Pub Date : 2022-12-31DOI: 10.18231/j.joapr.2022.10.4.25.33
K. Chauhan, Vivek Gupta, Sunil Chauhan, Manoj Soni
Background: Tracheal intubation is frequently associated with cardiovascular stress response characterized by hypertension, tachycardia and increased serum concentration of catecholamines and similar phenomenon is also seen during extubation. During Endotracheal extubation increase in sympathoadrenergic activity is caused by epipharyngeal and laryngopharyngeal stimulation. Objective: The aim and objectives of this study are to compare the effect of combination of intravenous (i.v.) diltiazem 0.1 mg/kg and i.v lignocaine 1.0 mg/kg vs intravenous lignocaine alone to attenuate haemodynamic extubation responses and airway reflexes during extubation. Material and method: This study was undertaken with 72 patients belonging to the age group 20–60 years with physical status ASA Classes I and II of either sex. Group A received injection diltiazem 0.1 mg/kg and lignocaine 1 mg/kg. Group B received injection lignocaine 1 mg/kg with normal saline. In this study, the drug dosage was fixed based on the previous studies. Result: The baseline values of heart rate,systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were statistically comparable between the two groups. The heart rate, SBP, DBP, and MAP was significantly high in group A (lignocaine) as compared to group B (diltiazem with lignocaine) at extubation and till 1 min, 3 min, 5 min, and 10 min post extubation (pvalue < 0.05). Conclusion: Combined diltiazem and lignocaine provides more effective prophylaxis than lignocaine alone for attenuating the cardiovascular responses to tracheal extubation
{"title":"Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi","authors":"K. Chauhan, Vivek Gupta, Sunil Chauhan, Manoj Soni","doi":"10.18231/j.joapr.2022.10.4.25.33","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.4.25.33","url":null,"abstract":"\u0000 Background: Tracheal intubation is frequently associated with cardiovascular stress response characterized by hypertension, tachycardia and increased serum concentration of catecholamines and similar phenomenon is also seen during extubation. During Endotracheal extubation increase in sympathoadrenergic activity is caused by epipharyngeal and laryngopharyngeal stimulation. Objective: The aim and objectives of this study are to compare the effect of combination of intravenous (i.v.) diltiazem 0.1 mg/kg and i.v lignocaine 1.0 mg/kg vs intravenous lignocaine alone to attenuate haemodynamic extubation responses and airway reflexes during extubation. Material and method: This study was undertaken with 72 patients belonging to the age group 20–60 years with physical status ASA Classes I and II of either sex. Group A received injection diltiazem 0.1 mg/kg and lignocaine 1 mg/kg. Group B received injection lignocaine 1 mg/kg with normal saline. In this study, the drug dosage was fixed based on the previous studies. Result: The baseline values of heart rate,systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were statistically comparable between the two groups. The heart rate, SBP, DBP, and MAP was significantly high in group A (lignocaine) as compared to group B (diltiazem with lignocaine) at extubation and till 1 min, 3 min, 5 min, and 10 min post extubation (pvalue < 0.05). Conclusion: Combined diltiazem and lignocaine provides more effective prophylaxis than lignocaine alone for attenuating the cardiovascular responses to tracheal extubation\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"343 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89240269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.18231/j.joapr.2022.10.4.19.24
V. Choudhary, C. Choudhary, Ayushi Sharma, V. K. Sharma, P. Saraswat
Objective: To Identify molecular characterization of swine flu (H1N1) pdm 09 and seasonal flu (influenza A). Materials and methods: NP/OP Swab specimen of 142 patients were collected aseptically in VTM. Nucleic Acid was extracted manually and was processed in Real-Time PCR for identification of swine flu (H1N1) 09 pdm and seasonal flu (inf A). Results: In this study, 142 patients presented with signs and symptoms of Flu like illness patients and were tested by Real-time PCR. Out of total 32 (22.53%) positive specimens, 18(56.25%) were positive swine flu(H1N1) 09 pdm and 14(43.73%) were positive seasonal flu (inf A). Conclusion: We report a tiny outbreak of 18 swine flu (H1N1) 09 pdm and 14 seasonal flu cases in our hospital, from Jan 2022 to June 2022. The outbreak involved persons of all age groups, but it mostly affected paediatric age group.
