Pub Date : 2021-09-30DOI: 10.18231/j.joapr.2021.v9.i3.1-7
D. Pradhan, Prodipta Chakraborty, Sudip Halder, A. Bagchi
{"title":"An overview on FDA-approved natural super disintegrants efficacy in a fast dissolving drug delivery system","authors":"D. Pradhan, Prodipta Chakraborty, Sudip Halder, A. Bagchi","doi":"10.18231/j.joapr.2021.v9.i3.1-7","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.v9.i3.1-7","url":null,"abstract":"","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75719539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation process of EDTA for infusion/ injection with ceftriaxone and sulbactam","authors":"Md. Semimul Akhtar, Akash Babu, Sudip Kumar Mandal","doi":"10.18231/j.joapr.2021.v9.i3.39-47","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.v9.i3.39-47","url":null,"abstract":"ABSTRACT","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"586 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77816515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.18231/j.joapr.2021.v9.i3.14-20
Priya Kushwah, Pravin Kumar Sharma, Sweta S Koka, A. Gupta, Ravi Sharma, G. Darwhekar
{"title":"Microemulgel: a novel approach for topical drug delivery","authors":"Priya Kushwah, Pravin Kumar Sharma, Sweta S Koka, A. Gupta, Ravi Sharma, G. Darwhekar","doi":"10.18231/j.joapr.2021.v9.i3.14-20","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.v9.i3.14-20","url":null,"abstract":"","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81656156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.18231/j.joapr.2021.v9.i3.26-38
T. Uwah, E. I. Akpabio, D. Effiong
{"title":"Plants as pharmaceutical excipients in oral sustained drug delivery systems: A review","authors":"T. Uwah, E. I. Akpabio, D. Effiong","doi":"10.18231/j.joapr.2021.v9.i3.26-38","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.v9.i3.26-38","url":null,"abstract":"","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"29 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80373684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-15DOI: 10.18231/j.joapr.2021.25.29
Shoaeba Shaikh, S. Desai, H. Jain, A. Sahu, D. Meshram
{"title":"Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate","authors":"Shoaeba Shaikh, S. Desai, H. Jain, A. Sahu, D. Meshram","doi":"10.18231/j.joapr.2021.25.29","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.25.29","url":null,"abstract":"","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81030338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18231/j.joapr.2021.10.14
S. Das, M. Kuddus, N. Qais, C. M. Hasan
Clerodendrum viscosum Vent. is a very common plant in Bangladesh which is locally familiar as “Bhat” or “Ghetu”. Here, the ethanol extract of whole plant part of C. viscosum and its various solvent (petroleum-ether, chloroform and ethyl acetate) fractions were subjected for the appraisal of analgesic, antioxidant and cytotoxic activities. Analgesic activity was tested by acetic acid-induced writhing model in Swiss albino mice. All the plant samples at the oral doses of 100- and 200 mg/kg body weight were found to exhibit significant (p<0.05) pain reducing activity in test animals. Highest inhibition of writhing was 62.38% by the ethyl acetate soluble fraction at dose of 200 mg/kg body weight while the standard drug diclofenac sodium (50 mg/kg) produces 76.14% reduction of abdominal writhing. DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical quenching assay was employed to determine the antioxidant potential of the plant samples while cytotoxic activity was checked by brine shrimp lethality bioassay. In DPPH radical scavenging assay, the plant samples showed prominent antioxidant activity. Among all, the ethyl acetate fraction showed maximum antioxidant potential with IC50 value of 28.02±0.53 μg/ml. In cytotoxic assay, the petroleum-ether fraction demonstrated strong cytotoxicity with LC50 value of 1.42±1.12 μg/ml. In summary, C. viscosum extracts possess significant analgesic, antioxidant and cytotoxic activities which rationalize its traditional use in folk medicine.
