Pub Date : 2022-03-31DOI: 10.18231/j.joapr.2022.15.20
S. M., Aakash R, M. A, P. C.
ABSTRACT
摘要
{"title":"Evaluation of wound healing effect of colostrum and curcumin cream in rat excision wound model","authors":"S. M., Aakash R, M. A, P. C.","doi":"10.18231/j.joapr.2022.15.20","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.15.20","url":null,"abstract":"ABSTRACT","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87300687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.18231/j.joapr.2020.29.37
Sabah A. A. Mohamad, S. Shantier, E. A. Garelnabi
{"title":"Microwave-assisted single-step synthesis of acid hydrazides from corresponding acids utilizing newly designed apparatus","authors":"Sabah A. A. Mohamad, S. Shantier, E. A. Garelnabi","doi":"10.18231/j.joapr.2020.29.37","DOIUrl":"https://doi.org/10.18231/j.joapr.2020.29.37","url":null,"abstract":"","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"156 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77891413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.18231/j.joapr.2021.16.22
Moumita Paul, Priyanka Ranabhat, Deepika Khatiwara, A. Bagchi
The goal is to create medicinally beneficial chocolate that has no negative side effects. Carob (Ceratonia siliqua), a basic ingredient in many chocolate formulations, was substituted for cocoa since it requires a large amount of sugar in the formulation and includes caffeine, which stimulates the CNS. Carob is high in natural sweeteners, has no fat, caffeine, or oxalates, and is high in antioxidants, which assist to prevent a variety of ailments. Many traditional drug delivery systems are ineffective for paediatric patients because their developmental state and dosing requirements differ from those of other groups of people. Age-appropriate medicines require technological platforms to ensure patient acceptability while maintaining safety, efficacy, accessibility, and affordability. Recent methods and accomplishments in the field of age-appropriate drug delivery for paediatric patients are discussed, including patient-centric formulations, administration devices, and packaging solutions.
{"title":"Review on medicated chocolate takes a patient-centered approach to drug delivery","authors":"Moumita Paul, Priyanka Ranabhat, Deepika Khatiwara, A. Bagchi","doi":"10.18231/j.joapr.2021.16.22","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.16.22","url":null,"abstract":"The goal is to create medicinally beneficial chocolate that has no negative side effects. Carob (Ceratonia siliqua), a basic ingredient in many chocolate formulations, was substituted for cocoa since it requires a large amount of sugar in the formulation and includes caffeine, which stimulates the CNS. Carob is high in natural sweeteners, has no fat, caffeine, or oxalates, and is high in antioxidants, which assist to prevent a variety of ailments. Many traditional drug delivery systems are ineffective for paediatric patients because their developmental state and dosing requirements differ from those of other groups of people. Age-appropriate medicines require technological platforms to ensure patient acceptability while maintaining safety, efficacy, accessibility, and affordability. Recent methods and accomplishments in the field of age-appropriate drug delivery for paediatric patients are discussed, including patient-centric formulations, administration devices, and packaging solutions.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82490973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.18231/j.joapr.2021.23.28
Priyanka Ranabhat, Deepika Khatiwara, Moumita Paul, A. Bagchi
Because of the COVID 19 pandemic, we now utilise hand sanitizer in our daily lives. Hand hygiene has become a legal requirement. Infection control is becoming a requirement. Hand hygiene is widely regarded as the most practical and effective way of infection prevention. Hand sanitizer is thought to have played a significant role in reducing illness transmission to patients. Because it is more cost-effective and efficient. The efficiency of hand sanitizer is totally determined by how it is used. There are two sorts of hand sanitizers on the market. 1) Hand sanitizer with alcohol 2) Hand sanitizer that isn't alcohol-based. Most effective hand sanitizers contain 70 percent to 95 percent alcohol, which has the potential to denature microbial protein and inactivate viruses. The impact of hand sanitizer on human health care is significant, and this review article will provide you with information on several elements of hand sanitizer