{"title":"Swine flu (H1N1) pandemic strain-09 PDM: A recent outbreak in northern India","authors":"V. Choudhary, C. Choudhary, Ayushi Sharma, V. K. Sharma, P. Saraswat","doi":"10.18231/j.joapr.2022.10.4.19.24","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.4.19.24","url":null,"abstract":"\u0000 Objective: To Identify molecular characterization of swine flu (H1N1) pdm 09 and seasonal flu (influenza A). Materials and methods: NP/OP Swab specimen of 142 patients were collected aseptically in VTM. Nucleic Acid was extracted manually and was processed in Real-Time PCR for identification of swine flu (H1N1) 09 pdm and seasonal flu (inf A). Results: In this study, 142 patients presented with signs and symptoms of Flu like illness patients and were tested by Real-time PCR. Out of total 32 (22.53%) positive specimens, 18(56.25%) were positive swine flu(H1N1) 09 pdm and 14(43.73%) were positive seasonal flu (inf A). Conclusion: We report a tiny outbreak of 18 swine flu (H1N1) 09 pdm and 14 seasonal flu cases in our hospital, from Jan 2022 to June 2022. The outbreak involved persons of all age groups, but it mostly affected paediatric age group.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75064557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.18231/j.joapr.2022.10.4.14.18
Chetali Das, R. Mathur, Srishti Kukreja
Background: Ultrasonography-assisted supraclavicular block is an efficacious and practical method and allows us to use a lower volume of local anesthetic in compactly arranged brachial plexus. The study envisioned evaluating the analgesic and anesthetic effects of Inj. dexamethasone (8mg) as an adjuvant to 0.5% levobupivacaine to determine the time for first rescue analgesia and number of rescue analgesics needed in 24 hours duration in brachial plexus blockade in adult patients listed for upper limb surgeries. Results: This prospective randomized double-blind interventional study was carried out in ASAI and II, aged 20 to 55 years. In group A (n=30) Inj. Levobupivacaine 20ml and Inj. Normal saline 2ml was given. In group B (n=30) Inj. Levobupivacaine 20ml and Inj. Dexamethasone 2ml was given. The time for the demand of the first rescue analgesia was 431.50 ± 46.15 minutes in group A and 749.38 ± 62.41 minutes in group B, with a p-value < 0.001. The demand for rescue analgesics was more in Group A in contrast to Group B. Conclusion: We deduce with our study, with the addition of dexamethasone, the time for rescue analgesia is prolonged, and the number of rescue analgesic demands is reduced, with a faster onset and extended duration of both sensory and motor block.
{"title":"Clinical comparison of analgesic efficacy of addition of injection dexamethasone 8mg to 20ml 0.5% levobupivacaine in ultrasonography assisted supraclavicular brachial plexus block","authors":"Chetali Das, R. Mathur, Srishti Kukreja","doi":"10.18231/j.joapr.2022.10.4.14.18","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.4.14.18","url":null,"abstract":"\u0000 Background: Ultrasonography-assisted supraclavicular block is an efficacious and practical method and allows us to use a lower volume of local anesthetic in compactly arranged brachial plexus. The study envisioned evaluating the analgesic and anesthetic effects of Inj. dexamethasone (8mg) as an adjuvant to 0.5% levobupivacaine to determine the time for first rescue analgesia and number of rescue analgesics needed in 24 hours duration in brachial plexus blockade in adult patients listed for upper limb surgeries. Results: This prospective randomized double-blind interventional study was carried out in ASAI and II, aged 20 to 55 years. In group A (n=30) Inj. Levobupivacaine 20ml and Inj. Normal saline 2ml was given. In group B (n=30) Inj. Levobupivacaine 20ml and Inj. Dexamethasone 2ml was given. The time for the demand of the first rescue analgesia was 431.50 ± 46.15 minutes in group A and 749.38 ± 62.41 minutes in group B, with a p-value < 0.001. The demand for rescue analgesics was more in Group A in contrast to Group B. Conclusion: We deduce with our study, with the addition of dexamethasone, the time for rescue analgesia is prolonged, and the number of rescue analgesic demands is reduced, with a faster onset and extended duration of both sensory and motor block.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82714594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.18231/j.joapr.2022.10.4.38.45
D. Shil, Kishor Kumar Roy, Rasamalla Mounika, M. Reja, S. Saha, Ranjan Kumar Maji
