Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.310
Kenza Cope
{"title":"Brief Report on the Treatment of Gout","authors":"Kenza Cope","doi":"10.35248/1920-4159.21.13.310","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.310","url":null,"abstract":"","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"15 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81790643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.301
S. Lakshmi
{"title":"Editorial Note On Micronutrient Deficiency in Athletes and Inefficiency of Supplementation","authors":"S. Lakshmi","doi":"10.35248/1920-4159.21.13.301","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.301","url":null,"abstract":"","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"39 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90028902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.300
E. Chavan, R. Dias, R. Magdum
Objective: Aim of the current investigation is to screen the hepatoprotective activity of the Ethanolic Extract of Allophylus Cobbe (EEAC) leaves against Paracetamol (PCM) induced hepatotoxicity in rats. Methods: EEAC was administered to the rats for 7 days (200 mg/kg and 400 mg/kg) and hepatotoxicity was induced by administration of PCM (3 g/k day . After 24 h of toxicity induction, the blood samples were collected by retro orbital plexus method and different serum and tissue biochemical parameters were analyzed. Livers of the animals were isolated and were studied for histopathological changes. The extract treated animals were compared with Silymarin (100 mg/kg). Results: Treatment of animals with EEAC at 200 and 400 mg/kg showed dose dependant significant decrease in Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Creatinine and Lipid Peroxidation (LPO) levels and significant increase in protective enzymes Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and total proteins levels in serum and tissue biochemical parameters when compared with the PCM treated rats. In histopathological study of liver, animals pretreated with EEAC showed minimal liver damage with distinct protection of structures and the architectural frame of the hepatic cells as observed by the liver section showing mild degree of liver damage, sinusoidal congestion, and mild inflammation. Allophylus Cobbe showed the presence of bioactive components having antioxidant potential; which might be responsible for hepatoprotective activity of the EEAC. Conclusion: The present study showed that EEAC restored the levels of altered biochemical parameters and prevented the liver from the toxic effects of PCM concludes that Allophylus Cobbe possess hepatoprotective activity.
{"title":"Hepatoprotective Effect of Ethanolic Extracts of Allophylus Cobbe (L.) Raeusch Leaves against Paracetamol Induced Hepatotoxicity in Rats","authors":"E. Chavan, R. Dias, R. Magdum","doi":"10.35248/1920-4159.21.13.300","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.300","url":null,"abstract":"Objective: Aim of the current investigation is to screen the hepatoprotective activity of the Ethanolic Extract of Allophylus Cobbe (EEAC) leaves against Paracetamol (PCM) induced hepatotoxicity in rats. Methods: EEAC was administered to the rats for 7 days (200 mg/kg and 400 mg/kg) and hepatotoxicity was induced by administration of PCM (3 g/k day . After 24 h of toxicity induction, the blood samples were collected by retro orbital plexus method and different serum and tissue biochemical parameters were analyzed. Livers of the animals were isolated and were studied for histopathological changes. The extract treated animals were compared with Silymarin (100 mg/kg). Results: Treatment of animals with EEAC at 200 and 400 mg/kg showed dose dependant significant decrease in Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Creatinine and Lipid Peroxidation (LPO) levels and significant increase in protective enzymes Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and total proteins levels in serum and tissue biochemical parameters when compared with the PCM treated rats. In histopathological study of liver, animals pretreated with EEAC showed minimal liver damage with distinct protection of structures and the architectural frame of the hepatic cells as observed by the liver section showing mild degree of liver damage, sinusoidal congestion, and mild inflammation. Allophylus Cobbe showed the presence of bioactive components having antioxidant potential; which might be responsible for hepatoprotective activity of the EEAC. Conclusion: The present study showed that EEAC restored the levels of altered biochemical parameters and prevented the liver from the toxic effects of PCM concludes that Allophylus Cobbe possess hepatoprotective activity.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"75 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82573619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.353
S. Hossen, M. S. Hossain
Objective: This study was undertaken to evaluate the phytochemical constituent and antioxidant activity of seven wild mushrooms of University of Chittagong campus. Methods: Phytochemical screening was performed using standard methods while DPPH radical scavenging assay was used to elucidate the antioxidant effect of eight wild mushrooms of University of Chittagong campus. Results: Results found from the quantitative analysis revealed the presence of alkaloids, glycosides, carbohydrates, steroids, tannins, flavonoids and saponins in the methanol extracts of different mushrooms. Both Ganoderma lucidum and Ganoderma applanatum showed significant (P<0.001) increase in the percentage of scavenging activity at 400 g/ml concentration when compared with ascorbic acid. An increase in the scavenging activity of DPPH radical was found with the increasing concentration of the mushrooms extracts. The methanol extract of Ganoderma lucidum, Ganoderma applanatum and Fomitopsis cajanderi showed strong antioxidant activity with an IC50 value of 35.33, 38.73 and 39.44 g/ml respectively in comparison with the IC50 value (49.19 g/ml) of ascorbic acid. Daedaleopsis confragosa (IC50: 51.21 g/ml) showed almost similar antioxidant capacity as the positive control. Conclusions: The mushroom species investigated have been shown to be great sources of antioxidants and phytochemical constituents. So, these mushrooms can be used in the management of oxidative stress induced diseases. Graphical Abstract