{"title":"Evaluation of analgesic, antioxidant and cytotoxic activities of ethanol extract of Clerodendrum viscosum Vent","authors":"S. Das, M. Kuddus, N. Qais, C. M. Hasan","doi":"10.18231/j.joapr.2021.10.14","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.10.14","url":null,"abstract":"Clerodendrum viscosum Vent. is a very common plant in Bangladesh which is locally familiar as “Bhat” or “Ghetu”. Here, the ethanol extract of whole plant part of C. viscosum and its various solvent (petroleum-ether, chloroform and ethyl acetate) fractions were subjected for the appraisal of analgesic, antioxidant and cytotoxic activities. Analgesic activity was tested by acetic acid-induced writhing model in Swiss albino mice. All the plant samples at the oral doses of 100- and 200 mg/kg body weight were found to exhibit significant (p<0.05) pain reducing activity in test animals. Highest inhibition of writhing was 62.38% by the ethyl acetate soluble fraction at dose of 200 mg/kg body weight while the standard drug diclofenac sodium (50 mg/kg) produces 76.14% reduction of abdominal writhing. DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical quenching assay was employed to determine the antioxidant potential of the plant samples while cytotoxic activity was checked by brine shrimp lethality bioassay. In DPPH radical scavenging assay, the plant samples showed prominent antioxidant activity. Among all, the ethyl acetate fraction showed maximum antioxidant potential with IC50 value of 28.02±0.53 μg/ml. In cytotoxic assay, the petroleum-ether fraction demonstrated strong cytotoxicity with LC50 value of 1.42±1.12 μg/ml. In summary, C. viscosum extracts possess significant analgesic, antioxidant and cytotoxic activities which rationalize its traditional use in folk medicine.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80958302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18231/j.joapr.2021.01.05
A. Bagchi, Prosanta Pal
The aim of the current review is to acquaint all the covering aspect of dibetes mellitus which can provide awareness to the diabetes patients in india as well as all over the world. The number of diabetic patients in india is increasing at an alarming rate and is therefore a major area for concern. As per the WHO, the diabetes is expected to reach 79.4 million by 2030. The studies have shown that the type II diabetes is 4-6 times higher in urban than in rural areas in india. Development of diabetes among indians is due to several factors such as age ( Based on NHANES data),waist circumference, hypertention, BMI, smoking habit and total cholestero these variables are important for comparing diabetic and non-diabetic patients
{"title":"In India, diabetes mellitus is on the rise at an alarming rate: A review","authors":"A. Bagchi, Prosanta Pal","doi":"10.18231/j.joapr.2021.01.05","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.01.05","url":null,"abstract":"The aim of the current review is to acquaint all the covering aspect of dibetes mellitus which can provide awareness to the diabetes patients in india as well as all over the world. The number of diabetic patients in india is increasing at an alarming rate and is therefore a major area for concern. As per the WHO, the diabetes is expected to reach 79.4 million by 2030. The studies have shown that the type II diabetes is 4-6 times higher in urban than in rural areas in india. Development of diabetes among indians is due to several factors such as age ( Based on NHANES data),waist circumference, hypertention, BMI, smoking habit and total cholestero these variables are important for comparing diabetic and non-diabetic patients","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87289527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18231/j.joapr.2021.06.09
Sudip Halder, Prodipta Chakraborty, D. Pradhan, A. Bagchi
A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The transdermal drug delivery system (TDDS) provides an alternative safe means of drug delivery to previous intrusive techniques. In the past, topically applied lotions and ointments were the most commonly utilised systems for dermatological issues. The fact that some of these formulations cause systemic side effects indicates that they are absorbed through the skin. All topically applied medication formulations intended to transport the active ingredient into the general circulation are included in the transdermal delivery system. To overcome the skin's formidable barrier to topical medication administration, several substances have been utilised. Because of their unique qualities, such as improved bioavailability, regulated pharmaceutical release, and improved patient compliance, TDDS have recently gained increased attention. The current review focuses on the various advancements in transdermal drug delivery, as well as the various available methods for preparing transdermal patches, characterization and assessment tools for transdermal patch preparation, patents, transdermal compound clinical trials, and drug approved and future applications of transdermal drug delivery systems. As a result, in recent years, the Transdermal Drug Delivery System has received a lot of attention.