Inflammation is a vital therapeutic target for creating new methods for pharmacological interventions, aside from being a stage in the pathophysiology of many diseases, such as atherosclerosis and rheumatoid arthritis. Thus, molecular understanding of inflammation has led to new opportunities for drug creation and significant new implications for current clinical medicine. It has also revealed the biological targets and mechanisms of therapeutic action, opening up new opportunities to alter complex biological systems. Meanwhile, using medicinal plants to control inflammation has been recommended as an alternative to traditional therapeutic approaches for a variety of conditions, particularly when suppression of inflammation is anticipated. Several medicinal plant species have been demonstrated to have strong anti-inflammatory properties in contemporary research. The review article was discussed about the chemical constituents and biological properties of therapeutically active plants including curcumin from Curcuma longa and epigallocatechin-3-gallate from Camellia sinensis, including the molecular pharmacology of active constituents against inflammation.
{"title":"Medicinal plants use as an anti-inflammatory agent: a brief review on molecular pharmacological approach","authors":"D. Shil, Kishor Kumar Roy, Rasamalla Mounika, M. Reja, S. Saha, Ranjan Kumar Maji","doi":"10.18231/j.joapr.2022.10.4.38.45","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.4.38.45","url":null,"abstract":"\u0000 Inflammation is a vital therapeutic target for creating new methods for pharmacological interventions, aside from being a stage in the pathophysiology of many diseases, such as atherosclerosis and rheumatoid arthritis. Thus, molecular understanding of inflammation has led to new opportunities for drug creation and significant new implications for current clinical medicine. It has also revealed the biological targets and mechanisms of therapeutic action, opening up new opportunities to alter complex biological systems. Meanwhile, using medicinal plants to control inflammation has been recommended as an alternative to traditional therapeutic approaches for a variety of conditions, particularly when suppression of inflammation is anticipated. Several medicinal plant species have been demonstrated to have strong anti-inflammatory properties in contemporary research. The review article was discussed about the chemical constituents and biological properties of therapeutically active plants including curcumin from Curcuma longa and epigallocatechin-3-gallate from Camellia sinensis, including the molecular pharmacology of active constituents against inflammation.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"450 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82966651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.18231/j.joapr.2022.10.4.34.37
Kiwi Mantan, S. Kothari, Shiva Tanwar, Dr. Satyaprakash, J. Baid, G. Joshi
The present study was conducted in Department of Anaesthesia, Sardar Patel Medical College and PBM Hospital, Bikaner, with the aim of comparative evaluation of subclavian vein catheterization by supraclavicular and infraclavicular approach. There are three common routes of central venous catheterization i.e. subclavian, internal jugular and the femoral. Hence in our study we have done a comparative evaluation of supraclavicular and infraclavicular approach for SCV catheterization with primary objective of successful catheterization of SCV using anatomical landmark technique and secondary objective of first attempt success rate, time taken for cannulation and also record the incidence of complications related to either approach. In our study, 60 patients enrolled were randomly divided into two groups of 30 patients each. In Group A Infraclavicular SCV catheterization and in Group B Supraclavicular catheterisation was performed using anatomical landmark approach. Successful catheterization, first attempt success rate, time taken for venous access and catheterization, catheter malfunction or any other complication were recorded. In group A (IC) Maximum 63.33% were inserted in single attempt whereas minimum 10% required 3 or more attempts while in group B (IC) maximum 93.33% were inserted in single attempt whereas minimum 3.33% needed 3 or more attempts, and the difference was found statistically significant. Overall successful catheterization was 90% in Group A and 96% in Group B while 93 % when combined for both groups. Mean time taken for insertion was observed more (6.67 ± 1.44 min.) in group A whereas less (4.47 ± 1.01min.) in group B, and the difference was found statistically highly significant. We conclude that SC approach of SCV catheterization is better as comparable to IC approach in terms of landmarks accessibility, success rate, time taken and rate of complications.