{"title":"A review on using an alcohol-based sanitizer as a prophylactic measure against microorganisms","authors":"Priyanka Ranabhat, Deepika Khatiwara, Moumita Paul, A. Bagchi","doi":"10.18231/j.joapr.2021.23.28","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.23.28","url":null,"abstract":"Because of the COVID 19 pandemic, we now utilise hand sanitizer in our daily lives. Hand hygiene has become a legal requirement. Infection control is becoming a requirement. Hand hygiene is widely regarded as the most practical and effective way of infection prevention. Hand sanitizer is thought to have played a significant role in reducing illness transmission to patients. Because it is more cost-effective and efficient. The efficiency of hand sanitizer is totally determined by how it is used. There are two sorts of hand sanitizers on the market. 1) Hand sanitizer with alcohol 2) Hand sanitizer that isn't alcohol-based. Most effective hand sanitizers contain 70 percent to 95 percent alcohol, which has the potential to denature microbial protein and inactivate viruses. The impact of hand sanitizer on human health care is significant, and this review article will provide you with information on several elements of hand sanitizer","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76367053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.18231/j.joapr.2021.9.15
Soumyadip Ghosh, S. Majumdar, Debgopal Ganguly
Drug delivery to the colonic region refers to the drug that should have to released in the colonic environment instead of released in the upper gastrointestinal tract. To reach the site-specificity of the local treatment of the colon such as amoebiasis, colorectal cancer, and inflammatory bowel disease the target-specific drug delivery played an important role. To the establishment of the target-specific drug delivery to the colon, the various approach that has been explored include pH-dependent polymer, time-dependent, and bacteria-dependent drug delivery approach. Nanotechnology has been gaining much more interest due to target specificity and enhancement of bioavailability and high loading capacity. In this review, oral nanoparticle formulation for colon targeting specifically inflammatory bowel disease and suitable drugs for useful treatment and future aspects of nanoparticle formulation with particular approaches to enhancement of drug stability in the gastric environment have been covered.
{"title":"A brief review on colon-specific drug delivery system for targeting to colonic region","authors":"Soumyadip Ghosh, S. Majumdar, Debgopal Ganguly","doi":"10.18231/j.joapr.2021.9.15","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.9.15","url":null,"abstract":"Drug delivery to the colonic region refers to the drug that should have to released in the colonic environment instead of released in the upper gastrointestinal tract. To reach the site-specificity of the local treatment of the colon such as amoebiasis, colorectal cancer, and inflammatory bowel disease the target-specific drug delivery played an important role. To the establishment of the target-specific drug delivery to the colon, the various approach that has been explored include pH-dependent polymer, time-dependent, and bacteria-dependent drug delivery approach. Nanotechnology has been gaining much more interest due to target specificity and enhancement of bioavailability and high loading capacity. In this review, oral nanoparticle formulation for colon targeting specifically inflammatory bowel disease and suitable drugs for useful treatment and future aspects of nanoparticle formulation with particular approaches to enhancement of drug stability in the gastric environment have been covered.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78251464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.18231/j.joapr.2021.29.38
R. Divakar, P. Sugirda, R. Lenin, T. Henry Daniel Raj
We aimed to assess the effect of Vitamin E on hepatic pathology in terms of liver enzymes and ultrasonographic (USG) findings in Non-alcoholic Fatty liver disease (NAFLD) patients. Vitamin E was administered as α-tocopherol for 12 weeks for 60 patients. Baseline and after 12 weeks of Vitamin E therapy values of anthropometric measures, fasting blood glucose, lipid profile were estimated apart from liver enzymes and USG based assessment of liver size and Hamaguchi score. NAFLD fibrosis score (NFS), a predictor of hepatic fibrosis was evaluated pre and post treatment with Vitamin E. Significant statistical difference was noted in the reduction of Triglycerides, Cholesterol, VLDL and LDL both diabetic and non-diabetic population in our study. ALT and AST normalization was observed and the mean reduction were -38.11 (p 0.001) and -22.4 (p 0.001) respectively due to Vitamin E. Mean liver size was also decreased from 16.05 (SD±1.2) to 13.36 (SD±2.0) after 12 weeks of Vitamin E therapy. However, no significant change in NFS score was noted [baseline – 0.248 (SD±0.78) and at the end of treatment – 0.535 (SD±0.87)], indicating morphological changes were not reversed with Vitamin E. No significant difference observed for mean weight, waist circumference, body mass index (BMI), serum albumin, bilirubin and HDL levels as well as platelet count from baseline to end of treatment. Hence, Vitamin E alone would be useful in the treatment of NAFLD patients even with diabetes and irrespective of biopsy status.