{"title":"Recent advancement in the method of transdermal drug delivery system: A review","authors":"Sudip Halder, Prodipta Chakraborty, D. Pradhan, A. Bagchi","doi":"10.18231/j.joapr.2021.06.09","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.06.09","url":null,"abstract":"A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The transdermal drug delivery system (TDDS) provides an alternative safe means of drug delivery to previous intrusive techniques. In the past, topically applied lotions and ointments were the most commonly utilised systems for dermatological issues. The fact that some of these formulations cause systemic side effects indicates that they are absorbed through the skin. All topically applied medication formulations intended to transport the active ingredient into the general circulation are included in the transdermal delivery system. To overcome the skin's formidable barrier to topical medication administration, several substances have been utilised. Because of their unique qualities, such as improved bioavailability, regulated pharmaceutical release, and improved patient compliance, TDDS have recently gained increased attention. The current review focuses on the various advancements in transdermal drug delivery, as well as the various available methods for preparing transdermal patches, characterization and assessment tools for transdermal patch preparation, patents, transdermal compound clinical trials, and drug approved and future applications of transdermal drug delivery systems. As a result, in recent years, the Transdermal Drug Delivery System has received a lot of attention.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90256320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18231/j.joapr.2021.15.24
R. Padmavathi, K. Keerthana, A. Shanmuga Sundaram Devi, Y. Hari, A. Samad
Objective: The present study planned to study the combined effect of Bromelain and Turmeric in acetic acid induced ulcerative colitis in Wistar rats. Methodology: Wistar rats of either sex (n = 30) were divided into 5 groups. Group – I, Sham control, administered single dose of vehicle rectally; Group –II, colitis control, colitis was induced by rectal administration of single dose of 2 ml of 3%, v/v of acetic acid in 0.9% saline; Group–III, treated with Turmeric (50 mg/kg/p.o); Group–IV, treated with Bromelain (100 mg/kg/p.o) and Group –V, treated with both Turmeric (50 mg/kg/p.o) and Bromelain (100 mg /kg/p.o). Colitis was induced in all the treatment groups on first day and drug treatment was continued for 7 days. During the treatment period, Disease Activity Index (DAI) was assessed daily and on 8th day White Blood Cell (WBC) Count and Differential Leucocyte Count (DLC) was performed and on 9th day all the rats were sacrificed for the assessment of intestinal inflammation, colon myeloperoxidase (MPO) levels and Histopathology. Results obtained were analysed by one-way analysis of variance followed by Tukey’s multiple comparison test. Results: Overall changes in DAI, Inflammatory scores, WBC, DLC and MPO has shown significant improvement with Turmeric and Bromelain compared to Colitis control. However, the combined therapy has shown to be more effective in alleviating ulcerative colitis compared to individual therapies. Conclusion: The present study recommends that the combination of Turmeric and Bromelain has synergistic effect in treating ulcerative colitis.
目的:研究菠萝蛋白酶和姜黄对醋酸致Wistar大鼠溃疡性结肠炎的联合治疗作用。方法:Wistar大鼠各30只，随机分为5组。ⅰ组，假手术对照组，单次给药;-II组，结肠炎对照组，结肠结肠炎是在0.9%生理盐水中单次给药2 ml 3% v/v醋酸;第三组，用姜黄处理(50 mg/kg/p.o);iv组，用菠萝蛋白酶(100 mg/kg/p.o)处理;v组，用姜黄(50 mg/kg/p.o)和菠萝蛋白酶(100 mg/kg/p.o)处理。各治疗组第1天均发生结肠炎，连续用药7 d。治疗期间每日测定疾病活动指数(DAI)，第8天测定白细胞(WBC)计数和白细胞差异计数(DLC)，第9天处死各组大鼠，观察肠道炎症、结肠髓过氧化物酶(MPO)水平和组织病理学变化。所得结果采用单因素方差分析及Tukey多重比较检验进行分析。结果:与结肠炎对照组相比，姜黄和菠萝蛋白酶组DAI、炎症评分、WBC、DLC和MPO的总体变化显示出显著改善。然而，与单独治疗相比，联合治疗在缓解溃疡性结肠炎方面更有效。结论:本研究提示姜黄与菠萝蛋白酶联合治疗溃疡性结肠炎具有协同作用。