{"title":"Comparative evaluation of subclavian vein catheterization by supraclavicular and infraclavicular approach","authors":"Kiwi Mantan, S. Kothari, Shiva Tanwar, Dr. Satyaprakash, J. Baid, G. Joshi","doi":"10.18231/j.joapr.2022.10.4.34.37","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.4.34.37","url":null,"abstract":"\u0000 The present study was conducted in Department of Anaesthesia, Sardar Patel Medical College and PBM Hospital, Bikaner, with the aim of comparative evaluation of subclavian vein catheterization by supraclavicular and infraclavicular approach. There are three common routes of central venous catheterization i.e. subclavian, internal jugular and the femoral. Hence in our study we have done a comparative evaluation of supraclavicular and infraclavicular approach for SCV catheterization with primary objective of successful catheterization of SCV using anatomical landmark technique and secondary objective of first attempt success rate, time taken for cannulation and also record the incidence of complications related to either approach. In our study, 60 patients enrolled were randomly divided into two groups of 30 patients each. In Group A Infraclavicular SCV catheterization and in Group B Supraclavicular catheterisation was performed using anatomical landmark approach. Successful catheterization, first attempt success rate, time taken for venous access and catheterization, catheter malfunction or any other complication were recorded. In group A (IC) Maximum 63.33% were inserted in single attempt whereas minimum 10% required 3 or more attempts while in group B (IC) maximum 93.33% were inserted in single attempt whereas minimum 3.33% needed 3 or more attempts, and the difference was found statistically significant. Overall successful catheterization was 90% in Group A and 96% in Group B while 93 % when combined for both groups. Mean time taken for insertion was observed more (6.67 ± 1.44 min.) in group A whereas less (4.47 ± 1.01min.) in group B, and the difference was found statistically highly significant. We conclude that SC approach of SCV catheterization is better as comparable to IC approach in terms of landmarks accessibility, success rate, time taken and rate of complications.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83593068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.18231/j.joapr.2022.10.4.1.13
Alaa E. Elawni, Zuheir A. Osman, M. Salih, Waleed Elballa, Mohammed E. A. Shayoub
The objective of this study was to assess the efficacy of several taste-masking techniques and to study the impact of different formulation variables on the physicochemical properties of dispersible tablets containing Ranitidine as a model drug. Ranitidine powder was taste masked using various techniques. Factorial design (24) was applied to design the set of tablet formulations. The four factors implemented were the manufacturing method, filler type, superdisintegrant type and superdisintegrant concentration. Levels selected were direct compression and wet granulation for the manufacturing method, microcrystalline cellulose and mannitol for the diluent type, sodium starch glycolate and croscarmellose sodium for superdisintegrant type, and 2% and 10% for superdisintegrant concentration. Granulation with calcium carbonate (ratio of 1:8) was the taste-masking method of choice to be implemented. The formulated tablets results revealed that the manufacturing method has a significant influence on all the tested physicochemical properties (p-values < 0.05) such as tablet’s weight variation, hardness, friability, and disintegration time. Croscarmellose sodium obtained better results than sodium starch glycolate. Both fillers obtained good properties when implementing direct compression method with croscarmellose sodium concentration of 2%, or wet granulation method with croscarmellose sodium concentration of 10%. Drug release was also increased by increasing concentration of croscarmellose sodium. These findings represent an easy manufacturing procedure with relatively low-cost materials that can be implemented to formulate dispersible tablets of bitter tasting drugs that will enhance patient compliance and lead to faster onset of action.