{"title":"Effect of vitamin E on non-alcoholic fatty liver disease (NAFLD) in reversing the biochemical and radiological hepatic pathology – an interventional study","authors":"R. Divakar, P. Sugirda, R. Lenin, T. Henry Daniel Raj","doi":"10.18231/j.joapr.2021.29.38","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.29.38","url":null,"abstract":"We aimed to assess the effect of Vitamin E on hepatic pathology in terms of liver enzymes and ultrasonographic (USG) findings in Non-alcoholic Fatty liver disease (NAFLD) patients. Vitamin E was administered as α-tocopherol for 12 weeks for 60 patients. Baseline and after 12 weeks of Vitamin E therapy values of anthropometric measures, fasting blood glucose, lipid profile were estimated apart from liver enzymes and USG based assessment of liver size and Hamaguchi score. NAFLD fibrosis score (NFS), a predictor of hepatic fibrosis was evaluated pre and post treatment with Vitamin E. Significant statistical difference was noted in the reduction of Triglycerides, Cholesterol, VLDL and LDL both diabetic and non-diabetic population in our study. ALT and AST normalization was observed and the mean reduction were -38.11 (p 0.001) and -22.4 (p 0.001) respectively due to Vitamin E. Mean liver size was also decreased from 16.05 (SD±1.2) to 13.36 (SD±2.0) after 12 weeks of Vitamin E therapy. However, no significant change in NFS score was noted [baseline – 0.248 (SD±0.78) and at the end of treatment – 0.535 (SD±0.87)], indicating morphological changes were not reversed with Vitamin E. No significant difference observed for mean weight, waist circumference, body mass index (BMI), serum albumin, bilirubin and HDL levels as well as platelet count from baseline to end of treatment. Hence, Vitamin E alone would be useful in the treatment of NAFLD patients even with diabetes and irrespective of biopsy status.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86314042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.18231/j.joapr.2021.1.8
Deepika Khatiwara, Priyanka Ranabhat, Moumita Paul, A. Bagchi
Many advances in research and technology have been made in the oral route of drug delivery system in recent years. Because of increased patient compliance not only in geriatric and paediatric patients, but also in the general population, the oral channel of drug delivery system- medicated chewing gum has received worldwide recognition throughout the year. Chewing gum can be used as a mobile medication delivery device for both local and systemic drug administration via the oral route. Because of its ease and ability to be administered without water, it is an exceptional drug delivery device for self-medication. The production technique, advantages, disadvantages, factors impacting the release of medicament, assessment parameter, difficulty related with chewing gum manufacture, and future trends have all been examined in this review paper
{"title":"An emerging technique of medicated chewing gum in drug delivery system: a review","authors":"Deepika Khatiwara, Priyanka Ranabhat, Moumita Paul, A. Bagchi","doi":"10.18231/j.joapr.2021.1.8","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.1.8","url":null,"abstract":"Many advances in research and technology have been made in the oral route of drug delivery system in recent years. Because of increased patient compliance not only in geriatric and paediatric patients, but also in the general population, the oral channel of drug delivery system- medicated chewing gum has received worldwide recognition throughout the year. Chewing gum can be used as a mobile medication delivery device for both local and systemic drug administration via the oral route. Because of its ease and ability to be administered without water, it is an exceptional drug delivery device for self-medication. The production technique, advantages, disadvantages, factors impacting the release of medicament, assessment parameter, difficulty related with chewing gum manufacture, and future trends have all been examined in this review paper","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81173800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.18231/j.joapr.2021.v9.i3.21-25
Prodipta Chakraborty, D. Pradhan, Sudip Halder, A. Bagchi
{"title":"Current developments in prevention and treatment of candidiasis: A review","authors":"Prodipta Chakraborty, D. Pradhan, Sudip Halder, A. Bagchi","doi":"10.18231/j.joapr.2021.v9.i3.21-25","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.v9.i3.21-25","url":null,"abstract":"","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76113201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.18231/j.joapr.2021.v9.i3.8-13
Arghya Biswas
{"title":"Rising Indian Clinical Trials Industry and Career Opportunities","authors":"Arghya Biswas","doi":"10.18231/j.joapr.2021.v9.i3.8-13","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.v9.i3.8-13","url":null,"abstract":"","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89895932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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