by MTT assay. Antitumor activity of the peptides was studied in vivo using subcutaneous xenografts generated from MelCher melanoma cell line. Flow cytometry and molecular docking were used for analysis of molecular mechanisms of cell death induced by peptides under study. Results: The use of cationic peptides (CPs) with specific molecular structure for inducing selective tumor cell death, namely cutaneous melanoma, seems to solve a problem of melanoma resistance to standard treatment. Suchcationic dendritic peptides: have some advantages (1) low toxicity fornormal cells, (2) rapid penetration through cell membranes, (3) the interaction with specific surface and intracellular targets in tumor cells, including, cell surface nucleolin (NCL). This chaperone protein is highly expressed in solid tumors and trigger ligand internalization, including cationic peptides. Nucleolin and nucleophosmin (NPM) control the most important cell functions - DNA transcription, RNA translation, ribosome biogenesis, chromatin remodeling, cell signaling, differentiation, invasion, angiogenesis and carcinogenesis. However, NCL/NPM expression in normal tissues is significantly lower. Differential expression levels of NCL and NPM in tumor and normal cells allows to use these proteins as a targets for selective inhibition of tumor growth. Molecular mechanisms for CP selective cytotoxicity and specific antitumor effect are related with functional inhibition of NCL/NPM followed by nucleolar stress this idea was proven by in vivo experiments using melChermice subcutaneous xenografts. Conclusion: Tumor growth suppression up to 85% was induced by two tested cationic peptides (CPs) in MelCher xenografts. High selective cytotoxicity of PCs tested for three cutaneous melanoma cell lines was also revealed invitro . Molecular docking results indicate high poss","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"167 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78532989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.15406/JCPCR.2020.11.00440
H. Jaafar, Ahmed Mohieldin, R. Mohsen, A. Farsi, Aladdin Maarraou, Muath Al-Nassar, Trad Diaeddine, Dalia El Shourbagy, E. Dawoud
EGFR mutations commonly occur in exon 19 or 21 (approximately 45 and 40% of patients, respectively) in NSCLC patients that activate the tyrosine kinase domain in epidermal growth factor receptors.5 As EGFR mutational status is critical in the management of advanced stage lung cancer, early EGFR testing has gained importance over time so as to provide timely and personalized treatment therapies to such patients.6 National Comprehensive Cancer Network (NCCN) guidelines recommend the use of EGFR tyrosine kinase inhibitors (TKIs) (gefitinib, erlotinib, afatinib, osimertinib and dacomitinib) as the first line agents for the treatments of EGFR positive NSCLC patients.7 TKIs have demonstrated improved progression-free survival (PFS), higher response rates, better overall quality of life, and fewer side effects in comparison to standard platinum-based chemotherapy.8–10 However, disease progression secondary to acquired resistance to TKI treatment (after a median of 10-14 months), occurred in up to 60% of patients due to acquired T790M mutations11 while primary T790M mutations are very rare.12
{"title":"Epidermal growth factor receptor (EGFR) positive non-small-cell lung carcinoma (NSCLC) patients in the Gulf region: current status, challenges, and call for action","authors":"H. Jaafar, Ahmed Mohieldin, R. Mohsen, A. Farsi, Aladdin Maarraou, Muath Al-Nassar, Trad Diaeddine, Dalia El Shourbagy, E. Dawoud","doi":"10.15406/JCPCR.2020.11.00440","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00440","url":null,"abstract":"EGFR mutations commonly occur in exon 19 or 21 (approximately 45 and 40% of patients, respectively) in NSCLC patients that activate the tyrosine kinase domain in epidermal growth factor receptors.5 As EGFR mutational status is critical in the management of advanced stage lung cancer, early EGFR testing has gained importance over time so as to provide timely and personalized treatment therapies to such patients.6 National Comprehensive Cancer Network (NCCN) guidelines recommend the use of EGFR tyrosine kinase inhibitors (TKIs) (gefitinib, erlotinib, afatinib, osimertinib and dacomitinib) as the first line agents for the treatments of EGFR positive NSCLC patients.7 TKIs have demonstrated improved progression-free survival (PFS), higher response rates, better overall quality of life, and fewer side effects in comparison to standard platinum-based chemotherapy.8–10 However, disease progression secondary to acquired resistance to TKI treatment (after a median of 10-14 months), occurred in up to 60% of patients due to acquired T790M mutations11 while primary T790M mutations are very rare.12","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86446754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.15406/JCPCR.2020.11.00441
H. Anis
Stratifying by sex from male and female CRC, for the highest vs. lowest categories of WC level, were 1.38 (95% CI, 1.19-1.59) and 1.44 (95% CI, 1.28-1.61) respectively. By geographic region, the pooled RRs of CRC for the highest vs. lowest categories of WC level were 1.31 for Asia, 1.50 in the United States, and 1.29 for Europe. Meta-regression analysis showed that geographic region was the source of heterogeneity.1,3
{"title":"Colorectal cancer risk associated with abdominal obesity. data review","authors":"H. Anis","doi":"10.15406/JCPCR.2020.11.00441","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00441","url":null,"abstract":"Stratifying by sex from male and female CRC, for the highest vs. lowest categories of WC level, were 1.38 (95% CI, 1.19-1.59) and 1.44 (95% CI, 1.28-1.61) respectively. By geographic region, the pooled RRs of CRC for the highest vs. lowest categories of WC level were 1.31 for Asia, 1.50 in the United States, and 1.29 for Europe. Meta-regression analysis showed that geographic region was the source of heterogeneity.1,3","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85746054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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