{"title":"Implementation and comparison of different taste masking techniques to design and assess dispersible tablet formulations","authors":"Alaa E. Elawni, Zuheir A. Osman, M. Salih, Waleed Elballa, Mohammed E. A. Shayoub","doi":"10.18231/j.joapr.2022.10.4.1.13","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.4.1.13","url":null,"abstract":"\u0000 The objective of this study was to assess the efficacy of several taste-masking techniques and to study the impact of different formulation variables on the physicochemical properties of dispersible tablets containing Ranitidine as a model drug. Ranitidine powder was taste masked using various techniques. Factorial design (24) was applied to design the set of tablet formulations. The four factors implemented were the manufacturing method, filler type, superdisintegrant type and superdisintegrant concentration. Levels selected were direct compression and wet granulation for the manufacturing method, microcrystalline cellulose and mannitol for the diluent type, sodium starch glycolate and croscarmellose sodium for superdisintegrant type, and 2% and 10% for superdisintegrant concentration. Granulation with calcium carbonate (ratio of 1:8) was the taste-masking method of choice to be implemented. The formulated tablets results revealed that the manufacturing method has a significant influence on all the tested physicochemical properties (p-values < 0.05) such as tablet’s weight variation, hardness, friability, and disintegration time. Croscarmellose sodium obtained better results than sodium starch glycolate. Both fillers obtained good properties when implementing direct compression method with croscarmellose sodium concentration of 2%, or wet granulation method with croscarmellose sodium concentration of 10%. Drug release was also increased by increasing concentration of croscarmellose sodium. These findings represent an easy manufacturing procedure with relatively low-cost materials that can be implemented to formulate dispersible tablets of bitter tasting drugs that will enhance patient compliance and lead to faster onset of action.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"17 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85563960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.18231/j.joapr.2022.10.3.5.11
Priyanka Prajapat, Dilip Agrawal, Gaurav Bhaduka
The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated dosing. Sustained release drug delivery has a range of advantages over conventional dosage forms, including increased patient compliance due to less frequent drug administration, significantly reduced steady state drug level fluctuations, maximum drug utilization, the increased safety margin of potent drugs, lower healthcare costs due to improved therapy, and shorter treatment times. The present review focuses on design, fabrication, and various factors that influence the performance of sustained-release dosage forms.
{"title":"A brief overview of sustained released drug delivery system","authors":"Priyanka Prajapat, Dilip Agrawal, Gaurav Bhaduka","doi":"10.18231/j.joapr.2022.10.3.5.11","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.3.5.11","url":null,"abstract":"The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated dosing. Sustained release drug delivery has a range of advantages over conventional dosage forms, including increased patient compliance due to less frequent drug administration, significantly reduced steady state drug level fluctuations, maximum drug utilization, the increased safety margin of potent drugs, lower healthcare costs due to improved therapy, and shorter treatment times. The present review focuses on design, fabrication, and various factors that influence the performance of sustained-release dosage forms.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80543512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.18231/j.joapr.2022.10.3.28.38
Shivanand Kolageri, H. S, M. Parit