{"title":"Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats","authors":"R. Padmavathi, K. Keerthana, A. Shanmuga Sundaram Devi, Y. Hari, A. Samad","doi":"10.18231/j.joapr.2021.15.24","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.15.24","url":null,"abstract":"Objective: The present study planned to study the combined effect of Bromelain and Turmeric in acetic acid induced ulcerative colitis in Wistar rats. \u0000Methodology: Wistar rats of either sex (n = 30) were divided into 5 groups. Group – I, Sham control, administered single dose of vehicle rectally; Group –II, colitis control, colitis was induced by rectal administration of single dose of 2 ml of 3%, v/v of acetic acid in 0.9% saline; Group–III, treated with Turmeric (50 mg/kg/p.o); Group–IV, treated with Bromelain (100 mg/kg/p.o) and Group –V, treated with both Turmeric (50 mg/kg/p.o) and Bromelain (100 mg /kg/p.o). Colitis was induced in all the treatment groups on first day and drug treatment was continued for 7 days. During the treatment period, Disease Activity Index (DAI) was assessed daily and on 8th day White Blood Cell (WBC) Count and Differential Leucocyte Count (DLC) was performed and on 9th day all the rats were sacrificed for the assessment of intestinal inflammation, colon myeloperoxidase (MPO) levels and Histopathology. Results obtained were analysed by one-way analysis of variance followed by Tukey’s multiple comparison test. \u0000Results: Overall changes in DAI, Inflammatory scores, WBC, DLC and MPO has shown significant improvement with Turmeric and Bromelain compared to Colitis control. However, the combined therapy has shown to be more effective in alleviating ulcerative colitis compared to individual therapies. \u0000Conclusion: The present study recommends that the combination of Turmeric and Bromelain has synergistic effect in treating ulcerative colitis.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74472686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-28DOI: 10.18231/joapr.2021.9.1.25.29
Ramen Kalita, K. Bhattacharya, Amir Ali, S. Sandilya
Antioxidants are substances that can prevent cells from the damage caused by unstable molecules such as free radicals. Quercetin, a plant pigment present in many fruits, vegetables, grains, and one of the most beneficial antioxidants in the diet and plays an important role in helping the body and prevent free radical damage, which is linked to chronic diseases. The antioxidant properties of quercetin may help to reduce inflammation, allergy symptoms, blood pressure. A lot of studies have been done and experiments have been conducted both in vivo and in vitro and it has been found that in cultured cells many respiratory viruses were inhibited by quercetin. At a minimal inhibitory concentration of 0.03 to 0.5μg/ml in WI-38 or Hela cells, Cytopathic effects produced by echovirus type 7,11,12,19, rhinovirus, poliovirus, and coxsackievirus A21 and B1 were inhibited. The plaque formed by DNA and RNA viruses such as Herpes Simplex Virus-1, Polio type 1, and parainfluenza types 3 were effectively reduced demonstrating its anti-replicative properties. This article reviews effect of quercetin on different types of viral infections.
{"title":"Quercitin as an antiviral weapon-A review","authors":"Ramen Kalita, K. Bhattacharya, Amir Ali, S. Sandilya","doi":"10.18231/joapr.2021.9.1.25.29","DOIUrl":"https://doi.org/10.18231/joapr.2021.9.1.25.29","url":null,"abstract":"Antioxidants are substances that can prevent cells from the damage caused by unstable molecules such as free radicals. Quercetin, a plant pigment present in many fruits, vegetables, grains, and one of the most beneficial antioxidants in the diet and plays an important role in helping the body and prevent free radical damage, which is linked to chronic diseases. The antioxidant properties of quercetin may help to reduce inflammation, allergy symptoms, blood pressure. A lot of studies have been done and experiments have been conducted both in vivo and in vitro and it has been found that in cultured cells many respiratory viruses were inhibited by quercetin. At a minimal inhibitory concentration of 0.03 to 0.5μg/ml in WI-38 or Hela cells, Cytopathic effects produced by echovirus type 7,11,12,19, rhinovirus, poliovirus, and coxsackievirus A21 and B1 were inhibited. The plaque formed by DNA and RNA viruses such as Herpes Simplex Virus-1, Polio type 1, and parainfluenza types 3 were effectively reduced demonstrating its anti-replicative properties. This article reviews effect of quercetin on different types of viral infections.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86601680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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