{"title":"Phytochemical Screening and Free Radical Scavenging Activity of Seven wild Mushrooms Growing in University of Chittagong campus","authors":"S. Hossen, M. S. Hossain","doi":"10.35248/1920-4159.21.13.353","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.353","url":null,"abstract":"Objective: This study was undertaken to evaluate the phytochemical constituent and antioxidant activity of seven wild mushrooms of University of Chittagong campus. Methods: Phytochemical screening was performed using standard methods while DPPH radical scavenging assay was used to elucidate the antioxidant effect of eight wild mushrooms of University of Chittagong campus. Results: Results found from the quantitative analysis revealed the presence of alkaloids, glycosides, carbohydrates, steroids, tannins, flavonoids and saponins in the methanol extracts of different mushrooms. Both Ganoderma lucidum and Ganoderma applanatum showed significant (P<0.001) increase in the percentage of scavenging activity at 400 g/ml concentration when compared with ascorbic acid. An increase in the scavenging activity of DPPH radical was found with the increasing concentration of the mushrooms extracts. The methanol extract of Ganoderma lucidum, Ganoderma applanatum and Fomitopsis cajanderi showed strong antioxidant activity with an IC50 value of 35.33, 38.73 and 39.44 g/ml respectively in comparison with the IC50 value (49.19 g/ml) of ascorbic acid. Daedaleopsis confragosa (IC50: 51.21 g/ml) showed almost similar antioxidant capacity as the positive control. Conclusions: The mushroom species investigated have been shown to be great sources of antioxidants and phytochemical constituents. So, these mushrooms can be used in the management of oxidative stress induced diseases. Graphical Abstract","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"37 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89708934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.298
S. Lakshmi
{"title":"Brief Report on Gene Polymorphisms in Eating Disorders","authors":"S. Lakshmi","doi":"10.35248/1920-4159.21.13.298","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.298","url":null,"abstract":"","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"85 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74553567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.299
B. Pushpa
{"title":"Editorial Note on New Target for Chemotherapy: The Footprint of Kynurenine Pathway in Every Cancer","authors":"B. Pushpa","doi":"10.35248/1920-4159.21.13.299","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.299","url":null,"abstract":"","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"26 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84788974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.297
Parag Raj Behura, T. Vamshikrishna
The novel and development of nanotechnology have brought a term targeted drug delivery system. Targeting a molecule to a specific site has brought a certain pharmacological action. Nanosponge is a part of nanotechnology which is both hydrophilic and lipophilic in nature. They are colloidal carriers which improve the aqueous solubility of the poorly soluble drug by enhancing and improving the physical and chemical stability and improving the permeability and bioavailability in the body tissues. Nanosponge are tiny sponges which are in the size of colloidal sizes and nanosized cavity. There general application can be seen in oral administration, parenteral administration, topical administration and available in the form of hydrogel. The current review discussion various methods of synthesis and application of nanosponges.
{"title":"A Novel Revolutionary Approach of a Synthesis and Application of Targeted Nanosponge Drug Delivery","authors":"Parag Raj Behura, T. Vamshikrishna","doi":"10.35248/1920-4159.21.13.297","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.297","url":null,"abstract":"The novel and development of nanotechnology have brought a term targeted drug delivery system. Targeting a molecule to a specific site has brought a certain pharmacological action. Nanosponge is a part of nanotechnology which is both hydrophilic and lipophilic in nature. They are colloidal carriers which improve the aqueous solubility of the poorly soluble drug by enhancing and improving the physical and chemical stability and improving the permeability and bioavailability in the body tissues. Nanosponge are tiny sponges which are in the size of colloidal sizes and nanosized cavity. There general application can be seen in oral administration, parenteral administration, topical administration and available in the form of hydrogel. The current review discussion various methods of synthesis and application of nanosponges.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"30 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89427034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.307
B. Sanila
{"title":"Physalis longifolia: Therapeutic Potential against Various Carcinomas","authors":"B. Sanila","doi":"10.35248/1920-4159.21.13.307","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.307","url":null,"abstract":"","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"12 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79521060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/1920-4159.21.13.311
R.e.f. Smith
{"title":"Pharmacological and Chemical Potential of Cassia fistula","authors":"R.e.f. Smith","doi":"10.35248/1920-4159.21.13.311","DOIUrl":"https://doi.org/10.35248/1920-4159.21.13.311","url":null,"abstract":"","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"100 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80985941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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