A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial, treatment. Molecular docking is frequently employed in contemporary drug design to comprehend drug-receptor interaction. Swiss dock, PyRx, and discovery studio visualizer (DSV) tools were used to predict in-silico ADME properties. In the current investigation, substituted benzimidazole-1,3,4-Oxadiazole derivatives were taken for docking studies against 6AYB an Naegleria fowleri CYP51-ketoconazole complex. The main objective of the study is to perform docking of the selected benzimidazole-1,3,4-oxadiazole derivatives on the protein and compare the docking score with standard ketoconazole. The molecular docking study was conducted using PyRx and the discovery studio visualizer (DSV) program, Naegleria fowleri CYP51-ketoconazole complex (6AYB) was obtained from the protein data bank (PDB) site. It was found that the docking score of all sixteen 1,3,4-Oxadiazole compounds ranged from -8.1 to -8.9 Kcal/mol. The novel benzimidazole with 1,3,4-Oxadiazole derivatives has been found to possess antibacterial properties, many substituted 1,3,4-Oxadiazole derivatives have been reported for the activity
一类新型苯并咪唑-1,3,4-恶二唑衍生物是一类重要的杂环分子。在杂环化学中，新型的1,3,4-恶二唑核具有广泛的用途，包括抗菌、治疗等。分子对接在当代药物设计中经常被用于理解药物-受体相互作用。使用Swiss dock, PyRx和discovery studio visualizer (DSV)工具预测硅片ADME性质。本研究采用取代苯并咪唑-1,3,4-恶二唑衍生物对6AYB和福氏奈格氏菌cyp51 -酮康唑配合物进行对接研究。本研究的主要目的是将选定的苯并咪唑-1,3,4-恶二唑衍生物与蛋白质进行对接，并与标准酮康唑进行对接评分比较。利用PyRx和discovery studio visualizer (DSV)程序进行分子对接研究，从蛋白质数据库(PDB)位点获得福氏奈格氏菌cyp51 -酮康唑复合物(6AYB)。结果表明，16个1,3,4-恶二唑类化合物的对接分数在-8.1 ~ -8.9 Kcal/mol之间。具有1,3,4-恶二唑衍生物的新型苯并咪唑已被发现具有抗菌性能，许多取代的1,3,4-恶二唑衍生物已被报道具有抗菌活性
{"title":"In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity","authors":"Shivanand Kolageri, H. S, M. Parit","doi":"10.18231/j.joapr.2022.10.3.28.38","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.3.28.38","url":null,"abstract":"A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial, treatment. Molecular docking is frequently employed in contemporary drug design to comprehend drug-receptor interaction. Swiss dock, PyRx, and discovery studio visualizer (DSV) tools were used to predict in-silico ADME properties. In the current investigation, substituted benzimidazole-1,3,4-Oxadiazole derivatives were taken for docking studies against 6AYB an Naegleria fowleri CYP51-ketoconazole complex. The main objective of the study is to perform docking of the selected benzimidazole-1,3,4-oxadiazole derivatives on the protein and compare the docking score with standard ketoconazole. The molecular docking study was conducted using PyRx and the discovery studio visualizer (DSV) program, Naegleria fowleri CYP51-ketoconazole complex (6AYB) was obtained from the protein data bank (PDB) site. It was found that the docking score of all sixteen 1,3,4-Oxadiazole compounds ranged from -8.1 to -8.9 Kcal/mol. The novel benzimidazole with 1,3,4-Oxadiazole derivatives has been found to possess antibacterial properties, many substituted 1,3,4-Oxadiazole derivatives have been reported for the activity\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78083710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Laparoscopic cholecystectomy has emerged over the open cholecystectomy as gold standard for surgical treatment of symptomatic gall stones. Although pain after laparoscopic cholecystectomy is less intense, but many patients may experience considerable pain during first 24 hours in post-operative period. Intravenous (i.v.) use of dexmedetomidine in perioperative period lead to 90% decrease in the serum catecholamine levels, and further diminishing the haemodynamic response and sedating the patient and decrease analgesic requirements in the post-operative period. The efficacy of dexmedetomidine in providing hemodynamic stability during perioperative period and anesthesial recovery in patients undergoing laparoscopic cholecystectomy is studied. Methods: 60 patients of ASA grade I and II and of either sex (20–50 years) allocated in one of two parallel groups containing 30 patients each. In Group A- Dexmedetomidine (i.v.) bolus over 10min and continuous maintenance infusion 0.5µg/kg/h and in group B-0.9% normal saline i.v. bolus and continuous maintenance infusion was done. Parameters noted were heart rate, mean arterial pressure, oxygen saturation, post-operative pain were evaluated using VAS and analgesic requirement. Results: Both the groups were similar results in terms of age, sex, weight, ASA status, duration of surgery and hemodynamic parameters. SBP, DBP, MAP, SpCO2, EtCO2 values for both the groups were similar at all the intervals of time. No significant side effects were noted. Conclusion: Dexmedetomidine, pre-anaesthetic medication and its intraoperative infusion, further reducing the intraoperative anaesthetic requirement, sympathoadrenal response to intubation, maintains intraoperative cardiovascular stability, smooth extubation, sedation, and reduction in postoperative complications.
{"title":"Effects of dexmedetomidine on perioperative monitoring parameters and recovery in patients undergoing laparoscopic cholecystectomy in a 300 bedded hospital, Jaipur","authors":"Mohit Kumar, Varun Kumar Saini, K. Asnani, Vivek Singhal, Rajesh Bhargava, Shaveta Kataria","doi":"10.18231/j.joapr.2022.10.3.18.27","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.3.18.27","url":null,"abstract":"Background: Laparoscopic cholecystectomy has emerged over the open cholecystectomy as gold standard for surgical treatment of symptomatic gall stones. Although pain after laparoscopic cholecystectomy is less intense, but many patients may experience considerable pain during first 24 hours in post-operative period. Intravenous (i.v.) use of dexmedetomidine in perioperative period lead to 90% decrease in the serum catecholamine levels, and further diminishing the haemodynamic response and sedating the patient and decrease analgesic requirements in the post-operative period. The efficacy of dexmedetomidine in providing hemodynamic stability during perioperative period and anesthesial recovery in patients undergoing laparoscopic cholecystectomy is studied. Methods: 60 patients of ASA grade I and II and of either sex (20–50 years) allocated in one of two parallel groups containing 30 patients each. In Group A- Dexmedetomidine (i.v.) bolus over 10min and continuous maintenance infusion 0.5µg/kg/h and in group B-0.9% normal saline i.v. bolus and continuous maintenance infusion was done. Parameters noted were heart rate, mean arterial pressure, oxygen saturation, post-operative pain were evaluated using VAS and analgesic requirement. Results: Both the groups were similar results in terms of age, sex, weight, ASA status, duration of surgery and hemodynamic parameters. SBP, DBP, MAP, SpCO2, EtCO2 values for both the groups were similar at all the intervals of time. No significant side effects were noted. Conclusion: Dexmedetomidine, pre-anaesthetic medication and its intraoperative infusion, further reducing the intraoperative anaesthetic requirement, sympathoadrenal response to intubation, maintains intraoperative cardiovascular stability, smooth extubation, sedation, and reduction in postoperative complications.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80925868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.18231/j.joapr.2022.10.3.1.4
Yogita Bundela, Dilip Agrawal, Gaurav Bhaduka
Tablet is most popular among all dosage forms today because of its convenience, ease of administration, greater flexibility in dosage form design, ease of production, and low cost and non-invasive therapy. Formulation of tablets requires API along with excipients. Excipients include lubricants, diluents, binders, glidants, disintegrants, sweetening agents, flavoring agents, etc. Recent trends indicate that multi-particulate drug delivery systems are suitable for achieving extended-release oral formulation with a low risk of dose dumping, mixing flexibility to attain difference release patterns, and reproducible and short gastric residence time. Modern technology in immediate-release tablets, such as novel granulation techniques and electrostatic dry powder coating techniques, are prevalent nowadays. Recently, the immediate-release formulation has been similar to various sustained-release formulations that are currently readily attainable.
{"title":"An overview on fundamentals of immediate release drug delivery system","authors":"Yogita Bundela, Dilip Agrawal, Gaurav Bhaduka","doi":"10.18231/j.joapr.2022.10.3.1.4","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.3.1.4","url":null,"abstract":"Tablet is most popular among all dosage forms today because of its convenience, ease of administration, greater flexibility in dosage form design, ease of production, and low cost and non-invasive therapy. Formulation of tablets requires API along with excipients. Excipients include lubricants, diluents, binders, glidants, disintegrants, sweetening agents, flavoring agents, etc. Recent trends indicate that multi-particulate drug delivery systems are suitable for achieving extended-release oral formulation with a low risk of dose dumping, mixing flexibility to attain difference release patterns, and reproducible and short gastric residence time. Modern technology in immediate-release tablets, such as novel granulation techniques and electrostatic dry powder coating techniques, are prevalent nowadays. Recently, the immediate-release formulation has been similar to various sustained-release formulations that are currently readily attainable.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80369083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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